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https://www.readbyqxmd.com/read/28344570/tanycytes-as-regulators-of-seasonal-cycles-in-neuroendocrine-function
#1
REVIEW
Jo E Lewis, Francis J P Ebling
Annual cycles of physiology and behavior are highly prevalent in organisms inhabiting temperate and polar regions. Examples in mammals include changes in appetite and body fat composition, hibernation and torpor, growth of antlers, pelage and horns, and seasonal reproduction. The timing of these seasonal cycles reflects an interaction of changing environmental signals, such as daylength, and intrinsic rhythmic processes: circannual clocks. As neuroendocrine signals underlie these rhythmic processes, the focus of most mechanistic studies has been on neuronal systems in the hypothalamus...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28340062/exogenously-applied-24-epibrassinolide-ebl-ameliorates-detrimental-effects-of-salinity-by-reducing-k-efflux-via-depolarization-activated-k-channels
#2
Nazila Azhar, Nana Su, Lana Shabala, Sergey Shabala
This study has investigated mechanisms conferring beneficial effects of exogenous application of 24-epibrassinolides (EBL) on plant growth and performance under saline conditions. Barley seedlings treated with 0.25 mg l-1 EBL showed significant improvements in root hair length, shoot length, shoot fresh weight and relative water content when grown in the presence of 150 mM NaCl in the growth medium. In addition, EBL treatment significantly decreased the Na+ content in both shoots (by approximately 50%) and roots...
March 2, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28337234/is-computerised-tomography-better-than-fibreoptic-gastroscopy-for-early-detection-of-gastric-varices
#3
Burak Suvak, Murat Kekilli, Yavuz Beyazıt, Sarper Okten, Alpaslan Tanoglu, Nurgul Sasmaz
INTRODUCTION: Video endoscopic diagnosis of gastric varices is particularly limited, owing to the deep submucosal or subserosal location of the varices and the normal appearance of the overlying mucosa. AIM: We present and emphasise the value of computerised tomography (CT) examination in the early detection of gastric varices (GVs). MATERIAL AND METHODS: In this retrospective study, a total of 216 consecutive patients with cirrhosis were evaluated at the Turkiye Yuksek Ihtisas Training and Research Hospital between September 2008 and March 2011...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28336475/intraoperative-rupture-of-ovarian-dermoid-cysts-in-the-pediatric-and-adolescent-population-should-this-change-your-surgical-management
#4
Krista J Childress, Gisselle Perez-Milicua, Julie Hakim, Oluyemisi Adeyemi-Fowode, Jennifer L Bercaw-Pratt, Xiomara M Santos, Jennifer E Dietrich
STUDY OBJECTIVE: 1) To determine the incidence of chemical peritonitis after cystectomy for ovarian dermoid cysts with intraoperative cyst rupture in the pediatric and adolescent population. 2) To examine the intraoperative and postoperative outcomes of cystectomies performed for ovarian dermoid cysts by laparoscopy and laparotomy, especially those with intraoperative cyst rupture. DESIGN: A retrospective cohort study of females who underwent ovarian cystectomy with proven ovarian dermoid pathology between July 2007 and July 2015...
March 20, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28317486/abnormal-clock-gene-expression-and-locomotor-activity-rhythms-in-two-month-old-female-appswe-ps1de9-mice
#5
Olaide Oyegbami, Hilary M Collins, Marie C Pardon, Fran Jp Ebling, David M Heery, Paula M Moran
In addition to cognitive decline, Alzheimer's disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or at night and have been referred to as 'sundowning'. These symptoms are especially difficult for carers and there are no specific drug treatments. There is increasing evidence that these symptoms reflect an underlying pathology of circadian rhythm generation and transmission. We investigated whether a transgenic mouse model relevant to AD (APPswe/PS1dE9) exhibits circadian alterations in locomotor activity and expression of clock genes involved in the regulation of the circadian cycle...
March 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28315424/diagnostic-criteria-for-oncocytic-renal-neoplasms-a-survey-of-urologic-pathologists
#6
Sean R Williamson, Ramya Gadde, Kiril Trpkov, Michelle S Hirsch, John R Srigley, Victor E Reuter, Liang Cheng, L Priya Kunju, Ravi Barod, Craig G Rogers, Brett Delahunt, Ondrej Hes, John N Eble, Ming Zhou, Jesse K McKenney, Guido Martignoni, Stewart Fleming, David J Grignon, Holger Moch, Nilesh S Gupta
Renal oncocytoma and chromophobe renal cell carcinoma (RCC) have been long recognized as distinct tumors; however, it remains unknown if uniform diagnostic criteria are used to distinguish these tumor types in practice. A survey was distributed to urologic pathologists regarding oncocytic tumors. Responses were received from 17/26 invitees. Histologically, >1 mitotic figure was regarded as most worrisome (n=10) or incompatible (n=6) with oncocytoma diagnosis. Interpretation of focal nuclear wrinkling, focal perinuclear clearing, and multinucleation depended on extent and did not necessarily exclude oncocytoma if minor...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28296036/targeting-of-c-type-lectin-like-receptor-2-or-p2y12-for-the-prevention-of-platelet-activation-by-immunotherapeutic-cpg-oligodeoxynucleotides
#7
C Delierneux, N Donis, L Servais, O Wéra, C Lecut, M Vandereyken, L Musumeci, S Rahmouni, J Schneider, J A Eble, P Lancellotti, C Oury
BACKGROUND: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment. Unexpectedly, a recent study indicates that CpG ODNs activate human platelets via the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptor glycoprotein VI. OBJECTIVE: To further analyze the mechanisms of CpG ODN-induced platelet activation and identify potential inhibitory strategies...
March 11, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28288789/blood-loss-at-the-time-of-surgical-abortion-up-to-14weeks-in-anticoagulated-patients-a-case-series
#8
Bliss Kaneshiro, Mary Tschann, Jeffrey Jensen, Paula Bednarek, Ronnie Texeira, Alison Edelman
OBJECTIVE: To describe estimated blood loss (EBL) with surgical abortion≤14weeks gestation in anticoagulated patients. STUDY DESIGN: We invited 170 clinicians involved in a professional listserv to report cases when they performed a surgical abortion on a patient≤14weeks gestation taking an anticoagulant. Clinicians reported estimated blood loss (EBL) and bleeding-related complications (need for a blood transfusion, additional surgical procedures to treat bleeding)...
March 10, 2017: Contraception
https://www.readbyqxmd.com/read/28284576/hemostasis-in-endoscopic-endonasal-skull-base-surgery-using-the-aquamantys-bipolar-sealer-technical-note
#9
Richard Bram, Susan Fiore, Daryl McHugh, Ghassan J Samara, Raphael P Davis
BACKGROUND: A major challenge during endoscopic transsphenoidal surgery is adequate intraoperative hemostasis. The Aquamantys® is a relatively new bipolar sealing device which uses radiofrequency energy and saline. This promotes hemostasis while decreasing charring and thermal spread. In this paper, we describe our experience with the Aquamantys® Mini EVS 3.4 Epidural Vein Sealer Bipolar Electrocautery System (Medtronic Advanced Energy, Portsmouth, NH, USA) during endoscopic surgery for tumors of the skull base with particular attention to ergonomic benefits and technical nuances...
March 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28281740/comparison-of-laparoendoscopic-single-site-less-and-multiport-laparoscopic-radical-nephrectomy-for-clinical-t1b-and-t2a-renal-masses
#10
Abd-El R Hassan, Omer A Raheem, Sean Berquist, Alp T Beksac, Aaron Bloch, Charles Field, Hak J Lee, Reza Mehrazin, Marc Holden, Michelle McDONALD, Zachary Hamilton, Michael Liss, Ithaar H Derweesh
BACKGROUND: To compare outcomes of Laparoendoscopic single-site surgery (LESS) and multiport laparoscopic (MPL) Radical Nephrectomy (RN) for clinical T1b/T2a renal masses, as concerns continue regarding suitability and benefit of LESS for larger renal masses. METHODS: Retrospective single-surgeon comparison of LESS- and MPL-RN between 7/2005 and 11/2014. 63 patients underwent LESS-RN (44 cT1b/19 cT2a); 133 underwent MPL (83 cT1b/50 cT2a). All patients were managed with a standardized care pathway...
March 10, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28281246/localized-surface-plasmon-resonance-lspr-coupled-fiber-optic-nanoprobe-for-the-detection-of-protein-biomarkers
#11
Jianjun Wei, Zheng Zeng, Yongbin Lin
Here is presented a miniaturized, fiber-optic (FO) nanoprobe biosensor based on the localized surface plasmon resonance (LSPR) at the reusable dielectric-metallic hybrid interface with a robust, gold nano-disk array at the fiber end facet. The nanodisk array is directly fabricated using electron beam lithography (EBL) and metal lift-off process. The free prostate-specific antigen (f-PSA) has been detected with a mouse anti-human prostate-specific antigen (PSA) monoclonal antibody (mAb) as a specific receptor linked with a self-assembled monolayer (SAM) at the LSPR-FO facet surfaces...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28266814/predicting-outcomes-in-partial-nephrectomy-is-the-renal-score-useful
#12
André Costa Matos, Marcos F Dall'Oglio, José Roberto Colombo, Alexandre Crippa, João A Q Juveniz, Felipe Coelho Argolo
INTRODUCTION AND OBJECTIVE: The R.E.N.A.L. nephrometry system (RNS) has been validated in multiple open, laparoscopic and robotic partial nephrectomy series. The aim of this study was to test the accuracy of R.E.N.A.L. nephrometry system in predicting perioperative outcomes in surgical treatment of kidney tumors <7.0cm in a prospective model. MATERIALS AND METHODS: Seventy-one patients were selected and included in this prospective study. We evaluate the accuracy of RNS in predicting perioperative outcomes (WIT, OT, EBL, LOS, conversion, complications and surgical margins) in partial nephrectomy using ROC curves, univariate and multivariate analyses...
March 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28264207/hemostatic-resuscitation-in-peripartum-hysterectomy-pre-and-postmassive-transfusion-protocol-initiation
#13
Eryn H Dutta, Aaron T Poole, Faranak Behnia, Holly E Dunn, Shannon M Clark, Luis D Pacheco, George R Saade, Gary D V Hankins
Background Massive transfusion protocols (MTPs) have been examined in trauma. The exact ratio of packed red blood cells (PRBC) to other blood replacement components in hemostatic resuscitation in obstetrics has not been well defined. Objective The objective of this study was to evaluate hemostatic resuscitation in peripartum hysterectomy comparing pre- and postinstitution of a MTP. Study Design We conducted a retrospective, descriptive study of women undergoing peripartum hysterectomies from January 2002 to January 2015 who received ≥ 4 units of PRBC...
March 6, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28258304/orthopaedic-trauma-surgeons-and-direct-anterior-total-hip-arthroplasty-evaluation-of-learning-curve-at-a-level-i-academic-institution
#14
Philip J York, Stephanie L Logterman, David J Hak, Andreas Mavrogenis, Cyril Mauffrey
BACKGROUND: Interest in the direct anterior approach for total hip arthroplasty has increased over recent years; however, the potential for substantial complications exists, especially during the surgeon's learning curve. We evaluated the change in various metrics to help identify a single surgeon's learning curve. Additionally, we examined whether the learning curve was different for primarily arthroplasty versus trauma-trained surgeons. METHODS: We reported outcomes from the first 50 total hip arthroplasties performed through a direct anterior approach by a trauma fellowship-trained orthopaedic surgeon...
March 3, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28256451/towards-low-dimensional-hole-systems-in-be-doped-gaas-nanowires
#15
A R Ullah, J G Gluschke, P Krogstrup, C B Sørensen, J Nygård, A P Micolich
GaAs was central to the development of quantum devices but is rarely used for nanowire-based quantum devices with InAs, InSb and SiGe instead taking the leading role. p-type GaAs nanowires offer a path to studying strongly confined 0D and 1D hole systems with strong spin-orbit effects, motivating our development of nanowire transistors featuring Be-doped p-type GaAs nanowires, AuBe alloy contacts and patterned local gate electrodes towards making nanowire-based quantum hole devices. We report on nanowire transistors with traditional substrate back-gates and EBL-defined metal/oxide top-gates produced using GaAs nanowires with three different Be-doping densities and various AuBe contact processing recipes...
March 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28251636/placenta-praevia-and-the-risk-of-adverse-outcomes-during-second-trimester-abortion-a-retrospective-cohort-study
#16
Lisa K Perriera, Alan A Arslan, Rachel Masch
BACKGROUND: There are few reports in the literature of the risks associated with second trimester abortion in women with placenta praevia (PP). We hypothesise that PP increases the risk of complications. AIMS: We sought to determine if PP is associated with a higher risk of blood loss and blood transfusion at the time of dilation and evacuation (D&E). MATERIALS AND METHODS: The records of 612 consecutive women undergoing abortion at 15-24 weeks of gestation were reviewed...
February 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28246386/mycoplasma-bovis-nadh-oxidase-functions-as-both-a-nadh-oxidizing-and-o2-reducing-enzyme-and-an-adhesin
#17
Gang Zhao, Hui Zhang, Xi Chen, Xifang Zhu, Yusi Guo, Chenfei He, Farhan Anwar Khan, Yingyu Chen, Changmin Hu, Huanchun Chen, Aizhen Guo
Mycoplasma bovis causes considerable economic losses in the cattle industry worldwide. In mycoplasmal infections, adhesion to the host cell is of the utmost importance. In this study, the amino acid sequence of NOX was predicted to have enzymatic domains. The nox gene was then cloned and expressed in Escherichia coli. The enzymatic activity of recombinant NOX (rNOX) was confirmed based on its capacity to oxidize NADH to NAD(+) and reduce O2 to H2O2. The adherence of rNOX to embryonic bovine lung (EBL) cells was confirmed with confocal laser scanning microscopy, enzyme-linked immunosorbent assay, and flow cytometry...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28243380/patient-reported-outcomes-from-sacroiliac-joint-fusion
#18
Vamsi K Kancherla, Shane M McGowan, Brittany N Audley, Gbolabo Sokunbi, Steven T Puccio
STUDY DESIGN: Retrospective, case series. PURPOSE: The purpose of this study is to determine morbidity, complications, and patient reported outcomes from minimally invasive sacroiliac joint (SIJ) fusion. OVERVIEW OF LITERATURE: Lumbar back pain emanating from the SIJ can be surgically treated via a percutaneous approach in the appropriately selected patient with minimal morbidity and acceptable functional outcomes. METHODS: Patients diagnosed by >2 physical examination maneuvers and subjective relief from a computed tomography-guided lidocaine-bupivacaine-steroid injection underwent SIJ fusion after failing conservative management with a combination of oral anti-inflammatory medications, physical therapy, and pelvic belt stabilization...
February 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28241523/cmos-compatible-fabrication-of-micro-nano-convex-silicon-lens-arrays-by-conformal-chemical-vapor-deposition
#19
Haijie Zuo, Duk-Yong Choi, Xin Gai, Barry Luther-Davies, Baoping Zhang
We present a novel CMOS-compatible fabrication technique for convex micro-nano lens arrays (MNLAs) with high packing density on the wafer scale. By means of conformal chemical vapor deposition (CVD) of hydrogenated amorphous silicon (a-Si:H) following patterning of silicon pillars via electron beam lithography (EBL) and plasma etching, large areas of a close packed silicon lens array with the diameter from a few micrometers down to a few hundred nanometers was fabricated. The resulting structure shows excellent surface roughness and high uniformity...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28224214/predictors-of-the-outcome-of%C3%A2-lumbar-disc-herniation-following-classical-surgery-laminotomy-with-discectomy
#20
Augustine Balaara, Xiao-Feng Xu, Young-Hui Huang, Li Dapeng
BACKGROUND: Several surgical variables and patient characteristics play an influential role in the prognosis of lumbar disc herniation following laminotomy with discectomy. This paper seeks to evaluate the perioperative predictor variables for the outcome of lumbar disc herniation. PATIENTS AND METHODS: From October 2013 to July 2016, 166 surgical patients were evaluated using prospectively collected data. Patients' preoperative independent variables (age, sex, body mass index, level of disc herniation, pain duration, and American Society of Anesthesiologists Physical Score) were correlated with functional outcome measures such as primary outcome measures (length of hospital stay; postoperative visual analog scale, VAS; Oswestry disability index, ODI) and secondary outcome measures (operation room time; estimated intraoperative blood loss, EBL; complications; readmission) as dependent variables...
February 21, 2017: Der Orthopäde
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