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https://www.readbyqxmd.com/read/29224084/bipolar-dual-lead-spinal-cord-stimulation-between-two-electrodes-on-the-ventral-and-dorsal-sides-of-the-spinal-cord-consideration-of-putative-mechanisms
#1
Mitsuru Watanabe, Takamitsu Yamamoto, Chikashi Fukaya, Toshiki Obuchi, Toshikazu Kano, Kazutaka Kobayashi, Hideki Oshima, Atsuo Yoshino
We have applied bipolar dual-lead spinal cord stimulation (SCS) between two cylinder-type electrodes placed on the ventral and dorsal sides of the spinal cord (dual-VD-SCS). A 36-year-old man suffered from burning pain from his right elbow down to his hand after brachial plexus avulsion. The areas with paresthesia induced by conventional SCS did not include the painful hand area. However, dual-VD-SCS completely induced paresthesia in the painful hand area. We speculate that dual-VD-SCS can be applied to stimulate deeper sites of the dorsal column and dorsal horn than conventional SCS and is useful for pain reduction...
December 9, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29211657/open-to-air-is-a-viable-option-for-initial-wound-care-in-necrotizing-soft-tissue-infection-that-allows-early-detection-of-recurrence-without-need-for-painful-dressing-changes-or-return-to-operating-room
#2
Derek Yang, April Davies, Bailey Burge, Phillip Watkins, Sharmila Dissanaike
BACKGROUND: The standard treatment of necrotizing soft tissue infection (NSTI) includes extensive surgical debridement. Care of these debridements is challenging because of the size of the wound and associated pain. A potential solution is to leave the wounds open-to-air in the period after the initial debridement, allowing for regular inspection at bedside while reducing pain associated with frequent dressing changes. We evaluated the feasibility of this approach from a pain control standpoint...
December 6, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29206774/associations-between-improvement-in-genitourinary-symptoms-of-menopause-and-changes-in-the-vaginal-ecosystem
#3
Caroline M Mitchell, Sujatha Srinivasan, Anna Plantinga, Michael C Wu, Susan D Reed, Katherine A Guthrie, Andrea Z LaCroix, Tina Fiedler, Matthew Munch, Congzhou Liu, Noah G Hoffman, Ian A Blair, Katherine Newton, Ellen W Freeman, Hadine Joffe, Lee Cohen, David N Fredricks
OBJECTIVE: The aim of the study was to identify associations between improvement in genitourinary symptoms of menopause (GSM) and vaginal microbiota, vaginal glycogen, and serum estrogen. METHODS: Thirty postmenopausal women enrolled in a hot flash treatment trial (oral estradiol vs venlafaxine vs placebo) who reported GSM and provided vaginal swabs at 0, 4, and 8 weeks were studied. Bacterial communities were characterized using deep sequencing targeting the 16S rRNA gene V3-V4 region...
December 4, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29204893/the-development-of-a-patient-reported-outcome-measure-for-assessment-of-genital-psoriasis-symptoms-the-genital-psoriasis-symptoms-scale-gpss
#4
Alice B Gottlieb, Brian Kirby, Caitriona Ryan, April N Naegeli, Russel Burge, Alison Potts Bleakman, Milena D Anatchkova, Gil Yosipovitch
INTRODUCTION: Patient-reported outcome measures (PROs) specific for genital psoriasis (GenPs) have not been described. METHODS: In this cross-sectional, qualitative study in patients with moderate-to-severe GenPs, we sought to develop a PRO useful for GenPs symptom assessment. A literature review was performed to identify relevant psoriasis or GenPs symptoms and existing PROs that may be useful in the evaluation of symptom severity in GenPs patients. The literature review findings were discussed with clinicians, and then patients with GenPs...
December 4, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29202395/generalized-unprovoked-vulvodynia-a-retrospective-study-on-the-efficacy-of-treatment-with-amitriptyline-gabapentin-or-pregabalin
#5
Heleen J van Beekhuizen, Jessica Oost, Willem I van der Meijden
OBJECTIVE: To describe patient characteristics of women diagnosed with generalized unprovoked vulvodynia (GUV) and to estimate efficacy and tolerability of treatment. MATERIAL AND METHODS: Retrospective observational study in 241 women who presented with GUV at three vulvar disease clinics in Rotterdam, The Netherlands during 1996-2013. Main outcome was efficacy of amitriptyline, gabapentin or pregabalin treatment. RESULTS: The median duration of symptoms was 24 months and median age 62 years (range 36-89)...
October 31, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29199384/low-intensity-led-therapy-658%C3%A2-nm-on-burn-healing-a-series-of-cases
#6
Rauirys Alencar de Oliveira, Luara Lis Barbosa Boson, Seísa Marina Martins Portela, Antônio Luiz Martins Maia Filho, Denyberg de Oliveira Santiago
The objective of this study was to evaluate the effects of LED on burns healing. Five patients with skin burns were submitted to photobiomodulation by LED, GaAsIP diode, (λ 658 nm) with 40 mW, 7 J/cm2 on every other day. Biopsies of burned skin were performed and the healing process was photographed. Patients with bilateral burns were used as self-control, having one limb being irradiated and the contralateral limb irradiated with placebo. The burns treated with LED showed higher epithelization, with keratinocytes and fibroblasts proliferation, increased collagen synthesis, decreased pain, and pruritus...
December 4, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29194773/plasma-il-8-signature-correlates-with-pain-and-depressive-symptomatology-in-patients-with-burning-mouth-syndrome-results-from-a-pilot-study
#7
Alison Barry, Ken D O'Halloran, Joseph P McKenna, Christine McCreary, Eric J Downer
BACKGROUND: Burning mouth syndrome (BMS) is a neuropathic orofacial pain condition of unknown aetiology that encompasses intra-oral burning pain without abnormal clinical findings. Psychological, neural and inflammatory processes are associated with BMS pathogenesis. Currently, studies characterising plasma cytokine/chemokine profiles with pain and depression in BMS patients are lacking. Considering that inflammation is associated with the pathophysiology of BMS, and that inflammation is closely associated with pain and depression, we aimed to correlate depressive symptomatology and oral cavity pain with plasma cytokine/chemokine signatures in a cohort of patients with BMS...
December 1, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29192294/primary-burning-mouth-syndrome-literature-review-and-preliminary-findings-suggesting-possible-association-with-pain-modulation
#8
Cibele Nasri-Heir, Diana Shigdar, Deyaaeddin Alnaas, Olga Anna Korczeniewska, Rotem Eliav, Gary M Heir
Primary burning mouth syndrome (BMS) is a chronic pain of a burning quality affecting the tongue and intraoral mucosa. Currently, there are no definite diagnostic criteria; therefore, the diagnosis is made by exclusion of potential local and systemic causes that could justify the burning sensation. The etiology behind primary BMS remains unclear; however, the most acceptable theories link primary BMS with neuropathic pain. This article provides a review of primary BMS diagnosis, mechanisms, and treatment with focus on the association of BMS with pain modulation...
November 30, 2017: Quintessence International
https://www.readbyqxmd.com/read/29188163/notalgia-paresthetica-a-novel-approach-to-treatment-with-cryolipolysis
#9
REVIEW
Philip R Cohen
Notalgia paresthetica, a neurosensory syndrome that typically occurs on the upper back, has multiple clinical symptoms with variable degrees of expression in each individual afflicted with the condition. The involved site is usually hyperpigmented and is associated with burning, coldness, hypoesthesia, increased pain, pruritus and/or tingling. In the affected area, the number of nerve fibers may be increased and the cutaneous sensory nerves are altered secondary to localized impingement, central injury, or both...
September 28, 2017: Curēus
https://www.readbyqxmd.com/read/29183752/a-1-year-comparison-of-a-community-based-exercise-program-versus-a-day-hospital-based-exercise-program-on-quality-of-life-and-mental-health-in-severely-burned-children
#10
Raquel Peña, Oscar E Suman, Marta Rosenberg, Clark R Andersen, David N Herndon, Walter J Meyer
OBJECTIVE: To compare the effects of long term psychosocial functioning and mental health of a "Day-Hospital" Based Exercise Program (DAYEX) versus a Community Based Exercise Program (COMBEX). DESIGN: This was a prospective design that consisted of two groups (DAYEX and COMBEX). SETTING: A children's hospital specialized in burn care (Shriner's Hospitals for Children, Inc., Galveston, Texas) PARTICIPANTS: A total of 18 patients, (n=9 DAYEX and n=9 COMBEX) were assessed at Intensive Care Unit (ICU) discharge and up to 1 year post burn...
November 25, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29180561/notalgia-paresthetica-relieved-by-cervical-traction
#11
Rhonda Low, Leah A Swanson, David L Swanson
Notalgia paresthetica is a syndrome of unilateral, chronic pruritis that is associated with burning pain, paresthesia, numbness, and hyperesthesia localized to the medial and inferior scapula. The condition does not respond to anti-inflammatory drugs or traditional antipruritic agents and has variable responses to numerous other reported pharmacologic and nonpharmacologic therapies. Although the etiology is thought to be nerve impingement, neurologic and musculoskeletal causes are often not considered in the differential diagnosis...
November 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29179650/statin-related-adverse-effects-and-patient-education-a-study-from-resource-limited-settings
#12
Rubina Mulchandani, Tanica Lyngdoh, Praloy Chakraborty, Ashish Kumar Kakkar
BACKGROUND: Statins are the most widely prescribed class of drugs for coronary artery disease (CAD) patients and yet literature on the prevalence of statin related adverse effects (AEs) and gaps in patient education is quite limited especially in resource-limited settings of developing world. OBJECTIVES: The present study was conducted to determine the prevalence of myopathy (muscle ailments) and other statin associated adverse effects among CAD patients on statin therapy...
November 27, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29178037/a-review-of-neuropathic-pain-from-diagnostic-tests-to-mechanisms
#13
REVIEW
Andrea Truini
Neuropathic pain develops when the somatosensory nervous system is affected by a lesion or disease. Diagnostic tests aimed at assessing somatosensory afferent pathway damage are therefore useful for diagnosing neuropathic pain. Neuropathic pain manifests with a range of different symptoms such as ongoing burning pain, squeezing or pressure pain, paroxysmal electric shock-like sensations, stabbing pain, or mechanical dynamic allodynia. The various types of neuropathic pain are associated with different underlying nerve fiber abnormalities...
December 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29175562/utilisation-and-polypharmacy-aspects-of-antiepileptic-drugs-in-elderly-versus-younger-patients-with-epilepsy-a-pharmacoepidemiological-study-of-cns-active-drugs-in-norway-2004-2015
#14
Arton Baftiu, Silje Andrea Feet, Pål Gunnar Larsson, Margrete Larsen Burns, Oliver Henning, Erik Sætre, Espen Molden, Anne Gerd Granas, Svein I Johannessen, Cecilie Johannessen Landmark
BACKGROUND AND PURPOSE: Many patients with epilepsy use antiepileptic drugs (AEDs) in combination. The elderly is a vulnerable group regarding polypharmacy. The purpose of this study was to investigate changes in utilisation of AEDs, and the extent of polypharmacy with other CNS-active drugs in elderly versus younger patients in Norway. METHODS: This pharmacoepidemiological study included all prescriptions of antiepileptic, antidepressant and antipsychotic drugs from Norwegian pharmacies in the Norwegian Prescription Database (NorPD) (2004-2015)...
November 11, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29174849/-the-advantages-in-using-cyanoacrylate-glue-over-skin-staples-as-a-method-of-skin-graft-fixation-in-the-pediatric-burns-population
#15
P Curings, P-L Vincent, R Viard, P Gir, J-P Comparin, D Voulliaume
INTRODUCTION: Local postoperative care and burn wound management can present with a certain degree of difficulty in the pediatric population. While the use of skin staples as a method of skin graft fixation is a well-known, rapid and simple method, their removal can be painful and may necessitate some sedation or even general anesthesia. We studied in this article the advantages and economic value of using the cyanoacrylate glue as a fixation method for skin grafts. MATERIALS AND METHODS: A comparative study was carried out from 2012 to 2016...
November 23, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29173870/a-reappraisal-of-small-and-large-fiber-damage-in-carpal-tunnel-syndrome-new-insights-into-the-value-of-the-emla-test-for-improving-diagnostic-sensitivity
#16
Leila Triki, Hela G Zouari, Rim Kammoun, Firas Kammoun, Ines Kammoun, Kaouthar Masmoudi, Jean-Pascal Lefaucheur
OBJECTIVES: To reappraise the respective involvement of small- and large-fiber damage in carpal tunnel syndrome (CTS) and to determine the diagnostic sensitivity of autonomic tests compared to conventional nerve conduction study (NCS). METHODS: Thirty-two manual workers complaining of at least unilateral CTS were enrolled. They underwent clinical interview and completed the symptom severity scale of the Boston CTS Questionnaire (sssBCTQ) and the Neuropathic Pain Symptom Inventory (NPSI)...
November 23, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29172876/limbal-stem-cell-transplantation-and-complications
#17
Jia Yin, Ula Jurkunas
Corneal epithelial stem cells are adult somatic stem cells located at the limbus and represent the ultimate source of transparent corneal epithelium. When these limbal stem cells become dysfunctional or deficient, limbal stem cell deficiency (LSCD) develops. LSCD is a major cause of corneal scarring and is particularly prevalent in chemical and thermal burns of the ocular surface. LSCD leads to conjunctivalization of the corneal surface, neovascularization, recurrent or persistent epithelial defects, ocular surface inflammation, and scarring that, in turn, lead to decreased vision, pain, and impaired quality of life...
November 27, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29171374/-from-facial-pain-to-toxic-epidermal-necrolysis-a-rare-complication-of-carbamazepine-usage
#18
M Ahmadi, L van Hoeven, K Bokhoven
BACKGROUND: Toxic epidermal necrolysis (TEN) is a rare disease that is characterised by epidermal loss, often as a result of medication use - particularly sulfonamides and anti-epileptics. People of South-East Asian descent are at increased risk of developing TEN since they may carry the HLA-B*1502 allele. CASE DESCRIPTION: A 61-year-old female of Indonesian descent developed TEN due to carbamazepine use, resulting in admission to the intensive care department of a specialised burn centre in the Netherlands...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29169701/aromatherapy-for-the-relief-of-symptoms-in-burn-patients-a-systematic-review-of-randomized-controlled-trials
#19
REVIEW
Jiae Choi, Ju Ah Lee, Zainab Alimoradi, Myeong Soo Lee
BACKGROUND: Aromatherapy is often used to manage several conditions, including pain, psychological distress, and burn-related symptoms. The objective of this review was to assess the current evidence regarding the efficacy of aromatherapy as a treatment for burn wounds. METHODS: The following fifteen databases and trial registries were searched for studies published between their dates of inception and January 2017: AMED, CINAHL, EMBASE, MEDLINE, and the Cochrane Central Register of Controlled Trials (CENTRAL), as well as six Korean medical databases and four Iranian databases...
November 20, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29169696/efficacy-and-feasibility-of-opioids-for-burn-analgesia-an-evidence-based-qualitative-review-of-randomized-controlled-trials
#20
REVIEW
Chao Yang, Xiao-Min Xu, Guang-Zhao He
Opioids are commonly used for burn analgesia, but no comprehensive reviews have been published on such use. We aimed to assess the literature regarding the effectiveness and side effects of opioids both in adult and pediatric burn patients. We conducted a systematic search of the PubMed, Embase, Cochrane, and Web of Science databases. Information on study characteristics, results, and interventions was extracted. The review identified nine studies that satisfied the inclusion criteria. Burn sizes of patients ranged from 1% to 62% of the body...
November 20, 2017: Burns: Journal of the International Society for Burn Injuries
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