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https://www.readbyqxmd.com/read/28208779/proof-of-concept-of-integrated-load-measurement-in-3d-printed-structures
#1
Michaël Hinderdael, Zoé Jardon, Margot Lison, Dieter De Baere, Wim Devesse, Maria Strantza, Patrick Guillaume
Currently, research on structural health monitoring systems is focused on direct integration of the system into a component or structure. The latter results in a so-called smart structure. One example of a smart structure is a component with integrated strain sensing for continuous load monitoring. Additive manufacturing, or 3D printing, now also enables such integration of functions inside components. As a proof-of-concept, the Fused Deposition Modeling (FDM) technique was used to integrate a strain sensing element inside polymer (ABS) tensile test samples...
February 9, 2017: Sensors
https://www.readbyqxmd.com/read/28207430/evaluation-of-augmented-pulse-pressure-variation-using-the-valsalva-manoeuvre-as-a-predictor-of-fluid-responsiveness-under-open-chest-conditions-a-prospective-observational-study
#2
Jeong Jin Min, Tae Kyong Kim, Jong-Hwan Lee, Jiyeon Park, Hyun Sung Cho, Wook Sung Kim, Young Tak Lee
BACKGROUND: Pulse pressure variation (PPV) is a well known dynamic preload indicator of fluid responsiveness. However, its usefulness in open-chest conditions remains controversial. OBJECTIVE: We evaluated whether augmented PPV during a Valsalva manoeuvre can predict fluid responsiveness after sternotomy. DESIGN: A prospective, observational study. SETTING: Single-centre trial, study period from October 2014 to June 2015...
February 15, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28205143/development-of-a-gastric-absorptive-immediate-responsive-oral-protein-loaded-versatile-polymeric-delivery-system
#3
Pierre P D Kondiah, Yahya E Choonara, Lomas K Tomar, Charu Tyagi, Pradeep Kumar, Lisa C du Toit, Thashree Marimuthu, Girish Modi, Viness Pillay
A multifunctional platform to deliver three diverse proteins of insulin, interferon beta (INF-β) and erythropoietin (EPO), using a novel copolymeric microparticulate system of TMC-PEGDMA-MAA, was synthesised as an intelligent pH-responsive 2-fold gastric and intestinal absorptive system. Physiochemical and physicomechanical studies proved the degree of crystallinity that supported the controlled protein delivery of the microparticulate system. The copolymer was tableted before undertaking in vitro and in vivo analysis...
February 15, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28198350/cerebrospinal-fluid-viral-load-and-neopterin-in-hiv-positive-patients-with-undetectable-viraemia
#4
Ilaria Motta, Tiziano Allice, Alessandra Romito, Micol Ferrara, Sara Ecclesia, Daniele Imperiale, Valeria Ghisetti, Giovanni Di Perri, Stefano Bonora, Andrea Calcagno
BACKGROUND: Cerebrospinal fluid (CSF) HIV RNA is commonly used as a marker of compartmental antiviral activity in HIV-positive patients. Undetectable CSF HIV RNA levels have been associated with low CSF neopterin levels and better neurocognitive performances. Aim of this study was to analyse the prevalence and predictors of non-detectable CSF HIV RNA using a commercial assay. METHODS: In adult HIV-positive HAART-treated patients with confirmed plasma HIV RNA <50 copies/mL, CSF HIV RNA (with Roche Amplicor Assay) and neopterin were measured...
February 15, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28196670/fluid-balance-and-chloride-load-in-the-first-24h-of-icu-admission-and-its-relation-with-renal-replacement-therapies-through-a-multicentre-retrospective-case-control-study-paired-by-apache-ii
#5
A González-Castro, M Ortiz-Lasa, O Leizaola, E Salgado, T Irriguible, M Sánchez-Satorra, C Lomas-Fernández, P Barral-Segade, M Cordero-Vallejo, E Rodrigo-Calabia, T Dierssen-Sotos
OBJECTIVE: To analyse the association between water balance during the first 24h of admission to ICU and the variables related to chloride levels (chloride loading, type of fluid administered, hyperchloraemia), with the development of acute kidney injury renal replacement therapy (AKI-RRT) during patients' admission to ICU. PATIENTS AND METHODS: Multicentre case-control study. Hospital-based, national, carried out in 6 ICUs. Cases were patients older than 18 years who developed an AKI-RRT...
February 10, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28196148/from-the-track-to-the-ocean-using-flow-control-to-improve-marine-bio-logging-tags-for-cetaceans
#6
Giovani Fiore, Erik Anderson, C Spencer Garborg, Mark Murray, Mark Johnson, Michael J Moore, Laurens Howle, K Alex Shorter
Bio-logging tags are an important tool for the study of cetaceans, but superficial tags inevitably increase hydrodynamic loading. Substantial forces can be generated by tags on fast-swimming animals, potentially affecting behavior and energetics or promoting early tag removal. Streamlined forms have been used to reduce loading, but these designs can accelerate flow over the top of the tag. This non-axisymmetric flow results in large lift forces (normal to the animal) that become the dominant force component at high speeds...
2017: PloS One
https://www.readbyqxmd.com/read/28196026/caffeine-inhibits-fluid-secretion-by-interlobular-ducts-from-guinea-pig-pancreas
#7
Yuka Mochimaru, Akiko Yamamoto, Miyuki Nakakuki, Makoto Yamaguchi, Ituka Taniguchi, Hiroshi Ishiguro
OBJECTIVES: Caffeine is contained in coffee, tea, and a lot of beverages and foods. We examined the direct effects of caffeine on the physiological function of pancreatic duct cells by using interlobular duct segments isolated from guinea pig pancreas. METHODS: The rate of fluid secretion was continuously measured by monitoring the luminal volume of isolated duct segments. Changes in intracellular Ca concentration ([Ca]i) were estimated by microfluorometry in ducts loaded with fura-2...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28192370/a-c3-h20-recycling-pathway-is-a-component-of-the-intracellular-complement-system
#8
Michelle Elvington, M Kathryn Liszewski, Paula Bertram, Hrishikesh S Kulkarni, John P Atkinson
An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores has not been rigorously investigated. In the present study, Western blotting identified a band corresponding to C3 in freshly isolated human peripheral blood cells that was absent in corresponding cell lines. One difference between native cells and cell lines was the time absent from a fluid-phase complement source; therefore, we hypothesized that loading C3 from plasma was a route of establishing intracellular C3 stores...
February 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28186507/one-year-real-world-outcomes-in-patients-receiving-fixed-dosing-aflibercept-for-neovascular-age-related-macular-degeneration
#9
H Almuhtaseb, S Kanavati, S R Rufai, A J Lotery
PurposeTo investigate 1-year visual and anatomic outcomes of intravitreal aflibercept for neovascular age-related macular degeneration (nAMD) given at a fixed 8-weekly interval.MethodsRetrospective, single-practice data analysis from an electronic medical record system of 255 eyes (223 patients) with treatment-naïve nAMD receiving 8-weekly aflibercept.ResultsMean logarithm of the minimum angle of resolution best-corrected visual acuity (BCVA) improved from 0.66 at baseline to 0.50 at month 11 (P<0.0001)...
February 10, 2017: Eye
https://www.readbyqxmd.com/read/28185360/effect-of-environmental-impedance-surrounding-a-radiofrequency-ablation-catheter-electrode-on-lesion-characteristics
#10
Duy T Nguyen, Kianna Nguyen, Lijun Zheng, Joseph Schuller, Matthew Zipse, Wendy S Tzou, William H Sauer
INTRODUCTION: The electrical conductivity of the environment surrounding a catheter electrode may affect radiofrequency (RF) current. A higher impedance environment enveloping a catheter tip can be insulating and thus direct RF preferentially into targeted cardiac tissue. We sought to evaluate whether different environmental impedances will affect RF lesions. METHODS: An ex vivo model using bovine myocardium, load cell, and 4 mm ablation catheter was tested using a circulating bath of normal (0...
February 10, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28183604/wear-behaviour-of-uhmwpe-reinforced-by-carbon-nanofiller-and-paraffin-oil-for-joint-replacement
#11
Samy Yousef, Annamaria Visco, Giovanna Galtieri, Davide Nocita, Claudia Espro
The majority of artificial joints incorporate biomedical grade Ultra High Molecular Weight Poly Ethylene (UHMWPE), whose wear is considered most important in controlling service time of the whole joint. The aim of this work was to improve wear resistance of UHMWPE through the addition of 0.5-2.0wt% of Carbon Nano Filler (CNF) and 2% wt of Paraffin Oil (PO) using ball milling (BM) and extrusion techniques (EX). The wear tests on these nanocomposites were conducted by a pin on disc in dry (air) and wet media (simulated synovial fluid or artificial lubricant, and bovine synovial fluid or natural lubricant)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183565/minimum-effective-fluid-volume-of-colloid-to-prevent-hypotension-during-caesarean-section-under-spinal-anesthesia-using-a-prophylactic-phenylephrine-infusion-an-up-down-sequential-allocation-study
#12
Christian Loubert, Pierre-Olivier Gagnon, Roshan Fernando
STUDY OBJECTIVE: The aim of this study was to de termine the minimum effective fluid volume (MEFV) of hydroxyethyl starch 130/0.4 (HES) infused in a preload fashion which would prevent hypotension in 50% of parturients undergoing caesarean section. A secondary objective was to measure the hemodynamic effect of fluid loading on the subjects. DESIGN: This is a prospective, double-blinded, dose-finding study using an up-down sequential allocation design. SETTING: In the operating room...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28181795/water-responsive-shape-recovery-induced-buckling-in-biodegradable-photo-cross-linked-poly-ethylene-glycol-peg-hydrogel
#13
Abhijit Vijay Salvekar, Wei Min Huang, Rui Xiao, Yee Shan Wong, Subbu S Venkatraman, Kiang Hiong Tay, Ze Xiang Shen
The phenomenon of recovering the permanent shape from a severely deformed temporary shape, but only in the presence of the right stimulus, is known as the shape memory effect (SME). Materials with such an interesting effect are known as shape memory materials (SMMs). Typical stimuli to trigger shape recovery include temperature (heating or cooling), chemical (including water/moisture and pH value), and light. As a SMM is able not only to maintain the temporary shape but also to respond to the right stimulus when it is applied, via shape-shifting, a seamless integration of sensing and actuation functions is achieved within one single piece of material...
February 9, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28177597/zero-order-antibiotic-release-from-multilayer-contact-lenses-nonuniform-drug-and-diffusivity-distributions-produce-constant-rate-drug-delivery
#14
Gustavo Guzman, Siamak Shams Es-Haghi, Turgut Nugay, Mukerrem Cakmak
A novel approach to zero-order constant-rate drug delivery from contact lenses is presented. Quasi-Case II non-Fickian transport is achieved by nonuniform drug and diffusivity distributions within three-layer bimodal amphiphilic conetworks (β-APCNs). The center layer is a highly oxygen permeable β-APCN matrix, which contains the drug and exhibits a high drug diffusivity. The outer β-APCN layers contain no-drug and are loaded with vitamin E, which slows diffusion. In contrast to single-layer neat-polymer and vitamin E-loaded films that display first-order "burst" kinetics, it is demonstrated experimentally and by modeling that the combined effect of nonuniform distribution of drug loading and diffusion constants within the three-layer lens maintains low local drug concentration at the lens-fluid interface and yields zero-order drug delivery...
February 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28160738/on-the-mechanical-behaviour-of-peek-and-ha-cranial-implants-under-impact-loading
#15
D Garcia-Gonzalez, J Jayamohan, S N Sotiropoulos, S-H Yoon, J Cook, C R Siviour, A Arias, A Jérusalem
The human head can be subjected to numerous impact loadings such as those produced by a fall or during sport activities. These accidents can result in skull fracture and in some complex cases, part of the skull may need to be replaced by a biomedical implant. Even when the skull is not damaged, such accidents can result in brain swelling treated by decompressive craniectomy. Usually, after recovery, the part of the skull that has been removed is replaced by a prosthesis. In such situations, a computational tool able to analyse the choice of prosthesis material depending on the patient's specific activity has the potential to be extremely useful for clinicians...
January 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28159434/-and-if-it-happened-to-children-adapting-medical-care-during-terrorist-attacks-with-multiple-pediatric-victims
#16
L Alix-Séguin, N Lodé, G Orliaguet, E Chamorro, F Kerroué, C Lorge, A Moreira
In light of the recent terrorist attacks in Europe, we need to reconsider the organization of rescue and medical management and plan for an attack involving multiple pediatric victims. To ensure quick surgical management, but also to minimize risk for on-site teams (direct threats from secondary terrorist attacks targeting deployed emergency services), it is crucial to evacuate patients in a swift but orderly fashion. Children are vulnerable targets in terrorist attacks. Their anatomical and physiological characteristics make it likely that pediatric victims will suffer more brain injuries and require more, often advanced, airway management...
January 31, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28158970/tumor-necrosis-factor-alpha-inhibitors-have-no-effect-on-a-human-t-lymphotropic-virus-type-i-htlv-i-infected-cell-line-from-patients-with-htlv-i-associated-myelopathy
#17
Shoichi Fukui, Hideki Nakamura, Yoshiko Takahashi, Naoki Iwamoto, Hiroo Hasegawa, Katsunori Yanagihara, Tatsufumi Nakamura, Akihiko Okayama, Atsushi Kawakami
BACKGROUND: While tumor necrosis factor alpha (TNF-α) inhibitors (TNFi) and other biologics are very effective against autoimmune diseases, they can also cause infectious diseases. Therefore, it is important to clarify whether the TNFi sometimes used to treat patients with rheumatoid arthritis (RA) complicated with human T-lymphotropic virus type-I (HTLV-I) infection have the unintended side effect of promoting HTLV-I proliferation. METHODS: We used the HTLV-I-infected cell line HCT-5, derived from spinal fluid cells of a patient with HTLV-I associated myelopathy, to evaluate the production of cytokines and chemokines, TNF-α receptor (TNFR), the expression of HTLV-I associated genes, the HTLV-I proviral load (PVL), the expression of HTLV-I structural protein, and apoptosis...
February 3, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28157238/resealable-optically-accessible-pdms-free-fluidic-platform-for-ex-vivo-interrogation-of-pancreatic-islets
#18
Giovanni Lenguito, Deborah Chaimov, Jonathan R Weitz, Rayner Rodriguez-Diaz, Siddarth A K Rawal, Alejandro Tamayo-Garcia, Alejandro Caicedo, Cherie L Stabler, Peter Buchwald, Ashutosh Agarwal
We report the design and fabrication of a robust fluidic platform built out of inert plastic materials and micromachined features that promote optimized convective fluid transport. The platform is tested for perfusion interrogation of rodent and human pancreatic islets, dynamic secretion of hormones, concomitant live-cell imaging, and optogenetic stimulation of genetically engineered islets. A coupled quantitative fluid dynamics computational model of glucose stimulated insulin secretion and fluid dynamics was first utilized to design device geometries that are optimal for complete perfusion of three-dimensional islets, effective collection of secreted insulin, and minimization of system volumes and associated delays...
February 3, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28155729/mechanical-regulation-of-calcium-signaling-of-hl-60-on-p-selectin-under-flow
#19
Bing Huang, Yingchen Ling, Jiangguo Lin, Ying Fang, Jianhua Wu
BACKGROUND: Binding of P-selectin to P-selectin glycoprotein ligand-1 (PSGL-1) makes neutrophils roll on and adhere to inflammatory site. Intracellular calcium bursting of adhered neutrophils is a key event for subsequent arresting firmly at and migrating into the injured tissue. But, it remains unclear how the cytoplasmic calcium signaling of the cells were modulated by the fluid shear stress. Here, we focus on mechanical regulation of P-selectin-induced calcium signaling of neutrophil-like HL-60 cells under flow...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155688/mathematically-modeling-fluid-flow-and-fluid-shear-stress-in-the-canaliculi-of-a-loaded-osteon
#20
Xiaogang Wu, Ningning Wang, Zhaowei Wang, Weilun Yu, Yanqin Wang, Yuan Guo, Weiyi Chen
BACKGROUND: Mechanical load-induced intraosseous pressure gradients may result in some fluid stimuli effects, such as fluid flow and fluid shear stress (FSS), which may enable bone cells to detect external mechanical signals. Interstitial bone fluid flow is known to occur in lacunar-canalicular porosity (PLC). METHODS: In order to characterize lacunar-canalicular fluid flow behavior, a hierarchical osteon system is developed. The osteon is modeled as a poroelastic annular cylinder with two types of impermeable boundary cases considered on its outer wall: one is elastic restrained (Case I), whereas the other is displacement confined (Case II)...
December 28, 2016: Biomedical Engineering Online
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