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https://www.readbyqxmd.com/read/28993678/erratum-characterization-of-mechanically-matched-hydrogel-coatings-to-improve-the-biocompatibility-of-neural-implants
#1
Kevin C Spencer, Jay C Sy, Khalil B Ramadi, Ann M Graybiel, Robert Langer, Michael J Cima
A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper.
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28690878/the-guanine-nucleotide-exchange-factor-caldag-gefi-fine-tunes-functional-properties-of-regulatory-t-cells
#2
Jana Niemz, Stefanie Kliche, Marina C Pils, Eliot Morrison, Annika Manns, Christian Freund, Jill R Crittenden, Ann M Graybiel, Melanie Galla, Lothar Jänsch, Jochen Huehn
Using quantitative phosphopeptide sequencing of unstimulated versus stimulated primary murine Foxp3(+) regulatory and Foxp3(-) conventional T cells (Tregs and Tconv, respectively), we detected a novel and differentially regulated tyrosine phosphorylation site within the C1 domain of the guanine-nucleotide exchange factor CalDAG GEFI. We hypothesized that the Treg-specific and activation-dependent reduced phosphorylation at Y523 allows binding of CalDAG GEFI to diacylglycerol, thereby impacting the formation of a Treg-specific immunological synapse...
June 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28512291/characterization-of-mechanically-matched-hydrogel-coatings-to-improve-the-biocompatibility-of-neural-implants
#3
Kevin C Spencer, Jay C Sy, Khalil B Ramadi, Ann M Graybiel, Robert Langer, Michael J Cima
Glial scar is a significant barrier to neural implant function. Micromotion between the implant and tissue is suspected to be a key driver of glial scar formation around neural implants. This study explores the ability of soft hydrogel coatings to modulate glial scar formation by reducing local strain. PEG hydrogels with controllable thickness and elastic moduli were formed on the surface of neural probes. These coatings significantly reduced the local strain resulting from micromotion around the implants. Coated implants were found to significantly reduce scarring in vivo, compared to hard implants of identical diameter...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28377698/striatal-cholinergic-interneurons-modulate-spike-timing-in-striosomes-and-matrix-by-an-amphetamine-sensitive-mechanism
#4
Jill R Crittenden, Carolyn J Lacey, Feng-Ju Weng, Catherine E Garrison, Daniel J Gibson, Yingxi Lin, Ann M Graybiel
The striatum is key for action-selection and the motivation to move. Dopamine and acetylcholine release sites are enriched in the striatum and are cross-regulated, possibly to achieve optimal behavior. Drugs of abuse, which promote abnormally high dopamine release, disrupt normal action-selection and drive restricted, repetitive behaviors (stereotypies). Stereotypies occur in a variety of disorders including obsessive-compulsive disorder, autism, schizophrenia and Huntington's disease, as well as in addictive states...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28324169/roles-of-centromedian-parafascicular-nuclei-of-thalamus-and-cholinergic-interneurons-in-the-dorsal-striatum-in-associative-learning-of-environmental-events
#5
REVIEW
Ko Yamanaka, Yukiko Hori, Takafumi Minamimoto, Hiroshi Yamada, Naoyuki Matsumoto, Kazuki Enomoto, Toshihiko Aosaki, Ann M Graybiel, Minoru Kimura
The thalamus provides a massive input to the striatum, but despite accumulating evidence, the functions of this system remain unclear. It is known, however, that the centromedian (CM) and parafascicular (Pf) nuclei of the thalamus can strongly influence particular striatal neuron subtypes, notably including the cholinergic interneurons of the striatum (CINs), key regulators of striatal function. Here, we highlight the thalamostriatal system through the CM-Pf to striatal CINs. We consider how, by virtue of the direct synaptic connections of the CM and PF, their neural activity contributes to the activity of CINs and striatal projection neurons (SPNs)...
March 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28177160/learning-new-sequential-stepping-patterns-requires-striatal-plasticity-during-the-earliest-phase-of-acquisition
#6
Toru Nakamura, Masatoshi Nagata, Takeshi Yagi, Ann M Graybiel, Tetsuo Yamamori, Takashi Kitsukawa
Animals including humans execute motor behavior to reach their goals. For this purpose, they must choose correct strategies according to environmental conditions and shape many parameters of their movements, including their serial order and timing. To investigate the neurobiology underlying such skills, we used a multi-sensor equipped, motor-driven running wheel with adjustable sequences of foothold pegs on which mice ran to obtain water reward. When the peg patterns changed from a familiar pattern to a new pattern, the mice had to learn and implement new locomotor strategies in order to receive reward...
April 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27671733/amygdala-ventral-striatum-circuit-activation-decreases-long-term-fear
#7
Susana S Correia, Anna G McGrath, Allison Lee, Ann M Graybiel, Ki A Goosens
In humans, activation of the ventral striatum, a region associated with reward processing, is associated with the extinction of fear, a goal in the treatment of fear-related disorders. This evidence suggests that extinction of aversive memories engages reward-related circuits, but a causal relationship between activity in a reward circuit and fear extinction has not been demonstrated. Here, we identify a basolateral amygdala (BLA)-ventral striatum (NAc) pathway that is activated by extinction training. Enhanced recruitment of this circuit during extinction learning, either by pairing reward with fear extinction training or by optogenetic stimulation of this circuit during fear extinction, reduces the return of fear that normally follows extinction training...
September 27, 2016: ELife
https://www.readbyqxmd.com/read/27647894/striosome-dendron-bouquets-highlight-a-unique-striatonigral-circuit-targeting-dopamine-containing-neurons
#8
Jill R Crittenden, Paul W Tillberg, Michael H Riad, Yasuyuki Shima, Charles R Gerfen, Jeffrey Curry, David E Housman, Sacha B Nelson, Edward S Boyden, Ann M Graybiel
The dopamine systems of the brain powerfully influence movement and motivation. We demonstrate that striatonigral fibers originating in striosomes form highly unusual bouquet-like arborizations that target bundles of ventrally extending dopamine-containing dendrites and clusters of their parent nigral cell bodies. Retrograde tracing showed that these clustered cell bodies in turn project to the striatum as part of the classic nigrostriatal pathway. Thus, these striosome-dendron formations, here termed "striosome-dendron bouquets," likely represent subsystems with the nigro-striato-nigral loop that are affected in human disorders including Parkinson's disease...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27595386/foxp2-controls-synaptic-wiring-of-corticostriatal-circuits-and-vocal-communication-by-opposing-mef2c
#9
Yi-Chuan Chen, Hsiao-Ying Kuo, Ulrich Bornschein, Hiroshi Takahashi, Shih-Yun Chen, Kuan-Ming Lu, Hao-Yu Yang, Gui-May Chen, Jing-Ruei Lin, Yi-Hsin Lee, Yun-Chia Chou, Sin-Jhong Cheng, Cheng-Ting Chien, Wolfgang Enard, Wulf Hevers, Svante Pääbo, Ann M Graybiel, Fu-Chin Liu
Cortico-basal ganglia circuits are critical for speech and language and are implicated in autism spectrum disorder, in which language function can be severely affected. We demonstrate that in the mouse striatum, the gene Foxp2 negatively interacts with the synapse suppressor gene Mef2c. We present causal evidence that Mef2c inhibition by Foxp2 in neonatal mouse striatum controls synaptogenesis of corticostriatal inputs and vocalization in neonates. Mef2c suppresses corticostriatal synapse formation and striatal spinogenesis, but can itself be repressed by Foxp2 through direct DNA binding...
November 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27222584/analysis-of-complex-neural-circuits-with-nonlinear-multidimensional-hidden-state-models
#10
Alexander Friedman, Joshua F Slocum, Danil Tyulmankov, Leif G Gibb, Alex Altshuler, Suthee Ruangwises, Qinru Shi, Sebastian E Toro Arana, Dirk W Beck, Jacquelyn E C Sholes, Ann M Graybiel
A universal need in understanding complex networks is the identification of individual information channels and their mutual interactions under different conditions. In neuroscience, our premier example, networks made up of billions of nodes dynamically interact to bring about thought and action. Granger causality is a powerful tool for identifying linear interactions, but handling nonlinear interactions remains an unmet challenge. We present a nonlinear multidimensional hidden state (NMHS) approach that achieves interaction strength analysis and decoding of networks with nonlinear interactions by including latent state variables for each node in the network...
June 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27069378/habit-formation
#11
REVIEW
Kyle S Smith, Ann M Graybiel
Habits, both good ones and bad ones, are pervasive in animal behavior. Important frameworks have been developed to understand habits through psychological and neurobiological studies. This work has given us a rich understanding of brain networks that promote habits, and has also helped us to understand what constitutes a habitual behavior as opposed to a behavior that is more flexible and prospective. Mounting evidence from studies using neural recording methods suggests that habit formation is not a simple process...
March 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/27026119/motion-sickness-and-resting-energy-expenditure-in-chinese-male-adults
#12
Jun-Qin Wang, Rui-Rui Qi, Lei-Lei Pan, Wei Zhou, Li-Li Zhang, Yi-Ling Cai
BACKGROUND: Motion sickness can influence energy homeostasis by enhancing thermolysis. This study tested the hypothesis that resting energy expenditure (REE), as the major component of thermogenesis, might also play a role during motion sickness. METHODS: The effect of seasickness on REE at sea was examined in 71 healthy Chinese male volunteers. Change in REE, heart rate variability (HRV), blood ghrelin levels, and leptin levels were observed across baseline, voyage, and recovery stages...
April 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/26740533/habit-formation-coincides-with-shifts-in-reinforcement-representations-in-the-sensorimotor-striatum
#13
Kyle S Smith, Ann M Graybiel
Evaluating outcomes of behavior is a central function of the striatum. In circuits engaging the dorsomedial striatum, sensitivity to goal value is accentuated during learning, whereas outcome sensitivity is thought to be minimal in the dorsolateral striatum and its habit-related corticostriatal circuits. However, a distinct population of projection neurons in the dorsolateral striatum exhibits selective sensitivity to rewards. Here, we evaluated the outcome-related signaling in such neurons as rats performed an instructional T-maze task for two rewards...
March 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/26675822/neurobiology-of-rodent-self-grooming-and-its-value-for-translational-neuroscience
#14
REVIEW
Allan V Kalueff, Adam Michael Stewart, Cai Song, Kent C Berridge, Ann M Graybiel, John C Fentress
Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders--including models of autism spectrum disorder and obsessive compulsive disorder--that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry...
January 2016: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/26460033/bursts-of-beta-oscillation-differentiate-postperformance-activity-in-the-striatum-and-motor-cortex-of-monkeys-performing-movement-tasks
#15
Joseph Feingold, Daniel J Gibson, Brian DePasquale, Ann M Graybiel
Studies of neural oscillations in the beta band (13-30 Hz) have demonstrated modulations in beta-band power associated with sensory and motor events on time scales of 1 s or more, and have shown that these are exaggerated in Parkinson's disease. However, even early reports of beta activity noted extremely fleeting episodes of beta-band oscillation lasting <150 ms. Because the interpretation of possible functions for beta-band oscillations depends strongly on the time scale over which they occur, and because of these oscillations' potential importance in Parkinson's disease and related disorders, we analyzed in detail the distributions of duration and power for beta-band activity in a large dataset recorded in the striatum and motor-premotor cortex of macaque monkeys performing reaching tasks...
November 3, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26308981/optogenetics-10-years-after-chr2-in-neurons-views-from-the-community
#16
REVIEW
Antoine Adamantidis, Silvia Arber, Jaideep S Bains, Ernst Bamberg, Antonello Bonci, György Buzsáki, Jessica A Cardin, Rui M Costa, Yang Dan, Yukiko Goda, Ann M Graybiel, Michael Häusser, Peter Hegemann, John R Huguenard, Thomas R Insel, Patricia H Janak, Daniel Johnston, Sheena A Josselyn, Christof Koch, Anatol C Kreitzer, Christian Lüscher, Robert C Malenka, Gero Miesenböck, Georg Nagel, Botond Roska, Mark J Schnitzer, Krishna V Shenoy, Ivan Soltesz, Scott M Sternson, Richard W Tsien, Roger Y Tsien, Gina G Turrigiano, Kay M Tye, Rachel I Wilson
No abstract text is available yet for this article.
September 2015: Nature Neuroscience
https://www.readbyqxmd.com/read/26291166/habit-learning-by-naive-macaques-is-marked-by-response-sharpening-of-striatal-neurons-representing-the-cost-and-outcome-of-acquired-action-sequences
#17
Theresa M Desrochers, Ken-ichi Amemori, Ann M Graybiel
Over a century of scientific work has focused on defining the factors motivating behavioral learning. Observations in animals and humans trained on a wide range of tasks support reinforcement learning (RL) algorithms as accounting for the learning. Still unknown, however, are the signals that drive learning in naive, untrained subjects. Here, we capitalized on a sequential saccade task in which macaque monkeys acquired repetitive scanning sequences without instruction. We found that spike activity in the caudate nucleus after each trial corresponded to an integrated cost-benefit signal that was highly correlated with the degree of naturalistic untutored learning by the monkeys...
August 19, 2015: Neuron
https://www.readbyqxmd.com/read/26238359/the-striatum-where-skills-and-habits-meet
#18
REVIEW
Ann M Graybiel, Scott T Grafton
After more than a century of work concentrating on the motor functions of the basal ganglia, new ideas have emerged, suggesting that the basal ganglia also have major functions in relation to learning habits and acquiring motor skills. We review the evidence supporting the role of the striatum in optimizing behavior by refining action selection and in shaping habits and skills as a modulator of motor repertoires. These findings challenge the notion that striatal learning processes are limited to the motor domain...
August 3, 2015: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/26092895/a-conversation-with-ann-graybiel
#19
Ann Graybiel, Karen Carniol
No abstract text is available yet for this article.
2014: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/26027737/a-corticostriatal-path-targeting-striosomes-controls-decision-making-under-conflict
#20
Alexander Friedman, Daigo Homma, Leif G Gibb, Ken-Ichi Amemori, Samuel J Rubin, Adam S Hood, Michael H Riad, Ann M Graybiel
A striking neurochemical form of compartmentalization has been found in the striatum of humans and other species, dividing it into striosomes and matrix. The function of this organization has been unclear, but the anatomical connections of striosomes indicate their relation to emotion-related brain regions, including the medial prefrontal cortex. We capitalized on this fact by combining pathway-specific optogenetics and electrophysiology in behaving rats to search for selective functions of striosomes. We demonstrate that a medial prefronto-striosomal circuit is selectively active in and causally necessary for cost-benefit decision-making under approach-avoidance conflict conditions known to evoke anxiety in humans...
June 4, 2015: Cell
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