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https://www.readbyqxmd.com/read/28934026/hope-distress-and-later-quality-of-life-among-adolescent-and-young-adults-with-cancer
#1
Abby R Rosenberg, Miranda C Bradford, Kira Bona, Michele L Shaffer, Joanne Wolfe, K Scott Baker, Nancy Lau, Joyce Yi-Frazier
We aimed to explore the predictive value of screening for distress alone, hope alone, or a combination of both. In a multi-center prospective study, 37 English-speaking Adolescents and Young Adults (AYAs) with cancer and 40 parents completed validated instruments at diagnosis ("baseline") and 3-6 months later ("follow-up"). Correlated regression models described associations. Within each instrument, baseline and follow-up scores were associated. However, only a composite hope/distress score predicted all three patient-centered outcomes...
September 21, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28929350/optimal-mri-sequences-for-68-ga-psma-11-pet-mri-in-evaluation-of-biochemically-recurrent-prostate-cancer
#2
Spencer T Lake, Kirsten L Greene, Antonio C Westphalen, Spencer C Behr, Ronald Zagoria, Eric J Small, Peter R Carroll, Thomas A Hope
BACKGROUND: PET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with (68)Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on (68)Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prostate cancer patients with BCR imaged with (68)Ga-PSMA-11 3.0T PET/MRI were retrospectively analyzed. Mean PSA was 7.9 ± 12.9 ng/ml, and mean PSA doubling time was 7...
September 19, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28929269/behavioral-health-integration-in-health-care-settings-lessons-learned-from-a-pediatric-hospital-primary-care-system
#3
Leandra Godoy, Melissa Long, Donna Marschall, Stacy Hodgkinson, Brooke Bokor, Hope Rhodes, Howard Crumpton, Mark Weissman, Lee Beers
Behavioral health integration within primary care has been evolving, but literature traditionally focuses on smaller scale efforts. We detail how behavioral health has been integrated across a large, urban pediatric hospital system's six primary care clinics (serving over 35,000 children annually and insured predominately through Medicaid) and discuss strategies for success in sustaining and expanding efforts to achieve effective integration of behavioral health into primary care. In a time span of 3 years, the clinics have implemented routine, universal behavioral health screening at well child visits, participated in a 15-month behavioral health screening quality improvement learning collaborative, and integrated the work of psychologists and psychiatrists...
September 19, 2017: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/28928357/successful-dual-kidney-transplantation-after-hypothermic-oxygenated-perfusion-of-discarded-human-kidneys
#4
Matteo Ravaioli, Vanessa De Pace, Giorgia Comai, Marco Busutti, Massimo Del Gaudio, Annalisa Amaduzzi, Alessandro Cucchetti, Antonio Siniscalchi, Gaetano La Manna, Antonietta A D D'Errico, Antonio Daniele Pinna
BACKGROUND The recovery of discarded human kidneys has increased in recent years and impels to use of unconventional organ preservation strategies that improve graft function. We report the first case of human kidneys histologically discarded and transplanted after hypothermic oxygenated perfusion (HOPE). CASE REPORT Marginal kidneys from a 78-year-old woman with brain death were declined by Italian transplant centers due to biopsy score (right kidney: 6; left kidney: 7). We recovered and preserved both kidneys through HOPE and we revaluated their use for transplantation by means of perfusion parameters...
September 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28922669/a-critical-commentary-on-the-2017-agnp-consensus-guidelines-for-therapeutic-drug-monitoring-in-neuropsychopharmacology
#5
Jose de Leon
In 2004, 2011, and 2017, the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP), a group of German-speaking psychiatric researchers and psychiatrists, published successive versions of therapeutic drug monitoring (TDM) expert group consensus guidelines. The 2017 version has as a major strength its encyclopedic nature, including 1358 references. The guideline has 3 major sections: 1) theoretical aspects of TDM, 2) drug concentration levels in blood to guide neuropsychopharmacotherapy, and 3) practical aspects of TDM in psychiatry and neurology...
September 18, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28922657/methods-employed-in-cytofluorometric-assessment-of-eryptosis-the-suicidal-erythrocyte-death
#6
Mohamed Jemaà, Myriam Fezai, Rosi Bissinger, Florian Lang
Suicidal erythrocyte death or eryptosis contributes to or even accounts for anemia in a wide variety of clinical conditions, such as iron deficiency, dehydration, hyperphosphatemia, vitamin D excess, chronic kidney disease (CKD), hemolytic-uremic syndrome, diabetes, hepatic failure, malignancy, arteriitis, sepsis, fever, malaria, sickle-cell disease, beta-thalassemia, Hb-C and G6PD-deficiency, Wilsons disease, as well as advanced age. Moreover, eryptosis is triggered by a myriad of xenobiotics and endogenous substances including cytotoxic drugs and uremic toxins...
September 1, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28921650/antibody-drug-conjugates-as-cancer-therapeutics-past-present-and-future
#7
Heather E Vezina, Monette Cotreau, Tae H Han, Manish Gupta
Antibody-drug conjugates (ADCs) represent an innovative therapeutic approach that provides novel treatment options and hope for patients with cancer. By coupling monoclonal antibodies (mAbs) to cytotoxic small-molecule payloads with a plasma-stable linker, ADCs offer the potential for increased drug specificity and fewer off-target effects than systemic chemotherapy. As evidence for the potential of these therapies, many new ADCs are in various stages of clinical development. Because their structure poses unique challenges to pharmacokinetic and pharmacodynamic characterization, it is critical to recognize the differences between ADCs and conventional chemotherapy in the design of ADC clinical development strategies...
October 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28921303/registry-study-to-assess-hair-loss-prevention-with-the-penguin-cold-cap-in-breast-cancer-patients-receiving-chemotherapy
#8
Brooke A Rice, Elizabeth S Ver Hoeve, Amy N DeLuca, Laura J Esserman, Hope S Rugo, Michelle E Melisko
PURPOSE: Chemotherapy-induced alopecia is a distressing side effect of cancer treatment. The aim of this registry study was to assess efficacy and tolerability of scalp hypothermia using Penguin Cold Caps (Penguin) in breast cancer patients. METHODS: Hair loss was assessed by patients using a 100-point Visual Analog Scale (VAS) and by physicians using the 5-point Dean Scale at baseline, every 3-4 weeks during chemotherapy, and at least 1 month after completion of chemotherapy...
September 18, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28920763/critique-of-the-iarc-100f-working-group-evaluation-of-occupational-benzene-exposure-suggestions-for-the-october-2017-benzene-only-working-group-meeting
#9
Melvyn Kopstein
Health agencies and institutions utilize International Agency for Research on Cancer (IARC) monographs because they are said to represent authoritative cancer evaluations and scientific references. The United States National Cancer Institute has provided support for the IARC Monographs Program for more than three decades. The Volume 100F Monograph, which was published in 2012, reports the evaluations of benzene and more than two dozen other agents performed by the IARC Working Group (WG) that met in Lyon, France from 20 to 27 October 2009...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28918182/uk-temporomandibular-joint-replacement-database-a-report-on-one-year-outcomes
#10
R Elledge, A Attard, J Green, D Lowe, S N Rogers, A J Sidebottom, B Speculand
Alloplastic temporomandibular joint (TMJ) replacements are increasingly subspecialised, and supraregional centres that treat sufficient numbers to ensure high standards are emerging. Having recently reported the introduction of a national TMJ joint replacement database that is endorsed by the British Association of TMJ Surgeons (BATS), we now present the first-year outcomes. This was a review of all data in the BATS National Case Registration of TMJ Replacement as of June 2014. A total of 252 one-year outcome records were available...
September 13, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28916948/viewer-discretion-advised-is-youtube-a-friend-or-foe-in-surgical-education
#11
H Alejandro Rodriguez, Monica T Young, Hope T Jackson, Brant K Oelschlager, Andrew S Wright
BACKGROUND: In the current era, trainees frequently use unvetted online resources for their own education, including viewing surgical videos on YouTube. While operative videos are an important resource in surgical education, YouTube content is not selected or organized by quality but instead is ranked by popularity and other factors. This creates a potential for videos that feature poor technique or critical safety violations to become the most viewed for a given procedure. METHODS: A YouTube search for "Laparoscopic cholecystectomy" was performed...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28915813/the-relationship-between-burden-of-childhood-disease-and-foreign-aid-for-child-health
#12
J Clay Bavinger, Paul Wise, Eran Bendavid
BACKGROUND: We sought to examine the relationship between child specific health aid (CHA) and burden of disease. Based on existing evidence, we hypothesized that foreign aid for child health would not be proportional to burden of disease. METHODS: In order to examine CHA and burden of disease, we obtained estimates of these parameters from established sources. Estimates of disability adjusted life years (DALYs) in children (0-5 years) were obtained from the World Health Organization for 2000 and 2012...
September 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28915271/extending-topological-surgery-to-natural-processes-and-dynamical-systems
#13
Stathis Antoniou, Sofia Lambropoulou
Topological surgery is a mathematical technique used for creating new manifolds out of known ones. We observe that it occurs in natural phenomena where a sphere of dimension 0 or 1 is selected, forces are applied and the manifold in which they occur changes type. For example, 1-dimensional surgery happens during chromosomal crossover, DNA recombination and when cosmic magnetic lines reconnect, while 2-dimensional surgery happens in the formation of tornadoes, in the phenomenon of Falaco solitons, in drop coalescence and in the cell mitosis...
2017: PloS One
https://www.readbyqxmd.com/read/28910933/-visual-spatial-and-temporal-characteristics-related-to-infectious-tuberculosis-epidemics-in-guangxi-zhuang-autonomous-region-2012-2015
#14
M Lin, Z Z Cui, D W Lin, D B Liang, M Y Huang, H B Su, X Y Tang
Objective: To study the spatial and temporal mode of infectious TB transmission in Guangxi Zhuang Autonomous Region (Guangxi). Methods: Data related to infectious TB case (Include smear and/or culture positive patients) in Guangxi were collected from the National Notifiable Disease Reported System (NNDRS) from 2010 to 2015. Spatial-temporal analysis and prediction were performed by SaTScan 7.0.2, GeoDa 1.8.12, R program v 3.3.1 and SPSS 19.0 software, using the time series model, Moran's I global and local spatial autocorrelation (Empirical Bayes adjustment)...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28905233/gated-thoracic-magnetic-resonance-angiography-at-3t-noncontrast-versus-blood-pool-contrast
#15
Chengcheng Zhu, Henrik Haraldsson, Kimberly Kallianos, Liang Ge, Elaine Tseng, Travis Henry, David Saloner, Michael D Hope
Both noncontrast and contrast-enhanced approaches to gated thoracic magnetic resonance angiography (MRA) for aortic root evaluation have been reported at 3T. We compare qualitative and quantitative image quality measures for the two approaches, and assess the reproducibility of standard aortic measurements. Respiratory and cardiac gated MRA of the chest was performed at 3T in 45 patients: 23 after administration of iron-based blood pool contrast, and 22 without contrast. Image quality was assessed with a 5-point Likert scale, vessel lumen-to-muscle contrast ratios, and vessel wall sharpness...
September 13, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28899362/nationwide-cross-sectional-survey-of-schistosomiasis-and-soil-transmitted-helminthiasis-in-sudan-study-protocol
#16
Seungman Cha, Sung-Tae Hong, Young-Ha Lee, Keon Hoon Lee, Dae Seong Cho, Jinmoo Lee, Jong-Yil Chai, Mousab Siddig Elhag, Soheir Gabralla Ahmad Khaled, Mustafa Khidir Mustafa Elnimeiri, Nahid Abdelgadeir Ali Siddig, Hana Abdelrazig, Sarah Awadelkareem, Azza Tag Eldin Elshafie, Hassan Ahmed Hassan Ahmed Ismail, Mutamad Amin
BACKGROUND: Schistosomiasis and soil-transmitted helminthiasis (STHs) are target neglected tropical diseases (NTDs) of preventive chemotherapy, but the control and elimination of these diseases have been impeded due to resource constraints. Few reports have described study protocol to draw on when conducting a nationwide survey. We present a detailed methodological description of the integrated mapping of schistosomiasis and STHs on the basis of our experiences, hoping that this protocol can be applied to future surveys in similar settings...
September 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28895261/the-effects-of-optimism-religion-and-hope-on-mood-and-anxiety-disorders-in-women-with-the-fmr1-premutation
#17
E P Lowell, B L Tonnsen, D B Bailey, J E Roberts
BACKGROUND: The FMR1 premutation, caused by a CGG trinucleotide repeat expansion on the FMR1 gene, has been identified as a genetic risk factor for mood and anxiety disorders. Building on recent studies identifying increased risk for mood and affective disorders in this population, we examined effects of potential protective factors (optimism, religion, hope) on depression and anxiety diagnoses in a prospective, longitudinal cohort. METHODS: Eighty-three women with the FMR1 premutation participated in the Structured Clinical Interview for DSM-IV-TR Disorders at two-time points, 3 years apart...
October 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28894513/diagnostic-methods-risk-factors-prevention-and-management-of-breast-cancer-related-lymphedema-past-present-and-future-directions
#18
Hoda E Sayegh, Maria S Asdourian, Meyha N Swaroop, Cheryl L Brunelle, Melissa N Skolny, Laura Salama, Alphonse G Taghian
PURPOSE OF REVIEW: Breast cancer-related lymphedema (BCRL) is a chronic, adverse, and much feared complication of breast cancer treatment, which affects approximately 20% of patients following breast cancer treatment. BCRL has a tremendous impact on breast cancer survivors, including physical impairments and significant psychological consequences. The intent of this review is to discuss recent studies and analyses regarding the risk factors, diagnosis, prevention through early screening and intervention, and management of BCRL...
June 2017: Current Breast Cancer Reports
https://www.readbyqxmd.com/read/28893743/an-analysis-of-redactions-in-canada-s-common-drug-review-clinical-review-reports-and-how-they-relate-to-the-patients-voice
#19
Allison Soprovich, Sylvia El Kurdi, Dean T Eurich
IMPORTANCE: Canada's Common Drug Review (CDR) evaluates drug data from published and unpublished research, as well as input from patient groups, to recommend provincial coverage. Currently, the CDR process gives manufacturers the opportunity to redact information in the final publicly available report. Patients often have strong feelings regarding the efficacy, harms, health-related quality of life (HRQL), and cost associated with the drugs under review and their redacted data. Highlighting Canada's approach will hopefully build on the growing international concern regarding transparency of clinical study data...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28891715/-where-it-falls-apart-barriers-to-retention-in-hiv-care-in-latino-immigrants-and-migrants
#20
Julie H Levison, Laura M Bogart, Iman F Khan, Dianna Mejia, Hortensia Amaro, Margarita Alegría, Steven Safren
Latino immigrants in the United States are disproportionately affected by HIV. Barriers to consistent attendance (retention) in HIV primary care constrain opportunities for HIV treatment success, but have not been specifically assessed in this population. We conducted semistructured interviews with 37 HIV-infected Latinos (aged ≥18 years and born in Puerto Rico or a Latin American Spanish-speaking country) and 14 HIV providers in metropolitan Boston (total n = 51). The Andersen Model of Healthcare Utilization informed a semistructured interview guide, which bilingual research staff used to explore barriers to HIV care...
September 2017: AIDS Patient Care and STDs
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