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Brian F Leas, Kristen E D'Anci, Andrea J Apter, Tyra Bryant-Stephens, Marcus P Lynch, Janice L Kaczmarek, Craig A Umscheid
BACKGROUND: This review will inform updated National Asthma Education and Prevention Program clinical practice guidelines. OBJECTIVE: To evaluate the effectiveness of allergen reduction interventions on asthma outcomes. METHODS: We systematically searched the gray literature and five bibliographic databases. Eligible studies included systematic reviews, randomized controlled trials, and nonrandomized interventional studies. Risk of bias was assessed using the Cochrane Risk of Bias instrument and the Newcastle-Ottawa scale...
February 13, 2018: Journal of Allergy and Clinical Immunology
Noele P Nelson, David Yankey, James A Singleton, Laurie D Elam-Evans
BACKGROUND: The hepatitis A (HepA) vaccine was recommended by the Advisory Committee on Immunization Practices (ACIP) incrementally from 1996 to 1999. In 2006, HepA vaccine was recommended (1) universally for children aged 12-23 months, (2) for persons who are at increased risk for infection, or (3) for any person wishing to obtain immunity. Catch-up vaccination can be considered. OBJECTIVE: To assess HepA vaccine coverage among adolescents and factors independently associated with vaccination administration in the US...
February 12, 2018: Vaccine
Thomas Nessen, Christina H Opava, Cathrin Martin, Ingrid Demmelmaier
OBJECTIVES: To explore strategies used by physiotherapists (PTs) in guiding people with rheumatoid arthritis to health-enhancing physical activity (HEPA) in a group setting during a 1-year intervention study. METHODS: Exploratory design with qualitative video analysis performed in three steps. Eleven female PTs were video recorded while leading support group sessions aiming at facilitating HEPA (twice-weekly exercise sessions at public gyms and 150 weekly minutes of moderately intense aerobic physical activity)...
February 15, 2018: Physiotherapy Theory and Practice
João Breda, Jelena Jakovljevic, Giulia Rathmes, Romeu Mendes, Olivier Fontaine, Susanne Hollmann, Alfred Rütten, Peter Gelius, Sonja Kahlmeier, Gauden Galea
This study aims to present information on the surveillance, policy developments, and implementation of physical activity policies in the 28 European Union (EU) countries. Data was collected on the implementation of the EU Recommendation on health-enhancing physical activity (HEPA) across sectors. In line with the monitoring framework proposed in the Recommendation, a questionnaire was designed to capture information on 23 physical activity indicators. Of the 27 EU countries that responded to the survey, 22 have implemented actions on more than 10 indicators, four countries have implemented more than 20 indicators, and one country has fully addressed and implemented all of the 23 indicators of the monitoring framework...
February 3, 2018: Health Policy
Doug Brugge, Matthew C Simon, Neelakshi Hudda, Marisa Zellmer, Laura Corlin, Stephanie Cleland, Eda Yiqi Lu, Sonja Rivera, Megan Byrne, Mei Chung, John L Durant
Background: Exposure to airborne ultrafine particle (UFP; <100 nm in aerodynamic diameter) is an emerging public health problem. Nevertheless, the benefit of using high efficiency particulate arrestance (HEPA) filtration to reduce UFP concentrations in homes is not yet clear. Methods: We conducted a randomized crossover study of HEPA filtration without a washout period in 23 homes of low-income Puerto Ricans in Boston and Chelsea, MA (USA). Most participants were female, older adults who were overweight or obese...
December 2017: Building and Environment
Xiaojin Sun, Fuzhen Wang, Hui Zheng, Ning Miao, Qianli Yuan, Fuqiang Cui, Zundong Yin, Guomin Zhang, Hagai Levine
INTRODUCTION: Since 2008, two types of hepatitis A (HepA) vaccines were integrated into the expanded program on immunization (EPI) in China. Children were given either one dose of live attenuated HepA (L-HepA) or two doses of inactivated HepA (I-HepA), depending on geographic regions. We sought to evaluate the impact of the EPI on HepA incidence in China. METHODS: We reviewed the epidemiology of HepA during 2004-2016 from National Notifiable Disease Reporting System (NNDRS)...
February 1, 2018: Vaccine
Xin Yue, Carla L Black, Alissa O'Halloran, Peng-Jun Lu, Walter W Williams, Noele P Nelson
BACKGROUND: Infection with hepatitis A and hepatitis B virus can increase the risk of morbidity and mortality in persons with chronic liver disease (CLD). The Advisory Committee on Immunization Practices recommends hepatitis A (HepA) and hepatitis B (HepB) vaccination for persons with CLD. METHODS: Data from the 2014 and 2015 National Health Interview Surveys (NHIS), nationally representative, in-person interview surveys of the non-institutionalized US civilian population, were used to assess self-reported HepA (≥1 and ≥2 doses) and HepB vaccination (≥1 and ≥3 doses) coverage among adults who reported a chronic or long-term liver condition...
February 21, 2018: Vaccine
Byeong Suk Chae
Pretreatment of low-dose lipopolysaccharide (LPS) induces a hyporesponsive state to subsequent secondary challenge with high-dose LPS in innate immune cells, whereas super-low-dose LPS results in augmented expression of pro-inflammatory cytokines. However, little is known about the difference between super-low-dose and low-dose LPS pretreatments on immune cell-mediated inflammatory and hepatic acute-phase responses to secondary LPS. In the present study, RAW 264.7 cells, EL4 cells, and Hepa-1c1c7 cells were pretreated with super-low-dose LPS (SL-LPS: 50 pg/mL) or low-dose LPS (L-LPS: 50 ng/mL) in fresh complete medium once a day for 2~3 days and then cultured in fresh complete medium for 24 hr or 48 hr in the presence or absence of LPS (1~10 μg/mL) or concanavalin A (Con A)...
January 2018: Toxicological Research
Ahmet Deniz, Ömer Lütfi Erhan, Mustafa Kemal Bayar, Ümit Karatepe, İsmail Demirel
Objective: This retrospective study aimed to evaluate the effect of a restructured anaesthesia intensive care unit (ICU) on changes in infection rates and infections. Methods: Organisational restructuring was done in the anaesthesia ICU of Firat University Hospital after it was relocated on 14 March 2012. This study was designed to investigate the effect of restructuring on infection rates through a comparison of periods encompassing one year before relocation and one year after relocation...
December 2017: Turkish Journal of Anaesthesiology and Reanimation
Junko Enomoto, Tatsuto Kageyama, Dina Myasnikova, Kisaki Onishi, Yuka Kobayashi, Yoko Taruno, Takahiro Kanai, Junji Fukuda
Self-assembled monolayers (SAMs) have been used to elucidate interactions between cells and material surface chemistry. Gold surfaces modified with oligopeptide SAMs exhibit several unique characteristics, such as cell-repulsive surfaces, micropatterns of cell adhesion and non-adhesion regions for control over cell microenvironments, and dynamic release of cells upon external stimuli under culture conditions. However, basic procedures for the preparation of oligopeptide SAMs, including appropriate cleaning methods of the gold surface before modification, have not been fully established...
January 15, 2018: Journal of Bioscience and Bioengineering
Drew B Day, Jianbang Xiang, Jinhan Mo, Merlise A Clyde, Charles J Weschler, Feng Li, Jicheng Gong, Mingkei Chung, Yinping Zhang, Junfeng Jim Zhang
HEPA filtration in combination with an electrostatic precipitator (ESP) can be a cost-effective approach to reducing indoor particulate exposure, but ESPs produce ozone. The health effect of combined ESP-HEPA filtration has not been examined. We conducted an intervention study in 89 volunteers. At baseline, the air handling units of offices and residences for all subjects were comprised of coarse, ESP, and HEPA filtration. During the 5-week long intervention, the subjects were split into two groups, one with just the ESP removed and the other with both the ESP and HEPA removed...
December 29, 2017: Indoor Air
Derek A Newcomer, Peter LaPuma, Robert Brandys, Amanda Northcross
The portable high efficiency air filtration (PHEAF) device is used to control particulate matter (PM) generated from construction-type activities occurring within the built environment. Examples of activities where PHEAF devices are mobilized include building renovation, asbestos abatement, remediation of microbial contamination and lead-based paint projects. Designed for use on short-term, temporary projects the PHEAF device captures airborne PM using a high efficiency particulate air (HEPA) filter. This study sought to evaluate the capture efficiency of the PHEAF device in a field setting...
December 29, 2017: Journal of Occupational and Environmental Hygiene
Ingrid Babinská, Monika Halánová, Zuzana Kalinová, Lenka Čechová, Lýdia Čisláková, Andrea Madarasová Gecková
The aim of the study was to explore sexual behaviour and the occurrence of Chlamydia trachomatis (CT) infection in the population living in Roma settlements compared to the majority population in Slovakia and to assess the association between alcohol use and sexual behaviour within both populations. A cross-sectional population-based Hepa-Meta study was conducted in Slovakia in 2011. The final sample comprised 452 Roma and 403 non-Roma respondents. The occurrence of CT was detected by direct proof of the pathogen by PCR...
December 14, 2017: International Journal of Environmental Research and Public Health
Liuyi Hao, Qian Sun, Wei Zhong, Wenliang Zhang, Xinguo Sun, Zhanxiang Zhou
Alcohol metabolism in the liver generates highly toxic acetaldehyde. Breakdown of acetaldehyde by aldehyde dehydrogenase 2 (ALDH2) in the mitochondria consumes NAD(+) and generates reactive oxygen/nitrogen species, which represents a fundamental mechanism in the pathogenesis of alcoholic liver disease (ALD). A mitochondria-targeted lipophilic ubiquinone (MitoQ) has been shown to confer greater protection against oxidative damage in the mitochondria compared to untargeted antioxidants. The present study aimed to investigate if MitoQ could preserve mitochondrial ALDH2 activity and speed up acetaldehyde clearance, thereby protects against ALD...
November 11, 2017: Redox Biology
Mohamed Alboraie, Kerstin Schütte, Marwa Khairy, Marwa Elsharkawy, Noha Asem, Fathy Elghamry, Helmy Shalaby, Gamal Esmat, Peter Malfertheiner
To validate the diagnostic performance of Hepa-Index in predicting different stages of hepatic fibrosis in Egyptian patients with chronic hepatitis C (CHC). Methods: Hundred treatment naïve chronic hepatitis C Egyptian patients were prospectively enrolled between June 2014 and January 2015. They were subjected to: platelet count, alpha-2-macroglobulin (α2-MG), total bilirubin, gamma glutamyl transpeptidase (GGT), total cholesterol, liver biopsy and histopathological staging of hepatic fibrosis according to METAVIR scoring system...
November 2017: Saudi Medical Journal
Mu-Qing Yang, Qiang Du, Patrick R Varley, Julie Goswami, Zhihai Liang, Ronghua Wang, Hui Li, Donna B Stolz, David A Geller
BACKGROUND: Tumour-derived exosomes (TEXs) have a potential for application in cancer vaccines. Whether TEXs after induction by interferon regulatory factor 1 (IRF-1) are capable of enhancing the antitumour response remains to be determined. METHODS: Exosomes released by tumour cells infected with IRF-1-expressing adenovirus (IRF-1-Exo) or treated with interferon-γ (IFN-Exo) were isolated via ultracentrifugation. The IRF-1 target proteins IL-15Rα and MHC class I (MHC-I) were analysed by western blot...
November 7, 2017: British Journal of Cancer
Juan Felipe Combariza, Luis Fernando Toro, John Jairo Orozco, Marcos Arango
OBJECTIVES: Invasive Aspergillosis (IA) is a serious problem among hematological patients and it is associated with high mortality. This situation can worsen at times of hospital construction, however there are several preventive measures available. This work aims to define the cost-effectiveness of some of these interventions. PATIENTS AND METHODS: A decision tree model was used, it was divided into four arms according to each one of the interventions performed...
November 6, 2017: European Journal of Haematology
Chu-Chun Chien, Yuan-Horng Yan, Hung-Tzu Juan, Tsun-Jen Cheng, Jia-Bin Liao, Huai-Pao Lee, Jyh-Seng Wang
Exposure to zinc oxide (ZnO) has been linked to adverse health effects, but the renal effects of ZnO nanoparticles (ZnONPs) remain unclear. The objective of this study was to determine the renal toxicity of inhaled ZnONPs. Sprague Dawley (SD) rats were exposed to occupationally relevant levels of 1.1 (low dose) and 4.9 mg/m(3) (high dose) ZnONPs or high-efficiency particulate arresting-filtered air (HEPA-FA) via inhalation for 2 weeks. Histopathological examinations of rat kidneys were performed at 24 hours, 7 days, and 1 month after exposure...
October 2017: Journal of Toxicologic Pathology
Bora Shin, So Hyun Park, Byung-Yong Kim, Shin-Il Jo, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
Four new aminoglycolipids, deinococcucins A-D (1-4), were discovered from a Deinococcus sp. strain isolated from the gut of queen carpenter ants, Camponotus japonicus. The structures of deinococcucins A-D were elucidated as a combination of N-acetyl glucosamine, 2,3-dihydroxypropanoic acid, and an alkyl amine with a C16 or C17 hydrocarbon chain primarily based on 1D and 2D NMR and mass spectroscopic data. The exact location of the olefinic double bond in deinococcucins C and D (3 and 4) was assigned based on the liquid chromatography-mass spectroscopy data obtained after olefin metathesis...
November 1, 2017: Journal of Natural Products
Jaeyong Lee, Eun Sil Kang, Sho Kobayashi, Takujiro Homma, Hideyo Sato, Han Geuk Seo, Junichi Fujii
Extracellular cystine, the oxidized form of cysteine (Cys), is taken up by cells via the cystine transporter xCT. xCT is not expressed in the liver but is induced in primary hepatocytes under conventional cultured conditions. However, compared to wild-type hepatocytes those from the xCT-knockout mouse showed no evidence of an abnormality and the levels of both Cys and glutathione (GSH) remained unchanged. The levels of ophthalmic acid (OPT), which is produced as an alternative compound by the GSH-synthesizing pathway, became increased during the culturing of hepatocytes...
October 26, 2017: Experimental Cell Research
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