Thomas J Sandora, Larry K Kociolek, David N Williams, Kaitlyn Daugherty, Christine Geer, Christine Cuddemi, Xinhua Chen, Hua Xu, Timothy J Savage, Alice Banz, Kevin W Garey, Anne J Gonzales-Luna, Ciarán P Kelly, Nira R Pollock
BACKGROUND: In adults with Clostridioides difficile infection (CDI), higher stool concentrations of toxins A and B are associated with severe baseline disease, CDI-attributable severe outcomes, and recurrence. We evaluated whether toxin concentration predicts these presentations in children with CDI. METHODS: We conducted a prospective cohort study of inpatients aged 2-17 years with CDI who received treatment. Patients were followed for 40 days after diagnosis for severe outcomes (intensive care unit admission, colectomy, or death, categorized as CDI primarily attributable, CDI contributed, or CDI not contributing) and recurrence...
January 10, 2023: Infection Control and Hospital Epidemiology