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https://www.readbyqxmd.com/read/27913870/managing-knee-osteoarthritis-with-yoga-or-aerobic-strengthening-exercise-programs-in-older-adults-a-pilot-randomized-controlled-trial
#1
Corjena Cheung, Jean F Wyman, Ulf Bronas, Teresa McCarthy, Kyle Rudser, Michelle A Mathiason
Although exercise is often recommended for managing osteoarthritis (OA), limited evidence-based exercise options are available for older adults with OA. This study compared the effects of Hatha yoga (HY) and aerobic/strengthening exercises (ASE) on knee OA. Randomized controlled trial with three arms design was used: HY, ASE, and education control. Both HY and ASE groups involved 8 weekly 45-min group classes with 2-4 days/week home practice sessions. Control group received OA education brochures and weekly phone calls from study staff...
December 2, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27908822/how-admission-to-a-vascular-surgery-department-improves-medical-treatment-in-patients-with-lower-extremity-peripheral-arterial-disease
#2
M Thiney, N Della Schiava, P Feugier, P Lermusiaux, J Ninet, A Millon, A Long
OBJECTIVES: All patients with lower extremity peripheral arterial disease (LE-PAD) should benefit from recommended pharmacologic therapies including antiplatelet agents, angiotensin converting enzyme (ACE) inhibitors or Angiotensin receptor blockers (ARBs), and HMG-CoA-reductase inhibitors (statins). In the present study, this triple therapy was defined as the best medical treatment. This study was designed to determine the number of patients who received best medical treatment at admission and at discharge from a vascular surgery department...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27903148/obesity-and-energy-balance-in-gi-cancer
#3
Justin C Brown, Jeffrey A Meyerhardt
The prevalence of overweight (body mass index [BMI], 25 to 29.9 kg/m(2)) and obesity (BMI ≥ 30 kg/m(2)) have increased dramatically in the United States. Because increasing BMI is associated with the development of multiple different cancer types, including most GI cancers, providers will frequently encounter patients with GI cancer who are overweight or obese. Mounting evidence associates overweight and/or obesity with worsened prognosis in multiple GI cancers, including esophageal, gastric, hepatocellular, pancreatic, and colorectal...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27893905/critical-care-interprofessional-education-exploring-conflict-and-power-lessons-learned
#4
Mary Louanne Friend, Richard D Friend, Cassandra Ford, Patrick J Ewell
BACKGROUND: The purpose of this mixed-methods study was to evaluate the effects of an innovative critical care interprofessional education intervention on prelicensure nursing and medical students at a large public university. The class provided opportunities for students to (a) explore stereotypes about each respective profession, (b) examine the occurrence and effects of interprofessional conflict in high-acuity areas, and (c) explore conflict resolution techniques while learning how to perform critical care procedures as a team...
December 1, 2016: Journal of Nursing Education
https://www.readbyqxmd.com/read/27891227/society-for-immunotherapy-of-cancer-consensus-statement-on-immunotherapy-for-the-treatment-of-renal-cell-carcinoma
#5
Brian I Rini, David F McDermott, Hans Hammers, William Bro, Ronald M Bukowski, Bernard Faba, Jo Faba, Robert A Figlin, Thomas Hutson, Eric Jonasch, Richard W Joseph, Bradley C Leibovich, Thomas Olencki, Allan J Pantuck, David I Quinn, Virginia Seery, Martin H Voss, Christopher G Wood, Laura S Wood, Michael B Atkins
Immunotherapy has produced durable clinical benefit in patients with metastatic renal cell cancer (RCC). In the past, patients treated with interferon-alpha (IFN) and interleukin-2 (IL-2) have achieved complete responses, many of which have lasted for multiple decades. More recently, a large number of new agents have been approved for RCC, several of which attack tumor angiogenesis by inhibiting vascular endothelial growth factors (VEGF) and VEGF receptors (VEGFR), as well as tumor metabolism, inhibiting the mammalian target of rapamycin (mTOR)...
2016: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/27871720/-guidelines-for-the-prescription-of-mood-stabilizers-for-adolescents-a-literature-review
#6
G Munch, N Godart
INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different efficacy and tolerance profiles compared to those at other stages of the lifespan. Mood stabilizers are a complex pharmacological category including lithium, some anticonvulsants, and some second generation antipsychotics. Focusing on this class of pharmacological agents, we aim to answer the following questions: in which indications and according to which modalities should mood stabilizers be prescribed during adolescence? METHODS: Information was sought from the websites of the French Haute Autorité de santé (HAS) and Agence nationale de sécurité du médicament et des produits de santé (ANSM), the American Food and Drug Administration (FDA) and the British National Institute for Health and Clinical Excellence (NICE)...
November 18, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27863592/nursing-interventions-in-stroke-care-delivery-an-evidence-based-clinical-review
#7
Dimitrios Theofanidis, Bernard Gibbon
INTRODUCTION: Generally, nursing interventions during the acute stages following a stroke aim at preventing secondary brain injury (intracranial hypertension), maintaining the airways (due to paralysis of the pharynx muscles), providing general body support (vital signs, fluid and electrolyte balance), and anticipating the occurrence of complications (atelectasis and pneumonia). AIM: This literature review is to prioritize nursing interventions for acute stroke and to update nursing roles and input considering recommended levels of evidence of care to date...
December 2016: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/27829042/sympathy-for-the-devil-detailing-the-effects-of-planning-unit-size-thematic-resolution-of-reef-classes-and-socioeconomic-costs-on-spatial-priorities-for-marine-conservation
#8
Jessica Cheok, Robert L Pressey, Rebecca Weeks, Serge Andréfouët, James Moloney
Spatial data characteristics have the potential to influence various aspects of prioritising biodiversity areas for systematic conservation planning. There has been some exploration of the combined effects of size of planning units and level of classification of physical environments on the pattern and extent of priority areas. However, these data characteristics have yet to be explicitly investigated in terms of their interaction with different socioeconomic cost data during the spatial prioritisation process...
2016: PloS One
https://www.readbyqxmd.com/read/27818859/problem-case-based-learning-with-competition-introduced-in-severe-infection-education-an-exploratory-study
#9
Jian-Hua Lei, Yi-Jing Guo, Zi Chen, Yao-Yan Qiu, Guo-Zhong Gong, Yan He
BACKGROUND: Problem/case-based learning (PCBL) is one of the most commonly used educational methods in medical schools. AIM: To further improve PCBL in clinical course of severe infection by introducing competition mode. METHODS: Two classes of medical students were divided into two groups by class-based simple randomization and were taught the course of severe infection by PCBL. A team-based competition was introduced in the study group (n = 35) while not in the control group (n = 36)...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27814769/somatic-cancer-variant-curation-and-harmonization-through-consensus-minimum-variant-level-data
#10
Deborah I Ritter, Sameek Roychowdhury, Angshumoy Roy, Shruti Rao, Melissa J Landrum, Dmitriy Sonkin, Mamatha Shekar, Caleb F Davis, Reece K Hart, Christine Micheel, Meredith Weaver, Eliezer M Van Allen, Donald W Parsons, Howard L McLeod, Michael S Watson, Sharon E Plon, Shashikant Kulkarni, Subha Madhavan
BACKGROUND: To truly achieve personalized medicine in oncology, it is critical to catalog and curate cancer sequence variants for their clinical relevance. The Somatic Working Group (WG) of the Clinical Genome Resource (ClinGen), in cooperation with ClinVar and multiple cancer variant curation stakeholders, has developed a consensus set of minimal variant level data (MVLD). MVLD is a framework of standardized data elements to curate cancer variants for clinical utility. With implementation of MVLD standards, and in a working partnership with ClinVar, we aim to streamline the somatic variant curation efforts in the community and reduce redundancy and time burden for the interpretation of cancer variants in clinical practice...
November 4, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27806435/cardiovascular-toxicities-of-small-molecule-tkis-an-opportunity-for-systems-based-approaches
#11
Sherry-Ann Brown, Lara Nhola, Joerg Herrmann
Once universally considered a rapidly fatal condition, cancer has increasingly become a chronic medical condition and co-morbidities and adverse effects of cancer therapies have become increasingly significant. One of the leading advancements, which has gained traction for the treatment of a variety of malignancies, is the class of small molecule tyrosine kinase inhibitors (TKIs). While in many aspects revolutionary, TKIs have their own profile of side effects, including cardiovascular side effects, the most common being hypertension, congestive heart failure, QTc prolongation, and instances of premature coronary heart disease...
November 2, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27797662/intervention-protocol-for-investigating-yoga-implemented-during-chemotherapy
#12
Stephanie J Sohl, Gurjeet S Birdee, Sheila H Ridner, Amy Wheeler, Sandra Gilbert, Danielle Tarantola, Jordan Berlin, Russell L Rothman
OBJECTIVE: Fatigue and other treatment-related symptoms are critical therapeutic targets for improving quality of life in patients with colorectal cancer during chemotherapy. Yoga is a promising intervention for improving these therapeutic targets and has been primarily investigated in the group-class format, which is less feasible for cancer patients with high symptom burden to attend. Thus, we developed a protocol for implementing yoga individually in the clinic among patients receiving chemotherapy...
January 2016: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/27780939/chinese-expert-consensus-on-multidisciplinary-diagnosis-and-treatment-of-hepatocellular-carcinoma-with-portal-vein-tumor-thrombus-2016-edition
#13
REVIEW
Cheng Shuqun, Chen Minshan, Cai Jianqiang, The National Research Cooperative Group For Diagnosis And Treatment Of Hepatocellular Carcinoma With Tumor Thrombus
Hepatocellular carcinoma is the fourth leading cause of cancer-related morbidity and mortality in China. Portal vein tumor thrombus (PVTT) is common and it worsens prognosis of hepatocellular carcinoma (HCC). There is no internationally accepted consensus or guideline for diagnosis and treatment of HCC with PVTT. Based on existing evidences and common current practices, Chinese Experts on Multidisciplinary Diagnosis and Treatment of HCC with portal vein tumor thrombus met to develop a national consensus on diagnosis and treatment of HCC with PVTT...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27776799/relation-between-clinical-best-practices-and-6-month-outcomes-after-transcatheter-aortic-valve-implantation-with-corevalve-from-the-advance-ii-study
#14
Jan-Malte Sinning, Anna Sonia Petronio, Nicolas Van Mieghem, Giulio Zucchelli, Georg Nickenig, Raffi Bekeredjian, Johan Bosmans, Francesco Bedogni, Marian Branny, Karl Stangl, Jan Kovac, Anna Nordell, Molly Schiltgen, Nicolo Piazza, Peter de Jaegere
Best practices for transcatheter aortic valve implantation with CoreValve include patient screening and valve size selection using multislice computed tomography, adherence to manufacturer recommendations for oversizing, control of implant depth to 6 mm or less, and management of conduction disturbances according to international guidelines. The ADVANCE II study implemented these strategies and demonstrated their relation to clinical outcomes. From October 2011 to April 2013, 200 patients with severe aortic stenosis were enrolled, and 194 were implanted...
September 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27761167/genetics-of-brugada-syndrome
#15
Jyh-Ming Jimmy Juang, Minoru Horie
In 1992, the Brugada syndrome (BrS) was recognized as a disease responsible for sudden cardiac death, characterized by a right bundle-branch block with ST segment elevation in the leads V1 and V2. This syndrome is highly associated with sudden cardiac death, especially in young males. BrS is currently diagnosed in patients with ST-segment elevation showing type 1 morphology ≥ 2 mm in ≥1 leads among the right precordial leads V1 or V2 positioned in the 2nd, 3rd, or 4th intercostal space, and occurring either spontaneously or after a provocative drug test by the intravenous administration of Class I antiarrhythmic drugs...
October 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27753981/pl-02-3-management-of-elderly-hypertension-whom-to-treat-and-how-low-to-go
#16
Michael Weber
: Age is the most powerful cardiovascular risk factor. Based on a meta-analysis of a million control patients in hypertension trials, the Clinical Trialists Collaboration has estimated that doubling of major cardiac and stroke events occurs with age increments of < 10 years (1). Data from the ACCOMPLISH trial, which will be presented at this ISH meeting for the first time, show that patients aged > 70 (mean: 75.2), compared with those < 70 (mean: 63.7), had a 2.82-fold greater event rate for cardiovascular death and a 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27751700/best-clinical-practice-emergency-medicine-management-of-stable-monomorphic-ventricular-tachycardia
#17
Brit Long, Alex Koyfman
BACKGROUND: Ventricular tachycardia (VT) and ventricular fibrillation are the causes of approximately 300,000 deaths per year in the United States. VT is classified based on hemodynamic status and appearance. Stable, monomorphic VT treatment is controversial. OBJECTIVE: Our aim was to provide emergency physicians with an evidence-based review of the medical management of stable, monomorphic VT. DISCUSSION: Stable, monomorphic VT is part of a larger class of ventricular dysrhythmias defined by a rate of at least 120 beats/min with QRS > 120 ms without regularly occurring P:QRS association...
October 14, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27732663/evaluation-of-the-applicability-of-different-age-determination-methods-for-estimating-age-of-the-endangered-african-wild-dog-lycaon-pictus
#18
Moreangels M Mbizah, Gerhard Steenkamp, Rosemary J Groom
African wild dogs (Lycaon pictus) are endangered and their population continues to decline throughout their range. Given their conservation status, more research focused on their population dynamics, population growth and age specific mortality is needed and this requires reliable estimates of age and age of mortality. Various age determination methods from teeth and skull measurements have been applied in numerous studies and it is fundamental to test the validity of these methods and their applicability to different species...
2016: PloS One
https://www.readbyqxmd.com/read/27704550/recommended-strategies-for-the-oral-administration-of-paediatric-medicines-with-food-and-drinks-in-the-context-of-their-biopharmaceutical-properties-a-review
#19
Joana Martir, Talia Flanagan, James Mann, Nikoletta Fotaki
OBJECTIVES: This review focuses on the recommended strategies for the oral administration of paediatric medicines with food in the context of their biopharmaceutical properties. KEY FINDINGS: Acceptability of oral medicines in young patients is more challenging than in adult patients. Mixing oral dosage forms with foods and drinks is sometimes suggested to administer a specific dose and enhance compliance in the paediatric population. In this review, the strategies for the co-administration of paediatric medicines with food and drinks are discussed...
October 5, 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27698305/prevalence-of-breastfeeding-in-italy-a-population-based-follow-up-study
#20
Laura Lauria, Angela Spinelli, Michele Grandolfo
INTRODUCTION: Breastfeeding is widely recommended. Updated data are needed to assess its prevalence and the effectiveness of interventions. Breastfeeding practices in Italy need to be promoted and monitored with updated and standard data The objective of this study is to provide estimates of the prevalence of breastfeeding and exclusively breastfeeding and to identify factors that may be modified to improve them. MATERIALS AND METHODS: Two population-based follow-up surveys were conducted to evaluate the quality of maternal care in 25 Local Health Units (LHUs) in Italy during 2008-2011...
July 2016: Annali Dell'Istituto Superiore di Sanità
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