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Pulmonary bacterial co-infection in bronchiolitis

Sandrine Essouri, Philippe Durand, Laurent Chevret, Laurent Balu, Denis Devictor, Brigitte Fauroux, Pierre Tissières
PURPOSE: To determine the optimal level of nasal continuous positive airway pressure (nCPAP) in infants with severe hypercapnic viral bronchiolitis as assessed by the maximal unloading of the respiratory muscles and improvement of breathing pattern and gas exchange. METHODS: A prospective physiological study in a tertiary paediatric intensive care unit (PICU). Breathing pattern, gas exchange, intrinsic end expiratory pressure (PEEPi) and respiratory muscle effort were measured in ten infants with severe hypercapnic viral bronchiolitis during spontaneous breathing (SB) and three increasing levels of nCPAP...
December 2011: Intensive Care Medicine
G Poulakou, J Souto, J Balcells, M Pérez, C Laborda, O Roca, T Tórtola, M Pujol, M Palomar, J Rello
To assess potential differences in epidemiology and management of patients admitted with influenza infection in the intensive care unit (ICU) during the first post-pandemic influenza period. Observational prospective study comparing September 2009-January 2010 with September 2010-January 2011. Variables captured: demographics, co-morbidities, physiological parameters, outcomes and management. Analysis was performed using SPSS v. 13.0; significance was set at p 0.5. Data from 53 patients, 38 adults (age, median 41...
April 2012: Clinical Microbiology and Infection
Mohammad Sawal, Marta Cohen, Jose E Irazuzta, Ramani Kumar, Christine Kirton, Marie-Anne Brundler, Clair Anne Evans, John Andrew Wilson, Parakkal Raffeeq, Amer Azaz, Alexandre T Rotta, Ajay Vora, Amit Vohra, Patricia Abboud, L David Mirkin, Mehrengise Cooper, Megan K Dishop, Jeanine M Graf, Andy Petros, Hilary Klonin
Pertussis carries a high risk of mortality in very young infants. The mechanism of refractory cardio-respiratory failure is complex and not clearly delineated. We aimed to examine the clinico-pathological features and suggest how they may be related to outcome, by multi-center review of clinical records and post-mortem findings of 10 patients with fulminant pertussis (FP). All cases were less than 8 weeks of age, and required ventilation for worsening respiratory symptoms and inotropic support for severe hemodynamic compromise...
October 2009: Pediatric Pulmonology
K Thorburn, S Harigopal, V Reddy, N Taylor, H K F van Saene
BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of viral lower respiratory tract infections (LRTI). Viral LRTI is a risk factor for bacterial superinfection, having an escalating incidence with increasing severity of respiratory illness. A study was undertaken to determine the incidence of pulmonary bacterial co-infection in infants and children with severe RSV bronchiolitis, using paediatric intensive care unit (PICU) admission as a surrogate marker of severity, and to study the impact of the co-infection on morbidity and mortality...
July 2006: Thorax
L Duttweiler, D Nadal, B Frey
In 127 infants admitted to intensive care for RSV bronchiolitis, concomitant bacterial sepsis was a rare event. However, in the subgroup of intubated patients the incidence of bacterial pneumonia was 43.9% (95% CI 31.0-56.8%), half community acquired and half nosocomial. As clinical signs are not helpful in identifying these patients, tracheal aspirates have to be investigated microbiologically on a routine basis in order to start antibiotics in time.
December 2004: Archives of Disease in Childhood
J Eriksson, T Nordshus, K H Carlsen, I Orstadvik, J Westvik, J Eng
Respiratory syncytial virus (RSV) is a frequent cause of bronchiolitis leading to acute admission to hospital in the winter months. A wide range of findings accompanies this disease and the appearances are seldom completely diagnostic. Associated bacterial co-infections are common and we have shown an association with atelectasis among patients with pathogenic bacteria in the nasopharynx.
1986: Pediatric Radiology
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