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https://www.readbyqxmd.com/read/28538077/monobloc-frontofacial-or-le-fort-iii-distraction-osteogenesis-in-syndromic-craniosynostosis-three-dimensional-evaluation-of-treatment-outcome-and-the-need-for-central-distraction
#1
Ching-Hsuan Hu, Chieh-Tsai Wu, Ellen Wen-Ching Ko, Philip Kuo-Ting Chen
BACKGROUND: The objectives of this study were to investigate the treatment effect, morphology, and volumetric outcomes of monobloc frontofacial or Le Fort III distraction osteogenesis in syndromic craniosynostosis by 3-dimensional evaluation. MATERIALS AND METHODS: Nine consecutive patients underwent monobloc frontofacial or Le Fort III distraction during 2003 to 2012 were included and evaluated. The patient's evaluation is a minimum of a 4-year follow-up. Pretreatment, post-treatment advancement, and relapse were quantified...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28534531/unravelling-the-biology-of-sclc-implications-for-therapy
#2
REVIEW
Joshua K Sabari, Benjamin H Lok, James H Laird, John T Poirier, Charles M Rudin
Small-cell lung cancer (SCLC) is an aggressive malignancy associated with a poor prognosis. First-line treatment has remained unchanged for decades, and a paucity of effective treatment options exists for recurrent disease. Nonetheless, advances in our understanding of SCLC biology have led to the development of novel experimental therapies. Poly [ADP-ribose] polymerase (PARP) inhibitors have shown promise in preclinical models, and are under clinical investigation in combination with cytotoxic therapies and inhibitors of cell-cycle checkpoints...
May 23, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28534234/functional-outcome-of-patients-with-prolonged-hypoglycemic-encephalopathy
#3
Guillaume Barbara, Bruno Mégarbane, Laurent Argaud, Guillaume Louis, Nicolas Lerolle, Francis Schneider, Stéphane Gaudry, Nicolas Barbarot, Angéline Jamet, Hervé Outin, Sébastien Gibot, Pierre-Edouard Bollaert
BACKGROUND: Little is known about the causes, clinical course and long-term outcome of comatose patients with prolonged hypoglycemic encephalopathy. METHODS: In a multicenter retrospective study conducted in patients hospitalized from July 1, 2004, to July 1, 2014, we investigated functional long-term prognosis and identified prognosis factors of patients admitted in an intensive care unit (ICU) with prolonged neurological manifestations related to hypoglycemia...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28533223/monarch-1-a-phase-2-study-of-abemaciclib-a-cdk4-and-cdk6-inhibitor-as-a-single-agent-in-patients-with-refractory-hr-her2-metastatic-breast-cancer
#4
Maura N Dickler, Sara Tolaney, Hope S Rugo, Javier Cortés, Veronique Dieras, Debra A Patt, Hans Wildiers, Clifford A Hudis, Joyce A O'Shaughnessy, Esther Zamora, Denise Yardley, Martin Frenzel, Andrew G Koustenis, José Baselga
<br />The phase 2 MONARCH 1 study was designed to evaluate the single-agent activity and adverse event (AE) profile of abemaciclib, a selective inhibitor of CDK4 and CDK6, in women with refractory hormone receptor positive (HR+), HER2- metastatic breast cancer (MBC). <br /><br />Experimental Design: <br />MONARCH 1 was a phase 2 single arm open-label study. Women with HR+/HER2- MBC who had progressed on or after prior endocrine therapy and had 1 or 2 chemotherapy regimens in the metastatic setting were eligible...
May 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28532575/readmission-rates-after-transcatheter-aortic-valve-replacement-in-high-and-extreme-risk-patients-with-severe-aortic-stenosis
#5
Jessica Forcillo, Jose F Condado, Jose N Binongo, Yi Lasanajak, Hope Caughron, Vasilis Babaliaros, Chandan Devireddy, Bradley Leshnower, Robert A Guyton, Peter C Block, Amy Simone, Patricia Keegan, Paul Khairy, Vinod H Thourani
OBJECTIVE: In high- or extreme-risk patients undergoing transcatheter aortic valve replacement, readmissions have not been adequately studied and are the subject of increased scrutiny by healthcare systems. The objectives of this study were to determine the incidence of 30-day and 1-year cardiac and noncardiac readmissions, identify predictors of readmission, and assess the association between readmission and 1-year mortality. METHODS: A retrospective review was performed on 714 patients who underwent transcatheter aortic valve replacement from September 2007 to January 2015 at Emory University...
April 18, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28532002/electrochemical-sensor-for-detection-of-hydrogen-peroxide-modified-with-prussian-blue-electrodeposition-on-nitrogen-phosphorus-and-sulfur-co-doped-porous-carbons-chitosan
#6
Xiurong Zhai, Yonghong Li, Jisen Li, Chengyang Yue, Xiaowu Lei
Nitrogen, phosphorus and sulfur co-doped porous carbons (N, P, S@PC) were well dispersed in the chitosan (CS) acid solution, in particular via covalently interaction, which could avoid the aggregation of N, P, S@PC in most solvents. Moreover, CS could also avoid N, P, S@PC leakage from the modified electrode. A novel electrochemical sensor was then developed through prussian blue (PB) was electrodeposited on the glass carbon (GC) electrode modified with N, P, S@PC-CS composite. Results with scanning electron microscopy image, illustrate that PB/N, P, S@PC-CS composite distributes very uniformly on the substrate surface, which is hoped to be very attractive for determination of hydrogen peroxide (H2O2)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530424/the-collection-of-historical-instruments-at-national-taiwan-university
#7
Lothar Spillmann, Su-Ling Yeh, Chien-Chung Chen, Keng-Cheng Liang, Shojiro Sakurai
This article presents three of the historical instruments from the National Taiwan University collection. The instruments were built between 1894 and 1902. The instruments are (1) Meumann's Largest Time Sense Apparatus, (2) Wundt's Pendulum Tachistoscope, and (3) Schumann's Wheel Tachistoscope. It is hoped that the presentation of these three historical instruments will serve a triple purpose: (a) to enable a greater appreciation of achievements of the scientists on whose shoulders we stand; (b) to illustrate the need for the time-consuming task of designing specialized apparatuses for a given experiment, typical at the time; and (c) to encourage a reflection on the mutual relationship between the instruments available, the questions asked, and the experiments done...
May 2017: History of Psychology
https://www.readbyqxmd.com/read/28528986/how-family-members-of-mentally-ill-offenders-experience-the-internment-measure-and-forensic-psychiatric-treatment-in-belgium-a-qualitative-study
#8
Sara Rowaert, Stijn Vandevelde, Gilbert Lemmens, Kurt Audenaert
Mentally ill offenders in Belgium can be subjected to mandated care under an "internment measure" if they are viewed as a danger to society. This study investigated how family members of mentally ill offenders experience this internment measure and view the (forensic) psychiatric treatment of their relative. Semi-structured interviews were conducted with 24 relatives and analysed using Nvivo 11. Six different themes emerged: (1) the criminal offence and the internment measure as an additional stigma, (2) ambivalent feelings towards the judicial system, (3) prison is not the right place to be, (4) mental health support as an answer to problems, (5) fight a losing battle, and (6) while there is life there is hope...
May 18, 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/28516244/a-comparison-of-basilar-artery-diameters-measured-by-t2wi-and-tof-mr-angiography
#9
Emre Can Çelebioğlu, Muhammed Mustafa Aldur, Selcuk Tunali, Murvet Hayran, Ayşe Beliz Taşçıoğlu, F Mustafa Sargon
PURPOSE: The purpose of our study is to compare basilar artery diameters (BAD) measured by T2WI to diameters measured by TOF MR angiography (MRA). By doing this, we hope to understand how compatible these two methodologies are with each other. METHODS: We used data from 100 patients (59 females, 41 males) who underwent a session of both T2W MRI and TOF MRA at the same time (ages between 18 and 83). We measured BAD by both T2WI and TOF MRA in three different levels...
May 17, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28510600/complete-comparison-display-ccd-evaluation-of-ethanol-extracts-of-centella-asiatica-and-withania-somnifera-shows-that-they-can-non-synergistically-ameliorate-biochemical-and-behavioural-damages-in-mptp-induced-parkinson-s-model-of-mice
#10
Maheep Bhatnagar, Ishan Goel, Tathagato Roy, Sunil Dutt Shukla, Sukant Khurana
Parkinson's disease remains as one of the most common debilitating neurodegenerative disorders. With the hopes of finding agents that can cure or reduce the pace of progression of the disease, we studied two traditional medicinal plants: Centella asiatica and Withania somnifera that have been explored in some recent studies. In agreement with the previous work on ethanol extracts of these two plants in mice model, we saw an improvement in oxidative stress profile as well as behavioral performance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson-like symptoms in Balb/c mice...
2017: PloS One
https://www.readbyqxmd.com/read/28510120/obscurin-variants-and-inherited-cardiomyopathies
#11
REVIEW
Steven Marston
The inherited cardiomyopathies, hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and left ventricular non-compaction (LVNC), have been frequently associated with mutations in sarcomeric proteins. In recent years, advances in DNA sequencing technology has allowed the study of the giant proteins of the sarcomere, such as titin and nebulin. Obscurin has been somewhat neglected in these studies, largely because its functional role is far from clear, although there was an isolated report in 2007 of obscurin mutations associated with HCM...
May 5, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28505998/-i-really-hope-it-comes-back-olfactory-impairment-following-traumatic-brain-injury-a-longitudinal-study
#12
Melanie Drummond, Jacinta Douglas, John Olver
BACKGROUND: Olfactory Impairment (OI) can present in up to 66% of all individuals following traumatic brain injury (TBI) and can have significant implications for everyday life. OBJECTIVE: To investigate the predictive factors, natural progression and consequences of OI in following TBI in individuals 12 months post injury. METHODS: In this prospective longitudinal study, 37 adults (28 males, 9 females), mean age 42.3 years (SD 19.4), with predominately severe TBI (mean length of posttraumatic amnesia (PTA) 28...
May 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28505697/-the-development-of-palliative-care-hospital-support-teams-hpcts-in-bavaria-from-2011-2015-tasks-acceptance-structure-and-funding
#13
Johanna Anneser, Tamara Thurn, Gian Domenico Borasio
Introduction Palliative care hospital support teams (HPCTs) provide inpatients from all departments palliative medical support. Seriously ill as well as dying patients, who are being treated in facilities that do not have their own palliative care unit, can benefit from these multi-professional teams just as much as patients who do not (yet) need to be admitted to a palliative care unit. At the end of 2015, 53 HPCTs, which were in accordance with the requirements established in the "Program for HPCTs" by the Bavarian Ministry of Health in 2009, had been approved in Bavaria...
May 15, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28505118/communicatively-constructing-the-bright-and-dark-sides-of-hope-family-caregivers-experiences-during-end-of-life-cancer-care
#14
Jody Koenig Kellas, Katherine M Castle, Alexis Johnson, Marlene Z Cohen
(1) Background: The communication of hope is complicated, particularly for family caregivers in the context of cancer who struggle to maintain hope for themselves and their loved ones in the face of terminality. In order to understand these complexities, the current study examines the bright and dark sides of how hope is communicated across the cancer journey from the vantage point of bereaved family caregivers; (2) Methods: We analyzed interviews with bereaved family caregivers using qualitative thematic and case oriented strategies to identify patterns in the positive and negative lived experiences when communicating about hope at the end of life; (3) Results: Two overarching patterns of hope emerged...
May 15, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/28504866/a-short-report-on-current-fertility-preservation-strategies-for-boys
#15
Wei Li Cindy Ho, Harold Bourne, Debra Gook, Gary Clarke, Matthew Kemertzis, Kate Stern, Franca Agresta, Yves Heloury, Hannah Clarke, Lisa Orme, Michael Sullivan, Yasmin Jayasinghe, Margaret R Zacharin
BACKGROUND: Advances in cancer treatment have led to improved long term survival after childhood cancer, but often at a price of impaired future fertility. Fertility Preservation (FP) in male children and early adolescents poses unique challenges as efficacy is unproven. OBJECTIVES: To describe characteristics of testicular tissue cryopreservation (TTCP) specimens taken from paediatric and adolescent patients, stratified by age, and prior chemotherapy, if any, and to demonstrate evidence for germ cells MATERIALS AND METHODS: Retrospective review of gonadal biopsies and clinical records of patients consented into the Royal Children's Hospital FP program between 1987-2015...
May 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28503722/fertility-preservation-with-ovarian-stimulation-and-time-to-treatment-in-women-with-stage-ii-iii-breast-cancer-receiving-neoadjuvant-therapy
#16
A Jo Chien, Julia Chambers, Fiona Mcauley, Tessa Kaplan, Joseph Letourneau, Jimmy Hwang, Mi-Ok Kim, Michelle E Melisko, Hope S Rugo, Laura J Esserman, Mitchell P Rosen
PURPOSE: To determine whether fertility preservation with ovarian stimulation (OS) results in treatment delay in breast cancer (BC) patients receiving neoadjuvant therapy (NAT). METHODS: This is a retrospective study of women screened for the prospective neoadjuvant ISPY2 trial at the University of California San Francisco. All patients were <43, had stage II-III BC, and received neoadjuvant therapy. Time to initiation of NAT was compared between women who underwent OS (STIM) and women who did not (control)...
May 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28500566/an-update-on-addressing-important-peripheral-nerve-problems-challenges-and-potential-solutions
#17
Wilson Z Ray, Mark A Mahan, Danzhu Guo, Danqing Guo, Michel Kliot
From time to time it is thoughtful and productive to review a medical field and reflect upon what are the major issues that need to be addressed and what is being done to do so. This review article is not meant to be all-inclusive but rather focuses on four evolving areas in the field of peripheral nerve disorders and treatments: (1) nerve surgery under ultrasound guidance using a new ultra-minimally invasive thread technique; (2) evolving magnetic resonance imaging (MRI) and ultrasound imaging techniques that are helping to both diagnose and treat a variety of peripheral nerve problems including entrapment neuropathies, traumatic nerve injuries, and masses arising from nerves; (3) promoting recovery after nerve injury using electrical stimulation; and (4) developing animal models to reproduce a severe nerve injury (neurotmetic grade in continuity) that requires a surgical intervention and repair...
May 12, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28500015/social-synchrony-on-complex-networks
#18
Qi Xuan, Zhi-Yuan Zhang, Chenbo Fu, Hong-Xiang Hu, Vladimir Filkov
Social synchrony (SS) is an emergent phenomenon in human society. People often mimic others which, over time, can result in large groups behaving similarly. Drawing from prior empirical studies of SS in online communities, here we propose a discrete network model of SS based on four attributes: 1) depth of action; 2) breadth of impact, i.e., a large number of actions are performed with a large group of people involved; 3) heterogeneity of role, i.e., people of higher degree play more important roles; and 4) lastly, emergence of phenomenon, i...
May 9, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28498658/discovery-of-clinical-candidate-1-2s-3s-4s-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl-methoxy-7-methoxyisoquinoline-6-carboxamide-pf-06650833-a-potent-selective-inhibitor-of-interleukin-1-receptor-associated-kinase-4-irak4-by-fragment-based-drug-design
#19
Katherine L Lee, Catherine M Ambler, David R Anderson, Brian P Boscoe, Andrea G Bree, Joanne I Brodfuehrer, Jeanne S Chang, Chulho Choi, Seung Won Chung, Kevin J Curran, Jacqueline E Day, Christoph M Dehnhardt, Ken Dower, Susan E Drozda, Richard K Frisbie, Lori Krim Gavrin, Joel A Goldberg, Seungil Han, Martin Hegen, David Hepworth, Heidi R Hope, Satwik Kamtekar, Iain C Kilty, Arthur Lee, Lih-Ling Lin, Frank E Lovering, Michael D Lowe, John P Mathias, Heidi M Morgan, Elizabeth A Murphy, Nikolaos Papaioannou, Akshay Patny, Betsy S Pierce, Vikram R Rao, Eddine Saiah, Ivan J Samardjiev, Brian M Samas, Marina W H Shen, Julia H Shin, Holly H Soutter, Joseph W Strohbach, Peter T Symanowicz, Jennifer R Thomason, John D Trzupek, Richard Vargas, Fabien Vincent, Jiangli Yan, Christoph W Zapf, Stephen W Wright
Through fragment-based drug design focused on engaging the active site of IRAK4 and leveraging three-dimensional topology in a ligand-efficient manner, a micromolar hit identified from a screen of a Pfizer fragment library was optimized to afford IRAK4 inhibitors with nanomolar potency in cellular assays. The medicinal chemistry effort featured the judicious placement of lipophilicity, informed by co-crystal structures with IRAK4 and optimization of ADME properties to deliver clinical candidate PF-06650833 (compound 40)...
May 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28498576/a-critique-of-the-ultra-high-risk-and-transition-paradigm
#20
Jim van Os, Sinan Guloksuz
The transdiagnostic expression of psychotic experiences in common mental disorder (anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a small minority of people may indeed develop a clinical picture that meets criteria for schizophrenia. However, it appears neither useful nor valid to observe early states of multidimensional psychopathology in young people through the "schizo"-prism, and apply misleadingly simple, unnecessary and inefficient binary concepts of "risk" and "transition"...
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
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