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glioma hypertension

Matthias Holdhoff, Xiaobu Ye, Jeffrey G Supko, Louis B Nabors, Arati S Desai, Tobias Walbert, Glenn J Lesser, William L Read, Frank S Lieberman, Martin A Lodge, Jeffrey Leal, Joy D Fisher, Serena Desideri, Stuart A Grossman, Richard L Wahl, David Schiff
Background.: Mibefradil (MIB), previously approved for treatment of hypertension, is a selective T-type calcium channel blocker with preclinical activity in high-grade gliomas (HGGs). To exploit its presumed mechanism of impacting cell cycle activity (G1 arrest), we designed a phase I study to determine safety and the maximum tolerated dose (MTD) of MIB when given sequentially with temozolomide (TMZ) in recurrent (r)HGG. Methods.: Adult patients with rHGG ≥3 months from TMZ for initial therapy received MIB in 4 daily doses (q...
March 22, 2017: Neuro-oncology
Carmen C Beladan, Oliviana D Geavlete, Simona Botezatu, Marin Postu, Bogdan A Popescu, Carmen Ginghina, Ioan M Coman
Renal artery stenosis caused by neurofibromatosis is a rare cause of renovascular hypertension. This hypertension can develop during childhood and is one of the leading causes of poor outcome. We report the case of a 17-year-old girl who was incidentally diagnosed with severe hypertension. During her examination for secondary hypertension, we reached a diagnosis of neurofibromatosis type 1 on the basis of a cluster of typical findings: optic nerve glioma, café au lait spots, nodular neurofibromas, and axillary freckling...
February 2017: Texas Heart Institute Journal
Ashish H Shah, Eric Barbarite, Christopher Scoma, Manish Kuchakulla, Sahil Parikh, Amade Bregy, Ricardo J Komotar
BACKGROUND: Relationships between various ethnicities and glioma subtype have recently been established. As a tertiary referral center for Latin America and the Caribbean, our institution treats a diverse glioblastoma (GBM) population. We sought to clarify the role of ethnicity on patient prognosis in GBM and also compared these findings to a group consisting of elderly patients. We included 'elderly' as a group because the subgroups for ethnicities within them were too small. It allowed us to put in scope the effects of ethnicities on the overall survival...
January 4, 2017: Curēus
Piero Andrea Oppido
Neuroendoscopy is now considered to be a minimally invasive surgical approach for expanding lesions bulging into the ventricle, and it is also considered to be a relevant tool for performing biopsy procedures, fenestration of cystic walls, or for performing tumor removal in selected cases. Furthermore, the use of neuroimaging and the accurate follow-up of brain tumor patients have allowed the documentation of tumoral and pseudotumoral cystic areas that cause the obstruction of cerebrospinal fluid (CSF) pathways...
2017: Acta Neurochirurgica. Supplement
J B Ma, L Chen, B Gao, J Xu
Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were consecutively recruited from the First Hospital of Yulin between March 2013 and May 2015. The IL-18 -607A/C and -372C/G polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism...
October 24, 2016: Genetics and Molecular Research: GMR
K M H Ahanogbe, K Ibahioin, M Karkouri, M B Dianka, W Akpo, A El Azhari
INTRODUCTION: Osteosarcoma is a malignant mesenchymal tumor including cells that present an osteoblastic differentiation. On the skull, it has often extra-axial development associated with bone reaction. We report an atypical and rare case of intracranial or cerebral osteosarcoma underline the radiological and pathological diagnostic difficulties. CASE REPORT: Our case concerns a primary osteosarcoma without bone involvement in a 10-year old boy who was admitted for intracranial hypertension with progressive worsening and brachial monoparesis...
October 2016: Neuro-Chirurgie
Songül Meltem Can, Osman Nuri Türkmenoğlu, Canan Tanik, Ender Uysal, Barış Özöner, Saime Ayça Kaldirimoğlu, Ahmet Murat Müslüman, Adem Yilmaz, Halit Çavuşoğlu, Çiçek Bayindir, Yunus Aydin
AIM: CT-guided stereotactic brain biopsy has been performed in our clinic since March 1998. In this prospective study, we examined the patient data undergoing stereotactic biopsy and the results of biopsies in consecutive 500 patients. MATERIAL AND METHODS: Between the dates of March 1998 and January 2015, CT guided stereotactic biopsies were performed by using the Leksell stereotactic frame system (Elekta Instruments EU, Sweden) in 500 patients. A total of 512 procedures were performed in patients consisting of 184 females (36...
January 25, 2016: Turkish Neurosurgery
Sanaz Benisi-Kohansal, Mehdi Shayanfar, Minoo Mohammad-Shirazi, Hadi Tabibi, Giuve Sharifi, Parvane Saneei, Ahmad Esmaillzadeh
Data on the association of adherence to the Dietary Approaches to Stop Hypertension (DASH)-style and glioma are scarce. We aimed to examine the association between adherence to the DASH-style diet and glioma in Iranian adults. In this study, 128 pathologically confirmed cases of glioma were recruited from hospitals and 256 age- and sex-matched controls were enrolled from other wards of the hospital. Dietary intakes were assessed using a 126-item validated FFQ. Adherence to the DASH-style diet was followed considering the healthy and non-healthy foods emphasised in the DASH dietary pattern...
March 28, 2016: British Journal of Nutrition
Xuekui Zhang, Haitao Ding, Yao Han, Deke Sun, Haitao Wang, X U Zhai
Glioblastoma is a type of glioma with a relatively higher degree of malignancy that may result in severe intracranial hypertension and focal symptoms. Surgery is the preferred treatment modality. Combination therapy including radiotherapy, chemotherapy, gene therapy, immunotherapy and targeted therapy have also been employed. However, due to the invasiveness and pathogenesis of the disease, such treatments do not yield satisfactory outcomes. The aim of the present study was to examine the expression of microRNA (miR)-184 in Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in the mechanism of glioblastoma formation, thus providing a new basis for the mechanism of glioblastoma induction...
December 2015: Oncology Letters
Elisabeth Bumes, Sarah Rzonsa, Markus Hutterer, Martin Proescholdt, Ulrich Bogdahn, Markus J Riemenschneider, Martin Uhl, Christina Wendl, Peter Hau
Anti-VEGF therapy with Bevacizumab (BEV) is widely used in cases of relapsed high-grade glioma (HGG). Arterial hypertension is a known side effect of anti-VEGF therapy. 42 Patients with relapsed HGG were treated with BEV 10 mg/kg on days 1 and 15 of 28-day cycles in addition to treatment with 40 mg TMZ daily until disease progression, based on magnetic resonance imaging and/or worsening of clinical status. In a retrospective analysis, hypertensive side effects were evaluated as the primary endpoint, while survival information in addition to toxicity was analyzed as secondary endpoint...
March 2016: Journal of Neuro-oncology
Yoshitaka Narita
Individuals with glioblastoma are often characterized by older age, advanced neurologic manifestations at the primary stage, and unresectable tumors, and these factors are associated with poor treatment outcomes. Administration of bevacizumab (BV, Avastin(®)) promotes tumor regression and improves cerebral edema, and is expected to improve neurologic findings in many patients with malignant gliomas, including glioblastoma. Although the addition of BV to the conventional standard therapy (chemoradiotherapy with temozolomide) for newly diagnosed glioblastoma prolonged the progression-free survival time and the performance status of patients, it failed to extend overall survival time...
2015: Therapeutics and Clinical Risk Management
Trent R Hummel, Ralph Salloum, Rachid Drissi, Shiva Kumar, Matthew Sobo, Stewart Goldman, Ahna Pai, James Leach, Adam Lane, David Pruitt, Mary Sutton, Lionel M Chow, Laurie Grimme, Renee Doughman, Lori Backus, Lili Miles, Charles Stevenson, Maryam Fouladi, Mariko DeWire
Although bevacizumab has not proven effective in adults with newly diagnosed high-grade gliomas (HGG), feasibility in newly diagnosed children with diffuse intrinsic pontine gliomas (DIPG) or HGG has not been reported in a prospective study. In a safety and feasibility study, children and young adults with newly diagnosed HGG received radiotherapy (RT) with bevacizumab (10 mg/kg: days 22, 36) and temozolomide (75-90 mg/m(2)/day for 42 days) followed by bevacizumab (10 mg/kg, days 1, 15), irinotecan (125 mg/m(2), days 1, 15) and temozolomide (150 mg/m(2)/day days 1-5)...
March 2016: Journal of Neuro-oncology
O Tyurikova, Y Dembitskaya, K Yashin, M Mishchenko, M Vedunova, I Medyanik, V Kazantsev
Amongst large a variety of oncological diseases, malignant gliomas represent one of the most severe types of tumors. They are also the most common type of the brain tumors and account for over half of the astrocytic tumors. According to different sources, the average life expectancy of patients with various glioblastomas varies between 10 and 12 months and that of patients with anaplastic astrocytic tumors between 20 and 24 months. Therefore, studies of the physiology of transformed glial cells are critical for the development of treatment methods...
2015: Computational and Mathematical Methods in Medicine
Yan Yong, Wang Hongxiang, Xu Tao, Qin Rong, Lu Chengyin, Hu Guohan, Yicheng Lu, Chen Juxiang
OBJECTIVE: To explore the diagnosis and treatment of multicentric glioma and discuss its underlying pathological mechanism. METHODS: The clinical cases of multicentric glioma at our department were prospectively collected from January 2012 to December 2014. A total of 62 cases, along with the literally reported cases with relative complete data, were studied with Kaplan-Meier and COX regression to identify the prognostic factors of disease. RESULTS: The median age was 55...
April 7, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
C Robba, S Bacigaluppi, D Cardim, J Donnelly, M S Sekhon, M J Aries, G Mancardi, A Booth, N L Bragazzi, M Czosnyka, B Matta
Non-invasive measurement of ICP (nICP) can be warranted in patients at risk for developing increased ICP during pneumoperitoneum (PP). Our aim was to assess available data on the application of nICP monitoring during these procedures and to present a patient assessed with an innovative combination of noninvasive tools. Literature review of nICP assessment during PP did not find any studies comparing different methods intraprocedurally and only few studies of any nICP monitoring were available: transcranial Doppler (TCD) studies used the pulsatility index (PI) as an estimator of ICP and failed to detect a significant ICP increase during PP, whereas two out of three optic nerve sheath diameter (ONSD) studies detected a statistically significant ICP increase...
October 2016: Journal of Clinical Monitoring and Computing
Tom Dubov, Hagit Toledano-Alhadef, Gil Chernin, Shlomi Constantini, Roxana Cleper, Shay Ben-Shachar
BACKGROUND: Neurofibromatosis type 1 (NF1) is a common neurocutaneous disease characterized by café-au-lait spots, axillary and inguinal freckling, neurofibromas, and optic gliomas. Increased rates of hypertension (HTN) were reported among NF1 patients, however, the prevalence of HTN and pre-HTN in pediatric NF1 patients has not been clarified. METHODS: Blood pressure (BP) measurements, weight, and renal ultrasound were assessed in 224 NF1 pediatric patients followed in a specialized NF1 clinic...
January 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
R Tatapudi, M Tripurasundari, K Asra, N L N Moothi
INTRODUCTION: The posterior reversible encephalopathy syndrome-PRES is recognised as the neuro radiologic abnormality in Eclampsia and with prompt treatment and delivery is usually reversible. OBJECTIVES: To study neuro radiological and biochemical abnormalities in severe preeclampsia and eclampsia and their reversibility following delivery. METHODS: 100 Women with severe pre-eclampsia and eclampsia admitted to High risk unit at Gandhi Hospital, Secunderabad were studied between September 2008 and September 2010...
July 2012: Pregnancy Hypertension
Josué Rakotonjanahary, Emilie De Carli, Matthieu Delion, Chantal Kalifa, Jacques Grill, François Doz, Pierre Leblond, Anne-Isabelle Bertozzi, Xavier Rialland
BACKGROUND: In terms of overall survival (OS), limited data are available for the very long-term outcomes of children treated for optic pathway glioma (OPG) with up-front chemotherapy. Therefore, we undertook this study with the aim of clarifying long-term OS and causes of death in these patients. METHODS: We initiated and analyzed a historical cohort study of 180 children with OPG treated in France with BB-SFOP chemotherapy between 1990 and 2004. The survival distributions were estimated using Kaplan-Meier method...
2015: PloS One
Annelise Letourneur, Simon Roussel, Myriam Bernaudin, Fabien Fillesoye, Jérôme Toutain, Eric T MacKenzie, Edwige Petit, Omar Touzani, Samuel Valable
Glioblastoma is the most aggressive brain tumor and is almost always fatal. These tumors are highly vascularized and angiogenesis is one of the pre-eminent mechanisms underlying their growth. Chronic arterial hypertension (CAH) is a common and worldwide pathology that markedlly alters the structure and function of the vasculature. Yet, essential hypertension is associated in the brain with potential locally impaired vasoreactivity, disturbed perfusion supply and hypoxia phenomena. Even though CAH is a global burden and has an important impact on brain function, nothing is known about the way this frequent pathology would interact with the evolution of glioma...
November 2015: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Carlos Kamiya-Matsuoka, David Cachia, Adriana Olar, Terri S Armstrong, Mark R Gilbert
BACKGROUND: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic encephalopathic state associated with reversible cerebral vasogenic edema. It is an increasingly recognized occurrence in the oncology population. However, it is very uncommon in patients with primary brain tumors (PBTs). The aim of this study was to analyze the clinicoradiological features and report the clinical outcomes of PRES in PBT patients. METHODS: We identified 4 cases with PBT who developed PRES at MD Anderson Cancer Center (MDACC) between 2012 and 2014...
December 2014: Neuro-oncology Practice
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