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mycobacterium abscessus

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https://www.readbyqxmd.com/read/29774836/pulmonary-infections-with-nontuberculous-mycobacteria-catalonia-spain-1994-2014
#1
Miguel Santin, Irene Barrabeig, Pierre Malchair, Lucia Gonzalez-Luquero, Miguel A Benitez, Josefina Sabria, Merce Palau-Benavent, Concepcion Cañete, Joan A Lloret-Queraltó, Maria D Grijota-Camino, Jordi Dorca, Fernando Alcaide
In Spain, systematic reporting of pulmonary infections with nontuberculous mycobacteria is not mandatory. Therefore, to determine trends, we retrospectively identified cases for January 1994-December 2014 in Catalonia. Over the 21 years, prevalence increased and was associated with being male. Mycobacterium avium complex and M. abscessus prevalence increased; M. kansasii prevalence decreased.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#2
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772918/cutaneous-nontuberculous-mycobacterial-infections-in-alberta-canada-an-epidemiologic-study-and-review
#3
Megan A Sander, Judith L Isaac-Renton, Gregory J Tyrrell
BACKGROUND: Cutaneous infections caused by nontuberculous mycobacteria (NTM) occur infrequently. Nonetheless, the incidence of NTM infections is reported to be increasing. In Canada, cutaneous NTM infections have not been well described. OBJECTIVES: A database review from 2006 to 2016 was done to assess species frequency, incidence, and trends of the most common cutaneous NTMs in the province of Alberta, Canada. We also reviewed major diagnostic and epidemiologic aspects of NTM cutaneous infections with a focus on Mycobacterium marinum...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29760147/rifabutin-acts-in-synergy-and-is-bactericidal-with-frontline-mycobacterium-abscessus-antibiotics-clarithromycin-and-tigecycline-suggesting-a-potent-treatment-combination
#4
Mark Pryjma, Ján Burian, Charles J Thompson
Mycobacterium abscessus (MAB ) is a rapidly emerging mycobacterial pathogen causing dangerous pulmonary infections. Because these bacteria are intrinsically multidrug resistant, treatment options are limited and have questionable efficacy. The current treatment regimen relies on a combination of antibiotics including clarithromycin paired with amikacin and either imipenem or cefoxitin. Tigecycline may be added when triple therapy is ineffective. We initially screened a library containing the majority of clinically available antibiotics for anti- MAB activity...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29760127/-in-vitro-activity-of-clofazimine-against-non-tuberculous-mycobacteriaisolated-in-beijing-china
#5
Jingjing Luo, Xia Yu, Guanglu Jiang, Yuhong Fu, Fengmin Huo, Yifeng Ma, Fen Wang, Yuanyuan Shang, Qian Liang, Yi Xue, Hairong Huang
Due to the natural resistance of non-tuberculous mycobacteria(NTM) to lots of antibiotics,treatment of diseases caused by NTM is often long-termed but less successful.The main goal of this study was to evaluate the in vitro susceptibility to clofazimine of 209 isolates consisting of different NTM species isolated in Beijing,China. Furthermore,47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) species and 17 slowly growing mycobacterium(SGM) species.The potential molecular mechanism contributing to clofazimine resistance of NTM was investigated as well...
May 14, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29754381/non-tuberculous-mycobacterial-infections-in-thoracic-transplant-candidates-and-recipients
#6
REVIEW
Mana Rao, Fernanda P Silveira
PURPOSE OF REVIEW: To review and discuss the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of non-tuberculous mycobacteria (NTM) in thoracic transplantation. RECENT FINDINGS: Non-tuberculous mycobacteria are ubiquitous but are an uncommon cause of disease after solid organ transplantation. The incidence of infection is higher in thoracic transplant recipients than in abdominal transplant recipients, with most cases seen after lung transplantation...
May 12, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29712660/novel-mutations-associated-with-clofazimine-resistance-in-mycobacterium-abscessus
#7
Yuanyuan Chen, Jiazhen Chen, Shuo Zhang, Wanliang Shi, Wenhong Zhang, Min Zhu, Ying Zhang
Mycobacterium abscessus ( Mab ) is a major non-tuberculous mycobacterial (NTM) pathogen responsible for about 80% of all pulmonary infections caused by rapidly growing mycobacteria. Clofazimine is an effective drug active against Mab , but the mechanism of resistance to clofazimine in Mab is unknown. To investigate the molecular basis of clofazimine resistance in Mab. We isolated 29 Mab mutants resistant to clofazimine, and subjected them to whole genome sequencing to identify possible mutations associated with clofazimine resistance...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29712658/determination-of-mic-distribution-and-mechanisms-of-decreased-susceptibility-to-bedaquiline-among-clinical-isolates-of-mycobacterium-abscessus
#8
Bing Li, Meiping Ye, Qi Guo, Zhemin Zhang, Shiyi Yang, Wei Ma, Fangyou Yu, Haiqing Chu
Chemotherapeutic options are very limited against Mycobacterium abscessus infections. Bedaquiline, a new anti-tuberculosis drug, is effective for the treatment of multidrug-resistant TB. However, little data is available on bedaquiline in treating M. abscessus infections. In this study, we reported the in vitro susceptibility profile of M. abscessus clinical isolates to bedaquiline and investigated the potential molecular mechanisms of decreased susceptibility. A total of 197 M. abscessus clinical isolates were collected from sputum and bronchoalveolar fluid of patients with lung infections...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29698397/pathogen-box-screening-for-hit-identification-against-mycobacterium-abscessus
#9
Jinsun Jeong, Guehye Kim, Cheol Moon, Hyun Jung Kim, Tae Ho Kim, Jichan Jang
Mycobacterium abscessus is a rapidly growing life-threatening mycobacterium with multiple drug-resistance mechanisms. However, there is no official regimen for M. abscessus therapy. In this study, we screened the Pathogen Box, which contains 400 drug-like molecules active against neglected diseases, to identify active molecules targeting Mycobacterium abscessus using resazurin live/dead assays. In this screening assay, the Z-factor was 0.7, as an indicator of the statistical confidence of the assay. A cut-off of 80% growth inhibition in the screening resulted in the identification of four different compounds at a single concentration (20 μM)...
2018: PloS One
https://www.readbyqxmd.com/read/29687315/incidental-intraoperative-diagnosis-of-mycobacterium-abscessus-meningeal-infection-a-case-report-and-review-of-the-literature
#10
REVIEW
Francesca Giovannenze, Vito Stifano, Giancarlo Scoppettuolo, Fernando Damiano, Federico Pallavicini, Giovanni Delogu, Ivana Palucci, Alessandro Rapisarda, Cosimo Sturdà, Angelo Pompucci
PURPOSE: Mycobacterium abscessus, and rapidly growing mycobacteria in general, are rare but increasing causes of central nervous system (CNS) infections. The aim of this study is to highlight the importance of considering these microorganism in the differential diagnosis of CNS infections, obtaining a prompt diagnosis, and improving clinical outcomes. METHODS: Case report and literature review. RESULTS: We report a case of meningeal infection in a patient who underwent decompressive craniectomy after a craniofacial trauma...
April 23, 2018: Infection
https://www.readbyqxmd.com/read/29675007/mechanistic-and-structural-insights-into-the-unique-tetr-dependent-regulation-of-a-drug-efflux-pump-in-mycobacterium-abscessus
#11
Matthias Richard, Ana Victoria Gutiérrez, Albertus J Viljoen, Eric Ghigo, Mickael Blaise, Laurent Kremer
Mycobacterium abscessus is an emerging human pathogen causing severe pulmonary infections and is refractory to standard antibiotherapy, yet few drug resistance mechanisms have been reported in this organism. Recently, mutations in MAB_4384 leading to up-regulation of the MmpS5/MmpL5 efflux pump were linked to increased resistance to thiacetazone derivatives. Herein, the DNA-binding activity of MAB_4384 was investigated by electrophoretic mobility shift assays using the palindromic sequence IRS5/L5 located upstream of mmpS5/mmpL5 ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29672589/neutrophil-killing-of-mycobacterium-abscessus-by-intra-and-extracellular-mechanisms
#12
Kenneth C Malcolm, Silvia M Caceres, Kerstin Pohl, Katie R Poch, Audrey Bernut, Laurent Kremer, Donna L Bratton, Jean-Louis Herrmann, Jerry A Nick
Mycobacterium abscessus, a rapidly growing nontuberculous mycobacterium, are increasingly present in soft tissue infections and chronic lung diseases, including cystic fibrosis, and infections are characterized by growth in neutrophil-rich environments. M. abscessus is observed as two distinct smooth and rough morphotypes. The environmental smooth morphotype initiates infection and has a relatively limited ability to activate neutrophils. The rough morphotype has increased virulence and immunogenicity. However, the neutrophil response to the rough morphotype has not been explored...
2018: PloS One
https://www.readbyqxmd.com/read/29661870/amikacin-inhalation-as-salvage-therapy-for-refractory-nontuberculous-mycobacterial-lung-disease
#13
Byung Woo Jhun, Bumhee Yang, Seong Mi Moon, Hyun Lee, Hye Yun Park, Kyeongman Jeon, O Jung Kwon, Jungmin Ahn, Il Joon Moon, Sung Jae Shin, Charles L Daley, Won-Jung Koh
Although guidelines recommend amikacin (AMK) inhalation therapy for difficult-to-treat nontuberculous mycobacterial lung disease (NTM-LD), data are limited regarding the safety and clinical efficacy of this salvage therapy. We retrospectively evaluated treatment outcomes of 77 patients with refractory NTM-LD caused by Mycobacterium abscessus complex (MABC) or M. avium complex (MAC) who initiated AMK inhalation therapy between February 2015 and June 2016. MABC was the most common etiology (n = 48, 62%), followed by MAC (n = 20, 26%) and mixed infections (n = 9, 12%)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29649431/diagnosis-and-management-of-children-with-mycobacterium-abscessus-infections-in-the-head-and-neck
#14
Justine Moe, Roy Rajan, Shelley Caltharp, Shelly Abramowicz
PURPOSE: Controversy exists regarding the most appropriate treatment strategy for children with nontuberculous mycobacterial (NTM) cervical lymphadenitis. Mycobacterium abscessus (MAB) is an uncommon cause of NTM cervical lymphadenitis. The purpose of the present study was to evaluate diagnosis, management, and treatment outcomes in children with MAB-associated cervical lymphadenitis resulting from a pulpotomy. MATERIALS AND METHODS: This was a retrospective chart review of children with NTM lymphadenitis of the head and neck caused by MAB treated at Children's Healthcare of Atlanta hospitals (Atlanta, GA)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29648588/influence-of-three-dimensional-lung-epithelial-cells-and-interspecies-interactions-on-antibiotic-efficacy-against-mycobacterium-abscessus-and-pseudomonas-aeruginosa
#15
Graciela Rodríguez-Sevilla, Charlotte Rigauts, Eva Vandeplassche, Lisa Ostyn, Ignacio Mahíllo-Fernández, Jaime Esteban, Concepción Pérez-Jorge Peremarch, Tom Coenye, Aurélie Crabbé
Mycobacterium abscessus lung infection is a major health problem for cystic fibrosis (CF) patients. Understanding the in vivo factors that influence the outcome of therapy may help addressing the poor correlation between in vitro and in vivo antibiotic efficacy. We evaluated the influence of interspecies interactions and lung epithelial cells on antibiotic efficacy. Therefore, single and dual species biofilms of M. abscessus and a major CF pathogen (Pseudomonas aeruginosa) were cultured on a plastic surface or on in vivo-like three-dimensional (3-D) lung epithelial cells, and the activity of antibiotics (colistin, amikacin, clarithromycin, ceftazidime) in inhibiting biofilm formation was evaluated...
April 10, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29643203/evaluation-of-the-vitek-ms-v3-0-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-system-for-identification-of-mycobacterium-and-nocardia-species
#16
Barbara A Body, Melodie A Beard, E Susan Slechta, Kimberly E Hanson, Adam P Barker, N Esther Babady, Tracy McMillen, Yi-Wei Tang, Barbara A Brown-Elliott, Elena Iakhiaeva, Ravikiran Vasireddy, Sruthi Vasireddy, Terry Smith, Richard J Wallace, S Turner, L Curtis, Susan Butler-Wu, Jenna Rychert
This multi-center study was designed to assess the accuracy and reproducibility of the VITEK MS v3.0 matrix-assisted laser desorption ionization--time of flight (MALDI-TOF) mass spectrometry system for identification of Mycobacterium and Nocardia species compared to DNA sequencing. A total of 963 clinical isolates representing 51 taxa were evaluated. In all, 663 isolates were correctly identified to the species level (69%) with another 231 (24%) correctly identified to the complex or group level. Fifty-five isolates (6%) could not be identified despite repeat testing...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29626567/evaluation-of-the-intracellular-activity-of-drugs-against-mycobacterium-abscessus-using-a-thp-1-macrophage-model
#17
Carmen Amelia Molina-Torres, Lorena Taméz-Peña, Jorge Castro-Garza, Jorge Ocampo-Candiani, Lucio Vera-Cabrera
We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level.
April 4, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29601108/synthesis-of-avibactam-derivatives-and-activity-on-%C3%AE-lactamases-and-peptidoglycan-biosynthesis-enzymes-of-mycobacteria
#18
Zainab Edoo, Laura Iannazzo, Fabrice Compain, Inès Li de la Sierra Gallay, Herman van Tilbeurgh, Matthieu Fonvielle, Flavie Bouchet, Eva Le Run, Jean-Luc Mainardi, Michel Arthur, Mélanie Ethève-Quelquejeu, Jean-Emmanuel Hugonnet
There is a renewed interest for β-lactams for treating infections due to Mycobacterium tuberculosis and M. abscessus since their β-lactamases are inhibited by classical (clavulanate) or new generation (avibactam) inhibitors, respectively. Here, we report access to an azido derivative of the diazabicyclooctane (DBO) scaffold of avibactam for functionalization by the Huisgen-Sharpless cycloaddition reaction. The amoxicillin-DBO combinations were active indicating that the triazole ring is compatible with drug penetration (minimal inhibitory concentration of 16 µg/ml for both species)...
March 30, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29594066/a-simple-and-rapid-gene-disruption-strategy-in-mycobacterium-abscessus-on-the-design-and-application-of-glycopeptidolipid-mutants
#19
Albertus Viljoen, Ana Victoria Gutiérrez, Christian Dupont, Eric Ghigo, Laurent Kremer
Little is known about the disease-causing genetic determinants that are used by Mycobacterium abscessus , increasingly acknowledged as an important emerging pathogen, notably in cystic fibrosis. The presence or absence of surface exposed glycopeptidolipids (GPL) conditions the smooth (S) or rough (R) M. abscessus subsp. abscessus ( M. abscessus ) variants, respectively, which are characterized by distinct infective programs. However, only a handful of successful gene knock-out and conditional mutants have been reported in M...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29564361/positive-effect-of-liposomal-amikacin-for-inhalation-on-mycobacterium-abcessus-in-cystic-fibrosis-patients
#20
Davide Caimmi, Nicolas Martocq, Delphine Trioleyre, Catherine Guinet, Sylvain Godreuil, Thomas Daniel, Raphael Chiron
Mycobacterium abscessus is difficult to eradicate. At the Montpellier CF Center, we prescribed liposomal amikacin for inhalation to 5 patients with M abscessus infection. The 3 patients who completed the treatment did not have any respiratory exacerbation, showed negative cultures for M abscessus in their sputum, and stabilized their spirometric functions.
March 2018: Open Forum Infectious Diseases
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