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https://www.readbyqxmd.com/read/28335261/nanomaterials-for-cardiac-myocyte-tissue-engineering
#1
REVIEW
Rodolfo Amezcua, Ajay Shirolkar, Carolyn Fraze, David A Stout
Since their synthesizing introduction to the research community, nanomaterials have infiltrated almost every corner of science and engineering. Over the last decade, one such field has begun to look at using nanomaterials for beneficial applications in tissue engineering, specifically, cardiac tissue engineering. During a myocardial infarction, part of the cardiac muscle, or myocardium, is deprived of blood. Therefore, the lack of oxygen destroys cardiomyocytes, leaving dead tissue and possibly resulting in the development of arrhythmia, ventricular remodeling, and eventual heart failure...
July 19, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28331015/association-between-clinically-recorded-alcohol-consumption-and-initial-presentation-of-12-cardiovascular-diseases-population-based-cohort-study-using-linked-health-records
#2
Steven Bell, Marina Daskalopoulou, Eleni Rapsomaniki, Julie George, Annie Britton, Martin Bobak, Juan P Casas, Caroline E Dale, Spiros Denaxas, Anoop D Shah, Harry Hemingway
Objectives To investigate the association between alcohol consumption and cardiovascular disease at higher resolution by examining the initial lifetime presentation of 12 cardiac, cerebrovascular, abdominal, or peripheral vascular diseases among five categories of consumption.Design Population based cohort study of linked electronic health records covering primary care, hospital admissions, and mortality in 1997-2010 (median follow-up six years).Setting CALIBER (ClinicAl research using LInked Bespoke studies and Electronic health Records)...
March 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28329083/impact-of-a-public-awareness-campaign-on-out-of-hospital-cardiac-arrest-incidence-and-mortality-rates
#3
Ziad Nehme, Emily Andrew, Stephen Bernard, Harry Patsamanis, Peter Cameron, Janet E Bray, Ian T Meredith, Karen Smith
Aims: Increased public awareness of the warning signs of a heart attack and the importance of early medical intervention may help to prevent premature deaths from out-of-hospital cardiac arrest (OHCA). We sought to investigate the impact of the Heart Foundation's public awareness campaigns on the monthly incidence of, and deaths from, OHCA in Melbourne, Australia. Methods and results: Between July 2005 and June 2015, we included registry data for 25 060 OHCA of presumed cardiac aetiology...
November 2, 2016: European Heart Journal
https://www.readbyqxmd.com/read/28325641/spectrum-of-nondystrophic-skeletal-muscle-channelopathies-in-children
#4
Fouad Al-Ghamdi, Basil T Darras, Partha S Ghosh
BACKGROUND: The nondystrophic skeletal muscle channelopathies are a group of disorders caused by mutations of various voltage-gated ion channel genes, including nondystrophic myotonia and periodic paralysis. METHODS: We identified patients with a diagnosis of muscle channelopathy from our neuromuscular database in a tertiary care pediatric center from 2005 to 2015. We then performed a retrospective review of their medical records for demographic characteristics, clinical features, investigations, treatment, and follow-up...
February 16, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28320749/sex-differences-in-percutaneous-coronary-intervention-insights-from-the-coronary-angiography-and-pci-registry-of-the-german-society-of-cardiology
#5
Tobias Heer, Matthias Hochadel, Karin Schmidt, Julinda Mehilli, Ralf Zahn, Karl-Heinz Kuck, Christian Hamm, Michael Böhm, Georg Ertl, Hans Martin Hoffmeister, Stefan Sack, Jochen Senges, Steffen Massberg, Anselm K Gitt, Uwe Zeymer
BACKGROUND: Several studies have suggested sex-related differences in diagnostic and invasive therapeutic coronary procedures. METHODS AND RESULTS: Data from consecutive patients who were enrolled in the Coronary Angiography and PCI Registry of the German Society of Cardiology were analyzed. We aimed to compare sex-related differences in in-hospital outcomes of patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease, non-ST elevation acute coronary syndromes, ST elevation myocardial infarction, and cardiogenic shock...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28303103/multipronged-therapeutic-effects-of-chinese-herbal-medicine-qishenyiqi-in-the-treatment-of-acute-myocardial-infarction
#6
Yong Wang, Weili Lin, Chun Li, Sarita Singhal, Gaurav Jain, Lixin Zhu, Linghui Lu, Ruixin Zhu, Wei Wang
Background: Based on global gene expression profile, therapeutic effects of Qishenyiqi (QSYQ) on acute myocardial infarction (AMI) were investigated by integrated analysis at multiple levels including gene expression, pathways involved and functional group. Methods: Sprague-Dawley (SD) rats were randomly divided into 3 groups: Sham-operated, AMI model (left anterior descending coronary artery ligation) and QSYQ-treated group. Cardiac tissues were obtained for analysing digital gene expression. Sequencing and transcriptome analyses were performed collaboratively, including analyses of differential gene expression, gene co-expression network, targeted attack on network and functional grouping...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28302764/-18-f-gp1-a-novel-fluorine-18-labeled-tracer-designed-for-pet-imaging-of-thrombi-with-high-detection-sensitivity-and-low-background
#7
Jessica Lohrke, Holger Siebeneicher, Markus Berger, Michael Reinhardt, Mathias Berndt, Andre Mueller, Marion Zerna, Norman Koglin, Felix Oden, Marcus Bauser, Matthias Friebe, Ludger M Dinkelborg, Joachim Huetter, Andrew W Stephens
Thromboembolic diseases such as myocardial infarction, stroke, transient ischemic attacks and pulmonary embolism are major causes of morbidity and mortality worldwide. GPIIb/IIIa is the key receptor involved in platelet aggregation and is a validated target for therapeutic approaches and diagnostic imaging. The aim of this study was to develop and characterize a specific small molecule tracer for positron emission tomography (PET) imaging that binds with high affinity to GPIIb/IIIa receptors and has suitable pharmacokinetic properties to overcome limitations of previous approaches...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28290814/-assessment-of-the-impact-of-nicorandil-on-the-quality-of-life-and-prognosis-indicators-in-patients-with-stable-angina
#8
Ryabikhin Ryabikhin, M E Mozheiko, Y Krasilnikova
OBJECTIVE: To study the effect of nicorandil on the elasticity of the great vessels, cardiac functional parameters and quality of life in patients with coronary heart disease (CHD). MATERIAL AND METHODS: In a double-blind, randomized, placebo-controlled trial of nicorandil was attended by 154 patients with stable angina III functional class (FC), divided into 2 comparable age and sex group. Study duration was 12 months. RESULTS: In the group treated with nicorandil compared with placebo, the number of angina attacks and nitrate intake of short-significantly reduced, improved elastic properties of large arteries, improved quality of life...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28286854/recurrent-syncope-following-substance-abuse-a-case-report
#9
Forod Salehi, Mohammad Mehdi Hassanzadeh Taheri, HamidReza Riasi, Omid Mehrpour
Drug abuse is considered as the most common poisoning in the world. Stimulants agent especially amphetamines and methamphetamines are among important abused substances. Different types of neurologic, psychiatric, respiratory, gastrointestinal, and cardiogenic complications have been reported to be related to methamphetamine consumption. Some of these substances could cause dysrhythmias which is the most prevalent etiology of cardiogenic syncope. Ecstasy, as one of the most commonly abused drugs, is known as a cause of cardiac dysrhythmias...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28285088/impact-of-multiple-chronic-conditions-in-patients-hospitalized-with-stroke-and-transient-ischemic-attack
#10
Mohammed Yousufuddin, Adam C Bartley, Mouaz Alsawas, Heather L Sheely, Jessica Shultz, Paul Y Takahashi, Nathan P Young, M Hassan Murad
BACKGROUND: The prevalence and clinical impact of chronic conditions (CCs) have increasingly been recognized as an important public health concern. We evaluated the prevalence of coexisting CCs and their association with 30-day mortality and readmission in hospitalized patients with stroke and transient ischemic attack (TIA). METHODS: In a retrospective study of patients aged ≥18 years hospitalized for first-ever stroke and TIA, we assessed the prevalence of coexisting CCs and their predictive value for subsequent 30-day mortality and readmission...
March 8, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28281270/liposome-enhanced-lateral-flow-assays-for-clinical-analyses
#11
Katie A Edwards, Ricki Korff, Antje J Baeumner
Clinical and environmental analyses frequently necessitate rapid, simple, and inexpensive point-of-care or field tests. These semiquantitative tests may be later followed up by confirmatory laboratory-based assays, but provide an initial scenario assessment important for resource mobilization and threat confinement. Lateral-flow assays (LFAs) and dip-stick assays, which are typically antibody-based and yield a visually detectable signal, provide an assay format suiting these applications extremely well. Signal generation is commonly obtained through the use of colloidal gold or latex beads, which yield a colored band either directly proportional or inversely proportional to the concentration of the analyte of interest...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28275419/early-diagnosis-and-treatment-of-coronary-heart-disease-in-symptomatic-subjects-with-advanced-vascular-atherosclerosis-of-the-carotid-artery-type-iii-and-iv-b-findings-using-ultrasound
#12
Ansgar Adams, Waldemar Bojara, Klaus Schunk
BACKGROUND: A study was conducted as to whether the early diagnosis of coronary heart disease (CHD) in symptomatic patients with advanced atherosclerosis of the carotid artery was more successful using ultrasound technology than exercise electrocardiography (ECG). METHODS: Within the scope of an occupational screening program using subjects from diverse employment sectors, people were given the opportunity to determine their risk of heart attack. During the study, the total plaque area (TPA), the maximum plaque thickness in the carotid artery and the PROCAM scores of 3,513 healthy men and 2,088 healthy women between the ages of 20 and 65 were determined...
February 2017: Cardiology Research
https://www.readbyqxmd.com/read/28274576/long-term-follow-up-of-probands-with-brugada-syndrome
#13
Carlo de Asmundis, Giacomo Mugnai, Gian-Battista Chierchia, Juan Sieira, Giulio Conte, Moises Rodriguez-Mañero, Gudrun Pappaert, Jens Czapla, Jan Nijs, Mark La Meir, Ruben Casado, Erwin Ströker, Valentina De Regibus, Pedro Brugada
This study analyzes the natural history of a large cohort of probands with Brugada syndrome (BrS) to assess the predictive value of different clinical and electrocardiographic parameters for the development of ventricular fibrillation (VF) or sudden cardiac death (SCD) during a long-term follow-up. Baseline characteristics of 289 consecutive probands (203 men; mean age 45 ± 16 years) with a Brugada type 1 electrocardiogram were analyzed. After a mean follow-up of 10.1 ± 4.6 years, 29 malignant arrhythmias occurred...
February 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28266823/cardiovascular-disease-update-atrial-fibrillation
#14
Johnathan D McDivitt, Craig Barstow
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The prevalence increases with age, especially in the seventh and eighth decades of life. AF also is associated with multiple risk factors and conditions that are managed commonly in family medicine settings, such as hypertension and diabetes. Rhythm control and rate control are primarily equivalent for mortality rate, but patients treated for rhythm control have more hospitalizations; however, rhythm control may be a viable option for select patients...
March 2017: FP Essentials
https://www.readbyqxmd.com/read/28259228/cha2ds2-vasc-score-a-predictor-of-thromboembolic-events-and-mortality-in-patients-with-an-implantable-monitoring-device-without-atrial-fibrillation
#15
Christine Parsons, Salma I Patel, Stephen Cha, Win-Kuang Shen, Santosh Desai, Alanna M Chamberlain, Sushil Allen Luis, Maria I Aguilar, Bart M Demaerschalk, Farouk Mookadam, Fadi Shamoun
OBJECTIVE: To determine if the CHA2DS2-VASc score (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, stroke or transient ischemic attack, vascular disease, age 65-74 years, sex category) predicts thromboembolism and death in patients without atrial fibrillation in a population with implantable cardiac monitoring devices. PATIENTS AND METHODS: A retrospective review utilizing the Rochester Epidemiology Project research infrastructure was conducted to evaluate the CHA2DS2-VASc tool as a predictor of mortality and ischemic stroke, transient ischemic attack, or systemic embolism in patients without atrial fibrillation...
March 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28254555/epidemiology-and-outcomes-of-arterial-ischemic-stroke-in-children-the-canadian-pediatric-ischemic-stroke-registry
#16
Gabrielle A deVeber, Adam Kirton, Frances A Booth, Jerome Y Yager, Elaine C Wirrell, Ellen Wood, Michael Shevell, Ann-Marie Surmava, Patricia McCusker, M Patricia Massicotte, Daune MacGregor, E Athen MacDonald, Brandon Meaney, Simon Levin, Bernard G Lemieux, Lawrence Jardine, Peter Humphreys, Michèle David, Anthony K C Chan, David J Buckley, Bruce H Bjornson
BACKGROUND: Pediatric arterial ischemic stroke remains incompletely understood. Population-based epidemiological data inform clinical trial design but are scant in this condition. We aimed to determine age-specific epidemiological characteristics of arterial ischemic stroke in neonates (birth to 28 days) and older children (29 days to 18 years). METHODS: We conducted a 16-year, prospective, national population-based study, the Canadian Pediatric Ischemic Stroke Registry, across all 16 Canadian acute care children's hospitals...
January 26, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28249831/negotiating-tensions-between-theory-and-design-in-the-development-of-mailings-for-people-recovering-from-acute-coronary-syndrome
#17
Holly O Witteman, Justin Presseau, Emily Nicholas Angl, Iffat Jokhio, J D Schwalm, Jeremy M Grimshaw, Beth Bosiak, Madhu K Natarajan, Noah M Ivers
BACKGROUND: Taking all recommended secondary prevention cardiac medications and fully participating in a formal cardiac rehabilitation program significantly reduces mortality and morbidity in the year following a heart attack. However, many people who have had a heart attack stop taking some or all of their recommended medications prematurely and many do not complete a formal cardiac rehabilitation program. OBJECTIVE: The objective of our study was to develop a user-centered, theory-based, scalable intervention of printed educational materials to encourage and support people who have had a heart attack to use recommended secondary prevention cardiac treatments...
March 1, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28247846/incidence-of-device-detected-atrial-fibrillation-and-long-term-outcomes-in-patients-with-hypertrophic-cardiomyopathy
#18
Hannah G van Velzen, Dominic A M J Theuns, Sing-Chien Yap, Michelle Michels, Arend F L Schinkel
Atrial fibrillation (AF) is a common complication of hypertrophic cardiomyopathy (HC) and associated with adverse clinical outcomes, such as thromboembolisms. Cardiac implantable electronic devices (CIEDs) enable early detection of AF. The aim of this study was to assess the incidence of device-detected AF and the impact on long-term outcomes in patients with HC. The cohort consisted of 132 patients (63% men, mean age 52 ± 16 years) with a diagnosis of HC and a CIED. Follow-up started at the date of CIED implantation to assess the incidence of device-detected AF...
January 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28246237/cardiac-outcomes-after-ischemic-stroke-or-tia-effects-of-pioglitazone-in-patients-with-insulin-resistance-without-diabetes
#19
Lawrence H Young, Catherine M Viscoli, Jeptha P Curtis, Silvio E Inzucchi, Gregory G Schwartz, Anne M Lovejoy, Karen L Furie, Mark J Gorman, Robin A Conwit, J Dawn Abbott, Daniel L Jacoby, Daniel M Kolansky, Steven E Pfau, Frederick S Ling, Walter N Kernan
Background -Insulin resistance is highly prevalent among patients with atherosclerosis and is associated with an increased risk for myocardial infarction (MI) and stroke. The Insulin Resistance Intervention after Stroke (IRIS) trial demonstrated that pioglitazone decreased the composite risk for fatal or non-fatal stroke and MI in patients with insulin resistance without diabetes, after a recent ischemic stroke or transient ischemic attack. The type and severity of cardiac events in this population, and the impact of pioglitazone on these events has not been described...
February 28, 2017: Circulation
https://www.readbyqxmd.com/read/28241354/effect-of-fibrinogen-concentrate-on-intraoperative-blood-loss-among-patients-with-intraoperative-bleeding-during-high-risk-cardiac-surgery-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Süleyman Bilecen, Joris A H de Groot, Cor J Kalkman, Alexander J Spanjersberg, George J Brandon Bravo Bruinsma, Karel G M Moons, Arno P Nierich
Importance: Fibrinogen concentrate might partly restore coagulation defects and reduce intraoperative bleeding. Objective: To determine whether fibrinogen concentrate infusion dosed to achieve a plasma fibrinogen level of 2.5 g/L in high-risk cardiac surgery patients with intraoperative bleeding reduces intraoperative blood loss. Design, Setting, and Participants: A randomized, placebo-controlled, double-blind clinical trial conducted in Isala Zwolle, the Netherlands (February 2011-January 2015), involving patients undergoing elective, high-risk cardiac surgery (ie, combined coronary artery bypass graft [CABG] surgery and valve repair or replacement surgery, the replacement of multiple valves, aortic root reconstruction, or reconstruction of the ascending aorta or aortic arch) with intraoperative bleeding (blood volume between 60 and 250 mL suctioned from the thoracic cavity in a period of 5 minutes) were randomized to receive either fibrinogen concentrate or placebo...
February 21, 2017: JAMA: the Journal of the American Medical Association
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