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https://www.readbyqxmd.com/read/29350137/multiplex-pcr-based-next-generation-sequencing-and-global-diversity-of-seoul-virus-in-humans-and-rats
#1
Won-Keun Kim, Jin Sun No, Seung-Ho Lee, Dong Hyun Song, Daesang Lee, Jeong-Ah Kim, Se Hun Gu, Sunhye Park, Seong Tae Jeong, Heung-Chul Kim, Terry A Klein, Michael R Wiley, Gustavo Palacios, Jin-Won Song
Seoul virus (SEOV) poses a worldwide public health threat. This virus, which is harbored by Rattus norvegicus and R. rattus rats, is the causative agent of hemorrhagic fever with renal syndrome (HFRS) in humans, which has been reported in Asia, Europe, the Americas, and Africa. Defining SEOV genome sequences plays a critical role in development of preventive and therapeutic strategies against the unique worldwide hantavirus. We applied multiplex PCR-based next-generation sequencing to obtain SEOV genome sequences from clinical and reservoir host specimens...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29349620/fatal-talaromyces-marneffei-infection-in-a-patient-with-autoimmune-hepatitis
#2
Sally C Y Wong, Siddharth Sridhar, Antonio H Y Ngan, Jonathan H K Chen, Rosana W S Poon, Susanna K P Lau, Patrick C Y Woo
Talaromyces marneffei, previously known as Penicillium marneffei, is the most important pathogenic thermally dimorphic fungus causing systemic mycosis in Southeast Asia. Traditionally, T. marneffei infection in human was mainly associated with acquired immunodeficiency syndrome caused by HIV infection. In recent years, there has been an increasing number of T. marneffei infections reported in non-HIV-infected patients with other immunocompromised conditions, including autoantibodies against interferon-gamma, systemic lupus erythematosis, solid organ transplantation, Job's syndrome, hematological malignancies, and use of novel targeted therapies...
January 18, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29342266/causes-patterns-and-severity-of-androgen-excess-in-1205-consecutively-recruited-women
#3
Yasir S Elhassan, Jan Idkowiak, Karen Smith, Miriam Asia, Helena Gleeson, Rachel Webster, Wiebke Arlt, Michael W O'Reilly
Context: Androgen excess in women is predominantly due to underlying polycystic ovary syndrome (PCOS). However there is a lack of clarity regarding patterns and severity of androgen excess that should be considered predictive of non-PCOS pathology. Objective: We examined the diagnostic utility of simultaneous measurement of serum dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4) and testosterone (T) to delineate biochemical signatures and cut-offs predictive of non-PCOS disorders in women with androgen excess...
January 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29337417/guillain-barr%C3%A3-syndrome-in-a-local-area-in-japan-2006-2015-an-epidemiological-and-clinical-study-of-108-patients
#4
Naoko Matsui, Hiroyuki Nodera, Daisuke Kuzume, Naoki Iwasa, Yuki Unai, Waka Sakai, Yoshimichi Miyazaki, Hiroki Yamazaki, Yusuke Osaki, Takahiro Furukawa, Masahiro Yamasaki, Yuishin Izumi, Susumu Kusunoki, Kokichi Arisawa, Ryuji Kaji
BACKGROUND: Many epidemiological studies of Guillain-Barré syndrome (GBS) and Fisher syndrome (FS) have been conducted in Europe and America. In contrast, epidemiological studies are rare in Asia where the GBS subtypes differ from those in Western countries. This study was undertaken to clarify the incidence of GBS and FS in a local area in Japan as well as their seasonal trends. METHODS: Seventy-one GBS and 37 FS patients were recorded from 2006 to 2015 in an area of approximately 1...
January 16, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29321316/two-residues-in-nsp9-contribute-to-the-enhanced-replication-and-pathogenicity-of-highly-pathogenic-porcine-reproductive-and-respiratory-syndrome-virus
#5
Kuan Zhao, Jia-Cong Gao, Jun-Yao Xiong, Jin-Chao Guo, Yong-Bo Yang, Cheng-Gang Jiang, Yan-Dong Tang, Zhi-Jun Tian, Xue-Hui Cai, Guang-Zhi Tong, Tong-Qing An
Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) possesses greater replicative capacity and pathogenicity than classical PRRSV. However, the factors that lead to enhanced replication and pathogenicity remain unclear. In our study, an alignment of all available full-length sequences of North-American type PRRSVs (n = 204) revealed two consistent amino acid mutations that differed between HP-PRRSV and classical PRRSV and were located at positions 519 and 544 in non-structural protein 9...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29318332/-zika-virus-infection-and-the-nervous-system
#6
REVIEW
I W Husstedt, M Maschke, C Eggers, E Neuen-Jacob, G Arendt
Zika virus is an arbovirus from the family of flaviviruses, which is transmitted by the mosquito Aedes aegyptii and also by the Asian mosquito Aedes albopticus. The largest observed Zika virus epidemic is currently taking place in North and South America, in the Caribbean, southern USA and Southeast Asia. In most cases the infection is an unspecific, acute, febrile disease. Neurological manifestations consist mainly of microcephaly in newborns and Guillain-Barré syndrome but other rare manifestations have also become known in the meantime, such as meningoencephalitis and myelitis...
January 9, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29289665/disulfiram-can-inhibit-mers-and-sars-coronavirus-papain-like-proteases-via-different-modes
#7
Min-Han Lin, David C Moses, Chih-Hua Hsieh, Shu-Chun Cheng, Yau-Hung Chen, Chiao-Yin Sun, Chi-Yuan Chou
Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in southern China in late 2002 and caused a global outbreak with a fatality rate around 10% in 2003. Ten years later, a second highly pathogenic human CoV, MERS-CoV, emerged in the Middle East and has spread to other countries in Europe, North Africa, North America and Asia. As of November 2017, MERS-CoV had infected at least 2102 people with a fatality rate of about 35% globally, and hence there is an urgent need to identify antiviral drugs that are active against MERS-CoV...
December 28, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29288183/performance-of-syndromic-management-for-the-detection-and-treatment-of-genital-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-among-women-attending-antenatal-well-woman-and-sexual-health-clinics-in-papua-new-guinea-a-cross-sectional-study
#8
Lisa M Vallely, Pamela Toliman, Claire Ryan, Glennis Rai, Johanna Wapling, Josephine Gabuzzi, Joyce Allen, Christine Opa, Gloria Munnull, Petronia Kaima, Benny Kombuk, Antonia Kumbia, Zure Kombati, Greg Law, Angela Kelly-Hanku, Handan Wand, Peter M Siba, Glen D L Mola, John M Kaldor, Andrew J Vallely
OBJECTIVE: Papua New Guinea (PNG) has among the highest estimated prevalences of genital Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) of any country in the Asia-Pacific region. Diagnosis and treatment of these infections have relied on the WHO-endorsed syndromic management strategy that uses clinical presentation without laboratory confirmation to make treatment decisions. We evaluated the performance of this strategy in clinical settings in PNG...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29286017/a-case-of-invasive-infection-caused-by-a-highly-virulent-strain-of-klebsiella-pneumoniae-displaying-hypermucoviscosity-in-a-patient-with-hepatic-involvement-without-liver-abscess
#9
Margherita Scapaticci, Marta Biscaro, Francesco Burelli, Lucio Cadamuro, Renzo Biscaro, Andrea Bartolini
Klebsiella pneumoniae is an opportunistic nosocomial pathogen belonging to the Enterobacteriaceae family that is associated with a wide range of infections. In the 1980s a new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae (hvKP) emerged in southeast Asia and is now increasingly spreading to Western countries due to an invasive syndrome. hvKP isolates can cause serious, life-threatening community-acquired infections in younger healthy hosts, including liver abscess, pneumonia, meningitis and endophthalmitis...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29284248/streptococcus-suis-a-re-emerging-pathogen-associated-with-occupational-exposure-to-pigs-or-pork-products-part-i-epidemiology
#10
Jacek Dutkiewicz, Jacek Sroka, Violetta Zając, Bernard Wasiński, Ewa Cisak, Anna Sawczyn, Anna Kloc, Angelina Wójcik-Fatla
<i>Streptococcus suis</i> (ex Elliot 1966, Kilpper-Bälz & Schleifer 1987) is a facultatively anaerobic Gram-positive ovoid or coccal bacterium surrounded by a polysaccharide capsule. Based on the antigenic diversity of the capsule, <i>S. suis</i> strains are classified serologically into 35 serotypes. <i>Streptococcus suis</i> is a commensal of pigs, commonly colonizing their tonsils and nasal cavities, mostly in weaning piglets between 4-10 weeks of age. This species occurs also in cattle and other mammals, in birds and in humans...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29281106/delayed-ifn-type-1-induced-antiviral-state-is-a-potential-factor-for-hfrs-severity
#11
Katarina Resman Rus, Miša Korva, Petra Bogovic, Emil Pal, Franc Strle, Tatjana Avšic-Županc
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia. Interferon (IFN) responses play an important role in HFRS pathogenesis and it is known that the early IFNβ response is delayed by pathogenic hantaviruses. The clinical severity of HFRS caused by Dobrava virus (DOBV) and Puumala virus (PUUV) varies greatly and the aim of our study was to determine whether differences in early activation of the IFN type 1-induced antiviral state influence HFRS severity. Peripheral blood mononuclear cells (PBMCs) from healthy donors and HFRS patients were stimulated with DOBV or PUUV and the expression of selected genes was measured...
December 21, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29245334/fatty-acid-components-in-asian-female-patients-with-irritable-bowel-syndrome
#12
Chian Sem Chua, Shih-Yi Huang, Chiao-Wen Cheng, Chyi-Huey Bai, Chien-Yeh Hsu, Hung-Wen Chiu, Jung-Lung Hsu
Abdominal pain is one of the key symptoms of irritable bowel syndrome (IBS). Studies have indicated an increase in the incidence of IBS in Asia. However, yet the pathophysiology of this disease remains unknown. Women are more likely to develop the condition than men, especially the constipation-predominant type. Essential fatty acid (EFA) malnutrition is one of several theories discussing the mechanism of IBS.The authors hypothesized that significant EFA deficiency may cause abdominal pain in patients with IBS...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29243580/coumarins-as-promising-scaffold-for-the-treatment-of-age-related-diseases-an-overview-of-the-last-five-years
#13
Giovanna Lucia Delogu, Maria Joao Matos
Degenerative diseases are becoming increasingly prevalent with the aging of the human population. The twentieth century witnessed a significant demographic change in the industrialized world that is currently followed by a similar shift of life expectancy to upper age ranges in Asia, Africa, and Middle and South America. A rising tide of chronic age-dependent diseases will soon present serious challenges for these countries. Age-related diseases are commonly seen in older patients. More than 40% of adults 60 and older have a combination of risk factors known as metabolic syndrome, which increases the risk for developing degenerative disorders, and certain cancers...
December 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29235414/zikaplan-zika-preparedness-latin-american-network
#14
A Wilder-Smith, R Preet, K E Renhorn, R A Ximenes, L C Rodrigues, T Solomon, J Neyts, L Lambrechts, H Willison, R Peeling, A K Falconar, A R Precioso, J Logan, T Lang, H P Endtz, M C Erasmus, E Massad
The ongoing Zika virus (ZIKV) outbreak in Latin America, the Caribbean, and the Pacific Islands has underlined the need for a coordinated research network across the whole region that can respond rapidly to address the current knowledge gaps in Zika and enhance research preparedness beyond Zika. The European Union under its Horizon 2020 Research and Innovation Programme awarded three research consortia to respond to this need. Here we present the ZikaPLAN (Zika Preparedness Latin American Network) consortium...
2017: Global Health Action
https://www.readbyqxmd.com/read/29233897/phylogenetics-of-a-fungal-invasion-origins-and-widespread-dispersal-of-white-nose-syndrome
#15
Kevin P Drees, Jeffrey M Lorch, Sebastien J Puechmaille, Katy L Parise, Gudrun Wibbelt, Joseph R Hoyt, Keping Sun, Ariunbold Jargalsaikhan, Munkhnast Dalannast, Jonathan M Palmer, Daniel L Lindner, A Marm Kilpatrick, Talima Pearson, Paul S Keim, David S Blehert, Jeffrey T Foster
Globalization has facilitated the worldwide movement and introduction of pathogens, but epizoological reconstructions of these invasions are often hindered by limited sampling and insufficient genetic resolution among isolates. Pseudogymnoascus destructans, a fungal pathogen causing the epizootic of white-nose syndrome in North American bats, has exhibited few genetic polymorphisms in previous studies, presenting challenges for both epizoological tracking of the spread of this fungus and for determining its evolutionary history...
December 12, 2017: MBio
https://www.readbyqxmd.com/read/29224924/prevalence-of-spontaneous-brugada-ecg-pattern-recorded-at-standard-intercostal-leads-a-meta-analysis
#16
Shaobo Shi, Hector Barajas-Martinez, Tao Liu, Yaxun Sun, Bo Yang, Congxin Huang, Dan Hu
OBJECTIVE: Typical Brugada ECG pattern is the keystone in the diagnosis of Brugada syndrome. However, the exact prevalence remains unclear, especially in Asia. The present study was designed to systematically evaluate the prevalence of spontaneous Brugada ECG pattern recorded at standard leads. METHODS: We searched the Medline, Embase and Chinese National Knowledge Infrastructure (CNKI) for studies of the prevalence of Brugada ECG pattern, published between Jan 1, 2003, and September 1, 2016...
December 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29210509/arboviruses-and-their-related-infections-in-china-a-comprehensive-field-and-laboratory-investigation-over-the-last-3-decades
#17
REVIEW
Guodong Liang, Xiaolong Li, Xiaoyan Gao, Shihong Fu, Huanyu Wang, Minghua Li, Zhi Lu, Wuyang Zhu, Xinjun Lu, Lihua Wang, Yuxi Cao, Ying He, Wenwen Lei
Since the 1980s, a comprehensive field and laboratory investigation has been conducted throughout China, and a total of 29 virus species belonging to 7 families and 13 genera were identified through virological, morphological, and immunological methods, as well as whole-genome sequencing and molecular genetic analyses. Most of the virus isolates belong to 9 genera in the families Flaviviridae, Bunyaviridae, Togaviridae, and Reoviridae. Among them, 4 genera (Orthobunyavirus, Bunyavirus, Phlebovirus, and Nairovirus) belong to the family Bunyaviridae and 3 genera (Seadonavirus, Orbivirus, and Cypovirus) belong to the family Reoviridae...
December 6, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29209473/correlation-of-cardiovascular-risk-factors-with-central-obesity-and-multiple-body-mass-index-in-korea
#18
Bora Yoo, Hosuk Nam, In Cheol Hwang, Youngmin Park
Background: Body mass index (BMI) and waist circumference (WC) are associated with cardiovascular (CV) risk factors. The aim of this study was to investigate the correlation of CV risk factors by cross-tabulating central obesity with multiple BMI categories in Korea. Methods: A total of 328,789 adults aged 30-84 years who completed health assessments for National Health Insurance in 2012-2013 in Korea were examined. The participants were divided into two WC and five BMI groups to investigate CV risk factors, including metabolic syndrome (MetS), hypertension, diabetes, and dyslipidemia...
November 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29202617/prevalence-of-polycystic-ovary-syndrome-in-thai-university-adolescents
#19
Jetsadaporn Kaewnin, Orawin Vallibhakara, Sakda Arj-Ong Vallibhakara, Penpun Wattanakrai, Benjamaporn Butsripoom, Ekasith Somsook, Sirichai Hongsanguansri, Areepan Sophonsritsuk
Polycystic ovarian syndrome (PCOS) is a common and complex condition characterized by endocrine features and influenced by genetic and environmental factors. In Southeast Asia and Thailand, the prevalence of PCOS is unknown. The aim of this study was to estimate the prevalence of and determine factors associated with PCOS in Thai adolescents. We administered a validated questionnaire to 600 university female participants aged 17-19 years from Mahidol University in Bangkok. Of these, 548 (91.33%) responded and agreed to participate...
December 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29199390/autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-related-to-biomaterials-analysis-of-45-cases-and-comprehensive-review-of-the-literature
#20
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Natalia Gil-Aliberas, Victor Garcia-Gimenez
Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and methacrylate compounds in a Spanish patient cohort. This study is a retrospective analysis of clinical, laboratory, histopathological and follow-up data of 45 cases of patients suffering from late-onset, non-infectious inflammatory/autoimmune disorders related to bioimplants...
December 3, 2017: Immunologic Research
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