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https://www.readbyqxmd.com/read/29758126/abrogating-fibrinolysis-does-not-improve-bleeding-or-rfviia-rfviii-treatment-in-a-non-mucosal-venous-injury-model-in-haemophilic-rodents
#1
Rikke Stagaard, Matthew J Flick, Barbara Bojko, Krzysztof Goryński, Paulina Z Goryńska, Carsten D Ley, Lisbeth H Olsen, Tom Knudsen
BACKGROUND: Fibrinolysis may exacerbate bleeding in haemophilia A (HA). Accordingly, antifibrinolytics have been used to help maintain haemostatic control. While antifibrinolytic drugs have been proven effective in the treatment of mucosal bleeds in the oral cavity, their efficacy in non-mucosal tissues remain an open question of significant clinical interest. OBJECTIVE: To determine whether inhibiting fibrinolysis improves the outcome in non-mucosal haemophilic tail vein transection (TVT) bleeding models, and to determine whether a standard ex vivo clotting/fibrinolysis assay can be used as a predictive surrogate for in vivo efficacy...
May 14, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29749111/probing-the-viscoelastic-property-of-pseudo-free-standing-conjugated-polymeric-thin-films
#2
Song Zhang, Michael U Ocheje, Shaochuan Luo, Dakota Ehlenberg, Benjamin Appleby, Daniel Weller, Dongshan Zhou, Simon Rondeau-Gagné, Xiaodan Gu
The understanding of the structure-mechanical property relationship for semiconducting polymers is essential for the application of flexible organic electronics. Herein pseudo free-standing tensile testing, a technique that measures the mechanical property of thin films floating on the surface of water, is used to obtain the stress-strain behaviors of two semiconducting polymers, poly(3-hexylthiophene) (P3HT) and poly(2,5-bis(2-decyltetradecyl)-3,6-di(thiophen-2-yl)diketopyrrolo[3,4-c]pyrrole-1,4-dione-alt-thienovinylthiophene (DPP-TVT) donor-acceptor (D-A) polymer...
May 11, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29741482/mortality-risk-after-transcatheter-aortic-valve-implantation-analysis-of-the-predictive-accuracy-of-the-transcatheter-valve-therapy-registry-risk-assessment-model
#3
Pablo Codner, Waqas Malick, Remi Kouz, Amisha Patel, Cheng-Han Chen, Juan Terre, Uri Landes, Torsten Peter Vahl, Isaac George, Tamim Nazif, Ajay J Kirtane, Omar K Khalique, Rebecca T Hahn, Martin B Leon, Susheel Kodali
AIMS: Risk assessment tools currently used to predict mortality in transcatheter aortic valve implantation (TAVI) were designed for patients undergoing cardiac surgery. We aim to assess the accuracy of the TAVI dedicated American College of Cardiology / Transcatheter Valve Therapies (ACC/TVT) risk score in predicting mortality outcomes. METHODS AND RESULTS: Consecutive patients (n=1038) undergoing TAVI at a single institution from 2014 to 2016 were included. The ACC/TVT registry mortality risk score, the Society of Thoracic Surgeons - Patient Reported Outcomes (STS-PROM) score and the EuroSCORE II were calculated for all patients...
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29704816/the-role-of-macroplastique-implantation-in-the-management-of-occult-urinary-stress-incontinence
#4
Roberto Montera, Giuseppe Scaletta, Francesco Plotti, Salvatore Lopez, Daniela Luvero, Stella Capriglione, Alessia Aloisi, Alessandra Gatti, Carlo De Cicco Nardone, Raffaella Carassiti, Corrado Terranova, Roberto Angioli
OBJECTIVE: Pelvic floor disorders, in particular pelvic organ prolapse (POP) and stress urinary incontinence (SUI), are common in women. There is a described higher risk to develop postoperative SUI also in preoperatively continent women: this happens because in 30% of women the relief of the urethral obstruction caused by prolapse, unmasks a pre-existing compromised urethral function and thus an "occult" or potential SUI. The aims of this study were to evaluate the role of Macroplastique® implant, TVT-O or surgery alone in the management of occult urinary stress incontinence during prolapse surgery in terms of success rate and adverse events...
April 21, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29697545/transcatheter-valvular-interventions-in-2017-some-things-old-some-things-new
#5
Hasan Rehman, Neal S Kleiman, Ankur Kalra
PURPOSE OF REVIEW: Transcatheter valvular interventions have changed the landscape of valvular therapies. We examine some studies on transcatheter valvular interventions published in the year 2017 to better understand their implications on clinical practice and future research. RECENT FINDINGS: Findings from the SURTAVI study suggest TAVR to be a reasonable option in intermediate risk patients with aortic stenosis. Recent studies indicate that valve leaflet thrombosis is associated with poor outcomes...
April 24, 2018: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29673676/did-surgical-failure-and-complications-affect-incontinence-related-quality-of-life-in-women-after-transobturator-sling-procedure
#6
Wen-Chu Huang, Hui-Hsuan Lau, Tsung-Hsien Su
OBJECTIVE: To report the objective outcome, subjective measurement of incontinence-related quality of life (QoL) for female urodynamic stress incontinence (USI) after transobturator sling surgery (TVT-O) and to evaluate the effects of surgical failure and complications on QoL. MATERIALS AND METHODS: We analyzed the data from women who underwent TVT-O for USI and completed two validated QoL questionnaires, the Urogenital Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) preoperatively and at least 12 months postoperatively...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29622149/prevalence-and-outcomes-of-mitral-stenosis-in-patients-undergoing-transcatheter-aortic-valve-replacement-findings-from-the-society-of-thoracic-surgeons-american-college-of-cardiology-transcatheter-valve-therapies-registry
#7
Lee Joseph, Mohammad Bashir, Qun Xiang, Babatunde A Yerokun, Roland Albert Matsouaka, Sreekanth Vemulapalli, Samir Kapadia, Joaquin E Cigarroa, Firas Zahr
OBJECTIVES: This study sought to examine the prevalence of mitral stenosis (MS) and its impact on in-hospital and 1-year clinical outcomes among patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: Patients with coexisting severe aortic stenosis and MS are increasingly being considered for TAVR. METHODS: The study cohort included 44,755 patients (age ≥18 years) who underwent TAVR during November 1, 2011, to September 30, 2015, and were registered in Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies (TVT) Registry...
April 9, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29566805/inclusion-of-functional-status-measures-in-the-risk-adjustment-of-30-day-mortality-after-transcatheter-aortic-valve-replacement-a-report-from-the-society-of-thoracic-surgeons-american-college-of-cardiology-tvt-registry
#8
Suzanne V Arnold, Sean M O'Brien, Sreekanth Vemulapalli, David J Cohen, Amanda Stebbins, J Matthew Brennan, David M Shahian, Fred L Grover, David R Holmes, Vinod H Thourani, Eric D Peterson, Fred H Edwards
OBJECTIVES: The aim of this study was to develop and validate a risk adjustment model for 30-day mortality after transcatheter aortic valve replacement (TAVR) that accounted for both standard clinical factors and pre-procedural health status and frailty. BACKGROUND: Assessment of risk for TAVR is important both for patient selection and provider comparisons. Prior efforts for risk adjustment have focused on in-hospital mortality, which is easily obtainable but can be biased because of early discharge of ill patients...
March 26, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29489322/medium-bandgap-small-molecule-donors-compatible-with-both-fullerene-and-nonfullerene-acceptors
#9
Yong Huo, Cenqi Yan, Bin Kan, Xiao-Fei Liu, Li-Chuan Chen, Chen-Xia Hu, Tsz-Ki Lau, Xinhui Lu, Chun-Lin Sun, Xiangfeng Shao, Yongsheng Chen, Xiaowei Zhan, Hao-Li Zhang
Much effort has been devoted to the development of new donor materials for small-molecule organic solar cells due to their inherent advantages of well-defined molecular weight, easy purification, and good reproducibility in photovoltaic performance. Herein, we report two small-molecule donors that are compatible with both fullerene and nonfullerene acceptors. Both molecules consist of an (E)-1,2-di(thiophen-2-yl)ethane-substituted (TVT-substituted) benzo[1,2-b:4,5-b']dithiophene (BDT) as the central unit, and two rhodanine units as the terminal electron-withdrawing groups...
March 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29478148/a-new-treatment-of-female-stress-urinary-incontinence-with-vaginal-antetheca-retropubic-space-mesh-repair-surgery-a-clinical-trial
#10
Geping Yin, Zheng Yuan, Juan Li, Jing Liang, Aifang Wu, Na Liu
PURPOSE: To investigate the short- and medium-term effect of vaginal antetheca submucosal-retropubic space with mesh repair through the implantation of organic patch (shortly as new-style vaginal mesh repair) in the treatment of patients with stress urinary incontinence (SUI). METHODS: This was a clinical prospective single arm study in a tertiary grade hospital (General Hospital of Jinan Military Region, Jinan, China). From January 2009 to December 2014, 316 female patients were enrolled...
February 24, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29468798/tension-free-vaginal-tape-for-treatment-of-pure-urodynamic-stress-urinary-incontinence-efficacy-and-adverse-effects-at-17-year-follow-up
#11
Andrea Braga, Giorgio Caccia, Paola Sorice, Simona Cantaluppi, Anna Chiara Coluccia, Maria Carmela Di Dedda, Luca Regusci, Fabio Ghezzi, Stefano Uccella, Maurizio Serati
OBJECTIVE: To assess the efficacy and safety of retropubic tension-free vaginal tape (TVT) 17 years after implantation for the treatment of female pure stress urinary incontinence (SUI). PATIENTS AND METHODS: A prospective study was conducted in two urogynaecological units in two countries. All consecutive women with urodynamically proven pure SUI treated by TVT were included. Patients with mixed incontinence and/or anatomical evidence of pelvic organ prolapse were excluded...
February 22, 2018: BJU International
https://www.readbyqxmd.com/read/29452779/management-of-female-stress-urinary-incontinence-a-care-pathway-and-update
#12
REVIEW
Giampiero Capobianco, Massimo Madonia, Sonia Morelli, Francesco Dessole, Davide De Vita, Pier Luigi Cherchi, Salvatore Dessole
Stress urinary incontinence (SUI) is a condition characterized by an involuntary loss of urine occurring as result of an increase in intra-abdominal pressure due to effort or exertion or on sneezing or coughing. Estimates of its prevalence in the female population range from 10% to 40%. A literature search of the Medline, Cochrane library, EMBASE, NLH, ClinicalTrials.gov and Google Scholar databases was done up to July 2017, restricted to English-language articles, using terms related to SUI, medical therapy, surgical therapy and treatment options...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29420415/delayed-presentation-of-cecal-perforation-with-tension-free-vaginal-tape
#13
Allison C Mayhew, Alexcis T Ford, Gina M Northington, Virginia O Shaffer, Robert S Kelley
BACKGROUND: Tension-free vaginal tape (TVT) is a popular operative treatment for stress urinary incontinence (SUI). It has a low risk of adverse events, and injuries, particularly to the bowel, are rare. Case reports that have previously discussed these injuries and subsequent removal of TVT have not provided additional insight into management of SUI after these injuries occur. CASE: A postmenopausal woman with persistent SUI presented more than 1 year after TVT placement with bowel perforation incidentally discovered on routine screening colonoscopy...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29393041/surgical-treatment-for-urinary-incontinence-in-women-danish-nationwide-cohort-studies
#14
Margrethe Foss Hansen
This PhD thesis is based on three original articles. The studies were performed at the Department of Obstetrics and Gynaecology, Herlev University Hospital and at the Center for Clinical Epidemiology, Odense University Hospital. 
Urinary incontinence (UI) is a frequent disorder among women, which for the individual can have physical, psychological and social consequences. The current standard of surgical treatment is the synthetic midurethral sling (MUS), which is a minimal invasive procedure.
As the synthetic MUSs (TVT,TVT-O,TOT) were introduced in the late 1990s, there are only a few studies at the long-term follow-up based on nationwide populations; only a few have reported on the risk of reoperation and there is sparse evidence on which treatment should be used subsequently to failure of synthetic MUSs...
February 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29383698/infusion-fill-method-versus-standard-auto-fill-trial-of-void-protocol-following-a-tvt-exact-procedure-a-randomised-controlled-trial
#15
Alexandra Mowat, Bernadette Brown, Anita Pelecanos, Victoria Mowat, Malcolm Frazer
OBJECTIVE: To establish whether the infusion method trial of void (TOV) after a mid-urethral sling procedure, in contrast to the standard auto-fill TOV, permits discharge home from recovery, as these procedures are eminently suited to same day discharge, and the delay in achieving a successful TOV often keeps the patient in hospital overnight. METHOD: A randomised controlled trial performed between December 2014 and April 2016 at the University Hospital, enrolling 40 women undergoing a mid-urethral sling procedure for stress urinary incontinence...
January 31, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29331033/the-efficacy-and-safety-comparison-of-surgical-treatments-for-stress-urinary-incontinence-a-network-meta-analysis
#16
REVIEW
Pan Song, Yibo Wen, Chuiguo Huang, Wancong Wang, Naijun Yuan, Yinliang Lu, Qingwei Wang, Tao Zhang, Jianguo Wen
AIMS: Stress urinary incontinence (SUI) is a common problem worldwide. Mainstream surgical procedures include tension-free vaginal tape (TVT), transobturator tape (TOT), tension-free vaginal tape-obturator (TVT-O), tension-free vaginal tape SECUR (TVT-S), and adjustable single-incision sling (Ajust). The aim of this study was to compare the efficacy and safety of these surgical procedures and assess which surgery is most optimal for SUI by adopting a network meta-analysis (NMA). METHODS: Electronic databases including PubMed, Cochrance Library, and Embase database were researched systematically, until March 21, 2017...
January 13, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29299661/three-and-twelve-month-follow-up-outcomes-of-tvt-exact-and-tvt-abbrevo-for-treatment-of-female-stress-urinary-incontinence-a-randomized-clinical-trial
#17
ShiJian Feng, DeYi Luo, QinYu Liu, TongXin Yang, Caigan Du, Hong Li, KunJie Wang, Hong Shen
OBJECTIVE: To compare the efficacy, safety, postoperative complications and discomforts between TVT-EXACT (TVT-E) and TVT-ABBREVO (TVT-A) for treatment of female stress urinary incontinence. METHODS: Recruited patients were randomized into either TVT-E or TVT-A group using SPSS software. Follow-up measures were performed at day 1 before surgery and both 3 and 12 months after the surgery. The measurement outcomes were the scores of involved six questionnaires on quality of life, symptom severity and patient satisfaction...
March 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29298467/impact-of-preoperative-patient-characteristics-and-flow-rate-on-failure-early-complications-and-voiding-dysfunction-after-a-transobturator-tape-procedure-a-multicentre-study
#18
Andrea Cocci, Giovanni E Cacciamani, Giorgio Ivan Russo, Maria Angela Cerruto, Martina Milanesi, Luis G Medina, Sebastiano Cimino, Walter Artibani, Giuseppe Morgia, Marco Carini, Vincenzo Li Marzi
PURPOSE: To evaluate the impact of preoperative patient characteristics and flow rate on failure, early postoperative complications, and voiding in patients who underwent transvaginal tension-free vaginal tape-obturator (TVT-O) treatment for uncomplicated stress urinary incontinence (SUI). METHODS: We retrospectively reviewed patients who underwent TVT-O for SUI at 3 Italian centres. The exclusion criteria were predominant voiding and storage symptoms suggestive of detrusor overactivity, the presence of grade >1 urogenital prolapse, previous pelvic radiotherapy or other clinical contraindications for surgical procedures, neurogenic bladder dysfunction, and collagen diseases...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29280551/predictors-of-patient-radiation-exposure-during-transcatheter-aortic-valve-replacement
#19
Andrew M Goldsweig, Kevin F Kennedy, Dhaval Kolte, J Dawn Abbott, Paul C Gordon, Barry L Sharaf, Frank W Sellke, Afshin Ehsan, Neel R Sodha, Frank Rutar, Herbert D Aronow
BACKGROUND: Transcatheter aortic valve replacement (TAVR) exposes patients to radiation. OBJECTIVES: We sought to identify factors associated with higher radiation exposure and to quantify their relative influence, which may inform reduction of this hazard. METHODS: All TAVR procedures at Rhode Island Hospital between March 20, 2012 and February 12, 2017 were included. Procedures were performed by two co-primary operators using a Siemens Artis Zeego system...
December 27, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29235849/all-small-molecule-solar-cells-incorporating-ndi-based-acceptors-synthesis-and-full-characterization
#20
Jisu Hong, Yeon Hee Ha, Hyojung Cha, Ran Kim, Yu Jin Kim, Chan Eon Park, James R Durrant, Soon-Ki Kwon, Tae Kyu An, Yun-Hi Kim
A series of naphthalene diimide (NDI)-based small molecules were synthesized as nonfullerene acceptors and incorporated in all-small-molecule solar cells. Three NDI-based small molecules, NDICN-T, NDICN-BT, and NDICN-TVT, were designed with different linkers between two NDI units to induce the different conjugation length and modulate the geometric structures of the NDI dimers. The small NDI-based dimer electron acceptors with slip-stacked structures that facilitate π-π stacking interactions and/or hinder excessive aggregation exhibited different morphological behaviors, such as miscibility or crystallinity in bulk heterojunction blends with 7,7'-(4,4-bis(2-ethylhexyl)-4H-silolo[3,2-b:4,5-b']dithiophene-2,6-diyl)bis(6-fluoro-4-(5'-hexyl-[2,2'-bithiophen]-5-yl)benzo[c][1,2,5]thiadiazole) (DTS-F) electron donors...
December 27, 2017: ACS Applied Materials & Interfaces
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