Wadah Ibrahim, Michael J Wilde, Rebecca L Cordell, Matthew Richardson, Dahlia Salman, Robert C Free, Bo Zhao, Amisha Singapuri, Beverley Hargadon, Erol A Gaillard, Toru Suzuki, Leong L Ng, Tim Coats, Paul Thomas, Paul S Monks, Christopher E Brightling, Neil J Greening, Salman Siddiqui, Rachel Munton, John Le Quesne, Alison H Goodall, Hitesh C Pandya, James C Reynolds, Martha R J Clokie, Nilesh J Samani, Michael R Barer, Jacqueline A Shaw
Acute cardiorespiratory breathlessness accounts for one in eight of all emergency hospitalizations. Early, noninvasive diagnostic testing is a clinical priority that allows rapid triage and treatment. Here, we sought to find and replicate diagnostic breath volatile organic compound (VOC) biomarkers of acute cardiorespiratory disease and understand breath metabolite network enrichment in acute disease, with a view to gaining mechanistic insight of breath biochemical derangements. We collected and analyzed exhaled breath samples from 277 participants presenting acute cardiorespiratory exacerbations and aged-matched healthy volunteers...
November 16, 2022: Science Translational Medicine