keyword
https://read.qxmd.com/read/38237144/sexual-function-in-women-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Hester Pastoor, Aya Mousa, Hanneke Bolt, Wichor Bramer, Tania S Burgert, Anuja Dokras, Chau Thien Tay, Helena J Teede, Joop Laven
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common and distressing endocrine disorder associated with lower quality of life, subfertility, diabetes, cardiovascular disease, depression, anxiety, and eating disorders. PCOS characteristics, its comorbidities, and its treatment can potentially influence sexual function. However, studies on sexual function in women with PCOS are limited and contradictory. OBJECTIVE AND RATIONALE: The aim was to perform a systematic review of the published literature on sexual function in women with PCOS and assess the quality of the research and certainty of outcomes, to inform the 2023 International Guidelines for the Assessment and Management of PCOS...
January 17, 2024: Human Reproduction Update
https://read.qxmd.com/read/38032057/progestogens-for-prevention-of-luteinising-hormone-lh-surge-in-women-undergoing-controlled-ovarian-hyperstimulation-as-part-of-an-assisted-reproductive-technology-art-cycle
#2
REVIEW
Demián Glujovsky, Romina Pesce, Mariana Miguens, Carlos Sueldo, Agustín Ciapponi
BACKGROUND: Currently, gonadotrophin releasing hormone (GnRH) analogues are used to prevent premature ovulation in ART cycles. However, their costs remain high, the route of administration is invasive and has some adverse effects. Oral progestogens could be cheaper and effective to prevent a premature LH surge. OBJECTIVES: To evaluate the effectiveness and safety of using progestogens to avoid spontaneous ovulation in women undergoing controlled ovarian hyperstimulation (COH)...
November 30, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37753821/in-vitro-fertilisation-for-unexplained-subfertility
#3
REVIEW
Sesh Kamal Sunkara, Mohan S Kamath, Zabeena Pandian, Ahmed Gibreel, Siladitya Bhattacharya
BACKGROUND: In vitro fertilisation (IVF) is a treatment for unexplained subfertility but is invasive, expensive, and associated with risks. OBJECTIVES: To evaluate the effectiveness and safety of IVF versus expectant management, unstimulated intrauterine insemination (IUI), and IUI with ovarian stimulation using gonadotropins, clomiphene citrate (CC), or letrozole in improving pregnancy outcomes. SEARCH METHODS: We searched following databases from inception to November 2021, with no language restriction: Cochrane Gynaecology and Fertility Register, CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL...
September 27, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37638130/the-role-of-iron-in-the-pathogenesis-of-endometriosis-a-systematic-review
#4
JOURNAL ARTICLE
James Wyatt, Sean M Fernando, Simon George Powell, Christopher J Hill, Ilyas Arshad, Chris Probert, Shakil Ahmed, Dharani K Hapangama
STUDY QUESTION: What is the role of iron in the pathophysiology of endometriosis? SUMMARY ANSWER: Iron excess is demonstrated wherever endometriotic tissues are found and is associated with oxidative stress, an inflammatory micro-environment, and cell damage; the iron-mediated oxidative stress is independently linked to subfertility, symptom severity, and malignant transformation. WHAT IS KNOWN ALREADY: Iron is found in excess in endometriotic tissues, and multiple mechanisms have been studied and posited to explain this...
2023: Human Reproduction Open
https://read.qxmd.com/read/37581383/intracytoplasmic-sperm-injection-versus-conventional-in-vitro-fertilisation-in-couples-with-males-presenting-with-normal-total-sperm-count-and-motility
#5
REVIEW
Elizabeth Cutting, Fabrizzio Horta, Vinh Dang, Minouche Me van Rumste, Ben Willem J Mol
BACKGROUND: Starting over 40 years ago, in vitro fertilisation (IVF) has become the cornerstone for fertility treatment. Since then, in 1992, Palermo and colleagues successfully applied the technique intracytoplasmic sperm injection (ICSI) to benefit couples where conventional in vitro fertilisation (c-IVF) and sub-zonal insemination (SUZI) proved unsuccessful. After this case report, ICSI has become the treatment of choice for couples with severe male factor subfertility. Over time, ICSI has been used in the treatment of couples with mild male and even unexplained infertility...
August 15, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/37495550/effect-of-antioxidants-on-semen-parameters-in-men-with-oligo-astheno-teratozoospermia-a-network-meta-analysis
#6
JOURNAL ARTICLE
Arcangelo Barbonetti, Daniele Tienforti, Chiara Castellini, Francesca Di Giulio, Mario Muselli, Alessandro Pizzocaro, Walter Vena, Marco Giorgio Baroni, Rosario Pivonello, Andrea M Isidori, Mario Maggi, Giovanni Corona
BACKGROUND: Although antioxidants are largely used in subfertile men with oligo-astheno-teratozoospermia (OAT), the choice among different molecules is challenged by the lack of comparative head-to-head studies. The network meta-analysis (NMA) can overcome limitations of pairwise meta-analyses, since it incorporates direct and indirect evidence into a single model generating an effectiveness hierarchy. OBJECTIVE: To assess with a NMA the effects of antioxidants in improving seminal parameters in idiopathic OAT...
July 26, 2023: Andrology
https://read.qxmd.com/read/37280035/efficacy-of-coenzyme-q10-supplementation-for-male-infertility-with-high-sperm-dna-fragmentation-index-a-protocol-for-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Yu Zhao, Xiaoli Zhao, Guangyin Zhang, Ruihong Ma, Qiang Geng, Bin Ouyang, Tian Xia
INTRODUCTION: Infertility is a focal issue in public health and affects human reproduction and survival. Notably, an increasing number of studies in recent decades have found that sperm DNA integrity plays a critical role in the development of healthy embryos. Among the multiple pathogenic factors of sperm DNA fragmentation, oxidative stress has proven to be predominant. Coenzyme Q10 supplementation, which has been used for the treatment of male infertility, has shown good clinical efficacy due to its oxidation resistance, but its efficacy as measured by the sperm DNA fragmentation index remains controversial...
June 6, 2023: BMJ Open
https://read.qxmd.com/read/37267890/optimizing-intrauterine-insemination-and-spontaneous-conception-in-women-with-unilateral-hydrosalpinx-or-tubal-pathology-a-systematic-review-and-narrative-synthesis
#8
REVIEW
Jia Yun Yip, Abhiram Kanneganti, Nurulhuda Binte Ahmad, Mei Xian Karen Lim, Siong Lin Stephen Chew, Zhongwei Huang
BACKGROUND: Tubal surgery's role in infertile women with unilateral tubal pathology (e.g. hydrosalpinx, tubal occlusion) who desire spontaneous or intrauterine insemination (IUI) conception where in-vitro fertilisation is infeasible remains unclear. OBJECTIVE: To conduct a systematic review on fertility outcomes in women with unilateral tubal pathology desiring to conceive spontaneously or via IUI and to find guidance to support therapeutic tubal procedures to help these women conceive...
July 2023: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/36940948/effectiveness-and-feasibility-of-online-fertility-preservation-decision-aids-for-young-female-patients-with-cancer-a-systematic-review-protocol
#9
JOURNAL ARTICLE
Ning Qin, Ziyu Wan, Yue Kang, Yating Luo, Yinglong Duan, Jianfei Xie, Andy Sk Cheng
INTRODUCTION: Cancer diagnosis and treatment can impair fertility, and younger female patients with cancer have a particularly strong need for fertility preservation. Fertility preservation decision aids are thought to help patients make proactive and informed treatment decisions. This systematic review aims to assess the effectiveness and feasibility of online fertility preservation decision aids for young female patients with cancer. METHODS AND ANALYSIS: PubMed, Web of Science Core Collection, Embase, The Cochrane Central Register of Controlled Trials, PsycINFO and CHINAL, along with three grey literature sources (Google Scholar, ClinicalTrials...
March 20, 2023: BMJ Open
https://read.qxmd.com/read/36882256/effect-of-and-the-association-between-vitamin-d-and-outcomes-of-assisted-reproductive-techniques-among-infertile-men-and-women-protocol-for-an-overview-of-systematic-reviews-and-meta-analysis
#10
JOURNAL ARTICLE
Bahar Morshed-Behbahani, Leila Doryanizadeh, Shadab Shahali, Saeed Shahabi, Ali Montazeri
INTRODUCTION: Vitamin D is associated with many functions of the human reproductive system. Accordingly, it seems that on infertile couples undergoing assisted reproduction technology (ART), treatment outcomes may be affected by the vitamin D. This overview aims to show the effect of vitamin D on infertility treatments outcomes in recent studies by concluding systematic reviews and meta-analyses to achieve a comprehensive result. METHODS AND ANALYSIS: This overview protocol is being reported according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement and was registered in the International Prospective Register of Systematic Reviews...
March 7, 2023: BMJ Open
https://read.qxmd.com/read/36866921/ataluren-and-similar-compounds-specific-therapies-for-premature-termination-codon-class-i-mutations-for-cystic-fibrosis
#11
REVIEW
Aisha A Aslam, Ian P Sinha, Kevin W Southern
BACKGROUND: Cystic fibrosis (CF) is a common, life-shortening, genetic disorder in populations of Northern European descent caused by the mutation of a single gene that codes for the production of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This protein coordinates the transport of salt (and bicarbonate) across cell surfaces, and the mutation most notably affects the airways. In the lungs of people with CF, the defective protein compromises mucociliary clearance and makes the airway prone to chronic infection and inflammation, damaging the structure of the airways and eventually leading to respiratory failure...
March 3, 2023: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/36721921/the-impact-of-primary-ciliary-dyskinesia-on-female-and-male-fertility-a-narrative-review
#12
JOURNAL ARTICLE
Lydia Newman, Jagrati Chopra, Claire Dossett, Elizabeth Shepherd, Amelia Bercusson, Mary Carroll, Woolf Walker, Jane S Lucas, Ying Cheong
BACKGROUND: Primary ciliary dyskinesia (PCD) is a genetic condition affecting the structure and function of sperm flagellum and motile cilia including those in the male and female reproductive tracts. Infertility is a commonly reported feature of PCD, but there is uncertainty as to how best to counsel patients on their fertility prognosis. OBJECTIVE AND RATIONALE: This review aimed to summarize the prevalence of subfertility, possible underlying mechanisms, and the success of ART in men and women with PCD...
January 31, 2023: Human Reproduction Update
https://read.qxmd.com/read/36680549/clomiphene-citrate-for-male-infertility-a-systematic-review-and-meta-analysis
#13
REVIEW
Manou Huijben, Roel L N Huijsmans, M Tycho W T Lock, Vincent F de Kemp, Laetitia M O de Kort, Jetske H M K van Breda
BACKGROUND: Male infertility is a prevalent and worldwide problem with various difficulties in treatment. Clomiphene citrate is a selective estrogen receptor modulator and may improve semen quality by stimulating hormone synthesis and spermatogenesis. There is lack of evidence on the efficacy of clomiphene citrate as therapy for male infertility. OBJECTIVES: Therefore, a systematic review and meta-analysis was performed to assess the efficacy of clomiphene citrate on sperm quality in infertile men...
January 21, 2023: Andrology
https://read.qxmd.com/read/36642704/ovarian-absence-a-systematic-literature-review-and-case-series-report
#14
REVIEW
H Alexander Chen, Alyssa A Grimshaw, Melissa Taylor-Giorlando, Pavithra Vijayakumar, Dan Li, Miranda Margetts, Emanuele Pelosi, Alla Vash-Margita
Ovarian absence is an uncommon condition that most frequently presents unilaterally. Several etiologies for the condition have been proposed, including torsion, vascular accident, and embryological defect. A systematic review was conducted to describe the clinical presentation of ovarian absence, as well as its associations with other congenital anomalies, through a systematic search of Cochrane Library, ClinicalTrials.gov, Google Scholar, Ovid Embase, Ovid Medline, PubMed, Scopus, and Web of Science. Exclusion criteria included cases with suspicion for Differences of Sex Development, lack of surgically-confirmed ovarian absence, and karyotypes other than 46XX...
January 16, 2023: Journal of Ovarian Research
https://read.qxmd.com/read/36471218/growth-hormone-administration-to-improve-reproductive-outcomes-in-women-with-recurrent-implantation-failure-rif-a-systematic-review
#15
REVIEW
Maira Vera-Montoya, Jose Andrés Calvache, Selmo Geber
Recurrent implantation failure (RIF) has been used to describe embryos' failure to implant following IVF, arising concerns about the importance of its treatment. Growth hormone (GH) has been studied as one of the possible co-interventions. Our updated review evaluated GH intervention vs. no intervention from randomized controlled trials (RCTs) in RIF patients. Electronic searches on The Menstrual Disorders and Subfertility Group (MDSG), The Cochrane Central Register for Clinical Trials, PubMed MEDLINE, EMBASE, PsycINFO, CINAHL, LILACS, and Google Scholar up to August 2021 identified 2 RCTs and compiled with the above inclusion criteria...
December 5, 2022: Reproductive Sciences
https://read.qxmd.com/read/36408057/effects-of-physical-activity-and-sleep-duration-on-fertility-a-systematic-review-and-meta-analysis-based-on-prospective-cohort-studies
#16
Fanqi Zhao, Xiang Hong, Wei Wang, Jingying Wu, Bei Wang
OBJECTIVE: Subfertility is a common problem for couples in modern society. Many studies have confirmed that lifestyle factors can affect fertility although there are conflicting conclusions relating to the effects of physical activity and sleep duration on fertility. In this study, we aimed to summarize and analyze the available evidence. METHODS: PubMed, Web of Science, Cochrane, and Embase databases (as of October 14, 2022) were systematically searched for eligible prospective cohort studies...
2022: Frontiers in Public Health
https://read.qxmd.com/read/36344004/dietary-and-or-physical-activity-interventions-in-women-with-overweight-or-obesity-prior-to-fertility-treatment-protocol-for-a-systematic-review-and-individual-participant-data-meta-analysis
#17
JOURNAL ARTICLE
Emily Evans-Hoeker, Zheng Wang, Henk Groen, Astrid E P Cantineau, Ann Thurin-Kjellberg, Christina Bergh, Joop S E Laven, Alexandra Dietz de Loos, Geranne Jiskoot, Jean-Patrice Baillargeon, Stefano Palomba, Kyra Sim, Lisa J Moran, Juan J Espinós, Trine Moholdt, Amy E Rothberg, Donna Shoupe, Annemieke Hoek, Richard S Legro, Ben W Mol, Rui Wang
INTRODUCTION: Dietary and/or physical activity interventions are often recommended for women with overweight or obesity as the first step prior to fertility treatment. However, randomised controlled trials (RCTs) so far have shown inconsistent results. Therefore, we propose this individual participant data meta-analysis (IPDMA) to evaluate the effectiveness and safety of dietary and/or physical activity interventions in women with infertility and overweight or obesity on reproductive, maternal and perinatal outcomes and to explore if there are subgroup(s) of women who benefit from each specific intervention or their combination (treatment-covariate interactions)...
November 7, 2022: BMJ Open
https://read.qxmd.com/read/35993457/herbal-medicines-for-idiopathic-male-infertility-a-systematic-review
#18
JOURNAL ARTICLE
Mohammad Ahmadian, Roshanak Salari, Mohammad Reza Noras, HamidReza Bahrami-Taghanaki
BACKGROUND: Various medications, surgeries, and assisted reproductive techniques are used to treat male infertility, but the high cost and low effectiveness have made these methods unpopular. the use of herbal medicines such as Withania somnifera, Ceratonia siliqua, Nigella sativa and Alpinia officinarum for the treatment of male infertility has become highly popular in recent years. OBJECTIVE: We conducted this systematic review to evaluate the recent scientific evidence regarding herbal medicines used to treat idiopathic male infertility [IMI]...
August 20, 2022: Current Drug Discovery Technologies
https://read.qxmd.com/read/35809282/efficacy-of-combined-antioxidant-therapy-in-male-subfertility-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Samuel Kofi Arhin, Stephen Ocansey, Precious Barnes, Collins Paa Kwesi Botchey, Hannah Benedicta Taylor-Adbulai
Antioxidant therapy is a potentially promising approach to improve clinical outcomes for couples undergoing assisted reproduction techniques long-term. The review aims to (a) collate evidence for the effectiveness of combined oral antioxidant supplementation, including a head-to-head comparison in the treatment of male subfertility, and (b) investigate whether other intervention features, including duration, specific combinations, or dosage affect clinical outcomes in this population. Randomized controlled trials (RCTs) that examined the effectiveness of combined antioxidants on male subfertility, electronic databases including PubMed, Embase, CINAHL, PSYCHINFO, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched...
January 2, 2022: Cellular and Molecular Biology
https://read.qxmd.com/read/35771604/peri-implantation-glucocorticoid-administration-for-assisted-reproductive-technology-cycles
#20
REVIEW
Carolien M Boomsma, Mohan S Kamath, Stephen D Keay, Nick S Macklon
BACKGROUND: The use of peri-implantation glucocorticoids has been advocated to improve embryo implantation during assistive reproductive technology (ART) cycles such as in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI). It has been proposed that glucocorticoids may improve the intrauterine environment by acting as immunomodulators to reduce the uterine natural killer (NK) cell count and activity, normalising the cytokine expression profile in the endometrium and by suppression of endometrial inflammation...
June 30, 2022: Cochrane Database of Systematic Reviews
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