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Iva Hojsak, Valentina Fabiano, Tudor Lucian Pop, Olivier Goulet, Gian Vincenzo Zuccotti, Fugen Cullu Çokuğraş, Massimo Pettoello-Mantovani, Sanja Kolaček
AIM: The use of probiotics has been covered by many guidelines, position papers and evidence-based recommendations, but few have referred to specific patient groups or clinical indications. This European study summarises recommendations and scientifically credited guidelines on the use of probiotics for children and provides practice points. METHODS: An expert panel was convened by the European Paediatric Association in June 2017 to define the relevant clinical questions for using probiotics in paediatric healthcare and review and summarise the guidelines, recommendations, position papers and high-quality evidence...
February 15, 2018: Acta Paediatrica
Amin Ramezani, Abbas Ghaderi
Targeted therapy using monoclonal antibodies (mAbs) against epidermal growth factor receptor-2 (ErbB2) has been utilized for the treatment of breast cancer, recently. Pertuzumab, one of the anti-ErbB2 mAbs, was approved by FDA in 2012 for the treatment of metastatic breast cancer. The aim of this study was to produce biosimilar version of pertuzumab in Chinese hamster ovary (CHO)-S cell line, and compare its ErbB2-binding and biological activities, with commercial drug, Perjeta. To this end, a dihydrofolate reductase (DHFR)-based strategy was used to produce a CHO-S stable cell pool capable of producing high levels of pertuzumab...
February 13, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Maria Lorella Gianni, Paola Roggero, Charlotte Baudry, Catherine Fressange-Mazda, Claudio Galli, Carlo Agostoni, Pascale le Ruyet, Fabio Mosca
BACKGROUND: When breastfeeding is not possible, infants are fed formulas (IF) in which lipids are usually of plant origin. However, the use of dairy fat in combination with plant oils enables a lipid profile closer to breast milk in terms of fatty acid (FA) composition, triglyceride structure, polar lipids and cholesterol contents. The objective of this study was to determine the effect of an IF containing a mix of dairy fat and plant oils on Omega-3 FA content in red blood cells (RBC)...
February 13, 2018: BMC Pediatrics
B Koçer, M Bozkurt, G Ege, A E Tüzün, R Konak, O Olgun
1. The aim of this study was to identify a feeding regimen that encourages good pasture use in slow (SG) and fast (FG) growing broiler genotypes under free-range management. 2. SG and FG birds fed on either an ad libitum (ADB) or a meal feeding (MEF) programme was given free outdoor access with or without fresh alfalfa from d 22 to 72 and from d 22 to 45, respectively. In two consecutive trials, 800 birds of each genotype were included in a factorial design using groups of 40 birds replicated 5 times. 3. Fresh alfalfa consumption did not improve growth performance and meat quality attributes, whereas the feeding regimen had significant implications...
February 12, 2018: British Poultry Science
Natacha Colliou, Yong Ge, Minghao Gong, Mojgan Zadeh, Jing Li, Francis Alonzo, Mansour Mohamadzadeh
Regulation of Th17 and Th1 cell responses against intracellular pathogens, including Listeria monocytogenes (L. m), is critical to limit inflammation-induced tissue damage. We recently demonstrated the ability of P. UF1 bacterium derived from the intestinal bacterial commensals of preterm infants fed human breast milk to significantly mitigate pathogen-induced inflammation limiting colonic tissue damage. Here we further elucidated the potential of P. UF1 to also regulate innate and T cells, particularly Th17 and Th1 cells, against systemic L...
February 8, 2018: Gut Microbes
E L Lien, C Richard, D R Hoffman
Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are present in breast milk and play important roles in early infant development. A supply of these fatty acids in infant formula (typically following breast milk as a model with ARA > DHA) is thought to be important since endogenous synthesis is insufficient to maintain tissue levels equivalent to breast-fed infants. Intervention studies assessing the impact of DHA- and ARA-supplemented formulas have resulted in numerous positive developmental outcomes (closer to breast-fed infants) including measures of specific cognition functions, visual acuity, and immune responses...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
E Özalkaya, Z Aslandoğdu, A Özkoral, S Topcuoğlu, G Karatekin
BACKGROUND AND OBJECTIVES: Poor breast milk production is the most frequent cause of breastfeeding failure in preterm babies. The aim of our study is to evaluate the effect of herbal tea mixture containing stinging nettle (Natal, Hipp) on breast milk production and serum prolactin levels of mothers, and weight gain of preterm babies. MATERIALS AND METHODS: We enrolled mothers and their babies who were less than 37 gestational week and less than 2000 g, fed with orogastric tube without any contraindication of enteral feeding in neonatal intensive care unit between November 2010 and June 2011...
January 2018: Nigerian Journal of Clinical Practice
Stephanie Ardell, Martin Offringa, Colleen Ovelman, Roger Soll
BACKGROUND: Vitamin K is necessary for the synthesis of coagulation factors. Term infants, especially those who are exclusively breast fed, are deficient in vitamin K and consequently may have vitamin K deficiency bleeding (VKDB). Preterm infants are potentially at greater risk for VKDB because of delayed feeding and subsequent delay in the colonization of their gastrointestinal system with vitamin K producing microflora, as well as immature hepatic and hemostatic function. OBJECTIVES: To determine the effect of vitamin K prophylaxis in the prevention of vitamin K deficiency bleeding (VKDB) in preterm infants...
February 5, 2018: Cochrane Database of Systematic Reviews
M Lemaire, I Le Huërou-Luron, S Blat
Early nutrition may have long-lasting metabolic impacts in adulthood. Even though breast milk is the gold standard, most infants are at least partly formula-fed. Despite obvious improvements, infant formulas remain perfectible to reduce the gap between breastfed and formula-fed infants. Improvements such as reducing the protein content, modulating the lipid matrix and adding prebiotics, probiotics and synbiotics, are discussed regarding metabolic health. Numerous questions remain to be answered on how impacting the infant formula composition may modulate the host metabolism and exert long-term benefits...
February 5, 2018: Journal of Developmental Origins of Health and Disease
Aimilia Gastounioti, Andrew Oustimov, Meng-Kang Hsieh, Lauren Pantalone, Emily F Conant, Despina Kontos
RATIONALE AND OBJECTIVES: We evaluate utilizing convolutional neural networks (CNNs) to optimally fuse parenchymal complexity measurements generated by texture analysis into discriminative meta-features relevant for breast cancer risk prediction. MATERIALS AND METHODS: With Institutional Review Board approval and Health Insurance Portability and Accountability Act compliance, we retrospectively analyzed "For Processing" contralateral digital mammograms (GE Healthcare 2000D/DS) from 106 women with unilateral invasive breast cancer and 318 age-matched controls...
January 30, 2018: Academic Radiology
Hiroko Kodama
The deficiency or excess intake of trace elements, including zinc, copper, selenium and iodine, has often been reported. Zinc deficiency is often observed in infants fed breast milk with low zinc concentration, individuals administered chelating medicines, athletes and patients with diabetes mellitus, hepatic cirrhosis or nephrosis syndrome. Menkes disease is associated with severe copper deficiency, and there is no effective treatment. Deficiencies of selenium and iodine are observed in patients who receive special formulas of milk and enteral formula with low selenium and iodine concentrations, respectively...
2018: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
Marie-Cécile Alexandre-Gouabau, Thomas Moyon, Véronique Cariou, Jean-Philippe Antignac, El Mostafa Qannari, Mikaël Croyal, Mohamed Soumah, Yann Guitton, Agnès David-Sochard, Hélène Billard, Arnaud Legrand, Cécile Boscher, Dominique Darmaun, Jean-Christophe Rozé, Clair-Yves Boquien
Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother's milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother's breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced "slower" (n = 15, -1...
January 31, 2018: Nutrients
Meilan Xue, Xinqiang Ji, Hui Liang, Ying Liu, Bing Wang, Lingling Sun, Weiwei Li
Recent research studies have shown that the intestinal flora are related to the occurrence and progress of breast cancer. This study investigates the effect of fucoidan on intestinal flora and intestinal barrier function in rats with 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancers. Sixty female Sprague-Dawley rats were randomly assigned to the control group, the model group, and the F1 and F2 groups, which were fed fucoidan at concentrations of 200 and 400 mg per kg bw (body weight), respectively...
January 31, 2018: Food & Function
Wei Wang, Yu Sun, Meng Zhang, Yixin Zhang, Wen Chen, Long Tan, Jun Shen, Zhuo Zhao, Shuhai Lan, Wanqi Zhang
BACKGROUND AND OBJECTIVES: The present study investigated the iodine status of breast milk and breast-fed infants during the first 12 weeks postpartum in Tianjin, China. METHODS AND STUDY DESIGN: A total of 175 pregnant women were recruited before delivery. Their breastmilk and 24-h urine samples were collected at 4, 8, and 12 weeks postpartum; spot urine samples were simultaneously collected from their infants. The iodine content of the samples was measured. RESULTS: The mean breast milk iodine concentrations (BMICs) at 4, 8, and 12 weeks were 221...
2018: Asia Pacific Journal of Clinical Nutrition
Sookyoung Jeon, Katherine M Ranard, Martha Neuringer, Emily E Johnson, Lauren Renner, Matthew J Kuchan, Suzette L Pereira, Elizabeth J Johnson, John W Erdman
Background: Lutein, a yellow xanthophyll, selectively accumulates in primate retina and brain. Lutein may play a critical role in neural and retinal development, but few studies have investigated the impact of dietary source on its bioaccumulation in infants. Objective: We explored the bioaccumulation of lutein in infant rhesus macaques following breastfeeding or formula-feeding. Methods: From birth to 6 mo of age, male and female rhesus macaques (Macaca mulatta) were either breastfed (BF) (n = 8), fed a formula supplemented with lutein, zeaxanthin, β-carotene, and lycopene (237, 19...
January 1, 2018: Journal of Nutrition
Nadiah Abu, Nur Rizi Zamberi, Swee Keong Yeap, Noraini Nordin, Nurul Elyani Mohamad, Muhammad Firdaus Romli, Nurulfazlina Edayah Rasol, Tamilselvan Subramani, Nor Hadiani Ismail, Noorjahan Banu Alitheen
BACKGROUND: Morinda citrifolia L. that was reported with immunomodulating and cytotoxic effects has been traditionally used to treat multiple illnesses including cancer. An anthraquinone derived from fruits of Morinda citrifolia L., nordamnacanthal, is a promising agent possessing several in vitro biological activities. However, the in vivo anti-tumor effects and the safety profile of nordamnacanthal are yet to be evaluated. METHODS: In vitro cytotoxicity of nordamnacanthal was tested using MTT, cell cycle and Annexin V/PI assays on human MCF-7 and MDA-MB231 breast cancer cells...
January 27, 2018: BMC Complementary and Alternative Medicine
F Mosca, L Zaniboni, S Stella, C A Kuster, N Iaffaldano, S Cerolini
The study aimed to characterize meat quality traits of Milanino chickens reared according to a specific free-range farming program. A total of 120 birds was reared straight-run in outdoor pens (8 m2/bird) from 35 d of life and fed ad libitum a low (16%) protein diet. At 180 d of age, 20 birds (10 birds/sex) were slaughtered, and carcass weight data were recorded. After processing, carcasses were refrigerated at 4°C for 24 hours. Then, the right breast and thigh with skin were collected and color parameters, pH, water-holding capacity (WHC), and chemical composition were determined...
January 22, 2018: Poultry Science
Junmei Huang, Zhen Zhang, Yuanjue Wu, Yan Wang, Jing Wang, Li Zhou, Zemin Ni, Liping Hao, Nianhong Yang, Xuefeng Yang
BACKGROUND: The relation between infant feeding and growth has been extensively evaluated, but studies examining the volume of formula milk consumption on infant growth are limited. This study aimed to examine the effects of early feeding of larger volumes of formula on growth and risk of overweight in later infancy. METHODS: In total, 1093 infants were studied prospectively. Milk records collected at 3 mo of age were used to define the following 3 feeding groups: breast milk feeding (BM, no formula), lower-volume formula milk feeding (LFM, <840 ml formula/d), and higher-volume formula milk feeding (HFM, ≥840 ml formula/d)...
January 24, 2018: Nutrition Journal
C A Pontin, S L Vieira, C Stefanello, M Kipper, L Kindlein, C T Simões, R Gonzalez-Esquerra
As the first limiting amino acid in corn-soy broiler diets, methionine (Met) is supplemented using commercial synthetic sources as demanded to obtain economic feed formulations. The Met analogue DL-2-hydroxy-4-(methylthio)-butanoic acid (HMTBA) is largely utilized with that objective. This study intended to obtain responses of broilers fed with increasing levels of HMTBA, from 28 to 42 d, such that economic returns can be calculated. A total of 2,106 Cobb × Cobb 500 one-day-old male broilers was randomly placed in 81 floor pens (2...
January 20, 2018: Poultry Science
Junshu Yan, Peifeng Liu, Liangmei Xu, Hailin Huan, Weiren Zhou, Xiaoming Xu, Zhendan Shi
The goal of this experiment was to examine effects of diets supplemented with exogenous inosine monophosphate (IMP) on the growth performance, flavor compounds, enzyme activity and gene expression of chicken. A total of 1,500 healthy, 1-day-old male 3-yellow chickens were used for a 52-d experimental period. Individuals were randomly divided into 5 groups (group I, II, III, IV, V) with 6 replicates per group, and fed a basal diet supplemented with 0.0, 0.05, 0.1, 0.2, and 0.3% IMP, respectively. There was no significant response to the increasing dietary IMP level in average daily feed intake (ADFI), average daily gain (ADG), and feed:gain ratio (F/G) (P ≥ 0...
January 18, 2018: Poultry Science
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