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https://www.readbyqxmd.com/read/28821867/identification-of-the-n-terminal-transmembrane-domain-of-stard7-and-its-importance-for-mitochondrial-outer-membrane-localization-and-phosphatidylcholine-transfer
#1
Yasuhiro Horibata, Hiromi Ando, Motoyasu Satou, Hiroaki Shimizu, Satomi Mitsuhashi, Yasuo Shimizu, Masahiko Itoh, Hiroyuki Sugimoto
StarD7 facilitates phosphatidylcholine (PC) transfer to mitochondria, and is essential for mitochondrial homeostasis. However, the molecular mechanism for PC transfer by protein remains poorly understood. Herein, we describe a putative novel transmembrane (TM) domain C-terminal to the mitochondria-targeting signal (MTS) sequence at the N-terminus of StarD7. The mature form of StarD7 is integrated and/or associated onto the outer leaflet of the outer mitochondrial membrane (OMM) in HEPA-1 and HepG2 cells. A truncated form of StarD7 lacking the TM domain is distributed in the inner space of the mitochondria, and cannot reverse mitochondrial abnormalities, such as complex formation and PC content, when re-expressed in StarD7-KO HEPA-1 cells...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808407/in-vitro-cell-viability-by-cellprofiler-%C3%A2-software-as-equivalent-to-mtt-assay
#2
Luciana S Gasparini, Nayana D Macedo, Elisângela F Pimentel, Marcio Fronza, Valdemar L Junior, Warley S Borges, Eduardo R Cole, Tadeu U Andrade, Denise C Endringer, Dominik Lenz
OBJECTIVE: This study evaluated in vitro cell viability by the colorimetric MTT stands for 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) (3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay compared to image analysis by CellProfiler(®) software. MATERIALS AND METHODS: Hepatoma (Hepa-1c1c7) and fibroblast (L929) cells were exposed to isolated substances, camptothecin, lycorine, tazettine, albomaculine, 3-epimacronine, trispheridine, galanthine and Padina gymnospora, Sargassum sp...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28807063/performance-of-a-novel-non-fit-tested-hepa-filtering-face-mask
#3
Constance Yung Ting Hui, Czarina Chi Hung Leung, Charles David Gomersall
No abstract text is available yet for this article.
August 15, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28761718/an-observational-study-of-spectators-step-counts-and-reasons-for-attending-a-professional-golf-tournament-in-scotland
#4
Andrew D Murray, Kieran Turner, Daryll Archibald, Chloe Schiphorst, Steffan Arthur Griffin, Hilary Scott, Roger Hawkes, Paul Kelly, Liz Grant, Nanette Mutrie
BACKGROUND: Spectators at several hundred golf tournaments on six continents worldwide may gain health-enhancing physical activity (HEPA) during their time at the event. This study aims to investigate spectators' reasons for attending and assess spectator physical activity (PA) (measured by step count). METHODS: Spectators at the Paul Lawrie Matchplay event in Scotland (August 2016) were invited to take part in this study. They were asked to complete a brief questionnaire with items to assess (1) demographics, (2) reasons for attendance and (3) baseline PA...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28736936/invasive-fungal-infection-following-chemotherapy-for-acute-myeloid-leukaemia-experience-from-a-developing-country
#5
Anu Korula, Aby Abraham, Fouzia N Abubacker, Auro Viswabandya, Kavitha M Lakshmi, O C Abraham, Priscilla Rupali, George M Varghese, Joy S Michael, Alok Srivastava, Vikram Mathews, Biju George
The incidence of invasive fungal infections (IFI) is believed to be higher in patients with acute myeloid leukaemia (AML) undergoing chemotherapy in non-HEPA-filtered rooms. The aim of this study is to review the incidence of IFI in a large cohort of patients with AML treated at a single centre in India. Two hundred and twenty-two patients with AML treated with either induction chemotherapy or salvage chemotherapy between 2008 and 2013 were studied retrospectively. IFI was defined as per the revised EORTC-MSG criteria...
July 23, 2017: Mycoses
https://www.readbyqxmd.com/read/28693587/human-presence-impacts-fungal-diversity-of-inflated-lunar-mars-analog-habitat
#6
A Blachowicz, T Mayer, M Bashir, T R Pieber, P De León, K Venkateswaran
BACKGROUND: An inflatable lunar/Mars analog habitat (ILMAH), simulated closed system isolated by HEPA filtration, mimics International Space Station (ISS) conditions and future human habitation on other planets except for the exchange of air between outdoor and indoor environments. The ILMAH was primarily commissioned to measure physiological, psychological, and immunological characteristics of human inhabiting in isolation, but it was also available for other studies such as examining its microbiological aspects...
July 11, 2017: Microbiome
https://www.readbyqxmd.com/read/28662659/the-start2bike-program-is-effective-in-increasing-health-enhancing-physical-activity-a-controlled-study
#7
Linda Ooms, Cindy Veenhof, Dinny H de Bakker
BACKGROUND: The sports club is seen as a new relevant setting to promote health-enhancing physical activity (HEPA) among inactive population groups. Little is known about the effectiveness of strategies and activities implemented in the sports club setting on increasing HEPA levels. This study investigated the effects of Start2Bike, a six-week training program for inactive adults and adult novice cyclers, on HEPA levels of participants in the Netherlands. METHODS: To measure physical activity, the Short QUestionnaire to ASsess Health-enhancing physical activity was used (SQUASH)...
June 29, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28660591/society-of-behavioral-medicine-sbm-position-statement-sbm-supports-curbing-summertime-weight-gain-among-america-s-youth
#8
Amy Bohnert, Nicole Zarrett, Michael W Beets, Georgia Hall, Joanna Buscemi, Amy Heard, Russell Pate
The Society of Behavioral Medicine recommends adoption of policies at the district, state, and federal levels that minimize weight gain among youth over the summertime, particularly among low-income, minority school-age youth who appear to be at greater risk. Policies that facilitate (1) partnerships between school districts and community organizations to provide affordable summertime programming, (2) strategic efforts by schools and communities to encourage families to enroll and attend summertime programming via the creation of community-wide summertime offerings offices, (3) adoption of joint-use/shared use agreements in communities to promote use of indoor and outdoor school facilities to provide affordable programming during the summer months, and (4) implementation of strategies that help summer programs achieve the Healthy Eating and Physical Activity (HEPA) standards which have been endorsed by the Healthy Out-of-School Time (HOST) coalition...
June 28, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28651580/sex-specific-lung-functional-changes-in-adult-mice-exposed-only-to-second-hand-smoke-in-utero
#9
Alexandra Noël, Rui Xiao, Zakia Perveen, Hasan Zaman, Viviana Le Donne, Arthur Penn
BACKGROUND: An increasing number of epidemiological and experimental studies have associated exposure to second-hand smoke (SHS) during pregnancy with adverse outcomes in newborns. As we have previously shown in mice, in utero exposure to SHS at critical stages of fetal development, results in altered lung responses and increased disease susceptibility upon re-exposure to irritants (SHS or ovalbumin) in adulthood. In this study, we asked whether the in utero SHS exposure alone is sufficient to alter lung structure and function in adult mice...
June 27, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28648794/in%C3%A2-vitro-and-in%C3%A2-vivo-evaluation-of-a-small-caliber-coaxial-electrospun-vascular-graft-loaded-with-heparin-and-vegf
#10
Yun-Tao Hu, Xu-Dong Pan, Jun Zheng, Wei-Guo Ma, Li-Zhong Sun
INTRODUCTION: To date, clinically available expanded polytetrafluoro-ethylene (ePTFE) vascular grafts are suboptimal for reconstructing small caliber (D < 6 mm) arteries, owing to thrombosis in early and restenosis in late stage. Our aim in this preliminary study was to fabricate a nano-fibrous vascular graft which was biofunctionalized with VEGF165 and heparin. The short term performance was evaluated both in vitro and in vivo. METHOD: Four-mm caliber grafts were prepared by the coaxial-elctrospun technique, which consisted of poly(l-lactide-co-caprolactone) [P(LLA-CL)] collagen and elastin...
June 22, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28645116/the-additive-effects-of-the-tm6sf2-e167k-and-pnpla3-i148m-polymorphisms-on-lipid-metabolism
#11
Lizhen Chen, Shuixian Du, Linlin Lu, Zhonghua Lin, Wenwen Jin, Doudou Hu, Xiangjun Jiang, Yongning Xin, Shiying Xuan
There is a genetic susceptibility for nonalcoholic fatty liver disease (NAFLD). To examine the role of genetic factors in the disease, a Bayesian analysis was performed to model gene relationships in NAFLD pathogenesis. The Bayesian analysis indicated a potential gene interaction between the TM6SF2 and PNPLA3 genes. Next, to explore the underlying mechanism at the cellular level, we evaluated the additive effects between the TM6SF2 E167K and PNPLA3 I148M polymorphisms on lipid metabolism. Hepa 1-6 cells were transfected with a control vector or with overexpression vectors for TM6SF2/PNPLA3-wild type, TM6SF2-mutant type, PNPLA3-mutant type, or TM6SF2/PNPLA3-mutant type...
June 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28642009/mice-in-the-early-stage-of-liver-steatosis-caused-by-a-high-fat-diet-are-resistant-to-thioacetamide-induced-hepatotoxicity-and-oxidative-stress
#12
Jaeyong Lee, Takujiro Homma, Junichi Fujii
Lipogenesis is stimulated in the liver by an unfolded protein response (UPR) to endoplasmic reticulum stress under a variety of pathological conditions and results in the accumulation of lipids in hepatocytes. Assuming that UPR is a protective mechanism against stress, we hypothesized that the accumulated lipids might have a beneficial function. We prepared mice with fatty livers by feeding two types of high-calorie diets; a lard-rich high-calorie diet (LHD) or a menhaden oil-containing high-calorie diet (MHD), for two weeks and treated them, as well as control diet (CD)-fed mice, with thioacetamide (TAA), a liver toxicant...
August 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28641918/resistance-of-mice-to-leptospira-infection-and-correlation-with-chemokine-response
#13
R H Domingos, E B Pavanel, E Nakajima, L Schons-Fonseca, R M A Da Costa, M De Franco, E Carvalho, P L Ho, E A Martins, J B Da Silva
Leptospirosis is globally widespread neglected disease, affecting most mammalian species. Clinical signs can be confused with other diseases which make the diagnosis and treatment difficult. Chemokines and cytokines are known for their role in the inflammatory and immune response to infections. The profile determination of chemokines' expressions in the course of infection may elucidate the defense mechanisms of the host and support the search for effective treatment strategies. We investigated the mechanisms of innate immunity through the comparison of chemokines induced during infection with L...
May 26, 2017: Immunobiology
https://www.readbyqxmd.com/read/28609202/the-financial-burden-of-public-health-responses-to-hepatitis-a-cases-among-food-handlers-2012-2014
#14
Rebecca J Morey, Melissa G Collier, Noele P Nelson
When food handlers become ill with hepatitis A virus (HAV) infection, state and local health departments must assess the risk of HAV transmission through prepared food and recommend or provide postexposure prophylaxis (PEP) for those at risk for HAV infection. Providing PEP (eg, hepatitis A [HepA] vaccine or immunoglobulin), however, is costly. To describe the burden of these responses on state and local health departments, we determined the number of public health responses to HAV infections among food handlers by reviewing public internet sources of media articles...
July 2017: Public Health Reports
https://www.readbyqxmd.com/read/28609099/botrysphones-a-c-and-botrysphins-a-f-triketides-and-diterpenoids-from-the-fungus-botrysphaeria-laricina
#15
Peng-Liang Zhang, Yang Han, Long-Teng Zhang, Xiao-Ling Wang, Tao Shen, Dongmei Ren, Hongxiang Lou, Xiao-Ning Wang
Three new triketides, botrysphones A-C (1-3) and six new isopimarane-type diterpenoids, botrysphins A-F (4-9), together with the known triketides sphaeropsidone (10) and chlorosphaeropsidone (11) and diterpenoids sphaeropsidins A and B (12 and 13), were obtained from culture of the fungus Botrysphaeria laricina associated with the moss Rhodobryum umgiganteum. The structures of the new compounds were established on the basis of extensive spectroscopic techniques including HRMS and 1D and 2D NMR data. Compounds 7 and 12 showed significant quinone reductase inducing activity in Hepa 1c1c7 cells...
June 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28598368/self-assembled-lipid-nanoparticles-for-oral-delivery-of-heparin-coated-iron-oxide-nanoparticles-for-theranostic-purposes
#16
Eleonora Truzzi, Chiara Bongio, Francesca Sacchetti, Eleonora Maretti, Monica Montanari, Valentina Iannuccelli, Elena Vismara, Eliana Leo
Recently, solid lipid nanoparticles (SLNs) have attracted increasing attention owing to their potential as an oral delivery system, promoting intestinal absorption in the lymphatic circulation which plays a role in disseminating metastatic cancer cells and infectious agents throughout the body. SLN features can be exploited for the oral delivery of theranostics. Therefore, the aim of this work was to design and characterise self-assembled lipid nanoparticles (SALNs) to encapsulate and stabilise iron oxide nanoparticles non-covalently coated with heparin (Fe@hepa) as a model of a theranostic tool...
June 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28585554/interferon-free-therapy-in-elderly-patients-with-advanced-liver-disease
#17
Sabela Lens, Inmaculada Fernández, Sergio Rodríguez-Tajes, Vanessa Hontangas, Mercedes Vergara, Montserrat Forné, Jose Luis Calleja, Moisés Diago, Jordi Llaneras, Susana Llerena, Xavier Torras, Begoña Sacristán, Merce Roget, Conrado Manuel Fernández-Rodríguez, Mari Carmen Navascués, Javier Fuentes, Juan-José Sánchez-Ruano, Miguel-Ángel Simón, Federico Sáez-Royuela, Carmen Baliellas, Rosa Morillas, Xavier Forns
OBJECTIVES: Interferon-free therapies have an improved safety and efficacy profile. However, data in elderly patients, who have frequently advanced liver disease, associated comorbidities, and use concomitant medications are scarce. The im of this study was to assess the effectiveness and tolerability of all-oral regimens in elderly patients in real-life clinical practice. METHODS: Retrospective analysis of hepatitis C virus (HCV) patients aged ≥65 years receiving interferon-free regimens within the Spanish National Registry (Hepa-C)...
June 6, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28557463/synthesis-of-dual-size-cellulose-polyvinylpyrrolidone-nanofiber-composites-via-one-step-electrospinning-method-for-high-performance-air-filter
#18
Ratna Balgis, Hiroyuki Murata, Yohsuke Goi, Takashi Ogi, Kikuo Okuyama, Li Bao
Dual-size nanofibers consisting of a random mixture of nano- and submicron-size nanofibers are promising structures for specific applications such as air filters because of their increased specific surface area and low pressure drop. Synthesis of dual-size nanofibers using one-step electrospinning was reported here for the first time. The formation of well-mixed nano- and submicron-size cellulose-polyvinylpyrrolidone nanofiber composites was accomplished utilizing the physical properties of TEMPO-oxidized cellulose nanofibers (i...
June 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28455267/metabotropic-glutamate-receptor-5-mediates-the-suppressive-effect-of-6-ohda-induced-model-of-parkinson-s-disease-on-liver-cancer
#19
Shao-Song Xi, Xiao-Xu Bai, Li Gu, Li-Hui Bao, Hui-Min Yang, Wei An, Xiao-Min Wang, Hong Zhang
Numerous epidemiological studies suggested that there is a variable cancer risk in patients with Parkinson's disease (PD). However, the underlying mechanisms remain unclear. In the present study, the role of metabotropic glutamate receptor 5 (mGluR5) has been investigated in 6-hydroxydopamine (6-OHDA)-induced PD combined with liver cancer both in vitro and in vivo. We found that PD cellular model from 6-OHDA-lesioned MN9D cells suppressed the growth, migration, and invasion of Hepa1-6 cells via down-regulation of mGluR5-mediated ERK and Akt pathway...
April 26, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28448436/role-of-archaeal-hera-protein-in-the-biology-of-the-bacterium-thermus-thermophilus
#20
Alba Blesa, Nieves G Quintans, Ignacio Baquedano, Carlos P Mata, José R Castón, José Berenguer
Intense gene flux between prokaryotes result in high percentage of archaeal genes in the genome of the thermophilic bacteria Thermus spp. Among these archaeal genes a homolog to the Sulfolobus spp. HerA protein appears in all of the Thermus spp. strains so far sequenced (HepA). The role of HepA in Thermus thermophilus HB27 has been analyzed using deletion mutants, and its structure resolved at low resolution by electron microscopy. Recombinant HepA shows DNA-dependent ATPase activity and its structure revealed a double ring, conically-shaped hexamer with an upper diameter of 150 Å and a bottom module of 95 Å...
April 27, 2017: Genes
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