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https://www.readbyqxmd.com/read/28945143/cost-effectiveness-analysis-of-secukinumab-for-the-treatment-of-active-psoriatic-arthritis-a-canadian-perspective
#1
Ron Goeree, Sima Chiva-Razavi, Praveen Gunda, Christopher N Graham, LaStella Miles, Efthalia Nikoglou, Steffen M Jugl, Dafna Gladman
OBJECTIVE: The study evaluates the cost-effectiveness of secukinumab, a fully human monoclonal antibody that selectively neutralizes interleukin (IL)-17A, versus currently licensed biologic treatments in patients with active psoriatic arthritis (PsA) from a Canadian healthcare system perspective. METHODS: A decision analytic semi-Markov model evaluated the cost-effectiveness of secukinumab 150mg and 300mg compared to subcutaneous biologics adalimumab, certolizumab pegol, etanercept, golimumab, and ustekinumab and intravenous biologics infliximab and infliximab biosimilar in biologic-naive and biologic-experienced patients over a lifetime horizon...
September 25, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28930554/diet-microparticles-and-atherothrombosis
#2
Lina Badimon, Rosa Suades, Javier Crespo, Teresa Padro, Gemma Chiva-Blanch
Cardiovascular disease is the main cause of death worldwide, and is principally caused by atherosclerosis, with subsequent thrombus formation, eventually provoking an acute myocardial infarction or a stroke. The formation and progression of the atherosclerotic plaques responds to multiple factors including certain diets. Intensive research has elucidated the role of diet in cardiovascular disease and has led to public health policies focusing on educating the population on the role of nutrition in cardiovascular health...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28894509/effects-of-polyphenol-intake-on-metabolic-syndrome-current-evidences-from-human-trials
#3
REVIEW
Gemma Chiva-Blanch, Lina Badimon
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors which severely increases the risk of type II diabetes and cardiovascular disease. Several epidemiological studies have observed a negative association between polyphenol intake and MetS rates. Nevertheless, there are relatively small numbers of interventional studies evidencing this association. This review is focused on human interventional trials with polyphenols as polyphenol-rich foods and dietary patterns rich in polyphenols in patients with MetS...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28861742/current-situation-in-gynecological-oncology-training-in-spain-where-we-are-and-where-we-want-to-go
#4
P Padilla-Iserte, L Minig, I Zapardiel, L Chiva, R Laky, J de Santiago
BACKGROUND: It is important to know what a young gynecologic oncologist perceives as a need to achieve a good training in gynecologic oncology. OBJECTIVE: This study aims to evaluate the level of training in gynecologic oncology in Spain. METHODS: A Web-based anonymous questionnaire was sent via e-mail to Spanish trainees listed in European Network of Young Gynecological Oncology (ENYGO). The survey was developed in four sections: (1) general training in gynecologic oncology, (2) distribution of current clinical activity, (3) surgical training, and (4) perspective future gynecologic oncology...
August 31, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28697926/health-literacy-and-health-outcomes-in-very-old-patients-with-heart-failure
#5
Rocío León-González, Esther García-Esquinas, Emilio Paredes-Galán, Ana Isabel Ferrero-Martínez, José Luis González-Guerrero, Mercedes Hornillos-Calvo, Rocío Menéndez-Colino, Ivett Torres-Torres, María Concepción Galán, Marta Torrente-Carballido, Mayte Olcoz-Chiva, Carlos Rodríguez-Pascual, Fernando Rodríguez-Artalejo
INTRODUCTION AND OBJECTIVES: Health literacy (HL) has been associated with lower mortality in heart failure (HF). However, the results of previous studies may not be generalizable because the research was conducted in relatively young and highly-educated patients in United States settings. This study assessed the association of HL with disease knowledge, self-care, and all-cause mortality among very old patients, with a very low educational level. METHODS: This prospective study was performed in 556 patients (mean age, 85 years), with high comorbidity, admitted for HF to the geriatric acute-care unit of 6 hospitals in Spain...
July 8, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28692440/cefepime-associated-with-phenytoin-induced-stevens-johnson-syndrome
#6
José Marco-Del Río, Esther Domingo-Chiva, Pablo Cuesta-Montero, Ana Valladolid-Walsh, Eva María García-Martínez
We describe a recent case of Stevens-Johnson Syndrome. A 49-year-old man was admitted to the Intensive Care Unit of an Anaesthesia and Resuscitation Department because of a Fournier gangrene that derived in a sepsis, ventilator-associated pneumonia, and renal failure. He was under treatment with cefepime and suffered a generalized status epilepticus, so started treatment with phenytoin. The next day he developed a "maculous cutaneous eruption in trunk and lower limbs" compatible with a Stevens-Johnson Syndrome...
July 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28608394/a-discovery-driven-approach-to-elucidate-urinary-metabolome-changes-after-a-regular-and-moderate-consumption-of-beer-and-nonalcoholic-beer-in-subjects-at-high-cardiovascular-risk
#7
Paola Quifer-Rada, Gemma Chiva-Blanch, Olga Jáuregui, Ramon Estruch, Rosa M Lamuela-Raventós
SCOPE: The aim of this work was to study the urinary metabolomics changes of participants that consumed beer, nonalcoholic beer (na-beer), and gin. METHODS AND RESULTS: Thirty-three males at high cardiovascular risk between 55 and 75 years old participated in an open, randomized, crossover, controlled trial with three nutritional interventions consisting of beer, na-beer, and gin for 4 wk. Diet and physical activity was monitored throughout the study and compliance was assessed by measurement of urinary isoxanthohumol...
June 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28594844/prediction-of-adjuvant-chemotherapy-response-in-triple-negative-breast-cancer-with-discovery-and-targeted-proteomics
#8
Angelo Gámez-Pozo, Lucía Trilla-Fuertes, Guillermo Prado-Vázquez, Cristina Chiva, Rocío López-Vacas, Paolo Nanni, Julia Berges-Soria, Jonas Grossmann, Mariana Díaz-Almirón, Eva Ciruelos, Eduard Sabidó, Enrique Espinosa, Juan Ángel Fresno Vara
BACKGROUND: Triple-negative breast cancer (TNBC) accounts for 15-20% of all breast cancers and usually requires the administration of adjuvant chemotherapy after surgery but even with this treatment many patients still suffer from a relapse. The main objective of this study was to identify proteomics-based biomarkers that predict the response to standard adjuvant chemotherapy, so that patients at are not going to benefit from it can be offered therapeutic alternatives. METHODS: We analyzed the proteome of a retrospective series of formalin-fixed, paraffin-embedded TNBC tissue applying high-throughput label-free quantitative proteomics...
2017: PloS One
https://www.readbyqxmd.com/read/28559046/ceftazidime-induced-thrombocytopenia
#9
E Domingo-Chiva, M Díaz-Rangel, J Á Monsalve-Naharro, P Cuesta-Montero, J V Catalá-Ripoll, E M García-Martínez
Ceftazidime is an antibiotic belonging to the group of third generation cephalosporins, frequently used in clinical practice for its broad antibacterial spectrum. A case report is presented on a 78-year-old man who entered the intensive care unit due to respiratory failure secondary to nosocomial pneumonia in the postoperative period of a laparoscopic hepatic bisegmentectomy for a hepatocarcinoma. It required invasive mechanical ventilation and was treated with ceftazidime, developing a progressive decrease in platelet count after the onset of this drug and after re-exposure to it, not coinciding with the introduction of other drugs...
May 27, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28520456/development-and-validation-of-a-micellar-liquid-chromatographic-method-to-determine-three-antitumorals-in-plasma
#10
Josep Esteve Romero, Jaume Albiol Chiva, Juan Peris-Vicente, Enrique Ochoa-Aranda
AIM: A micellar liquid chromatographic method to determine several anticancer drugs (pazopanib, dabrafenib and regorafenib) in plasma was developed and validated by the guidelines of the EMA. EXPERIMENTAL: Plasma samples were directly injected, after a 1/5-dilution in a micellar solution. The drugs were resolved in <18 min using a C18 column. The mobile phase was an aqueous solution of 0.12 M SDS - 2% 1-pentanol, buffered at pH 7. The detection was performed by absorbance at 260 nm...
May 18, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28489035/development-of-conductivity-sensors-for-multi-phase-flow-local-measurements-at-the-polytechnic-university-of-valencia-upv-and-university-jaume-i-of-castellon-uji
#11
REVIEW
José Luis Muñoz-Cobo, Sergio Chiva, Santos Méndez, Guillem Monrós, Alberto Escrivá, José Luis Cuadros
This paper describes all the procedures and methods currently used at UPV (Universitat Politécnica de Valencia) and UJI (University Jaume I) for the development and use of sensors for multi-phase flow analysis in vertical pipes. This paper also describes the methods that we use to obtain the values of the two-phase flow magnitudes from the sensor signals and the validation and cross-verification methods developed to check the consistency of the results obtained for these magnitudes with the sensors. First, we provide information about the procedures used to build the multi-sensor conductivity probes and some of the tests performed with different materials to avoid sensor degradation issues...
May 10, 2017: Sensors
https://www.readbyqxmd.com/read/28462707/diet-and-cardiovascular-disease-effects-of-foods-and-nutrients-in-classical-and-emerging-cardiovascular-risk-factors
#12
Lina Badimon, Patricia Chagas, Gemma Chiva-Blanch
Cardiovascular diseases (CVD) are the leading cause of mortality worldwide. Diet comprises a mixture of food compounds that has an influence on human health. The relationship between diet and health is extremely complex and strategies to delay or prevent chronic diseases such as CVD are of utmost interest because chronic diseases and more concretely CVD are still the leading cause of death and disability worldwide. In this mini-review, we aimed to summarize the current knowledge about the principal diet components that potentially influence CVD initiation and progression...
April 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28431588/chiva-a-prospective-study-of-a-vein-sparing-technique-for-the-management-of-varicose-vein-disease
#13
Marta Zmudzinski, Pierre Malo, Christine Hall, Allen Hayashi
BACKGROUND: Varicose vein disease (VVD) affects approximately one third of adults. Cure Conservatrice et Hémodynamique de l'Insuffisance Veineuse en Ambulatoire (CHIVA) is a minimally invasive, vein sparing technique that is emerging as an alternative to ablative techniques for treating VVD. METHODS: This prospective study assessed the rate of recurrence of venous reflux with CHIVA. We evaluated 150 primary procedures with clinical and duplex ultrasound examinations pre and post operatively...
May 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28410284/european-surgical-education-and-training-in-gynecologic-oncology-the-impact-of-an-accredited-fellowship
#14
Luis M Chiva, Jose Mínguez, Denis Querleu, David Cibula, Andreas du Bois
OBJECTIVE: The aim of this study was to understand the current situation of surgical education and training in Europe among members of the European Society of Gynecological Oncology (ESGO) and its impact on the daily surgical practice of those that have completed an accredited fellowship in gynecologic oncology. METHODS: A questionnaire addressing topics of interest in surgical training was designed and sent to ESGO members with surgical experience in gynecologic oncology...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28372157/discrimination-of-whisky-brands-and-counterfeit-identification-by-uv-vis-spectroscopy-and-multivariate-data-analysis
#15
Angélica Rocha Martins, Márcio Talhavini, Maurício Leite Vieira, Jorge Jardim Zacca, Jez Willian Batista Braga
The discrimination of whisky brands and counterfeit identification were performed by UV-Vis spectroscopy combined with partial least squares for discriminant analysis (PLS-DA). In the proposed method all spectra were obtained with no sample preparation. The discrimination models were built with the employment of seven whisky brands: Red Label, Black Label, White Horse, Chivas Regal (12years), Ballantine's Finest, Old Parr and Natu Nobilis. The method was validated with an independent test set of authentic samples belonging to the seven selected brands and another eleven brands not included in the training samples...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28359822/computational-and-experimental-approaches-for-development-of-methotrexate-nanosuspensions-by-bottom-up-nanoprecipitation
#16
Aline Martins Dos Santos, Flávia Chiva Carvalho, Deiver Alessandro Teixeira, David Lima Azevedo, Wander Miguel de Barros, Maria Palmira Daflon Gremião
Development of nanosuspensions offers a promising tool for formulations involving poorly water-soluble drugs. In this study, methotrexate (MTX) nanosuspensions were prepared using a bottom-up process based on acid-base neutralization reactions. Computational studies were performed to determine structural and electronic properties for isolated molecules and molecular clusters in order to evaluate the mechanism of MTX nanoparticle formation. Computational results indicated that the clusters in zwitterionic and cationic states presented larger dimensions and higher energies of interaction between MTX molecules, which favored aggregation...
March 28, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28266123/evaluation-of-different-peptide-fragmentation-types-and-mass-analyzers-in-data-dependent-methods-using-an-orbitrap-fusion-lumos-tribrid-mass-spectrometer
#17
Guadalupe Espadas, Eva Borràs, Cristina Chiva, Eduard Sabidó
One of the major additions in MS technology has been the irruption of the Orbitrap mass analyzer, which has boosted the proteomics analyses of biological complex samples since its introduction. Here, we took advantage of the capabilities of the new Orbitrap Fusion Lumos Tribrid mass spectrometer to assess the performance of different data-dependent acquisition methods for the identification and quantitation of peptides and phosphopeptides in single-shot analysis of human whole cell lysates. Our study explored the capabilities of tri-hibrid mass spectrometers for (phospho-) peptide identification and quantitation using different gradient lengths, sample amounts, and combinations of different peptide fragmentation types and mass analyzers...
May 2017: Proteomics
https://www.readbyqxmd.com/read/28236803/inhaled-nitric-oxide-in-adult-patients-with-acute-respiratory-distress-syndrome
#18
José Ángel Monsalve-Naharro, Esther Domingo-Chiva, Sergio García Castillo, Pablo Cuesta-Montero, José María Jiménez-Vizuete
In some patients, acute respiratory distress syndrome (ARDS) leads to life-threatening refractory hypoxemia developing. Physicians may consider hypoxemic rescue therapies in an attempt to improve oxygenation in these patients while on conventional mechanical ventilation support. Use of inhaled nitric oxide (iNO) in ARDS is one of the most widely-studied pharmacological interventions over the past two decades. Its efficacy was examined in several randomized clinical trials and has undergone meta-analyses...
March 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28215465/the-frailty-syndrome-is-associated-with-adverse-health-outcomes-in-very-old-patients-with-stable-heart-failure-a-prospective-study-in-six-spanish-hospitals
#19
Carlos Rodríguez-Pascual, Emilio Paredes-Galán, Ana-Isabel Ferrero-Martínez, Jose-Luis Gonzalez-Guerrero, Mercedes Hornillos-Calvo, Rocio Menendez-Colino, Ivett Torres-Torres, Arturo Vilches-Moraga, Maria-Concepcion Galán, Francisco Suarez-Garcia, Maria-Teresa Olcoz-Chiva, Fernando Rodríguez-Artalejo
BACKGROUND: Most studies on the association between the frailty syndrome and adverse health outcomes in patients with heart failure (HF) have used non-standard definitions of frailty. This study examined the association of frailty, diagnosed by well-accepted criteria, with mortality, readmission and functional decline in very old ambulatory patients with HF. METHODS: Prospective study with 497 patients in six Spanish hospitals and followed up during one year. Mean (SD) age was 85...
February 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28207887/platelet-monocyte-derived-and-tissue-factor-carrying-circulating-microparticles-are-related-to-acute-myocardial-infarction-severity
#20
Gemma Chiva-Blanch, Kristian Laake, Peder Myhre, Vibeke Bratseth, Harald Arnesen, Svein Solheim, Lina Badimon, Ingebjørg Seljeflot
OBJECTIVE: Circulating microparticles (cMPs) are phospholipid-rich vesicles released from cells when activated or injured, and contribute to the formation of intracoronary thrombi. Tissue factor (TF, CD142) is the main trigger of fibrin formation and TF-carrying cMPs are considered one of the most procoagulant cMPs. Similar types of atherosclerotic lesions may lead to different types of AMI, although the mechanisms behind are unresolved. Therefore, we aimed to investigate the phenotype of cMPs found in plasma of ACS patients and its relation to AMI severity and thrombotic burden...
2017: PloS One
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