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https://www.readbyqxmd.com/read/28063629/the-autoimmune-risk-gene-zmiz1-is-a-vitamin-d-responsive-marker-of-a-molecular-phenotype-of-multiple-sclerosis
#1
N L Fewings, P N Gatt, F C McKay, G P Parnell, S D Schibeci, J Edwards, M A Basuki, A Goldinger, M J Fabis-Pedrini, A G Kermode, C P Manrique, J L McCauley, D Nickles, S E Baranzini, T Burke, S Vucic, G J Stewart, D R Booth
Multiple Sclerosis (MS) is a neurological condition driven in part by immune cells from the peripheral circulation, the targets for current successful therapies. The autoimmune and MS risk gene ZMIZ1 is underexpressed in blood in people with MS. We show that, from three independent sets of transcriptomic data, expression of ZMIZ1 is tightly correlated with that of hundreds of other genes. Further we show expression is partially heritable (heritability 0.26), relatively stable over time, predominantly in plasmacytoid dendritic cells and non-classical monocytes, and that levels of ZMIZ1 protein expression are reduced in MS...
January 4, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28012189/vitamin-d3-derivatives-alone-or-in-combination-with-glucocorticoids-suppress-streptococcal-pyrogenic-enterotoxin-a-stimulated-proliferation-of-peripheral-blood-mononuclear-cells-in-patients-with-psoriasis
#2
Kae Usui, Yukari Okubo, Toshihiko Hirano, Ryoji Tsuboi
Bacterial colonization on skin or tonsil may influence the clinical response of patients with psoriasis to immunosuppressive drugs. However, few studies have investigated the effects of bacterial superantigens on therapy in these patients. Recently, combination therapy with topical glucocorticoids (GC) and vitamin D3 (VD3) appears to be more effective than GC or VD3 monotherapy for psoriasis. We evaluated the suppressive effects of betamethasone butyrate propionate (BBP), three VD3 derivatives (calcipotriol, maxacalcitol and tacalcitol), cyclosporin and BBP plus VD3, on concanavalin A (ConA)- or streptococcal pyrogenic enterotoxin A (SPEA)-stimulated proliferation of peripheral blood mononuclear cells (PBMC) obtained from 35 psoriasis patients...
December 24, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27995521/efficacy-and-safety-of-calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-compared-with-betamethasone-17-valerate-medicated-plaster-for-the-treatment-of-psoriasis
#3
Catherine Queille-Roussel, Monika Rosen, Fabrice Clonier, Kasper Nørremark, Jean-Philippe Lacour
BACKGROUND: Fixed combination calcipotriol as hydrate (Cal) 50 µg/g plus betamethasone as dipropionate (BD) 0.5 mg/g aerosol foam is an alcohol-free treatment for psoriasis. Betamethasone 17-valerate 2.25 mg (BV)-medicated plasters are recommended for treating psoriasis plaques localized in difficult-to-treat (DTT; elbow, knee, anterior face of the tibia) areas. OBJECTIVE: The aim of this study was to compare the efficacy of Cal/BD foam with BV-medicated plaster in patients with plaque psoriasis...
December 19, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27971587/efficacy-of-the-fixed-combination-of-calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-vs-traditional-topical-treatment-in-psoriasis-a-bayesian-network-meta-analysis
#4
H Young, G Moncrieff, G Greenall, A H Møller
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970515/the-cost-effectiveness-of-blue-light-therapy-vs-fixed-combination-of-calcipotriol-and-betamethasone-dipropionate-gel-in-the-treatment-of-mild-to-moderate-psoriasis
#5
A Ansaripour, H B Thio, R Maessen, W K Redekop
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27964877/corrigendum-to-calcipotriol-and-betamethasone-dipropionate-exert-additive-inhibitory-effects-on-the-cytokine-expression-of-inflammatory-dendritic-cell-th17-cell-axis-in-psoriasis-j-dermatol-sci-81-2016-153-164
#6
Paola Lovato, Hanne Norsgaard, Yoshiki Tokura, Mads A Røpke
No abstract text is available yet for this article.
February 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27936972/fixed-combination-calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-in-the-treatment-of-psoriasis-vulgaris-rationale-for-development-and-clinical-profile
#7
Carle Paul, Bo Bang, Mark Lebwohl
Psoriasis is a chronic, immune-mediated inflammatory disorder with a significant negative impact on quality of life. Most patients with mild-to-moderate psoriasis manage their disease with topical therapies; the most commonly used formulations contain corticosteroids and/or vitamin D3 analogues. However, adherence to topical treatment remains a significant issue as the daily treatment regimen can be cumbersome and time consuming and many patients do not obtain complete/almost complete clearance. Areas covered: Published pre-clinical and clinical data evaluating calcipotriol 50 µg/g (Cal) and betamethasone 0...
January 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27882780/solid-lipid-nanoparticles-and-nanostructured-lipid-carrier-based-nanotherapeutics-in-treatment-of-psoriasis-a-comparative-study
#8
Rhythm Arora, Sameer S Katiyar, Varun Kushwah, Sanyog Jain
BACKGROUND: The present work focuses on the development of ultra-small solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) encapsulating cyclosporine and calcipotriol, further incorporated into gel, increasing their penetration through the skin. RESEARCH DESIGN AND METHODS: Developed SLN and NLC were characterized regarding particle size, zeta potential, %entrapment efficiency and dispersed into carbopol 934P-NF gel. Gel was further characterized for rheological behavior and spreadability...
December 4, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27878842/pharmacologic-treatment-of-vitiligo-in-children-and-adolescents-a-systematic-review
#9
REVIEW
Andreia Freire de Menezes, Fernanda Oliveira de Carvalho, Rosana S S Barreto, Bruno de Santana Silva, Saravanan Shanmugam, Ricardo Queiroz Gurgel, Adriano Antunes de Souza Araújo
BACKGROUND: The true pathogenic mechanism of vitiligo is still unknown. About half of the patients with this disease have onset before the age of 20 years, making it a serious dermatologic disorder in childhood. OBJECTIVES: The objective of this study was to review the literature in a systematic way and identify the main pharmacologic treatments and outcomes in children and adolescents with vitiligo. METHODS: Four databases-the National Library of Medicine (MEDLINE-PubMed), Web of Science, Scopus, and Latin American and Caribbean Health Sciences (LILACS)-were used for the search up to January 2015...
January 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/27869649/randomized-trial-of-calcipotriol-combined-with-5-fluorouracil-for-skin-cancer-precursor-immunotherapy
#10
Trevor J Cunningham, Mary Tabacchi, Jean-Pierre Eliane, Sara Moradi Tuchayi, Sindhu Manivasagam, Hengameh Mirzaalian, Ahu Turkoz, Raphael Kopan, Andras Schaffer, Arturo P Saavedra, Michael Wallendorf, Lynn A Cornelius, Shadmehr Demehri
BACKGROUND: Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments. Thymic stromal lymphopoietin (TSLP) is an epithelium-derived cytokine that induces a robust antitumor immunity in barrier-defective skin. Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27868150/clinical-efficiency-of-topical-calcipotriol-betamethasone-treatment-in-psoriasis-relies-on-suppression-of-the-inflammatory-tnf%C3%AE-il-23-il-17-axis
#11
Minna E Kubin, Nina Kokkonen, Riitta Palatsi, Päivi M Hägg, Juha P Väyrynen, Virpi Glumoff, Kirsi-Maria Haapasaari, Tiina Hurskainen, Kaisa Tasanen
The effects of topical calcipotriol/betamethasone combination therapy and betamethasone monotherapy on inflammatory T cell numbers and molecular markers were compared in patients with psoriasis. Combination therapy down-regulated the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-23A, IL-17A, S100A7, CCL-20 and interferon (IFN)-γ in skin and TNF-α, IL-6, IL-23A, T-bet and IFN-γ in peripheral blood mononuclear cells (PBMCs). Betamethasone monotherapy had less effect. Expression of FoxP3 in both skin and PBMCs was down-regulated by calcipotriol/betamethasone, but not by betamethasone...
November 21, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27789051/-multiple-epidermolytic-acanthomas-of-the-genitalia
#12
I Moulonguet, M Serre, D Herskovitch
BACKGROUND: Epidermolytic hyperkeratosis presents a particular histological image common to several clinical pictures, including that of keratinopathic ichthyoses. It may also occur fortuitously in various tumoral and inflammatory lesions. It is the elementary histopathological lesion of epidermolytic acanthoma, which may either be single or multiple, and when it occurs in the genital area, is known as epidermolytic hyperkeratosis of the genitalia or multiple epidermolytic acanthoma of the genitalia...
October 24, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27786594/worldwide-utilization-of-topical-remedies-in-treatment-of-psoriasis-a-systematic-review
#13
Mathias Tiedemann Svendsen, Janithika Jeyabalan, Klaus Ejner Andersen, Flemming Andersen, Helle Johannessen
OBJECTIVE: To review published literature describing the global use of topical antipsoriatics. MATERIALS AND METHODS: Search for English-language articles in Embase, Pubmed, PsycINFO and Cochrane Library. RESULTS: Fifty-four selected publications were found, describing psoriasis patients' use of topical antipsoriatics, using six different methods to collect data. The eight most frequently used topical treatments from the regions North/South America, North/Central/South Europe, Asia, Middle East and Australia were: corticosteroids used by 16-79%, complementary and alternative medicines used by 10-62%, phototherapies used by 0...
November 13, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27761089/evaluation-of-carbon-dioxide-laser-in-the-treatment-of-epidermal-nevi
#14
Yasmeen Jabeen Bhat, Iffat Hassan, Peerzada Sajad, Atiya Yaseen, Syed Mubashir, Saniya Akhter, Roohi Wani
BACKGROUND: Epidermal naevi are benign hamartomatous growths of the skin which are generally asymptomatic with a benign course but are cosmetically disagreeable. Topical treatments such as steroids, calcipotriol, 5 fluorouracil, podophyllin, retinoids and cryotherapy are ineffective and surgical excision results in scar formation. Therapy is often challenging. AIM OF THE STUDY: To study the response of carbon dioxide (CO2) laser in the management of epidermal naevi...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27723134/optimal-maintenance-treatment-with-calcipotriol-betamethasone-dipropionate-gel-in-korean-patients-with-psoriasis-vulgaris-a-multicentre-randomized-controlled-clinical-trial
#15
J-H Lee, C-J Park, T-Y Kim, Y-B Choe, N-I Kim, H-J Song, J-I Youn, S-W Youn, J-H Choi, K-J Kim
BACKGROUND: There is a lack of response data for topical treatments for psoriasis vulgaris in Asian patients. OBJECTIVES: To determine the optimal maintenance regimen for topical treatment with calcipotriol monohydrate/betamethasone dipropionate gel in Korean patients with psoriasis vulgaris, by comparing the efficacy of three 8-week maintenance regimens. METHODS: This was a multicentre, prospective, randomized, controlled, parallel-group, open-label, phase 4 clinical trial, conducted in South Korea...
October 10, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27716422/a-statistical-analysis-plan-for-the-efficiency-and-safety-of-chinese-herbal-medicine-used-concurrently-with-topical-therapy-for-psoriasis-vulgaris
#16
Liming Lu, Meiling Xuan, Yuhong Yan, Geng Li, Li Zhou, Zehuai Wen, Chuanjian Lu
BACKGROUND: Psoriasis vulgaris (PV) has been causing increasing concern due to its highly prevalent, harmful and therapy-resistant characteristics. The YXBCM01 (Chinese herbal medicine) for PV trial evaluates the effects of YXBCM01 on relapse rate in patients suffering from PV. As an update to the published design and method for the trial, this paper presents the statistical plan for the main publication to avoid the risk of outcome reporting bias, selective reporting, and data-driven results...
October 3, 2016: Trials
https://www.readbyqxmd.com/read/27714595/calcipotriol-plus-betamethasone-dipropionate-aerosol-foam-is-effective-independent-of-body-mass-index-and-the-extent-and-severity-of-psoriasis
#17
Linda Stein Gold, John Villumsen, Monika Rosen
INTRODUCTION: Good treatment adherence is important in the effective management of psoriasis and is related to both the frequency of applications and the amount of product used versus the recommended dose. The efficacy and safety of fixed combination calcipotriol 50 µg/g (Cal) and betamethasone 0.5 mg/g as dipropionate (BD) in the treatment of psoriasis is well established; an aerosol foam formulation has been developed to enhance adherence. This subanalysis from the Phase III PSO-FAST study evaluates the amount of Cal/BD foam used during treatment and the association between the extent and severity of baseline disease...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27663245/calcipotriol-betamethasone-dipropionate-foam-a-review-in-plaque-psoriasis
#18
Esther S Kim, James E Frampton
Calcipotriol/betamethasone dipropionate foam (Enstilar(®)) is a once-daily synthetic vitamin D3 analogue and synthetic corticosteroid fixed-dose combination foam formulation that is indicated for the topical treatment of plaque psoriasis in adults. In randomized, multicentre trials, treatment with calcipotriol/betamethasone dipropionate foam for 4 weeks resulted in greater proportions of patients achieving treatment success [of the body (i.e. trunk and/or limbs), as assessed by a physician] compared with 4 weeks' treatment with the foam vehicle, individual components as foam, or calcipotriol/betamethasone dipropionate fixed-dose combination as an ointment, or 8 weeks' treatment with the fixed-dose combination as a topical suspension...
October 2016: Drugs
https://www.readbyqxmd.com/read/27663156/isolated-linear-blaschkoid-psoriasis
#19
M Nasimi, R Abedini, A Azizpour, A Nikoo
Linear psoriasis (LPs) is considered a rare clinical presentation of psoriasis, which is characterized by linear erythematous and scaly lesions along the lines of Blaschko. We report the case of a 20-year-old man who presented with asymptomatic linear and S-shaped erythematous, scaly plaques on right side of his trunk. The plaques were arranged along the lines of Blaschko with a sharp demarcation at the midline. Histological examination of a skin biopsy confirmed the diagnosis of psoriasis. Topical calcipotriol and betamethasone dipropionate ointments were prescribed for 2 months...
October 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27650520/managing-scalp-psoriasis-an-evidence-based-review
#20
Ting-Shun Wang, Tsen-Fang Tsai
BACKGROUND: Scalp psoriasis is commonly the initial presentation of psoriasis, and almost 80 % of patients with psoriasis will eventually experience it. OBJECTIVE: Although several systematic reviews and guidelines exist, an up-to-date evidence-based review including more recent progress on the use of biologics and new oral small molecules was timely. METHODS: Of the 475 studies initially retrieved from PubMed and the 845 from Embase (up to May 2016), this review includes 27 clinical trials, four papers reporting pooled analyses of other clinical trials, ten open-label trials, one case series, and two case reports after excluding non-English literature...
September 21, 2016: American Journal of Clinical Dermatology
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