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mycobacterium abscessus

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https://www.readbyqxmd.com/read/29343644/identification-of-genes-required-for-mycobacterium-abscessus-growth-in-vivo-with-a-prominent-role-of-the-esx-4-locus
#1
Laura Laencina, Violaine Dubois, Vincent Le Moigne, Albertus Viljoen, Laleh Majlessi, Justin Pritchard, Audrey Bernut, Laura Piel, Anne-Laure Roux, Jean-Louis Gaillard, Bérengère Lombard, Damarys Loew, Eric J Rubin, Roland Brosch, Laurent Kremer, Jean-Louis Herrmann, Fabienne Girard-Misguich
Mycobacterium abscessus, a rapidly growing mycobacterium (RGM) and an opportunistic human pathogen, is responsible for a wide spectrum of clinical manifestations ranging from pulmonary to skin and soft tissue infections. This intracellular organism can resist the bactericidal defense mechanisms of amoebae and macrophages, an ability that has not been observed in other RGM. M. abscessus can up-regulate several virulence factors during transient infection of amoebae, thereby becoming more virulent in subsequent respiratory infections in mice...
January 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29332650/amplification-of-hsp-65-gene-and-usage-of-restriction-endonuclease-for-identification-of-non-tuberculous-rapid-grower-mycobacterium
#2
Ajoy Kumar Verma, Rohit Sarin, Vijay Kumar Arora, Gavish Kumar, Jyoti Arora, Paras Singh, Vithal Prasad Myneedu
BACKGROUND: The rapid grower mycobacteria have emerged as significant group of human pathogen amongst the Runyon group IV organisms that are capable of causing infection in both the healthy and immunocompromised hosts. Study aimed to identification of species amongst rapid grower non tuberculous mycobacterial isolates by polymerase chain reaction - restriction enzyme analysis (PRA). Analysis and comparison of results with standard biochemical tests. METHODS: Rapid grower non tuberculous mycobacteria had been collected from liquid culture section during the study period...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29329759/treatment-outcomes-of-macrolide-susceptible-mycobacterium-abscessus-lung-disease
#3
Hayoung Choi, Byung Woo Jhun, Su-Young Kim, Dae Hun Kim, Hyun Lee, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Mycobacterium abscessus lung disease is difficult to treat due to inducible resistance to macrolides. However, 15%-20% of isolates are macrolide susceptible. In 14 patients with macrolide-susceptible M. abscessus lung disease, all isolates had nonfunctional erm(41) gene, and sputum culture conversion rate was achieved in 93% (13/14) following antibiotic therapy.
December 16, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29311080/mycobacterium-abscessus-smooth-and-rough-morpohotypes-form-antimicrobial-tolerant-biofilm-phenotypes-but-are-killed-by-acetic-acid
#4
Gillian Clary, Smitha Sasindran, Nathan Nesbitt, Laurel Mason, Sara Cole, Abul Azad, Karen McCoy, Larry S Schlesinger, Luanne Hall-Stoodley
Mycobacterium abscessus has emerged as an important pathogen in people with chronic inflammatory lung diseases such as cystic fibrosis, and recent reports suggest that it may be transmissible by fomites. M. abscessus exhibits two major colony morphology variants: a smooth morphotype (MaSm ) and a rough morphotype (MaRg ). Biofilm formation, prolonged intracellular survival, and colony variant diversity can each contribute to the persistence of M. abscessus and other bacterial pathogens in chronic pulmonary diseases...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29276785/mycobacterium-abscessus-disease-in-lung-transplant-recipients-diagnosis-and-management
#5
Satish Chandrashekaran, Patricio Escalante, Cassie C Kennedy
Mycobacterium abscessus complex (MAbsC ) disease in lung transplant recipients is increasingly being recognized as an important cause of graft function decline and suboptimal outcomes. Lung transplant recipients appear to be at the highest risk of MAbsC among solid organ transplant recipients, as they have more intense immunosuppression, and the organisms preferentially inhabit the lungs. MAbsC is the most resistant species of rapidly growing mycobacteria and difficult to treat, causing considerable mortality and morbidity in immunocompetent and immunosuppressed patients...
December 2017: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://www.readbyqxmd.com/read/29273829/isolated-subcutaneous-nontuberculous-mycobacterial-infection-a-rare-case-initially-mischaracterized-as-a-soft-tissue-malignancy
#6
Hee Young Choi, Min Hee Lee, Jong-Seok Lee, In Hye Song, Kyung-Ja Cho
The occurrence of nontuberculous mycobacterial (NTM) infection is rare, and the involvement of the musculoskeletal system is even less common. However, the incidence of soft tissue and skin NTM infection is increasing, particularly in patients who undergo injections and minor surgical procedures. Given the non-specific clinical manifestations of NTM infection, the lack of knowledge among physicians regarding this rare infection could lead to inaccurate and delayed diagnosis. Herein, we present a case of an isolated subcutaneous NTM infection caused by Mycobacterium abscessus in the upper back of an immunocompetent 68-year-old woman...
December 22, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29245262/acute-postcataract-endophthalmitis-at-a-referral-center-in-northern-taiwan-causative-organisms-clinical-features-and-visual-acuity-outcomes-after-treatment-a-retrospective-cohort-study
#7
Yi-Hao Chen, Jiann-Torng Chen, Ming-Cheng Tai, Yu-Ching Chou, Ching-Long Chen
Acute-onset endophthalmitis after cataract surgery is a rare but serious complication. In this study, we identified the clinical profile of acute-onset endophthalmitis after cataract surgery using a retrospective review between January 1, 2009 and December 31, 2015 at a referral center in northern Taiwan. Twenty-five eyes of 25 patients with endophthalmitis were included; 60% were male. The mean age at diagnosis was 70.44 ± 1.66 years. The right eye was affected in 44% of patients. The mean time of cataract surgery to hospital was 12...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29241819/cyclophostin-and-cyclipostins-analogs-new-promising-molecules-to-treat-mycobacterial-related-diseases
#8
Phuong Chi Nguyen, Abdeldjalil Madani, Pierre Santucci, Benjamin P Martin, Rishi R Paudel, Sandrine Delattre, Jean-Louis Herrmann, Christopher D Spilling, Laurent Kremer, Stéphane Canaan, Jean-François Cavalier
The progression of mycobacterial diseases requires the development of new therapeutics. Here, we evaluated the efficacy and selectivity of a panel of Cyclophostin and Cyclipostins analogs (CyCs) against various bacteria and mycobacteria. The activity of these 26 CyCs was first assayed using the agar plate method. Compounds exhibiting a 50-100% growth inhibition rate were then selected to determine their MIC using the REMA assay. The best drug candidate was further tested against mycobacterial clinical isolates and bacteria responsible for nosocomial infections...
December 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29234594/successful-use-of-linezolid-for-refractory-mycobacterium-abcessus-infection-a-case-report
#9
Teppei Inoue, Akihito Tsunoda, Eriko Nishimoto, Kohei Nishida, Yuka Komatsubara, Rintaro Onoe, Junko Saji, Masamichi Mineshita
A 51-year-old male patient was receiving treatment for Mycobacterium abscessus infection for approximately 10 years. However, as his condition gradually progressed to type II respiratory insufficiency, he was referred to our hospital, which was near his home. Computed tomography on his first visit revealed an abscess in the right lower lobe. Because respiratory insufficiency was evident, he was admitted the same day. We began treatment with meropenem, amikacin, and clarithromycin, but his symptoms did not improve...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29227218/association-between-sequevar-and-antibiotic-treatment-outcome-in-patients-with-mycobacterium-abscessus-complex-infections-in-japan
#10
Shiomi Yoshida, Kazunari Tsuyuguchi, Takehiko Kobayashi, Motohisa Tomita, Yoshikazu Inoue, Seiji Hayashi, Katsuhiro Suzuki
PURPOSE: Macrolide susceptibility differs between subspecies in the Mycobacterium abscessus complex, likely due to differences in erm(41) sequevars. Patients with M. abscessus complex infection generally show poor clinical outcomes in response to antibiotic treatment. Here, the association between genotype and treatment outcome was investigated. METHODOLOGY: We collected 69 isolates from 35 patients with non-cystic fibrosis bronchiectasis: 24 had M. abscessus complex lung disease and non-cystic fibrosis bronchiectasis, and 11 were colonized...
December 11, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29217419/in-vitro-activity-of-tedizolid-against-the-mycobacterium-abscessus-complex
#11
Fabrice Compain, Daria Soroka, Beate Heym, Jean-Louis Gaillard, Jean-Louis Herrmann, Delphine Dorchène, Michel Arthur, Vincent Dubée
Infections due to Mycobacterium abscessus carry a poor prognosis since this rapidly growing mycobacterium is intrinsically resistant to most antibiotics. Here, we evaluate the in vitro activity of the new oxazolidinone tedizolid against a collection of 44M. abscessus clinical isolates. The MIC50s and MIC90s of tedizolid (2 and 8μg/mL, respectively) were 2- to 16-fold lower than those of linezolid. There was no difference between the 3M. abscessus subspecies. Time-kill assays did not show any bactericidal activity at 4- and 8-fold the MIC...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29207758/mycobacterium-fortuitum-infection-at-umbilical-hernioplasty-site
#12
Bharti Chogtu, Daliparty Vasudev Malik, Rahul Magazine, Vishnu Prasad Shenoy
Non Tuberculous Mycobacteria (NTM) are a group of rapidly growing mycobacteria and are generally considered to be of low virulence. Of late, there has been an increase in incidence of infections due to these organisms. Among them, Mycobacterium fortuitum, M. chelonae and M. abscessus are the common species which have been identified. Though they are occasionally implicated in pulmonary infections, NTM are very commonly associated with cutaneous infections, especially surgical site infections. Identification of NTM infection at such sites should be suspected when there is delayed healing of the wound...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205119/activity-of-rifabutin-and-hemi-synthetic-derivatives-against-mycobacterium-abscessus
#13
Ivy B Ramis, Ricardo Figueiredo, Daniela F Ramos, Priscila C B Halicki, Andrea von Groll, Miguel Viveiros, Maria do Ceu Costa, Pedro E A da Silva
BACKGROUND: Mycobacterium abscessus causes a wide range of clinical diseases that are difficult to treat. This microorganism is resistant not only to the classical antituberculosis agents but also to most of the antimicrobials that are currently available, resulting in limited therapeutic options and treatment failure. This scenario stresses the need to search for new drugs with activity against M. abscessus. OBJECTIVE: To evaluate in vitro the antimycobacterial activity and cytotoxicity of rifabutin (RFB 1) and ten derivatives (2-11) against M...
December 3, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29197331/genotyping-and-drug-susceptibility-testing-of-mycobacterial-isolates-from-population-based-tuberculosis-prevalence-survey-in-ghana
#14
Kennedy Kwasi Addo, Samuel Ofori Addo, Gloria Ivy Mensah, Lydia Mosi, Frank Adae Bonsu
BACKGROUND: Mycobacterium tuberculosis complex (MTBC) and Non-tuberculosis Mycobacterium (NTM) infections differ clinically, making rapid identification and drug susceptibility testing (DST) very critical for infection control and drug therapy. This study aims to use World Health Organization (WHO) approved line probe assay (LPA) to differentiate mycobacterial isolates obtained from tuberculosis (TB) prevalence survey in Ghana and to determine their drug resistance patterns. METHODS: A retrospective study was conducted whereby a total of 361 mycobacterial isolates were differentiated and their drug resistance patterns determined using GenoType Mycobacterium Assays: MTBC and CM/AS for differentiating MTBC and NTM as well MTBDRplus and NTM-DR for DST of MTBC and NTM respectively...
December 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29193368/curcumin-an-antibiotic-resistance-breaker-against-a-multiresistant-clinical-isolate-of-mycobacterium-abscessus
#15
Emanuela Marini, Mara Di Giulio, Gloria Magi, Silvia Di Lodovico, Maria Enrica Cimarelli, Andrea Brenciani, Antonia Nostro, Luigina Cellini, Bruna Facinelli
Curcumin, a phenolic compound extracted from Curcuma longa, exerts multiple pharmacological effects, including an antimicrobial action. Mycobacterium abscessus, an environmental, nontuberculous, rapidly growing mycobacterium, is an emerging human pathogen causing serious lung infections and one of the most difficult to treat, due to its multidrug resistance and biofilm-forming ability. We wanted to evaluate the antimicrobial and antivirulence activity of curcumin and its ability to synergize with antibiotics against a clinical M...
November 29, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29190796/risk-factors-for-the-development-of-chronic-pulmonary-aspergillosis-in-patients-with-nontuberculous-mycobacterial-lung-disease
#16
Byung Woo Jhun, Woo Jin Jung, Na Young Hwang, Hye Yun Park, Kyeongman Jeon, Eun-Suk Kang, Won-Jung Koh
Nontuberculous mycobacterial lung disease (NTM-LD) is increasingly recognized as an important predisposing condition for the development of chronic pulmonary aspergillosis (CPA), but there are limited data on the risk factors for CPA development in NTM-LD patients. We reviewed the medical records of 566 patients who, at the time of diagnosis of NTM-LD, did not have CPA and who received ≥12 months of treatment for NTM-LD between January 2010 and June 2015. Of these patients, 41 (7.2%) developed CPA (NTM-CPA group), whereas the remaining 525 patients did not develop CPA (NTM group)...
2017: PloS One
https://www.readbyqxmd.com/read/29176967/reporter-based-assays-for-high-throughput-drug-screening-against-mycobacterium-abscessus
#17
Rashmi Gupta, Mandy Netherton, Thomas F Byrd, Kyle H Rohde
Mycobacterium abscessus is a non-tuberculous mycobacterium that causes pulmonary and non-pulmonary infections. M. abscessus is resistant to many chemotherapeutic agents and the current treatment options show poor clinical outcomes. Thus, there is a dire need to find new antimicrobials effective at killing M. abscessus. Screening drug libraries to identify potential antimicrobials has been impeded by the lack of validated HTS assays for M. abscessus. In this study, we developed two 384-well high-throughput screening assays using fluorescent and bioluminescent reporter strains of M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29176633/epidemiology-and-predictors-of-ntm-pulmonary-infection-in-taiwan-a-retrospective-five-year-multicenter-study
#18
Hung-Ling Huang, Meng-Hsuan Cheng, Po-Liang Lu, Chin-Chung Shu, Jann-Yuan Wang, Jann-Tay Wang, Inn-Wen Chong, Li-Na Lee
Multicenter, longitudinal studies on nontuberculous mycobacteria (NTM) pulmonary infection (PI) are lacking. This study provides a 5-year epidemiological overview of NTM-PI in Taiwan and investigated its predictors. The clinical relevance of each respiratory NTM isolate in six hospitals between 2008 and 2014 was determined according to current guidelines. Recurrent episodes were judged by serial bacteriological results. New episodes of NTM-PI and pulmonary colonization (PC) occurring since 2010 were analyzed...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29173447/clinical-characteristics-and-treatment-outcomes-of-pleural-effusions-in-patients-with-nontuberculous-mycobacterial-disease
#19
Sojung Park, Kyung-Wook Jo, Sang-Do Lee, Woo Sung Kim, Tae Sun Shim
BACKGROUND: The incidence of nontuberculous mycobacterial (NTM) infection has increased over the last 10 years. However, the clinical characteristics and treatment outcomes of patients with NTM pleuritis have not been well defined. METHODS: Patients with pleural effusion and NTM lung disease diagnosed between 1997 and 2013 were enrolled and their medical records were reviewed retrospectively. The subjects were divided into definite (n = 9, NTM isolated from the pleura or pleural effusion) and possible (n = 5, NTM lung disease with pleural effusion and improvement of effusion after anti-NTM treatment) groups...
December 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29171453/antibiotic-resistance-in-mycobacterium-abscessus-and-mycobacterium-fortuitum-isolates-from-malaysian-patients
#20
Sharmilla Devi Jayasingam, Thaw Zin, Yun Fong Ngeow
BACKGROUND: Rapidly growing mycobacterial species (RGM) are increasingly being recognized as the cause of various superficial and deep infections in humans. Two of the species most frequently isolated from clinical specimens are Mycobacterium abscessus and Mycobacterium fortuitum. Both species are associated with antibiotic resistances that may complicate therapy. This paper describes the pattern of resistance to five antibiotics commonly prescribed for RGM infections, in M. abscessus and M...
October 2017: International Journal of Mycobacteriology
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