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mycobacterium abscessus

Takehiko Kobayashi, Kazunari Tsuyuguchi, Shiomi Yoshida, Yu Kurahara, Naoya Ikegami, Maiko Naito, Shoko Sonobe, Toshiya Maekura, Taisuke Tsuji, Shojiro Minomo, Yoshikazu Inoue, Katsuhiro Suzuki
Background: Among Mycobacterium abscessus complex infections, patients with M. abscessus subsp. abscessus (MAA) lung disease are difficult to treat and no standard therapy has been established. Few reports have investigated the drug susceptibility of these strains. We retrospectively investigated how in vitro drug susceptibility testing (DST) of MAA affects the induction of sputum conversion using pharmacotherapy. Methods: Patients with MAA lung disease diagnosed and treated between 2010 and 2014 at our hospital were enrolled and divided into Group A (sputum conversion without relapse within 1 year) and Group B (persistent positive cultured or negative conversion with relapse)...
January 2018: International Journal of Mycobacteriology
Steven Caskey, John E Moore, Jacqueline C Rendall
Background: Mycobacterium abscessus pulmonary infection has recently emerged as a significant pathogen in patients with cystic fibrosis (CF) and is associated with significant morbidity and accelerated pulmonary decline. There is a paucity of data describing the activity of hospital biocides against this organism. Methods: M. abscessus isolates (n = 13) were recovered from CF and non-CF respiratory specimens. Seven commonly employed hospital biocides with generic ingredients as follows: acetone, propan-2-ol, diethylene glycol, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, chlorine dioxide, 4% chlorhexidine, alcohol, and disodium carbonate, compound with hydrogen peroxide, 10% sodium hypochlorite were assayed for their biocidal activity against M...
January 2018: International Journal of Mycobacteriology
Laura Reisfeld, Cássia Yumi Ikuta, Laura Ippolito, Bruna Silvatti, José Soares Ferreira Neto, José Luiz Catão-Dias, Fernando C W Rosas, José Anselmo Neto, Vera M F da Silva
An adult male Amazonian manatee Trichechus inunguis under human care presented with 3 circular cutaneous lesions on the dorsal aspect of the rostrum and between the nostrils (plenum). Initially these lesions were superficial, hypopigmented, without warmth and non-painful. Microbiological cultures of skin swabs isolated Candida sp. and Pseudomonas aeruginosa, and topical treatment with antiseptic, antifungal, anti-inflammatory and antibiotic medication was instituted. This treatment strategy did not lead to any clinical improvement, and after 6 mo, the lesions progressed to a confluent abscess (5...
March 5, 2018: Diseases of Aquatic Organisms
Radhey S Gupta, Brian Lo, Jeen Son
The genus Mycobacterium contains 188 species including several major human pathogens as well as numerous other environmental species. We report here comprehensive phylogenomics and comparative genomic analyses on 150 genomes of Mycobacterium species to understand their interrelationships. Phylogenetic trees were constructed for the 150 species based on 1941 core proteins for the genus Mycobacterium , 136 core proteins for the phylum Actinobacteria and 8 other conserved proteins. Additionally, the overall genome similarity amongst the Mycobacterium species was determined based on average amino acid identity of the conserved protein families...
2018: Frontiers in Microbiology
Tiffany A Claeys, Richard T Robinson
Nontuberculous mycobacteria (NTM) include species that colonize human epithelia, as well as species that are ubiquitous in soil and aquatic environments. NTM that primarily inhabit soil and aquatic environments include the Mycobacterium avium complex (MAC, M. avium and Mycobacterium intracellulare ) and the Mycobacterium abscessus complex (MABSC, M. abscessus subspecies abscessus , massiliense , and bolletii ), and can be free-living, biofilm-associated, or amoeba-associated. Although NTM are rarely pathogenic in immunocompetent individuals, those who are immunocompromised - due to either an inherited or acquired immunodeficiency - are highly susceptible to NTM infection (NTMI)...
February 26, 2018: Journal of Bacteriology
Qi Guo, Haiqing Chu, Meiping Ye, Zhemin Zhang, Bing Li, Shiyi Yang, Wei Ma, Fangyou Yu
Mycobacterium abscessus accounts for a large proportion of lung disease cases caused by rapidly growing mycobacteria. The association between clarithromycin sensitivity and treatment outcome is clear. However, M. abscessus culture and antibiotic susceptibility testing are time-consuming. Clarithromycin-susceptibility genotyping offers an alternate, rapid approach to predicting the efficacy of clarithromycin-based antibiotic therapy. M. abscessus lung disease patients were divided into two groups based upon the clarithromycin-susceptibility genotype of the organism isolated...
February 26, 2018: Antimicrobial Agents and Chemotherapy
Rashmi Gupta, Carolina R Felix, Matthew P Akerman, Kate J Akerman, Cathryn A Slabber, Wenjie Wang, Jessie Adams, Lindsey N Shaw, Yuk-Ching Tse-Dinh, Orde Q Munro, Kyle H Rohde
Mycobacterium tuberculosis ( Mtb ) and the fast-growing Mycobacterium abscessus ( Mab ) are two important human pathogens causing persistent pulmonary infections that are difficult to cure and require long treatment times. The emergence of drug resistant Mtb strains and the high level of intrinsic resistance of Mab calls for novel drug scaffolds that effectively target both pathogens. In this study, we have evaluated the activity of bis(pyrrolide-imine) gold(III) macrocycles and chelates, originally designed as DNA intercalators capable of targeting human topoisomerase I and II, against Mab and Mtb...
February 26, 2018: Antimicrobial Agents and Chemotherapy
Tatjana Adzic-Vukicevic, Aleksandra Barac, Ana Blanka-Protic, Marija Laban-Lazovic, Bojana Lukovic, Vesna Skodric-Trifunovic, Salvatore Rubino
INTRODUCTION: Non-tuberculous mycobacteria (NTM) are ubiquitous organisms associated with various infections. The aim of the study was to determine the most relevant clinical characteristics of NTM during the 7-year period. METHODOLOGY: A retrospective study of NTM infections was conducted between January 2009 and December 2016. The American Thoracic Society/Infectious Disease Society of America criteria were used to define cases of pulmonary or an extrapulmonary site...
February 23, 2018: Infection
Mark H Adelman, Doreen J Addrizzo-Harris
PURPOSE OF REVIEW: To highlight recent original research and specialty society guidelines regarding the diagnosis and treatment of nontuberculous mycobacterial (NTM) pulmonary disease. RECENT FINDINGS: The prevalence of NTM pulmonary disease has risen in recent years. The prevalence of individual NTM species varies geographically, although Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex (MABC) remain among the most commonly encountered in many regions...
February 20, 2018: Current Opinion in Pulmonary Medicine
Elena Garcia-Zamora, Henar Sanz-Robles, Marta Elosua-Gonzalez, Ximena Rodriguez-Vasquez, Jose Luis Lopez-Estebaranz
(no more than 200 words): In the last few years, the incidence of cutaneous infections caused by nontuberculous mycobacteria is increasing. Since Mycobacterium immunogenum was first described in 2001, few case reports have been described, all of them in the American continent. We report a case with cutaneous infection caused by this newly discovered NTB in Europe.A 65-year-old woman presented with a 3-months history of pruritic lesions on abdomen. Examination revealed erythematous inflammatory papules, pustules, and crusts...
October 15, 2017: Dermatology Online Journal
Ellen Jensen, Stine Holst-Albrechtsen, Kirsten Østergaard Christensen, Lene Birk-Sørensen, Jacob Juel
A 36-year-old Danish woman underwent cosmetic breast surgery in India. Post-operatively, she presented with infection and ulcers under the breasts, and dicloxacillin was administered. The patient did not return for follow-up. Two years later the ulcer under the right breast had not healed, and the patient returned to hospital, where a wound culture was done. The result showed Mycobacterium abscessus. Hence, cephalexin administration was instituted, but the ulcer did not heal, and it was excised. The subsequent healing was rapid...
February 12, 2018: Ugeskrift for Laeger
Maroun Sfeir, Marissa Walsh, Rossana Rosa, Laura Aragon, Sze Yan Liu, Timothy Cleary, Marylee Worley, Corey Frederick, Lilian M Abbo
Background: Infections caused by Mycobacterium abscessus group strains are usually resistant to multiple antimicrobials and challenging to treat worldwide. We describe the risk factors, treatment, and clinical outcomes of patients in 2 large academic medical centers in the United States. Methods: A retrospective cohort study of hospitalized adults with a positive culture for M. abscessus in Miami, Florida (January 1, 2011, to December 31, 2014). Demographics, comorbidities, the source of infection, antimicrobial susceptibilities, and clinical outcomes were analyzed...
February 2018: Open Forum Infectious Diseases
Ryoung Eun Ko, Seong Mi Moon, Soohyun Ahn, Byung Woo Jhun, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Chang Seok Ki, Nam Yong Lee, Won Jung Koh
This study investigated the changes in the major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period in Korea. The increase of number of patients with NTM-LD was primarily due to an increase of Mycobacterium avium complex (MAC) lung disease (LD). Among MAC cases, the proportion of M. avium increased compared with M. intracellulare, whereas the incidence of M. abscessus complex and M. kansasii LD remained relatively stable. The proportion of cases of the nodular bronchiectatic form increased compared with the fibrocavitary form of NTM-LD...
February 19, 2018: Journal of Korean Medical Science
Seoung-Ryoung Choi, Bradley E Britigan, Barbara Switzer, Traci Hoke, David Moran, Prabagaran Narayanasamy
The nontuberculous mycobacterial (NTM) pathogens, M. avium complex (MAC) and M. abscessus, can result in severe pulmonary infections. Current antibiotics confront significant challenges for treatment of these NTM infections due to emerging multidrug-resistance. Thus, development of new antibiotics targeted against these agents is needed. We examined the inhibitory activities of Ga(NO3)3, GaCl3, gallium meso-tetraphenylporphyrin (GaTP) and several derivative nanoparticles (GaNP) against intra- and extracellular M...
February 8, 2018: Molecular Pharmaceutics
Joseph M Banno, Katherine Shield, Krunal Patel, Anupam A Sule
Mycobacterium abscessus is a fast growing, non-tubercular mycobacterium (NTM) found in water. NTM bacteremia is usually seen in immunocompromised patients who have intravascular catheters. Mycobacterium abscessus bacteremia is often caused by exposure to contaminated water supply in hemodialysis units. A 28-year-old female with poorly controlled diabetes mellitus, end stage renal disease (on hemodialysis via Ash catheter), and recurrent deep vein thrombosis presented to the hospital with proximal right leg deep vein thrombosis...
November 27, 2017: Curēus
Raghu Sriram, A K Sahni, Vaibhav L Dudhat, A K Pujahari
Background: Nontuberculous mycobacteria are increasingly being implicated in infections and have become an important cause of health care associated infections. Mycobacterium abscessus, a rapidly growing mycobacteria, is of particular concern as it tends to be resistant to commonly used therapeutic options. Conventional phenotypic methods for speciation of mycobacteria are time consuming, labor intensive and not always reliable. Molecular methods require expertise and are expensive. The study was used to evaluate the use of matrix associated laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) as a means of rapid identification of M...
January 2018: Medical Journal, Armed Forces India
Matthew Schwartz, Stefanie Fisher, Elizabeth Story-Roller, Gyanu Lamichhane, Nicole Parrish
Patients with cystic fibrosis (CF) are at risk for recurrent pulmonary infections due to increased viscosity of airway secretions, leading to persistent colonization with pathogenic bacteria, including nontuberculous mycobacteria (NTM). Extensive antibiotic use for treatment of infections has led to increasing antimicrobial resistance, which is a significant barrier to the treatment of NTMs. We examined the in vitro activity of several antibiotics against a selection of the most drug-resistant clinical isolates of Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium avium complex recovered from CF patients at our institution, as well as paired combinations of antibiotics against a subset of M...
January 25, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Sakhee Kotecha, Olivia C Smibert, Atsuo Doi, Julian Gooi, Orla Morrissey, Miranda Paraskeva, Greg I Snell, David McGiffin
Mycobacterium abscessus infection following lung transplantation has historically been associated with poor outcomes. We report a case of bilateral lung retransplantation complicated by obstruction of the right pulmonary artery secondary to M. abscessus mycotic aneurysm. Aggressive surgical management, including reconstruction of the right pulmonary artery was undertaken with prolonged antimicrobial therapy. 36 months later, antibiotics have been discontinued and the patient has stable soft tissue chest wall disease with good graft function...
January 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Morsal Osmani, David Sotello, Salvador Alvarez, John A Odell, Matthew Thomas
PURPOSE: To evaluate our institutional experience with Mycobacterium abscessus infections occurring in lung transplant recipients (LTR). METHODS: We retrospectively reviewed our prospectively collected institutional adult lung transplant database from 2001 to 2015 to identify patients with M. abscessus or Mycobacterium chelonae/abscessus infection before or after transplantation. Untreated, colonized patients were excluded from the study. Electronic health records of 9 out of 516 lung recipients (1...
January 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Laura Laencina, Violaine Dubois, Vincent Le Moigne, Albertus Viljoen, Laleh Majlessi, Justin Pritchard, Audrey Bernut, Laura Piel, Anne-Laure Roux, Jean-Louis Gaillard, Bérengère Lombard, Damarys Loew, Eric J Rubin, Roland Brosch, Laurent Kremer, Jean-Louis Herrmann, Fabienne Girard-Misguich
Mycobacterium abscessus, a rapidly growing mycobacterium (RGM) and an opportunistic human pathogen, is responsible for a wide spectrum of clinical manifestations ranging from pulmonary to skin and soft tissue infections. This intracellular organism can resist the bactericidal defense mechanisms of amoebae and macrophages, an ability that has not been observed in other RGM. M. abscessus can up-regulate several virulence factors during transient infection of amoebae, thereby becoming more virulent in subsequent respiratory infections in mice...
January 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
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