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https://www.readbyqxmd.com/read/29121766/percutaneous-coronary-intervention-reduces-mortality-in-myocardial-infarction-patients-with-comorbidities-implications-for-elderly-patients-with-diabetes-or-kidney-disease
#1
Irene R Dégano, Isaac Subirana, Danilo Fusco, Luigi Tavazzi, Inge Kirchberger, Dimitrios Farmakis, Jean Ferrières, Ana Azevedo, Marina Torre, Pascal Garel, Max Brosa, Marina Davoli, Christa Meisinger, Vanina Bongard, Carla Araújo, John Lekakis, Albert Francès, Conxa Castell, Roberto Elosua, Jaume Marrugat
BACKGROUND: Percutaneous coronary intervention (PCI) reduces mortality in most myocardial infarction (MI) patients but the effect on elderly patients with comorbidities is unclear. Our aim was to analyse the effect of PCI on in-hospital mortality of MI patients, by age, sex, ST elevation on presentation, diabetes mellitus (DM) and chronic kidney disease (CKD). METHODS: Cohort study of 79,791 MI patients admitted at European hospitals during 2000-2014. The effect of PCI on in-hospital mortality was analysed by age group (18-74, ≥75years), sex, presence of ST elevation, DM and CKD, using propensity score matching...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29092921/contrast-induced-acute-kidney-injury-and-mortality-in-st-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#2
Johanne Silvain, Lee S Nguyen, Vincent Spagnoli, Mathieu Kerneis, Paul Guedeney, Nicolas Vignolles, Kristel Cosker, Olivier Barthelemy, Claude Le Feuvre, Gérard Helft, Jean-Philippe Collet, Gilles Montalescot
OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is a common and potentially severe complication in patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). There is no consensus on the best definition of CI-AKI to identify patients at risk of haemodialysis or death. The objective of this study was to assess the association of CI-AKI, using four definitions, on inhospital mortality, mortality or haemodialysis requirement over 1-year follow-up, in patients with STEMI treated with pPCI...
November 1, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28966444/percutaneous-coronary-intervention-and-inpatient-mortality-in-patients-with-advanced-chronic-kidney-disease-presenting-with-acute-coronary-syndrome
#3
Brijesh Patel, Mahek Shah, Raman Dusaj, Sharon Maynard, Nainesh Patel
Chronic kidney disease (CKD) is an important risk factor for coronary artery disease, yet patients with CKD are less likely to undergo coronary angiography and percutaneous coronary intervention (PCI). We retrospectively analyzed the 2006-2012 National Inpatient Sample Database to examine the temporal trends in coronary angiography and PCI among patients without CKD, with advanced CKD (CKD III-V), and with end-stage renal disease (ESRD) presenting with unstable angina/non-ST elevation myocardial infarction (NSTE-ACS) and ST-elevation myocardial infarction (STEMI)...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28948753/impact-of-chronic-kidney-disease-on-mortality-in-patients-with-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention-a-long-term-single-centre-mortality-study
#4
Mattia Peyracchia, Paolo Scacciatella, Federico Conrotto, Ilaria Meynet, Lorenza M Biava, Carlo Budano, Mauro Pennone, Maurizio D'Amico, Fiorenzo Gaita
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of mortality. We examined the impact of moderate and severe CKD at presentation on short- and long-term mortality among unselected patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI). METHODS: The study cohort consists of 501 patients (pts), enrolled from October 2005 to December 2012. The median follow-up was 46...
September 25, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28749948/anemia-a-significant-cardiovascular-mortality-risk-after-st-segment-elevation-myocardial-infarction-complicated-by-the-comorbidities-of-hypertension-and-kidney-disease
#5
Wei-Chieh Lee, Hsiu-Yu Fang, Huang-Chung Chen, Chien-Jen Chen, Cheng-Hsu Yang, Chi-Ling Hang, Chiung-Jen Wu, Chih-Yuan Fang
BACKGROUND: The effect of anemia on patients with ST-segment elevation myocardial infarction (STEMI) remains a controversial issue. The aim of this study was to explore the effect of anemia on STEMI patients. METHODS AND RESULTS: From January 2005 to December 2014, 1751 patients experienced STEMI checked serum hemoglobin initially before any administration of fluids or IV medications. 1751 patients then received primary percutaneous intervention immediately. A total of 1388 patients were enrolled in the non-anemia group because their serum hemoglobin level was more than 13 g/L in males, and 12 g/L in females...
2017: PloS One
https://www.readbyqxmd.com/read/28611788/prognostic-implications-of-chronic-kidney-disease-on-patients-presenting-with-st-segment-elevation-myocardial-infarction-with-versus-without-stent-thrombosis
#6
Gilad Margolis, Shahar Vig, Nir Flint, Shafik Khoury, Michael Barkagan, Gad Keren, Yacov Shacham
BACKGROUND: Limited data is present regarding long-term outcomes in chronic kidney disease (CKD) patients presenting with stent thrombosis (ST). We evaluated the possible implications of CKD on long-term mortality in patients presenting with ST-segment elevation myocardial infarction (STEMI) and treated with primary percutaneous coronary intervention (PCI), and its interaction with the presence of ST. METHODS: We retrospectively studied 1,722 STEMI patients treated with primary PCI...
February 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/28454811/compliance-with-guideline-directed-therapy-in-diabetic-patients-admitted-with-acute-coronary-syndrome-findings-from-the-american-heart-association-s-get-with-the-guidelines-coronary-artery-disease-gwtg-cad-program
#7
Prakash Deedwania, Tushar Acharya, Kamal Kotak, Gregg C Fonarow, Christopher P Cannon, Warren K Laskey, W Frank Peacock, Wenqin Pan, Deepak L Bhatt
BACKGROUND: To evaluate and compare baseline characteristics, outcomes and compliance with guideline based therapy at discharge among diabetic and non-diabetic patients admitted with acute coronary syndromes (ACS). METHODS AND RESULTS: Study population consisted of 151,270 patients admitted with ACS from 2002 through 2008 at 411 sites participating in the American Heart Association's Get with the Guidelines (GWTG) program. Demographic variables, physical exam findings, laboratory data, left ventricular ejection fraction, length of stay, in-hospital mortality and discharge medications were compared between diabetic and non-diabetic patients...
May 2017: American Heart Journal
https://www.readbyqxmd.com/read/28400120/impact-of-point-of-care-pre-procedure-creatinine-and-egfr-testing-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-primary-pci-the-pilot-statcreat-study
#8
Grigoris V Karamasis, James Hampton-Till, Firas Al-Janabi, Shah Mohdnazri, Michael Parker, Adam Ioannou, Rohan Jagathesan, Alagmir Kabir, Jeremy W Sayer, Nicholas M Robinson, Rajesh K Aggarwal, Gerald J Clesham, Reto A Gamma, Paul A Kelly, Kare H Tang, John R Davies, Thomas Keeble
BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is a recognised complication during primary PCI that affects short and long term prognosis. The aim of this study was to assess the impact of point-of-care (POC) pre-PPCI creatinine and eGFR testing in STEMI patients. METHODS: 160 STEMI patients (STATCREAT group) with pre-procedure POC testing of Cr and eGFR were compared with 294 consecutive retrospective STEMI patients (control group). Patients were further divided into subjects with or without pre-existing CKD...
August 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28150284/renal-function-on-admission-affects-both-treatment-strategy-and-long-term-outcomes-of-patients-with-myocardial-infarction-from-polish-registry-of-acute-coronary-syndromes
#9
MIchal Hawranek, Marek Gierlotka, Mariusz Gąsior, Bartosz Hudzik, Piotr Desperak, Aneta Ciślak, Mateusz Tajstra, Tadeusz Osadnik, Piotr Rozentryt, Lech Poloński
BACKGROUND: Impairment of renal function (IRF) is an independent risk factor of myocardial infarction (MI). AIM: The aims of study was to determine if the presence of IRF affects the choice of treatment strategy in patients with MI, and if long-term mortality rates are influenced by the use of invasive strategy in patients with MI according to the grade of IRF. METHODS: Data from the PL-ACS Registry of 22,431 patients hospitalized for MI during 2007-2008 with an available estimated glomerular filtration rate (eGFR) with 2009 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula were included...
February 2, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28145489/improving-the-diagnostic-accuracy-of-acute-myocardial-infarction-with-the-use-of-high-sensitive-cardiac-troponin-t-in-different-chronic-kidney-disease-stages
#10
Hongliu Yang, Jing Liu, Han Luo, Xiaoxi Zeng, Xi Tang, Liang Ma, Hongxia Mai, Shenju Gou, Fang Liu, Ping Fu
High-sensitive cardiac troponin T (hs-TnT) is a critical biomarker in diagnosis of acute myocardial infarction (AMI). However, CKD individuals usually have elevated hs-TnT even in the absence of AMI. Our study aimed to explore the optimal cutoff-value of hs-TnT and further to improve diagnostic accuracy of AMI in CKD patients. Clinical data of 489 patients were collected from the maintained database between September 2010 and June 2014. CKD patients with AMI were assigned to CKD+AMI group and CKD patients without AMI were assigned to CKD group...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097322/management-and-outcomes-of-st-segment-elevation-myocardial-infarction-in-us-renal-transplant-recipients
#11
Tanush Gupta, Dhaval Kolte, Sahil Khera, Kashish Goel, Wilbert S Aronow, Howard A Cooper, Diwakar Jain, Charanjit S Rihal, Gregg C Fonarow, Julio A Panza, Deepak L Bhatt
Importance: Renal transplantation is associated with reduction in the risk for myocardial infarction (MI) in patients with chronic kidney disease requiring long-term dialysis (stage 5D CKD). Whether outcomes of MI differ among renal transplant recipients vs patients with stage 5D CKD or those without CKD has not been well examined. Objectives: To compare in-hospital reperfusion rates and outcomes of ST-segment elevation MI (STEMI) in renal transplant recipients vs the stage 5D CKD group or the non-CKD group...
March 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/27445026/gender-differences-in-the-prognostic-impact-of-chronic-kidney-disease-in-patients-with-left-ventricular-systolic-dysfunction-following-st-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#12
Lidija Savic, Igor Mrdovic, Milika Asanin, Sanja Stankovic, Gordana Krljanac, Ratko Lasica
BACKGROUND/AIM: Renal function potentially has different prognostic impact in men and women with acute myocardial infarction. The aim of this study was to evaluate the prognostic impact of chronic kidney disease (CKD) on five-year all-cause mortality in men and women with left ventricular systolic dysfunction (LVSD) following ST elevation myocardial infarction (STEMI). METHOD: We included 348 consecutive STEMI patients who were treated with primary percutaneous coronary intervention (pPCI) and had a left ventricular ejection fraction < 40%...
March 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27379919/impact-of-chronic-kidney-disease-on-clinical-outcomes-in-patients-with-non-st-elevation-myocardial-infarction-receiving-percutaneous-coronary-intervention-a-five-year-observational-study
#13
Hui-Ting Wang, Yung-Lung Chen, Chiung-Jen Wu
BACKGROUND: Patients with chronic kidney disease (CKD) experience poor outcomes after acute myocardial infarction. This study investigated how CKD affects clinical outcomes in patients with non-ST segment elevation myocardial infarction (NSTEMI) receiving PCI. METHODS: This retrospective study analyzed record-linked data for 314 patients who had received PCI for NSTEMI between January 2008 and September 2010. The 141 patients with advanced CKD were compared with 173 patients who had mild or no CKD...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27296258/-the-role-of-chronic-kidney-disease-in-assessing-the-risk-of-the-poor-course-of-hospital-st-segment-elevation-myocardial-infarction
#14
V N Karetnikova, V V Kalaeva, M V Evseeva, A V Osokina, V V Kashtalap, O V Gruzdeva, K S Shafranskaya, M V Zykov, O L Barbarash
AIM: To evaluate the prognostic impact of chronic kidney disease (CKD) during hospital stay in patients with ST-segment elevation myocardial infarction (STEMI) and to specify factors showing a negative impact of CKD. SUBJECTS AND METHODS: 954 patients with STEMI were examined. The diagnosis of CKD was verified in 338 (35.4%). In all the patients, glomerular filtration rate (GFR) was calculated using the CKD-EPI formula with regard to serum creatinine levels on admission and before discharge (on days 10--12)...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27070161/-renal-function-estimation-formulas-in-predicting-long-term-cardiovascular-outcomes-in-patients-with-myocardial-infarction-concurrent-with-diabetes-mellitus
#15
V N Karetnikova, A V Osokina, M V Evseeva, V V Kalaeva, O V Gruzdeva, V V Kashtalap, M V Zykov, O E Avramenko, O L Barbarash
AIM: To comparatively assess formulas for estimating glomerular filtration rate (GFR) in the prediction of poor outcomes in patients with type 2 diabetes mellitus (DM) within one year after myocardial infarction (MI). MATERIALS AND METHODS: The investigators examined 89 patients with ST-segment elevation myocardial infarction (STEMI) within 24 hours after the onset of clinical symptoms of the disease. All the patients underwent standard laboratory and instrumental tests...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27056183/determinants-of-growth-differentiation-factor-15-in-patients-with-stable-and-acute-coronary-artery-disease-a-prospective-observational-study
#16
Serdar Farhan, Matthias K Freynhofer, Ivan Brozovic, Veronika Bruno, Birgit Vogel, Ioannis Tentzeris, Sabina Baumgartner-Parzer, Kurt Huber, Alexandra Kautzky-Willer
BACKGROUND: Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor ß family and has been associated with inflammation, cancer, aging, diabetes mellitus (DM) and atherosclerosis. Determinants of GDF-15 have been investigated in several conditions. We aimed to investigate determinants of GDF-15 plasma levels in patients with angiographically proven coronary artery disease (CAD). METHODS: Four hundred and seventy three consecutive patients with CAD were investigated between May 2009 and February 2011...
April 8, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26995007/the-impact-of-stage-of-chronic-kidney-disease-on-the-outcomes-of-diabetics-with-acute-myocardial-infarction-treated-with-percutaneous-coronary-intervention
#17
COMPARATIVE STUDY
Teodora Vichova, Jiri Knot, Jaroslav Ulman, Marek Maly, Zuzana Motovska
BACKGROUND: Patients with diabetes mellitus (DM) or chronic kidney disease (CKD) have a high risk of acute myocardial infarction and recurrent cardiovascular events. According to the previous studies, the combination of the two conditions may have a synergistic impact on prognosis. The aim of this study was to assess the impact of stage of CKD on the outcomes of patients with DM and ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). METHODS: Study population consisted of 946 consecutive patients with STEMI who underwent PCI from January 2009 to December 2012 and were followed up until the end of 2013...
July 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/26980923/serum-galectin-and-renal-dysfunction-in-st-segment-elevation-myocardial-infarction
#18
Victoria Karetnikova, Anastasia Osokina, Olga Gruzdeva, Evgenya Uchasova, Michael Zykov, Victoria Kalaeva, Vasily Kashtalap, Kristina Shafranskaya, Oksana Hryachkova, Olga Barbarash
This study aimed to evaluate the association between serum galectin levels and renal dysfunction in relation to in-hospital prognosis and unfavorable prognosis 1 year after ST-elevated myocardial infarction (STEMI). Patients were assigned to two groups according to the cystatin C-based estimate of GFR on day 12 after STEMI: (1) STEMI patients with normal renal function (GFR based on cystatin C levels = 60 mL/min/1.73 m(2)) and (2) those with renal dysfunction (RD) (GFR based on cystatin C levels <60 mL/min/1...
2016: Disease Markers
https://www.readbyqxmd.com/read/26399570/glomerular-filtration-rate-gfr-during-and-after-stemi-a-single-centre-methodological-study-comparing-estimated-and-measured-gfr
#19
COMPARATIVE STUDY
Dimitrios Venetsanos, Joakim Alfredsson, Mårten Segelmark, Eva Swahn, Sofia Sederholm Lawesson
OBJECTIVES: To validate the performance of the most commonly used formulas for estimation of glomerular filtration rate (GFR) against measured GFR during the index hospitalisation for ST-elevation myocardial infarction (STEMI). SETTING: Single centre, methodological study. PARTICIPANTS: 40 patients with percutaneous coronary intervention-treated STEMI were included between November 2011 and February 2013. Patients on dialysis, cardiogenic shock or known allergy to iodine were excluded...
2015: BMJ Open
https://www.readbyqxmd.com/read/26238770/influence-of-chronic-kidney-disease-on-anticoagulation-levels-and-bleeding-after-primary-percutaneous-coronary-intervention-in-patients-treated-with-unfractionated-heparin
#20
Wouter J Kikkert, Peter M van Brussel, Peter Damman, Bimmer E Claessen, Jan P van Straalen, Marije M Vis, Jan Baan, Karel T Koch, Ron J Peters, Robbert J de Winter, Jan J Piek, Jan G P Tijssen, Jose P S Henriques
Unfractionated heparin (UFH) plasma protein binding and elimination might be impaired in patients with chronic kidney disease (CKD-defined as creatinine clearance <60 ml/min). It is currently unknown at which UFH bolus dose persistent prolongation of activated partial thromboplastin time (aPTT) occurs in ST-segment elevation myocardial infarction (STEMI) patients with CKD. We investigated the effect of different UFH bolus doses on the first aPTT measured within 6 and 12 h after PPCI in 1071 STEMI patients with and without CKD undergoing primary percutaneous coronary intervention (PPCI) between 1-1-2003 and 31-07-2008...
April 2016: Journal of Thrombosis and Thrombolysis
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