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https://www.readbyqxmd.com/read/29053811/effects-of-the-supplemental-chromium-form-on-performance-and-oxidative-stress-in-broilers-exposed-to-heat-stress
#1
N Sahin, A Hayirli, C Orhan, M Tuzcu, F Akdemir, J R Komorowski, K Sahin
This experiment was conducted to investigate effects of the organic complex form of supplemental chromium (Cr) on performance, oxidative stress markers, and serum profile in broilers exposed to heat stress (HS). A total of 1,200 10-day-old boilers (Ross-308) was divided into one of the 6 treatments (2 environmental temperatures x 3 diets with different Cr forms). The birds were kept in temperature-controlled rooms at either 22 ± 2°C 24 h/d (thermoneutral, TN group) or 34 ± 2°C for 8 h/d, 08:00 to 17:00 h, followed by 22°C for 16 h (HS group) and fed either a basal diet (C) or the basal diet supplemented with Cr (200 μg/kg) through 1...
September 20, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050416/feeding-broiler-breeders-a-reduced-balanced-protein-diet-during-the-rearing-and-laying-period-impairs-reproductive-performance-but-enhances-broiler-offspring-performance
#2
J Lesuisse, C Li, S Schallier, J Leblois, N Everaert, J Buyse
Mammalian studies have shown that nutritional constraints during the perinatal period are able to program the progeny (metabolism, performance). The presented research aimed to investigate if broiler breeders and their offspring performance could be influenced by reducing the dietary crude protein (CP) level with 25%. A total of 160 day-old pure line A breeder females were randomly divided over 2 dietary treatments. The control group was fed commercial diets, whereas the reduced balanced protein (RP) breeders received an isoenergetic diet that was decreased with 25% in dietary CP and amino acid during their entire lifespan...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29042292/obesity-enhances-carcinogen-7-12-dimethylbenz-a-anthracene-induced-tumorigenesis-in-vitro-and-in-vivo
#3
Chia-Chien Hsieh, Shih-Han Peng, Mei-Jia Chou
Growing body of evidence shows that extra adiposity influences on the progression of multiple cancers, including breast cancer. The aim of this study is to investigate whether obesity correlates with mammary tumor development in vitro and in vivo. We found that obesity-related mediators, 3T3-L1 adipocyte conditioned medium, enhanced formation of cancerous foci induced by the carcinogen 7,12-Dimethylbenz[a]anthracene (DMBA) in NIH/3T3 fibroblasts, in vitro. Additionally, we tested the effect of obesity in mouse model of DMBA-induced breast cancer...
October 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29039296/effect-of-human-milk-formula-with-bovine-colostrum-supplementation-on-bone-mineral-density-in-infant-cynomolgus-macaques
#4
N Tay, Y C Tan, K Chng, C Libedinsky, P Gluckman, J P Buschdorf
Insulin-like growth factor 1 (IGF1) is a regulator of human growth during infancy and childhood, known to promote bone and muscle growth as well as lipid accumulation. This study aimed to investigate the effects of formula milk with or without IGF1 supplementation (in the form of pure IGF1 or bovine colostrum) on growth and body composition in infant cynomolgus macaques during the first 6 months of life. Three groups of infants were nursery-reared and received formula milk with or without IGF1 or bovine colostrum supplementation for 4 months, and a fourth group consisting of breast-fed infants was included for comparison (n=6 for each group)...
October 17, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29032404/dietary-supplementation-with-methylseleninic-acid-inhibits-mammary-tumorigenesis-and-metastasis-in-male-mmtv-pymt-mice
#5
Sneha Sundaram, Lin Yan
Male breast cancer, which makes up approximately 1% of all breast cancers, is an aggressive disease with poor prognosis. We investigated the effects of dietary supplementation with selenium in the form of methylseleninic acid [(MSeA) 2.5 mg selenium/kg] on mammary tumorigenesis in male MMTV-PyMT mice. The mammary tumor latency was 14.6 weeks for the MSeA-fed group and 13.8 weeks for the controls fed the AIN93G diet (p < 0.05). Dietary supplementation with MSeA, versus the control, resulted in a 72% reduction in tumor progression, a 46% reduction in both final volume and weight of mammary tumors, and a 70% reduction in the number of lung metastases...
October 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29031099/shear-wave-elastography-for-characterization-of-breast-lesions-shearlet-transform-and-local-binary-pattern-histogram-techniques
#6
U Rajendra Acharya, Wei Lin Ng, Kartini Rahmat, Vidya K Sudarshan, Joel E W Koh, Jen Hong Tan, Yuki Hagiwara, Arkadiusz Gertych, Farhana Fadzli, Chai Hong Yeong, Kwan Hoong Ng
Shear wave elastography (SWE) examination using ultrasound elastography (USE) is a popular imaging procedure for obtaining elasticity information of breast lesions. Elasticity parameters obtained through SWE can be used as biomarkers that can distinguish malignant breast lesions from benign ones. Furthermore, the elasticity parameters extracted from SWE can speed up the diagnosis and possibly reduce human errors. In this paper, Shearlet transform and local binary pattern histograms (LBPH) are proposed as an original algorithm to differentiate malignant and benign breast lesions...
October 2, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29029506/bitter-melon-extract-inhibits-breast-cancer-growth-in-preclinical-model-by-inducing-autophagic-cell-death
#7
Naoshad Muhammad, Robert Steele, T Scott Isbell, Nancy Philips, Ratna B Ray
Breast cancer is a major public health problem worldwide in women and current therapeutic strategies are not adequately effective for this deadly disease. We have previously shown the anti-proliferative activity of bitter melon extract (BME) in breast cancer cells. In this study, we observed that BME treatment induces autophagosome-bound Long chain 3 (LC3)-B and accumulates protein p62/SQSTM1 (p62) in breast cancer cells. Additionally, we observed that BME treatment in breast cancer cells increases phospho-AMPK expression and inhibits the mTOR/Akt signaling pathway...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29026270/longitudinal-study-on-the-effectiveness-of-vitamin-d-supplements-in-exclusively-breast-fed-infants
#8
Shintaro Terashita, Taichi Nakamura, Noboru Igarashi
Vitamin D deficiency is a common health problem in infancy. Breast-fed infants are at a higher risk of rickets than formula-fed infants. We observed fluctuations in vitamin D levels in infancy (phase I, 2009-2010) and considered the benefits of vitamin D supplementation specifically in exclusively breast-fed infants in Japan (phase II, 2015). Infants born at our hospital were enrolled in this study. In phase I, we measured 25-hydroxyvitamin D [25(OH)D] levels at 1- to 6-mo intervals from birth. In phase II, we measured 25(OH)D levels before and after supplementation...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29024822/pubertally-initiated-high-fat-diet-promotes-mammary-tumorigenesis-in-obesity-prone-fvb-mice-similarly-to-obesity-resistant-balb-c-mice
#9
Yirong Zhu, Mark D Aupperlee, Sandra Z Haslam, Richard C Schwartz
Premenopausal breast cancer is associated with increased animal fat consumption among normal-weight but not overweight women. Our previous findings in obesity-resistant BALB/c mice showed that a diet high in saturated animal fat (HFD) promotes mammary tumorigenesis in both DMBA carcinogenesis and Trp53-null transplant models. Having made these observations in BALB/c mice, which have very modest HFD weight gain, we determined the effects of HFD in FVB mice, which gain significant weight on HFD. Three-week-old FVB mice fed a low-fat diet or HFD were subjected to 7,12-dimethylbenz[a]anthracene-induced carcinogenesis...
October 9, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29023517/developmental-delay-in-the-amazon-the-social-determinants-and-prevalence-among-rural-communities-in-peru
#10
Christopher Westgard, Yossef Alnasser
The consequences of poor child development are becoming increasingly recognized. Programs are being put in place around the world to improve child development by providing healthy and stimulating environments for children. However, these programs often have limited reach and little is known about the prevalence of developmental delay in under-developed communities. The current study set-out to better understand the prevalence of developmental delay in rural communities in the Amazon region of Peru. Also, it explores social determinants that are associated with any delay...
2017: PloS One
https://www.readbyqxmd.com/read/29018787/cesarean-section-formula-feeding-and-infant-antibiotic-exposure-separate-and-combined-impacts-on-gut-microbial-changes-in-later-infancy
#11
Farzana Yasmin, Hein Min Tun, Theodore Brian Konya, David S Guttman, Radha S Chari, Catherine J Field, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Malcolm R Sears, James A Scott, Irina Dinu, Anita L Kozyrskyj
Established during infancy, our complex gut microbial community is shaped by medical interventions and societal preferences, such as cesarean section, formula feeding, and antibiotic use. We undertook this study to apply the significance analysis of microarrays (SAM) method to quantify changes in gut microbial composition during later infancy following the most common birth and postnatal exposures affecting infant gut microbial composition. Gut microbiota of 166 full-term infants in the Canadian Healthy Infant Longitudinal Development birth cohort were profiled using 16S high-throughput gene sequencing...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28992839/-symptomatic-zinc-deficiency-in-a-breast-fed-infant
#12
EDITORIAL
Lone Hvid, Gitte Zachariassen, Karina Dyrvig Honoré, Anne Birgitte Simonsen
Nutrition containing zinc is of special practical importance in infants and children. Perinatal zinc deficiency manifestations include erosive dermatitis, alopecia, diarrhoea, central nervous system dysfunction and immune system deficiency. We present a case story of an ex-preterm, exclusively breast-fed infant who presented with irritability, clinical signs of infection, an atypical rash and signs of oral candidiasis. Blood tests showed low plasma levels of zinc and subsequent analysis showed reduced zinc levels in the breast milk...
October 9, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28991311/selenium-fortification-of-infant-formulas-does-selenium-form-matter
#13
REVIEW
Bo Lönnerdal, Eugenia Vargas-Fernández, Mark Whitacre
Selenium is a trace element essential for the health and development of the growing infant. It is a necessary component of proteins and enzymes required for a variety of functions, including antioxidant defense, modulation of the inflammatory response, and production of thyroid hormones. In breast-fed infants, selenium stores depend on the selenium content of the mother's diet. In formula-fed infants, selenium levels are correlated to the residual selenium stores accumulated in utero and the level and type of selenium fortification used in the formula...
October 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28969890/lactobacillus-reuteri-for-infants-with-colic-a-double-blind-placebo-controlled-randomized-clinical-trial
#14
Nicole Y Fatheree, Yuying Liu, Christopher M Taylor, Thomas K Hoang, Chunyan Cai, Mohammad H Rahbar, Manouchehr Hessabi, Michael Ferris, Valarie McMurtry, Christine Wong, Ta Vu, Theresa Dancsak, Ting Wang, Wallace Gleason, Vinay Bandla, Fernando Navarro, Dat Q Tran, J Marc Rhoads
OBJECTIVE: To assess the safety of probiotic Lactobacillus reuteri strain Deutsche Sammlung von Mikroorganismen (DSM) 17938 with daily administration to healthy infants with colic and to determine the effect of L reuteri strain DSM 17938 on crying, fussing, inflammatory, immune, and microbiome variables. STUDY DESIGN: We performed a controlled, double-blinded, phase 1 safety and tolerability trial in healthy breast-fed infants with colic, aged 3 weeks to 3 months, randomly assigned to L reuteri strain DSM 17938 (5 × 10(8) colony-forming units daily) or placebo for 42 days and followed for 134 days...
September 29, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28968868/international-multi-centre-study-of-pregnancy-outcomes-with-interleukin-1-inhibitors
#15
Taryn Youngstein, Patrycja Hoffmann, Ahmet Gül, Thirusha Lane, Rene Williams, Dorota M Rowczenio, Huri Ozdogan, Serdal Ugurlu, John Ryan, Len Harty, Sean Riminton, Alex P Headley, Joachim Roesler, Norbert Blank, Jasmin B Kuemmerle-Deschner, Anna Simon, Adrian S Woolf, Philip N Hawkins, Helen J Lachmann
Objective: To provide outcome data concerning pregnancies exposed to the Interleukin-1 (IL-1) inhibitors prior to conception in both men and women, during pregnancy and breast feeding. Methods: Retrospective data were collected from members of the International Society for Systemic Autoinflammatory diseases and collated in a single centre. A uniform data collection sheet was used to obtain standardized data including maternal age and diagnosis, type, duration of and response to IL-1 blockade, pregnancy duration, delivery, mode of feeding and neonatal development...
August 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968536/tumor-vasculature-normalization-by-orally-fed-erlotinib-to-modulate-the-tumor-microenvironment-for-enhanced-cancer-nanomedicine-and-immunotherapy
#16
Qian Chen, Ligeng Xu, Jiawen Chen, Zhijuan Yang, Chao Liang, Yu Yang, Zhuang Liu
The abnormal tumor vasculature is one of key reasons that lead to the limited tumor perfusion as well as hypoxic and immunosuppressive tumor microenvironment (TME). Herein, we uncover that by normalizing the tumor vasculature with erlotinib, a specific inhibitor of epidermal growth factor receptor (EGFR), the tumor perfusion and tumor oxygenation statuses in different types of tumors including murine breast tumors, colorectal tumors, and squamous cell carcinoma tumors, could be remarkably enhanced. As the results, the tumor uptake of drug-loaded nanoparticles as well as their interstitial penetration within the tumor would be greatly increased for mice pre-treated with erlotinib at the oral feeding dose of 50 mg/kg, leading to remarkably improved chemotherapeutic efficacy of nanomedicine...
December 2017: Biomaterials
https://www.readbyqxmd.com/read/28964928/evaluation-of-estrogenic-potency-of-a-standardized-hops-extract-on-mammary-gland-biology-and-on-mnu-induced-mammary-tumor-growth-in-rats
#17
Annekathrin M Keiler, Dana Macejova, Birgit M Dietz, Judy L Bolton, Guido F Pauli, Shao-Nong Chen, Richard B van Breemen, Dejan Nikolic, Florian Goerl, Michael H Muders, Oliver Zierau, Günter Vollmer
Supplements with estrogenic activities are intensively investigated as potential alternatives for the treatment of menopausal symptoms. These investigations include studies on their safety regarding potential breast cancer risks. Therefore, the aim of this study was to assess whether or not a standardized hops (Humulus lupulus) extract, containing 0.42% of the estrogenic flavanone, 8-prenylnaringenin, would stimulate growth of methyl-nitrosourea (MNU) induced mammary cancer in ovariectomized (OVX) Sprague-Dawley (SD) rats or would impact on the proliferative activity within the normal mammary gland of Wistar rats...
September 27, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28960522/near-infrared-spectroscopy-is-a-promising-non-invasive-technique-for-monitoring-the-effects-of-feeding-regimens-on-the-cerebral-and-splanchnic-regions
#18
Alice Grometto, Benedetta Pizzo, Maria Chiara Strozzi, Francesca Gazzolo, Diego Gazzolo
AIM: The effects of different milk and, or, administration regimens on cerebro-splanchnic perfusion are still a matter of debate. We investigated the effects of the bolus administration of breast milk or formula on cerebro-splanchnic oximetry, function and perfusion, assessed by near-infrared spectroscopy (NIRS). METHODS: This observational study of 30 infants fed with breast (n=15) or formula (n=15) milk, and matched for gestational age and birth weight, was carried out in the neonatal intensive care unit of the C Arrigo Children's Hospital, Alessandria, Italy, a tertiary level referral centre, from October 2015 to December 2016...
September 27, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28955104/parturients-awareness-and-perception-of-benefits-of-breast-feeding-in-the-prevention-of-infant-and-childhood-oral-and-dental-diseases
#19
Charles E Anyanechi, Kufre J Ekabua, Ansa B Ekpenyong, John E Ekabua
BACKGROUND: Breastfed babies have a better chance of improved oral and dental health than their counterparts that were artificially-fed. OBJECTIVE: To assess the knowledge and attitude of postnatal mothers on the benefits of breastfeeding in prevention of oral and dental diseases. MATERIALS AND METHODS: A cross - sectional descriptive survey of 206 mothers attending the postnatal clinic of the University of Calabar Teaching Hospital, Calabar on the knowledge and attitude of breastfeeding in prevention of oral diseases in infants...
June 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/28954839/young-pigs-consuming-lysozyme-transgenic-goat-milk-are-protected-from-clinical-symptoms-of-enterotoxigenic-escherichia-coli-infection
#20
Lydia C Garas, Caitlin A Cooper, Matthew W Dawson, Jane-Ling Wang, James D Murray, Elizabeth A Maga
Background: Diarrheal diseases in infancy and childhood are responsible for substantial morbidity and mortality in developing nations. Lysozyme, an antimicrobial component of human milk, is thought to play a role in establishing a healthy intestinal microbiota and immune system. Consumption of breast milk has been shown to prevent intestinal infections and is a recommended treatment for infants with diarrhea.Objective: This study aimed to examine the ability of lysozyme-rich goat milk to prevent intestinal infection...
September 27, 2017: Journal of Nutrition
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