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https://www.readbyqxmd.com/read/29341372/renal-transplantation-in-children-under-3%C3%A2-years-of-age-experience-from-a-single-center-study
#1
Yann Loiseau, Justine Bacchetta, Amna Klich, Bruno Ranchin, Delphine Demede, Audrey Laurent, Florent Baudin, Florentine Garaix, Pascal Roy, Pierre Cochat
RTx remains challenging in children under 3 years of age. This single-center study reviewed the medical records of children <3 years transplanted since 1987 (N = 32, Group 1). They were matched for donor type and RTx period with children aged 3-13 years (N = 32, Group 2) and 13-18 years (N = 32, Group 3). There were no between-group significant differences regarding distributions of gender, primary renal disease, proportion of dialysis before RTx, and growth (SDS). Compared to Groups 2 and 3, Group 1 had more peritoneal dialyses (P < ...
January 17, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29341221/pediatric-penile-porokeratosis-a-case-report
#2
Omar Bari, Antoanella Calame, Sarah Marietti-Shepherd, Victoria R Barrio
We present what we believe to be the second case of pediatric penile porokeratosis and the youngest case reported. A 6-year-old boy presented with a pruritic, verrucous growth at the urethral meatus that recurred after two meatotomies. The diagnosis of porokeratosis was confirmed by biopsy. Porokeratosis should be added to the differential diagnosis of chronic hyperkeratotic penile lesions in children.
January 16, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29341046/reduced-growth-hormone-secretion-is-associated-with-nonalcoholic-fatty-liver-disease-in-obese-children
#3
Shuang Liang, Zhen Yu, Xiaobo Song, Yu Wang, Meng Li, Jiang Xue
The purpose of the study was to evaluate the relationship between arginine-levodopa-induced growth hormone (GH) secretion and nonalcoholic fatty liver disease (NAFLD) in obese children. This study includes a total of 84 obese and 43 normal weight children. The obese subjects are divided into two groups based on the presence or absence of NAFLD. Clinical examination, anthropometric and laboratory examinations, and liver ultrasonography are assessed for all participants. The obese group had significantly lower peak stimulated GH (p<0...
January 16, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29340801/maternal-depression-trajectories-from-pregnancy-to-3%C3%A2-years-postpartum-are-associated-with-children-s-behavior-and-executive-functions-at-3-and-6%C3%A2-years
#4
Mina Park, Ursula Brain, Ruth E Grunau, Adele Diamond, Tim F Oberlander
The objective of this study was to investigate how patterns of maternal depressive symptoms from mid-pregnancy to 3 years postpartum are associated with children's behavior at age 3 years and executive functions. Maternal depressive symptoms were measured from mid-pregnancy to 3 years postpartum. Growth mixture modeling was used on standardized maternal depression scores (n = 147) to identify trajectories. Children's behavioral problems and mental health symptomatology (internalizing, externalizing, and attention deficit hyperactivity disorder) were obtained at 3 and 6 years...
January 16, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29340575/the-fragile-state-of-the-national-institutes-of-health-pediatric-research-portfolio-1992-2015-doing-more-with-less
#5
Daniel P Gitterman, W Scott Langford, William W Hay
In this article, we examine the status of the National Institutes of Health (NIH) pediatric research portfolio between start of federal fiscal year (FY) 1992 and end of FY 2015. The NIH experienced the greatest mean annual growth rate during the "doubling era" (FY 1998-2003): both the NIH budget (13.5%) and pediatric research portfolios (11.5%) increased annually by double digits. However, in the "postdoubling" era (FY 2004-2009), both the NIH (2.0%) and pediatric (-0.2%) mean annual growth rates decreased dramatically...
January 16, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29339848/habitual-patellar-dislocation-in-children-results-of-surgical-treatment-by-modified-four-in-one-technique
#6
Ravi Mittal, Avtar Singh Balawat, Vikrant Manhas, Amit Roy, Navin Kumar Singh
Background: Habitual patellar dislocation is a rare condition affecting children. The growth plates are open in children and any surgical intervention should take that in to consideration. We are describing a modified four in one technique for habitual patellar dislocation, which is a soft tissue procedure without the use of any implant. Method: In this study we included 6 children (4 females and 2 males) with open growth plates, which were diagnosed with habitual patellar dislocation...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29338760/increased-plasmodium-chabaudi-malaria-mortality-in-mice-with-nutritional-iron-deficiency-can-be-reduced-by-short-term-adjunctive-iron-supplementation
#7
Filip C Castberg, Lasse Maretty, Trine Staalsoe, Casper Hempel, Erik Clasen-Linde, Lars Hviid, Jørgen A L Kurtzhals
BACKGROUND: Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. This has rendered interventions against iron deficiency in malaria-endemic areas controversial. METHODS: The effect of nutritional iron deficiency on the clinical outcome of Plasmodium chabaudi AS infection in A/J mice and the impact of intravenous iron supplementation with ferric carboxymaltose were studied before and after parasite infection...
January 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29338679/therapeutic-role-of-methotrexate-in-pediatric-crohn-s-disease
#8
REVIEW
Zlatko Djurić, Ljiljana Šaranac, Ivana Budić, Voja Pavlović, Jelena Djordjević
The main role of therapy in Crohn's disease is to achieve long-term clinical remission, and to allow for normal growth and development of children. The immunomodulatory drugs used for the maintenance of remission in Crohn's disease include thiopurines (azathioprine and 6-mercaptopurine) and methotrexate. Development of hepatosplenic T-cell lymphoma in some patients with inflammatory bowel disease, treated with thiopurines independently or in combination with anti-tumor necrosis factor agents, resulted in a growing interest in the therapeutic application of methotrexate in children suffering from Crohn's disease...
January 16, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29337630/ethnic-differences-in-craniofacial-and-upper-spine-morphology-in-children-with-skeletal-class-ii-malocclusion
#9
Eunhye Oh, Sug-Joon Ahn, Liselotte Sonnesen
OBJECTIVES: To analyze differences in upper cervical spine and craniofacial morphology, including posterior cranial fossa and growth prediction signs, between Danish and South Korean pre-orthodontic skeletal Class II children and to analyze associations between upper cervical spine morphology and craniofacial characteristics. MATERIALS AND METHODS: One hundred forty-six skeletal Class II children-93 Danes (54 boys and 39 girls, mean age 12.2 years) and 53 Koreans (27 boys and 26 girls, mean age 10...
January 16, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29336941/age-specific-excess-mortality-patterns-and-transmissibility-during-the-1889-1890-influenza-pandemic-in-madrid-spain
#10
Diego Ramiro, Sara Garcia, Yolanda Casado, Laura Cilek, Gerardo Chowell
PURPOSE: Although the 1889-1890 influenza pandemic was one of the most important epidemic events of the 19th century, little is known about the mortality impact of this pandemic based on detailed respiratory mortality data sets. METHODS: We estimated excess mortality rates for the 1889-1890 pandemic in Madrid from high-resolution respiratory and all-cause individual-level mortality data retrieved from the Gazeta de Madrid, the Official Bulletin of the Spanish government...
December 27, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/29336700/effect-of-daily-exposure-to-an-isolated-soy-protein-supplement-on-body-composition-energy-and-macronutrient-intake-bone-formation-markers-and-lipid-profile-in-children-in-colombia
#11
Wilson Mejía, Diana Córdoba, Paola Durán, Yersson Chacón, Diego Rosselli
A soy protein-based supplement may optimize bone health, support physical growth, and stimulate bone formation. This study aimed to assess the effect of a daily soy protein supplement (SPS) on nutritional status, bone formation markers, lipid profile, and daily energy and macronutrient intake in children. One hundred seven participants (62 girls), ages 2 to 9, started the study and were randomly assigned to lunch fruit juice with (n = 57, intervention group) or without (n = 50, control group) addition of 45 g (230 Kcal) of a commercial SPS during 12 months; 84 children (51 girls, 33 boys) completed the study (45 and 39 intervention and control, respectively)...
January 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29335887/sphingadienes-show-therapeutic-efficacy-in-neuroblastoma-in-vitro-and-in-vivo-by-targeting-the-akt-signaling-pathway
#12
Piming Zhao, Ana E Aguilar, Joanna Y Lee, Lucy A Paul, Jung H Suh, Latika Puri, Meng Zhang, Jennifer Beckstead, Andrzej Witkowski, Robert O Ryan, Julie D Saba
Neuroblastoma is a childhood malignancy that accounts for approximately 15% of childhood cancer deaths. Only 20-35% of children with metastatic neuroblastoma survive with standard therapy. Identification of more effective therapies is essential to improving the outcome of children with high-stage disease. Sphingadienes (SD) are growth-inhibitory sphingolipids found in natural sources including soy. They exhibit chemopreventive activity in mouse models of colon cancer, where they mediate cytotoxicity by inhibiting key pro-carcinogenic signaling pathways...
January 16, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29335375/reflections-on-telomere-dynamics-and-ageing-related-diseases-in-humans
#13
REVIEW
Abraham Aviv, Jerry W Shay
Epidemiological studies have principally relied on measurements of telomere length (TL) in leucocytes, which reflects TL in other somatic cells. Leucocyte TL (LTL) displays vast variation across individuals-a phenomenon already observed in newborns. It is highly heritable, longer in females than males and in individuals of African ancestry than European ancestry. LTL is also longer in offspring conceived by older men. The traditional view regards LTL as a passive biomarker of human ageing. However, new evidence suggests that a dynamic interplay between selective evolutionary forces and TL might result in trade-offs for specific health outcomes...
March 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29334626/parenting-predicts-strange-situation-cortisol-reactivity-among-children-adopted-internationally
#14
Carrie E DePasquale, K Lee Raby, Julie Hoye, Mary Dozier
The functioning of the hypothalamic pituitary adrenal (HPA) axis can be altered by adverse early experiences. Recent studies indicate that children who were adopted internationally after experiencing early institutional rearing and unstable caregiving exhibit blunted HPA reactivity to stressful situations. The present study examined whether caregiving experiences post-adoption further modulate children's HPA responses to stress. Parental sensitivity during naturalistic parent-child play interactions was assessed for 66 children (M age = 17...
January 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29334565/reversal-of-intestinal-failure-in-children-with-tufting-enteropathy-supported-with-parenteral-nutrition-at-home
#15
Iona Ashworth, Alexander Wilson, Samuel Aquilina, Raymond Parascandalo, Victor Mercieca, Jurgen Gerada, Sarah Macdonald, Venetia Simchowitz, Susan Hill
OBJECTIVES: To review long-term outcome of Intestinal Epithelial Dysplasia(IED)/tufting enteropathy(TE) patients treated with parenteral nutrition(PN) at home managed by an intestinal failure(IF) rehabilitation service METHODS:: Infants presenting from 1986-2010 with IF, and TE histology were retrospectively reviewed for up to 30 years. Data collected included: outcome, presentation, nutrition(parenteral/enteral), country of residence, race, EpCAM gene, growth, bone age, occupation. RESULTS: 13 patients (6 male) in Malta and the UK with TE histology were established on home PN...
January 13, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29332860/impact-of-the-great-east-japan-earthquake-on-body-mass-index-weight-and-height-of-infants-and-toddlers-an-infant-survey
#16
Hiroshi Yokomichi, Hiroko Matsubara, Mami Ishikuro, Masahiro Kikuya, Tsuyoshi Isojima, Susumu Yokoya, Noriko Kato, Toshiaki Tanaka, Shoichi Chida, Atsushi Ono, Mitsuaki Hosoya, Soichiro Tanaka, Shinichi Kuriyama, Shigeo Kure, Zentaro Yamagata
BACKGROUND: The body mass index (BMI) of preschool children from 4 years of age through primary school has increased since the Great East Japan Earthquake, but that of children aged under 3 years has not been studied. This study evaluated how the anthropometrics of younger children changed following the earthquake. METHODS: Height and weight data of children living in northeast Japan were collected from 3-, 6-, 18-, and 42-month child health examinations. We compared the changes in BMI, weight, and height among infants affected by the earthquake between their 3- and 6-month health examinations, toddlers affected at 21-30 months of age (affected groups), and children who experienced the earthquake after their 42-month child health examination (unaffected group)...
January 13, 2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/29332108/impact-of-body-mass-index-on-high-blood-pressure-among-obese-children-in-the-western-region-of-saudi-arabia
#17
Abdulmoein E Al-Agha, Areej O Mahjoub
To evaluate the impact of body mass index (BMI) on high blood pressure among obese children and adolescents in western region, Saudi Arabia.  Methods: Cross-sectional data were obtained from 306 (female: 140, male: 166) child, between August 2016 and March 2017. A questioner was filled by health professionals at ambulatory pediatric clinic followed by waist-hip circumference, height, weight, and blood pressure measurement. Diastolic blood pressure (DBP) and systolic blood pressure (SBP) were adjusted to gender, height, and age...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29330920/macronutrient-and-fibre-intake-of-young-spanish-children-with-reference-to-their-in-utero-growth-status-are-they-eating-a-healthy-diet
#18
Rozina Nuruddin, Mireia Urpi-Sarda, Merida Rodriguez-Lopez, Dolores Garcia-Arenas, Eduard Gratacos, Fatima Crispi, Ruthy Acosta-Rojas
AIM: To compare macronutrient and fibre intake by pre-school children born with intra-uterine growth restriction (IUGR) or as appropriate for gestational age (AGA) and to compare their intake with paediatric nutritional recommendations for identification of potential areas of modification during early life. METHODS: A parental 3-day dietary record was obtained for children of age 1-6 years, born at Hospital Clinic, Barcelona, Spain (2002-2007) with IUGR (n = 37) or AGA (n = 53)...
January 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29330051/anti-tumor-effects-of-triptolide-on-angiogenesis-and-cell-apoptosis-in-osteosarcoma-cells-by-inducing-autophagy-via-repressing-wnt-%C3%AE-catenin-signaling
#19
Xugui Li, Qilin Lu, Wei Xie, Yang Wang, Guanqing Wang
Osteosarcoma is a common malignant bone tumor occurring in adolescents and children. The poor prognosis and low 5-year survival rate of osteosarcoma partly due to high metastasis of osteosarcoma. Triptolide (TPL), an extract from Tripterygium wilfordii, is widely used in cancer treatment. In our present study, we aimed to study the effect of TPL in osteosarcoma treatment and explore the associated regulation mechanism. Our study revealed that TPL inhibited angiogenesis by suppressing the expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in dose dependent manner...
January 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29329511/classifying-and-characterizing-the-development-of-adaptive-behavior-in-a-naturalistic-longitudinal-study-of-young-children-with-autism
#20
Cristan Farmer, Lauren Swineford, Susan E Swedo, Audrey Thurm
BACKGROUND: Adaptive behavior, or the ability to function independently in ones' environment, is a key phenotypic construct in autism spectrum disorder (ASD). Few studies of the development of adaptive behavior during preschool to school-age are available, though existing data demonstrate that the degree of ability and impairment associated with ASD, and how it manifests over time, is heterogeneous. Growth mixture models are a statistical technique that can help parse this heterogeneity in trajectories...
January 5, 2018: Journal of Neurodevelopmental Disorders
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