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https://www.readbyqxmd.com/read/28559466/inhaled-drug-therapy-2016-the-year-in-review
#1
Rajiv Dhand
Some recent salient publications related to inhaled drug therapy are discussed. Unexpectedly, a 2.5-μg once-daily dose of tiotropium (Respimat) had greater efficacy than the 5.0-μg daily dose. Occurrence of a reverse dose response serves to caution us that administering more drug is not always beneficial. Small-airway inflammation contributes to pathogenesis of asthma, especially severe asthma. However, there is no conclusive evidence that the use of small-particle aerosols to target small airways improves clinical outcomes in controlled clinical trials...
May 30, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28503065/serum-cytokine-levels-related-to-exposure-to-volatile-organic-compounds-and-pm2-5-in-dwellings-and-workplaces-in-french-farmers-a-mechanism-to-explain-nonsmoking-copd
#2
Christelle Audi, Nour Baïz, Cara N Maesano, Ollivier Ramousse, Damien Reboulleau, Antoine Magnan, Denis Caillaud, Isabella Annesi-Maesano
Although French farmers smoke less on average than individuals from the general population, they suffer more from COPD. Exposure to biological and chemical air pollutants in the farm may be the cause of these higher COPD rates. This study investigates the role of bio-contaminants, including the relationship of exposure to volatile organic compounds (VOCs) and fine particulate matter (of diameter of 2.5 µm [PM2.5]) objectively measured in the farm settings (dwellings and workplaces) to serum cytokines involved in COPD, in a sample of 72 farmers from 50 farms in the Auvergne region, France...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28440225/observation-of-nonanoic-acid-and-aldehydes-in-exhaled-breath-of-patients-with-lung-cancer
#3
L Callol-Sanchez, M A Munoz-Lucas, O Gomez-Martin, J A Maldonado-Sanz, C Civera-Tejuca, C Gutierrez-Ortega, G Rodriguez-Trigo, J Jareno-Esteban
Lung cancer (LC) is the leading cause of cancer death in men and the second leading cause in women worldwide. The use of low-dose computed tomography in early diagnosis was shown to reduce mortality by 20% with a median follow-up time of 6.5 years. In order to increase profitability and reduce radiation risks and costs, exhaled biomarkers could serve to help establish narrower inclusion criteria. The aim of this study was to identify new, well-founded volatile organic compounds in exhaled breath which distinguish LC patients from chronic obstructive pulmonary disease (COPD) patients and healthy subjects...
April 25, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28125025/inhaled-pollutants-the-molecular-scene-behind-respiratory-and-systemic-diseases-associated-with-ultrafine-particulate-matter
#4
REVIEW
Hussein Traboulsi, Necola Guerrina, Matthew Iu, Dusica Maysinger, Parisa Ariya, Carolyn J Baglole
Air pollution of anthropogenic origin is largely from the combustion of biomass (e.g., wood), fossil fuels (e.g., cars and trucks), incinerators, landfills, agricultural activities and tobacco smoke. Air pollution is a complex mixture that varies in space and time, and contains hundreds of compounds including volatile organic compounds (e.g., benzene), metals, sulphur and nitrogen oxides, ozone and particulate matter (PM). PM0.1 (ultrafine particles (UFP)), those particles with a diameter less than 100 nm (includes nanoparticles (NP)) are considered especially dangerous to human health and may contribute significantly to the development of numerous respiratory and cardiovascular diseases such as chronic obstructive pulmonary disease (COPD) and atherosclerosis...
January 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28043076/bio-sniffer-gas-phase-biosensor-with-secondary-alcohol-dehydrogenase-s-adh-for-determination-of-isopropanol-in-exhaled-air-as-a-potential-volatile-biomarker
#5
Po-Jen Chien, Takuma Suzuki, Masato Tsujii, Ming Ye, Koji Toma, Takahiro Arakawa, Yasuhiko Iwasaki, Kohji Mitsubayashi
Exhaled breath analysis has attracted lots of researchers attention in the past decades due to its advantages such as its non-invasive property and the possibility of continuous monitoring. In addition, several volatile organic compounds in breath have been identified as biomarkers for some diseases. Particularly, studies have pointed out that concentration of isopropanol (IPA) in exhaled air might relate with certain illnesses such as liver disease, chronic obstructive pulmonary (COPD), and lung cancer. In this study, a highly sensitive and selective biochemical gas sensor (bio-sniffer) for the breath IPA concentration determination was constructed and optimized...
May 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27811380/exhaled-breath-profiling-in-patients-with-copd-and-osa-overlap-syndrome-a-pilot-study
#6
Silvano Dragonieri, Vitaliano N Quaranta, Pierluigi Carratu, Teresa Ranieri, Onofrio Resta
The analysis of volatile organic compounds (VOCs) by an electronic nose (e-nose) is a groundbreaking method that provides distinct exhaled molecular patterns in several respiratory and systemic diseases. It has been shown that an e-nose can detect obstructive sleep apnea (OSA) as well as chronic obstructive pulmonary disease (COPD). OSA and COPD are sometimes associated into the so-called overlap syndrome (OVS). In this pilot study we hypothesized that an e-nose could discriminate the exhaled breath of patients with OVS from that of subjects with OSA and COPD alone...
November 3, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27780574/study-of-5-volatile-organic-compounds-in-exhaled-breath-in-chronic-obstructive-pulmonary-disease
#7
José Javier Jareño-Esteban, M Ángeles Muñoz-Lucas, Óscar Gómez-Martín, Sergio Utrilla-Trigo, Carlos Gutiérrez-Ortega, Antonio Aguilar-Ros, Luis Collado-Yurrita, Luis Miguel Callol-Sánchez
INTRODUCTION: A major risk factor for chronic obstructive pulmonary disease (COPD) is tobacco smoke, which generates oxidative stress in airways, resulting in the production of volatile organic compounds (VOC). The purpose of this study was to identify VOCs in exhaled breath and to determine their possible use as disease biomarkers. METHOD: Exhaled breath from 100 healthy volunteers, divided into 3groups (never smokers, former smokers and active smokers) and exhaled breath from 57 COPD patients were analyzed...
May 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27590400/breathomics-in-the-setting-of-asthma-and-chronic-obstructive-pulmonary-disease
#8
Lieuwe D Bos, Peter J Sterk, Stephen J Fowler
Exhaled breath contains thousands of volatile organic compounds that reflect the metabolic process occurring in the host both locally in the airways and systemically. They also arise from the environment and airway microbiome. Comprehensive analysis of breath volatile organic compounds (breathomics) provides opportunities for noninvasive biomarker discovery and novel mechanistic insights. Applications in patients with obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease, include not only diagnostics (especially in children and other challenging diagnostic areas) but also identification of clinical treatable traits, such as airway eosinophilia and risk of infection/exacerbation, that are not specific to diagnostic labels...
October 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27578038/a-systematic-review-of-breath-analysis-and-detection-of-volatile-organic-compounds-in-copd
#9
REVIEW
Anders Christiansen, Jesper Rømhild Davidsen, Ingrid Titlestad, Jørgen Vestbo, Jan Baumbach
Chronic obstructive pulmonary disease (COPD) is, according to the WHO, the fifth leading cause of death worldwide, and is expected to increase to rank third in 2030. Few robust biomarkers for COPD exist, and several attempts have been made to find suitable molecular marker candidates. One rising research area is breath analysis, with several published attempts to find exhaled compounds as diagnostic markers. The field is broad and no review of published COPD breath analysis studies exists yet. We have conducted a systematic review examining the state of art and identified 12 suitable papers, which we investigated in detail to extract a list of potential COPD breath marker molecules...
August 31, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27436995/chemical-constituents-of-tobacco-smoke-induce-the-production-of-interleukin-8-in-human-bronchial-epithelium-16hbe-cells
#10
Guojun Zhou, Weiqiang Xiao, Chengyun Xu, Yajun Hu, Xiaokai Wu, Fangfang Huang, Xinbo Lu, Chunyun Shi, Ximei Wu
BACKGROUND: Interleukin-8 (IL-8) functions as a major chemoattractant and plays pivotal roles in the initiation and development of chronic obstructive pulmonary disease (COPD), and tobacco smoke is a most risk factor contributing to the development of COPD. Hence, we have screened some of the tobacco smoke-derived chemical compounds that potentially induce the production of IL-8 in human bronchial epithelium, 16HBE cells. METHODS: Twenty-eight hazardous smoke components belonging to 9 classes including nicotine, ammonia, aromatic amines, polycyclic aromatic hydrocarbons, phenols, carbonyls, hydrocyanic acid, nitrosamines and other volatile organics were used in the experiments...
2016: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/27383408/silicon-nanowire-sensors-enable-diagnosis-of-patients-via-exhaled-breath
#11
Nisreen Shehada, John C Cancilla, Jose S Torrecilla, Enrique S Pariente, Gerald Brönstrup, Silke Christiansen, Douglas W Johnson, Marcis Leja, Michael P A Davies, Ori Liran, Nir Peled, Hossam Haick
Two of the biggest challenges in medicine today are the need to detect diseases in a noninvasive manner and to differentiate between patients using a single diagnostic tool. The current study targets these two challenges by developing a molecularly modified silicon nanowire field effect transistor (SiNW FET) and showing its use in the detection and classification of many disease breathprints (lung cancer, gastric cancer, asthma, and chronic obstructive pulmonary disease). The fabricated SiNW FETs are characterized and optimized based on a training set that correlate their sensitivity and selectivity toward volatile organic compounds (VOCs) linked with the various disease breathprints...
July 26, 2016: ACS Nano
https://www.readbyqxmd.com/read/27082437/a-dual-center-study-to-compare-breath-volatile-organic-compounds-from-smokers-and-non-smokers-with-and-without-copd
#12
MULTICENTER STUDY
A Gaida, O Holz, C Nell, S Schuchardt, B Lavae-Mokhtari, L Kruse, U Boas, J Langejuergen, M Allers, S Zimmermann, C Vogelmeier, A R Koczulla, J M Hohlfeld
There is increasing evidence that breath volatile organic compounds (VOC) have the potential to support the diagnosis and management of inflammatory diseases such as COPD. In this study we used a novel breath sampling device to search for COPD related VOCs. We included a large number of healthy controls and patients with mild to moderate COPD, recruited subjects at two different sites and carefully controlled for smoking. 222 subjects were recruited in Hannover and Marburg, and inhaled cleaned room air before exhaling into a stainless steel reservoir under exhalation flow control...
April 15, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27058460/measurement-of-exhaled-volatile-organic-compounds-from-patients-with-chronic-obstructive-pulmonary-disease-copd-using-closed-gas-loop-gc-ims-and-gc-apci-ms
#13
M Allers, J Langejuergen, A Gaida, O Holz, S Schuchardt, J M Hohlfeld, S Zimmermann
Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R  =  90. In this study, we evaluated the performance of this GC-IMS under clinical conditions in a COPD study to find correlations between VOCs (10 ppbv to 1 ppmv) and COPD. Furthermore, in order to investigate possible correlations between ultra-low concentrated breath VOCs (0...
April 8, 2016: Journal of Breath Research
https://www.readbyqxmd.com/read/26693732/electronic-nose-and-exhaled-breath-nmr-based-metabolomics-applications-in-airways-disease
#14
REVIEW
Giuseppe Santini, Nadia Mores, Andreu Penas, Rosamaria Capuano, Chiara Mondino, Andrea Trové, Francesco Macagno, Gina Zini, Paola Cattani, Eugenio Martinelli, Andrea Motta, Giuseppe Macis, Giovanni Ciabattoni, Paolo Montuschi
Breathomics, the multidimensional molecular analysis of exhaled breath, includes analysis of exhaled breath with gas-chromatography/mass spectrometry (GC/MS) and electronic noses (e-noses), and metabolomics of exhaled breath condensate (EBC), a non-invasive technique which provides information on the composition of airway lining fluid, generally by high-resolution nuclear magnetic resonance (NMR) spectroscopy or MS methods. Metabolomics is the identification and quantification of small molecular weight metabolites in a biofluid...
2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/26385981/bionote-e-nose-technology-may-reduce-false-positives-in-lung-cancer-screening-programmes%C3%A2
#15
Raffaele Rocco, Raffaele Antonelli Incalzi, Giorgio Pennazza, Marco Santonico, Claudio Pedone, Isaura Rossi Bartoli, Chiara Vernile, Giuseppe Mangiameli, Antonello La Rocca, Giuseppe De Luca, Gaetano Rocco, Pierfilippo Crucitti
OBJECTIVES: Breath composition may be suggestive of different conditions. E-nose technology has been used to profile volatile organic compounds (VOCs) pattern in the breath of patients compared with that of healthy individuals. BIOsensor-based multisensorial system for mimicking NOse, Tongue and Eyes (BIONOTE) technology differs from Cyranose® based on a set of separate transduction features. On the basis of our previously published experience, we investigated the discriminating ability of BIONOTE in a high-risk population enrolled in a lung cancer screening programme...
April 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/26353114/using-the-electronic-nose-to-identify-airway-infection-during-copd-exacerbations
#16
Hanaa Shafiek, Federico Fiorentino, Jose Luis Merino, Carla López, Antonio Oliver, Jaume Segura, Ivan de Paul, Oriol Sibila, Alvar Agustí, Borja G Cosío
BACKGROUND: The electronic nose (e-nose) detects volatile organic compounds (VOCs) in exhaled air. We hypothesized that the exhaled VOCs print is different in stable vs. exacerbated patients with chronic obstructive pulmonary disease (COPD), particularly if the latter is associated with airway bacterial infection, and that the e-nose can distinguish them. METHODS: Smell-prints of the bacteria most commonly involved in exacerbations of COPD (ECOPD) were identified in vitro...
2015: PloS One
https://www.readbyqxmd.com/read/26336597/impact-of-air-quality-on-lung-health-myth-or-reality
#17
REVIEW
Elisa Marino, Massimo Caruso, Davide Campagna, Riccardo Polosa
The respiratory system is a primary target of the harmful effects of key air pollutants of health concern. Several air pollutants have been implicated including particulate matter (PM), ozone (O3), nitrogen dioxide (NO2) polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs). It is well known that episodes of exposure to high concentrations of outdoor air pollutants can cause acute respiratory exacerbations. However, there is now increasing evidence suggesting that significant exposure to outdoor air pollutants may be also associated with development of lung cancer and with incident cases of chronic obstructive pulmonary disease (COPD) and respiratory allergies...
September 2015: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/26065494/carotta-revealing-hidden-confounder-markers-in-metabolic-breath-profiles
#18
Anne-Christin Hauschild, Tobias Frisch, Jörg Ingo Baumbach, Jan Baumbach
Computational breath analysis is a growing research area aiming at identifying volatile organic compounds (VOCs) in human breath to assist medical diagnostics of the next generation. While inexpensive and non-invasive bioanalytical technologies for metabolite detection in exhaled air and bacterial/fungal vapor exist and the first studies on the power of supervised machine learning methods for profiling of the resulting data were conducted, we lack methods to extract hidden data features emerging from confounding factors...
2015: Metabolites
https://www.readbyqxmd.com/read/25759572/exhaled-volatile-organic-compounds-discriminate-patients-with-chronic-obstructive-pulmonary-disease-from-healthy-subjects
#19
Vasiliki Besa, Helmut Teschler, Isabella Kurth, Amir Maqbul Khan, Paul Zarogoulidis, Joerg Ingo Baumbach, Urte Sommerwerck, Lutz Freitag, Kaid Darwiche
Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterized by incompletely reversible airway obstruction. This clinically heterogeneous group of patients is characterized by different phenotypes. Spirometry and clinical parameters, such as severity of dyspnea and exacerbation frequency, are used to diagnose and assess the severity of COPD. The purpose of this study was to investigate whether volatile organic compounds (VOCs) could be detected in the exhaled breath of patients with COPD and whether these VOCs could distinguish COPD patients from healthy subjects...
2015: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/25478195/biomarkers-of-progression-of-chronic-obstructive-pulmonary-disease-copd
#20
REVIEW
Janet G Shaw, Annalicia Vaughan, Annette G Dent, Phoebe E O'Hare, Felicia Goh, Rayleen V Bowman, Kwun M Fong, Ian A Yang
Disease progression of chronic obstructive pulmonary disease (COPD) is variable, with some patients having a relatively stable course, while others suffer relentless progression leading to severe breathlessness, frequent acute exacerbations of COPD (AECOPD), respiratory failure and death. Radiological markers such as CT emphysema index, bronchiectasis and coronary artery calcification (CAC) have been linked with increased mortality in COPD patients. Molecular changes in lung tissue reflect alterations in lung pathology that occur with disease progression; however, lung tissue is not routinely accessible...
November 2014: Journal of Thoracic Disease
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