keyword
https://read.qxmd.com/read/38537199/fopgdb-a-pangenome-database-of-fusarium-oxysporum-a-cross-kingdom-fungal-pathogen
#1
JOURNAL ARTICLE
Tan Meng, Hanqing Jiao, Yi Zhang, Yi Zhou, Shaoying Chen, Xinrui Wang, Bowen Yang, Jie Sun, Xin Geng, Dilay Hazal Ayhan, Li Guo
Pangenomes, capturing the genetic diversity of a species or genus, are essential to understanding the ecology, pathobiology and evolutionary mechanisms of fungi that cause infection in crops and humans. However, fungal pangenome databases remain unavailable. Here, we report the first fungal pangenome database, specifically for Fusarium oxysporum species complex (FOSC), a group of cross-kingdom pathogens causing devastating vascular wilt to over 100 plant species and life-threatening fusariosis to immunocompromised humans...
March 27, 2024: Database: the Journal of Biological Databases and Curation
https://read.qxmd.com/read/38536913/cardiac-tissue-model-of-immune-induced-dysfunction-reveals-the-role-of-free-mitochondrial-dna-and-the-therapeutic-effects-of-exosomes
#2
JOURNAL ARTICLE
Rick Xing Ze Lu, Naimeh Rafatian, Yimu Zhao, Karl T Wagner, Erika L Beroncal, Bo Li, Carol Lee, Jingan Chen, Eryn Churcher, Daniel Vosoughi, Chuan Liu, Ying Wang, Andrew Baker, Uriel Trahtemberg, Bowen Li, Agostino Pierro, Ana C Andreazza, Claudia C Dos Santos, Milica Radisic
Despite tremendous progress in the development of mature heart-on-a-chip models, human cell-based models of myocardial inflammation are lacking. Here, we bioengineered a vascularized heart-on-a-chip with circulating immune cells to model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced acute myocarditis. We observed hallmarks of coronavirus disease (COVID-19)-induced myocardial inflammation, as the presence of immune cells augmented the secretion of proinflammatory cytokines, triggered progressive impairment of contractile function, and altered intracellular calcium transients...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38531483/fxr-menin-mediated-epigenetic-regulation-of-e2f3-expression-controls-%C3%AE-cell-proliferation-and-is-increased-in-islets-from-diabetic-gk-rats-after-rygb
#3
JOURNAL ARTICLE
Xiangchen Kong, Chenxi Yang, Bingfeng Li, Dan Yan, Yanhui Yang, Cuihua Cao, Bowen Xing, Xiaosong Ma
Farnesoid X receptor (FXR) improves the function of islets, especially in the setting of Roux-en-Y gastric bypass (RYGB). Here we investigated how FXR activation regulates β-cell proliferation and explored the potential link between FXR signaling and the menin pathway in controlling E2F3 expression, a key transcription factor for controlling adult β-cell proliferation. Stimulation with the FXR agonist GW4064 or chenodeoxycholic acid (CDCA) increased E2F3 expression and β-cell proliferation...
March 24, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38528499/m6a-tcpred-a-web-server-to-predict-tissue-conserved-human-m-6-a-sites-using-machine-learning-approach
#4
JOURNAL ARTICLE
Gang Tu, Xuan Wang, Rong Xia, Bowen Song
BACKGROUND: N6-methyladenosine (m6 A) is the most prevalent post-transcriptional modification in eukaryotic cells that plays a crucial role in regulating various biological processes, and dysregulation of m6 A status is involved in multiple human diseases including cancer contexts. A number of prediction frameworks have been proposed for high-accuracy identification of putative m6 A sites, however, none have targeted for direct prediction of tissue-conserved m6 A modified residues from non-conserved ones at base-resolution level...
March 25, 2024: BMC Bioinformatics
https://read.qxmd.com/read/38527980/immunoexpression-of-ki67-p16-and-beta-catenin-in-precursor-lesions-of-cutaneous-squamous-cell-carcinoma
#5
JOURNAL ARTICLE
Alina Maria Vîlcea, Loredana Elena Stoica, Bianca Cătălina Andreiana, Cecil Sorin Mirea, Tiberiu Ştefăniţă Ţenea Cojan, Ioana Cristina Vîlcea, Claudiu Mărgăritescu
Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer, after basal cell carcinoma, representing about 10-20% of all malignant skin tumors. The mortality rates of CSCC approach those of renal and oropharyngeal carcinomas, as well as melanoma, with the increasing of the risk once metastases and perineural invasion occur. Both actinic keratosis (AK) and Bowen's disease (BD) are direct precursors with the potential for progression to CSCC. In this study, we analyzed the expression of Ki67, P16 and Beta-catenin in the precursor lesions of CSCC in relation to histological prognostic parameters, respectively between them, with the aim of identifying possible correlations with a role in prognosis...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38525448/a-highly-sensitive-and-long-term-stable-wearable-patch-for-continuous-analysis-of-biomarkers-in-sweat
#6
JOURNAL ARTICLE
Farnaz Lorestani, Xianzhe Zhang, Abu Musa Abdullah, Xin Xin, Yushen Liu, Mashfiqur Rahman, Md Abu Sayeed Biswas, Bowen Li, Ankan Dutta, Zhenyuan Niu, Shuvendu Das, Shishir Barai, Ke Wang, Huanyu Cheng
Although increasing efforts have been devoted to the development of non-invasive wearable or stretchable electrochemical sweat sensors for monitoring physiological and metabolic information, most of them still suffer from poor stability and specificity over time and fluctuating temperatures. This study reports the design and fabrication of a long-term stable and highly sensitive flexible electrochemical sensor based on nanocomposite-modified porous graphene by simple and facile laser treatment for detecting biomarkers such as glucose in sweat...
December 22, 2023: Advanced Functional Materials
https://read.qxmd.com/read/38524134/autoimmune-and-neuropsychiatric-phenotypes-in-a-mecp2-transgenic-mouse-model-on-c57bl-6-background
#7
JOURNAL ARTICLE
Yaxi Li, Shu Zhang, Chenling Tang, Bowen Yang, Fatin Atrooz, Zhifeng Ren, Chandra Mohan, Samina Salim, Tianfu Wu
INTRODUCTION: Systemic Lupus Erythematosus (SLE) impacts the central nervous system (CNS), leading to severe neurological and psychiatric manifestations known as neuropsychiatric lupus (NPSLE). The complexity and heterogeneity of clinical presentations of NPSLE impede direct investigation of disease etiology in patients. The limitations of existing mouse models developed for NPSLE obstruct a comprehensive understanding of this disease. Hence, the identification of a robust mouse model of NPSLE is desirable...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38513648/cytosolic-ph-is-a-direct-nexus-in-linking-environmental-cues-with-insulin-processing-and-secretion-in-pancreatic-%C3%AE-cells
#8
JOURNAL ARTICLE
Yujiang Fang, Hexi Feng, Bowen Zhang, Shuwei Zhang, Yanjie Zhou, Pengcheng Hao, Zhongshu Zhou, Shanshan Zhou, Nan Li, Yi Hui, Lin Ma, Jie Xiong, Jinjin Wu, Ling Liu, Xiaoqing Zhang
Pancreatic β cells actively respond to glucose fluctuations through regulating insulin processing and secretion. However, how this process is elaborately tuned in circumstance of variable microenvironments as well as β cell-intrinsic states and whether its dysfunction links to metabolic diseases remain largely elusive. Here, we show that the cytosolic pH (pHc) in β cells is increased upon glucose challenge, which can be sensed by Smad5 via its nucleocytoplasmic shuttling. Lesion of Smad5 in β cells results in hyperglycemia and glucose intolerance due to insulin processing and secretion deficiency...
March 15, 2024: Cell Metabolism
https://read.qxmd.com/read/38512035/-yes-associated-protein-yap-promotes-invasion-and-migration-of-cutaneous-squamous-cell-carcinoma-cells-by-activating-the-pi3k-akt-pathway
#9
JOURNAL ARTICLE
Zhenling Li, Fan Yang, Xuemei Jin, Xueyan Wang, Taiqin Chen, Chunji Quan
Objective To investigate the expression of Yes-associated protein (YAP) in cutaneous squamous cell carcinoma (cSCC) and its effects on invasion and migration. Methods Immunohistochemical staining was used to detect the expression of YAP in cSCC, Bowen disease (BD), and adjacent normal tissues, and analyzed the correlation between YAP expression and clinicopathological characteristics of cSCC. A stable cell line in A431 cells with YAP gene silencing was established through lentiviral infection. Tetramethylrhodamine isothiocyanate (TRITC)-phalloidin staining was performed to analyze the distribution and number of microfilaments in A431 cells...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38511933/lvs-%C3%AE-capb-vectored-multiantigenic-melioidosis-vaccines-protect-against-lethal-respiratory-burkholderia-pseudomallei-challenge-in-highly-sensitive-balb-c-mice
#10
JOURNAL ARTICLE
Michael V Tullius, Richard A Bowen, Peter S Back, Saša Masleša-Galić, Susana Nava, Marcus A Horwitz
UNLABELLED: Melioidosis, caused by the intracellular bacterial pathogen and Tier 1 select agent Burkholderia pseudomallei (Bp), is a highly fatal disease endemic in tropical areas. No licensed vaccine against melioidosis exists. In preclinical vaccine studies, demonstrating protection against respiratory infection in the highly sensitive BALB/c mouse has been especially challenging. To address this challenge, we have used a safe yet potent live attenuated platform vector, LVS Δ capB , previously used successfully to develop vaccines against the Tier 1 select agents of tularemia, anthrax, and plague, to develop a melioidosis vaccine...
March 21, 2024: MBio
https://read.qxmd.com/read/38510990/fournier-s-gangrene-a-review-of-predictive-scoring-systems-and-practical-guide-for-patient-management
#11
REVIEW
Daniel Bowen, Thomas Hughes, Patrick Juliebø-Jones, Bhaskar Somani
This article aims to provide a practical guide for patient management and an overview of the predictive scorings for Fournier's gangrene (FG) that are available to aid clinicians. A literature was performed reviewing currently used scoring systems for FG and presenting a practical guide for its management based on the available evidence. There are four specific scoring systems available for the assessment of FG although few other non-specific and generic tools also exist. These specific tools include Laboratory Risk Indicator for Necrotizing Fasciitis, Fournier's Gangrene Severity Index, Uludag Fournier's Gangrene Severity Index, and Simplified Fournier's Gangrene Severity Index and help calculate expected mortality...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38510149/epigenetic-transcriptional-and-functional-characterization-of-myeloid-cells-in-familial-mediterranean-fever
#12
JOURNAL ARTICLE
Rutger J Röring, Wenchao Li, Ruiqi Liu, Mariolina Bruno, Bowen Zhang, Priya A Debisarun, Orsolya Gaal, Medeea Badii, Viola Klück, Simone J C F M Moorlag, Frank van de Veerdonk, Yang Li, Leo A B Joosten, Mihai G Netea
Familial Mediterranean fever (FMF) is a periodic fever syndrome caused by variation in MEFV . FMF is known for IL-1β dysregulation, but the innate immune landscape of this disease has not been comprehensively described. Therefore, we studied circulating inflammatory proteins, and the function of monocytes and (albeit less extensively) neutrophils in treated FMF patients in remission. We found that monocyte IL-1β and IL-6 production was enhanced upon stimulation, in concordance with alterations in the plasma inflammatory proteome...
April 19, 2024: IScience
https://read.qxmd.com/read/38509584/pdgfr%C3%AE-%C3%A2-%C3%A2-cell-hif2%C3%AE-is-dispensable-for-white-adipose-tissue-metabolic-remodeling-and-hepatic-lipid-accumulation-in-obese-mice
#13
JOURNAL ARTICLE
Tao Yao, Danni Wei, Xin Tian, Lin Zhao, Qiangyou Wan, Xiaoli Zhang, Juan Cai, Siqi Li, Bowen Diao, Suihan Feng, Bo Shan, Mengle Shao, Ying Wu
BACKGROUND: Obesity is associated with extensive white adipose tissue (WAT) expansion and remodeling. Healthy WAT expansion contributes to the maintenance of energy balance in the liver, thereby ameliorating obesity-related hepatic steatosis. Tissue-resident mesenchymal stromal cell populations, including PDGFRβ + perivascular cells, are increasingly recognized pivotal as determinants of the manner in which WAT expands. However, the full array of regulatory factors controlling WAT stromal cell functions remains to be fully elucidated...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38505683/activity-counseling-early-postelective-percutaneous-coronary-intervention-ace-pci-mixed-methods-pilot-randomized-controlled-trial
#14
JOURNAL ARTICLE
Nicole Freene, Suzanne J Carroll, Allyson Flynn, Sarah Bowen, Roslyn Holley, Kerry Rodway, Theo Niyonsenga, Rachel Davey
BACKGROUND: Physical activity (PA) levels of people with coronary heart disease are low in the first 30 days after percutaneous coronary intervention (PCI), increasing the risk of recurrent cardiac events. Following PCI, PA counseling delivered by a physiotherapist before discharge may increase the PA levels of patients. Preliminary work is required to determine the effects of the counseling session compared to usual care. OBJECTIVES: To investigate the feasibility and potential efficacy of a brief physiotherapist-led PA counseling session immediately after an elective PCI compared to usual care for improved PA early post-PCI...
March 2024: Health Science Reports
https://read.qxmd.com/read/38504565/identification-of-pdgfa-as-a-neutrophil-related-biomarker-linked-to-the-advancement-of-diabetic-retinopathy-through-integrated-bioinformatics-analysis
#15
JOURNAL ARTICLE
Anran Liang, Tingting Feng, Xiang Gao, Bowen Zhao, Song Chen
BACKGROUND: The dysregulation of the innate immune system plays a crucial role in the development of Diabetic Retinopathy (DR). To gain an insight into the underlying mechanism of DR, it is essential to identify specific biomarkers associated with immune cell infiltration. METHODS: In this study, we retrieved the GSE94019 and GSE60436 datasets from the Gene Expression Omnibus (GEO) database. By utilizing CIBERSORT, MCPcounter, and xCell algorithms, we conducted a comprehensive analysis of the immune cell infiltration landscape in DR...
March 19, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/38504018/towards-a-general-purpose-foundation-model-for-computational-pathology
#16
JOURNAL ARTICLE
Richard J Chen, Tong Ding, Ming Y Lu, Drew F K Williamson, Guillaume Jaume, Andrew H Song, Bowen Chen, Andrew Zhang, Daniel Shao, Muhammad Shaban, Mane Williams, Lukas Oldenburg, Luca L Weishaupt, Judy J Wang, Anurag Vaidya, Long Phi Le, Georg Gerber, Sharifa Sahai, Walt Williams, Faisal Mahmood
Quantitative evaluation of tissue images is crucial for computational pathology (CPath) tasks, requiring the objective characterization of histopathological entities from whole-slide images (WSIs). The high resolution of WSIs and the variability of morphological features present significant challenges, complicating the large-scale annotation of data for high-performance applications. To address this challenge, current efforts have proposed the use of pretrained image encoders through transfer learning from natural image datasets or self-supervised learning on publicly available histopathology datasets, but have not been extensively developed and evaluated across diverse tissue types at scale...
March 19, 2024: Nature Medicine
https://read.qxmd.com/read/38504017/a-visual-language-foundation-model-for-computational-pathology
#17
JOURNAL ARTICLE
Ming Y Lu, Bowen Chen, Drew F K Williamson, Richard J Chen, Ivy Liang, Tong Ding, Guillaume Jaume, Igor Odintsov, Long Phi Le, Georg Gerber, Anil V Parwani, Andrew Zhang, Faisal Mahmood
The accelerated adoption of digital pathology and advances in deep learning have enabled the development of robust models for various pathology tasks across a diverse array of diseases and patient cohorts. However, model training is often difficult due to label scarcity in the medical domain, and a model's usage is limited by the specific task and disease for which it is trained. Additionally, most models in histopathology leverage only image data, a stark contrast to how humans teach each other and reason about histopathologic entities...
March 19, 2024: Nature Medicine
https://read.qxmd.com/read/38497297/effect-of-glabridin-combined-with-bakuchiol-on-uvb-induced-skin-damage-and-its-underlying-mechanism-an-experimental-study
#18
JOURNAL ARTICLE
Guanjie Peng, Yangsi Li, Yiyan Zeng, Bowen Sun, Lanyue Zhang, Qingqing Liu
BACKGROUND: Research has demonstrated the anti-photoaging properties of glabridin and bakuchiol. METHODS: The impact of glabridin, glabridin + bakuchiol, and bakuchiol on the levels of tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) in mice skin fibroblasts was observed. Furthermore, we investigated the potential roles of fibronectin (FN), interferon-γ (IFN-γ), interleukin-22 (IL-22), and transforming growth factor-β (TGF-β) in the tissues, and evaluated their impact on the enzymatic levels in the skin...
March 18, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38493885/contribution-of-platelets-to-disruption-of-the-blood-brain-barrier-during-arterial-baroreflex-dysfunction
#19
JOURNAL ARTICLE
Bowen Shen, Lili Yang, Xiaoli Jia, Deping Kong, Yongfeng Gao, Shan Gao, Ruimin Chen, Fengbao Chen, Chunyu Zhao, Yue Li, Rui Tan, Xiaomin Zhao
BACKGROUND: Arterial baroreflex dysfunction, like many other central nervous system disorders, involves disruption of the blood-brain barrier, but what causes such disruption in ABR dysfunction is unclear. Here we explored the potential role of platelets in this disruption. METHODS: ABR dysfunction was induced in rats using sinoaortic denervation, and the effects on integrity of the blood-brain barrier were explored based on leakage of Evans blue or FITC-dextran, while the effects on expression of CD40L in platelets and of key proteins in microvascular endothelial cells were explored using immunohistochemistry, western blotting and enzyme-linked immunosorbent assay...
March 15, 2024: Microvascular Research
https://read.qxmd.com/read/38492247/molecular-characterization-of-a-virulent-goose-astrovirus-genotype-2-with-high-mortality-in-vitro-and-in-vivo
#20
JOURNAL ARTICLE
Linhua Xu, Zhen Wu, Yu He, Bowen Jiang, Yao Cheng, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Anchun Cheng, Shun Chen
Goose astrovirus (GAstV) is a newly identified viral pathogen threatening waterfowl, exhibiting a high prevalence across various regions in China. Notably, the Guanghan District of Deyang City, situated in Sichuan Province, has faced a outbreak of GAstV, resulting in significant mortality among goslings due to the induction of gout-like symptoms. In our research, we successfully isolated a GAstV strain known as GAstV SCG3. This strain exhibits efficient replication capabilities, proving virulent in goslings and goose embryos...
February 28, 2024: Poultry Science
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