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volatile compound copd

Hussein Traboulsi, Necola Guerrina, Matthew Iu, Dusica Maysinger, Parisa Ariya, Carolyn J Baglole
Air pollution of anthropogenic origin is largely from the combustion of biomass (e.g., wood), fossil fuels (e.g., cars and trucks), incinerators, landfills, agricultural activities and tobacco smoke. Air pollution is a complex mixture that varies in space and time, and contains hundreds of compounds including volatile organic compounds (e.g., benzene), metals, sulphur and nitrogen oxides, ozone and particulate matter (PM). PM0.1 (ultrafine particles (UFP)), those particles with a diameter less than 100 nm (includes nanoparticles (NP)) are considered especially dangerous to human health and may contribute significantly to the development of numerous respiratory and cardiovascular diseases such as chronic obstructive pulmonary disease (COPD) and atherosclerosis...
January 24, 2017: International Journal of Molecular Sciences
Po-Jen Chien, Takuma Suzuki, Masato Tsujii, Ming Ye, Koji Toma, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
Exhaled breath analysis has attracted lots of researchers attention in the past decades due to its advantages such as its non-invasive property and the possibility of continuous monitoring. In addition, several volatile organic compounds in breath have been identified as biomarkers for some diseases. Particularly, studies have pointed out that concentration of isopropanol (IPA) in exhaled air might relate with certain illnesses such as liver disease, chronic obstructive pulmonary (COPD), and lung cancer. In this study, a highly sensitive and selective biochemical gas sensor (bio-sniffer) for the breath IPA concentration determination was constructed and optimized...
May 15, 2017: Biosensors & Bioelectronics
Silvano Dragonieri, Vitaliano N Quaranta, Pierluigi Carratu, Teresa Ranieri, Onofrio Resta
The analysis of volatile organic compounds (VOCs) by an electronic nose (e-nose) is a groundbreaking method that provides distinct exhaled molecular patterns in several respiratory and systemic diseases. It has been shown that an e-nose can detect obstructive sleep apnea (OSA) as well as chronic obstructive pulmonary disease (COPD). OSA and COPD are sometimes associated into the so-called overlap syndrome (OVS). In this pilot study we hypothesized that an e-nose could discriminate the exhaled breath of patients with OVS from that of subjects with OSA and COPD alone...
November 3, 2016: Journal of Breath Research
José Javier Jareño-Esteban, M Ángeles Muñoz-Lucas, Óscar Gómez-Martín, Sergio Utrilla-Trigo, Carlos Gutiérrez-Ortega, Antonio Aguilar-Ros, Luis Collado-Yurrita, Luis Miguel Callol-Sánchez
INTRODUCTION: A major risk factor for chronic obstructive pulmonary disease (COPD) is tobacco smoke, which generates oxidative stress in airways, resulting in the production of volatile organic compounds (VOC). The purpose of this study was to identify VOCs in exhaled breath and to determine their possible use as disease biomarkers. METHOD: Exhaled breath from 100 healthy volunteers, divided into 3groups (never smokers, former smokers and active smokers) and exhaled breath from 57 COPD patients were analyzed...
October 22, 2016: Archivos de Bronconeumología
Lieuwe D Bos, Peter J Sterk, Stephen J Fowler
Exhaled breath contains thousands of volatile organic compounds that reflect the metabolic process occurring in the host both locally in the airways and systemically. They also arise from the environment and airway microbiome. Comprehensive analysis of breath volatile organic compounds (breathomics) provides opportunities for noninvasive biomarker discovery and novel mechanistic insights. Applications in patients with obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease, include not only diagnostics (especially in children and other challenging diagnostic areas) but also identification of clinical treatable traits, such as airway eosinophilia and risk of infection/exacerbation, that are not specific to diagnostic labels...
October 2016: Journal of Allergy and Clinical Immunology
Anders Christiansen, Jesper Rømhild Davidsen, Ingrid Titlestad, Jørgen Vestbo, Jan Baumbach
Chronic obstructive pulmonary disease (COPD) is, according to the WHO, the fifth leading cause of death worldwide, and is expected to increase to rank third in 2030. Few robust biomarkers for COPD exist, and several attempts have been made to find suitable molecular marker candidates. One rising research area is breath analysis, with several published attempts to find exhaled compounds as diagnostic markers. The field is broad and no review of published COPD breath analysis studies exists yet. We have conducted a systematic review examining the state of art and identified 12 suitable papers, which we investigated in detail to extract a list of potential COPD breath marker molecules...
August 31, 2016: Journal of Breath Research
Guojun Zhou, Weiqiang Xiao, Chengyun Xu, Yajun Hu, Xiaokai Wu, Fangfang Huang, Xinbo Lu, Chunyun Shi, Ximei Wu
BACKGROUND: Interleukin-8 (IL-8) functions as a major chemoattractant and plays pivotal roles in the initiation and development of chronic obstructive pulmonary disease (COPD), and tobacco smoke is a most risk factor contributing to the development of COPD. Hence, we have screened some of the tobacco smoke-derived chemical compounds that potentially induce the production of IL-8 in human bronchial epithelium, 16HBE cells. METHODS: Twenty-eight hazardous smoke components belonging to 9 classes including nicotine, ammonia, aromatic amines, polycyclic aromatic hydrocarbons, phenols, carbonyls, hydrocyanic acid, nitrosamines and other volatile organics were used in the experiments...
2016: Tobacco Induced Diseases
Nisreen Shehada, John C Cancilla, Jose S Torrecilla, Enrique S Pariente, Gerald Brönstrup, Silke Christiansen, Douglas W Johnson, Marcis Leja, Michael P A Davies, Ori Liran, Nir Peled, Hossam Haick
Two of the biggest challenges in medicine today are the need to detect diseases in a noninvasive manner and to differentiate between patients using a single diagnostic tool. The current study targets these two challenges by developing a molecularly modified silicon nanowire field effect transistor (SiNW FET) and showing its use in the detection and classification of many disease breathprints (lung cancer, gastric cancer, asthma, and chronic obstructive pulmonary disease). The fabricated SiNW FETs are characterized and optimized based on a training set that correlate their sensitivity and selectivity toward volatile organic compounds (VOCs) linked with the various disease breathprints...
July 26, 2016: ACS Nano
A Gaida, O Holz, C Nell, S Schuchardt, B Lavae-Mokhtari, L Kruse, U Boas, J Langejuergen, M Allers, S Zimmermann, C Vogelmeier, A R Koczulla, J M Hohlfeld
There is increasing evidence that breath volatile organic compounds (VOC) have the potential to support the diagnosis and management of inflammatory diseases such as COPD. In this study we used a novel breath sampling device to search for COPD related VOCs. We included a large number of healthy controls and patients with mild to moderate COPD, recruited subjects at two different sites and carefully controlled for smoking. 222 subjects were recruited in Hannover and Marburg, and inhaled cleaned room air before exhaling into a stainless steel reservoir under exhalation flow control...
April 15, 2016: Journal of Breath Research
M Allers, J Langejuergen, A Gaida, O Holz, S Schuchardt, J M Hohlfeld, S Zimmermann
Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R  =  90. In this study, we evaluated the performance of this GC-IMS under clinical conditions in a COPD study to find correlations between VOCs (10 ppbv to 1 ppmv) and COPD. Furthermore, in order to investigate possible correlations between ultra-low concentrated breath VOCs (0...
April 8, 2016: Journal of Breath Research
Giuseppe Santini, Nadia Mores, Andreu Penas, Rosamaria Capuano, Chiara Mondino, Andrea Trové, Francesco Macagno, Gina Zini, Paola Cattani, Eugenio Martinelli, Andrea Motta, Giuseppe Macis, Giovanni Ciabattoni, Paolo Montuschi
Breathomics, the multidimensional molecular analysis of exhaled breath, includes analysis of exhaled breath with gas-chromatography/mass spectrometry (GC/MS) and electronic noses (e-noses), and metabolomics of exhaled breath condensate (EBC), a non-invasive technique which provides information on the composition of airway lining fluid, generally by high-resolution nuclear magnetic resonance (NMR) spectroscopy or MS methods. Metabolomics is the identification and quantification of small molecular weight metabolites in a biofluid...
2016: Current Topics in Medicinal Chemistry
Raffaele Rocco, Raffaele Antonelli Incalzi, Giorgio Pennazza, Marco Santonico, Claudio Pedone, Isaura Rossi Bartoli, Chiara Vernile, Giuseppe Mangiameli, Antonello La Rocca, Giuseppe De Luca, Gaetano Rocco, Pierfilippo Crucitti
OBJECTIVES: Breath composition may be suggestive of different conditions. E-nose technology has been used to profile volatile organic compounds (VOCs) pattern in the breath of patients compared with that of healthy individuals. BIOsensor-based multisensorial system for mimicking NOse, Tongue and Eyes (BIONOTE) technology differs from Cyranose® based on a set of separate transduction features. On the basis of our previously published experience, we investigated the discriminating ability of BIONOTE in a high-risk population enrolled in a lung cancer screening programme...
April 2016: European Journal of Cardio-thoracic Surgery
Hanaa Shafiek, Federico Fiorentino, Jose Luis Merino, Carla López, Antonio Oliver, Jaume Segura, Ivan de Paul, Oriol Sibila, Alvar Agustí, Borja G Cosío
BACKGROUND: The electronic nose (e-nose) detects volatile organic compounds (VOCs) in exhaled air. We hypothesized that the exhaled VOCs print is different in stable vs. exacerbated patients with chronic obstructive pulmonary disease (COPD), particularly if the latter is associated with airway bacterial infection, and that the e-nose can distinguish them. METHODS: Smell-prints of the bacteria most commonly involved in exacerbations of COPD (ECOPD) were identified in vitro...
2015: PloS One
Elisa Marino, Massimo Caruso, Davide Campagna, Riccardo Polosa
The respiratory system is a primary target of the harmful effects of key air pollutants of health concern. Several air pollutants have been implicated including particulate matter (PM), ozone (O3), nitrogen dioxide (NO2) polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs). It is well known that episodes of exposure to high concentrations of outdoor air pollutants can cause acute respiratory exacerbations. However, there is now increasing evidence suggesting that significant exposure to outdoor air pollutants may be also associated with development of lung cancer and with incident cases of chronic obstructive pulmonary disease (COPD) and respiratory allergies...
September 2015: Therapeutic Advances in Chronic Disease
Anne-Christin Hauschild, Tobias Frisch, Jörg Ingo Baumbach, Jan Baumbach
Computational breath analysis is a growing research area aiming at identifying volatile organic compounds (VOCs) in human breath to assist medical diagnostics of the next generation. While inexpensive and non-invasive bioanalytical technologies for metabolite detection in exhaled air and bacterial/fungal vapor exist and the first studies on the power of supervised machine learning methods for profiling of the resulting data were conducted, we lack methods to extract hidden data features emerging from confounding factors...
2015: Metabolites
Vasiliki Besa, Helmut Teschler, Isabella Kurth, Amir Maqbul Khan, Paul Zarogoulidis, Joerg Ingo Baumbach, Urte Sommerwerck, Lutz Freitag, Kaid Darwiche
Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterized by incompletely reversible airway obstruction. This clinically heterogeneous group of patients is characterized by different phenotypes. Spirometry and clinical parameters, such as severity of dyspnea and exacerbation frequency, are used to diagnose and assess the severity of COPD. The purpose of this study was to investigate whether volatile organic compounds (VOCs) could be detected in the exhaled breath of patients with COPD and whether these VOCs could distinguish COPD patients from healthy subjects...
2015: International Journal of Chronic Obstructive Pulmonary Disease
Janet G Shaw, Annalicia Vaughan, Annette G Dent, Phoebe E O'Hare, Felicia Goh, Rayleen V Bowman, Kwun M Fong, Ian A Yang
Disease progression of chronic obstructive pulmonary disease (COPD) is variable, with some patients having a relatively stable course, while others suffer relentless progression leading to severe breathlessness, frequent acute exacerbations of COPD (AECOPD), respiratory failure and death. Radiological markers such as CT emphysema index, bronchiectasis and coronary artery calcification (CAC) have been linked with increased mortality in COPD patients. Molecular changes in lung tissue reflect alterations in lung pathology that occur with disease progression; however, lung tissue is not routinely accessible...
November 2014: Journal of Thoracic Disease
Parameswaran Nair, Qiang Zhang, John D Brennan
Approximately 50% of asthma exacerbations and a third of COPD exacerbations are associated with an eosinophilic bronchitis. Quantitative cell counts reliably identify the number of eosinophils in sputum and treatment strategies that are guided by sputum eosinophil counts lead to significantly better outcomes than strategies guided by conventional assessments of symptoms and airflow. However, cell counts are not widely available and the results are not available in real time. Similarly, more sophisticated detection methods using immunoassays or genetic analysis via polymerase chain reaction are too costly and thus not amenable to rapid point-of-care diagnosis...
April 2015: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Oriol Sibila, Laia Garcia-Bellmunt, Jordi Giner, Jose Luis Merino, Guillermo Suarez-Cuartin, Alfons Torrego, Ingrid Solanes, Diego Castillo, Jose Luis Valera, Borja G Cosio, Vicente Plaza, Alvar Agusti
BACKGROUND: Airway bacterial colonization by potentially pathogenic microorganisms occurs in a proportion of patients with Chronic Obstructive Pulmonary Disease (COPD). It increases airway inflammation and influences outcomes negatively. Yet, its diagnosis in clinical practice is not straightforward. The electronic nose is a new non-invasive technology capable of distinguishing volatile organic compound (VOC) breath-prints in exhaled breath. We aim to explore if an electronic nose can reliably discriminate COPD patients with and without airway bacterial colonization...
November 2014: Respiratory Medicine
Michael Schivo, Alexander A Aksenov, Angela L Linderholm, Mitchell M McCartney, Jason Simmons, Richart W Harper, Cristina E Davis
Respiratory viral infections such as human rhinovirus (HRV) can lead to substantial morbidity and mortality, especially in people with underlying lung diseases such as asthma and COPD. One proposed strategy to detect viral infections non-invasively is by volatile organic compound (VOC) assessment via analysis of exhaled breath. The epithelial cells are one of the most important cell lines affected during respiratory infections as they are the first line of pathogen defense. Efforts to discover infection-specific biomarkers can be significantly aided by understanding the VOC emanations of respiratory epithelial cells...
September 2014: Journal of Breath Research
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