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https://www.readbyqxmd.com/read/28081215/genome-wide-association-studies-of-multiple-keratinocyte-cancers
#1
Luba M Pardo, Wen-Qing Li, Shih-Jen Hwang, Joris A C Verkouteren, Albert Hofman, André G Uitterlinden, Peter Kraft, Constance Turman, Jiali Han, Eunyoung Cho, Joanne M Murabito, Daniel Levy, Abrar A Qureshi, Tamar Nijsten
There is strong evidence for a role of environmental risk factors involved in susceptibility to develop multiple keratinocyte cancers (mKCs), but whether genes are also involved in mKCs susceptibility has not been thoroughly investigated. We investigated whether single nucleotide polymorphisms (SNPs) are associated with susceptibility for mKCs. A genome-wide association study (GWAS) of 1,666 cases with mKCs and 1,950 cases with single KC (sKCs; controls) from Harvard cohorts (the Nurses' Health Study [NHS], NHS II, and the Health Professionals Follow-Up Study) and the Framingham Heart Study was carried-out using over 8 million SNPs (stage-1)...
2017: PloS One
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#2
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 4, 2017: Nature
https://www.readbyqxmd.com/read/28048147/su-f-e-14-global-radiation-oncology-education-and-training-in-medical-physics-powered-by-information-and-communication-technologies
#3
W Ngwa, E Sajo, T Ngoma, J Dachi, J Julius Mwaiselage, O Kenton, S Avery
PURPOSE: Recent publications have highlighted the potential of Information and Communication Technologies (ICTs) to catalyze collaborations in cancer care, research and education in global radiation oncology. This work reports on the use of ICTs for global Medical Physics education and training across three countries: USA, Tanzania and Kuwait METHODS: An online education platform was established by Radiation Oncology Faculty from Harvard Medical School, and the University of Pennsylvania with integrated Medical Physics Course modules accessible to trainees in Tanzania via partnership with the Muhimbili University of Health and Allied Sciences, and the Ocean Road Cancer Institute...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27984760/spatial-and-temporal-variation-in-endotoxin-and-pm10-concentrations-in-ambient-air-in-a-livestock-dense-area
#4
Myrna M T de Rooij, Dick J J Heederik, Floor Borlée, Gerard Hoek, Inge M Wouters
Several studies have reported associations between farming and respiratory health in neighboring residents. Health effects are possibly linked to fine dust and endotoxin emissions from livestock farms. Little is known about levels of these air pollutants in ambient air in livestock dense areas. We aimed to explore temporal and spatial variation of PM10 and endotoxin concentrations, and the association with livestock-related spatial and meteorological temporal determinants. From March till September 2011, one week average PM10 samples were collected using Harvard Impactors at eight sites (residential gardens) representing a variety of nearby livestock-related characteristics...
December 13, 2016: Environmental Research
https://www.readbyqxmd.com/read/27968890/patient-physician-trust-in-china-a-workshop-summary
#5
Cheris S C Chan, Yu Cheng, Yali Cong, Zhizheng Du, Shanlian Hu, Amanda Kerrigan, Arthur Kleinman, Mengfeng Li, Benjamin Liebman, Yonghui Ma, Jing-Bao Nie, Daniel F C Tsai, Duujian Tsai, Joseph D Tucker, Lijie Wang, Bonnie Wong, William C W Wong, Zeping Xiao, Juncai Xu, Yunxiang Yan, Yang Yang, Daqing Zhang, Mingjie Zhao, Jianfeng Zhu, Wei Zhu
BACKGROUND: Patient-physician mistrust has become deeply embedded in medical clinics within a wide variety of settings, including many in China. The purpose of this research was to develop a series of actionable policy recommendations to rebuild patient-physician trust in China. METHODS: Our interdisciplinary group included experts in medicine, public health, philosophy, ethics, law, regulation, China studies, anthropology, sociology, and communications. Recommendations were identified by team members and presented at a two-day workshop at the Harvard Center, Shanghai, China...
October 2016: Lancet
https://www.readbyqxmd.com/read/27932020/night-eating-syndrome-and-the-severity-of-self-reported-depressive-symptoms-from-the-korea-nurses-health-study-analysis-of-propensity-score-matching-and-ordinal-regression
#6
O-S Kim, M S Kim, J E Lee, H Jung
OBJECTIVES: The prevalence of night-eating syndrome (NES) and depression is increasing worldwide. Although nurses, in particular, are exposed to work in an environment of irregular eating, shift work, and stressful settings, limited research exist. In fact, the prevalence of NES among Korean nurses has never been reported. The aim of this study was to determine the prevalence of NES as well as the association between NES and severity of self-reported depressive symptoms among South Korean female nurses...
December 2016: Public Health
https://www.readbyqxmd.com/read/27925814/a-course-on-religion-and-public-health-at-harvard
#7
Tyler J VanderWeele, Harold G Koenig
No abstract text is available yet for this article.
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27914853/monitoring-the-fitness-of-antiviral-resistant-influenza-strains-during-an-epidemic-a-mathematical-modelling-study
#8
Kathy Leung, Marc Lipsitch, Kwok Yung Yuen, Joseph T Wu
BACKGROUND: Antivirals (eg, oseltamivir) are important for mitigating influenza epidemics. In 2007, an oseltamivir-resistant influenza seasonal A H1N1 strain emerged and spread to global fixation within 1 year. This event showed that antiviral-resistant (AVR) strains can be intrinsically more transmissible than their contemporaneous antiviral-sensitive (AVS) counterpart. Surveillance of AVR fitness is therefore essential. Our objective was to develop a simple method for estimating AVR fitness from surveillance data...
November 30, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27905017/an-evaluation-of-preparedness-delivery-and-impact-of-surgical-and-anesthesia-care-in-madagascar-a-framework-for-a-national-surgical-plan
#9
Emily Bruno, Michelle C White, Linden S Baxter, Vaonandianina Agnès Ravelojaona, Hasiniaina Narindria Rakotoarison, Hery Harimanitra Andriamanjato, Kristin L Close, Alison Herbert, Nakul Raykar, Saurabh Saluja, Mark G Shrime
BACKGROUND: The Lancet Commission on Global Surgery (LCoGS) described the lack of access to safe, affordable, timely surgical, and anesthesia care. It proposed a series of 6 indicators to measure surgery, accompanied by time-bound targets and a template for national surgical planning. To date, no sub-Saharan African country has completed and published a nationwide evaluation of its surgical system within this framework. METHOD: Mercy Ships, in partnership with Harvard Medical School and the Madagascar Ministry of Health, collected data on the 6 indicators from 22 referral hospitals in 16 out of 22 regions of Madagascar...
November 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27875052/the-role-of-academic-institutions-in-fostering-interprofessional-educational-models
#10
Romesh P Nalliah, Lisa A Thompson, Lee A Wellman, Brian J Swann
Dentistry is much broader than the conditions it treats. In 2014, the Harvard School of Dental Medicine convened a leadership forum, "Put Your Money Where Your Mouth Is: The Economic Imperative of Oral Health." Based on the goals of that initiative to advocate for an integrated healthcare system, the authors have presented pertinent information from two major research projects and two major clinical programs, which, collectively, aim to bring oral health into primary care and raise the awareness of the connections between oral health and systemic health...
November 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27837523/linguistic-evidence-for-the-failure-mindset-as-a-predictor-of-life-span-longevity
#11
Ian B Penzel, Michelle R Persich, Ryan L Boyd, Michael D Robinson
BACKGROUND: When people think that their efforts will fail to achieve positive outcomes, they sometimes give up their efforts after control, which can have negative health consequences. PURPOSE: Problematic orientations of this type, such as pessimism, helplessness, or fatalism, seem likely to be associated with a cognitive mindset marked by higher levels of accessibility for failure words or concepts. Thus, the purpose of the present research was to determine whether there are individual differences in the frequency with which people think about failure, which in turn are likely to impact health across large spans of time...
November 11, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27804900/resource-activation-for-treating-post-traumatic-stress-disorder-co-morbid-symptoms-and-impaired-functioning-a-randomized-controlled-trial-in-cambodia
#12
C Steinert, P J Bumke, R L Hollekamp, A Larisch, F Leichsenring, H Mattheß, S Sek, U Sodemann, M Stingl, T Ret, H Vojtová, W Wöller, J Kruse
BACKGROUND: Mental health morbidity in post-conflict settings is high. Nevertheless, randomized controlled trials of psychotherapy on site are rare. Our aim was to integrate rigorous research procedures into a humanitarian programme and test the efficacy of resource activation (ROTATE) in treating post-traumatic stress disorder (PTSD), co-morbid symptoms and impaired functioning in Cambodia. METHOD: A total of 86 out-patients with PTSD were randomly assigned to five sessions of ROTATE (n = 53) or a 5-week waiting-list control (WLC) condition (n = 33)...
November 2, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27779619/a-database-of-human-exposomes-and-phenomes-from-the-us-national-health-and-nutrition-examination-survey
#13
Chirag J Patel, Nam Pho, Michael McDuffie, Jeremy Easton-Marks, Cartik Kothari, Isaac S Kohane, Paul Avillach
The National Health and Nutrition Examination Survey (NHANES) is a population survey implemented by the Centers for Disease Control and Prevention (CDC) to monitor the health of the United States whose data is publicly available in hundreds of files. This Data Descriptor describes a single unified and universally accessible data file, merging across 255 separate files and stitching data across 4 surveys, encompassing 41,474 individuals and 1,191 variables. The variables consist of phenotype and environmental exposure information on each individual, specifically (1) demographic information, physical exam results (e...
October 25, 2016: Scientific Data
https://www.readbyqxmd.com/read/27755522/-about-the-introduction-the-criteria-of-brain-death-in-poland-in-1984
#14
REVIEW
Anna Paprocka-Lipińska
Significant recovery of discussion about the need for the formulation of criteria of death was provoked due to the progress of medicine. Development of anaesthesiology and intensive therapy, introduction of new resuscitation techniques and devices, which are increasingly better able to maintain and sometimes even replace functions of the respiratory or cardiovascular system, which are essential for the survival meant that existing for centuries, socially accepted classical criteria of death, based on cessation of breath and circulation, are no longer sufficient...
September 29, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27692049/randomized-prospective-study-of-the-impact-of-a-sleep-health-program-on-firefighter-injury-and-disability
#15
Jason P Sullivan, Conor S O'Brien, Laura K Barger, Shantha M W Rajaratnam, Charles A Czeisler, Steven W Lockley
STUDY OBJECTIVES: Firefighters' schedules include extended shifts and long work weeks which cause sleep deficiency and circadian rhythm disruption. Many firefighters also suffer from undiagnosed sleep disorders, exacerbating fatigue. We tested the hypothesis that a workplace-based Sleep Health Program (SHP) incorporating sleep health education and sleep disorders screening would improve firefighter health and safety compared to standard practice. DESIGN: Prospective station-level randomized, field-based intervention...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27670090/quality-of-basic-maternal-care-functions-in-health-facilities-of-five-african-countries-an-analysis-of-national-health-system-surveys
#16
Margaret E Kruk, Hannah H Leslie, Stéphane Verguet, Godfrey M Mbaruku, Richard M K Adanu, Ana Langer
BACKGROUND: Global efforts to increase births at health-care facilities might not reduce maternal or newborn mortality if quality of care is insufficient. However, little systematic evidence exists for the quality at health facilities caring for women and newborn babies in low-income countries. We analysed the quality of basic maternal care functions and its association with volume of deliveries and surgical capacity in health-care facilities in five sub-Saharan African countries. METHODS: In this analysis, we combined nationally representative health system surveys (Service Provision Assessments by the Demographic and Health Survery Programme) with data for volume of deliveries and quality of delivery care from Kenya, Namibia, Rwanda, Tanzania, and Uganda...
November 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27666095/using-a-change-model-to-reduce-the-risk-of-surgical-site-infection
#17
Mel Burden
A surgical site infection (SSI) surveillance module completed in 2014 highlighted that infection rates for breast surgery inpatients and readmissions at an acute trust had increased to 2.2%, from 0.5% in 2012. The national benchmark for 2014 established by Public Health England (PHE) was 1.0%. This demonstrated a greater than fourfold absolute increase in SSI for breast surgery during these periods. The infection rate could have been due to chance, but warranted investigation. The results were presented to the breast team and used to drive practice transformation through audit and observation, identifying areas of change to improve patient safety...
September 22, 2016: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/27585812/latino-family-participation-in-youth-mental-health-services-treatment-retention-engagement-and-response
#18
Theresa L Kapke, Alyson C Gerdes
Although researchers have identified a multitude of factors that contribute to family participation in mental health services, few studies have examined them specifically for Latino youth and their families in the U.S., a population that continues to experience significant disparities related to the availability, accessibility, and quality of mental health services. Latino youth and their families are at greater risk of dropping out of treatment prematurely and demonstrating poor treatment engagement, both of which have subsequent negative effects on treatment response outcomes...
September 1, 2016: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/27583997/frame-of-reference-training-establishing-reliable-assessment-of-teaching-effectiveness
#19
Lori R Newman, Dara Brodsky, Richard N Jones, Richard M Schwartzstein, Katharyn Meredith Atkins, David H Roberts
INTRODUCTION: Frame-of-reference (FOR) training has been used successfully to teach faculty how to produce accurate and reliable workplace-based ratings when assessing a performance. We engaged 21 Harvard Medical School faculty members in our pilot and implementation studies to determine the effectiveness of using FOR training to assess health professionals' teaching performances. METHODS: All faculty were novices at rating their peers' teaching effectiveness. Before FOR training, we asked participants to evaluate a recorded lecture using a criterion-based peer assessment of medical lecturing instrument...
2016: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/27578485/genetic-variants-in-the-piwi-pirna-pathway-gene-dcp1a-predict-melanoma-disease-specific-survival
#20
Weikang Zhang, Hongliang Liu, Jieyun Yin, Wenting Wu, Dakai Zhu, Christopher I Amos, Shenying Fang, Jeffrey E Lee, Yi Li, Jiali Han, Qingyi Wei
The Piwi-piRNA pathway is important for germ cell maintenance, genome integrity, DNA methylation and retrotransposon control and thus may be involved in cancer development. In this study, we comprehensively analyzed prognostic roles of 3,116 common SNPs in PIWI-piRNA pathway genes in melanoma disease-specific survival. A published genome-wide association study (GWAS) by The University of Texas M.D. Anderson Cancer Center was used to identify associated SNPs, which were later validated by another GWAS from the Harvard Nurses' Health Study and Health Professionals Follow-up Study...
December 15, 2016: International Journal of Cancer. Journal International du Cancer
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