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https://www.readbyqxmd.com/read/28522728/draft-genome-sequence-of-mycobacterium-abscessus-bamboo
#1
Michelle Yee, David Klinzing, Jun-Rong Wei, Martin Gengenbacher, Eric J Rubin, Thomas Dick
Mycobacterium abscessus, an intrinsically multidrug-resistant pathogen, causes chronic incurable lung disease. New drugs for this emerging pathogen represent an urgent unmet medical need. Here, we report a draft genome sequence of M. abscessus Bamboo, a clinical isolate used as a screening strain for drug discovery.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28522316/mycobacteriological-characteristics-and-treatment-outcomes-in-extrapulmonary-mycobacterium-abscessus-complex-infection
#2
Suk Hyeon Jeong, Su-Young Kim, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck, Sung Jae Shin, Won-Jung Koh
OBJECTIVES: Differentiation between Mycobacterium abscessus and M. massiliense and determination of the presence of inducible resistance to macrolide antibiotics are important factors in the management of patients with M. abscessus complex (MABC) infection. Unlike pulmonary MABC infection, little information on extrapulmonary MABC infection is available. METHODS: We performed molecular identification of clinical isolates and assessed the clinical characteristics and treatment outcomes of 20 consecutive patients with extrapulmonary MABC infections...
May 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28502947/intractable-cutaneous-nontuberculous-mycobacteriosis-mycobacterium-abscessus-during-treatment-for-systemic-lupus-erythematosus
#3
Dai Kishida, Mitsuto Sato, Chinatsu Kobayashi, Ken-Ichi Ueno, Tomomi Kinoshita, Minori Kodaira, Yasuhiro Shimojima, Wataru Ishii, Atsuhito Ushiki, Shu-Ichi Ikeda
Mycobacterium abscessus infection tends to occur in patients with an advanced immunocompromised status. We encountered a case of intractable cutaneous M. abscessus infection that developed in a patient with systemic lupus erythematosus (SLE) during maintenance therapy. A 28-year-old woman developed a fever and redness of the skin on her buttocks. General antibacterial therapy was ineffective, and acid-fast bacteria were detected in the biopsy that was conducted to differentiate the dermal symptoms of SLE. The clinical findings eventually improved; however, the symptoms recurred multiple times during treatment...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28495380/outcomes-associated-with-antibiotic-regimens-for-treatment-of-mycobacterium-abscessus-in-cystic-fibrosis-patients
#4
Alison DaCosta, Cameron L Jordan, Olivia Giddings, Feng-Chang Lin, Peter Gilligan, Charles R Esther
BACKGROUND: Mycobacterium abscessus infection is associated with declining lung function in cystic fibrosis (CF), but there is little evidence on clinical efficacy to guide treatment. METHODS: Retrospective review of 37 CF patients treated for M. abscessus respiratory infection at a single center from 2006 to 2014. Outcomes included change in FEV1 at 30, 60, 90, 180, and 365days after treatment and clearance of M. abscessus from sputum cultures. RESULTS: Lung function was significantly improved after 30 and 60days of treatment, but not at later time points...
May 8, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28486671/elucidation-of-mycobacterium-abscessus-aminoglycoside-and-capreomycin-resistance-by-targeted-deletion-of-three-putative-resistance-genes
#5
Anna Rominski, Petra Selchow, Katja Becker, Juliane K Brülle, Michael Dal Molin, Peter Sander
Objectives: Mycobacterium abscessus is innately resistant to a variety of drugs thereby limiting therapeutic options. Bacterial resistance to aminoglycosides (AGs) is conferred mainly by AG-modifying enzymes, which often have overlapping activities. Several putative AG-modifying enzymes are encoded in the genome of M. abscessus . The aim of this study was to investigate the molecular basis underlying AG resistance in M. abscessus . Methods: M. abscessus deletion mutants deficient in one of three genes potentially involved in AG resistance, aac(2 ' ) , eis1 and eis2 , were generated by targeted gene inactivation, as were combinatorial double and triple deletion mutants...
May 9, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28474649/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-in-diagnosing-mediastinal-lymphadenopathy
#6
Tanushree Gahlot, Ujjwal Parakh, Kusum Verma, Bobby Bhalotra, Neeraj Jain
CONTEXT: The diagnosis of mediastinal lymphadenopathy is always a challenge. There always a need of a technique that is highly accurate as well as safe for diagnosis the same. AIMS: The aim of the study is to assess the clinical usefulness and safety profile of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in diagnosing the patients with mediastinal lymphadenopathy. SETTINGS AND DESIGN: This was an observational prospective study...
May 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28462746/disinfectant-susceptibility-profiling-of-glutaraldehyde-resistant-nontuberculous-mycobacteria
#7
Winona Burgess, Alyssa Margolis, Sara Gibbs, Rafael Silva Duarte, Mary Jackson
OBJECTIVE Activated alkaline glutaraldehyde (GTA) remains one of the most widely used high-level disinfectants worldwide. However, several reports have highlighted the potential for nontuberculous mycobacteria to develop high-level resistance to this product. Because aldehyde resistance may lead to cross-resistance to other biocides, we investigated the susceptibility profile of GTA-resistant Mycobacterium chelonae and M. abscessus isolates to various disinfectant chemistries. METHODS High-level disinfectants commonly used in the reprocessing of endoscopes and other heat-sensitive, semicritical medical equipment, including different formulations of aldehyde-based products and oxidizing agents, were tested against 10 slow- and fast-growing, GTA-susceptible and GTA-resistant, Mycobacterium isolates in suspension tests and carrier tests at different temperatures...
May 2, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28461147/microbiological-and-clinical-outcomes-of-treating-non-mac-ntm-pulmonary-disease-a-systematic-review-and-meta-analysis
#8
R Diel, F C Ringshausen, E Richter, L Welker, J Schmitz, A Nienhaus
BACKGROUND: Pulmonary disease caused by non-tuberculous mycobacteria (NTM) is steadily increasing worldwide. METHODS: A systematic review of Non-Mycobacterium avium complex studies published prior to October 2016 was conducted with respect to microbiological and clinical outcomes of current treatment regimens. RESULTS: We retrieved 352 citations; these yielded 24 studies eligible for evaluation. Sixteen studies were retrospective chart reviews, 3 were prospective and only 5 randomized...
April 28, 2017: Chest
https://www.readbyqxmd.com/read/28436419/nontuberculous-mycobacteria-in-gastrostomy-fed-patients-with-cystic-fibrosis
#9
H Al-Momani, A Perry, R Jones, S Bourke, S Doe, J Perry, A Anderson, T Forrest, I Forrest, M Griffin, M Brodlie, J Pearson, C Ward
Multi-drug resistant Mycobacterium abscessus complex (MABSC) is a form of Nontuberculous mycobacteria (NTM) of special, international concern in Cystic Fibrosis (CF). We hypothesised that gastric juice and percutaneous endoscopic gastrostomy (PEG) feeding devices might yield MABSC isolates. Gastric juice and sputa from sixteen adult PEG fed CF patients and five replaced PEG tubes were studied. Bacterial and fungal isolates were cultured. Mycobacterium were identified by rpoB, sodA and hsp65 gene sequencing and strain typed using variable number tandem repeat...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421165/the-diverse-cellular-and-animal-models-to-decipher-the-physiopathological-traits-of-mycobacterium-abscessus-infection
#10
REVIEW
Audrey Bernut, Jean-Louis Herrmann, Diane Ordway, Laurent Kremer
Mycobacterium abscessus represents an important respiratory pathogen among the rapidly-growing non-tuberculous mycobacteria. Infections caused by M. abscessus are increasingly found in cystic fibrosis (CF) patients and are often refractory to antibiotic therapy. The underlying immunopathological mechanisms of pathogenesis remain largely unknown. A major reason for the poor advances in M. abscessus research has been a lack of adequate models to study the acute and chronic stages of the disease leading to delayed progress of evaluation of therapeutic efficacy of potentially active antibiotics...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28407432/diagnosis-of-biofilm-infections-in-cystic-fibrosis-patients
#11
REVIEW
Niels Høiby, Thomas Bjarnsholt, Claus Moser, Peter Østrup Jensen, Mette Kolpen, Tavs Qvist, Kasper Aanaes, Tanja Pressler, Marianne Skov, Oana Ciofu
Chronic Pseudomonas aeruginosa biofilm lung infection in cystic fibrosis patients is the best described biofilm infection in medicine. The initial focus can be the paranasal sinuses and then follows repeated colonization and infection of the lungs by aspiration. The matrix of the biofilms is dominated by alginate and the pathogenesis of tissue damage is immune complex-mediated chronic inflammation dominated by polymorphonuclear leukocytes and their products (DNA, oxygen radicals and proteases). The P. aeruginosa biofilm infection can be diagnosed by microscopy of lung tissue, sputum and mucus from the paranasal sinuses, where aggregates of the bacteria are found surrounded by the abundant alginate matrix...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28396540/rifabutin-is-active-against-mycobacterium-abscessus-complex
#12
Dinah Binte Aziz, Jian Liang Low, Mu-Lu Wu, Martin Gengenbacher, Jeanette W P Teo, Véronique Dartois, Thomas Dick
Lung infections with Mycobacterium abscessus are emerging as a global threat to individuals with cystic fibrosis and other patient groups. Recent evidence for human-to-human transmission worsens the situation. M. abscessus is an intrinsically multidrug resistant pathogen showing resistance even against standard anti tuberculosis drugs such as rifampicin. Here, our objective was to identify existing drugs that may be employed for the treatment of M. abscessus lung disease. A collection of more than 2700 approved drugs was screened at a single point concentration against an M...
April 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28367029/biofilm-colonization-in-chronic-treatment-refractory-infections-presenting-with-discharging-sinuses-a-study-in-a-tertiary-care-hospital-of-eastern-india
#13
Asmita De, Hirak Jyoti Raj, Jayeeta Haldar, Poulami Mukherjee, Prasanta Kumar Maiti
INTRODUCTION: Treatment refractory chronic recurrent infections mean those chronic infections which recur by same causal agents with similar drug responsiveness after apparent relief following full course of recommended antimicrobial management. MATERIALS AND METHODS: Fifty different samples were collected from patients with chronic surgical site infections, laparoscopic port site infections, anal fistula, mesh hernioplasty, chronic dacryocystitis, chronic osteomyelitis, and chronic burn wounds...
April 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28364441/survival-after-lung-transplantation-for-cystic-fibrosis-in-sweden%C3%A2
#14
Marita Gilljam, Ulla Nyström, Göran Dellgren, Ingrid Skog, Lennart Hansson
OBJECTIVES: In Sweden, lung transplantation has been performed in patients with end-stage lung disease since 1990. We assessed survival after lung transplantation for cystic fibrosis (CF) with focus on early mortality and outcome for patients infected with certain multiresistant bacteria, considered a relative contraindication for lung transplantation. METHODS: Review of CF and transplant databases and patient charts. The Kaplan-Meier method and log-rank test were used for survival analysis and group comparison...
March 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28348153/a-clofazimine-containing-regimen-for-the-treatment-of-mycobacterium-abscessus-lung-disease
#15
Bumhee Yang, Byung Woo Jhun, Seong Mi Moon, Hyun Lee, Hye Yun Park, Kyeongman Jeon, Dae Hun Kim, Su-Young Kim, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Patients with lung disease caused by Mycobacterium abscessus subspecies abscessus (hereafter M. abscessus) typically have poor treatment outcomes. Although clofazimine (CFZ) has been increasingly used in the treatment of M. abscessus lung disease in clinical practice, there are no published data on its effectiveness for this disease. This study sought to evaluate the clinical efficacy of a CFZ-containing regimen for the treatment of M. abscessus lung disease. We performed a retrospective review of the medical records of 42 patients with M...
March 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28344532/atypical-mycobacterial-infections-of-the-upper-extremity-becoming-more-atypical
#16
Mariela Lopez, Julie Croley, Kevin D Murphy
Background: Atypical mycobacterial infections are uncommon and characterized by a chronic, indolent course before diagnosis. Historically, these infections are associated with marine-related injury and/or immune dysfunction. Our institution has successfully diagnosed and treated an increasing number of these infections. The objective of this study is to review our experience with these rare infections and verify the developing trends encountered. Methods: A retrospective review was performed for patients with positive nontuberculous mycobacterial cultures of the upper extremity from 2000 to 2013...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28337426/pathogen-identification-in-suspected-cases-of-pyogenic-spondylodiscitis
#17
Ahmad Farajzadeh Sheikh, Azar D Khosravi, Hamed Goodarzi, Roohangiz Nashibi, Alireaza Teimouri, Azim Motamedfar, Reza Ranjbar, Sara Afzalzadeh, Mehrandokht Cyrus, Mohammad Hashemzadeh
Pyogenic spinal infection continues to represent a worldwide problem. In approximately one-third of patients with pyogenic spondylodiscitis, the infectious agent is never identified. Of the cases that lead to organismal identification, bacteria are more commonly isolated from the spine rather than fungi and parasites. This study applied universal prokaryotic 16S rRNA PCR as a rapid diagnostic tool for the detection of bacterial agents in specimens from patients suspected of pyogenic spondylodiscitis. Gram and Ziehl-Neelsen staining were used as a preliminary screening measure for microbiologic evaluation of patient samples...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28333340/evaluation-of-the-new-genotype-ntm-dr-kit-for-the-molecular-detection-of-antimicrobial-resistance-in-non-tuberculous-mycobacteria
#18
Faiza Mougari, Jade Loiseau, Nicolas Veziris, Christine Bernard, Béatrice Bercot, Wladimir Sougakoff, Vincent Jarlier, Laurent Raskine, Emmanuelle Cambau
Objectives: Non-tuberculous mycobacteria (NTM) are emerging pathogens causing difficult-to-treat infections. We tested a new assay (GenoType NTM-DR) that detects natural and acquired resistance mechanisms to macrolides and aminoglycosides in frequently isolated NTM species. Methods: Performance was assessed on 102 isolates including reference strains [16 Mycobacterium avium , 10 Mycobacterium intracellulare , 8 Mycobacterium chimaera , 15 Mycobacterium chelonae and 53 Mycobacterium abscessus (including subsp...
June 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28331837/public-health-relevance-of-non-tuberculous-mycobacteria-among-afb-positive-sputa
#19
Prabha Desikan, Karuna Tiwari, Nikita Panwalkar, Saima Khaliq, Manju Chourey, Reeta Varathe, Shaina Beg Mirza, Arun Sharma, Sridhar Anand, Manoj Pandey
BACKGROUND: Sputum smear microscopy for acid fast bacilli (AFB) is used by most public health programmes to detect tuberculosis. While most AFB in countries endemic for tuberculosis are Mycobacterium tuberculosis (MTB), some may also be non-tuberculous mycobacteria (NTM). The inability to differentiate NTM from MTB by sputum smear microscopy may lead to erroneous diagnoses of tuberculosis, leading in turn to inappropriate therapy. METHODS: This was a retrospective study of consecutive sputum samples received from November 2013 to March 2015 in the Department of Microbiology, Bhopal Memorial Hospital & Research Centre, Bhopal, India...
March 2017: Germs
https://www.readbyqxmd.com/read/28330892/in-vitro-susceptibility-testing-of-tedizolid-against-nontuberculous-mycobacteria
#20
Barbara A Brown-Elliott, Richard J Wallace
Tedizolid is a new oxazolidinone with improved in vitro and intracellular potency against Mycobacterium tuberculosis, including multidrug resistant strains, and some species of nontuberculous mycobacteria (NTM) compared with linezolid.Using the current Clinical and Laboratory Standards Institute (CLSI) recommended method of broth microdilution, susceptibility testing of 170 isolates of rapidly growing mycobacteria showed equivalent or lower (1- to 8-fold MIC50 and/or MIC90 values) for tedizolid compared to linezolid...
March 22, 2017: Journal of Clinical Microbiology
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