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Acute embolism pulmonary

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https://www.readbyqxmd.com/read/29682728/clinical-effects-of-antiplatelet-drugs-and-statins-on-d-dimer-levels
#1
Suzanne Schol-Gelok, Tom van der Hulle, Joseph S Biedermann, Teun van Gelder, Frederikus A Klok, Liselotte M van der Pol, Jorie Versmissen, Menno V Huisman, Marieke J H A Kruip
BACKGROUND: Acute pulmonary embolism may be ruled out by combining non-high clinical probability and a normal D-dimer level. Both antiplatelet drugs and HMG-CoA reductase inhibitors (statins) have been associated with effects on thrombus formation, potentially influencing D-dimer levels in this setting, leading to a higher rate of false-negative tests. Therefore we determined whether D-dimer levels in patients with suspected pulmonary embolism are affected by concomitant use of antiplatelet drugs and/or statins and evaluated if the effect of antiplatelet drugs or statins might affect diagnostic accuracy...
April 22, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29681563/prothrombin-complex-concentrate-and-fatal-thrombotic-adverse-events-a-complication-to-keep-in-mind
#2
Rabih Tabet, Youssef Shammaa, Boutros Karam, Harout Yacoub, James Lafferty
Thromboembolic events such as deep vein thrombosis and pulmonary embolism are well-known complications that can occur after prothrombin complex concentrate therapy. However, acute myocardial infarction is a very rare but potentially life-threatening complication that was exclusively described in patients with bleeding disorders who received chronic and recurrent concentrate infusions. We report the case of a 70 year-old male patient with cholangiocarcinoma who was admitted to our hospital with worsening fatigue and weakness...
April 23, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29680814/spect-v-q-for-the-diagnosis-of-pulmonary-embolism-protocol-for-a-systematic-review-and-meta-analysis-of-diagnostic-accuracy-and-clinical-outcome
#3
Pierre-Yves Le Roux, Philippe Robin, Cécile Tromeur, Alexandra Davis, Helia Robert-Ebadi, Marc Carrier, Francis Couturaud, Grégoire Le Gal, Pierre-Yves Salaun
INTRODUCTION: Single photon emission computed tomography ventilation/perfusion (SPECT V/Q) imaging has many proponents within the nuclear medicine community and has already largely replaced planar V/Q scintigraphy in daily practice for the diagnosis of pulmonary embolism (PE). However, the test is still described in clinical guidelines as an experimental test because of insufficient evidence. METHODS AND ANALYSIS: We will conduct a systematic review and a meta-analysis of diagnostic accuracy and management outcome studies involving patients evaluated with V/Q SPECT for suspected acute PE...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29676061/use-of-fragmented-qrs-in-prognosticating-clinical-deterioration-and-mortality-in-pulmonary-embolism-a-meta-analysis
#4
REVIEW
Amro Qaddoura, Geneviève C Digby, Conrad Kabali, Piotr Kukla, Gary Tse, Benedict Glover, Adrian M Baranchuk
BACKGROUND: Fragmented QRS (fQRS) on electrocardiography is potentially valuable in prognosticating acute pulmonary embolism (PE). ECG is one of the first tests performed in the emergency department, quickly interpretable, noninvasive, inexpensive, and available in remote areas. We aimed to review fQRS's role in PE prognostication. METHODS: We searched MEDLINE, EMBASE, Google Scholar, Web of Science, abstracts, conference proceedings, and reference lists until October 2017...
April 19, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29675617/is-acute-pulmonary-embolism-more-severe-in-the-presence-of-obstructive-sleep-apnea-results-from-an-observational-cohort-study
#5
Dinah Konnerth, Florian Schwarz, Michael Probst, Martin Seidler, Tanja Wagner, Christian Faul, Wolfgang von Scheidt, Martin Schwaiblmair, Thomas M Berghaus
Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p < 0.001), had significantly impaired renal (p < 0.001) and left ventricular functions (p = 0.003), showed significantly elevated troponin I (p = 0.005) and D-dimer levels (p = 0...
April 19, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29675062/indications-retrieval-rate-and-complications-of-inferior-vena-cava-filters-single-center-experience-in-saudi-arabia
#6
Abdullah Bin Shabib, Fahad Alsayed, Saad Aldughaythir, Hanan Habeeb, Sumayyah Al Tamimi, Emad Masuadi, Mohsen Alzahrani, Ali Alaklabi, Azzam Alotaibi, Rajkumar Rajendram, Mosaad Almegren
BACKGROUND: Inferior vena cava (IVC) filter is indicated in patients with acute venous thromboembolism (VTE) in whom therapeutic anticoagulation is contraindicated. While prophylactic insertion of an IVC filter may be considered for patients at high risk of VTE, there are significant differences between clinical guidelines on the role of IVC filters. These discrepancies have arisen predominantly because of the paucity of data on the efficacy and safety of IVC filters. We, therefore, evaluated the indications for filter insertion, the rate of filter retrieval and complications in patients who received IVC filters at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29674240/the-impact-of-antipsychotics-as-a-risk-factor-for-thromboembolism
#7
REVIEW
Ewa A Ogłodek, Marek J Just, Anna D Grzesińska, Aleksander Araszkiewicz, Adam R Szromek
Patients with schizophrenia are predisposed toward developing cardiovascular disease. Although neuroleptics affect the cardiovascular system, it is also important to consider the consequences of the disease itself such as lower physical activity due to living on disability pension, inadequate nutrition, and/or nicotine addiction, being more common among patients with schizophrenia versus the general population. All these factors combined lead to an increased risk of death caused by cardiovascular conditions in schizophrenic patients...
December 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29667126/treatment-of-submassive-and-massive-pulmonary-embolism-a-clinical-practice-survey-from-the-second-annual-meeting-of-the-pulmonary-embolism-response-team-consortium
#8
Thomas M Todoran, Jay Giri, Geoffrey D Barnes, Rachel P Rosovsky, Yuchiao Chang, Michael R Jaff, Kenneth Rosenfield, Christopher Kabrhel
There is a paucity of robust clinical trial data to guide the treatment of acute pulmonary embolism (PE) thus the clinical guidelines rely heavily on expert opinion. Pulmonary Embolism Response Teams (PERT) have been developed to streamline the care of patients with acute PE. We conducted a survey among 100 experts in the field of PE during the second annual meeting of the PERT Consortium. Respondents were queried with respect to their demographic information, clinical practice questions and clinical vignettes...
April 17, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29662868/pulmonary-embolism-presenting-with-acute-abdominal-pain-in-a-girl-with-stable-ankle-fracture-and-inherited-antithrombin-deficiency
#9
Eun Sil Park, Jae Young Cho, Ji-Hyun Seo, Jae Young Lim, Hee-Shang Youn, Hyang-Ok Woo
No abstract text is available yet for this article.
March 2018: Blood Research
https://www.readbyqxmd.com/read/29662744/postoperative-complications-associated-with-rhbmp2-use-in-posterior-posterolateral-lumbar-fusion
#10
Nabil Esmail, Zorica Buser, Jeremiah R Cohen, Darrel S Brodke, Hans-Joerg Meisel, Jong-Beom Park, Jim A Youssef, Jeffrey C Wang, S Tim Yoon
Study Design: Retrospective database review. Objective: Posterior/posterolateral lumbar fusion (PLF) is an effective treatment for a variety of spinal disorders; however, variations in surgical technique have different complication profiles. The aim of our study was to quantify the frequency of various complications in patients undergoing PLF with and without human recombinant bone morphogenetic protein 2 (rhBMP2). Methods: We queried the orthopedic subset of the Medicare database (PearlDiver) between 2005 and 2011 for patients undergoing PLF procedures with and without rhBMP2...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29661787/thromboembolism-in-acute-lymphoblastic-leukemia-results-of-nopho-all2008-protocol-treatment-in-patients-1-45-years
#11
Cecilie Utke Rank, Nina Toft, Ruta Tuckuviene, Kathrine Grell, Ove Juul Nielsen, Thomas Leth Frandsen, Hanne Vibeke Hansen Marquart, Birgitte Klug Albertsen, Ulf Tedgård, Helene Hallböök, Ellen Ruud, Kirsten Brunsvig Jarvis, Petter Quist-Paulsen, Pasi Huttunen, Ulla Wartiovaara-Kautto, Ólafur Gísli Jónsson, Sonata Saulyte Trakymiene, Laimonas Griškevičius, Kadri Saks, Mari Punab, Kjeld Schmiegelow
Thromboembolism frequently occurs during acute lymphoblastic leukemia (ALL) therapy. We prospectively registered thromboembolic events during treatment of 1772 consecutive Nordic/Baltic ALL patients 1-45years treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol (7/2008-4/2017). The 2.5-year cumulative incidence of thromboembolism (N=137) was 7.9% (95% confidence interval (CI) 6.6-9.1); higher in patients ≥10years ( P <.0001). Adjusted hazard ratios (HRa) were associated with greater age (10...
April 16, 2018: Blood
https://www.readbyqxmd.com/read/29660351/association-of-low-hemoglobin-with-symptomatic-venous-thromboembolism-in-acutely-ill-hospitalized-medical-patients-an-apex-trial-substudy
#12
Gerald Chi, C Michael Gibson, Adrian F Hernandez, Russell D Hull, Syed Hassan A Kazmi, Ahmed Younes, Sargun S Walia, Anmol Pitliya, Amandeep Singh, Farima Kahe, Arzu Kalayci, Tarek Nafee, Mathieu Kerneis, Fahad AlKhalfan, Alexander T Cohen, Robert A Harrington, Samuel Z Goldhaber
BACKGROUND: Anemia is a common finding and independent predictor for adverse outcomes in hospitalized patients with medical illness. It remains unclear whether anemia is a risk factor for venous thromboembolism and whether the presence of anemia can refine risk assessment for prediction of venous thromboembolism, thereby adding incremental utility to a validated model. METHODS: In the APEX trial, 7,513 hospitalized medical patients were randomized to receive either betrixaban or standard-of-care enoxaparin for thromboprophylaxis...
April 13, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29659045/surgical-pulmonary-embolectomy-and-catheter-directed-thrombolysis-for-treatment-of-submassive-pulmonary-embolism
#13
Ahmed A Kolkailah, Sameer Hirji, Gregory Piazza, Julius I Ejiofor, Fernando Ramirez Del Val, Jiyae Lee, Siobhan McGurk, Sary F Aranki, Prem S Shekar, Tsuyoshi Kaneko
BACKGROUND: Acute pulmonary embolism (PE) with preserved hemodynamics but right ventricular dysfunction, classified as submassive PE, carries a high risk of mortality. We report the results for patients who did not qualify for medical therapy and required treatment of submassive PE with surgical pulmonary embolectomy and catheter-directed thrombolysis (CDT). METHODS: Between October 1999 and May 2015, 133 submassive PE patients underwent treatment with pulmonary embolectomy (71) and CDT (62)...
April 16, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29655808/impact-of-syncope-and-pre-syncope-on-short-term-mortality-in-patients-with-acute-pulmonary-embolism
#14
Loris Roncon, Marco Zuin, Franco Casazza, Cecilia Becattini, Claudio Bilato, Pietro Zonzin
BACKGROUND: Syncope and pre-syncope are well-known symptoms of acute pulmonary embolism (PE). However, data about their impact on short-term mortality are scant. We assess the short-term mortality (30-day) for all-causes in PE patients admitted with syncope or with pre-syncope, according their hemodynamic status at admission. METHODS: Patients from the prospective Italian Pulmonary Embolism Registry (IPER) were included in the study. At admission, subjects were stratified according to 2008 ESC guidelines (as high- and non-high-risk patients)...
April 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29652041/-alternating-pneumocompression-effective-physiotherapeutic-method-for-the-prevention-of-venous-thromboembolic-complications-in-patients-of-medium-and-high-risk-in-the-acute-period-of-the-stroke
#15
I Y Galyaev
BACKGROUND: the patients presenting with severe post-stroke in the acute period of this condition are characterized by the high risk of venous thromboembolic complications (VTEC), with the most dangerous of them being pulmonary embolism that makes an appreciable contribution to the mortality rate of such patients at the hospital stage of their treatment. Among the physical methods for the prevention of VTE, such as wearing graduated compression stockings (GCS), myoelectrostimulation (MES), pneumatic intermittent compression (PIC), only the latter technique has been shown to be efficient when applied for the treatment of surgical patients during the post-stroke period with the level of evidence 2B and the very uncertain parameters of the impact...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29650544/evaluation-and-management-of-right-sided-heart-failure-a-scientific-statement-from-the-american-heart-association
#16
REVIEW
Marvin A Konstam, Michael S Kiernan, Daniel Bernstein, Biykem Bozkurt, Miriam Jacob, Navin K Kapur, Robb D Kociol, Eldrin F Lewis, Mandeep R Mehra, Francis D Pagani, Amish N Raval, Carey Ward
BACKGROUND AND PURPOSE: The diverse causes of right-sided heart failure (RHF) include, among others, primary cardiomyopathies with right ventricular (RV) involvement, RV ischemia and infarction, volume loading caused by cardiac lesions associated with congenital heart disease and valvular pathologies, and pressure loading resulting from pulmonic stenosis or pulmonary hypertension from a variety of causes, including left-sided heart disease. Progressive RV dysfunction in these disease states is associated with increased morbidity and mortality...
April 12, 2018: Circulation
https://www.readbyqxmd.com/read/29643111/cardiovascular-and-cerebrovascular-emergency-department-visits-associated-with-wildfire-smoke-exposure-in-california-in-2015
#17
Zachary S Wettstein, Sumi Hoshiko, Jahan Fahimi, Robert J Harrison, Wayne E Cascio, Ana G Rappold
BACKGROUND: Wildfire smoke is known to exacerbate respiratory conditions; however, evidence for cardiovascular and cerebrovascular events has been inconsistent, despite biological plausibility. METHODS AND RESULTS: A population-based epidemiologic analysis was conducted for daily cardiovascular and cerebrovascular emergency department (ED) visits and wildfire smoke exposure in 2015 among adults in 8 California air basins. A quasi-Poisson regression model was used for zip code-level counts of ED visits, adjusting for heat index, day of week, seasonality, and population...
April 11, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29629262/thrombolysis-followed-by-apixaban-for-massive-pulmonary-embolism-and-free-floating-thrombus-in-right-ventricle-in-a-patient-with-breast-cancer
#18
Sergio Fasullo, Nicola Morabito, Sergio Cannizzaro, Gioacchino Cosenza, Vito Pinto, Filippo Ganci, Sebastiano Scalzo, Stefania Davi, Giorgio Maringhini
Free-floating thrombus in the right ventricle, associated with a massive acute pulmonary embolism (PE), is a rare phenomenon. PE is an important clinical entity with considerable mortality despite advances in diagnosis and treatment. The prognosis of PE depends on right ventricular dysfunction, myocardial injury markers, and early treatment. In this report, we present the case of a 71-year-old woman with a history of breast cancer admitted to intensive care unit for PE complicated by syncope. Although our case may seem complex because it is not represented in the guidelines, the result was satisfactory and showed how treatment with new anticoagulants (in this case apixaban) after massive thrombolysis of PE could be considered and included in the new guidelines...
January 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29628339/ischemic-stroke-secondary-to-paradoxical-embolism-through-a-pulmonary-arteriovenous-malformation-case-report-and-review-of-the-literature
#19
Ryan Cappa, Jeanette Du, Joseph F Carrera, Jimmy V Berthaud, Andrew M Southerland
Paradoxical embolism due to isolated pulmonary arteriovenous malformation (AVM) is an uncommon cause of ischemic stroke, with the majority occurring in patients who have not yet been diagnosed with their malformation. We report a 32-year-old man who presented with an abrupt onset of right facial weakness and expressive aphasia. Brain magnetic resonance imaging revealed an acute infarct in the left middle cerebral artery territory and chronic infarcts in the bilateral cerebellar hemispheres. A cardioembolic mechanism was initially considered in the setting of perimyocarditis diagnosed a few months earlier...
April 5, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29625928/serum-free-light-chain-difference-and-%C3%AE-2-microglobulin-levels-are-risk-factors-for-thromboembolic-events-in-patients-with-al-amyloidosis
#20
Hyunkyung Park, Ji-Won Kim, Jeonghwan Youk, Youngil Koh, Jeong-Ok Lee, Ki Hwan Kim, Soo-Mee Bang, Inho Kim, Seonyang Park, Sung-Soo Yoon
BACKGROUND: AL amyloidosis might increase the risk of thromboembolism and other plasma cell dyscrasias; however, only a few reports have described the clinical features of thromboembolism. The present study aimed to elucidate the clinical features of thromboembolic events and to identify the risk factors for these events. MATERIALS AND METHODS: The medical records were retrospectively reviewed to define the clinically significant thromboembolic events. RESULTS: A total of 106 patients with biopsy-proven AL amyloidosis were included...
March 15, 2018: Clinical Lymphoma, Myeloma & Leukemia
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