Amy Erica Lin, Aneesh C Bapat, Ling Xiao, Abhishek Niroula, Jianchuan Ye, Waihay J Wong, Mridul Agrawal, Christopher J Farady, Andreas Boettcher, Christopher B Hergott, Marie McConkey, Patricio Flores-Bringas, Veronica Shkolnik, Alexander G Bick, David Milan, Pradeep Natarajan, Peter Libby, Patrick T Ellinor, Benjamin L Ebert
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), a common age-associated phenomenon, associates with increased risk of both hematological malignancy and cardiovascular disease. Although CHIP is known to increase the risk of myocardial infarction and heart failure, the influence of CHIP in cardiac arrhythmias, such as atrial fibrillation (AF), is less explored. METHODS: CHIP prevalence was determined in the UK Biobank, and incident AF analysis was stratified by CHIP status and clone size using Cox proportional hazard models...
February 15, 2024: Circulation