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https://www.readbyqxmd.com/read/28532282/synthesis-of-ph-responsive-n-acetyl-cysteine-modified-starch-derivatives-for-oral-delivery
#1
Kwanghyok Jong, Benzhi Ju, Shufen Zhang
In this study, a novel type of pH-responsive polymer PyHES-NAC ((2-hydroxy-3-(2-propynyloxy) propyl hydroxyethyl starch (PyHES)) - (N-Acetyl-cysteine (NAC)) was synthesized. First, PyHES was prepared via hydrophobic modification of hydroxyl groups in hydroxyethyl starch (HES) with propynylglycidyl ether (PGE), and then pH-responsive carboxylic acid group was connected to propynyl group via thiol-yne click reaction with NAC. Aqueous PyHES-NAC solutions exhibited a good transference between hydrophobic (or self-assembly) and hydrophilic static along with the change of pH value and protective properties of drugs under acidic conditions...
May 22, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28532085/mesoporous-nano-bioglass-designed-for-the-release-of-imatinib-and-in-vitro-inhibitory-effects-on-cancer-cells
#2
Muhammad Shoaib, Aamer Saeed, Muhammad Saif Ur Rahman, Muhammad Moazzam Naseer
For treating bone cancer, controlled drug delivery is an important strategy. Bioactive scaffolds are widely used biomaterials due to their usefulness in localized drug delivery. The aim of this study was to develop mesoporous bioglass (MBG) with improved bioactivity and controllable drug delivery rate. By using pluronic 123 (P123) as a template, a facile sol-gel route was employed for the synthesis of MBG nanoparticles (NPs). The composition of the prepared sample was estimated by using energy dispersive X-ray spectroscopy (EDX)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532039/bioactivity-mechanical-properties-and-drug-delivery-ability-of-bioactive-glass-ceramic-scaffolds-coated-with-a-natural-derived-polymer
#3
M Araújo, R Viveiros, A Philippart, M Miola, S Doumett, G Baldi, J Perez, A R Boccaccini, A Aguiar-Ricardo, E Verné
In this work, hybrid melanin-coated bioactive glass-ceramic multifunctional scaffolds were developed and characterized in terms of mechanical strength, in vitro bioactivity in simulated body fluid (SBF) and ability to load ibuprofen. The coated scaffolds exhibited an accelerated bioactivity in comparison with the uncoated ones, being able of developing hydroxyapatite-like crystals after 7days soaking in simulated body fluid (SBF). Besides its positive influence on the scaffolds bioactivity, the melanin coating was able to enhance their mechanical properties, increasing the initial compressive strength by a factor of >2...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530202/effect-of-age-and-blood-pressure-on-determination-of-normal-fluid-status-in-a-general-population-using-whole-body-and-calf-bioimpedance-techniques
#4
Fansan Zhu, Samer R Abbas, Peter Kotanko, Nathan W Levin
Normal fluid status (dry weight) can be identified by hydration markers established in the healthy population. The general population average could be influenced by age with its accompanying physiological changes and/or illness. The aims of this study were (1) to evaluate the effect of age and systolic blood pressure (SBP) on these markers; (2) to compare mean values of hydration markers as assessed by different bioimpedance techniques. Subjects from the general population (n  =  212, males 105, 57...
June 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28530194/solvent-effect-in-the-synthesis-of-hydrophobic-drug-loaded-polymer-nanoparticles
#5
Sandip Pal, Chabita Saha
Quercetin is an abundant flavonoid in fruits, vegetables such as onion, tea leaves, cranberry, radish leaves etc. with numerous biological activities and widely used as an effective antioxidant. Its low solubility in water and chemical decomposition in intestinal environment are predicaments in delivery through dietary or oral intake. Noble polymeric nanoparticles are of particular interest today because of their applications in many areas. Polymer nanoparticles have attracted the interest of many research groups and have been utilised in an increasing number of fields such as site targeted drug delivery in cancer research during the last decades...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28529763/characterisation-of-a-novel-poly-ether-ether-ketone-calcium-sulphate-composite-for-bone-augmentation
#6
Erik A B Hughes, Liam M Grover
BACKGROUND: Calcium sulphate (CS) has been used in bone grafting since the 1800s. It has not replaced autograft as the gold standard, however, since its dissolution occurs rapidly in bodily fluids, meaning that the material cannot support long-term bone growth. Here, the polymer poly (ether ether ketone) (PEEK) was used to slow dissolution in in vitro physiological environments and augment the mechanical properties of the material. METHODS: PEEK/CS specimens were fabricated by combining powders of PEEK and CS with water, resulting in a hardening paste...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28528112/microencapsulation-and-characterization-of-liposomal-vesicles-using-a-supercritical-fluid-process-coupled-with-vacuum-driven-cargo-loading
#7
Wen-Chyan Tsai, Syed S H Rizvi
A new technique of liposomal microencapsulation, consisting of supercritical fluid extraction followed by rapid expansion of the supercritical solution and vacuum-driven cargo loading, was successfully developed. It is a continuous flow-through process without usage of any toxic organic solvent. For use as a coating material, the solubility of soy phospholipids in supercritical carbon dioxide was first determined using a dynamic equilibrium system and the data was correlated with the Chrastil model with good agreement...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28526086/comparison-of-fluid-balance-and-hemodynamic-and-metabolic-effects-of-sodium-lactate-versus-sodium-bicarbonate-versus-0-9-nacl-in-porcine-endotoxic-shock-a-randomized-open-label-controlled-study
#8
Thibault Duburcq, Arthur Durand, Anne-Frédérique Dessein, Joseph Vamecq, Jean-Claude Vienne, Dries Dobbelaere, Karine Mention, Claire Douillard, Patrice Maboudou, Valery Gmyr, François Pattou, Mercé Jourdain, Fabienne Tamion, Julien Poissy, Daniel Mathieu, Raphaël Favory
BACKGROUND: Sodium lactate has been shown to improve hemodynamics and avoid fluid overload. The objective of this study was to confirm a beneficial effect on fluid balance with sodium lactate infusion and to specify whether the advantage of lactate is related to a negative chloride balance, its particular metabolism, or simply its energy load. METHODS: This was an interventional, randomized, open-label, controlled experimental study. Fifteen female "large white" pigs (2 months old) were challenged with intravenous infusion of Escherichia coli endotoxin...
May 19, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28525497/enhanced-recovery-after-surgery-for-suspected-ovarian-malignancy-a-survey-of-perioperative-practice-among-gynecologic-oncologists-in-australia-and-new-zealand-to-inform-a-clinical-trial
#9
Kristina Lindemann, Peey-Sei Kok, Martin Stockler, Peter Sykes, Alison Brand
OBJECTIVES: The objective of this survey was to review the current standard of perioperative care of patients with suspected advanced ovarian cancer in Australia and New Zealand in order to determine the level of equipoise for specific interventions. METHODS: In May 2016, a web-based questionnaire (SurveyMonkey Inc, Palo Alto, CA) was sent to all gynecologic oncologists in Australia and New Zealand (n = 56). Descriptive statistics were used. RESULTS: Response rate was 75%...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28521277/the-spatio-temporal-mechanical-environment-of-healthy-and-injured-human-cartilage-during-sustained-activity-and-its-role-in-cartilage-damage
#10
Saeed Miramini, David W Smith, Lihai Zhang, Bruce S Gardiner
Recently we presented a computational model of articular cartilage calibrated for normal human tissue explants. This model was able to capture the transient deformation of cartilage experiencing a cyclic load. The model takes into account the tension-compression nonlinearity of the cartilage and incorporates the dependency of the compressive stiffness and fluid permeability of cartilage on the deformation-dependent aggrecan concentration in cartilage tissue. As such it represents a leading constitutive model of articular cartilage...
May 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28521202/dual-growth-factor-loaded-nonmulberry-silk-fibroin-carbon-nanofiber-composite-3d-scaffolds-for-in%C3%A2-vitro-and-in%C3%A2-vivo-bone-regeneration
#11
Deboki Naskar, Ananta K Ghosh, Mahitosh Mandal, Piyali Das, Samit K Nandi, Subhas C Kundu
In recent years the potential application of nanocomposite biomaterials in tissue engineering field is gaining importance because of the combined features of all the individual components. A bottom-up approach is acquired in this study to recreate the bone microenvironment. The regenerated silk protein fibroin obtained from nonmulberry tropical tasar Antheraea mylitta species is reinforced with functionalized carbon nano fiber (CNF) and the composite sponges are fabricated using facile green aqueous based method...
May 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/28516401/endovascular-crossing-of-chronic-total-occlusions-using-an-impulse-an-explorative-design-study
#12
Aimée Sakes, Marleen van der Wiel, Dimitra Dodou, Paul Breedveld
In this study we investigated whether exerting an impulse on a Chronic Total Occlusion (CTO) improves the success rate of CTO crossing as compared to the currently used method of statically pushing the guidewire against the CTO. A prototype (Ø2 mm) was developed that generates translational momentum using a spring-loaded indenter and converts it to an impulse during impact. Mechanical performance was evaluated by measuring the peak force and momentum for different spring compressions and strike distances in air and blood-mimicking fluid...
May 17, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28513889/mechanically-induced-bone-formation-is-not-sensitive-to-local-osteocyte-density-in-rat-vertebral-cancellous-bone
#13
Erin N Cresswell, Thu M Nguyen, Michael W Horsfield, Adrian J Alepuz, Thomas A Metzger, Glen L Niebur, Christopher J Hernandez
Osteocytes play an integral role in bone by sensing mechanical stimuli and releasing signaling factors that direct bone formation. The importance of osteocytes in mechanotransduction suggests that regions of bone tissue with greater osteocyte populations are more responsive to mechanical stimuli. To determine the effects of osteocyte population on bone functional adaptation we applied mechanical loads to the 8(th) caudal vertebra of skeletally mature female Sprague Dawley rats (6 months of age, n = 8 loaded, n = 8 sham controls)...
May 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28513810/epstein-barr-virus-encephalitis-in-solid-organ-transplantation
#14
Jillian S Y S Y, Zhi Mei Low, Iain Abbott, Lani Shochet, John Kanellis, Richard A Kitching, Tony M Korman
Epstein-Barr virus (EBV) is typically associated with post transplant lymphoproliferative disease (PTLD) after solid organ and stem cell transplantation. However, it is rarely associated with neurological complications. We report a case of severe encephalitis complicating primary EBV infection six months post renal transplantation, and review the literature on EBV encephalitis in solid organ transplantation in adults. A 55-year-old male presented 6 months post cadaveric renal transplant with headache, fever and confusion...
May 17, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28509130/acute-pulmonary-thromboembolism-occurring-during-treatment-with-tolvaptan-in-a-patient-with-autosomal-dominant-polycystic-kidney-disease
#15
Katsuhiko Morimoto, Yasuhiro Akai, Masaru Matsui, Hiroki Yano, Miho Tagawa, Ken-Ichi Samejima, Yoshihiko Saito
Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent cystic kidney disease, with approximately half of the patients reaching end-stage renal disease by the age of 60. Tolvaptan prevents renal cyst growth by inhibiting intracellular cyclic AMP and is recommended for patients with ADPKD. Reports of thrombotic complications with tolvaptan have been limited. We report a case of a 60-year-old man who developed thromboembolisms during tolvaptan treatment for ADPKD. The patient started tolvaptan in July 2014...
May 2017: CEN Case Reports
https://www.readbyqxmd.com/read/28508517/on-demand-antimicrobial-treatment-with-antibiotic-loaded-porous-silicon-capped-with-a-ph-responsive-dual-plasma-polymer-barrier
#16
Roshan Bharath Vasani, Endre J Szili, Gayathri Rajeev, Nicolas Hans Voelcker
Chronic wounds are a major socio-economic problem. Bacterial infections in such wounds are a major contributor to lack of wound healing. An early indicator of wound infection is an increase in pH of the wound fluid. Herein, we describe the development of a pH-responsive drug delivery device that can potentially be used for wound decontamination in situ and on-demand in response to an increase in the pH of the wound environment. The device is based on a porous silicon film that provides a reservoir for encapsulation of an antibiotic within the pores...
May 16, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28508006/early-osteoarthritis-after-untreated-anterior-meniscal-root-tears-an-in-vivo-animal-study
#17
Brett D Steineman, Robert F LaPrade, Kelly S Santangelo, Brent T Warner, Laurie R Goodrich, Tammy L Haut Donahue
BACKGROUND: Meniscal root tears cause menisci and their insertions to inadequately distribute loads and potentially leave underlying articular cartilage unprotected. Untreated meniscal root tears are becoming increasingly recognized to induce joint degradation; however, little information is known about anterior meniscal root tears and how they affect joint tissue. PURPOSE: To observe the early degenerative changes within the synovial fluid, menisci, tibial articular cartilage, and subchondral bone after arthroscopic creation of untreated anterior meniscal root tears...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28506136/predictors-to-intravenous-fluid-responsiveness
#18
Jorge Iván Alvarado Sánchez, William Fernando Amaya Zúñiga, Manuel Ignacio Monge García
Management with intravenous fluids can improve cardiac output in some surgical patients. Management with static preload indicators, such as central venous pressure and pulmonary artery occlusion pressure, has not demonstrated a suitable relationship with changes in the cardiac output induced by intravenous fluid therapy. Dynamic indicators, such as the variability of arterial pulse pressure or stroke volume variation, have demonstrated a suitable relationship. Since improvement in cardiac output does not guarantee an adequate perfusion pressure, in patients with hypotension, it is also necessary to know whether arterial pressure will also increase with intravenous fluid therapy...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28505841/optimal-strengthening-of-particle-loaded-liquid-foams
#19
F Gorlier, Y Khidas, A Fall, O Pitois
Foams made of complex fluids such as particle suspensions have a great potential for the development of advanced aerated materials. In this paper, we study the rheological behavior of liquid foams loaded with granular suspensions. We focus on the effect of small particles, i.e., particle-to-bubble size ratio smaller than 0.1, and we measure the complex modulus as a function of particle size and particle volume fraction. With respect to previous work, the results highlight a new elastic regime characterized by unequaled modulus values as well as independence of size ratio...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28504263/dehydration-driven-stress-transfer-triggers-intermediate-depth-earthquakes
#20
Thomas P Ferrand, Nadège Hilairet, Sarah Incel, Damien Deldicque, Loïc Labrousse, Julien Gasc, Joerg Renner, Yanbin Wang, Harry W Green Ii, Alexandre Schubnel
Intermediate-depth earthquakes (30-300 km) have been extensively documented within subducting oceanic slabs, but their mechanics remains enigmatic. Here we decipher the mechanism of these earthquakes by performing deformation experiments on dehydrating serpentinized peridotites (synthetic antigorite-olivine aggregates, minerals representative of subduction zones lithologies) at upper mantle conditions. At a pressure of 1.1 gigapascals, dehydration of deforming samples containing only 5 vol% of antigorite suffices to trigger acoustic emissions, a laboratory-scale analogue of earthquakes...
May 15, 2017: Nature Communications
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