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https://www.readbyqxmd.com/read/29671223/laparoscopic-paraaortic-surgical-staging-in-locally-advanced-cervical-cancer-a-single-center-experience
#1
D Vázquez-Vicente, B Fernández Del Bas, J García Villayzán, H A Di Fiore, J Luna Tirado, V Casado Echarren, J García-Foncillas, J Plaza Arranz, L Chiva
BACKGROUND: One aim of this study was to assess the efficacy and safety of laparoscopic paraaortic lymphadenectomy for paraaortic lymph node staging in locally advanced cervical carcinoma. The second aim was to identify prognostic factors in the evolution of this disease and to evaluate how the results of the surgery modify the oncological treatment of patients. MATERIALS AND METHODS: We analyzed 59 patients diagnosed with locally advanced cervical cancer International Federation of Gynecology and Obstetrics stage IB2-IVA who underwent laparoscopic paraaortic lymphadenectomy at our hospital between 2009 and 2015...
April 18, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29644480/correction-to-microleakage-in-class-v-composite-and-compomer-restorations-following-exposure-to-a-colutory-prescribed-for-the-treatment-of-xerostomy
#2
Ascensión Vicente, Antonio J Ortiz, Pablo L Parra, José L Calvo-Guirado, Fernando Chiva
In the original publication of the article, one of the author names was published incorrectly as José L. Calvo. The correct name is José L. Calvo-Guirado.
April 11, 2018: Odontology
https://www.readbyqxmd.com/read/29552019/c-reactive-protein-in-atherothrombosis-and-angiogenesis
#3
REVIEW
Lina Badimon, Esther Peña, Gemma Arderiu, Teresa Padró, Mark Slevin, Gemma Vilahur, Gemma Chiva-Blanch
C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions. This review is focused on discussing the role of CRP in cardiovascular disease, including recent advances on the implication of CRP and its forms specifically on the pathogenesis of atherothrombosis and angiogenesis. Besides its role in the humoral innate immune response, CRP contributes to cardiovascular disease progression by recognizing and binding multiple intrinsic ligands...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29488009/innovating-undergraduate-pathology-education-through-public-engagement
#4
Navin Mukundu Nagesh, Bogdan Chiva Giurca, Suzy Lishman
The trends in modern undergraduate medical education focus on a patient-centred approach through problem-based learning over the traditional modular curriculum. Integrating pathology into this style of learning has resulted in the dilution of core scientific principles which may have contributed to reduced understanding and interest in the subject. We aim to innovate pathology education by utilising National Pathology Week which is organised by the Royal College of Pathologists to develop the public engagement model which empowers students to learn pathology by teaching the public...
February 27, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29428861/the-effects-of-sediment-used-in-beach-nourishment-study-case-el-portet-de-moraira-beach
#5
L Chiva, J I Pagán, I López, A J Tenza-Abril, L Aragonés, I Sánchez
Actions taken to prevent or reduce coastal erosion often do not have the desired effect, leading to major problems instead of solving the original one. This research focuses on why a nourished beach- with borrowed sand and 0.05% of particles <0.063 mm- causes the presence of suspended particles that are observed by beach users as turbidity. This means that the colour of the water was not its characteristic blue, even with calm wave conditions. This research involved a shoreline evolution analysis and a sedimentological study of the sand from 1977 to 2017...
July 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29427781/retroperitoneal-laparoscopic-para-aortic-lymphadenectomy-in-para-aortic-staging-of-locally-advanced-cervical-cancer
#6
Daniel Vázquez-Vicente, Bárbara Fernández Del Bas, José García Villayzán, Javier Plaza Arranz, Luis Chiva
STUDY OBJECTIVE: To review/learn a surgical technique not very well-known by gynecologic oncologists. DESIGN: Level of evidence III. SETTING: A review of a surgical technique with emphasis on the para-aortic sentinel lymph nodes using indocyanine green. INTERVENTION: The film features the following steps to perform the procedure: 1. Creating a retroperitoneal window. 2. What to do if the peritoneum is torn. 3. Finding the psoas muscle, right ureter, and common iliac artery...
February 7, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29331859/development-of-a-method-to-determine-axitinib-lapatinib-and-afatinib-in-plasma-by-micellar-liquid-chromatography-and-validation-by-the-european-medicines-agency-guidelines
#7
Jaume Albiol-Chiva, Josep Esteve-Romero, Juan Peris-Vicente
A method based on micellar liquid chromatography to quantify the tyrosine kinase inhibitors axitinib, lapatinib and afatinib in plasma is reported. The sample pretreatment was a simple 1/5-dilution in a pure micellar solution, filtration and direct injection, without requiring extraction or purification steps. The three drugs were resolved from the matrix in 17min, using an aqueous solution of 0.07M sodium dodecyl sulfate - 6.0% 1-pentanol, buffered at pH7 with 0.01M phosphate salt as mobile phase, running under isocratic mode at 1mL/min through a C18 column...
February 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29324744/qcloud-a-cloud-based-quality-control-system-for-mass-spectrometry-based-proteomics-laboratories
#8
Cristina Chiva, Roger Olivella, Eva Borràs, Guadalupe Espadas, Olga Pastor, Amanda Solé, Eduard Sabidó
The increasing number of biomedical and translational applications in mass spectrometry-based proteomics poses new analytical challenges and raises the need for automated quality control systems. Despite previous efforts to set standard file formats, data processing workflows and key evaluation parameters for quality control, automated quality control systems are not yet widespread among proteomics laboratories, which limits the acquisition of high-quality results, inter-laboratory comparisons and the assessment of variability of instrumental platforms...
2018: PloS One
https://www.readbyqxmd.com/read/29321574/impact-of-climate-change-and-human-activity-on-soil-landscapes-over-the-past-12-300-years
#9
Leo Rothacker, Anthony Dosseto, Alexander Francke, Allan R Chivas, Nathalie Vigier, Anna M Kotarba-Morley, Davide Menozzi
Soils are key to ecosystems and human societies, and their critical importance requires a better understanding of how they evolve through time. However, identifying the role of natural climate change versus human activity (e.g. agriculture) on soil evolution is difficult. Here we show that for most of the past 12,300 years soil erosion and development were impacted differently by natural climate variability, as recorded by sediments deposited in Lake Dojran (Macedonia/Greece): short-lived ( < 1,000 years) climatic shifts had no effect on soil development but impacted soil erosion...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/28945143/cost-effectiveness-analysis-of-secukinumab-for-the-treatment-of-active-psoriatic-arthritis-a-canadian-perspective
#10
Ron Goeree, Sima Chiva-Razavi, Praveen Gunda, Christopher N Graham, LaStella Miles, Efthalia Nikoglou, Steffen M Jugl, Dafna D Gladman
OBJECTIVE: The study evaluates the cost-effectiveness of secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin (IL)-17A, vs currently licensed biologic treatments in patients with active psoriatic arthritis (PsA) from a Canadian healthcare system perspective. METHODS: A decision analytic semi-Markov model evaluated the cost-effectiveness of secukinumab 150 mg and 300 mg compared to subcutaneous biologics adalimumab, certolizumab pegol, etanercept, golimumab, and ustekinumab, and intravenous biologics infliximab and infliximab biosimilar in biologic-naive and biologic-experienced patients over a lifetime horizon...
February 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/28930554/diet-microparticles-and-atherothrombosis
#11
Lina Badimon, Rosa Suades, Javier Crespo, Teresa Padro, Gemma Chiva-Blanch
Cardiovascular disease is the main cause of death worldwide, and is principally caused by atherosclerosis, with subsequent thrombus formation, eventually provoking an acute myocardial infarction or a stroke. The formation and progression of the atherosclerotic plaques responds to multiple factors including certain diets. Intensive research has elucidated the role of diet in cardiovascular disease and has led to public health policies focusing on educating the population on the role of nutrition in cardiovascular health...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28894509/effects-of-polyphenol-intake-on-metabolic-syndrome-current-evidences-from-human-trials
#12
REVIEW
Gemma Chiva-Blanch, Lina Badimon
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors which severely increases the risk of type II diabetes and cardiovascular disease. Several epidemiological studies have observed a negative association between polyphenol intake and MetS rates. Nevertheless, there are relatively small numbers of interventional studies evidencing this association. This review is focused on human interventional trials with polyphenols as polyphenol-rich foods and dietary patterns rich in polyphenols in patients with MetS...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28861742/current-situation-in-gynecological-oncology-training-in-spain-where-we-are-and-where-we-want-to-go
#13
P Padilla-Iserte, L Minig, I Zapardiel, L Chiva, R Laky, J de Santiago
BACKGROUND: It is important to know what a young gynecologic oncologist perceives as a need to achieve a good training in gynecologic oncology. OBJECTIVE: This study aims to evaluate the level of training in gynecologic oncology in Spain. METHODS: A Web-based anonymous questionnaire was sent via e-mail to Spanish trainees listed in European Network of Young Gynecological Oncology (ENYGO). The survey was developed in four sections: (1) general training in gynecologic oncology, (2) distribution of current clinical activity, (3) surgical training, and (4) perspective future gynecologic oncology...
August 31, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28697926/health-literacy-and-health-outcomes-in-very-old-patients-with-heart-failure
#14
Rocío León-González, Esther García-Esquinas, Emilio Paredes-Galán, Ana Isabel Ferrero-Martínez, José Luis González-Guerrero, Mercedes Hornillos-Calvo, Rocío Menéndez-Colino, Ivett Torres-Torres, María Concepción Galán, Marta Torrente-Carballido, Mayte Olcoz-Chiva, Carlos Rodríguez-Pascual, Fernando Rodríguez-Artalejo
INTRODUCTION AND OBJECTIVES: Health literacy (HL) has been associated with lower mortality in heart failure (HF). However, the results of previous studies may not be generalizable because the research was conducted in relatively young and highly-educated patients in United States settings. This study assessed the association of HL with disease knowledge, self-care, and all-cause mortality among very old patients, with a very low educational level. METHODS: This prospective study was performed in 556 patients (mean age, 85 years), with high comorbidity, admitted for HF to the geriatric acute-care unit of 6 hospitals in Spain...
March 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28692440/cefepime-associated-with-phenytoin-induced-stevens-johnson-syndrome
#15
José Marco-Del Río, Esther Domingo-Chiva, Pablo Cuesta-Montero, Ana Valladolid-Walsh, Eva María García-Martínez
We describe a recent case of Stevens-Johnson Syndrome. A 49-year-old man was admitted to the Intensive Care Unit of an Anaesthesia and Resuscitation Department because of a Fournier gangrene that derived in a sepsis, ventilator-associated pneumonia, and renal failure. He was under treatment with cefepime and suffered a generalized status epilepticus, so started treatment with phenytoin. The next day he developed a "maculous cutaneous eruption in trunk and lower limbs" compatible with a Stevens-Johnson Syndrome...
July 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28608394/a-discovery-driven-approach-to-elucidate-urinary-metabolome-changes-after-a-regular-and-moderate-consumption-of-beer-and-nonalcoholic-beer-in-subjects-at-high-cardiovascular-risk
#16
Paola Quifer-Rada, Gemma Chiva-Blanch, Olga Jáuregui, Ramon Estruch, Rosa M Lamuela-Raventós
SCOPE: The aim of this work was to study the urinary metabolomics changes of participants that consumed beer, nonalcoholic beer (na-beer), and gin. METHODS AND RESULTS: Thirty-three males at high cardiovascular risk between 55 and 75 years old participated in an open, randomized, crossover, controlled trial with three nutritional interventions consisting of beer, na-beer, and gin for 4 wk. Diet and physical activity was monitored throughout the study and compliance was assessed by measurement of urinary isoxanthohumol...
June 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28594844/prediction-of-adjuvant-chemotherapy-response-in-triple-negative-breast-cancer-with-discovery-and-targeted-proteomics
#17
Angelo Gámez-Pozo, Lucía Trilla-Fuertes, Guillermo Prado-Vázquez, Cristina Chiva, Rocío López-Vacas, Paolo Nanni, Julia Berges-Soria, Jonas Grossmann, Mariana Díaz-Almirón, Eva Ciruelos, Eduard Sabidó, Enrique Espinosa, Juan Ángel Fresno Vara
BACKGROUND: Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancers and usually requires the administration of adjuvant chemotherapy after surgery but even with this treatment many patients still suffer from a relapse. The main objective of this study was to identify proteomics-based biomarkers that predict the response to standard adjuvant chemotherapy, so that patients at are not going to benefit from it can be offered therapeutic alternatives. METHODS: We analyzed the proteome of a retrospective series of formalin-fixed, paraffin-embedded TNBC tissue applying high-throughput label-free quantitative proteomics...
2017: PloS One
https://www.readbyqxmd.com/read/28559046/ceftazidime-induced-thrombocytopenia
#18
E Domingo-Chiva, M Díaz-Rangel, J Á Monsalve-Naharro, P Cuesta-Montero, J V Catalá-Ripoll, E M García-Martínez
Ceftazidime is an antibiotic belonging to the group of third generation cephalosporins, frequently used in clinical practice for its broad antibacterial spectrum. A case report is presented on a 78-year-old man who entered the intensive care unit due to respiratory failure secondary to nosocomial pneumonia in the postoperative period of a laparoscopic hepatic bisegmentectomy for a hepatocarcinoma. It required invasive mechanical ventilation and was treated with ceftazidime, developing a progressive decrease in platelet count after the onset of this drug and after re-exposure to it, not coinciding with the introduction of other drugs...
May 27, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28520456/development-and-validation-of-a-micellar-liquid-chromatographic-method-to-determine-three-antitumorals-in-plasma
#19
Josep Esteve Romero, Jaume Albiol Chiva, Juan Peris-Vicente, Enrique Ochoa-Aranda
AIM: A micellar liquid chromatographic method to determine several anticancer drugs (pazopanib, dabrafenib and regorafenib) in plasma was developed and validated by the guidelines of the EMA. EXPERIMENTAL: Plasma samples were directly injected, after a 1/5-dilution in a micellar solution. The drugs were resolved in <18 min using a C18 column. The mobile phase was an aqueous solution of 0.12 M SDS - 2% 1-pentanol, buffered at pH 7. The detection was performed by absorbance at 260 nm...
May 2017: Bioanalysis
https://www.readbyqxmd.com/read/28489035/development-of-conductivity-sensors-for-multi-phase-flow-local-measurements-at-the-polytechnic-university-of-valencia-upv-and-university-jaume-i-of-castellon-uji
#20
REVIEW
José Luis Muñoz-Cobo, Sergio Chiva, Santos Méndez, Guillem Monrós, Alberto Escrivá, José Luis Cuadros
This paper describes all the procedures and methods currently used at UPV (Universitat Politécnica de Valencia) and UJI (University Jaume I) for the development and use of sensors for multi-phase flow analysis in vertical pipes. This paper also describes the methods that we use to obtain the values of the two-phase flow magnitudes from the sensor signals and the validation and cross-verification methods developed to check the consistency of the results obtained for these magnitudes with the sensors. First, we provide information about the procedures used to build the multi-sensor conductivity probes and some of the tests performed with different materials to avoid sensor degradation issues...
May 10, 2017: Sensors
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