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Tiliroside

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https://www.readbyqxmd.com/read/27690380/flavonoids-from-litsea-japonica-inhibit-ages-formation-and-rat-lense-aldose-reductase-in-vitro-and-vessel-dilation-in-zebrafish
#1
Ik-Soo Lee, Yu Jin Kim, Seung-Hyun Jung, Joo-Hwan Kim, Jin Sook Kim
In our ongoing efforts to identify effective naturally sourced agents for the treating of diabetic complications, two new (1 and 2) and 11 known phenolic compounds (3-13) were isolated from an 80 % ethanol extract of Litsea japonica leaves. The structures of the new compounds were established by spectroscopic and chemical studies. These isolates (1-13) were subjected to an in vitro bioassay evaluating their inhibitory activity on advanced glycation end products formation and rat lens aldose reductase activity...
September 30, 2016: Planta Medica
https://www.readbyqxmd.com/read/27396196/chemical-constituents-from-the-roots-stems-and-leaves-of-diplomorpha-sikokiana
#2
Hari Prasad Devkota, Khem Raj Joshi, Takashi Watanabe, Shoji Yahara
Four diarylpentanoids (1-4), two phenylpropanoids (5-6), three biflavonoids (7-9), two lignans (10-11) and a coumarin (12) were isolated from the roots of Diploniorpha sikokiana (Franchet & Savatier) Honda (Family: Thymelaeaceae). Similarly, two phenylpropanoids (5-6), five biflavonoids (7-9, 13, 14), three lignans (11, 15, 16), a flavonoid (17) and two coumarins (12, 18) were isolated from the stems, and five flavonoids (17, 19-22) from the leaves. Among them, 1,5-diphenyl-l-pentanone (1), 1,5-diphenyl-2-penten-l-one (2), 3(S)-hydroxy-1,5-diphenylpentane (3), stelleranol (8), (-)-syringaresinol (10), (-)-pinoresinol 4,4'-di-O-β-D-glucopyranoside (11), apiosylskimmin (12), syringaresinol 4-O-β-D-glucopyranoside (16), quercetin 3-O-α-L-rhamnopyranoside (19), kaempferol 3-0-α-L-rhamnopyranoside (20) and tiliroside (21) were isolated for the first time from D...
April 2016: Natural Product Communications
https://www.readbyqxmd.com/read/27350007/the-flower-of-edgeworthia-gardneri-wall-meisn-suppresses-adipogenesis-through-modulation-of-the-ampk-pathway-in-3t3-l1-adipocytes
#3
Die Gao, Yong-Lan Zhang, Feng-Qing Yang, Fan Li, Qi-Hui Zhang, Zhi-Ning Xia
ETHNOPHARMACOLOGICAL RELEVANCE: The flower of Edgeworthia gardneri (Wall.) Meisn., locally named "Lvluohua, ", has been widely used as Tibetan folk medicine for the treatment of metabolic diseases for a long time. AIM OF THIS STUDY: To evaluate the anti-adipogenesis effect of ethyl acetate extract of the flower of E. gardneri (EEG extract) in 3T3-L1 adipocytes. MATERIALS AND METHODS: Obesity-related parameters such as lipid accumulation and TG content were determined by Oil red O staining and enzymatic kit, respectively...
September 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27347085/tiliroside-the-major-component-of-agrimonia-pilosa-ledeb-ethanol-extract-inhibits-mapk-jnk-p38-mediated-inflammation-in-lipopolysaccharide-activated-raw-264-7-macrophages
#4
Xin Jin, Shiqing Song, Jing Wang, Qingzhen Zhang, Feng Qiu, Feng Zhao
In the present study, the in vivo anti-inflammatory activity of Agrimonia pilosa Ledeb (AP) ethanol extract was confirmed in experimental animal models, including xylene-induced ear edema in mice and carrageenan-induced paw edema in rats. Tiliroside, the major component of AP extract, was isolated and purified by high-performance liquid chromatography. The anti-inflammatory mechanism of tiliroside was then examined using lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells. An MTT assay was used to determine cytotoxicity and a Griess assay was used to determine nitric oxide (NO) production...
July 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27322221/high-resolution-%C3%AE-glucosidase-inhibition-profiling-combined-with-hplc-hrms-spe-nmr-for-identification-of-antidiabetic-compounds-in-eremanthus-crotonoides-asteraceae
#5
Eder Lana E Silva, Jonathas Felipe Revoredo Lobo, Joachim Møllesøe Vinther, Ricardo Moreira Borges, Dan Staerk
α-Glucosidase inhibitors decrease the cleavage- and absorption rate of monosaccharides from complex dietary carbohydrates, and represent therefore an important class of drugs for management of type 2 diabetes. In this study, a defatted ethyl acetate extract of Eremanthus crotonoides leaves with an inhibitory concentration (IC50) of 34.5 μg/mL towards α-glucosidase was investigated by high-resolution α-glucosidase inhibition profiling combined with HPLC-HRMS-SPE-NMR. This led to identification of six α-glucosidase inhibitors, namely quercetin (16), trans-tiliroside (17), luteolin (19), quercetin-3-methyl ether (20), 3,5-di-O-caffeoylquinic acid n-butyl ester (26) and 4,5-di-O-caffeoylquinic acid n-butyl ester (29)...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26790297/-flavonoids-from-whole-plants-of-lagopsis-supina
#6
Jing Zhang, Dao-ran Pang, Zheng Huang, Hui-xia Huo, Yue-ting Li, Jiao Zheng, Qian Zhang, Yun-fang Zhao, Peng-fei Tu, Jun Li
The flavonoids were investigated from the whole plants of Lagopsis supina. The compounds were isolated and purified by various column chromatography, and their structures were identified by physiochemical properties and spectroscopic data. Two flavones were isolated from the CH2Cl2 layer of Lagopsis supina extract and identified as genkwanin (1) and 5-hydroxy-7,4'-dimethoxyflavone (2), respectively. Ten flavonoid glycosides were isolated from the water layer of Lagopsis supina and elucidated as kaempferol-3-O-6" (3-hydroxy-3-methylglutaryl) -β-D-glucoside (3), quercetin-3-O-6"-(3-hydroxy-3-methylglutaryl) -β-D-glucoside (4), quercetin-3-O-β-D-glucoside(5), kaempferol-3-Of3-D-glucoside ( 6), isorhamnetin-3-O-/-D-glycopyranoside (7), apigenin-7-O-6-D-glucoside (8), luteolin-7-O-β-D-glucoside (9), chrysoeriol-7-O-β-D-glucoside (10), rutin (11 ), and kaempferol-3-β-(6"-p-coumaroyl) -β-D-glucoside (tiliroside, 12)...
August 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26787614/total-phenolic-content-and-antioxidant-activity-of-some-malvaceae-family-species
#7
Adriana Maria Fernandes de Oliveira, Lilian Sousa Pinheiro, Charlane Kelly Souto Pereira, Wemerson Neves Matias, Roosevelt Albuquerque Gomes, Otemberg Souza Chaves, Maria de Fátima Vanderlei de Souza, Reinaldo Nóbrega de Almeida, Temilce Simões de Assis
The antioxidant activity of four species of the Malvaceae family (Sidastrum micranthum (A. St.-Hil.) Fryxell, Wissadula periplocifolia (L.) C. Presl, Sida rhombifolia (L.) E. H. L and Herissantia crispa L. (Brizicky)) were studied using the total phenolic content, DPPH radical scavenging activity and Trolox equivalent antioxidant capacity (TEAC) assays. The antioxidant activity of the crude extract, phases and two isolated flavonoids, kaempferol 3,7-di-O-α-l-rhamnopyranoside (lespedin) and kaempferol 3-O-β-d-(6''-E-p-coumaroil) glucopyranoside (tiliroside) was determined...
2012: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/26655407/cytotoxicity-of-compounds-from-xylopia-aethiopica-towards-multi-factorial-drug-resistant-cancer-cells
#8
Victor Kuete, Louis P Sandjo, Armelle T Mbaveng, Maen Zeino, Thomas Efferth
INTRODUCTION: Multidrug resistance (MDR) in cancer represent a major hurdle in chemotherapy. Previously, the methanol extract of the medicinal spice Xylopia aethiopica displayed considerable cytotoxicity against multidrug resistant (MDR) cancer cell lines. METHODS: The present study was designed to assess the cytotoxicity of compounds, 16α-hydroxy-ent-kauran-19-oic acid (2), 3,4',5-trihydroxy-6″,6″-dimethylpyrano[2,3-g]flavone (3), isotetrandrine (5) and trans-tiliroside (6) derived from the methanol crude extract of Xylopia aethiopica against 9 drug-sensitive and -resistant cancer cell lines...
December 15, 2015: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26610436/new-sulphated-flavonoids-from-wissadula-periplocifolia-l-c-presl-malvaceae
#9
Yanna C F Teles, Carolina Campolina Rebello Horta, Maria de Fátima Agra, Weam Siheri, Marie Boyd, John O Igoli, Alexander I Gray, Maria de Fátima Vanderlei de Souza
Wissadula periplocifolia (L.) C. Presl (Malvaceae) is commonly used in Brazil to treat bee stings and as an antiseptic. The antioxidant properties of its extracts have been previously demonstrated, thus justifying a phytochemical investigation for its bioactive phenolic constituents. This has yielded five new sulphated flavonoids: 8-O-sulphate isoscutellarein (yannin) (1a); 4'-O-methyl-7-O-sulphate isoscutellarein (beltraonin) (1b); 7-O-sulphate acacetin (wissadulin) (2a); 4'-O-methyl-8-O-sulphate isoscutellarein (caicoine) (2b) and 3'-O-methyl-8-O-sulphate hypolaetin (pedroin) (3b) along with the known flavonoids 7,4'-di-O-methyl-8-O-sulphate isoscutellarein (4), acacetin, apigenin, isoscutellarein, 4´-O-methyl isoscutellarein, 7,4'-di-O-methylisoscutellarein, astragalin and tiliroside...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26598088/anti-obesity-and-anti-diabetic-effects-of-flavonoid-derivative-fla-cn-via-microrna-in-high-fat-diet-induced-obesity-mice
#10
Nan Qin, Ying Chen, Mei-Na Jin, Chang Zhang, Wei Qiao, Xiao-Long Yue, Hong-Quan Duan, Wen-Yan Niu
3-O-[(E)-4-(4-cyanophenyl)-2-oxobut-3-en-1-yl]kaempferol (Fla-CN), a semi-synthesized flavonoid derivative of tiliroside, reduces whole-body adiposity, ameliorates metabolic lipid disorder, improves insulin sensitivity and benefits other disorders characterized by insulin resistance in high fat diet induced obesity mice. The improvement of insulin sensitivity and the reduction of weight gain are correlated with the changes of leptin and adiponectin levels. As a result, Fla-CN treatment could increase the expressions of pAMPK and miR-27 in the liver and adipose tissues...
January 20, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26569200/new-sulphated-flavonoids-from-wissadula-periplocifolia-l-c-presl-malvaceae
#11
Yanna C F Teles, Carolina Campolina Rebello Horta, Maria de Fátima Agra, Weam Siheri, Marie Boyd, John O Igoli, Alexander I Gray, Maria de Fátima Vanderlei de Souza
Wissadula periplocifolia (L.) C. Presl (Malvaceae) is commonly used in Brazil to treat bee stings and as an antiseptic. The antioxidant properties of its extracts have been previously demonstrated, thus justifying a phytochemical investigation for its bioactive phenolic constituents. This has yielded five new sulphated flavonoids: 8-O-sulphate isoscutellarein (yannin) (1a); 4'-O-methyl-7-O-sulphate isoscutellarein (beltraonin) (1b); 7-O-sulphate acacetin (wissadulin) (2a); 4'-O-methyl-8-O-sulphate isoscutellarein (caicoine) (2b) and 3'-O-methyl-8-O-sulphate hypolaetin (pedroin) (3b) along with the known flavonoids 7,4'-di-O-methyl-8-O-sulphate isoscutellarein (4), acacetin, apigenin, isoscutellarein, 4'-O-methyl isoscutellarein, 7,4'-di-O-methylisoscutellarein, astragalin and tiliroside...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26511291/flavonoid-derivative-exerts-an-antidiabetic-effect-via-ampk-activation-in-diet-induced-obesity-mice
#12
Ying Chen, Chang Zhang, Mei-Na Jin, Nan Qin, Wei Qiao, Xiao-Long Yue, Hong-Quan Duan, Wen-Yan Niu
In our previous study, a derivative of tiliroside, 3-O-[(E)-4-(4-ethoxyphenyl)-2-oxobut-3-en-1-yl]kaempferol (Fla-OEt) significantly enhanced glucose consumption in insulin resistant HepG2 cells. This article deals with the antihyperglycemic and antihyperlipidemic effects of Fla-OEt in diet-induced obesity (DIO) mice. Daily administration of Fla-OEt significantly decreased oral glucose tolerance test, intraperitoneal insulin tolerance test and serum lipids. Hyperinsulinemic-euglycemic clamp and the ratio of high-density-lipoprotein/low-density-lipoprotein with Fla-OEt treatment were increased comparing with high-fat diet (HFD) group, so lipid metabolism was improved...
September 2016: Natural Product Research
https://www.readbyqxmd.com/read/26434278/antithrombotic-activity-of-fractions-and-components-obtained-from-raspberry-leaves-rubus-chingii
#13
Na Han, Yuhong Gu, Chun Ye, Yan Cao, Zhihui Liu, Jun Yin
The 70% ethanol fraction from an aqueous extract of raspberry leaves was shown to be the most antithrombotic fraction in in vitro and in vivo tests. The total flavonoids and phenolics in this fraction were 0.286g/g and 0.518g/g by colorimetry. Six compounds, including salicylic acid, kaempferol, quercetin, tiliroside, quercetin 3-O-β-d-glucopyranoside and kaempferol 3-O-β-d-glucopyranoside, were isolated from the active fraction. Among them, kaempferol, quercetin and tiliroside obviously delayed plasma recalcification time (PRT) in blood...
May 1, 2012: Food Chemistry
https://www.readbyqxmd.com/read/26053738/bioactive-comparison-of-main-components-from-unripe-fruits-of-rubus-chingii-hu-and-identification-of-the-effective-component
#14
Tian-Tian Zhang, Li Yang, Jian-Guo Jiang
Dried and unripe fruit of Rubus chingii Hu, known as "Fu-pen-zi" in Chinese, has been used as a food and tonic in China for a long time. In order to analyze its effective ingredients, polysaccharides, flavonoids, saponins and alkaloids were extracted from the unripe fruits and their contents were determined. The in vitro antioxidant, anticomplementary and anticancer activities against human lung adenocarcinoma A549 cells of the four major constituents were investigated. Results showed that total flavonoids exhibited an obvious antioxidant activity, which was very close to ascorbic acid...
July 2015: Food & Function
https://www.readbyqxmd.com/read/25761590/transport-of-trans-tiliroside-kaempferol-3-%C3%AE-d-6-p-coumaroyl-glucopyranoside-and-related-flavonoids-across-caco-2-cells-as-a-model-of-absorption-and-metabolism-in-the-small-intestine
#15
Zijun Luo, Michael R A Morgan, Andrea J Day
1. Absorption and metabolism of tiliroside (kaempferol 3-β-D-(6"-p-coumaroyl)-glucopyranoside) and its related compounds kaempferol, kaempferol-3-glucoside and p-coumaric acid were investigated in the small intestinal Caco-2 cell model. Apparent permeation (Papp) was determined as 0.62 × 10(-6) cm/s, 3.1 × 10(-6) cm/s, 0 and 22.8 × 10(-6) cm/s, respectively. 2. Mechanistic study showed that the transportation of tiliroside, kaempferol-3-glucoside and p-coumaric acid in Caco-2 model were transporter(s) involved, while transportation of kaempferol was solely by passive diffusion mechanism...
2015: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/25656001/interactions-of-a-standardized-flavonoid-fraction-from-tilia-americana-with-serotoninergic-drugs-in-elevated-plus-maze
#16
M C Noguerón-Merino, E Jiménez-Ferrer, R Román-Ramos, A Zamilpa, J Tortoriello, M Herrera-Ruiz
ETHNOPHARMACOLOGICAL RELEVANCE: Tilia americana var. mexicana (Schltdl) Hardin (Tiliaceae) aerial parts (bracts and flowers) are used in the traditional Mexican medicine to treat nervous disorders, as sedative and to treat insomnia. A fraction of this species called FC1 (organic fraction from this plant) was proposed, described as anxiolytic and characterized by the presence of flavonoids. In the present work, this fraction was standardized, and its interaction with different serotonergic drugs was tested...
April 22, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/25649464/new-c%C3%A2-%C3%A2-gibberellin-diterpene-from-the-leaves-of-schefflera-sessiliflora-de-p-v
#17
Tan Phat Nguyen, Thi Thao Vy Tran, Dinh Tri Mai, Tien Dung Le, Nhat Minh Phan, Trong Dat Bui
From the leaves of Schefflera sessiliflora De P. V., one new C20-gibberellin diterpene 2β,12β-dihydroxygibberellin (12β-hydroxy-GA110 or 2β-hydroxy-GA112) (1), together with three known compounds, trans-tiliroside (2), kaempferol 3-O-β-D-glucuronopyranoside (3), 5-p-trans-coumaroylquinic acid (4), was isolated for the first time from the genus Schefflera by various chromatography methods. Their structures were elucidated by IR, UV, HR-ESI-MS, NMR 1D and 2D experiments and comparison with previous reported data...
2015: Natural Product Research
https://www.readbyqxmd.com/read/25298684/the-pavonia-xanthogloea-ekman-malvaceae-phenolic-compounds-quantification-anti-oxidant-and-cytotoxic-effect-on-human-lymphocytes-cells
#18
Clarice Pinheiro Mostardeiro, Marco Aurélio Mostardeiro, Ademir Farias Morel, Raul Moreira Oliveira, Alencar Kolinski Machado, Pauline Ledur, Francine Carla Cadoná, Ubiratan Flores da Silva, Ivana Beatrice Mânica da Cruz
INTRODUCTION: Pavonia xanthogloea is traditionally used as an antimicrobial and anti-tumour medicine in Southern Brazilian region. However, investigations about this species are still incipient. HYPOTHESIS TESTED: The study postulated that P. xanthologea specie present some phenolic compound and present some biological properties as anti-oxidant and cytoprotective effect against oxidative stress. MATERIALS AND METHODS: The content of eight phenolic molecules in the crude ethanolic extract of the aerial part of P...
August 2014: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/25293350/pine-pinus-morrisonicola-hayata-needle-extracts-sensitize-gbm8901-human-glioblastoma-cells-to-temozolomide-by-downregulating-autophagy-and-o-6-methylguanine-dna-methyltransferase-expression
#19
Chia-Leng Liao, Chien-Min Chen, Yan-Zin Chang, Guang-Yaw Liu, Hui-Chih Hung, Tung-Ying Hsieh, Chih-Li Lin
Pine needle extracts of Pinus morrisonicola (Hayata) are commonly used as a functional health beverage. However, it remains unclear what the mechanism is underlying the antitumor activity of pine needle extract. The aims of present study were to investigate the anti-glioblastoma effects of pine needle extracts as well as its bioactive compounds. From three different solvent extracts of pine needles, the water extract displayed the strongest cytotoxicity effects on GBM8901 glioblastoma cells. The isolated compounds were identified as pinocembrin, chrysin, and tiliroside...
October 29, 2014: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25152356/tiliroside-a-dietary-glycosidic-flavonoid-inhibits-traf-6-nf-%C3%AE%C2%BAb-p38-mediated-neuroinflammation-in-activated-bv2-microglia
#20
Ravikanth Velagapudi, Mutallib Aderogba, Olumayokun A Olajide
BACKGROUND: Tiliroside is a dietary glycosidic flavonoid which has shown in vivo anti-inflammatory activity. This study is aimed at evaluating the effect of tiliroside on neuroinflammation in BV2 microglia, and to identify its molecular targets of anti-neuroinflammatory action. METHODS: BV2 cells were stimulated with LPS+IFNγ in the presence or absence of tiliroside. TNFα, IL-6, nitrite and PGE2 production was determined with ELISA, Griess assay and enzyme immunoassay, respectively...
December 2014: Biochimica et Biophysica Acta
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