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https://www.readbyqxmd.com/read/29660515/aspergillus-fumigatus-viability-drives-allergic-responses-to-inhaled-conidia
#1
Ajay P Nayak, Tara L Croston, Angela R Lemons, W T Goldsmith, Nikki B Marshall, Michael L Kashon, Dori R Germolec, Donald H Beezhold, Brett J Green
BACKGROUND: Aspergillus fumigatus induced allergic airway disease has been shown to involve conidial germination in vivo but the immunological mechanisms remain uncharacterized. OBJECTIVE: A subchronic murine exposure model was used to examine the immunological mediators that are regulated in response to either culturable or non-culturable A. fumigatus conidia. METHODS: Female B6C3F1/N mice were repeatedly dosed via inhalation with 1 x 105 viable or heat inactivated conidia (HIC), twice a week for 13 weeks (26 exposures)...
April 13, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29653076/e4bp4-regulates-carboxylesterase-2-enzymes-through-repression-of-the-nuclear-receptor-rev-erb%C3%AE-in-mice
#2
Mengjing Zhao, Tianpeng Zhang, Fangjun Yu, Lianxia Guo, Baojian Wu
Carboxylesterases (CES) are a family of phase I enzymes that plays an important role in xenobiotic clearance and lipid metabolism. Here, we investigate a potential role of E4 promoter-binding protein 4 (E4bp4) in regulation of Ces and CPT-11 (irinotecan, a first-line drug for treating colorectal cancer) pharmacokinetics in mice. Mouse hepatoma Hepa-1c1c7 cells were transfected with Rev-erbα expression plasmid or siRNA targeting E4bp4. The relative mRNA and protein levels of Ces enzymes in the cells or the livers of wild-type and E4bp4-deficient (E4bp4-/- ) mice were determined by qPCR and Western blotting, respectively...
April 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29642834/-risk-of-travel-associated-tuberculosis
#3
Süheyla Sürücüoğlu
Tuberculosis has spread by human movements throughout history. There have been reports indicating tuberculosis transmission on all travel vehicles, including aircrafts, ground vehicles and vessels until today. However, due to the ever increasing of air transportation and air travelling among countries with low and high tuberculosis incidence, transmission risk especially in aircrafts has become an important issue worldwide. But in many of the studies conducted in this regard, transmission of tuberculosis in aircrafts was found very low...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29624906/stress-effects-of-cyanotoxin-%C3%AE-methylamino-l-alanine-bmaa-on-cyanobacterial-heterocyst-formation-and-functionality
#4
Alexandra A Popova, Ulla Rasmussen, Tatiana A Semashko, Vadim M Govorun, Olga A Koksharova
Various species of cyanobacteria, diatoms and dinoflagellates are capable of synthesizing the non-proteinogenic neurotoxic amino acid β-N-methylamino-L-alanine (BMAA), which is known to be a causative agent of human neurodegeneration. Similar to most cyanotoxins, the biological and ecological functions of BMAA in cyanobacteria are unknown. In this study, we show for the first time that BMAA, in micromolar amounts, inhibits the formation of heterocysts (specialized nitrogen-fixing cells) in heterocystous, diazotrophic cyanobacteria (Anabaena sp...
April 6, 2018: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29572038/high-efficiency-particulate-air-filters-do-not-affect-acute-infection-rates-during-primary-total-joint-arthroplasty-using-forced-air-warmers
#5
Gannon L Curtis, Mhamad Faour, Jaiben George, Alison K Klika, Wael K Barsoum, Carlos A Higuera
BACKGROUND: Studies have suggested that forced-air warmers (FAWs) increase contamination of the surgical site. In response, FAWs with high efficiency particulate air filters (FAW-HEPA) were introduced. This study compared infection rates following primary total joint arthroplasty (TJA) using FAW and FAW-HEPA. METHODS: Primary TJA patients at a single healthcare system were retrospectively reviewed. A total of 5405 THA (n = 2419) and TKA (n = 2986) consecutive cases in 2013 and 2015 were identified...
February 5, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29569261/activity-guided-isolation-of-phase-ii-enzyme-inducers-from-buckwheat-flour-methanolic-extracts
#6
Rongying Qiu, Junru Wang, Kirk L Parkin
BACKGROUND: Buckwheat is an important alternative crop and raw material for functional food formulation. Phase II detoxification proteins/enzymes provide cytoprotective roles against oxidative stress and inflammation originating from various stressors. We sought to identify and characterize potential phase II enzyme inducers from methanolic extracts of buckwheat flour, using an activity-guided fractionation based on the induction of quinone reductase (QR, E.C. 1.6.5.2) in Hepa 1c1c7 cells...
March 22, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29549698/efficacy-of-air-purifier-therapy-in-allergic-rhinitis
#7
Luo Jia-Ying, Chen Zhao, Guo Jia-Jun, Guo Zi-Jun, Lan Xiao, Sun Bao-Qing
BACKGROUND: With the rising prevalence of allergic rhinitis, the utility of indoor environmental management deserves increasing scrutiny. This research aims at evaluating the ability of air purifiers to be a therapy of allergic rhinitis. METHODS: 32 subjects (25±13.5 years old) diagnosed with allergic rhinitis were selected and HEPA air purifiers placed in their bedrooms for 4 months. Before the intervention and each month, dust samples were collected with a vacuum cleaner and the dust collector assessed for allergen content...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29545617/evaluation-of-the-selective-toxic-effect-of-the-charge-switchable-diethyldithiocarbamate-loaded-nanoparticles-between-hepatic-normal-and-cancerous-cells
#8
Marwa M Abu-Serie
Liver cancer is mainly originated by cancer stem cells (CSCs). Due to difference in pH between normal and tumor cell microenvironments, targeting hepatic CSCs exploiting pH-dependent charge switchable nanoparticles (NPs) is extremely required to limit nonselective toxicity to normal hepatocytes (NHCs) and to completely eliminate the root of cancer origin. In this study, NPs were prepared from cationic chitosan and then coated with anionic albumin namely uncoated and coated NPs, respectively. Both NPs were loaded with diethyldithiocarbamate (DDC) which is an inhibitor of the critical enzyme, aldehyde dehydrogenase (ALDH) 1A1, for CSCs survival...
March 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29541427/effect-of-genistein-on-apoptosis-and-proliferation-of-hepatocellular-carcinoma-hepa1-6-cell-line
#9
Masumeh Sanaei, Fraidoon Kavoosi, Ali Valiani, Mohamed Amin Ghobadifar
Background: One of the main causes of mortality is hepatocellular carcinoma (HCC) which accounts for the third leading cause of deaths and one in forty deaths worldwide. The flavonoids, natural antioxidant compounds, account for a major group of polyphenolic compounds. One of the major isoflavones in soybean is genistein (GE) which can inhibit proliferation and induce apoptosis. Isoflavones, major type of phenolic materials, derived from dietary plants and medicinal herbs play a significant role in cancer prevention and treatment...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29535381/protective-environment-for-hematopoietic-cell-transplant-hsct-recipients-the-infectious-diseases-working-party-ebmt-analysis-of-global-recommendations-on-health-care-facilities
#10
Jan Styczynski, Gloria Tridello, J Peter Donnelly, Simona Iacobelli, Jennifer Hoek, Malgorzata Mikulska, Mahmoud Aljurf, Lidia Gil, Simone Cesaro
International guidelines on protective environment for HSCT recipients proposed a set of 10 global recommendations in 2009 on protective environment (GRPE) concerning hospital room design and ventilation. The EBMT Infectious Diseases Working Party undertook a survey on the status on protective environment for HSCT recipients with the aim of surveying current practices and their agreement with GRPE recommendations. The questionnaire consisted of 37 questions divided into 5 sections about filtration, air changes, maintenance, and the protective environment in rooms and the surrounding unit...
March 13, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29496489/xenobiotic-metabolism-in-the-fish-hepatic-cell-lines-hepa-e1-and-rth-149-and-the-gill-cell-lines-rtgill-w1-and-g1b-biomarkers-of-cyp450-activity-and-oxidative-stress
#11
Marco E Franco, Grace E Sutherland, Ramon Lavado
The use of fish cell cultures has proven to be an effective tool in the study of environmental and aquatic toxicology. Valuable information can be obtained from comparisons between cell lines from different species and organs. In the present study, specific chemicals were used and biomarkers (e.g. 7-Ethoxyresorufin-O-deethylase (EROD) activity and reactive oxygen species (ROS)) were measured to assess the metabolic capabilities and cytotoxicity of the fish hepatic cell lines Hepa-E1 and RTH-149, and the fish gill cell lines RTgill-W1 and G1B...
February 26, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29491439/-cyclical-bias-in-microbiome-research-revealed-by-a-portable-germ-free-housing-system-using-nested-isolation
#12
Alexander Rodriguez-Palacios, Natalia Aladyshkina, Jessica C Ezeji, Hailey L Erkkila, Mathew Conger, John Ward, Joshua Webster, Fabio Cominelli
Germ-Free (GF) research has required highly technical pressurized HEPA-ventilation anchored systems for decades. Herein, we validated a GF system that can be easily implemented and portable using Nested Isolation (NesTiso). GF-standards can be achieved housing mice in non-HEPA-static cages, which only need to be nested 'one-cage-inside-another' resembling 'Russian dolls'. After 2 years of monitoring ~100,000 GF-mouse-days, NesTiso showed mice can be maintained GF for life (>1.3 years), with low animal daily-contamination-probability risk (1 every 867 days), allowing the expansion of GF research with unprecedented freedom and mobility...
February 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29476946/development-of-an-approach-to-correcting-micropem-baseline-drift
#13
Ting Zhang, Steven N Chillrud, Masha Pitiranggon, James Ross, Junfeng Ji, Beizhan Yan
BACKGROUND: Fine particulate matter (PM2.5 ) is associated with various adverse health outcomes. The MicroPEM (RTI, NC), a miniaturized real-time portable particulate sensor with an integrated filter for collecting particles, has been widely used for personal PM2.5 exposure assessment. Five-day deployments were targeted on a total of 142 deployments (personal or residential) to obtain real-time PM2.5 levels from children living in New York City and Baltimore. Among these 142 deployments, 79 applied high-efficiency particulate air (HEPA) filters in the field at the beginning and end of each deployment to adjust the zero level of the nephelometer...
February 21, 2018: Environmental Research
https://www.readbyqxmd.com/read/29474812/inactivation-of-filter-bound-aerosolized-ms2-bacteriophages-using-a-non-conductive-ultrasound-transducer
#14
Michael Versoza, Wonseok Jung, Mona Loraine Barabad, Yongil Lee, Kyomin Choi, Duckshin Park
The inactivation of viruses that retain their infectivity when transmitted through the air is challenging. To address this issue, this study used a non-contact ultrasound transducer (NCUT) to generate shock waves in the air at specific distances, input voltages, and exposure durations, targeting bacteriophage virus aerosols captured on to H14 HEPA filters. Initially, a frequency of 27.56 kHz (50V) at 25-mm distance was used, which yielded an inactivation efficiency of up to 32.69 ± 12.10%. Other frequencies at shorter distances were investigated, where 29...
February 20, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29464863/change-in-alt-levels-after-administration-of-hmg-coa-reductase-inhibitors-to-subjects-with-pretreatment-levels-three-times-the-upper-normal-limit-in-clinical-practice
#15
Hyunah Kim, Hyeseon Lee, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
AIM: Prescription of statins to patients with chronic liver disease whose alanine transaminase (ALT) is over three times the upper normal limit (UNL) is not recommended. In this study, we attempted to evaluate patients with baseline ALT levels > 3 × UNL who were prescribed statins without ethical problems, using electronic medical records. METHODS: We enrolled subjects with ALT levels > 3 × UNL. The patients were divided into three groups consisting of those who had been taking agents affecting liver function (HEPA) and continued to do so after the statin prescription (HepCon), those who had not previously taken HEPA and began doing so after statin prescription (HepNew), and those who had never taken HEPA (HepNo)...
February 21, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29452202/effectiveness-of-indoor-allergen-reduction-in-the-management-of-asthma-a-systematic-review
#16
Brian F Leas, Kristen E D'Anci, Andrea J Apter, Tyra Bryant-Stephens, Marcus P Lynch, Janice L Kaczmarek, Craig A Umscheid
BACKGROUND: This review will inform updated National Asthma Education and Prevention Program clinical practice guidelines. OBJECTIVE: To evaluate the effectiveness of allergen reduction interventions on asthma outcomes. METHODS: We systematically searched the gray literature and five bibliographic databases. Eligible studies included systematic reviews, randomized controlled trials, and nonrandomized interventional studies. Risk of bias was assessed using the Cochrane Risk of Bias instrument and the Newcastle-Ottawa scale...
February 13, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29449100/hepatitis-a-vaccination-coverage-among-adolescents-13-17-years-in-the-united-states-2008-2016
#17
Noele P Nelson, David Yankey, James A Singleton, Laurie D Elam-Evans
BACKGROUND: The hepatitis A (HepA) vaccine was recommended by the Advisory Committee on Immunization Practices (ACIP) incrementally from 1996 to 1999. In 2006, HepA vaccine was recommended (1) universally for children aged 12-23 months, (2) for persons who are at increased risk for infection, or (3) for any person wishing to obtain immunity. Catch-up vaccination can be considered. OBJECTIVE: To assess HepA vaccine coverage among adolescents and factors independently associated with vaccination administration in the US...
February 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29447492/physiotherapists-management-of-challenging-situations-in-guiding-people-with-rheumatoid-arthritis-to-health-enhancing-physical-activity
#18
Thomas Nessen, Christina H Opava, Cathrin Martin, Ingrid Demmelmaier
OBJECTIVES: To explore strategies used by physiotherapists (PTs) in guiding people with rheumatoid arthritis to health-enhancing physical activity (HEPA) in a group setting during a 1-year intervention study. METHODS: Exploratory design with qualitative video analysis performed in three steps. Eleven female PTs were video recorded while leading support group sessions aiming at facilitating HEPA (twice-weekly exercise sessions at public gyms and 150 weekly minutes of moderately intense aerobic physical activity)...
February 15, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29422372/promoting-health-enhancing-physical-activity-in-europe-current-state-of-surveillance-policy-development-and-implementation
#19
João Breda, Jelena Jakovljevic, Giulia Rathmes, Romeu Mendes, Olivier Fontaine, Susanne Hollmann, Alfred Rütten, Peter Gelius, Sonja Kahlmeier, Gauden Galea
This study aims to present information on the surveillance, policy developments, and implementation of physical activity policies in the 28 European Union (EU) countries. Data was collected on the implementation of the EU Recommendation on health-enhancing physical activity (HEPA) across sectors. In line with the monitoring framework proposed in the Recommendation, a questionnaire was designed to capture information on 23 physical activity indicators. Of the 27 EU countries that responded to the survey, 22 have implemented actions on more than 10 indicators, four countries have implemented more than 20 indicators, and one country has fully addressed and implemented all of the 23 indicators of the monitoring framework...
February 3, 2018: Health Policy
https://www.readbyqxmd.com/read/29398771/lessons-from-in-home-air-filtration-intervention-trials-to-reduce-urban-ultrafine-particle-number-concentrations
#20
Doug Brugge, Matthew C Simon, Neelakshi Hudda, Marisa Zellmer, Laura Corlin, Stephanie Cleland, Eda Yiqi Lu, Sonja Rivera, Megan Byrne, Mei Chung, John L Durant
Background: Exposure to airborne ultrafine particle (UFP; <100 nm in aerodynamic diameter) is an emerging public health problem. Nevertheless, the benefit of using high efficiency particulate arrestance (HEPA) filtration to reduce UFP concentrations in homes is not yet clear. Methods: We conducted a randomized crossover study of HEPA filtration without a washout period in 23 homes of low-income Puerto Ricans in Boston and Chelsea, MA (USA). Most participants were female, older adults who were overweight or obese...
December 2017: Building and Environment
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