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https://www.readbyqxmd.com/read/28448436/role-of-archaeal-hera-protein-in-the-biology-of-the-bacterium-thermus-thermophilus
#1
Alba Blesa, Nieves G Quintans, Ignacio Baquedano, Carlos P Mata, José R Castón, José Berenguer
Intense gene flux between prokaryotes result in high percentage of archaeal genes in the genome of the thermophilic bacteria Thermus spp. Among these archaeal genes a homolog to the Sulfolobus spp. HerA protein appears in all of the Thermus spp. strains so far sequenced (HepA). The role of HepA in Thermus thermophilus HB27 has been analyzed using deletion mutants, and its structure resolved at low resolution by electron microscopy. Recombinant HepA shows DNA-dependent ATPase activity and its structure revealed a double ring, conically-shaped hexamer with an upper diameter of 150 Å and a bottom module of 95 Å...
April 27, 2017: Genes
https://www.readbyqxmd.com/read/28417612/fatigue-and-its-relationship-to-physical-activity-in-adolescents-and-young-adults-with-traumatic-brain-injury-a-cross-sectional-study
#2
Frederike van Markus-Doornbosch, Jorit Meesters, Laurika Kraaij, Ron Wolterbeek, Thea Vliet Vlieland
BACKGROUND: Physical activity (PA) in patients with traumatic brain injury (TBI) may be impaired leading to secondary health issues and limitations in participation. AIM: This study aims to determine the level of PA and its determinants in adolescents and young adults with TBI. DESIGN: Cross-sectional survey study. SETTING: Outpatient clinic of a rehabilitation centre. POPULATION: Discharged patients aged 12-39 years with a diagnosis of TBI >6 months treated in the rehabilitation centre between 2009-2012...
April 14, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28412617/selection-of-optimized-air-pollutant-filtration-technologies-for-petrochemical-industries-through-multiple-attribute-decision-making
#3
Parvin Moridi, Farideh Atabi, Jafar Nouri, Rasoul Yarahmadi
Selecting cost-effective and efficient air filtration technologies that ensure sustainable development is a challenge to national, regional and local policy makers. Various factors such as efficiency, maintainability, and design of the developed devices can affect the selection of optimized technologies. The present study aimed to select optimal technologies for air filtration devices in petrochemical industries through a multi-criteria decision-making (MADM) method based on a fuzzy model of Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS)...
April 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28407767/e167k-polymorphism-of-tm6sf2-gene-affects-cell-cycle-of-hepatocellular-carcinoma-cell-hepa-1-6
#4
Shuixian Du, Linlin Lu, Yingxia Miao, Wenwen Jin, Changfei Li, Yongning Xin, Shiying Xuan
BACKGROUND: Some studties reported that the polymorphism of TM6SF2 gene E167K affects the occurrence and the progression of hepatocytes carcinoma (hepatocellular, HCC). In oeder to investigate the effects of the polymorphism of TM6SF2 gene E167K in the pathogenesis of HCC, we explored its influence on the cell cycle in hepatocellular carcinoma cell HEPA1-6. METHODS: HEPA 1-6 cells which could respectively overexpress TM6SF2 wild type and E167K variant were cultured and HEPA 1-6 cells with zero load plasmids were used as matched control...
April 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28406362/evaluation-of-coverall-field-dry-aerosol-decontamination-methods-using-a-manikin
#5
J M Slagley, H Paschold, J M Engler
A full-size manikin dressed in fire-resistant coveralls coated in 120 grams of sodium bicarbonate was randomly given one of three treatments for dry aerosol decontamination. The three treatments were high-efficiency particulate air (HEPA) vacuum, a commercially-available air shower, and the no treatment control. Immediately after the treatment, the coveralls were doffed and an air sample was taken in the breathing zone of the manikin to estimate airborne total and respirable dust concentrations to an unprotected worker post decontamination...
April 13, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28399860/the-chinese-medicine-jc-001-enhances-the-chemosensitivity-of-lewis-lung-tumors-to-cisplatin-by-modulating-the-immune-response
#6
Meng-Hsien Chuang, Ming-Shiou Jan, Jinghua Tsai Chang, Fung-Jou Lu
BACKGROUND: JC-001 is a Chinese medicine that can modulate the immunity in Hepa 1-6 tumor-bearing mice, and we questioned whether JC-001 can serve as efficient adjuvant chemotherapy. We aimed to identify a novel approach for enhancing cis-diamminedichloroplatinum (II) (CDDP)-based chemotherapy by immunomodulation. METHODS: The anti-tumor activity in vitro was determined based on foci formation and a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
April 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28389537/airborne-pathogens-inside-automobiles-for-domestic-use-assessing-in-car-air-decontamination-devices-using-staphylococcus-aureus-as-the-challenge
#7
Syed A Sattar, Bahram Zargar, Kathryn E Wright, Joseph R Rubino, M Khalid Ijaz
Family cars represent ∼74% of the yearly global output of motorized vehicles. With the life-expectancy of ∼8 decades in many countries, one spends >100 minutes daily inside the confined and often shared space of the car with exposure to a mix of potentially harmful microbes. Can commercial in-car air microbial decontamination devices mitigate the risk? Three such devices (designated as Device #s1-3) with HEPA filters were tested in the modified passenger cabin (3.25 m3) of a four-door sedan housed within a biosafety level 3 containment facility...
April 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28383761/endoplasmic-reticulum-stress-in-mice-increases-hepatic-expression-of-genes-carrying-a-premature-termination-codon-via-a-nutritional-status-independent-grp78-dependent-mechanism
#8
Nagakatsu Harada, Maiko Okuyama, Aya Yoshikatsu, Hironori Yamamoto, Saori Ishiwata, Chikako Hamada, Tomoyo Hirose, Masayuki Shono, Masashi Kuroda, Rie Tsutsumi, Jiro Takeo, Yutaka Taketani, Yutaka Nakaya, Hiroshi Sakaue
Nonsense-mediated mRNA decay (NMD) degrades mRNAs carrying a premature termination codon (PTC) in eukaryotes. Cellular stresses, including endoplasmic reticulum (ER) stress, inhibit NMD and up-regulate PTC-containing mRNA (PTC-mRNA) levels in several cell lines. However, whether similar effects exist under in vivo conditions that involve systemic nutritional status is unclear. Here we compared the effects of pharmacological induction of ER stress with those of nutritional interventions on hepatic PTC-mRNA levels in mice...
April 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28327529/mass-spectrometric-characteristics-of-prenylated-indole-derivatives-from-marine-derived-penicillium-sp-nh-sl
#9
Hui Ding, Wanjing Ding, Zhongjun Ma
Two prenylated indole alkaloids were isolated from the ethyl acetate extracts of a marine-derived fungus Penicillium sp. NH-SL and one of them exhibited potent cytotoxic activity against mouse hepa 1c1c7 cells. In order to detect other bioactive analogs, we used liquid chromatogram tandem mass spectrometry (LC-MS/MS) to analyze the mass spectrometric characteristics of the isolated compounds as well as the crude extracts. As a result, three other analogs were detected, and their structures were deduced according to the similar fragmentation patterns...
March 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28289825/the-highly-bioactive-molecule-and-signal-substance-6-formylindolo-3-2-b-carbazole-ficz-plays-bi-functional-roles-in-cell-growth-and-apoptosis-in-vitro
#10
Afshin Mohammadi-Bardbori, Farzaneh Bastan, Amin-Reza Akbarizadeh
The maintenance of cellular homeostasis is a complex process that is governed by the receipt of prototypical growth and death signals. The endogenous functions of aryl hydrocarbon receptor (AHR) in cellular homeostasis are not well understood. We aimed to establish whether the disturbance of endogenously activated AHR can influence cell growth, and if so, what mechanism(s) are involved. Cell growth was measured in mouse hepatoma Hepa-1 wild-type and cytochrome P4501A1 (CYP1A1)-deficient c37 cells. In other sets of experiments, HepG2 cells were exposed to different doses of FICZ (0...
March 13, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28274955/physical-activity-in-adults-with-congenital-heart-disease-and-associations-with-functional-outcomes
#11
Jan Müller, Tamara Amberger, Anika Berg, Daniel Goeder, Julia Remmele, Renate Oberhoffer, Peter Ewert, Alfred Hager
OBJECTIVE: Improved survival has yielded to growing importance of functional outcome measures in patients with congenital heart disease (CHD). This study applied the International Physical Activity Questionnaire (IPAQ) to assess self-reported physical activity (PA) in patients with CHD and their association with exercise capacity and health-related quality of life (HrQoL). PATIENTS AND METHODS: Prior to cardiopulmonary exercise testing (CPET), 786 consecutive patients (335 female, 31...
March 8, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28254663/anti-tumorigenic-and-anti-angiogenic-effects-of-natural-conifer-abies-sibirica-terpenoids-in-vivo-and-in-vitro
#12
Yulia A Nevzorova, Johannes Grossmann, Christian Trautwein
AIM: The natural terpenoid compound was explored in vitro and in vivo to investigate the anti-HCC properties. METHODS: For our study we used Abisilin(®)- a novel natural pharmacological terpenoid compound extracted and purified from coniferous Pinaceae trees. Anti-tumorigenic properties of different concentrations of Abisilin(®) were tested on murine hepatoma Hepa 1-6 cell lines. The analysis of proliferation and apoptosis was performed using immunofluorescence microscopy, FACS and qPCR...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28198173/delphi-based-study-and-analysis-of-key-risk-factors-for-invasive-fungal-infection-in-haematological-patients
#13
L Vázquez, M Salavert, J Gayoso, M Lizasoaín, I Ruiz Camps, N Di Benedetto
OBJECTIVE: Mortality caused by invasive fungal infections due to filamentous fungi (IFI-FF) is high. Predisposing factors to IFI-FF are multiple and should be stratified. The objective of this study was to identify key risk factors for IFI-FF in onco-haematological patients in different clinical settings. METHODS: Prospective national Delphi study. Risk factors for IFI-FF in patients with onco-haematological diseases were identified by a systematic review of the literature...
April 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28179033/emergency-evacuation-of-immunocompromised-patients-from-a-hematology-unit-following-flooding-of-high-efficiency-particulate-air-hepa-filtration
#14
Philippe Saliou, Jean-Christophe Ianotto, Marie-Anne Couturier, Gaëlle Guillerm, Hervé Le Bars, Dorothée Quinio, Solène Le Gal, Raoul Baron
No abstract text is available yet for this article.
February 9, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28170112/treatment-of-hepatitis-c-virus-infection-in-patients-with-cirrhosis-and-predictive-value-of-meld-analysis-of-data-from-the-hepa-c-registry
#15
Carlos Fernández Carrillo, Sabela Lens, Elba Llop, Juan Manuel Pascasio, Javier Crespo, Juan Arenas, Inmaculada Fernández, Carme Baliellas, José Antonio Carrión, Manuel de la Mata, Maria Buti, Lluís Castells, Agustín Albillos, Manuel Romero, Juan Turnes, Clara Pons, José María Moreno-Planas, José Javier Moreno-Palomares, Conrado Fernández-Rodriguez, Javier García-Samaniego, Martín Prieto, Miguel Fernández Bermejo, Javier Salmerón, Ester Badia, Magdalena Salcedo, José Ignacio Herrero, Rafael Granados, Michel Blé, Zoe Mariño, José Luis Calleja
Direct-acting antiviral agents (DAAs) are highly effective and well tolerated in patients with chronic hepatitis C virus (HCV) infection, including those with compensated cirrhosis. However, fewer data are available in patients with more advanced liver disease. Our retrospective, non-interventional, national, multi-center study in patients from the Spanish Hepa-C registry investigated the effectiveness and safety of interferon-free DAA regimens in patients with advanced liver disease, including those with decompensated cirrhosis, in routine practice (all currently approved regimens were registered)...
February 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28170103/effectiveness-and-cost-of-reducing-particle-related-mortality-with-particle-filtration
#16
William J Fisk, Wanyu R Chan
This paper evaluates the mortality-related benefits and costs of improvements in particle filtration in U.S. homes and commercial buildings based on models with empirical inputs. The models account for time spent in various environments as well as activity levels and associated breathing rates. The scenarios evaluated include improvements in filter efficiencies in both forced air heating and cooling systems of homes and heating, ventilating, and air conditioning systems of workplaces as well as use of portable air cleaners in homes...
February 7, 2017: Indoor Air
https://www.readbyqxmd.com/read/28159008/unravelling-networks-in-local-public-health-policymaking-in-three-european-countries-a-systems-analysis
#17
Hilde P E M Spitters, Cathrine J Lau, Petru Sandu, Marcel Quanjel, Diana Dulf, Charlotte Glümer, Hans A M van Oers, Ien A M van de Goor
BACKGROUND: Facilitating and enhancing interaction between stakeholders involved in the policymaking process to stimulate collaboration and use of evidence, is important to foster the development of effective Health Enhancing Physical Activity (HEPA) policies. Performing an analysis of real-world policymaking processes will help reveal the complexity of a network of stakeholders. Therefore, the main objectives were to unravel the stakeholder network in the policy process by conducting three systems analyses, and to increase insight into the similarities and differences in the policy processes of these European country cases...
February 3, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28122519/health-enhancing-physical-activity-in-patients-with-hip-or-knee-osteoarthritis-an-observational-intervention-study
#18
Anna Ernstgård, MirNabi PirouziFard, Carina A Thorstensson
BACKGROUND: Osteoarthritis is one of the leading causes of inactivity worldwide. The recommended level of health enhancing physical activity (HEPA) is at least 150 min of moderate intensity physical activity per week. The purpose of this study was to explore how the proportion of patients, who reached the recommended level of HEPA, changed following a supported osteoarthritis self-management programme in primary care, and to explore how reaching the level of HEPA was influenced by body mass index (BMI), gender, age and comorbidity...
January 25, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28098898/a-hepatic-stem-cell-vaccine-is-superior-to-an-embryonic-stem-cell-vaccine-in-the-prophylaxis-and-treatment-of-murine-hepatocarcinoma
#19
Qi Zheng, Yichao Zheng, Jing Chen, Jia You, Yueyong Zhu, Yurui Liu, Jia Ji Jiang
Stem cells and cancer cells express a common subset of antigens called oncofetal antigens. Theoretically, vaccination with stem cells is effective at boosting the preexisting anticancer immune response. Herein we describe the efficacy of two stem cell-based vaccines in the prophylaxis and treatment of subcutaneous hepatic tumors transplanted into mice. C57BL/6j mice were vaccinated weekly with either hepatic stem cells (HSCs) or embryonic stem cells (ESCs) for three weeks, followed by a subcutaneous challenge with Hepa 1-6 cells at one week (group 1) or four weeks (group 2) after vaccination...
January 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28089593/physician-knowledge-and-attitudes-about-hepatitis-a-and-current-practices-regarding-hepatitis-a-vaccination-delivery
#20
Noele P Nelson, Mandy Allison, Megan C Lindley, Michaela Brtnikova, Lori A Crane, Brenda L Beaty, Laura P Hurley, Allison Kempe
OBJECTIVES: To assess physicians' 1) knowledge and attitudes about hepatitis A disease and HepA vaccine, and 2) child care and school HepA vaccine mandates; 3) practices related to HepA vaccine delivery; 4) factors associated with strongly recommending HepA vaccine to all 1-2 year olds; and 5) feasibility of implementing HepA catch-up vaccination at health maintenance visits. METHODS: A national survey was conducted among representative networks of pediatricians and family medicine physicians (FMs) from March to June, 2014 by e-mail or mail based on provider preference...
January 9, 2017: Academic Pediatrics
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