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https://www.readbyqxmd.com/read/28068998/a-qualitative-study-on-african-immigrant-and-refugee-families-experiences-of-accessing-primary-health-care-services-in-manitoba-canada-it-s-not-easy
#1
Roberta Lynn Woodgate, David Shiyokha Busolo, Maryanne Crockett, Ruth Anne Dean, Miriam R Amaladas, Pierre J Plourde
BACKGROUND: Immigrant and refugee families form a growing proportion of the Canadian population and experience barriers in accessing primary health care services. The aim of this study was to examine the experiences of access to primary health care by African immigrant and refugee families. METHODS: Eighty-three families originating from 15 African countries took part in multiple open ended interviews in western Canada. Qualitative data was collected in six different languages between 2013 and 2015...
January 9, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28050745/an-evolving-ecosystem-for-natural-language-processing-in-department-of-veterans-affairs
#2
Jennifer H Garvin, Megha Kalsy, Cynthia Brandt, Stephen L Luther, Guy Divita, Gregory Coronado, Doug Redd, Carrie Christensen, Brent Hill, Natalie Kelly, Qing Zeng Treitler
In an ideal clinical Natural Language Processing (NLP) ecosystem, researchers and developers would be able to collaborate with others, undertake validation of NLP systems, components, and related resources, and disseminate them. We captured requirements and formative evaluation data from the Veterans Affairs (VA) Clinical NLP Ecosystem stakeholders using semi-structured interviews and meeting discussions. We developed a coding rubric to code interviews. We assessed inter-coder reliability using percent agreement and the kappa statistic...
February 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28048872/we-fg-bra-10-radiodosimetry-of-a-novel-alpha-particle-therapy-targeted-to-uveal-melanoma-absorbed-dose-to-organs-in-mice
#3
Christopher J Tichacek, Narges K Tafreshi, Mikalai M Budzevich, Epifanio Ruiz, Thaddeus J Wadas, Mark L McLaughlin, Eduardo G Moros, David L Morse
PURPOSE: The melanocortin-1 receptor (MC1R) is expressed in 94% of uveal melanomas and is described as an ideal target for this untreatable disease. MC1RL is a high affinity MC1R specific peptidomimetic ligand that can serve as a scaffold for therapeutic conjugates such as alpha particle emitting isotopes. The purpose of this study was to assess normal tissue distribution and risk as a result of using the DOTA chelator conjugated to MC1RL to deliver (225) Ac: MC1RL-DOTA-(225) Ac. METHODS: 17 non-tumor bearing BALB/c mice were intravenously injected with the novel MC1RL-DOTA-(225) Ac radiopharmaceutical with an average initial administered activity of 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048364/we-fg-207a-01-introduction-to-dedicated-breast-ct-early-studies
#4
S Vedantham
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047717/we-fg-207a-02-why-we-need-breast-ct-clinical-perspective
#5
A O'Connell
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047520/we-fg-207a-05-dedicated-breast-ct-as-a-diagnostic-imaging-tool-physics-and-clinical-feasibility
#6
A Karellas
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047068/we-fg-207a-03-low-dose-cone-beam-breast-ct-physics-and-technology-development
#7
J Boone
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046464/su-d-201-07-a-survey-of-radiation-oncology-residents-training-and-preparedness-to-lead-patient-safety-programs-in-clinics
#8
M Spraker, M Nyflot, E Ford, G Kane, J Zeng, K Hendrickson
PURPOSE: Safety and quality has garnered increased attention in radiation oncology, and physicians and physicists are ideal leaders of clinical patient safety programs. However, it is not clear whether residency programs incorporate formal patient safety training and adequately equip residents to assume this leadership role. A national survey was conducted to evaluate medical and physics residents' exposure to safety topics and their confidence with the skills required to lead clinical safety programs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046408/we-fg-207a-04-performance-characteristics-of-photon-counting-breast-ct
#9
W Kalender
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046291/we-fg-207a-00-advances-in-dedicated-breast-ct
#10
Srinivasan Vedantham, Sabee Molloi
: Mammography-based screening has been a valuable imaging tool for the early detection of non-palpable lesions and has contributed to significant reduction in breast cancer associated mortality. However, the breast imaging community recognizes that mammography is not ideal, and in particular is inferior for women with dense breasts. Also, the 2-D projection of a 3-D organ results in tissue superposition contributing to false-positives. The sensitivity of mammography is breast-density dependent...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032619/application-of-nanotechnology-for-the-development-of-microbicides
#11
Francis Brako, Suntharavathanan Mahalingam, Bahijja Rami-Abraham, Duncan Q M Craig, Mohan Edirisinghe
The vaginal route is increasingly being considered for both local and systemic delivery of drugs, especially those unsuitable for oral administration. One of the opportunities offered by this route but yet to be fully utilised is the administration of microbicides. Microbicides have an unprecedented potential for mitigating the global burden from HIV infection as heterosexual contact accounts for most of the new infections occurring in sub-Saharan Africa, the region with the highest prevalent rates. Decades of efforts and massive investment of resources into developing an ideal microbicide have resulted in disappointing outcomes, as attested by several clinical trials assessing the suitability of those formulated so far...
February 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28025611/evidence-and-evidence-gaps-an-introduction
#12
REVIEW
Gabriele Dreier, Jan Löhler
Background: Medical treatment requires the implementation of existing evidence in the decision making process in order to be able to find the best possible diagnostic, therapeutic or prognostic measure for the individual patient based on the physician's own expertise. Clinical trials form the evidence base and ideally, their results are assembled, analyzed, summarized, and made available in systematic review articles. Beside planning, conducting, and evaluating clinical trials in conformity with GCP (good clinical practice), it is essential that all results of conducted studies are publicly available in order to avoid publication bias...
2016: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/28008374/comparative-proteomics-analysis-of-human-osteosarcoma-by-2d-dige-with-maldi-tof-tof-ms
#13
Guoxiang Wang, Zhengyao Zhang, Maoguang Yang, Bo Xu, Qi Gao, Xiaoyu Yang
Osteosarcoma (OS) is the most common primary malignant tumor of bone and the third most common cancer in childhood and adolescence. However, controversy concerning the ideal combination of chemotherapy agents ensued throughout the last quarter of the 20th century because of conflicting and often nonrandomized data. Collaborative efforts to increase understanding of the biology of osteosarcoma and the use of preclinical models to test novel protein targets will be critical to identify the path toward improving outcomes for patients...
November 2016: Journal of Bone Oncology
https://www.readbyqxmd.com/read/27987574/-new-choosing-wisely-recommendations-of-inappropriate-interventions-the-perspective-of-general-practioners-in-switzerland
#14
Stefan Neuner-Jehle, Oliver Senn, Thomas Rosemann
AIM: As part of the "Choosing wisely" campaign expert-driven recommendations of inappropriate interventions which lead to overdiagnosis and overtreatment are being published. The aim of our work was to describe an innovative method for developing recommendations together with general practitioners (GPs) and to compare the results with the "Choosing wisely" campaign lists as well as with the Swiss "Smarter medicine" shortlist. METHODS: We asked 109 GPs who attended a medical education conference to form groups (of 5 to 7 GPs each) and develop three interventions that are relevant to their work and should be avoided...
December 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/27977385/it
#15
Jennifer May, Judi Walker, Mathew McGrail, Fran Rolley
Objectives Regional centres and their rural hinterlands support significant populations of non-metropolitan Australians. Despite their importance in the settlement hierarchy and the key medical services provided from these centres, little research has focused on their issues of workforce supply and long-term service requirements. In addition, they are a critical component of the recent growth of 'regional' hub-and-spoke specialist models of service delivery.Methods The present study interviewed 62 resident specialists in four regional centres, seeking to explore recruitment and retention factors important to their location decision making...
December 16, 2016: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/27942577/laboratory-notes-from-behavioral-pharmacologists-and-trainees-considerations-for-the-discipline
#16
Rick A Bevins, Scott T Barrett, Brady M Thompson, Steven T Pittenger
In several laboratory meetings, we discussed the challenges that face trainees in behavioral pharmacology. Major concerns, such as a difficult funding climate and limited academic job prospects were discussed at first. However, we decided to concentrate on ways to meet these challenges; versus focusing on negatives and listing gripes. Within this more constructive framework, we identified the importance of broadening training to aligned areas to enhance the capacity of behavioral pharmacologists to collaborate in multidisciplinary teams...
November 2016: Behav Anal (Wash D C)
https://www.readbyqxmd.com/read/27938644/creating-exclusive-breastfeeding-knowledge-translation-tools-with-first-nations-mothers-in-northwest-territories-canada
#17
Pertice Moffitt, Raissa Dickinson
BACKGROUND: Breastfeeding is an ideal method of infant feeding affecting lifelong health, and yet the uptake of breastfeeding in some Indigenous communities in Canada's north is low. OBJECTIVE: The aims of this project were to determine the rate and determinants of exclusive breastfeeding in a remote community in the Northwest Territories and to create knowledge translation tools to enhance breastfeeding locally. METHODS: The study methodology followed three steps...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27933528/rna-seq-in-the-collaborative-cross
#18
Richard Green, Courtney Wilkins, Martin T Ferris, Michael Gale
The Collaborative Cross (CC) is a large panel of inbred mouse strains currently being developed for multiple areas of research. Scientists are taking integrated omics-style approaches to collecting data in order to obtain a deeper understanding of the biological mechanisms underlying a number of diverse disease phenotypes. As the cost of the next generation sequencing (NGS) decreases, RNA-sequencing (RNA-seq) has become the favored approach to transcriptomic analyses versus microarrays due to increases in sensitivity and resolution...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27932369/patient-safety-in-community-dementia-services-what-can-we-learn-from-the-experiences-of-caregivers-and-healthcare-professionals
#19
Sophie Behrman, Philip Wilkinson, Helen Lloyd, Charles Vincent
OBJECTIVES: this study aims to explore how patient safety in community dementia services is understood by caregivers, and healthcare professionals. METHODS: cross-sectional analysis of guided one-to-one interviews with 10 caregivers, and 10 healthcare professionals. RESULTS: caregivers and healthcare professionals identified a range of issues including medication errors, mis-communication between professionals, unclear service pathways and the effects of stress on caregivers' behaviour...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27928508/a-perspective-on-physiological-studies-supporting-the-provision-of-scientific-advice-for-the-management-of-fraser-river-sockeye-salmon-oncorhynchus-nerka
#20
REVIEW
David A Patterson, Steven J Cooke, Scott G Hinch, Kendra A Robinson, Nathan Young, Anthony P Farrell, Kristina M Miller
The inability of physiologists to effect change in fisheries management has been the source of frustration for many decades. Close collaboration between fisheries managers and researchers has afforded our interdisciplinary team an unusual opportunity to evaluate the emerging impact that physiology can have in providing relevant and credible scientific advice to assist in management decisions. We categorize the quality of scientific advice given to management into five levels based on the type of scientific activity and resulting advice (notions, observations, descriptions, predictions and prescriptions)...
2016: Conservation Physiology
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