Aolin Yang, Yanmei Chen, Yizhen Gao, Qingqing Lv, Yao Li, Fengna Li, Ruirui Yu, Ziyu Han, Shimiao Dai, Junying Zhu, Chenggang Yang, Shi Zhan, Litao Sun, Ji-Chang Zhou
The role of vitamin D (VD) in non-alcoholic fatty liver disease (NAFLD) remains controversial, possibly due to the differential effects of various forms of VD. In our study, Sod1 gene knockout (SKO) mice were utilized as lean NAFLD models, which were administered 15 000 IU VD3 per kg diet, or intraperitoneally injected with the active VD analog calcipotriol for 12 weeks. We found that VD3 exacerbated hepatic steatosis in SKO mice, with an increase in the levels of Cd36 , Fatp2 , Dgat2 , and CEBPA. However, calcipotriol exerted no significant effect on hepatic steatosis...
April 9, 2024: Food & Function