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Ckd and stemi

Lidija Savic, Igor Mrdovic, Milika Asanin, Sanja Stankovic, Gordana Krljanac, Ratko Lasica
BACKGROUND/AIM: Renal function potentially has different prognostic impact in men and women with acute myocardial infarction. The aim of this study was to evaluate the prognostic impact of chronic kidney disease (CKD) on five-year all-cause mortality in men and women with left ventricular systolic dysfunction (LVSD) following ST elevation myocardial infarction (STEMI). METHOD: We included 348 consecutive STEMI patients who were treated with primary percutaneous coronary intervention (pPCI) and had a left ventricular ejection fraction < 40%...
March 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Hui-Ting Wang, Yung-Lung Chen, Chiung-Jen Wu
BACKGROUND: Patients with chronic kidney disease (CKD) experience poor outcomes after acute myocardial infarction. This study investigated how CKD affects clinical outcomes in patients with non-ST segment elevation myocardial infarction (NSTEMI) receiving PCI. METHODS: This retrospective study analyzed record-linked data for 314 patients who had received PCI for NSTEMI between January 2008 and September 2010. The 141 patients with advanced CKD were compared with 173 patients who had mild or no CKD...
October 1, 2016: International Journal of Cardiology
V N Karetnikova, V V Kalaeva, M V Evseeva, A V Osokina, V V Kashtalap, O V Gruzdeva, K S Shafranskaya, M V Zykov, O L Barbarash
AIM: To evaluate the prognostic impact of chronic kidney disease (CKD) during hospital stay in patients with ST-segment elevation myocardial infarction (STEMI) and to specify factors showing a negative impact of CKD. SUBJECTS AND METHODS: 954 patients with STEMI were examined. The diagnosis of CKD was verified in 338 (35.4%). In all the patients, glomerular filtration rate (GFR) was calculated using the CKD-EPI formula with regard to serum creatinine levels on admission and before discharge (on days 10--12)...
2016: Terapevticheskiĭ Arkhiv
V N Karetnikova, A V Osokina, M V Evseeva, V V Kalaeva, O V Gruzdeva, V V Kashtalap, M V Zykov, O E Avramenko, O L Barbarash
AIM: To comparatively assess formulas for estimating glomerular filtration rate (GFR) in the prediction of poor outcomes in patients with type 2 diabetes mellitus (DM) within one year after myocardial infarction (MI). MATERIALS AND METHODS: The investigators examined 89 patients with ST-segment elevation myocardial infarction (STEMI) within 24 hours after the onset of clinical symptoms of the disease. All the patients underwent standard laboratory and instrumental tests...
2016: Terapevticheskiĭ Arkhiv
Serdar Farhan, Matthias K Freynhofer, Ivan Brozovic, Veronika Bruno, Birgit Vogel, Ioannis Tentzeris, Sabina Baumgartner-Parzer, Kurt Huber, Alexandra Kautzky-Willer
BACKGROUND: Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor ß family and has been associated with inflammation, cancer, aging, diabetes mellitus (DM) and atherosclerosis. Determinants of GDF-15 have been investigated in several conditions. We aimed to investigate determinants of GDF-15 plasma levels in patients with angiographically proven coronary artery disease (CAD). METHODS: Four hundred and seventy three consecutive patients with CAD were investigated between May 2009 and February 2011...
2016: Cardiovascular Diabetology
Teodora Vichova, Jiri Knot, Jaroslav Ulman, Marek Maly, Zuzana Motovska
BACKGROUND: Patients with diabetes mellitus (DM) or chronic kidney disease (CKD) have a high risk of acute myocardial infarction and recurrent cardiovascular events. According to the previous studies, the combination of the two conditions may have a synergistic impact on prognosis. The aim of this study was to assess the impact of stage of CKD on the outcomes of patients with DM and ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI). METHODS: Study population consisted of 946 consecutive patients with STEMI who underwent PCI from January 2009 to December 2012 and were followed up until the end of 2013...
July 2016: International Urology and Nephrology
Victoria Karetnikova, Anastasia Osokina, Olga Gruzdeva, Evgenya Uchasova, Michael Zykov, Victoria Kalaeva, Vasily Kashtalap, Kristina Shafranskaya, Oksana Hryachkova, Olga Barbarash
This study aimed to evaluate the association between serum galectin levels and renal dysfunction in relation to in-hospital prognosis and unfavorable prognosis 1 year after ST-elevated myocardial infarction (STEMI). Patients were assigned to two groups according to the cystatin C-based estimate of GFR on day 12 after STEMI: (1) STEMI patients with normal renal function (GFR based on cystatin C levels = 60 mL/min/1.73 m(2)) and (2) those with renal dysfunction (RD) (GFR based on cystatin C levels <60 mL/min/1...
2016: Disease Markers
Dimitrios Venetsanos, Joakim Alfredsson, Mårten Segelmark, Eva Swahn, Sofia Sederholm Lawesson
OBJECTIVES: To validate the performance of the most commonly used formulas for estimation of glomerular filtration rate (GFR) against measured GFR during the index hospitalisation for ST-elevation myocardial infarction (STEMI). SETTING: Single centre, methodological study. PARTICIPANTS: 40 patients with percutaneous coronary intervention-treated STEMI were included between November 2011 and February 2013. Patients on dialysis, cardiogenic shock or known allergy to iodine were excluded...
2015: BMJ Open
Wouter J Kikkert, Peter M van Brussel, Peter Damman, Bimmer E Claessen, Jan P van Straalen, Marije M Vis, Jan Baan, Karel T Koch, Ron J Peters, Robbert J de Winter, Jan J Piek, Jan G P Tijssen, Jose P S Henriques
Unfractionated heparin (UFH) plasma protein binding and elimination might be impaired in patients with chronic kidney disease (CKD-defined as creatinine clearance <60 ml/min). It is currently unknown at which UFH bolus dose persistent prolongation of activated partial thromboplastin time (aPTT) occurs in ST-segment elevation myocardial infarction (STEMI) patients with CKD. We investigated the effect of different UFH bolus doses on the first aPTT measured within 6 and 12 h after PPCI in 1071 STEMI patients with and without CKD undergoing primary percutaneous coronary intervention (PPCI) between 1-1-2003 and 31-07-2008...
April 2016: Journal of Thrombosis and Thrombolysis
Sofia Sederholm Lawesson, Joakim Alfredsson, Karolina Szummer, Mats Fredrikson, Eva Swahn
OBJECTIVES: Gender differences in prevalence and prognostic impact of chronic kidney disease (CKD) in ST segment elevation myocardial infarction (STEMI) have been poorly evaluated. In STEMI, female gender has been independently associated with an increased risk of mortality. CKD has been found to be an important prognostic marker in myocardial infarction. The aim of this study was to evaluate gender differences in prevalence and prognostic impact of CKD on short-term and long-term mortality...
2015: BMJ Open
A Gaskina, S Villevalde, Z Kobalava
OBJECTIVE: The incidence of contrast-induced acute kidney injury (CI-AKI) is rising due to increased use of coronary angiography and percutaneous coronary intervention (PCI). Patients undergoing primary PCI are at high risk of CI-AKI, a complication that negatively affects outcomes. The aim of the study was to evaluate the incidence, predictors and outcomes of CI-AKI in patients with ST-segment elevation myocardial infarction (STEMI) and primary PCI. DESIGN AND METHOD: 216 patients with STEMI and primary PCI (143 male, 64 ± 13 years (M ± SD), arterial hypertension 90%, previous myocardial infarction 27%, diabetes mellitus 21%, known chronic kidney disease 7%, anemia 14%, heart failure 62%, left ventricular ejection fraction (LV EF) 44 ± 15%) were examined...
June 2015: Journal of Hypertension
Ashique Ali Khoso, Khawar Abbas Kazmi, Saqiba Tahir, Hasanat Sharif, Safia Awan
BACKGROUND AND OBJECTIVE: Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery are two alternative methods for coronary revascularization, but it remains controversial as which one is associated with lower risks of worse clinical outcomes for chronic kidney disease (CKD) patients. We determined the mode of coronary revascularization (PCI vs. CABG) which is associated with lower risk of mortality and morbidity in CKD patients. METHODS: In this cross sectional study, 159 patients with CKD were enrolled from single center of coronary revascularization at Aga Khan University Hospital Karachi between January 2012 and August 2013...
November 2014: Pakistan Journal of Medical Sciences Quarterly
Thomas T Tsai, Uptal D Patel, Tara I Chang, Kevin F Kennedy, Frederick A Masoudi, Michael E Matheny, Mikhail Kosiborod, Amit P Amin, William S Weintraub, Jeptha P Curtis, John C Messenger, John S Rumsfeld, John A Spertus
BACKGROUND: We developed risk models for predicting acute kidney injury (AKI) and AKI requiring dialysis (AKI‐D) after percutaneous coronary intervention (PCI) to support quality assessment and the use of preventative strategies. METHODS AND RESULTS: AKI was defined as an absolute increase of ≥0.3 mg/dL or a relative increase of 50% in serum creatinine (AKIN Stage 1 or greater) and AKI‐D was a new requirement for dialysis following PCI. Data from 947 012 consecutive PCI patients and 1253 sites participating in the NCDR Cath/PCI registry between 6/09 and 7/11 were used to develop the model, with 70% randomly assigned to a derivation cohort and 30% for validation...
December 2014: Journal of the American Heart Association
L A Ferrara, L Staiano, V Di Fronzo, F Ferrara, A Sforza, C Mancusi, G de Simone
BACKGROUND AND AIM: Association of coronary and renal disease has been frequently found in epidemiological studies. Whether ECG-graphic presentation of myocardial infarction [S-T Elevated MI (STEMI) or Non S-T Elevated MI (NSTEMI)] is related to the degree of renal dysfunction is still unclear. METHODS AND RESULTS: We examined 146 patients with acute myocardial infarction, consecutively entering the Coronary Care Unit of our ward. At entry, patients underwent clinical, ECG-graphic and echocardiographic examination, and blood samples were withdrawn for cardiac markers and general biochemistry...
February 2015: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Marta Negrusz-Kawecka, Rafał Poręba, Anna Hulok, Krzysztof Sciborski, Jakub Marczak, Tomasz Bańkowski
OBJECTIVES: Cystatin C is a novel marker used in the diagnosis of preclinical chronic kidney disease (CKD). The aim of the study was to assess the role of cystatin C in the diagnosis of coronary artery disease. MATERIAL AND METHODS: The study involved 63 patients of a mean age of 62.7 ± 9.5 years. The population was divided into two groups: Group I were patients with angiographically diagnosed coronary artery disease (CAD) with their first acute coronary syndrome (ACS, n = 45); Group II were patients who had clinically diagnosed coronary disease but were negative on angiography (n = 18)...
July 2014: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Hiroaki Watabe, Akira Sato, Tomoya Hoshi, Noriyuki Takeyasu, Daisuke Abe, Daiki Akiyama, Yuki Kakefuda, Hidetaka Nishina, Yuichi Noguchi, Kazutaka Aonuma
BACKGROUND: The association between contrast-induced acute kidney injury (CI-AKI) and chronic kidney disease (CKD) in patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) has not been fully reported. We evaluated the association of CI-AKI on cardiovascular events in ACS patients with CKD. METHODS: A total of 1059 ACS patients who underwent emergent PCI in our multicenter registry were enrolled (69±12 years, 804 men, 604 STEMI patients)...
June 1, 2014: International Journal of Cardiology
Khurshid Ahmed, Myung Ho Jeong, Rabin Chakraborty, Sumera Ahmed, Young Joon Hong, Doo Sun Sim, Keun Ho Park, Ju Han Kim, Youngkeun Ahn, Jung Chaee Kang, Myeong Chan Cho, Chong Jin Kim, Young Jo Kim
BACKGROUND: Chronic kidney disease (CKD) is associated with poor outcomes after percutaneous coronary intervention (PCI). The aim of the study was to compare zotarolimus- and everolimus-eluting stents used during primary PCI in patients with acute myocardial infarction (AMI) and CKD. METHODS: We selected 854 consecutive ST-elevation MI patients with CKD (estimated glomerular filtration rate <60 mL/min/1.73 m(2)) undergoing primary PCI who were followed up for 12 months...
October 2014: Journal of Cardiology
Beata Franczyk-Skóra, Anna Gluba, Maciej Banach, Jacek Rysz
Renal dysfunction is frequent in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Chronic kidney disease (CKD) is associated with very poor prognosis and is an independent predictor of early and late mortality and major bleeding in patients with NSTE-ACS. Patients with NSTE-ACS and CKD are still rarely treated according to guidelines. Medical registers reveal that patients with CKD are usually treated with too high doses of antithrombotics, especially anticoagulants and inhibitors of platelet glycoprotein (GP) IIb/IIIa receptors, and therefore they are more prone to bleeding...
December 30, 2013: Archives of Medical Science: AMS
Yoann Bataille, Guillaume Plourde, Jimmy Machaalany, Eltigani Abdelaal, Jean-Pierre Déry, Eric Larose, Ugo Déry, Bernard Noël, Gérald Barbeau, Louis Roy, Olivier Costerousse, Olivier F Bertrand
Chronic total occlusion (CTO) in a non-infarct-related artery and chronic kidney failure (CKD) are associated with worse outcomes after primary percutaneous coronary intervention (PCI). The aim of this study was to investigate the interaction of CTO and CKD in patients who underwent primary PCI for acute ST-segment elevation myocardial infarction (STEMI). Patients with STEMIs with or without CKD, defined as an estimated glomerular filtration rate <60 ml/min/1.73 m(2), were categorized into those with single-vessel disease and those with multivessel disease with or without CTO...
July 15, 2013: American Journal of Cardiology
Sofie A Gevaert, Dirk De Bacquer, Patrick Evrard, Marc Renard, Christophe Beauloye, Patrick Coussement, Herbert De Raedt, Peter R Sinnaeve, Marc J Claeys
BACKGROUND: Mortality in female patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary angioplasty (pPCI) is higher than in men. We examined gender differences in the prevalence and prognostic performance of renal dysfunction at admission in this setting. METHODS: A multicenter retrospective sub-analysis of the Belgian STEMI-registry identified 1,638 patients (20.6% women, 79.4% men) treated with pPCI in 8 tertiary care hospitals (January 2007-February 2011)...
2013: BMC Nephrology
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