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https://www.readbyqxmd.com/read/28446544/cellular-expression-of-pd-l1-in-the-peripheral-blood-of-lung-cancer-patients-is-associated-with-worse-survival
#1
Daniel J Boffa, Ryon P Graf, Michelle C Salazar, Jessica Hoag, David Lu, Rachel Krupa, Jessica Louw, Lyndsey Dugan, Yipeng Wang, Mark Landers, Mahipal Suraneni, Stephanie B Greene, Samir Makani, Marisa Magaña, Lyudmila Bazhenova, Ryan V Dittamore, Jorge Nieva
BACKGROUND: Lung cancer treatment has become increasingly dependent upon invasive biopsies to profile tumors for personalized therapy. Recently, tumor expression of PD-L1 has gained interest as a potential predictor of response to immunotherapy. Circulating biomarkers present an opportunity for tumor profiling without the risks of invasive procedures. We characterized PD-L1 expression within populations of nucleated cells in the peripheral blood of lung cancer patients in hopes of expanding the role of liquid biopsy in this setting...
April 26, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28446244/ketogenic-diet-in-the-treatment-of-epilepsy-in-children-under-the-age-of-2-years-study-protocol-for-a-randomised-controlled-trial
#2
Siobhan Titre-Johnson, Natasha Schoeler, Christin Eltze, Ruth Williams, Katharina Vezyroglou, Helen McCullagh, Nick Freemantle, Simon Heales, Rachel Kneen, Louise Marston, Tim Martland, Irwin Nazareth, Elizabeth Neal, Andrew Lux, Alasdair Parker, Shakti Agrawal, Penny Fallon, J Helen Cross
BACKGROUND: The incidence of epilepsy is greatest in the first 2 years of life, an age group where there is generally a poor prognosis for both seizure control and neurodevelopmental outcome. Early control of seizures can be associated with better developmental outcome but many of the epilepsies presenting in infancy are poorly responsive to antiepileptic medication. The ketogenic diet (KD) is a high-fat, low-carbohydrate diet designed to mimic the effects of starvation on the body. Dietary fat is converted into ketones in the body and used as an energy source by the brain...
April 26, 2017: Trials
https://www.readbyqxmd.com/read/28443532/a-writer-s-guide-to-education-scholarship-quantitative-methodologies-for-medical-education-research-part-1
#3
Brent Thoma, Paola Camorlinga, Teresa M Chan, Andrew Koch Hall, Aleisha Murnaghan, Jonathan Sherbino
BACKGROUND: Quantitative research is one of the many research methods used to help educators advance their understanding of questions in medical education. However, little research has been done on how to succeed in publishing in this area. OBJECTIVE: We conducted a scoping review to identify key recommendations and reporting guidelines for quantitative educational research and scholarship. METHODS: Medline, ERIC, and Google Scholar were searched for English-language articles published between 2006 and January 2016 using the search terms, "research design," "quantitative," "quantitative methods," and "medical education...
April 26, 2017: CJEM
https://www.readbyqxmd.com/read/28442899/approaches-to-drug-therapy-for-copd-in-russia-a-proposed-therapeutic-algorithm
#4
Kirill A Zykov, Svetlana I Ovcharenko
Until recently, there have been few clinical algorithms for the management of patients with COPD. Current evidence-based clinical management guidelines can appear to be complex, and they lack clear step-by-step instructions. For these reasons, we chose to create a simple and practical clinical algorithm for the management of patients with COPD, which would be applicable to real-world clinical practice, and which was based on clinical symptoms and spirometric parameters that would take into account the pathophysiological heterogeneity of COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28441932/an-experimental-comparison-of-web-push-vs-paper-only-survey-procedures-for-conducting-an-in-depth-health-survey-of-military-spouses
#5
Hope Seib McMaster, Cynthia A LeardMann, Steven Speigle, Don A Dillman
BACKGROUND: Previous research has found that a "web-push" approach to data collection, which involves contacting people by mail to request an Internet survey response while withholding a paper response option until later in the contact process, consistently achieves lower response rates than a "paper-only" approach, whereby all respondents are contacted and requested to respond by mail. METHOD: An experiment was designed, as part of the Millennium Cohort Family Study, to compare response rates, sample representativeness, and cost between a web-push and a paper-only approach; each approach comprised 3 stages of mail contacts...
April 26, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28440624/acid-base-catalysis-in-glycosidations-a-nature-derived-alternative-to-the-generally-employed-methodology
#6
Peng Peng, Richard R Schmidt
Inverting glycosyltransferases enforce in the active site an intramolecular, acid-base catalyzed glycosidation that, due to proximity of the donor anomeric carbon and the acceptor hydroxyl group, follows an SN2-type reaction. Spacers, tethering donor and acceptor via nonreacting functional groups, led in intramolecular glycosidations to excellent yields and, independent of the donor anomeric configuration, to either the α- or the β-anomer. The requirement of a demanding protecting group pattern confines the application of this efficient method...
April 25, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28438406/coverage-and-determinants-of-childhood-immunization-in-nigeria-a-systematic-review-and-meta-analysis
#7
REVIEW
Davies Adeloye, Wura Jacobs, Ann O Amuta, Oluwatomisin Ogundipe, Oluwaseun Mosaku, Muktar A Gadanya, Gbolahan Oni
INTRODUCTION: The proportion of fully immunized children in Nigeria is reportedly low. There are concerns over national immunization data quality, with this possibly limiting country-wide response. We reviewed publicly available evidence on routine immunization across Nigeria to estimate national and zonal coverage of childhood immunization and associated determinants. METHODS: A systematic search of Medline, EMBASE, Global Health and African Journals Online (AJOL) was conducted...
April 21, 2017: Vaccine
https://www.readbyqxmd.com/read/28437938/focus-issue-introduction-advanced-solid-state-lasers-assl-2016
#8
Yoonchan Jeong, Christian Kränkel, Almantas Galvanauskas, Kenneth Schepler, Takunori Taira, Shibin Jiang
The editors introduce the focus issue on "Advanced Solid-State Lasers (ASSL) 2016", which is based on the topics presented at a conference of the same name held in Boston, USA, from October 30 to November 3, 2016. This focus issue, jointly prepared by Optics Express and Optical Materials Express, includes 20 contributed papers (14 for Optics Express and 6 for Optical Materials Express) selected from the voluntary submissions from attendees who presented at the conference and have extended their work into complete research articles...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28436287/positive-affect-and-physical-activity-testing-effects-on-goal-setting-activation-prioritisation-and-attainment
#9
David S Cameron, Emma J Bertenshaw, Paschal Sheeran
OBJECTIVE: The present research tested whether incidental positive affect promotes pursuit of physical activity goals. Four key features of goal pursuit were examined - setting physical activity goals (Study 1), goal activation (Study 2), and goal prioritization and goal attainment (Study 3). DESIGN: Participants (Ns = 80, 81, and 59, in Studies 1-3, respectively) were randomized to positive affect (joy, hope) or neutral affect (control) conditions in each study...
April 23, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28432944/phototoxic-action-of-a-zinc-ii-phthalocyanine-encapsulated-into-poloxamine-polymeric-micelles-in-2d-and-3d-colon-carcinoma-cell-cultures
#10
Nicolás Chiarante, María C García Vior, Josefina Awruch, Julieta Marino, Leonor P Roguin
Photodynamic therapy is emerging as a hopeful method for the treatment of oncological diseases. In the search of novel therapeutic strategies for colorectal cancer, in this work we reported the photocytotoxic activity of a lipophilic zinc(II) phthalocyanine on a murine colon adenocarcinoma cell line (CT26 cells). The 2,9(10),16(17),23(24) tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II), named Pc9, was encapsulated into Tetronic® 1107 polymeric poloxamine micelles (T1107) and assayed in 2D and 3D cell cultures...
April 11, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28426839/medical-history-in-the-hellenic-journal-of-nuclear-medicine
#11
EDITORIAL
Andreas Otte, Byeong Cheol Ahn
The Hellenic Journal of Nuclear Medicine is about to celebrate its 20th anniversary end of 2017. On board of the editorial team since 2003, this journal has influenced me like a good friend over the many past years. From time to time, the journal has published interesting and valuable historical notes. They show that nuclear medicine has a history and that medicine is its basis. They also teach us today, and some of the ancient perspectives and approaches are still valid. The reader of HJNM may be interested in these historical contributions, as they are timeless...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28423156/creation-of-an-internal-teledermatology-store-and-forward-system-in-an-existing-electronic-health-record-a-pilot-study-in-a-safety-net-public-health-and-hospital-system
#12
Zachary A Carter, Shauna Goldman, Kristen Anderson, Xiaxiao Li, Linda S Hynan, Benjamin F Chong, Arturo R Dominguez
Importance: External store-and-forward (SAF) teledermatology systems operate separately from the primary health record and have many limitations, including care fragmentation, inadequate communication among clinicians, and privacy and security concerns, among others. Development of internal SAF workflows within existing electronic health records (EHRs) should be the standard for large health care organizations for delivering high-quality dermatologic care, improving access, and capturing other telemedicine benchmark data...
April 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28419412/eliminating-malignant-cells-from-cryopreserved-ovarian-tissue-is-possible-in-leukaemia-patients
#13
Michelle Soares, Pascale Saussoy, Mathilde Maskens, Hélène Reul, Christiani A Amorim, Jacques Donnez, Marie-Madeleine Dolmans
Reimplantation of cryopreserved ovarian tissue (OT) can successfully restore ovarian function in young cancer patients after gonadotoxic treatment. However, for patients with leukaemia, there is a risk of malignant cell transmission. Our objective was to evaluate minimal disseminated disease in OT from leukaemia patients and test a follicle isolation technique to obtain disease-free follicle suspensions. Cryopreserved OT from 12 leukaemia patients was thawed and analysed by histology and long-term xenografting in immunosuppressed mice...
April 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28417451/prophylactic-anti-staphylococcal-antibiotics-for-cystic-fibrosis
#14
REVIEW
Alan R Smyth, Margaret Rosenfeld
BACKGROUND: Staphylococcus aureus causes pulmonary infection in young children with cystic fibrosis. Prophylactic antibiotics are prescribed hoping to prevent such infection and lung damage. Antibiotics have adverse effects and long-term use might lead to infection with Pseudomonas aeruginosa. This is an update of a previously published review. OBJECTIVES: To assess continuous oral antibiotic prophylaxis to prevent the acquisition of Staphylococcus aureus versus no prophylaxis in people with cystic fibrosis, we tested these hypotheses...
April 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28416019/a-window-into-living-with-an-undiagnosed-disease-illness-narratives-from-the-undiagnosed-diseases-network
#15
Rebecca C Spillmann, Allyn McConkie-Rosell, Loren Pena, Yong-Hui Jiang, Kelly Schoch, Nicole Walley, Camilla Sanders, Jennifer Sullivan, Stephen R Hooper, Vandana Shashi
BACKGROUND: Patients' stories of their illnesses help bridge the divide between patients and providers, facilitating more humane medical care. Illness narratives have been classified into three types: restitution (expectation of recovery), chaos (suffering and loss), and quest (unexpected positive effect from illness). Undiagnosed patients have unique illness experiences and obtaining their narratives would provide insights into the medical and emotional impact of living with an undiagnosed illness...
April 17, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28413106/heterotopic-ossification-in-adults-following-a-burn-a-phenomenological-analysis
#16
Nichola Foster, Rachel Kornhaber, Sarah McGarry, Fiona M Wood, Dale W Edgar
Heterotopic Ossification (HO) is a rare but severely debilitating complication after a burn. Despite there being literature of varying quality explaining the postulated pathological process, risk factors and treatment for HO, the individual experiences of adults diagnosed with HO following a burn, remains unreported. This study sought to explore and describe burn survivors' experiences of HO to gain a greater understanding of the clinical needs for this unique patient population. A phenomenological inquiry of five men and one woman selected through purposeful sampling collected in-depth interviews analysed using Colaizzi's method of data analysis...
April 13, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28412229/characteristics-and-factors-associated-with-pain-in-older-homeless-individuals-results-from-the-hope-home-study
#17
John C Landefeld, Christine Miaskowski, Lina Tieu, Claudia Ponath, Christopher T Lee, David Guzman, Margot Kushel
Individuals experiencing homelessness in the United States are aging; little is known about chronic pain in this population. In a cross-sectional, population-based study, we interviewed 350 homeless individuals aged 50 and older to describe pain experienced by older persons experiencing homelessness and to assess factors associated with chronic moderate to severe pain, defined as pain lasting ≥3 months, with a past week average severity score of 5-10 (scale 0-10). The median age of participants was 58 years...
April 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28410876/the-treatment-of-fatigue-by-non-invasive-brain-stimulation
#18
REVIEW
Jean-Pascal Lefaucheur, Moussa A Chalah, Alaa Mhalla, Ulrich Palm, Samar S Ayache, Veit Mylius
The use of non-invasive brain neurostimulation (NIBS) techniques to treat neurological or psychiatric diseases is currently under development. Fatigue is a commonly observed symptom in the field of potentially treatable pathologies by NIBS, yet very little data has been published regarding its treatment. We conducted a review of the literature until the end of February 2017 to analyze all the studies that reported a clinical assessment of the effects of NIBS techniques on fatigue. We have limited our analysis to repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS)...
April 11, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28410655/tau-spread-apolipoprotein-e-inflammation-and-more-rapidly-evolving-basic-science-in-alzheimer-disease
#19
REVIEW
Bianca Gonzalez, Edsel M Abud, Abigail M Abud, Wayne W Poon, Karen H Gylys
To date, Alzheimer disease drug candidates have produced negative results in human trials, and progress in moving new targets out of the laboratory and into trials has been slow. However, based on 3 decades of previous work, there is reason to hope that amyloid-based and other novel therapies will move at a faster pace toward successful clinical trials. This article highlights selected preclinical research topics that are rapidly advancing in the laboratory.
May 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28410389/molecular-subtyping-of-treponema-pallidum-and-associated-factors-of-serofast-status-in-early-syphilis-patients-identified-novel-genotype-and-cytokine-marker
#20
Rui-Li Zhang, Qian-Qiu Wang, Jin-Ping Zhang, Li-Jia Yang
Serofast, a persistent nontreponemal serological response observed in early syphilis patients after conventional treatment, remains a concern of clinicians and syphilis patients. No consensus has been established, however, that defines an effective treatment strategy and clarifies the pathogenesis. In this study, 517 patients with early syphilis were enrolled and treated. Twelve months after treatment, 79.3% (410/517) of patients achieved serological cure, 20.1% (104/517) were serofast, and 0.6% (3/517) were serological failures...
2017: PloS One
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