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https://www.readbyqxmd.com/read/29351711/-beck-anxiety-inventory-german-version-a-reliable-valid-patientfriendly-instrument-for-measuring-clinical-anxiety
#1
Edgar Geissner, Anne Huetteroth
The Beck Anxiety Inventory (BAI) is available in German. Apart from data in its manual, there are no further reports on the psychometric properties of this questionnaire and on its suitability for clinical use in Germany. This study therefore offers an independent investigation into the psychometrics as well as the clinical characteristics of the BAI. Three samples with n=145, n=90, and n=174 comprised inpatients diagnosed with anxiety disorders and treated in a large psychosomatic hospital. In addition to the BAI, the clinician rating Hamilton Anxiety Scale (HamA), the State-Trait-Anxiety Inventory (STAI) as well as the two anxiety subscales of the Symptom Checklist 90 (SCL 90) were used to establish convergent validity...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29350138/increase-in-ocular-syphilis-cases-at-ophthalmologic-reference-center-france-2012-2015
#2
Ana Catarina Pratas, Pablo Goldschmidt, David Lebeaux, Claire Aguilar, Natalia Ermak, Jonathan Benesty, Caroline Charlier, Edgar Benveniste, Lilia Merabet, Neila Sedira, Emilie Hope-Rapp, Christine Chaumeil, Bahram Bodaghi, Emmanuel Héron, José-Alain Sahel, Olivier Lortholary, Marie-Hélène Errera
We describe the frequency, demographic and clinical features, and visual outcomes of ocular syphilis infections observed during 2012-2015 at a tertiary reference center in Paris, France. Twenty-one cases (29 eyes) were identified. The occurrence of ocular syphilis increased from 1 case in 2012 to 5 cases in 2013, 6 cases in 2014, and 9 cases in 2015 (2.22-25.21/1,000 individual patients/year for the period). Among case-patients, an annual 20%-33% were co-infected with HIV. Seventy-six percent of ocular syphilis infections occurred in men who have sex with men...
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29349777/in-bed-cycling-in-the-icu-patient-safety-and-recollections-with-motivational-effects
#3
M Ringdal, M Warren Stomberg, K Egnell, E Wennberg, R Zätterman, C Rylander
BACKGROUND: In-bed cycling (IBC) is gaining interest for implementation in intensive care units. Our main objective was to explore patient recollections and experiences of early mobilization, including IBC. Secondly, we aimed to examine if IBC was safe and feasible. METHODS: Eleven participants were interviewed about their experiences during their critical illnesses and active mobilization in the intensive care unit. The interviews were analyzed thematically. Six participants were also monitored for physiological reactions and adverse events during IBC while mechanically ventilated...
January 18, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29349509/complex-issues-in-new-ultrasound-guided-nerve-blocks-how-to-name-where-to-inject-and-how-to-publish
#4
Masanori Yamauchi, Yutaka Sato
The recent development of ultrasound-guide nerve block has led to innovation in anesthesia and pain clinics. However, it has also led to some complex issues, including (1) how to name a new technique, (2) the appropriateness of an intramuscular approach, and (3) how to publicize a new technique. This review addresses naming strategy, feasibility of intramuscular approach block, and methods of publication. First, researchers and authors should pay attention to appropriate nomenclature for the term 'approach', 'compartment block', and 'nerve block' for a new block...
January 18, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29348495/preclinical-evaluation-of-antitumor-activity-of-the-proteasome-inhibitor-mln2238-ixazomib-in-hepatocellular-carcinoma-cells
#5
Giuseppa Augello, Martina Modica, Antonina Azzolina, Roberto Puleio, Giovanni Cassata, Maria Rita Emma, Caterina Di Sano, Antonella Cusimano, Giuseppe Montalto, Melchiorre Cervello
Hepatocellular carcinoma (HCC) is one of the common malignancies and is an increasingly important cause of cancer death worldwide. Surgery, chemotherapy, and radiation therapy extend the 5-year survival limit in HCC patients by only 6%. Therefore, there is a need to develop new therapeutic approaches for the treatment of this disease. The orally bioavailable proteasome inhibitor MLN2238 (ixazomib) has been demonstrated to have anticancer activity. In the present study, we investigated the preclinical therapeutic efficacy of MLN2238 in HCC cells through in vitro and in vivo models, and examined its molecular mechanisms of action...
January 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29348004/predictors-and-clinical-outcomes-of-next-day-discharge-after-minimalist-transfemoral-transcatheter-aortic-valve%C3%A2-replacement
#6
Norihiko Kamioka, John Wells, Patricia Keegan, Stamatios Lerakis, Jose Binongo, Frank Corrigan, Jose Condado, Ateet Patel, Jessica Forcillo, Leslie Ogburn, Andy Dong, Hope Caughron, Amy Simone, Bradley Leshnower, Chandan Devireddy, Kreton Mavromatis, Robert Guyton, James Stewart, Vinod Thourani, Peter C Block, Vasilis Babaliaros
OBJECTIVES: This study sought to investigate predictors and safety of next-day discharge (NDD) after transcatheter aortic valve replacement (TAVR). BACKGROUND: Information about predictors and safety of NDD after TAVR is limited. METHODS: The study reviewed 663 consecutive patients who underwent elective balloon-expandable TAVR (from July 2014 to July 2016) at our institution. We first determined predictors of NDD in patients who underwent minimalist transfemoral TAVR...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29346209/the-society-of-thoracic-surgeons-the-society-of-cardiovascular-anesthesiologists-and-the-american-society-of-extracorporeal-technology-clinical-practice-guidelines-anticoagulation-during-cardiopulmonary-bypass
#7
Linda Shore-Lesserson, Robert A Baker, Victor A Ferraris, Philip E Greilich, David Fitzgerald, Philip Roman, John W Hammon
Despite more than a half century of "safe" cardiopulmonary bypass (CPB), the evidence base surrounding the conduct of anticoagulation therapy for CPB has not been organized into a succinct guideline. For this and other reasons, there is enormous practice variability relating to the use and dosing of heparin, monitoring heparin anticoagulation, reversal of anticoagulation, and the use of alternative anticoagulants. To address this and other gaps, The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiologists, and the American Society of Extracorporeal Technology developed an Evidence Based Workgroup...
February 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29345801/individual-psychological-therapy-in-an-acute-inpatient-setting-service-user-and-psychologist-perspectives
#8
Catherine Small, Nancy Pistrang, Vyv Huddy, Claire Williams
OBJECTIVES: The acute inpatient setting poses potential challenges to delivering one-to-one psychological therapy; however, there is little research on the experiences of both receiving and delivering therapies in this environment. This qualitative study aimed to explore service users' and psychologists' experiences of undertaking individual therapy in acute inpatient units. It focused on the relationship between service users and psychologists, what service users found helpful or unhelpful, and how psychologists attempted to overcome any challenges in delivering therapy...
January 18, 2018: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/29344809/regeneration-of-functional-alveoli-by-adult-human-sox9-airway-basal-cell-transplantation
#9
Qiwang Ma, Yu Ma, Xiaotian Dai, Tao Ren, Yingjie Fu, Wenbin Liu, Yufei Han, Yingchuan Wu, Yu Cheng, Ting Zhang, Wei Zuo
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying lung stem/progenitor cells with regenerative capacity and utilizing them to reconstruct functional tissue is one of the biggest hopes to reverse the damage and cure such diseases. Here we showed that a rare population of SOX9+ basal cells (BCs) located at airway epithelium rugae can regenerate adult human lung. Human SOX9+ BCs can be readily isolated by bronchoscopic brushing and indefinitely expanded in feeder-free condition...
January 17, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29344777/giant-cell-arteritis-practical-pearls-and-updates
#10
REVIEW
Swati Pradeep, Jonathan H Smith
PURPOSE OF REVIEW: The purpose of this review is to summarize recent updates and distill practical points from the literature which can be applied to the care of patients with suspected and confirmed giant cell arteritis (GCA). RECENT FINDINGS: Contemporary thinking implicates a fundamental failure of T regulatory cell function in GCA pathophysiology, representing opportunity for novel therapeutic avenues. Tocilizumab has become the first Food and Drug Administration-approved treatment for GCA following demonstration of efficacy and safety in a phase 3 clinical trial...
January 17, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29341210/subchorionic-hematoma-correlation-of-grading-techniques-with-first-trimester-pregnancy-outcome
#11
Howard T Heller, Elizabeth A Asch, Sara M Durfee, Robin P Goldenson, Hope E Peters, Elizabeth S Ginsburg, Peter M Doubilet, Carol B Benson
OBJECTIVES: To evaluate and compare grading systems of subchorionic hematoma (SCH) on first-trimester ultrasound examinations with live embryos to assess which best correlates with early pregnancy outcome and to assess the effect of gestational age at the time of diagnosis on outcome. METHODS: First-trimester live singleton pregnancies between 6 and 11 weeks' gestational age with SCH were identified by an institutional database search. First-trimester outcome was categorized as "live" or "demise" based on ultrasound or medical record documentation...
January 17, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29339307/anticoccidial-activity-of-fruit-peel-of-punica-granatum-l
#12
Shazia Ahad, Syed Tanveer, Tauseef Ahmad Malik, Irshad Ahmad Nawchoo
In the interests of food safety and public health, plants and their compounds are now re-emerging as an alternative approach to treat parasitic diseases. Here, we studied the anticoccidial effect of different solvent extracts of the fruit peel of Punica granatum-a commercial waste from pomegranate juice industries. The hope underlying these experiments was to find a sustainable natural product for controlling coccidiosis. The plant extracts were prepared using solvents of different polarity. Acute oral toxicity study was first carried out to see the safety of crude extracts...
January 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29337132/understanding-pivotal-experiences-in-behavior-change-for-the-design-of-technologies-for-personal-wellbeing
#13
Arpita Bhattacharya, Samantha Kolovson, Yi-Chen Sung, Mike Eacker, Michael Chen, Sean A Munson, Julie A Kientz
Most health technologies are designed to support people who have already decided to work toward better health. Thus, there remains an opportunity to design technologies to help motivate people who have not yet decided to make a change. Understanding the experiences of people who have already started to make a health behavior change and how they made a pivotal decision can be useful in understanding how to design such tools. In this paper, we describe results from data collected in 2 phases. Phase 1 consisted of 127 surveys and 13 interviews with adults who have already accomplished behavior change(s)...
January 11, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29334910/treatment-selection-of-early-stage-non-small-cell-lung-cancer-the-role-of-the-patient-in-clinical-decision-making
#14
S Mokhles, J J M E Nuyttens, M de Mol, J G J V Aerts, A P W M Maat, Ö Birim, A J J C Bogers, J J M Takkenberg
BACKGROUND: The objective of this study is to investigate the role and experience of early stage non-small cell lung cancer (NSCLC) patient in decision making process concerning treatment selection in the current clinical practice. METHODS: Stage I-II NSCLC patients (surgery 55 patients, SBRT 29 patients, median age 68) were included in this prospective study and completed a questionnaire that explored: (1) perceived patient knowledge of the advantages and disadvantages of the treatment options, (2) experience with current clinical decision making, and (3) the information that the patient reported to have received from their treating physician...
January 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29334811/the-experiences-of-physical-rehabilitation-in-individuals-with-spinal-cord-injuries-a-qualitative-thematic-synthesis
#15
Janelle Unger, Hardeep Singh, Avril Mansfield, Sander L Hitzig, Erica Lenton, Kristin E Musselman
PURPOSE: The purpose of this thematic synthesis review was to identify and synthesise published qualitative research on the perspectives of individuals with spinal cord injuries with respect to physical rehabilitation interventions. MATERIALS AND METHODS: The peer-reviewed literature was searched across seven databases and identified abstracts were independently screened by two reviewers. A thematic synthesis methodology was used to code and synthesise the results from the included studies...
January 15, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29334553/post-treatment-controllers-after-treatment-interruption-in-chronically-hiv-infected-patients
#16
Franco Maggiolo, Elisa Di Filippo, Laura Comi, Annapaola Callegaro
OBJECTIVE: Control HIV replication requires continuous combined antiretroviral therapy (cART) as discontinuation of cART results in a rapid viral rebound. However, a few individuals exist who took cART for several years and did not show the expected viral rebound after treatment cessation. Most post-treatment controllers (PTCs) are early treated individuals. We report three cases who started cART during chronic infection. DESIGN: Patients were treated and monitored according to Italian guidelines...
January 13, 2018: AIDS
https://www.readbyqxmd.com/read/29331079/lmod3-associated-nemaline-myopathy-prenatal-ultrasonographic-pathologic-and-molecular-findings
#17
Michal Berkenstadt, Ben Pode-Shakked, Ortal Barel, Hila Barash, Reuven Achiron, Yinon Gilboa, Dvora Kidron, Annick Raas-Rothschild
To describe the prenatal presentation, including ultrasonographic, histologic, and molecular findings, in 2 fetuses affected with LMOD3-related nemaline myopathy. Prenatal ultrasonographic examinations and histopathologic studies were performed on 2 fetuses with evidence of nemaline myopathy. To establish a molecular diagnosis, whole-exome sequencing was pursued for the affected fetuses. Nemaline myopathy is a common form of congenital myopathy manifesting with nonprogressive generalized muscle weakness, hypotonia, and electron-dense protein inclusions in skeletal myofibers...
January 13, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#18
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29327925/writing-theory-and-modeling-papers-for-langmuir-the-good-the-bad-and-the-ugly
#19
David S Sholl, Zuihof Han, Shu-Hong Yu
Langmuir has a long tradition of publishing excellent theory and modeling papers. As of the time of writing, for example, two modeling papers from 2013 are among the most cited 10 papers in Langmuir from that year [1,2] and the most cited paper from Langmuir in 2016 is a theory and modeling paper [3]. At the same time, many manuscripts using theory and modeling are submitted to Langmuir but are ultimately rejected. Although Langmuir has a mandate to publish the highest quality work of all kinds relevant to interface science, there are some issues that exist that are specific to considering work based on theory and modeling...
January 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29324431/a-descriptive-qualitative-study-to-assess-patient-experiences-following-stoma-reversal-after-rectal-cancer-surgery
#20
Maria Reinwalds, Andrea Blixter, Eva Carlsson
Standard surgical treatment for patients operated for rectal cancer is abdominoperineal excision of the tumor result- ing in a permanent colostomy or an anterior resection, often with construction of a temporary loop ileostomy. Both options impact bowel function. Living with a permanent colostomy has been studied in depth, but knowledge is limited about patients' experiences living with a resected rectum after stoma reversal and how it affects daily life. A qualitative study was conducted to describe the rst 4 to 6 weeks after reversal of a temporary loop ileostomy due to rectal cancer...
December 2017: Ostomy/wound Management
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