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mycobacterium abscessus

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https://www.readbyqxmd.com/read/28224727/molecular-identification-and-distribution-of-non-tuberculous-mycobacteria-isolated-from-clinical-specimens-by-pcr-sequencing-method-in-west-of-iran
#1
Mahsa Dastranj, Abbas Farahani, Abdolrazagh Hashemi Shahraki, Sara Atashi, Parviz Mohajeri
BACKGROUND AND AIMS: Infections by Non-tuberculous Mycobacteria (NTM) has rapidly increased in recent years, due to high infection rates related to the populations at risk like immunocompromised individuals, patients predisposed by prior pulmonary. The aim of this study was to investigate the presence of NTM in clinical samples and genetic diversity using 16S rRNA and rpoB sequence analysis. METHODS: A cross-sectional study was conducted on 45 diverse isolates collected from sputum in two years 2014-2015 using standard decontamination procedure...
February 22, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28221128/epidemiology-of-nontuberculous-mycobacterial-lung-disease-and-tuberculosis-hawaii-usa
#2
Jennifer Adjemian, Timothy B Frankland, Yihe G Daida, Jennifer R Honda, Kenneth N Olivier, Adrian Zelazny, Stacey Honda, D Rebecca Prevots
Previous studies found Hawaiians and Asian-Americans/Pacific Islanders to be independently at increased risk for nontuberculous mycobacterial pulmonary disease (NTMPD) and tuberculosis (TB). To better understand NTM infection and TB risk patterns in Hawaii, USA, we evaluated data on a cohort of patients in Hawaii for 2005-2013. Period prevalence of NTMPD was highest among Japanese, Chinese, and Vietnamese patients (>300/100,000 persons) and lowest among Native Hawaiians and Other Pacific Islanders (50/100,000)...
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28199133/endobronchial-lesions-of-mycobacterium-abscessus-infection-in-an-immunocompromised-patient
#3
Keigo Saeki, Satoshi Watanabe, Yuko Waseda, Kazuo Kasahara
No abstract text is available yet for this article.
February 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28194371/non-tuberculous-mycobacteria-in-south-african-wildlife-neglected-pathogens-and-potential-impediments-for-bovine-tuberculosis-diagnosis
#4
Nomakorinte Gcebe, Tiny M Hlokwe
Non-tuberculous mycobacteria (NTM) are not only emerging and opportunistic pathogens of both humans and animals, but from a veterinary point of view some species induce cross-reactive immune responses that hamper the diagnosis of bovine tuberculosis (bTB) in both livestock and wildlife. Little information is available about NTM species circulating in wildlife species of South Africa. In this study, we determined the diversity of NTM isolated from wildlife species from South Africa as well as Botswana. Thirty known NTM species and subspecies, as well as unidentified NTM, and NTM closely related to Mycobacterium goodii/Mycobacterium smegmatis were identified from 102 isolates cultured between the years 1998 and 2010, using a combination of molecular assays viz PCR and sequencing of different Mycobacterial house-keeping genes as well as single nucleotide polymorphism (SNP) analysis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28190461/detection-of-mycobacterium-chelonae-mycobacterium-abscessus-group-and-mycobacterium-fortuitum-complex-by-a-multiplex-real-time-pcr-directly-from-clinical-samples-using-the-bd-max-system
#5
Talita T Rocchetti, Suzane Silbert, Alicia Gostnell, Carly Kubasek, Antonio C Campos Pignatari, Raymond Widen
A new multiplex PCR test was designed to detect Mycobacterium chelonae, Mycobacterium abscessus group, and Mycobacterium fortuitum complex on the BD MAX System. A total of 197 clinical samples previously submitted for mycobacterial culture were tested using the new protocol. Samples were first treated with proteinase K, and then each sample was inoculated into the BD MAX Sample Buffer Tube. Extraction and multiplex PCR were performed by the BD MAX System, using the BD MAX ExK TNA-3 extraction kit and BD TNA Master Mix, along with specific in-house designed primers and probes for each target...
March 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28188830/in-vitro-activity-of-clarithromycin-in-combination-with-other-antimicrobial-agents-against-mycobacterium-abscessus-and-mycobacterium-massiliense
#6
Zhijian Zhang, Jie Lu, Min Liu, Yufeng Wang, Yanlin Zhao, Yu Pang
Macrolides, especially clarithromycin (CLA), remain the cornerstone of therapy for Mycobacterium abscessus complex infections. The purpose of this study was to gather results from in vitro drug susceptibility testing of M. abscessus and Mycobacterium massiliense for the combination of CLA with various other agents, including linezolid (LZD), moxifloxacin (MOX), amikacin (AMK) and tigecycline (TGC). A total of 40 M. abscessus complex isolates were studied, comprising 20 M. abscessus and 20 M. massiliense strains...
February 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28180105/mixed-infection-of-mycobacterium-abscessus-subsp-abscessus-and-mycobacterium-tuberculosis-in-the-lung
#7
Sungmin Sohn, Sungho Wang, Hyejin Shi, Sungrock Park, Sangki Lee, Kyoung Taek Park
A mixed infection of Mycobacterium abscessus subsp. abscessus (Mab) and Mycobacterium tuberculosis (MTB) in the lung is an unusual clinical manifestation and has not yet been reported. A 61-year-old woman had been treated for Mab lung disease and concomitant pneumonia, and was diagnosed with pulmonary tuberculosis (PTB). Despite both anti-PTB and anti-Mab therapy, her entire left lung was destroyed and collapsed. She underwent left pneumonectomy and received medical therapy. We were able to successfully treat her mixed infection by pneumonectomy followed by inhaled amikacin therapy...
February 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28180066/case-report-on-pulmonary-disease-due-to-coinfection-of-mycobacterium-tuberculosis-and-mycobacterium-abscessus-difficulty-in-diagnosis
#8
Celestine Ishiekwene, Mala Subran, Monica Ghitan, Margaret Kuhn-Basti, Edward Chapnick, Yu Shia Lin
Mycobacterium abscessus, which is ubiquitous environmental organism, is more likely to cause pulmonary infection in the presence underlying lung disease and immunosuppression. We report a case of pulmonary disease due to coinfection of Mycobacterium tuberculosis (MTB) and Mycobacterium abscessus (M. abscessus) in an immunocompetent patient without underlying lung disease. Healthcare professionals should be aware of co-infection with MTB and M. abscessus, and treatment should be based on clinical suspicion and/or epidemiological circumstances...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28157481/a-case-of-mycobacterium-abscessus-subsp-massiliense-lung-disease-complicated-by-lipoid-pneumonia
#9
Takehiko Kobayashi, Kazunari Tsuyuguchi, Shiomi Yoshida, Yu Kurahara, Taisuke Tsuji, Keiko Nakao, Yumiko Sasaki, Seiji Hayashi, Yoshikazu Inoue, Katsuhiro Suzuki
No abstract text is available yet for this article.
January 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28128073/nontuberculous-mycobacteria-overview
#10
Won-Jung Koh
Nontuberculous mycobacteria (NTM) are emerging pathogens that affect both immunocompromised and immunocompetent patients. The development of molecular methods has allowed the characterization of new species and the identification of NTM to the precise species and subspecies levels. The incidence and prevalence of NTM lung disease are increasing worldwide, and this syndrome accounts for the majority of clinical cases of NTM disease. Common causative organisms of pulmonary infection are the slowly growing mycobacteria Mycobacterium avium complex and Mycobacterium kansasii and the rapidly growing mycobacteria, including Mycobacterium abscessus complex...
January 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28108242/evaluation-of-the-antimicrobial-activity-of-the-mastoparan-polybia-mpii-isolated-from-venom-of-the-social-wasp-pseudopolybia-vespiceps-testacea-vespidae-hymenoptera
#11
Juliana C Silva, Lázaro M Neto, Rogério C Neves, Jaqueline C Gonçalves, Monalisa M Trentini, Ricardo Mucury-Filho, Karina S Smidt, Isabel C Fensterseifer, Osmar N Silva, Lilian D Lima, Patricia B Clissa, Nathália Vilela, Fernanda Guilhelmelli, Luciano P Silva, Marisa Rangel, André Kipnis, Ildinete Silva-Pereira, Octavio L Franco, Ana P Junqueira-Kipnis, Anamelia L Bocca, Márcia R Mortari
Mastoparans, a class of peptides found in wasp venom, have significant effects following a sting as well as useful applications in clinical practice. Among these is their potential use in the control of micro-organisms that cause infectious diseases with a significant impact on society. Thus, the present study describes the isolation and identification of a mastoparan peptide from the venom of the social wasp Pseudopolybia vespiceps and evaluated its antimicrobial profile against bacteria (Staphylococcus aureus and Mycobacterium abscessus subsp...
January 9, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28096157/resistance-to-thiacetazone-derivatives-active-against-mycobacterium-abscessus-involves-mutations-in-the-mmpl5-transcriptional-repressor-mab_4384
#12
Iman Halloum, Albertus Viljoen, Varun Khanna, Derek Craig, Christiane Bouchier, Roland Brosch, Geoffrey Coxon, Laurent Kremer
Available chemotherapeutic options are very limited against Mycobacterium abscessus, which imparts a particular challenge in the treatment of cystic fibrosis (CF) patients infected with this rapid-growing mycobacterium. New drugs are urgently needed against this emerging pathogen, but the discovery of active chemotypes has not been performed intensively. Interestingly, however, the repurposing of thiacetazone (TAC), a drug once used to treat tuberculosis, has increased following the deciphering of its mechanism of action and the detection of significantly more potent analogues...
January 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28096155/inhibition-of-the-%C3%AE-lactamase-blamab-by-avibactam-improves-the-in-vitro-and-in-vivo-efficacy-of-imipenem-against-mycobacterium-abscessus
#13
Anne-Laure Lefebvre, Vincent Le Moigne, Audrey Bernut, Carole Veckerlé, Fabrice Compain, Jean-Louis Herrmann, Laurent Kremer, Michel Arthur, Jean-Luc Mainardi
Mycobacterium abscessus pulmonary infections are treated with a macrolide (clarithromycin or azithromycin), an aminoglycoside (amikacin), and a β-lactam (cefoxitin or imipenem). The triple combination is used without any β-lactamase inhibitor despite production of the broad spectrum β-lactamase BlaMab We determine whether inhibition of BlaMab by avibactam improves the activity of imipenem against M. abscessus. Bactericidal activity of drug combinations was assayed in broth and in human macrophages. The in vivo efficacy of the drugs was tested by monitoring the survival of infected zebrafish embryos...
January 17, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28094581/early-immunopathological-events-in-acute-model-of-mycobacterial-hypersensitivity-pneumonitis-in-mice
#14
Elisabet Johansson, Gregory P Boivin, Jagjit S Yadav
Prolonged exposure to antigens of non-tuberculous mycobacteria species colonizing industrial metalworking fluid (MWF), particularly Mycobacterium immunogenum (MI), has been implicated in chronic forms of hypersensitivity pneumonitis (HP) in machinists based on epidemiology studies and long-term exposure of mouse models. However, a role of short-term acute exposure to these antigens has not been described in the context of acute forms of HP. This study investigated short-term acute exposure of mice to MI cell lysate (or live cell suspension) via oropharyngeal aspiration...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28077517/two-phase-hospital-associated-outbreak-of-mycobacterium-abscessus-investigation-and-mitigation
#15
Arthur W Baker, Sarah S Lewis, Barbara D Alexander, Luke F Chen, Richard J Wallace, Barbara A Brown-Elliott, Pamela J Isaacs, Lisa C Pickett, Chetan B Patel, Peter K Smith, John M Reynolds, Jill Engel, Cameron R Wolfe, Carmelo A Milano, Jacob N Schroder, Robert D Davis, Matthew G Hartwig, Jason E Stout, Nancy Strittholt, Eileen K Maziarz, Jennifer Horan Saullo, Kevin C Hazen, Richard J Walczak, Ravikiran Vasireddy, Sruthi Vasireddy, Celeste M McKnight, Deverick J Anderson, Daniel J Sexton
BACKGROUND: Nontuberculous mycobacteria (NTM) commonly colonize municipal water and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital. METHODS: Case patients had recent hospital exposure and laboratory-confirmed colonization or infection with M. abscessus from January 2013 through December 2015. We conducted a multidisciplinary epidemiologic, field, and laboratory investigation. RESULTS: The incidence rate of M...
January 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28050369/a-case-of-surgical-site-infection-caused-by-mycobacterium-fortuitum-following-herniorrhaphy
#16
N S Madhusudhan, A Malini, Mima Maychet B Sangma
Rapidly Growing Mycobacteria (RGM) are opportunistic pathogens found in the environment. Mycobacterium fortuitum, M. chelonae and M.abscessus are the important human pathogens of this group. They cause wound infections, disseminated cutaneous disease, pulmonary infection in patients with cystic fibrosis or bronchiectasis, bone and joint infections and keratitis. Infections due to these Non-Tuberculous Mycobacteria (NTM) are increasingly reported. Post laparoscopic wound infections, mesh site infections and other surgical site infections due to M...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28043564/trfa1-gene-in-clinical-isolates-of-mycobacterium-tuberculosis
#17
Azam Ahmadi, Mohammad Arjomandzadegan, Masoomeh Saberpoor, Mona Moghadasi
OBJECTIVE/BACKGROUND: The incidence of resistant strains of Mycobacterium tuberculosis (MTB), including multi-drug resistant, extensively drug resistant, or totally drug resistant, is one of the major problems of health policies worldwide. The accumulation of mutations causes multi-drug resistant strains. Mycobacterium abscessus has a plasmid called pMab2401 containing the trfA1 gene in its integron part. The aim of the present study was to investigate the possible existence of the trfA1 gene in clinical strains of MTB for the first time...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043562/identification-of-nontuberculous-mycobacteria-by-high-performance-liquid-chromatography-from-patients-in-tehran
#18
Ali Mirzapour, Ali Nazari Alam, Saeed Z Bostanabadi, Abdolrazagh H Shahraki, Soltan A Ebrahimi, Masoud Yousefi
BACKGROUND/OBJECTIVES: The genus Mycobacterium contains over 140 species comprises pathogenic and nonpathogenic strains. Nontuberculous mycobacteria (NTM) causing clinical disease have become increasingly common and more diverse. Widespread features of NTM infection can make the diagnosis difficult. Precise species-level detection can aid in distinguishing environmental contamination from actual infection and, furthermore, can assist in making a choice of antimicrobial therapy. MATERIALS AND METHODS: Mycolic acids extracted from saponified mycobacterial cells were examined by high performance liquid chromatography (HPLC) in addition to phenotypic tests for the identification of 20 clinical isolates of mycobacteria at Masoud Laboratory during 2014-2015...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28039278/inhibition-of-%C3%AE-lactamases-of-mycobacteria-by-avibactam-and-clavulanate
#19
Daria Soroka, Clément Ourghanlian, Fabrice Compain, Marion Fichini, Vincent Dubée, Jean-Luc Mainardi, Jean-Emmanuel Hugonnet, Michel Arthur
OBJECTIVES: Mycobacterium tuberculosis and Mycobacterium abscessus produce broad-spectrum class A β-lactamases, BlaC and BlaMab, which are inhibited by clavulanate and avibactam, respectively. BlaC differs from BlaMab at Ambler position 132 in the conserved motif SDN (SDG versus SDN, respectively). Here, we investigated whether this polymorphism could account for the inhibition specificity of β-lactamases from slowly and rapidly growing mycobacteria. METHODS: Enzyme kinetics were determined to assess the impact of the substitutions G(132)N in BlaC and N(132)G in BlaMab on β-lactamase inhibition by clavulanate and avibactam...
December 30, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28011609/progression-and-treatment-outcomes-of-lung-disease-caused-by-mycobacterium-abscessus-and-mycobacterium-massiliense
#20
Jimyung Park, Jaeyoung Cho, Chang-Hoon Lee, Sung Koo Han, Jae-Joon Yim
BACKGROUND: Mycobacterium abscessus and Mycobacterium massiliense are grouped as the Mycobacterium abscessus complex. The aim of this study was to elucidate the differences between M. abscessus and M. massiliense lung diseases in terms of progression rate, treatment outcome, and the predictors thereof. METHODS: Between 1 January 2006 and 30 June 2015, 56 patients and 54 patients were diagnosed with M. abscessus and M. massiliense lung diseases, respectively. The time to progression requiring treatment and treatment outcomes were compared between the 2 groups of patients, and predictors of progression and sustained culture conversion with treatment were analyzed...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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