Krzysztof Badura, Dominika Buławska, Bartłomiej Dąbek, Alicja Witkowska, Wiktoria Lisińska, Ewa Radzioch, Sylwia Skwira, Ewelina Młynarska, Jacek Rysz, Beata Franczyk
Primary electrical heart diseases, often considered channelopathies, are inherited genetic abnormalities of cardiomyocyte electrical behavior carrying the risk of malignant arrhythmias leading to sudden cardiac death (SCD). Approximately 54% of sudden, unexpected deaths in individuals under the age of 35 do not exhibit signs of structural heart disease during autopsy, suggesting the potential significance of channelopathies in this group of age. Channelopathies constitute a highly heterogenous group comprising various diseases such as long QT syndrome (LQTS), short QT syndrome (SQTS), idiopathic ventricular fibrillation (IVF), Brugada syndrome (BrS), catecholaminergic polymorphic ventricular tachycardia (CPVT), and early repolarization syndromes (ERS)...
February 2, 2024: International Journal of Molecular Sciences