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https://www.readbyqxmd.com/read/28917266/urinary-biomarkers-in-prostate-cancer-detection-and-monitoring-progression
#1
REVIEW
Duojia Wu, Jie Ni, Julia Beretov, Paul Cozzi, Mark Willcox, Valerie Wasinger, Bradley Walsh, Peter Graham, Yong Li
Prostate cancer (CaP) is the most common cancer in men and the second leading cause of cancer deaths in males in Australia. Although serum prostate-specific antigen (PSA) has been the most widely used biomarker in CaP detection for decades, PSA screening has limitations such as low specificity and potential association with over-diagnosis. Current biomarkers used in the clinic are not useful for the early detection of CaP, or monitoring its progression, and have limited value in predicting response to treatment...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28904325/new-medical-education-reform-in-china-towards-healthy-china-2030
#2
Peipei Song, Chunlin Jin, Wei Tang
On July 11, 2017, the State Council of China issued a bold plan to revolutionize medical education and promote collaboration between medical education and practice. The cornerstone of the plan is training more qualified medical professionals to improve public healthcare on the path to Healthy China 2030. According to this plan, a "5+3" training system will be instituted to train medical professionals in China, and top medical colleges will be encouraged to recruit more students. However, given the less-than-ideal professional status of Chinese doctors, the frequent incidents of violence against them, long working hours and a heavy workload, and an unsatisfactory income, attracting personnel to work in medicine and health care has become a challenge...
2017: Bioscience Trends
https://www.readbyqxmd.com/read/28887068/the-rationale-design-and-methods-of-a-randomized-controlled-trial-to-evaluate-the-effectiveness-of-collaborative-telecare-in-preserving-function-among-patients-with-late-stage-cancer-and-hematologic-conditions
#3
Andrea L Cheville, Timothy Moynihan, Jeffrey R Basford, John A Nyman, Marty L Tuma, Debra A Macken, Terry Therneau, Daniel Satelel, Kurt Kroenke
Disablement affects over 40% of patients with advanced stage cancer, devastates their quality of life (QoL), and increases their healthcare costs. Proactively treating the causes of disablement; physical impairments, pain, and immobility, can prolong functional independence, improve QoL and, potentially, reduce utilization. However rehabilitation service delivery models are reactive in nature and focus on catastrophic rather than incipient disability. A validated collaborative approach, the Three Component Model (TCM), optimizes important clinical outcomes and may provide an ideal framework to overcome barriers to proactively integrating rehabilitation into cancer care...
September 5, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28865925/refining-patient-selection-for-reirradiation-of-head-and-neck-squamous-carcinoma-in-the-imrt-era-a-multi-institution-cohort-study-by-the-miri-collaborative
#4
Matthew C Ward, Nadeem Riaz, Jimmy J Caudell, Neal E Dunlap, Derek Isrow, Sara J Zakem, Joshua Dault, Musaddiq J Awan, John A Vargo, Dwight E Heron, Kristin A Higgins, Jonathan J Beitler, Samuel Marcrom, Drexell H Boggs, Comron Hassanzadeh, Chandana A Reddy, James A Bonner, Min Yao, Mitchell Machtay, Farzan Siddiqui, Andy M Trotti, Nancy Y Lee, Shlomo A Koyfman
PURPOSE: The therapeutic ratio of reirradiation for recurrent or second primary (RSP) squamous carcinoma of the head and neck may be improved in the intensity modulated radiation therapy (IMRT) era. However, patient selection for reirradiation remains challenging. We performed a multi-institution cohort study to investigate modern outcomes after IMRT-based reirradiation and to identify prognostic subgroups. PATIENTS AND METHODS: Patients with RSP squamous carcinoma originating in a previously irradiated field (≥40 Gy) who underwent reirradiation with IMRT (≥40 Gy re-IMRT) were included...
June 17, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28840935/effects-of-physical-limitations-on-daily-activities-among-adults-with-mental-health-disorders-opportunities-for-nursing-and-occupational-therapy-interventions
#5
Jennifer Gardner, Margaret Swarbrick, Ariane Ackerman, Theodora Church, Vanessa Rios, Laura Valente, John Rutledge
Individuals living with mental health disorders served by the public mental health system often face comorbid medical conditions that affect their quality of life and lifespan. The effect of physical limitations on the engagement in daily activities among individuals living with mental health disorders has not been extensively researched. Adults attending community wellness centers (N = 53) in a northeastern United State were included in a descriptive study exploring the impact of physical limitations on daily activities...
August 24, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28833351/user-participation-in-a-municipal-acute-ward-in-norway-dilemmas-in-the-interface-between-policy-ideals-and-work-conditions
#6
Anne-Kari Johannessen, Sidsel Tveiten, Anne Werner
User participation has become an increasingly important principle in health care over the last few decades. Healthcare professionals are expected to involve patients in treatment decisions. Clear guidance as to what this should entail for professionals in clinical work is not accounted for in legislation. In this study, we explore how healthcare professionals in a Municipal Acute Ward perceived, experienced and performed user participation. The ward represents a new short-time service model for emergency assistance in Norway...
August 23, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28820680/creating-online-training-for-procedures-in-global-health-with-procedural-education-for-adaptation-to-resource-limited-settings
#7
Rachel S Bensman, Tina M Slusher, Sabrina M Butteris, Michael B Pitt
The authors describe a multiinstitutional collaborative project to address a gap in global health training by creating a free online platform to share a curriculum for performing procedures in resource-limited settings. This curriculum called PEARLS (Procedural Education for Adaptation to Resource-Limited Settings) consists of peer-reviewed instructional and demonstration videos describing modifications for performing common pediatric procedures in resource-limited settings. Adaptations range from the creation of a low-cost spacer for inhaled medications to a suction chamber for continued evacuation of a chest tube...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28818442/mri-based-treatment-planning-and-dose-delivery-verification-for-intraocular-melanoma-brachytherapy
#8
Jacqueline Esthappan Zoberi, Jose Garcia-Ramirez, Samantha Hedrick, Vivian Rodriguez, Carol G Bertelsman, Stacie Mackey, Yanle Hu, H Michael Gach, P Kumar Rao, Perry W Grigsby
PURPOSE: Episcleral plaque brachytherapy (EPB) planning is conventionally based on approximations of the implant geometry with no volumetric imaging following plaque implantation. We have developed an MRI-based technique for EPB treatment planning and dose delivery verification based on the actual patient-specific geometry. METHODS AND MATERIALS: MR images of 6 patients, prescribed 85 Gy over 96 hours from Collaborative Ocular Melanoma Study-based EPB, were acquired before and after implantation...
August 14, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28810211/how-local-health-departments-work-towards-health-equity
#9
Rebeccah Sokol, Beth Moracco, Sharon Nelson, Jill Rushing, Tish Singletary, Karen Stanley, Anna Stein
BACKGROUND: Health inequities are exacerbated when health promotion programs and resources do not reach selected populations. Local health departments (LHDs)(1) have the potential to address health equity via engaging priority populations in their work. However, we do not have an understanding of what local agencies are doing on this front. METHODS: In the summer of 2016, we collaborated with informants from thirteen LHDs across North Carolina. Via semi-structured interviews, the research team asked informants about their LHD's understanding of health equity and engaging priority populations in program planning, implementation, and evaluation...
August 5, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28803651/using-national-hip-fracture-registries-and-audit-databases-to-develop-an-international-perspective
#10
Antony Johansen, David Golding, Louise Brent, Jacqueline Close, Jan-Erik Gjertsen, Graeme Holt, Ami Hommel, Alma B Pedersen, Niels Dieter Röck, Karl-Göran Thorngren
Hip fracture is the commonest reason for older people to need emergency anaesthesia and surgery, and leads to prolonged dependence for many of those who survive. People with this injury are usually identified very early in their hospital care, so hip fracture is an ideal marker condition with which to audit the care offered to older people by health services around the world. We have reviewed the reports of eight national audit programmes, to examine the approach used in each, and highlight differences in case mix, management and outcomes in different countries...
August 2, 2017: Injury
https://www.readbyqxmd.com/read/28803259/opportunities-and-challenges-in-the-immunological-therapy-of-pediatric-malignancy-a-concise-snapshot
#11
REVIEW
Francesco Ceppi, Maja Beck-Popovic, Jean-Pierre Bourquin, Raffaele Renella
Over the last 50 years, collaborative clinical trials have reduced the number of children dying from pediatric cancer significantly. Unfortunately, certain tumor types have remained resistant to conventional surgical, radiotherapy and chemotherapy combinations, and relapsing and/or refractory disease remains associated with dismal outcomes. Recently, renewed attention has been given to the role for immunotherapies in pediatric oncology. In fact, these combine several attractive features, including (but possibly not limited to) the specificity for cancer cells, potentially in vivo persistence and longevity, and potency against refractory disease...
August 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28796974/benchmarking-aided-decision-making-in-a-signal-detection-task
#12
Megan L Bartlett, Jason S McCarley
OBJECTIVE: A series of experiments examined human operators' strategies for interacting with highly (93%) reliable automated decision aids in a binary signal detection task. BACKGROUND: Operators often interact with automated decision aids in a suboptimal way, achieving performance levels lower than predicted by a statistically ideal model of information integration. To better understand operators' inefficient use of decision aids, we compared participants' automation-aided performance levels with the predictions of seven statistical models of collaborative decision making...
September 2017: Human Factors
https://www.readbyqxmd.com/read/28782458/willem-silvius-typographical-parent-of-john-dee-s-monas-hieroglyphica
#13
Manuel Mertens
The late Lode Van den Branden spend thirteen years systematically searching the archives for documents related to the Antwerp book trade of the fifteenth and sixteenth centuries, discovering new information on booksellers, printers, compositors, proof-readers, engravers, type cutters, type founders, and bookbinders. A great part of this material, now in the Royal Library of Belgium in Brussels, has yet to be studied, including his work on Willem Silvius. Guided by Van den Branden's findings, this article focuses on the period 1562-1567 in order to contextualise the collaboration between Silvius and John Dee in January 1564 which resulted in the Monas Hieroglyphica...
August 6, 2017: Ambix
https://www.readbyqxmd.com/read/28780715/innovation-in-neurosurgery-less-than-ideal-a-systematic-review
#14
REVIEW
I S Muskens, S J H Diederen, J T Senders, A H Zamanipoor Najafabadi, W R van Furth, A M May, T R Smith, A L Bredenoord, M L D Broekman
BACKGROUND: Surgical innovation is different from the introduction of novel pharmaceuticals. To help address this, in 2009 the IDEAL Collaboration (Idea, Development, Exploration, Assessment, Long-term follow-up) introduced the five-stage framework for surgical innovation. To evaluate the framework feasibility for novel neurosurgical procedure introduction, two innovative surgical procedures were examined: the endoscopic endonasal approach for skull base meningiomas (EEMS) and the WovenEndobridge (WEB device) for endovascular treatment of intracranial aneurysms...
August 6, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28770839/global-%C3%AE-hyperon-polarization-in-nuclear-collisions
#15
(no author information available yet)
The extreme energy densities generated by ultra-relativistic collisions between heavy atomic nuclei produce a state of matter that behaves surprisingly like a fluid, with exceptionally high temperature and low viscosity. Non-central collisions have angular momenta of the order of 1,000ћ, and the resulting fluid may have a strong vortical structure that must be understood to describe the fluid properly. The vortical structure is also of particular interest because the restoration of fundamental symmetries of quantum chromodynamics is expected to produce novel physical effects in the presence of strong vorticity...
August 2, 2017: Nature
https://www.readbyqxmd.com/read/28723493/proteinuria-in-patients-undergoing-renal-cancer-surgery-impact-on-overall-survival-and-stability-of-renal-function
#16
Zhiling Zhang, Juping Zhao, Joseph Zabell, Erick Remer, Jianbo Li, Jack Campbell, Wen Dong, Diego Aguilar Palacios, Tulsi Patel, Sevag Demirjian, Steven C Campbell
BACKGROUND: Proteinuria is included in the Kidney Disease: Improving Global Outcomes (KDIGO) risk stratification for chronic kidney disease (CKD) in the general population. However, the importance of proteinuria in patients with renal cancer has not been adequately studied. OBJECTIVE: To evaluate the prognostic impact of preoperative proteinuria on overall survival (OS) and renal function stability (RFS) for patients managed with renal cancer surgery. DESIGN, SETTING, AND PARTICIPANTS: From 1999 to 2008, 977 patients who underwent renal cancer surgery had preoperative data recorded for the glomerular filtration rate (GFR) estimated using the CKD Epidemiology Collaboration equation (G1 ≥90, G2 60-89, G3a 45-59, G3b 30-44, G4 15-29, and G5 <15ml/min/1...
December 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722804/balancing-life-and-work-by-unbending-gender-early-american-women-psychologists-struggles-and-contributions
#17
Elizabeth Johnston, Ann Johnson
Women's participation in the work force shifted markedly throughout the twentieth century, from a low of 21 percent in 1900 to 59 percent in 1998. The influx of women into market work, particularly married women with children, put pressure on the ideology of domesticity: an ideal male worker in the outside market married to a woman taking care of children and home (Williams, 2000). Here, we examine some moments in the early-to-mid-twentieth century when female psychologists contested established norms of life-work balance premised on domesticity...
July 2017: Journal of the History of the Behavioral Sciences
https://www.readbyqxmd.com/read/28711195/comparison-of-mdrd-ckd-epi-and-cockcroft-gault-equation-in-relation-to-measured-glomerular-filtration-rate-among-a-large-cohort-with-diabetes
#18
Anke Schwandt, Michael Denkinger, Peter Fasching, Martin Pfeifer, Christian Wagner, Jörg Weiland, Andrej Zeyfang, Reinhard W Holl
AIMS: To analyze the performance of Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockcroft-Gault (CG), and CG calculated with ideal bodyweight (CG-IBW) equations to estimate glomerular filtration rate (eGFR) based on serum creatinine in a large diabetic population. METHODS: 24,516 adults with type-1-diabetes or type-2-diabetes from the multicenter diabetes prospective follow-up registry DPV were analyzed...
September 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28686353/national-scale-precision-medicine-for-psychiatric-disorders-in-sweden
#19
REVIEW
Sarah E Bergen, Patrick F Sullivan
Since psychiatric disorders have genetic architectures dominated by common variants of small effects, successful elucidation in psychiatric genetics necessitates large sample sizes. Collaboration and unconventional ascertainment methods are required to fulfill this need. Electronic health records have been increasingly seen as holding great potential for research, although they often pose substantial technical, legal and ethical challenges. Universal health care and national-scale registers with comprehensive medical, developmental, demographic, and geographic information make the Nordic countries ideal for psychiatric genetic epidemiology...
July 7, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28685853/developing-an-interdisciplinary-and-cross-sectoral-community-of-practice-in-the-domain-of-forests-and-livelihoods
#20
Cristy Watkins, Jennifer Zavaleta, Sarah Wilson, Scott Francisco
Although significant resources are being spent researching and fostering the relationship between forests and livelihoods to promote mutually beneficial outcomes, critical gaps in our understanding persist. A core reason for such gaps is that researchers, practitioners, and policy-makers lack the structured space to interact and collaborate, which is essential for effective, interdisciplinary research, practice, and evaluation. Thus, scientific findings, policy recommendations, and measured outcomes have not always been synthesized into deep, systemic understanding; learning from practice and implementation does not easily find its way into scientific analyses--; and science often fails to influence policy...
July 7, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
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