Azliza Mad Anuar, Akira Minami, Hiroshi Matsushita, Kanako Ogino, Kosei Fujita, Hatsune Nakao, Shota Kimura, Vikineswary Sabaratnam, Kaoru Umehara, Yuuki Kurebayashi, Tadanobu Takahashi, Hiroaki Kanazawa, Akihiko Wakatsuki, Takashi Suzuki, Hideyuki Takeuchi
Estrogen deficiency during menopause causes a variety of neurological symptoms, including depression. The edible Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (HE), is a medicinal mushroom that has the potential for a neuroprotective effect and ameliorating neurological diseases, such as depression, anxiety, and neurodegenerative diseases. HE contains phytoestrogens, including daidzein and genistein. However, the ameliorating effect of HE on menopausal symptoms is not well understood. Here we investigated the impact of methanol extract of the HE fruiting body on depressive-like behavior in postmenopausal model rats...
2022: Biological & Pharmaceutical Bulletin