keyword
MENU ▼
Read by QxMD icon Read
search

wilde aa[author]

keyword
https://www.readbyqxmd.com/read/27406953/an-analysis-of-170-glioma-patients-and-systematic-review-to-investigate-the-association-between-idh-1-mutations-and-preoperative-glioma-related-epilepsy
#1
Yuan Yang, Qing Mao, Xiang Wang, Yanhui Liu, Yunhe Mao, Qiao Zhou, Jiewen Luo
Seizure is a common presenting symptom of glioma, and many biomarkers have been suggested to be associated with preoperative seizure; however, the relationships between IDH (isocitrate dehydrogenase) mutations and glioma-related epilepsy only recently been studied. The authors aimed to examine the correlations between IDH mutations in glioma patients with preoperative seizures and tumor location. A series of 170 glioma samples were analyzed for IDH1 R132H mutations (amino acid change from arginine to histidine at codon 132) with immunohistochemistry (IHC) staining and for IDH mutations with direct DNA sequencing when the IHC results were negative...
September 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26623630/characterization-of-h5n1-influenza-a-virus-that-caused-the-first-highly-pathogenic-avian-influenza-outbreak-in-saudi-arabia
#2
Ahmed Ali Al-Qahtani, Muhammad Mubin, Fahad N Almajhdi, Saud Alarifi, Damian M Dela Cruz, Muhammad Shah Nawaz Ul Rehman, Mahmoud Moussa Ismail, Nisar Ahmed, Mohamed H Al-Blowi, Hanif Khalak, Mohammed N Al-Ahdal
INTRODUCTION: Saudi Arabia (SA) experienced a highly pathogenic avian influenza (HPAI) H5N1 outbreak in domesticated birds in 2007. METHODOLOGY: Forty-three hemagglutinin (HA) and 41 neuraminidase (NA) genes of HPAI H5N1 viruses were sequenced and phylogenetic analyses of completely sequenced genes were performed to compare with other viral HA and NA gene sequences available in the public databases. RESULTS: Molecular characterization of the H5N1 viruses revealed two genetically distinct clades, 2...
November 30, 2015: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/26462332/the-ts111-mutation-of-paramecium-tetraurelia-affects-a-member-of-the-protein-palmitoylation-family
#3
Małgorzata Prajer, Sebastian Tarcz
The thermosensitive ts111 mutant of Parameciun tetraurelia carries a recessive mutation which causes cell death after 2-8 divisions at the restrictive temperature of 35 degrees C. Expression at 35 degrees C induces disassembly of the infraciliary lattice (ICL). In this study, we found that the ts111 mutation also results in significant abnormalities in the number and structure of contractile vacuole complexes (CVCs) and in their functioning at the restrictive temperature. In order to characterize the ts111 gene, the complementation cloning was performed by microinjection into the macronucleus of an indexed genomic DNA library...
2015: Folia Biologica (Krakow)
https://www.readbyqxmd.com/read/26270939/up-regulation-of-cathepsin-g-in-the-development-of-chronic-postsurgical-pain-an-experimental-and-clinical-genetic-study
#4
Xiaodong Liu, Yuanyuan Tian, Zhaoyu Meng, Yan Chen, Idy H T Ho, Kwong Wai Choy, Peter Lichtner, Sunny H Wong, Jun Yu, Tony Gin, William K K Wu, Christopher H K Cheng, Matthew T V Chan
BACKGROUND: Proteases have been shown to modulate pain signaling in the spinal cord and may contribute to the development of chronic postsurgical pain. By using peripheral inflammation in rats as a chronic pain model, the authors identified the deregulation of proteases and their inhibitors as a hallmark of chronic pain development using a genome-wide screening approach. METHODS: A microarray analysis was performed and identified spinal cathepsin G (CTSG) as the most up-regulated gene in rats with persistent hyperalgesia after intraplantar injection of complete Freund's adjuvant (n = 4)...
October 2015: Anesthesiology
https://www.readbyqxmd.com/read/25738637/syntaxin1a-mediated-resistance-and-hypersensitivity-to-isoflurane-in-drosophila-melanogaster
#5
Oressia H Zalucki, Hareesh Menon, Benjamin Kottler, Richard Faville, Rebecca Day, Adekunle T Bademosi, Nickolas Lavidis, Shanker Karunanithi, Bruno van Swinderen
BACKGROUND: Recent evidence suggests that general anesthetics activate endogenous sleep pathways, yet this mechanism cannot explain the entirety of general anesthesia. General anesthetics could disrupt synaptic release processes, as previous work in Caenorhabditis elegans and in vitro cell preparations suggested a role for the soluble NSF attachment protein receptor protein, syntaxin1A, in mediating resistance to several general anesthetics. The authors questioned whether the syntaxin1A-mediated effects found in these reductionist systems reflected a common anesthetic mechanism distinct from sleep-related processes...
May 2015: Anesthesiology
https://www.readbyqxmd.com/read/25616050/full-genome-sequence-analysis-of-a-wild-non-mlv-related-type-2-hungarian-prrsv-variant-isolated-in-europe
#6
Gyula Balka, Xiong Wang, Ferenc Olasz, Ádám Bálint, István Kiss, Krisztián Bányai, Miklós Rusvai, Tomasz Stadejek, Douglas Marthaler, Michael P Murtaugh, Zoltán Zádori
Porcine reproductive and respiratory syndrome virus (PRRSV) is a widespread pathogen of pigs causing significant economic losses to the swine industry. The expanding diversity of PRRSV strains makes the diagnosis, control and eradication of the disease more and more difficult. In the present study, the authors report the full genome sequencing of a type 2 PRRSV strain isolated from piglet carcasses in Hungary. Next generation sequencing was used to determine the complete genome sequence of the isolate (PRRSV-2/Hungary/102/2012)...
March 16, 2015: Virus Research
https://www.readbyqxmd.com/read/24039206/value-of-immunohistochemistry-in-the-detection-of-braf-v600e-mutations-in-fine-needle-aspiration-biopsies-of-papillary-thyroid-carcinoma
#7
Anne-Katrin Zimmermann, Ulrike Camenisch, Markus P Rechsteiner, Beata Bode-Lesniewska, Matthias Rössle
BACKGROUND: Fine-needle aspiration biopsy (FNAB) is important in the diagnostic establishment of suspicious thyroid nodules. In thyroid neoplasms, mutation of the BRAF gene occurs rather exclusively in papillary thyroid carcinoma (PTC) and results in>98% of the cases in V600E amino acid substitution. In the current study, the authors investigated the diagnostic value of a recently described monoclonal antibody that detects this specific mutation on FNAB specimens from patients with PTC...
January 2014: Cancer Cytopathology
https://www.readbyqxmd.com/read/23955770/the-common-ecotoxicology-laboratory-strain-of-hyalella-azteca-is-genetically-distinct-from-most-wild-strains-sampled-in-eastern-north-america
#8
Kaley Major, David J Soucek, Rosanna Giordano, Mark J Wetzel, Felipe Soto-Adames
The amphipod Hyalella azteca is commonly used as a model for determining safe concentrations of contaminants in freshwaters. The authors sequenced the mitochondrial cytochrome c oxidase subunit I (COI) gene for representatives of 38 populations of this species complex from US and Canadian toxicology research laboratories and eastern North American field sites to determine their genetic relationships. With 1 exception, all US and Canadian laboratory cultures sampled were identified as conspecific. In 22 wild populations spanning 5 US states and 1 Canadian province, the commonly occurring laboratory species was found only in northern Florida, USA...
November 2013: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/23932037/influence-of-cyp2c9-and-vkorc1-genotypes-on-the-risk-of-hemorrhagic-complications-in-warfarin-treated-patients-a-systematic-review-and-meta-analysis
#9
REVIEW
Jie Yang, Yanming Chen, Xiaoqi Li, Xiaowen Wei, Xi Chen, Lanning Zhang, Yuxiao Zhang, Qiang Xu, Hongjuan Wang, Yang Li, Caiyi Lu, Wei Chen, Changqing Zeng, Tong Yin
BACKGROUND: The main challenge for warfarin anticoagulation is the risk for hemorrhagic complications. Although certain pharmacogenetic factors may explain the individual variabilities about the therapeutic warfarin dose requirement, the genetic factors to warfarin hemorrhagic complications due to over-anticoagulation are largely unknown. To interpret the potential role of warfarin-related genotypes on over-anticoagulation and hemorrhagic complications, we conducted a meta-analysis based on 22 published studies...
October 9, 2013: International Journal of Cardiology
https://www.readbyqxmd.com/read/23913529/mutation-of-the-little-finger-domain-in-human-dna-polymerase-%C3%AE-alters-fidelity-when-copying-undamaged-dna
#10
Renee A Beardslee, Samuel C Suarez, Shannon M Toffton, Scott D McCulloch
DNA polymerase η (pol η) synthesizes past cyclobutane pyrimidine dimer and possibly 7,8-dihydro-8-oxoguanine (8-oxoG) lesions during DNA replication. Loss of pol η is associated with an increase in mutation rate, demonstrating its indispensable role in mutation suppression. It has been recently reported that β-strand 12 (amino acids 316-324) of the little finger region correctly positions the template strand with the catalytic core of the enzyme. The authors hypothesized that modification of β-strand 12 residues would disrupt correct enzyme-DNA alignment and alter pol η's activity and fidelity...
October 2013: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/23830898/hypothesis-driven-single-nucleotide-polymorphism-search-hydn-snp-s
#11
Rebecca J Swett, Angela Elias, Jeffrey A Miller, Gregory E Dyson, G Andrés Cisneros
The advent of complete-genome genotyping across phenotype cohorts has provided a rich source of information for bioinformaticians. However the search for SNPs from this data is generally performed on a study-by-study case without any specific hypothesis of the location for SNPs that are predictive for the phenotype. We have designed a method whereby very large SNP lists (several gigabytes in size), combining several genotyping studies at once, can be sorted and traced back to their ultimate consequence in protein structure...
September 2013: DNA Repair
https://www.readbyqxmd.com/read/23723739/virions-at-the-gates-receptors-and-the-host-virus-arms-race
#12
John M Coffin
All viruses need to bind to specific receptor molecules on the surface of target cells to initiate infection. Virus-receptor binding is highly specific, and this specificity determines both the species and the cell type that can be infected by a given virus. In some well-studied cases, the virus-binding region on the receptor has been found to be unrelated to the receptor's normal cellular function. Resistance to virus infection can thus evolve by selection of mutations that alter amino acids in the binding region with minimal effect on normal function...
May 2013: PLoS Biology
https://www.readbyqxmd.com/read/23486690/comparative-study-of-idh1-mutations-in-gliomas-by-immunohistochemistry-and-dna-sequencing
#13
COMPARATIVE STUDY
Shipra Agarwal, Mehar Chand Sharma, Prerana Jha, Pankaj Pathak, Vaishali Suri, Chitra Sarkar, Kunzang Chosdol, Ashish Suri, Shashank Sharad Kale, Ashok Kumar Mahapatra, Pankaj Jha
BACKGROUND: Mutations involving isocitrate dehydrogenase 1 (IDH 1) occur in a high proportion of diffuse gliomas, with implications on diagnosis and prognosis. About 90% involve exon 4 at codon 132, replacing amino acid arginine with histidine (R132H). Rarer ones include R132C, R132S, R132G, R132L, R132V, and R132P. Most authors have used DNA-based methods to assess IDH1 status. Preliminary studies comparing imunohistochemistry (IHC) with IDH1-R132H mutation-specific antibodies have shown concordance with DNA sequencing and no cross-reactivity with wild-type IDH1 or other mutant proteins...
June 2013: Neuro-oncology
https://www.readbyqxmd.com/read/23096090/amerindians-show-no-association-of-ppar-%C3%AE-2-gene-ala12-allele-and-obesity-an-unthrifty-variant-population-genetics
#14
Antonio Arnaiz-Villena, Mercedes Fernández-Honrado, Cristina Areces, Mercedes Enríquez-de-Salamanca, Sedeka Abd-El-Fatah-Khalil, Carmen Coca, Ignacio Arribas, Manuel Algora, Diego Rey
Obesity is for many scholars the most important starting status that gives rise to Metabolic Syndrome (MS) and Type 2 Diabetes (T2D). In the present paper, a genetically homogeneous Amerindian population, as defined by HLA genes, has been genotyped for one of the MS and T2D predisposing genes: PPAR-γ Ala12 and Pro 12 variants. Ala12 has been negatively associated with obesity, but other authors do not find such an association. Notwithstanding, a meta-analysis that used many subjects clearly demonstrated that PPAR-γ Ala12 bearing ones had a reduced risk for T2D...
February 2013: Molecular Biology Reports
https://www.readbyqxmd.com/read/22972628/kras-p-g13d-mutation-and-codon-12-mutations-are-not-created-equal-in-predicting-clinical-outcomes-of-cetuximab-in-metastatic-colorectal-cancer-a-systematic-review-and-meta-analysis
#15
REVIEW
Chen Mao, Ya-Fang Huang, Zu-Yao Yang, Da-Yong Zheng, Jin-Zhang Chen, Jin-Ling Tang
BACKGROUND: The authors conducted a systematic review and meta-analysis to examine whether patients who had metastatic colorectal cancer (mCRC) with the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) p.G13D mutation (an amino acid substitution at position 13 in KRAS from a glycine to an aspartic acid) and received cetuximab treatment had better clinical outcomes than patients who had mCRC tumors with KRAS codon 12 mutations. METHODS: Relevant studies were identified by a search of MEDLINE, EMBASE, the Chinese Biomedical Database, and Wan Fang Digital Journals from inception to October 2011...
February 15, 2013: Cancer
https://www.readbyqxmd.com/read/22930283/braf-mutation-is-associated-with-early-stage-disease-and-improved-outcome-in-patients-with-low-grade-serous-ovarian-cancer
#16
Rachel N Grisham, Gopa Iyer, Karuna Garg, Deborah DeLair, David M Hyman, Qin Zhou, Alexia Iasonos, Michael F Berger, Fanny Dao, David R Spriggs, Douglas A Levine, Carol Aghajanian, David B Solit
BACKGROUND: Low-grade serous (LGS) ovarian cancer is a chemoresistant disease that accounts for 10% of serous ovarian cancers. Prior studies have reported that 28% to 35% of serous borderline (SB)/LGS ovarian tumors harbor a BRAF mutation, suggesting that BRAF inhibitors may be a rational therapeutic approach for this disease. In the current study, the authors sought to determine whether BRAF or KRAS mutation status was associated with disease stage and/or histology in patients with SB and LGS ovarian cancer...
February 1, 2013: Cancer
https://www.readbyqxmd.com/read/22908207/hemochromatosis-gene-hfe-polymorphisms-and-risk-of-type-2-diabetes-mellitus-a-meta-analysis
#17
Ying Rong, Wei Bao, Shuang Rong, Min Fang, Di Wang, Ping Yao, Frank B Hu, Liegang Liu
The hemochromatosis gene (HFE) has been involved in the etiology of type 2 diabetes mellitus and investigated in numerous epidemiologic studies. The current meta-analysis was conducted to evaluate the gene-disease association in relevant studies. Electronic literature search was performed on June 18, 2011, from databases of PubMed/MEDLINE, EMBASE, and HuGE Navigator. Articles were inspected by 2 authors independently, and data were extracted by identical extraction form. A total of 5,528 type 2 diabetes cases and 6,920 controls in relation to HFE polymorphisms (a cysteine to tyrosine substitution at amino acid position 282 (C282Y) and a histidine to aspartate substitution at amino acid position 63 (H63D)) were included in the meta-analysis (1997-2011)...
September 15, 2012: American Journal of Epidemiology
https://www.readbyqxmd.com/read/22889436/differential-regulation-of-arylalkylamine-n-acetyltransferase-activity-in-chicken-retinal-ganglion-cells-by-light-and-circadian-clock
#18
Diego J Valdez, Eduardo Garbarino-Pico, Nicolás M Díaz, David C Silvestre, Mario E Guido
Retinal ganglion cells (RGCs) contain circadian clocks driving melatonin synthesis during the day, a subset of these cells acting as nonvisual photoreceptors sending photic information to the brain. In this work, the authors investigated the temporal and light regulation of arylalkylamine N-acetyltransferase (AA-NAT) activity, a key enzyme in melatonin synthesis. The authors first examined this activity in RGCs of wild-type chickens and compared it to that in photoreceptor cells (PRs) from animals maintained for 48 h in constant dark (DD), light (LL), or regular 12-h:12-h light-dark (LD) cycle...
October 2012: Chronobiology International
https://www.readbyqxmd.com/read/22882555/osarg-encodes-an-arginase-that-plays-critical-roles-in-panicle-development-and-grain-production-in-rice
#19
Xuefeng Ma, Zhijun Cheng, Ruizhen Qin, Yang Qiu, Yueqin Heng, Hui Yang, Yulong Ren, Xiaole Wang, Jingcui Bi, Xiaoding Ma, Xin Zhang, Jiulin Wang, Cailin Lei, Xiuping Guo, Jie Wang, Fuqing Wu, Ling Jiang, Haiyang Wang, Jianmin Wan
Nitrogen is a crucial nutrient for plant growth and development. Arginine is considered an important amino acid for nitrogen transport and storage, playing a crucial role during plant seedling development. However, little is known about the role of arginine in nitrogen remobilization at the reproductive stage. We isolated a rice mutant with reduced plant height, small panicle and grain size, and low seed-setting rate (10% in nglf-1 compared to 93% in wild-type). Map-based cloning revealed that the mutant was caused by the loss of function of a gene (OsARG) encoding an arginine hydrolysis enzyme, which is consistent with arginine accumulation in the mutant...
August 9, 2012: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/22408688/effect-of-computational-methodology-on-the-conformational-dynamics-of-the-protein-photosensor-lov1-from-chlamydomonas-reinhardtii
#20
Emanuel Peter, Bernhard Dick, Stephan A Baeurle
UNLABELLED: LOV domains are the light-sensitive protein domains of plant phototropins and bacteria. They photochemically form a covalent bond between a flavin mononucleotide (FMN) chromophore and a cysteine, attached to the apo-protein, upon irradiation with blue light, which triggers a signal in the adjacent kinase. Although their signaling state has been well characterized through experimental means, their signal transduction pathway as well as dark-state activity are generally only poorly understood...
October 2011: Journal of Chemical Biology
keyword
keyword
98490
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"