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Tiliroside

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https://www.readbyqxmd.com/read/29604376/identification-and-characterization-of-potential-bioactive-compounds-from-the-leaves-of-leucosidea-sericea
#1
Srinivasa C Pendota, Adeyemi O Aremu, Lenka Poštová Slavětínská, Lucie Rárová, Jiří Grúz, Karel Doležal, Johannes Van Staden
ETHNOPHARMACOLOGICAL RELEVANCE: Leucosidea sericea is a southern African tree used for treating different diseases including microbial infections and inflammatory-related conditions. AIM OF THE STUDY: To isolate and identify the chemicals in Leucosidea sericea which possibly account for the diverse therapeutic effects of the species. MATERIALS AND METHODS: Leaf material was extracted using 20% methanol and subsequently partitioned with different solvents (hexane, dichloromethane, ethyl acetate and butanol)...
March 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29508282/activation-of-nrf2-pathway-contributes-to-neuroprotection-by-the-dietary-flavonoid-tiliroside
#2
Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Olumayokun A Olajide
Hyperactivated microglia plays a key role in regulating neuroinflammatory responses which cause damage to neurons. In recent years, substantial attention has been paid in identifying new strategies to abrogate neuroinflammation. Tiliroside, a natural dietary glycosidic flavonoid, is known to inhibit neuroinflammation. This study was aimed at investigating the molecular mechanisms involved in the inhibition of neuroinflammation and neurotoxicity by tiliroside. The effects of tiliroside on Nrf2 and SIRT1 activities in BV2 microglia and HT22 hippocampal neurons were investigated using immunoblotting and DNA binding assays...
March 5, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29290397/antibacterial-potential-of-the-cistus-incanus-l-phenolics-as-studied-with-use-of-thin-layer-chromatography-combined-with-direct-bioautography-and-in-situ-hydrolysis
#3
Ágnes M Móricz, Dariusz Szeremeta, Magdalena Knaś, Ewa Długosz, Péter G Ott, Teresa Kowalska, Mieczysław Sajewicz
The main aim of this study was to detect and identify antibacterial components of fraction I derived from eleven commercial C. incanus herbal teas. Fraction I obtained by a well-established phytochemical protocol of a multi-step extraction was expected to contain flavonoid aglycons alone. Antibacterial profile of fraction I was demonstrated by means of thin-layer chromatography - direct bioautography (TLC-DB) using a Gram positive B. subtilis and a Gram negative A. fischeri strain. Six chromatographic zones of fraction I exhibited a well pronounced antibacterial potential...
January 26, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29236499/mutual-interaction-of-phenolic-compounds-and-microbiota-metabolism-of-complex-phenolic-apigenin-c-and-kaempferol-o-derivatives-by-human-fecal-samples
#4
Maren Vollmer, Selma Esders, Freda M Farquharson, Susanne Neugart, Sylvia Duncan, Monika Schreiner, Petra Louis, Ronald Maul, Sascha Rohn
Human colonic bacteria have an important impact on the biotransformation of flavonoid glycosides and their conversion can result in the formation of bioactive compounds. However, information about the microbial conversion of complex glycosylated flavonoids and the impact on the gut microbiota are still limited. In this study, the ability of different donors' human intestinal microbiota to convert selected flavonoid O- and C-glycosides was evaluated by performing in vitro fermentations. The results show that all flavonoid glycosides were metabolized via their aglycones yielding smaller substances...
December 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28976589/simultaneous-determination-and-pharmacokinetic-study-of-three-flavonoid-glycosides-in-rat-plasma-by-lc-ms-ms-after-oral-administration-of-rubus-chingii-hu-extract
#5
Tao Zan, Li Piao, Yuntao Wei, Yue Gu, Baohua Liu, Daqing Jiang
A simple and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of isoquercitrin, kaempferol-3-O-rutinoside and tiliroside in rat plasma. Plasma samples were deproteinized with methanol and separated on a Hypersil Gold C18 column (2.1 × 50 mm, i.d., 3.0 μm) using gradient elution with the mobile phase of water and methanol at a flow rate of 0.4 mL/min. Mass spectrometric detection was performed with negative ion electrospray ionization in selected reaction monitoring mode...
March 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28920463/evaluation-of-genotoxicity-and-subchronic-toxicity-of-standardized-rose-hip-extract
#6
A Nagatomo, M Oguri, N Nishida, M Ogawa, A Ichikawa, Y Tanaka-Azuma
Rose hip is the fruit of the rose plant, which is widely used in food, cosmetics and as a traditional medicine. Therefore, rose hip is considered safe and has a sufficient history of consumption as food. However, few studies have reported on the safety of rose hip extracts in toxicological analyses. Thus, to evaluate the safety of rosehip polyphenol MJ (RHPMJ), an aqueous ethanol extract standardized with the trans-tiliroside content, we performed genotoxicity and 90-day repeated oral dose toxicity studies in compliance with the Organisation for Economic Co-operation and Development-Good Laboratory Practice...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28887920/isolation-of-natural-products-with-anti-ageing-activity-from-the-fruits-of-platanus-orientalis
#7
Sofia Chatzigeorgiou, Quoc Dang Thai, Job Tchoumtchoua, Konstantinos Tallas, Eleni N Tsakiri, Issidora Papassideri, Maria Halabalaki, Alexios-Leandros Skaltsounis, Ioannis P Trougakos
BACKGROUND: Ageing is defined as the time-dependent decline of functional capacity and stress resistance resulting in increased morbidity and mortality. HYPOTHESIS/PURPOSE: Reportedly, these effects can be delayed by mild genetic or pharmacological activation of the main modules of the proteostasis network. STUDY DESIGN-METHODS: By employing advanced phytochemical methods we isolated natural products from the fruits of Platanus orientalis and studied (via a bio-guided approach) their effects in Drosophila flies, as well as in normal human fibroblasts...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28749448/pharmacokinetic-study-of-biotransformation-products-from-an-anxiolytic-fraction-of-tilia-americana
#8
Virgilio Alfonso Juárez Ramírez, María Isabel Jiménez-Beltrán, Alejandro Zamilpa, Maribel Herrera-Ruiz, Rodolfo Abarca-Vargas, Galia Lombardo-Earl, Jaime Tortoriello, Enrique Jiménez-Ferrer
An anxiolytic fraction of Tilia americana standardized in tiliroside, rutin, quercitrin, quercetin glucoside, and kaempferol was obtained. After oral administration of the fraction, the above-mentioned flavonoids were not detected in plasma over 24 h. However, meta and para hydroxyphenylacetic acid and dihydroxyphenylacetic acid (m-HPAA, p-HPAA and DOPAC) were monitored. These are the biotransformation compounds of the aglycones of kaempferol and quercetin; these aglycones are products of the other flavonoids present in the anxiolytic fraction...
July 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28704976/role-of-the-p-coumaroyl-moiety-in-the-antioxidant-and-cytoprotective-effects-of-flavonoid-glycosides-comparison-of-astragalin-and-tiliroside
#9
COMPARATIVE STUDY
Xican Li, Yage Tian, Tingting Wang, Qiaoqi Lin, Xiaoyi Feng, Qian Jiang, Yamei Liu, Dongfeng Chen
The aim of this study was to explore the role of p -coumaroyl in the antioxidant and cytoprotective effects of flavonoid glycosides. The antioxidant effects of astragalin and tiliroside were compared using ferric ion reducing antioxidant power, DPPH• scavenging, ABTS•⁺ scavenging, •O₂- scavenging, and Fe2+ -chelating assays. The results of these assays revealed that astragalin and tiliroside both exhibited dose-dependent activities; however, tiliroside exhibited lower IC50 values than astragalin. In the Fe2+ -chelating assay, tiliroside gave a larger shoulder-peak at 510 nm than astragalin, and was also found to be darker in color...
July 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28539736/antiprotozoal-activities-of-tiliroside-and-other-compounds-from-sphaeralcea-angustifolia-cav-g-don
#10
Fernando Calzada, Jose Correa Basurto, Elizabeth Barbosa, Claudia Velázquez, Normand García Hernández, R M Ordoñez Razo, David Mendez Luna, Lilian Yepez Mulia
BACKGROUND: Sphaeralcea angustifolia (Malvaceae) is extensively used in Mexican traditional medicine for the treatment of gastrointestinal disorders such as diarrhea and dysentery. OBJECTIVE: The current study was to validate the traditional use of S. angustifolia for the treatment of diarrhea and dysentery on biological grounds using in vitro antiprotozoal activity and computational experiments. MATERIALS AND METHODS: The ethanol extract, subsequent fractions, flavonoids, phenolic acids, and a sterol were evaluated on Entamoeba histolytica and Giardia lamblia trophozoites...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539715/antiprotozoal-antibacterial-and-antidiarrheal-properties-from-the-flowers-of-chiranthodendron-pentadactylon-and-isolated-flavonoids
#11
Fernando Calzada, Teresa Juárez, Normand García-Hernández, Miguel Valdes, Oscar Ávila, Lilian Yepez Mulia, Claudia Velázquez
BACKGROUND: Chiranthodendron pentadactylon Larreat. (Sterculiaceae) is a Mexican plant used in traditional medicine for the treatment of heart disease symptoms and infectious diarrhea. OBJECTIVE: To evaluate in vitro antiprotozoal and antibacterial activities and in vivo antidiarrheal activity from the flowers of C. pentadactylon using the extract, fractions, and major isolated flavonoids. MATERIALS AND METHODS: Bioassay-guided fractionation of the methanol extract of C...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28453223/molecularly-imprinted-polymers-for-the-selective-extraction-of-tiliroside-from-the-flowers-of-edgeworthia-gardneri-wall-meisn
#12
Die Gao, Qi-Feng Fu, Lu-Jun Wang, Dan-Dan Wang, Kai-Lian Zhang, Feng-Qing Yang, Zhi-Ning Xia
Nano-sized molecularly imprinted polymers for tiliroside were successfully prepared by a precipitation polymerization method. Acrylamide, ethylene glycol dimethacrylate, azobisisobutyronitrile, and acetonitrile/dimethyl sulfoxide were used as functional monomer, cross-linker, initiator, and porogen, respectively. The structural features and morphological characterization of tiliroside-imprinted polymers were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy, respectively...
June 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28385048/a-new-alkaloid-and-flavonoids-isolated-from-solanum-cernuum-leaves-by-high-performance-countercurrent-chromatography
#13
Amaro Chaves Ramos, Rodrigo Rodrigues de Oliveira
Solanum cernuum is a medicinal plant widely distributed in south-east regions of Brazil and popularly used to treat several disorders. Despite their utilisation as a medicine, few studies on its chemical composition are reported. An efficient separation method for the ethyl acetate fraction was developed by high-performance countercurrent chromatography using n-butanol/chloroform/methanol/water (3:7:3:4, v/v/v/v) as the solvent system, affording five compounds (1-5) in one-step separation. A new cyclic guanidine alkaloid named cernidine (5) was obtained, besides four glycosylated flavonoids: afzelin (1), astragalin (2), kaempferol 3-O-α[apiofuranosyl-(1 → 2)]-α-rhamnopyranoside (3) and kaempferol 3-O-α[apiofuranosyl-(1→2)]-β-galactopyranoside (4)...
April 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28294523/flavonoids-from-potentilla-parvifolia-fisch-and-their-neuroprotective-effects-in-human-neuroblastoma-sh-sy5y-cells-in-vitro
#14
Zhenzhen Yuan, Guangxiang Luan, Zhenhua Wang, Xueyan Hao, Ji Li, Yourui Suo, Gang Li, Honglun Wang
Potentilla parvifolia Fisch. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH-SY5Y cells were differentiated with all trans-retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model...
June 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28208718/on-line-screening-isolation-and-identification-of-antioxidant-compounds-of-helianthemum-ruficomum
#15
Yasmine Chemam, Samir Benayache, Eric Marchioni, Minjie Zhao, Paul Mosset, Fadila Benayache
Many Helianthemum species (Cistaceae) are recognized for their various medicinal virtues. Helianthemum ruficomum is an endemic species to the septentrional Sahara on which no report is available so far. The purpose of this work was to investigate the chemical composition and the radical scavenging capacity of this species and its isolated components. Collected from Mougheul (south-west of Algeria), the aerial parts were macerated with 80% EtOH/H₂O, after evaporation, the remaining extract was diluted with H₂O and extracted with petroleum ether, chloroform, ethyl acetate and n-butanol...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28118725/synergistic-antibacterial-effects-of-herbal-extracts-and-antibiotics-on-methicillin-resistant-staphylococcus-aureus-a-computational-and-experimental-study
#16
Chiu-Fai Kuok, Sai-On Hoi, Chi-Fai Hoi, Chi-Hong Chan, Io-Hong Fong, Cheong-Kei Ngok, Li-Rong Meng, Pedro Fong
Antibiotic resistance has become a serious global concern, and the discovery of antimicrobial herbal constituents may provide valuable solutions to overcome the problem. In this study, the effects of therapies combining antibiotics and four medicinal herbs on methicillin-resistant Staphylococcus aureus (MRSA) were investigated. Specifically, the synergistic effects of Magnolia officinalis, Verbena officinalis, Momordica charantia, and Daphne genkwa in combination with oxacillin or gentamicin against methicillin-resistant (ATCC43300) and methicillin-susceptible (ATCC25923) S...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28088385/flavonoid-derivative-fla-cn-inhibited-adipocyte-differentiation-via-activating-ampk-and-up-regulating-microrna-27-in-3t3-l1-cells
#17
Chun-Chun Gan, Tian-Wen Ni, Yang Yu, Nan Qin, Ying Chen, Mei-Na Jin, Hong-Quan Duan
Fla-CN (3-O-[(E)-4-(4-cyanophenyl)-2-oxobut-3-en-1-yl] kaempferol) is a semi-synthesized flavonoid derivative of tiliroside which exhibited anti-diabetic effect in vivo. Our previous study revealed the role of Fla-CN in anti-obesity and anti-diabetes in vivo, but the underlying mechanism remained to be addressed. The present study aimed to investigate the mechanism of anti-adipogenesis in vitro. Fla-CN markedly inhibited intracellular lipid accumulation in a dose-dependent manner, and the inhibitory effect was mainly limited to the early stage of adipocyte differentiation in vitro...
February 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27951697/experimental-modeling-of-flavonoid-biomembrane-interactions
#18
Didem Sanver, Brent S Murray, Amin Sadeghpour, Michael Rappolt, Andrew L Nelson
Nonspecific interactions of flavonoids with lipids can alter the membrane's features (e.g., thickness and fluctuations) as well as influence their therapeutic potentials. However, relatively little is known about the details of how flavonoids interact with lipid components. Structure-dependent interactions of a variety of flavonoids with phospholipid monolayers on a mercury (Hg) film electrode were established by rapid cyclic voltammetry (RCV). The data revealed that flavonoids adopting a planar configuration altered the membrane properties more significantly than nonplanar flavonoids...
December 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27690380/flavonoids-from-litsea-japonica-inhibit-ages-formation-and-rat-lense-aldose-reductase-in-vitro-and-vessel-dilation-in-zebrafish
#19
Ik-Soo Lee, Yu Jin Kim, Seung-Hyun Jung, Joo-Hwan Kim, Jin Sook Kim
In our ongoing efforts to identify effective naturally sourced agents for the treating of diabetic complications, two new (1 and 2) and 11 known phenolic compounds (3-13) were isolated from an 80 % ethanol extract of Litsea japonica leaves. The structures of the new compounds were established by spectroscopic and chemical studies. These isolates (1-13) were subjected to an in vitro bioassay evaluating their inhibitory activity on advanced glycation end products formation and rat lens aldose reductase activity...
February 2017: Planta Medica
https://www.readbyqxmd.com/read/27396196/chemical-constituents-from-the-roots-stems-and-leaves-of-diplomorpha-sikokiana
#20
Hari Prasad Devkota, Khem Raj Joshi, Takashi Watanabe, Shoji Yahara
Four diarylpentanoids (1-4), two phenylpropanoids (5-6), three biflavonoids (7-9), two lignans (10-11) and a coumarin (12) were isolated from the roots of Diploniorpha sikokiana (Franchet & Savatier) Honda (Family: Thymelaeaceae). Similarly, two phenylpropanoids (5-6), five biflavonoids (7-9, 13, 14), three lignans (11, 15, 16), a flavonoid (17) and two coumarins (12, 18) were isolated from the stems, and five flavonoids (17, 19-22) from the leaves. Among them, 1,5-diphenyl-l-pentanone (1), 1,5-diphenyl-2-penten-l-one (2), 3(S)-hydroxy-1,5-diphenylpentane (3), stelleranol (8), (-)-syringaresinol (10), (-)-pinoresinol 4,4'-di-O-β-D-glucopyranoside (11), apiosylskimmin (12), syringaresinol 4-O-β-D-glucopyranoside (16), quercetin 3-O-α-L-rhamnopyranoside (19), kaempferol 3-0-α-L-rhamnopyranoside (20) and tiliroside (21) were isolated for the first time from D...
April 2016: Natural Product Communications
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