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Bowen's disease

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https://www.readbyqxmd.com/read/28930791/polydactylous-bowen-s-disease-in-an-immunocompromised-patient-resolution-of-all-lesions-after-mohs-surgery-on-a-single-lesion
#1
Nikita S Goel, Rajat Varma, Daniel C Zedek, Puneet S Jolly
No abstract text is available yet for this article.
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28904345/v%C3%AE-2-t-cell-response-to-malaria-correlates-with-protection-from-infection-but-is-attenuated-with-repeated-exposure
#2
Prasanna Jagannathan, Fredrick Lutwama, Michelle J Boyle, Felistas Nankya, Lila A Farrington, Tara I McIntyre, Katherine Bowen, Kate Naluwu, Mayimuna Nalubega, Kenneth Musinguzi, Esther Sikyomu, Rachel Budker, Agaba Katureebe, John Rek, Bryan Greenhouse, Grant Dorsey, Moses R Kamya, Margaret E Feeney
Vδ2(+) γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria. The role of these cells in mediating clinical immunity (i.e. protection against symptoms) to malaria remains unclear. We measured Vδ2(+) T cell absolute counts at acute and convalescent malaria timepoints (n = 43), and Vδ2(+) counts, cellular phenotype, and cytokine production following in vitro stimulation at asymptomatic visits (n = 377), among children aged 6 months to 10 years living in Uganda...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887507/carnosic-acid-prevents-dextran-sulfate-sodium-induced-acute-colitis-associated-with-the-regulation-of-the-keap1-nrf2-pathway
#3
Neng Yang, Zongling Xia, Naiyuan Shao, Bowen Li, Lian Xue, Ya Peng, Feng Zhi, Yilin Yang
Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBDs) with high prevalence in humans. Carnosic acid (CA) has been reported to possess antioxidative properties; however, its role in IBDs has not been determined. In the present study, we found that CA significantly prevented the loss of body weight and shortening of colon length in acute colitis induced by dextran sodium sulfate (DSS). Pronounced infiltration of immune cells and a loss of crypt architecture and goblet cells were ameliorated by CA...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887442/targeting-deficiencies-in-the-tlr5-mediated-vaginal-response-to-treat-female-recurrent-urinary-tract-infection
#4
Ased S M Ali, Catherine Mowbray, Marcelo Lanz, Anna Stanton, Samantha Bowen, Claire L Varley, Paul Hilton, Karen Brown, Wendy Robson, Jennifer Southgate, Phillip D Aldridge, Alison Tyson-Capper, Soman Abraham, Robert S Pickard, Judith Hall
The identification of the host defence peptides as target effectors in the innate defence of the uro-genital tract creates new translational possibilities for immunomodulatory therapies, specifically vaginal therapies to treat women suffering from rUTI, particularly those carrying the TLR5_C1174T SNP. Urinary tract infections (UTIs) are a microbial disease reported worldwide. Women are particularly susceptible with many suffering debilitating recurrent (r) infections. Treatment is by antibiotics, but such therapy is linked to antibiotic resistance and re-infection...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881739/a-phase-i-trial-of-azacitidine-and-nanoparticle-albumin-bound-paclitaxel-in-patients-with-advanced-or-metastatic-solid-tumors
#5
Adam L Cohen, Abhijit Ray, Matthew Van Brocklin, David M Burnett, Randy C Bowen, Donna L Dyess, Thomas W Butler, Theresa Dumlao, Hung T Khong
BACKGROUND: Secreted protein acidic and rich in cysteine (SPARC), an albumin-binding protein, is downregulated by hypermethylation in many cancers. Hypomethylating agents such as azacitidine can upregulate SPARC in tumors, which may enhance the accumulation of albumin-bound drugs at tumor site. The objectives of this phase I trial was to determine the safety and maximum tolerated dose and to assess any clinical activity of the combination of azacytidine and weekly nanoparticle-albumin-bound (nab®) paclitaxel...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28874075/congenital-heart-disease-a-primer-for-the-pediatric-neuropsychologist
#6
Adam R Cassidy, Dawn Ilardi, Susan R Bowen, Lyla E Hampton, Kimberley P Heinrich, Michelle M Loman, Jacqueline H Sanz, Kelly R Wolfe
Congenital heart disease (CHD) affects millions of people worldwide, including over one million children in the United States. Approximately 25% of children born with CHD require intensive surgical intervention within the first year of life. Despite improved rates of survival into adulthood - rates that exceed 90% in the modern era - children and adolescents with CHD remain at risk for neurological injury and a range of neurobehavioral and psychosocial challenges that pose a threat to quality of life across the lifespan...
September 6, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28867493/taking-the-defensive-immune-control-of-zika-virus-infection
#7
REVIEW
James R Bowen, Matthew G Zimmerman, Mehul S Suthar
ZIKV is a neurotropic mosquito-borne flavivirus that has recently emerged in the Americas and is a pathogen of significant public health concern across the world. ZIKV was first isolated in Uganda in 1947 and remained dormant in Africa and Asia for decades, with sporadic outbreaks characterized by a mild self-limiting disease in humans. The emergence of ZIKV in the Americas corresponded with enhanced disease severity and congenital Zika syndrome, a phenotype characterized by severe microcephaly, brain anomalies, ocular anomalies, congenital contractures and neurological impairments...
September 1, 2017: Virus Research
https://www.readbyqxmd.com/read/28862629/characterization-of-enamel-caries-lesions-in-rat-molars-using-synchrotron-x-ray-microtomography
#8
R D Free, K DeRocher, S R Stock, D Keane, K Scott-Anne, W H Bowen, D Joester
Dental caries is a ubiquitous infectious disease with a nearly 100% lifetime prevalence. Rodent caries models are widely used to investigate the etiology, progression and potential prevention or treatment of the disease. To explore the suitability of these models for deeper investigations of intact surface zones during enamel caries, the structures of early-stage carious lesions in rats were characterized and compared with previous reports on white spot enamel lesions in humans. Synchrotron X-ray microcomputed tomography non-destructively mapped demineralization in carious rat molar specimens across a range of caries severity, identifying 52 lesions across the 30 teeth imaged...
September 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28857056/health-risks-of-climate-change-in-the-world-health-organization-south-east-asia-region
#9
Kathryn J Bowen, Kristie L Ebi
Countries in the World Health Organization (WHO) South-East Asia Region are particularly vulnerable to a changing climate. Changes in extreme weather events, undernutrition and the spread of infectious diseases are projected to increase the number of deaths due to climate change by 2030, indicating the need to strengthen activities for adaptation and mitigation. With support from the WHO Regional Office for South-East Asia and others, countries have started to include climate change as a key consideration in their national public health policies...
September 2017: WHO South-East Asia Journal of Public Health
https://www.readbyqxmd.com/read/28844940/subclonal-evolution-of-cancer-related-gene-mutations-in-p53-immunopositive-patches-in-human-skin
#10
Amel A Albibas, Matthew J J Rose-Zerilli, Chester Lai, Reuben J Pengelly, Gabrielle A Lockett, Jeffrey Theaker, Sarah Ennis, John W Holloway, Eugene Healy
Normal sun-exposed skin contains numerous epidermal patches that stain positive for p53 protein (p53 immunopositive patches; PIPs), which are considered potential early precursors of skin cancer. Whilst the TP53 gene is mutated in many PIPs, it is unclear whether PIPs contain any other cancer-related mutations. Here we report that PIPs, predominantly <3,000 p53 immunopositive cells in size, within normal chronically exposed skin contain mutations in multiple genes which are mutated in cutaneous squamous cell cancers...
August 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28840749/evaluation-of-the-quality-of-life-in-patients-with-arsenic-keratosis
#11
Nazli Dizen Namdar, Inci Arikan, Cuneyt Kahraman, Emek Kocaturk, Merve Dagci, Ezgi Ece
BACKGROUND: Chronic exposure to inorganic arsenic is an important public health problem and leads to hyperpigmentation, hyperkeratosis, Bowen's disease and non-melanoma skin cancers in humans. Arsenic keratosis is the most common skin change that is associated with arsenic exposure. It may be an indicator of arsenic induced health hazards. OBJECTIVE: To determine the needs of patients with arsenic keratosis by evaluating the impact of disease on the quality of life with respect to treatment and provide rehabilitation services...
August 25, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28835840/coupling-gene-based-and-classic-veterinary-diagnostics-improves-interpretation-of-health-and-immune-function-in-the-agassiz-s-desert-tortoise-gopherus-agassizii
#12
K Kristina Drake, Lizabeth Bowen, Rebecca L Lewison, Todd C Esque, Kenneth E Nussear, Josephine Braun, Shannon C Waters, A Keith Miles
The analysis of blood constituents is a widely used tool to aid in monitoring of animal health and disease. However, classic blood diagnostics (i.e. hematologic and plasma biochemical values) often do not provide sufficient information to determine the state of an animal's health. Field studies on wild tortoises and other reptiles have had limited success in drawing significant inferences between blood diagnostics and physiological and immunological condition. However, recent research using gene transcription profiling in the threatened Mojave desert tortoise (Gopherus agassizii) has proved useful in identifying immune or physiologic responses and overall health...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28832993/what-s-new-in-dermoscopy-of-bowen-s-disease-two-new-dermoscopic-signs-and-its-differential-diagnosis
#13
Yi Yang, Jingrong Lin, Shifeng Fang, Shixin Han, Zhiqi Song
BACKGROUND: Clinical and dermoscopic features of Bowen's disease (BD) show great diversity. Some lesions of BD are often difficult to be differentiated from seborrheic keratosis, actinic keratosis, lichen planus-like keratosis, etc. It is necessary to fully describe the dermoscopic features of the disease, considering differential diagnosis. OBJECTIVE: To describe the dermoscopic feautres of Bowen's disease and summarize the dermoscopic differential diagnosis of the disease...
August 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28830420/a-randomised-controlled-two-centre-open-label-study-in-healthy-japanese-subjects-to-evaluate-the-effect-on-biomarkers-of-exposure-of-switching-from-a-conventional-cigarette-to-a-tobacco-heating-product
#14
Nathan Gale, Mike McEwan, Alison C Eldridge, Neil Sherwood, Edward Bowen, Simon McDermott, Emma Holmes, Andrew Hedge, Stuart Hossack, Oscar M Camacho, Graham Errington, John McAughey, James Murphy, Chuan Liu, Christopher J Proctor, Ian M Fearon
BACKGROUND: Smoking is a leading cause of numerous human disorders including lung cancer, chronic obstructive pulmonary disease, and atherosclerotic cardiovascular disease. The development of modified risk tobacco products (MRTPs) has been suggested as a possible way to reduce the risks of tobacco smoking by reducing exposure to cigarette smoke toxicants. This study is designed to investigate whether biomarkers of such exposure are reduced when smokers switch from smoking commercial cigarettes to using either a novel or a commercially-available tobacco heating product (THP)...
August 22, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28808837/a-multiparticulate-delivery-system-for-potential-colonic-targeting-using-bovine-serum-albumin-as-a-model-protein
#15
Bowen Jiang, Hua Yu, Yongrong Zhang, Hanping Feng, Stephen W Hoag
PURPOSE: There are many important diseases whose treatment could be improved by delivering a therapeutic protein to the colon, for example, Clostridium difficile infection, ulcerative colitis and Crohn's Disease. The goal of this project was to investigate the feasibility of colonic delivery of proteins using multiparticulate beads. METHODS: In this work, bovine serum albumin (BSA) was adopted as a model protein. BSA was spray layered onto beads, followed by coating of an enteric polymer EUDRAGIT® FS 30 D to develop a colonic delivery system...
August 14, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28806192/micrornas-as-biomarkers-in-chronic-kidney-disease
#16
Alexa Wonnacott, Timothy Bowen, Donald J Fraser
PURPOSE OF REVIEW: This review summarizes recent data supporting the concept that urinary microRNAs are a useful new class of biomarker. They may improve capacity to stratify patients with chronic kidney disease according to risk of progression, and may also inform about response to therapy. RECENT FINDINGS: MicroRNAs are present, stable and readily quantifiable in tissues and body fluids, including urine, and have widespread importance as regulators in the kidney...
August 12, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28802411/the-minipig-as-an-animal-model-to-study-mycobacterium-tuberculosis-infection-and-natural-transmission
#17
Laylaa Ramos, Andres Obregon-Henao, Marcela Henao-Tamayo, Richard Bowen, Joan K Lunney, Mercedes Gonzalez-Juarrero
In endemic countries more than 20% of tuberculosis (TB) cases are in infants and children. Current animal models study TB during adulthood but animal models for infant TB are scarce. Here we propose that minipigs can be used as an animal model to study adult, adolescent and infant TB including natural transmission. In these studies, two-month old minipigs (representing infant age in humans) and six-month old minipigs (representing adolescence in humans) were infected via the aerosol route with hyper-virulent clinical strain W-Beijing Mycobacterium tuberculosis (Mtb) HN878 and were monitored for 11 or 36 weeks post-challenge, respectively...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28800031/risk-factors-for-development-of-melanoma-brain-metastasis-and-disease-progression-a-single-center-retrospective-analysis
#18
Laura J Gardner, Morgan Ward, Robert H I Andtbacka, Kenneth M Boucher, Glen M Bowen, Tawnya L Bowles, Adam L Cohen, Kenneth Grossmann, Ying J Hitchcock, Sheri L Holmen, John Hyngstrom, Hung Khong, Martin McMahon, Marcus M Monroe, Carolyn B Ross, Gita Suneja, David Wada, Douglas Grossman
Melanoma metastasis to the brain is associated with a poor prognosis. We sought to determine patient demographics and primary tumor factors associated with the development of brain metastasis (BM) and survival. We also investigated whether the BM detection setting (routine screening vs. symptomatic presentation) affected clinical outcomes. A database of melanoma patients seen from 1999 to 2015 at our institution was reviewed to identify patients who developed BM. Patients with BM were matched by initial stage with patients who did not develop BM as a control group...
October 2017: Melanoma Research
https://www.readbyqxmd.com/read/28776197/long-term-exposure-of-immortalized-keratinocytes-to-arsenic-induces-emt-impairs-differentiation-in-organotypic-skin-models-and-mimics-aspects-of-human-skin-derangements
#19
R Weinmuellner, K Kryeziu, B Zbiral, K Tav, B Schoenhacker-Alte, D Groza, L Wimmer, M Schosserer, F Nagelreiter, S Rösinger, M Mildner, E Tschachler, M Grusch, J Grillari, P Heffeter
Arsenic is one of the most important human carcinogens and environmental pollutants. However, the evaluation of the underlying carcinogenic mechanisms is challenging due to the lack of suitable in vivo and in vitro models, as distinct interspecies differences in arsenic metabolism exist. Thus, it is of high interest to develop new experimental models of arsenic-induced skin tumorigenesis in humans. Consequently, aim of this study was to establish an advanced 3D model for the investigation of arsenic-induced skin derangements, namely skin equivalents, built from immortalized human keratinocytes (NHEK/SVTERT3-5)...
August 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28767028/-the-dutch-college-of-general-practitioners-practice-guideline-suspicious-skin-lesions
#20
Z Damen-van Beek, W Opstelten
- The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions' provides recommendations for diagnosis, treatment and referral for the most common premalignant and malignant skin disorders.- The practice guideline includes a flowchart which starts by looking at the colour and surface of the skin lesion to direct the general practitioner to the most likely diagnosis.- In case of strong suspicion of squamous cell carcinoma, keratoacanthoma or melanoma and in case of basal cell carcinoma or Bowen's disease with high-risk characteristics, the general practitioner will refer the patient to a dermatologist...
2017: Nederlands Tijdschrift Voor Geneeskunde
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