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https://www.readbyqxmd.com/read/28437242/anthropometric-reference-data-for-children-and-adults-united-states-2011-2014
#1
C D Fryar, Q Gu, C L Ogden, K M Flegal
Anthropometry or human body measurements provide important indicators of nutritional status in children and adults (1). In children, measurements reflect general health status, dietary adequacy, and growth and development over time. In adults, body measurements are used to evaluate health and dietary status, disease risk, and body composition. This report presents anthropometric reference data for 2011-2014 for U.S. children and adults.
August 2016: Vital & Health Statistics. Series 3, Analytical and Epidemiological Studies
https://www.readbyqxmd.com/read/28436679/cited2-mutations-in-conserved-regions-contribute-to-conotruncal-heart-defects-in-chinese-children
#2
Bojian Li, Tian Pu, Yang Liu, Yuejuan Xu, Rang Xu
Conotruncal heart defects (CTDs) are severe malformations of outflow tract with heterogeneous morphology. Several missense variants of CITED2 have been identified to cause CTDs in recent researches. In this study, we screened the coding regions of CITED2 in 605 Chinese children with CTDs and found two possible pathogenic mutant sites: p.Q117L and p.T257A, both located in the conserved regions of CITED2. Then, we investigated the biological and functional alterations of them. Western blotting showed low level of protein expression of mutant Q117 and T257A compared with wild-type CITED2...
April 24, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28436599/metformin-as-targeted-treatment-in-fragile-x-syndrome
#3
Angel Belle C Dy, Flora Tassone, Marwa Eldeeb, María J Salcedo-Arellano, Nicole Tartaglia, Randi Hagerman
Individuals with Fragile X Syndrome (FXS) may be affected by several comorbid conditions, both behavioral and medical. Growth findings suggest that they are at an increased risk for obesity and overeating. The Prader-Willi phenotype (PWP) of FXS occurs in less than 10% of patients but it is associated with severe hyperphagia, lack of satiation and morbid obesity. Metformin is a drug used in individuals with high risk for diabetes type 2, obesity or impaired glucose tolerance. It has had a strong safety profile in children and adults with type 2 diabetes and obesity...
April 24, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28436333/epidemiology-of-hepatitis-c-infection-in-pakistan-current-estimate-and-major-risk-factors
#4
Aiman Arshad, Usman Ali Ashfaq
In Pakistan, hepatitis C virus (HCV) is a major healthcare problem, with acute and chronic infections responsible for liver damage, cirrhosis, and hepatocellular carcinoma. Under the Human Development Index of the United Nations, Pakistan is ranked 134th of 174 countries due to its poor educational and health standards. This study was designed to study HCV and its genotype prevalence in different cities and provinces of Pakistan and describe the major routes of HCV transmission. Literature searches were performed in PubMed, Mendeley, and Google Scholar...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/28435518/sparc-overexpression-alters-microrna-expression-profiles-involved-in-tumor-progression
#5
Bhavesh K Ahir, Nasya M Elias, Sajani S Lakka
Medulloblastoma is the most common malignant brain tumor in children. SPARC (secreted protein acidic and rich in cysteine), a multicellular non-structural glycoprotein is known to be involved in multiple processes in various cancers. Previously, we reported that SPARC expression significantly impairs medulloblastoma tumor growth in vitro and in vivo and also alters chemo sensitivity. MicroRNAs are a class of post-transcriptional gene regulators with critical functions in tumor progression. In addition, microRNA (miRNA) expression changes are also involved in chemo-resistance...
January 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28435370/facial-profile-and-maxillary-arch-dimensions-in-unilateral-cleft-lip-and-palate-children-in-the-mixed-dentition-stage
#6
Vellore Kannan Gopinath, Ab Rani Samsudin, Siti Noor Fazliah Mohd Noor, Hady Youssef Mohamed Sharab
OBJECTIVES: The aim of this study was to evaluate the vertical and sagittal facial profile and maxillary arch width, depth, and length of patients with unilateral cleft lip and palate (UCLP) and to compare them with healthy noncleft children in the mixed dentition stage (7-13 years). MATERIALS AND METHODS: This study is conducted at Hospital Universiti Sains Malaysia. UCLP group comprised 48 patients with nonsyndromic UCLP who have had the lip and palate repaired, whereas the control group comprised 48 healthy noncleft cases...
January 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28434894/-a-real-world-study-focused-on-the-effectiveness-and-safety-of-adalimumab-as-first-line-anti-tnf-treatment-for-pediatric-crohn-s-disease
#7
Víctor Manuel Navas-López, Gemma Pujol Muncunill, Enrique Llerena, María Navalón Rubio, David Gil-Ortega, Vicente Varea-Calderón, Carlos Sierra Salinas, Javier Martin-de-Carpi
BACKGROUND AND OBJECTIVES: Adalimumab (ADA), a monoclonal humanised anti-TNF antibody, is usually prescribed as a second-line treatment in paediatric Crohn's disease (CD) patients who have become unresponsive or developed intolerance to infliximab (IFX). In the case series reported, more than 70% of patients had initially been treated with IFX. Data on short- and long-term effectiveness of ADA in anti-TNF naïve patients is limited. The aim of this study is to describe our experience with ADA as a first-line anti-TNF in paediatric CD patients...
April 20, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28434427/prenatal-fish-oil-supplementation-and-early-childhood-development-in-the-upstate-kids-study
#8
K Vollet, A Ghassabian, R Sundaram, N Chahal, E H Yeung
Fish oil contains omega-3 fatty acids, which play a vital role in fetal growth and development. In utero exposure to omega-3 fatty acids is exclusively dependent on maternal nutrition. Previous studies have suggested that prenatal fish oil supplementation has positive impacts on child neurodevelopment later in life. This study examines the associations between fish oil supplementation both before pregnancy and throughout pregnancy and subsequent child development. Mother-child pairs from the Upstate KIDS Study, a birth cohort consisting of children born between 2008 and 2010, were included...
April 24, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28433546/symptom-trajectories-in-children-receiving-treatment-for-leukemia-a-latent-class-growth-analysis-with-multitrajectory-modeling
#9
Marilyn J Hockenberry, Mary C Hooke, Cheryl Rodgers, Olga Taylor, Kari M Koerner, Pauline Mitby, Ida Moore, Michael E Scheurer, Wei Pan
CONTEXT: Cancer treatment symptoms play a major role in determining the health of children with cancer. Symptom toxicity often results in complications, treatment delays, and therapy dose reductions that can compromise leukemia therapy and jeopardize chances for long-term survival. Critical to understanding symptom experiences during treatment is the need for exploration of "why" inter-individual symptom differences occur; this will determine who may be most susceptible to treatment toxicities...
April 19, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28433203/the-limitations-of-transforming-very-high-body-mass-indexes-into-z-scores-among-8-7-million-2-to-4-year-old-children
#10
David S Freedman, Nancy F Butte, Elsie M Taveras, Alyson B Goodman, Cynthia L Ogden, Heidi M Blanck
OBJECTIVE: To examine the associations among several body mass index (BMI) metrics (z-scores, percent of the 95th percentile (%BMIp95) and BMI minus 95th percentile (ΔBMIp95) as calculated in the growth charts from the Centers for Disease Control and Prevention (CDC). It is known that the widely used BMI z-scores (BMIz) and percentiles calculated from the growth charts can differ substantially from those that directly observed in the data for BMIs above the 97th percentile (z = 1...
April 19, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28431724/retrosternal-implantation-of-the-cardioverter-defibrillator-lead-in-an-infant
#11
Hiroaki Hata, Naokata Sumitomo, Toshiko Nakai, Atsushi Amano
Using an implantable cardioverter-defibrillator (ICD) in small children is still challenging, but the need is increasing. We present a new approach to overcoming ICD problems caused by growth in infants. A redundant ICD lead was fixed to the superior border of the sternum and tunneled retrosternally to the subxiphoid region for connection to the generator, which was placed in a pocket beneath the left transversus abdominis muscle. The redundant retrosternal part of the lead straightened during growth, while cardiac coverage by the cardioversion energy field and the defibrillation vector were maintained appropriately...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28431557/the-effect-of-vitamin-b12-supplementation-in-nepalese-infants-on-growth-and-development-study-protocol-for-a-randomized-controlled-trial
#12
Tor A Strand, Manjeswori Ulak, Ram K Chandyo, Ingrid Kvestad, Mari Hysing, Merina Shrestha, Sudha Basnet, Suman Ranjitkar, Laxman Shrestha, Prakash S Shrestha
BACKGROUND: Vitamin B12 deficiency is one of the most common micronutrient deficiencies and is associated with poor cognitive development and growth. Vitamin B12 is crucial for normal cell division and differentiation, and it is necessary for the development and myelination of the central nervous system. The aim of the present study is to measure the effect of daily supplementation of vitamin B12 on the neurodevelopment and growth of young children in Nepal. METHODS/DESIGN: We are conducting an individually randomized, double-blind, placebo-controlled trial with 600 marginally stunted children 6-11 months old (length for age less than -1 z-score)...
April 21, 2017: Trials
https://www.readbyqxmd.com/read/28430383/assessment-of-disease-specific-knowledge-in-australian-children-with-inflammatory-bowel-disease-and-their-parents
#13
Andrew S Day, Gaithri Mylvaganam, Nollaig Shalloo, Cathy Clarkson, Steven T Leach, Daniel A Lemberg
AIMS: Disease-specific knowledge may influence disease outcome and quality of life in children with inflammatory bowel disease (IBD). This prospective study aimed to define IBD-related knowledge in a group of Australian children with IBD and their parents using a validated measure of disease-specific knowledge, the Inflammatory Bowel Disease Knowledge Inventory Device (IBD-KID). METHODS: Children (less than 18 years) diagnosed with IBD who were members of the Australian patient support organisation were identified...
April 21, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28429911/inequality-in-malnutrition-by-maternal-education-levels-in-early-childhood-the-prospective-cohort-of-thai-children-pctc
#14
Seo Ah Hong, Pattanee Winichagoon, Aroonsri Mongkolchati
BACKGROUND AND OBJECTIVES: As tackling socioeconomic inequality in child malnutrition still remains one of the greatest challenges in developing countries, we examined maternal educational differences in malnutrition and the magnitude of its inequality among 4,198 children from the Prospective Cohort study of Thai Children (PCTC). METHODS AND STUDY DESIGN: Prevalence of stunting, underweight, and wasting from birth to 24 months was calculated using the new WHO growth chart...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429877/normal-weight-obesity-and-cardiometabolic-risk-a-7-year-longitudinal-study-in-girls-from-prepuberty-to-early-adulthood
#15
Petri Wiklund, Timo Törmäkangas, Yi Shi, Na Wu, Aki Vainionpää, Markku Alen, Sulin Cheng
OBJECTIVE: To study whether normal-weight obesity in childhood is associated with increased cardiometabolic risk in early adulthood. METHODS: This study assessed data for 236 girls followed from prepuberty to early adulthood. Growth chart data were obtained from birth to 18 years. Body composition was assessed by dual-energy x-ray absorptiometry and cardiometabolic risk by calculating continuous clustered risk score (at ages 11, 14, and 18). The association of body weight status with cardiometabolic risk from childhood to early adulthood was examined...
April 21, 2017: Obesity
https://www.readbyqxmd.com/read/28429816/a-randomised-controlled-trial-to-test-the-effect-of-promoting-caregiver-contingent-talk-on-language-development-in-infants-from-diverse-socioeconomic-status-backgrounds
#16
Michelle McGillion, Julian M Pine, Jane S Herbert, Danielle Matthews
BACKGROUND: Early language skills are critical for later academic success. Lower socioeconomic status (SES) children tend to start school with limited language skills compared to advantaged peers. We test the hypothesis that this is due in part to differences in caregiver contingent talk during infancy (how often the caregiver talks about what is in the focus of the infant's attention). METHODS: In a randomised controlled trial with high and low SES families, 142 11-month olds and their caregivers were randomly allocated to either a contingent talk intervention or a dental health control...
April 21, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28427039/low-dose-growth-hormone-treatment-in-infants-and-toddlers-with-prader-willi-syndrome-is-comparable-to-higher-dosage-regimens
#17
Elly Scheermeyer, Mark Harris, Ian Hughes, Patricia A Crock, Geoffrey Ambler, Charles F Verge, Phil Bergman, George Werther, Maria E Craig, Catherine S Choong, Peter S W Davies
OBJECTIVE: Evaluate benefit and risk of low dose growth hormone treatment (GHT, 4.5mg/m(2)/week) in very young children with Prader-Willi Syndrome (PWS). DESIGN: Prospective longitudinal clinical intervention. METHODS: We evaluated 31 infants (aged 2-12months) and 42 toddlers (13-24months) from the PWS-OZGROW database for height, weight and BMI using the World Health Organization standard deviation scores (SDSWHO) and PWS specific BMI (SDSPWS), bone age, insulin-like growth factor 1 (IGF-I) levels and adverse events over 3years of GHT...
March 24, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28426889/concurrent-and-longitudinal-predictors-of-reading-for-deaf-and-hearing-children-in-primary-school
#18
Margaret Harris, Emmanouela Terlektsi, Fiona Elizabeth Kyle
Forty-one children with severe-profound prelingual hearing loss were assessed on single word reading, reading comprehension, English vocabulary, phonological awareness and speechreading at three time points, 1 year apart (T1-T3). Their progress was compared with that of a group of hearing children of similar nonverbal IQ, initially reading at the same level. Single word reading improved at each assessment point for the deaf children but there was no growth in reading comprehension from T2 to T3. There were no differences between children with cochlear implants and those with hearing aids on either reading measure but orally educated children had higher scores than children who signed in the classroom...
April 1, 2017: Journal of Deaf Studies and Deaf Education
https://www.readbyqxmd.com/read/28426828/consumption-of-fortified-infant-foods-reduces-dietary-diversity-but-has-a-positive-effect-on-subsequent-growth-in-infants-from-sumedang-district-indonesia
#19
Aly Diana, Simonette R Mallard, Jillian J Haszard, Dwi Monik Purnamasari, Ikrimah Nurulazmi, Pratami D Herliani, Gaga I Nugraha, Rosalind S Gibson, Lisa Houghton
Stunting and underweight among under-five children in Indonesia are common, raising public health concerns. Whether inappropriate complementary feeding (CF) practices compromise optimal growth during late infancy in Indonesia is uncertain. Therefore we characterized and evaluated CF practices in Indonesian infants and investigated their relationship with subsequent growth. We enrolled breastfed infants at 6 months of age (n = 230); and followed them at 9 (n = 202) and 12 months of age (n = 190). We collected socio-demographic and anthropometric data and two-day in-home weighed food records...
2017: PloS One
https://www.readbyqxmd.com/read/28426678/nutrition-education-improves-dietary-diversity-of-children-6-23-months-at-community-level-results-from-a-cluster-randomized-controlled-trial-in-malawi
#20
Judith Kuchenbecker, Anika Reinbott, Beatrice Mtimuni, Michael B Krawinkel, Irmgard Jordan
BACKGROUND: Low dietary quality and quantity and inappropriate feeding practices can cause undernutrition. Poor nutritional status in early childhood is associated with growth faltering. The objective of the study was to assess the potential of community-based nutrition education to improve height-for-age z-scores in children 6-23 months of age. METHODS AND FINDINGS: We carried out a cluster-randomized-controlled trial to assess the effectiveness of nutrition education...
2017: PloS One
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