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Carlos Rodríguez-Pascual, Emilio Paredes-Galán, Ana Isabel Ferrero-Martínez, José Antonio Baz-Alonso, Darío Durán-Muñoz, Eva González-Babarro, Marcelo Sanmartín, Teresa Parajes, Ivett Torres-Torres, Miguel Piñón-Esteban, Francisco Calvo-Iglesias, Maria Teresa Olcoz-Chiva, Fernando Rodríguez-Artalejo
BACKGROUND: The role of frailty as a prognostic factor in non-selected patients with symptomatic severe aortic stenosis (SAS) is still uncertain. This study aims to examine the association between the frailty syndrome and mortality among very old patients with symptomatic SAS, and to assess whether the association varies with the type of SAS treatment. METHODS AND RESULTS: Prospective study of 606 patients aged ≥75years with symptomatic SAS, recruited from February 2010 to January 2015, who were followed up through June 2015...
September 14, 2016: International Journal of Cardiology
Denis Querleu, François Planchamp, Luis Chiva, Christina Fotopoulou, Desmond Barton, David Cibula, Giovanni Aletti, Silvestro Carinelli, Carien Creutzberg, Ben Davidson, Philip Harter, Lene Lundvall, Christian Marth, Philippe Morice, Arash Rafii, Isabelle Ray-Coquard, Andrea Rockall, Cristiana Sessa, Ate van der Zee, Ignace Vergote, Andreas du Bois
OBJECTIVES: The surgical management of advanced ovarian cancer involves complex surgery. Implementation of a quality management program has a major impact on survival. The goal of this work was to develop a list of quality indicators (QIs) for advanced ovarian cancer surgery that can be used to audit and improve the clinical practice. This task has been carried out under the auspices of the European Society of Gynaecologic Oncology (ESGO). METHODS: Quality indicators were based on scientific evidence and/or expert consensus...
September 2016: International Journal of Gynecological Cancer
Alba Mota, Eva Colás, Pablo García-Sanz, Irene Campoy, Alejandro Rojo-Sebastián, Sonia Gatius, Ángel García, Luis Chiva, Sonsoles Alonso, Antonio Gil-Moreno, Xavier González-Tallada, Berta Díaz-Feijoo, August Vidal, Patrycja Ziober-Malinowska, Marcin Bobiński, Rafael López-López, Miguel Abal, Jaume Reventós, Xavier Matias-Guiu, Gema Moreno-Bueno
Endometrial cancer is the most common cancer of the female genital tract in developed countries. Although the majority of endometrial cancers are diagnosed at early stages and the 5-year overall survival is around 80%, early detection of these tumors is crucial to improve the survival of patients given that the advanced tumors are associated with a poor outcome. Furthermore, correct assessment of the pre-clinical diagnosis is decisive to guide the surgical treatment and management of the patient. In this sense, the potential of targeted genetic sequencing of uterine aspirates has been assessed as a pre-operative tool to obtain reliable information regarding the mutational profile of a given tumor, even in samples that are not histologically classifiable...
September 2, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Allen P Nutman, Vickie C Bennett, Clark R L Friend, Martin J Van Kranendonk, Allan R Chivas
Biological activity is a major factor in Earth's chemical cycles, including facilitating CO2 sequestration and providing climate feedbacks. Thus a key question in Earth's evolution is when did life arise and impact hydrosphere-atmosphere-lithosphere chemical cycles? Until now, evidence for the oldest life on Earth focused on debated stable isotopic signatures of 3,800-3,700 million year (Myr)-old metamorphosed sedimentary rocks and minerals from the Isua supracrustal belt (ISB), southwest Greenland. Here we report evidence for ancient life from a newly exposed outcrop of 3,700-Myr-old metacarbonate rocks in the ISB that contain 1-4-cm-high stromatolites-macroscopically layered structures produced by microbial communities...
August 31, 2016: Nature
I Martínez-Navarro, O Chiva-Bartoll, B Hernando, E Collado, V Porcar, C Hernando
PURPOSE: The present study aimed to explore whether Blood Pressure (BP) and Heart Rate Variability (HRV) responsiveness to orthostatism, jointly with Executive Function (EF) performance, were diminished following an ultraendurance mountain race. Besides, we wanted to assess whether hydration status was related to either performance or the abovementioned alterations. METHODS: Fifty recreational ultraendurance athletes participating in the Penyagolosa Trails CSP115 race (118 km and a total positive elevation of 5439 m) were evaluated before and after the competition...
August 18, 2016: Journal of Strength and Conditioning Research
André Luís Morais Ruela, Eduardo Costa de Figueiredo, Magali Benjamim de Araújo, Flávia Chiva Carvalho, Gislaine Ribeiro Pereira
Donepezil is a drug administered for Alzheimer's disease treatment, and it is a potential template molecule for imprinted microparticles. The precipitation polymerization technique allows the synthesis of spherical imprinted microparticles, and the intermolecular interactions among drug and molecularly imprinted polymers (MIPs) play a promising role for delineating drug delivery systems. Once that donepezil is a poorly-water soluble compound, lipid based-formulations (LBFs) may enhance its oral administration...
October 10, 2016: European Journal of Pharmaceutical Sciences
Beyhan Ataseven, Luis M Chiva, Philipp Harter, Antonio Gonzalez-Martin, Andreas du Bois
Epithelial ovarian, fallopian tube and peritoneal cancer (EOC) is the seventh most common cancer diagnosis among women worldwide and shows the highest mortality rate of all gynecologic tumors. Different histological and anatomic spread patterns as well as multiple gene-expression based studies have demonstrated that EOC is indeed a heterogeneous disease. The prognostic factors that best predict the survival in this disease include: age, performance status and patient's comorbidities at the time of diagnosis; tumor biology, histological type, amount of residual tumor after surgery and finally tumor stage as surrogate for pre-operative tumor burden and growth pattern...
September 2016: Gynecologic Oncology
Eva Liñeiro, Cristina Chiva, Jesús M Cantoral, Eduard Sabidó, Francisco Javier Fernández-Acero
Botrytis cinerea is a model fungus for the study of phytopathogenicity that exhibits a wide arsenal of tools to infect plant tissues. Most of these factors are related to signal transduction cascades, in which membrane proteins play a key role as a bridge between environment and intracellular molecular processes. This work describes the first description of the membranome of Botrytis under different pathogenicity conditions induced by different plant-based elicitors: glucose and tomato cell wall (TCW). A discovery proteomics analysis of membrane proteins was carried out by mass spectrometry...
September 2016: Proteomics
P Cuesta-Montero, E Domingo-Chiva, S Plata-Paniagua, J A Monsalve-Naharro, B Montalban-Moreno, J M Jimenez-Vizuete, A Valladolid-Walsh, R Peyro-García
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
J A Monsalve-Naharro, P Cuesta-Montero, E Domingo-Chiva, S Plata-Paniagua, A López-Pérez, F Martinez-Lopez, J M Jimenez-Vizuete
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Ramon Estruch, Miguel Angel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, Gemma Chiva-Blanch, Miquel Fiol, Enrique Gómez-Gracia, Fernando Arós, José Lapetra, Lluis Serra-Majem, Xavier Pintó, Pilar Buil-Cosiales, José V Sorlí, Miguel A Muñoz, Josep Basora-Gallisá, Rosa María Lamuela-Raventós, Mercè Serra-Mir, Emilio Ros
BACKGROUND: Because of the high density of fat, high-fat diets are perceived as likely to lead to increased bodyweight, hence health-care providers are reluctant to recommend them to overweight or obese individuals. We assessed the long-term effects of ad libitum, high-fat, high-vegetable-fat Mediterranean diets on bodyweight and waist circumference in older people at risk of cardiovascular disease, most of whom were overweight or obese. METHODS: PREDIMED was a 5 year parallel-group, multicentre, randomised, controlled clinical trial done in primary care centres affiliated to 11 hospitals in Spain...
August 2016: Lancet Diabetes & Endocrinology
Josep Esteve-Romero, Jaume Albiol-Chiva, Juan Peris-Vicente
Therapeutic drug monitoring is a common practice in clinical studies. It requires the quantification of drugs in biological fluids. Micellar liquid chromatography (MLC), a well-established branch of Reverse Phase-High Performance Liquid Chromatography (RP-HPLC), has been proven by many researchers as a useful tool for the analysis of these matrices. This review presents several analytical methods, taken from the literature, devoted to the determination of several monitorable drugs in serum and urine by micellar liquid chromatography...
July 5, 2016: Analytica Chimica Acta
G de Gaetano, S Costanzo, A Di Castelnuovo, L Badimon, D Bejko, A Alkerwi, G Chiva-Blanch, R Estruch, C La Vecchia, S Panico, G Pounis, F Sofi, S Stranges, M Trevisan, F Ursini, C Cerletti, M B Donati, L Iacoviello
A large evidence-based review on the effects of a moderate consumption of beer on human health has been conducted by an international panel of experts who reached a full consensus on the present document. Low-moderate (up to 1 drink per day in women, up to 2 in men), non-bingeing beer consumption, reduces the risk of cardiovascular disease. This effect is similar to that of wine, at comparable alcohol amounts. Epidemiological studies suggest that moderate consumption of either beer or wine may confer greater cardiovascular protection than spirits...
June 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Arnau Sebé-Pedrós, Cecilia Ballaré, Helena Parra-Acero, Cristina Chiva, Juan J Tena, Eduard Sabidó, José Luis Gómez-Skarmeta, Luciano Di Croce, Iñaki Ruiz-Trillo
The unicellular ancestor of animals had a complex repertoire of genes linked to multicellular processes. This suggests that changes in the regulatory genome, rather than in gene innovation, were key to the origin of animals. Here, we carry out multiple functional genomic assays in Capsaspora owczarzaki, the unicellular relative of animals with the largest known gene repertoire for transcriptional regulation. We show that changing chromatin states, differential lincRNA expression, and dynamic cis-regulatory sites are associated with life cycle transitions in Capsaspora...
May 19, 2016: Cell
Gemma Chiva-Blanch, Rosa Suades, Teresa Padró, Gemma Vilahur, Esther Peña, Juan Ybarra, Jose M Pou, Lina Badimon
INTRODUCTION AND OBJECTIVES: Diabetes mellitus is associated with an enhanced risk for cardiovascular disease and its prevalence is increasing. Diabetes induces metabolic stress on blood and vascular cells, promoting platelet activation and vascular dysfunction. The level of vascular cell activation can be measured by the number and phenotype of microparticles found in the circulation. The aim of this study was to investigate the effect of a platelet-inhibitory dose of aspirin on the number and type of microparticles shed to the circulation...
July 2016: Revista Española de Cardiología
Gemma Chiva-Blanch, Javier Crespo, Rosa Suades, Gemma Arderiu, Teresa Padro, Gemma Vilahur, Judith Cubedo, Dolores Corella, Jordi Salas-Salvadó, Fernando Arós, Miguel-Angel Martínez-González, Emilio Ros, Montse Fitó, Ramon Estruch, Lina Badimon
Circulating microparticles (cMPs) are small phospholipid-rich microvesicles shed by activated cells that play a pivotal role in cell signalling related to the pathogenesis of atherothrombosis. We aimed to investigate the prognostic value of cMPs released from different vascular cells for cardiovascular event (CVE) presentation in asymptomatic patients at high cardiovascular risk factors under nutritional and pharmacologic treatment. This is a nested case-control study of 50 patients from the five-year follow-up prospective PREDIMED trial enrolled in the nuts arm of the Mediterranean diet (MedDiet-nuts)...
July 4, 2016: Thrombosis and Haemostasis
Luis M Chiva, Teresa Castellanos, Sonsoles Alonso, Antonio Gonzalez-Martin
OBJECTIVE: The objective of this review was to try to determine by searching in the literature what is the survival in patients with advanced ovarian cancer after a primary debulking with minimal macroscopic residual disease (MMRD; 0.1-10 mm). Additionally, this review aimed to explore the survival in patients with residual disease from 0.1 to 0.5 cm. METHODS: A retrospective search was accomplished in the PubMed database looking for all English-language articles published between January 1, 2007 and December 31, 2014, under the following search strategy: "ovarian cancer and cytoreduction" or "ovarian cancer and phase III trial"...
June 2016: International Journal of Gynecological Cancer
Eva Liñeiro, Cristina Chiva, Jesús M Cantoral, Eduard Sabido, Francisco Javier Fernández-Acero
UNLABELLED: The phytopathogen Botrytis cinerea is a ubiquitous fungus with a high capacity to adapt its metabolism to different hosts and environmental conditions in order to deploy a variety of virulence and pathogenicity factors and develop a successful plant infection. Here we report the first comparative phosphoproteomic study of B. cinerea, aimed to analyze the phosphoprotein composition of the fungus and its changes under different phenotypical conditions induced by two different carbon sources as plant based elicitors: glucose and deproteinized tomato cell wall (TCW)...
April 29, 2016: Journal of Proteomics
Palmira Valderas-Martinez, Gemma Chiva-Blanch, Rosa Casas, Sara Arranz, Miriam Martínez-Huélamo, Mireia Urpi-Sarda, Xavier Torrado, Dolores Corella, Rosa M Lamuela-Raventós, Ramon Estruch
Epidemiological studies have observed a negative association between tomato intake and the incidence of cardiovascular disease. As tomato sauces are usually cooked with the addition of oil, some studies have pointed out that both processes may increase the bioavailability of the bioactive compounds. However, the effect of consumption of raw tomatoes and tomato sauces on inflammation biomarkers and adhesion molecules related to atherosclerosis remains unknown. The aim of this study was to test the postprandial effects of a single dose of raw tomatoes (RT), tomato sauce (TS) and tomato sauce with refined olive oil (TSOO) on cardiovascular disease risk factors...
March 2016: Nutrients
Marcello Deraco, Shigeki Kusamura, Dario Baratti
•We raised some methodological concerns and made some comments on the systematic review by Chiva and colleague.•To state that Cytoreduction & HIPEC is not beneficial in front line and platinum sensitive recurrence is highly disputable.•Anyway, the combined treatment should be offered in the context of clinical trial; randomized data are urgently needed.
January 2016: Gynecologic Oncology Reports
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