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https://www.readbyqxmd.com/read/28739123/effects-of-modifiable-non-modifiable-and-clinical-process-factors-in-ventral-hernia-repair-surgical-site-infections-a-retrospective-study
#1
John Chipko, Anthony DeSantis, Erik Quinn, Vic Velanovich
BACKGROUND: The hypothesis of this study is that non-modifiable factors are more important in ventral hernia repair (VHR) surgical site infection (SSI) than care process factors. METHODS: All VHR's which were reviewed retrospectively for both NSQIP-recorded data, and also: preoperative hospitalization, existing mesh, enterocutaneous fistula, open wound, case month, case day, case length, prophylactic antibiotics, skin preparation, other procedure performed, re-do operation, estimate blood loss, hernia size, repair approach, repair type, mesh used, skin closure, suture type, use of drains, and dressing...
July 19, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28727381/nephrometry-scores-and-perioperative-outcomes-following-robotic-partial-nephrectomy
#2
Renato B Corradi, Emily A Vertosick, Daniel P Nguyen, Antoni Vilaseca, Daniel D Sjoberg, Nicole Benfante, Lucas N Nogueira, Massimiliano Spaliviero, Karim A Touijer, Paul Russo, Jonathan A Coleman
OBJECTIVES: Based on imaging features, nephrometry scoring systems have been conceived to create a standardized and reproducible way to characterize renal tumor anatomy. However, less is known about which of these individual measures are important with regard to clinically relevant perioperative outcomes such as ischemia time (IT), estimated blood loss (EBL), length of hospital stay (LOS), and change in estimated glomerular filtration rate (eGFR) after robotic partial nephrectomy (PN)...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28727367/prospective-evaluation-of-vesicourethral-anastomosis-outcomes-in-robotic-radical-prostatectomy-during-early-experience-in-a-university-hospital
#3
Lucas Medeiros Burttet, Gabrielle Aguiar Varaschin, Andre Kives Berger, Leandro Totti Cavazzola, Milton Berger, Brasil Silva
PURPOSE: Robotic assisted radical prostatectomy (RARP) presents challenges for the surgeon, especially during the initial learning curve. We aimed to evaluate early and mid-term functional outcomes and complications related to vesicourethral anastomosis (VUA), in patients who underwent RARP, during the initial experience in an academic hospital. We also assessed possible predictors of postoperative incontinence and compared these results with the literature. MATERIALS AND METHODS: We prospectively collected data from consecutive patients that underwent RARP...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28726145/robotic-gastric-bypass-may-lead-to-fewer-complications-compared-with-laparoscopy
#4
Dimitrios Stefanidis, Savannah B Bailey, Timothy Kuwada, Connie Simms, Keith Gersin
BACKGROUND: Robotic technology leads to improved visualization and precision over laparoscopy but also higher cost of care. The benefits of this technology to patient outcomes are controversial. Our objective was to assess whether the application of robotic surgery to Roux-en-Y gastric bypass (RYGB) would lead to improved patient outcomes. METHODS: A prospectively collected database at a bariatric center of excellence was reviewed for all RYGB procedures performed by one surgeon between 2007 and 2015...
July 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28723878/evolution-of-surgery-for-adolescent-idiopathic-scoliosis-over-20-years-have-outcomes-improved
#5
Baron S Lonner, Yuan Ren, Burt Yaszay, Patrick J Cahill, Suken A Shah, Randal R Betz, Amer F Samdani, Harry L Shufflebarger, Peter O Newton
STUDY DESIGN: Retrospective review of a prospective Adolescent Idiopathic Scoliosis (AIS) registry OBJECTIVE.: To study the evolution of the operative approach, outcomes and complication rates in AIS surgery over the past 20 years. METHODS: 1819 AIS patients (1995-2013) with 2-year F/U were studied. Operative approach, perioperative parameters, major complication rates, and SRS outcomes were assessed. Linear regression was used to assess the trend of changes over 5-year quartiles...
July 18, 2017: Spine
https://www.readbyqxmd.com/read/28723798/the-safety-and-effectiveness-of-robot-assisted-versus-laparoscopic-tme-in-patients-with-rectal-cancer-a-meta-analysis-and-systematic-review
#6
Xiaofei Li, Tao Wang, Liang Yao, Lidong Hu, Penghui Jin, Tiankang Guo, Kehu Yang
BACKGROUND: The aim of this study was to assess the safety and effectiveness of robotic-assisted versus laparoscopic total mesorectal excision (TME) in patients with rectal cancer. METHODS: We systematically searched PubMed, EMBASE, Cochrane library, Web of science, and Chinese Biomedical Literature Database up to July 2016 to identify case-controlled studies that compared robotic TME (RTME) with laparoscopic TME (LTME) for rectal cancer. GRADE was used to interpret the primary outcomes of this meta-analysis...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28717275/initial-experience-of-robotic-nephron-sparing-surgery-in-cases-of-high-renal-nephrometry-scores
#7
Girdhar S Bora, Ravimohan S Mavuduru, Aditya P Sharma, Sudheer K Devana, Nandita Kakkar, Anupam Lal, Shrawan K Singh, Arup K Mandal
INTRODUCTION: The renal nephrometry scoring (RNS) system enables prediction the feasibility of nephron-sparing surgery (NSS) in renal masses. There is insufficient data regarding the outcome of robot-assisted NSS in tumors with RNS ≥10. We reviewed the trifecta outcomes of patients undergoing robotic NSS with high RNS and compare it with tumors of low and intermediate RNS. MATERIALS AND METHODS: Our prospectively maintained data of all robot-assisted NSS were reviewed, and those with RNS of ≥10 were identified...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28708777/intraoperative-topical-antibiotics-for-infection-prophylaxis-in-pelvic-and-acetabular-surgery
#8
Matthew T Owen, Emily M Keener, Zane B Hyde, Reaves M Crabtree, Parke W Hudson, Russell L Griffin, Jason A Lowe
OBJECTIVES: Determine if topical vancomycin and tobramycin powder reduces the incidence of surgical site infection (SSI) following pelvic ring and acetabulum fracture surgery. DESIGN: Retrospective cohort study SETTING:: University of Alabama at Birmingham, Academic Level I Trauma Center PATIENTS/PARTICIPANTS:: 219 patients (140 meeting inclusion criteria) with pelvic and acetabular fractures who underwent open reduction and internal fixation (ORIF) from March 2012 to November 2013...
June 26, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28704525/rapid-identification-of-genes-controlling-virulence-and-immunity-in-malaria-parasites
#9
Hussein M Abkallo, Axel Martinelli, Megumi Inoue, Abhinay Ramaprasad, Phonepadith Xangsayarath, Jesse Gitaka, Jianxia Tang, Kazuhide Yahata, Augustin Zoungrana, Hayato Mitaka, Arita Acharjee, Partha P Datta, Paul Hunt, Richard Carter, Osamu Kaneko, Ville Mustonen, Christopher J R Illingworth, Arnab Pain, Richard Culleton
Identifying the genetic determinants of phenotypes that impact disease severity is of fundamental importance for the design of new interventions against malaria. Here we present a rapid genome-wide approach capable of identifying multiple genetic drivers of medically relevant phenotypes within malaria parasites via a single experiment at single gene or allele resolution. In a proof of principle study, we found that a previously undescribed single nucleotide polymorphism in the binding domain of the erythrocyte binding like protein (EBL) conferred a dramatic change in red blood cell invasion in mutant rodent malaria parasites Plasmodium yoelii...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28704364/dramatic-and-concerted-conformational-changes-enable-rhodocetin-to-block-%C3%AE-2%C3%AE-1-integrin-selectively
#10
Johannes A Eble, Matthew McDougall, George L Orriss, Stephan Niland, Benjamin Johanningmeier, Gottfried Pohlentz, Markus Meier, Simone Karrasch, Maria Inacia Estevão-Costa, Augusto Martins Lima, Jörg Stetefeld
The collagen binding integrin α2β1 plays a crucial role in hemostasis, fibrosis, and cancer progression amongst others. It is specifically inhibited by rhodocetin (RC), a C-type lectin-related protein (CLRP) found in Malayan pit viper (Calloselasma rhodostoma) venom. The structure of RC alone reveals a heterotetramer arranged as an αβ and γδ subunit in a cruciform shape. RC specifically binds to the collagen binding A-domain of the integrin α2 subunit, thereby blocking collagen-induced platelet aggregation...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28704150/measurement-of-ph-exudate-composition-and-temperature-in-wound-healing-a-systematic-review
#11
G Power, Z Moore, T O'Connor
OBJECTIVE: To assess the potential of measurements of pH, exudate composition and temperature in wounds to predict healing outcomes and to identify the methods that are employed to measure them. METHOD: A systematic review based on the outcomes of a search strategy of quantitative primary research published in the English language was conducted. Inclusion criteria limited studies to those involving in vivo and human participants with an existing or intentionally provoked wound, defined as 'a break in the epithelial integrity of the skin', and excluded in vitro and animal studies...
July 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28698990/explanation-based-learning-in-infancy
#12
Renée Baillargeon, Gerald F DeJong
In explanation-based learning (EBL), domain knowledge is leveraged in order to learn general rules from few examples. An explanation is constructed for initial exemplars and is then generalized into a candidate rule that uses only the relevant features specified in the explanation; if the rule proves accurate for a few additional exemplars, it is adopted. EBL is thus highly efficient because it combines both analytic and empirical evidence. EBL has been proposed as one of the mechanisms that help infants acquire and revise their physical rules...
July 11, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28696140/regulatory-roles-of-24-epibrassinolide-in-tolerance-of-acacia-gerrardii-benth-to-salt-stress
#13
Elsayed Fathi Abd Allah, A A Alqarawi, Abeer Hashem, Stephan Wirth, Dilfuza Egamberdieva
This experiment aimed to investigate the role of 24-epibrassinolide (EBL) against NaCl-induced salinity stress in Acacia gerrardii Benth. NaCl (200 mM) imparted deleterious effects on the growth and chlorophyll contents of A. gerrardii, but foliar application of EBL (1.0 mg/l; each plant received 2.5 ml) mitigated the negative effect considerably. NaCl reduced chlorophyll content but this was significantly ameliorated by the application of EBL. EBL reduced significantly NaCl-induced oxidative stress hence protect membranes and also improved the relative water content significantly by 6...
July 11, 2017: Bioengineered
https://www.readbyqxmd.com/read/28689939/variation-in-transfusion-practices-and-the-association-with-perioperative-adverse-events-in-patients-undergoing-open-abdominal-aortic-aneurysm-repair-and-lower-extremity-arterial-bypass-in-the-vascular-quality-initiative
#14
Zachary Osborne, Kristine Hanson, Benjamin S Brooke, Marc Schermerhorn, Peter Henke, Rumi Faizer, Andres Schanzer, Philip Goodney, Thomas Bower, Randall R DeMartino
INTRODUCTION: Blood transfusions are associated with adverse events. We examined perioperative transfusion practices and associated complications following open vascular procedures nationwide in the Vascular Quality Initiative (VQI). METHODS: Adults undergoing open abdominal aortic aneurysm repair (OAR) and lower extremity arterial bypass (Bypass) within VQI (2003-2016) were identified. All emergent cases, patients with pre-operative hemoglobin<7 g/dL, pre-operative hospitalization >1 day, or a return to OR during the index hospitalization were excluded...
July 6, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28680778/transforaminal-lumbar-interbody-fusion-with-rigid-interspinous-process-fixation-a-learning-curve-analysis-of-a-surgeon-team-s-first-74-cases
#15
Patrick Doherty, Arthur Welch, Jason Tharpe, Camille Moore, Chris Ferry
BACKGROUND: Studies have shown that a significant learning curve may be associated with adopting minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) with bilateral pedicle screw fixation (BPSF). Accordingly, several hybrid TLIF techniques have been proposed as surrogates to the accepted BPSF technique, asserting that less/fewer fixation(s) or less disruptive fixation may decrease the learning curve while still maintaining the minimally disruptive benefits. TLIF with interspinous process fixation (ISPF) is one such surrogate procedure...
May 30, 2017: Curēus
https://www.readbyqxmd.com/read/28679176/comparison-of-robotic-and-laparoscopic-partial-nephrectomy-for-small-renal-tumours
#16
Abdulmuttalip Simsek, Abdullah Hizir Yavuzsan, Yunus Colakoglu, Arda Atar, Selcuk Sahin, Volkan Tugcu
OBJECTIVE: To evaluate a single surgeon oncological and functional outcomes of laparoscopic partial nephrectomy (LPN) compared to robotic partial nephrectomy (RPN) for pT1a renal tumours. MATERIALS AND METHODS: Between 2006 and 2016, a retrospective review of 42 patients who underwent LPN (n = 20) or RPN (n = 22) by same surgeon was performed. Patients were matched for gender, age, body mass index (BMI), American Society of Anaesthesiologists (ASA) score, tumour side, RENAL and PADUA scores, peri-operative and post-operative outcomes...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28678849/community-health-promotion-and-medical-provision-for-neonatal-health-champion-cluster-randomised-trial-in-nagarkurnool-district-telangana-formerly-andhra-pradesh-india
#17
RANDOMIZED CONTROLLED TRIAL
Peter Boone, Alex Eble, Diana Elbourne, Chris Frost, Chitra Jayanty, Rashmi Lakshminarayana, Vera Mann, Rohini Mukherjee, Gilda Piaggio, Padmanabh Reddy
BACKGROUND: In the mid-2000s, neonatal mortality accounted for almost 40% of deaths of children under 5 years worldwide, and constituted 65% of infant deaths in India. The neonatal mortality rate in Andhra Pradesh was 44 per 1,000 live births, and was higher in the rural areas and tribal regions, such as the Nagarkurnool division of Mahabubnagar district (which became Nagarkurnool district in Telangana in 2014). The aim of the CHAMPION trial was to investigate whether a package of interventions comprising community health promotion and provision of health services (including outreach and facility-based care) could lead to a reduction of the order of 25% in neonatal mortality...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28667776/preservation-of-truncal-genomic-alterations-in-clear-cell-and-papillary-renal-cell-carcinomas-with-sarcomatoid-features-an-intra-and-intertumoral-multifocal-fluorescence-in-situ-hybridization-analysis-reveals-limited-genetic-heterogeneity
#18
Joseph M Sanfrancesco, John N Eble, David J Grignon, Mingsheng Wang, Shaobo Zhang, Chandru P Sundaram, Muhammad T Idrees, Roberto Pili, Erik Kouba, Liang Cheng
Understanding tumor genomic heterogeneity may offer vital information in an age of targeted therapy for renal cell carcinoma. We sought to investigate hallmark truncal chromosomal alterations between conventional, sarcomatoid, and matched metastatic tumor foci in clear cell and papillary renal cell carcinomas. A retrospective review identified 58 cases including clear cell (CCRCC) and papillary renal cell carcinomas (PRCC). All cases contained sarcomatoid transformation. Additionally, 10 of 58 patients had matched metastatic disease available for analysis...
July 1, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28666136/the-biological-significance-of-bornavirus-derived-genes-in-mammals
#19
REVIEW
Masayuki Horie
The discoveries of sequences derived from non-retroviral viruses in eukaryotic genomes have significantly expanded our knowledge about virus evolution as well as the co-evolution between viruses and eukaryotes. However, the biological functions of such sequences in the host are largely unknown. Endogenous bornavirus-like elements (EBLs) have been relatively well studied by molecular biological methods, which have provided evidence that some EBLs have been co-opted by their hosts. This review highlights the current knowledge on the biological significance of EBLs, and discusses possible functions of EBLs...
June 27, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28660112/vertebral-column-resection-for-rigid-spinal-deformity
#20
REVIEW
Comron Saifi, Joseph L Laratta, Petros Petridis, Jamal N Shillingford, Ronald A Lehman, Lawrence G Lenke
STUDY DESIGN: Broad narrative review. OBJECTIVE: To review the evolution, operative technique, outcomes, and complications associated with posterior vertebral column resection. METHODS: A literature review of posterior vertebral column resection was performed. The authors' surgical technique is outlined in detail. The authors' experience and the literature regarding vertebral column resection are discussed at length. RESULTS: Treatment of severe, rigid coronal and/or sagittal malalignment with posterior vertebral column resection results in approximately 50-70% correction depending on the type of deformity...
May 2017: Global Spine Journal
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