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https://www.readbyqxmd.com/read/28860534/genomic-and-transcriptomic-analyses-reveal-differential-regulation-of-diverse-terpenoid-and-polyketides-secondary-metabolites-in-hericium-erinaceus
#1
Juan Chen, Xu Zeng, Yan Long Yang, Yong Mei Xing, Qi Zhang, Jia Mei Li, Ke Ma, Hong Wei Liu, Shun Xing Guo
The lion's mane mushroom Hericium erinaceus is a famous traditional medicinal fungus credited with anti-dementia activity and a producer of cyathane diterpenoid natural products (erinacines) useful against nervous system diseases. To date, few studies have explored the biosynthesis of these compounds, although their chemical synthesis is known. Here, we report the first genome and tanscriptome sequence of the medicinal fungus H. erinaceus. The size of the genome is 39.35 Mb, containing 9895 gene models. The genome of H...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845772/volatile-composition-of-some-cultivated-and-wild-culinary-medicinal-mushrooms-from-hungary
#2
Mariann Csóka, Andras Geosel, Maria Amtmann, Kornel Korany
The volatile constituents of the fruiting bodies of 4 culinary-medicinal mushroom species (Agaricus bisporus, Boletus edulis, Cantharellus cibarius, and Hericium erinaceus) from Hungary were examined to review their aroma composition. Simultaneous distillation/extraction was applied to extract volatile compounds from fungi, and the values were measured with gas chromatography--mass spectrometry. Although the fragrances of fungi are not as characteristic as those of spices, several groups of volatile compounds have been found in mushrooms...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28686221/evaluation-of-cyanea-capillata-sting-management-protocols-using-ex-vivo-and-in-vitro-envenomation-models
#3
Thomas K Doyle, Jasmine L Headlam, Christie L Wilcox, Eoin MacLoughlin, Angel A Yanagihara
Lion's mane jellyfish (Cyanea capillata) stings cause severe pain and can lead to dangerous systemic effects, including Irukandji-like syndrome. As is the case for most cnidarian stings, recommended medical protocols in response to such stings lack rigorous scientific support. In this study, we sought to evaluate potential first aid care protocols using previously described envenomation models that allow for direct measurements of venom activity. We found that seawater rinsing, the most commonly recommended method of tentacle removal for this species, induced significant increases in venom delivery, while rinsing with vinegar or Sting No More(®) Spray did not...
July 7, 2017: Toxins
https://www.readbyqxmd.com/read/28087447/structures-biological-activities-and-industrial-applications-of-the-polysaccharides-from-hericium-erinaceus-lion-s-mane-mushroom-a-review
#4
REVIEW
Xirui He, Xiaoxiao Wang, Jiacheng Fang, Yu Chang, Ning Ning, Hao Guo, Linhong Huang, Xiaoqiang Huang, Zefeng Zhao
Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28070288/getting-to-the-core-internal-body-temperatures-help-reveal-the-ecological-function-and-thermal-implications-of-the-lions-mane
#5
Paul Trethowan, Andrea Fuller, Anna Haw, Tom Hart, Andrew Markham, Andrew Loveridge, Robyn Hetem, Byron du Preez, David W Macdonald
It has been proposed that there is a thermal cost of the mane to male lions, potentially leading to increased body surface temperatures (Ts), increased sperm abnormalities, and to lower food intake during hot summer months. To test whether a mane imposes thermal costs on males, we measured core body temperature (Tb) continuously for approximately 1 year in 18 free-living lions. There was no difference in the 24-hr maximum Tb of males (n = 12) and females (n = 6), and males had a 24-hr mean Tb that was 0...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/26853960/anti-gastric-ulcer-activity-of-polysaccharide-fraction-isolated-from-mycelium-culture-of-lion-s-mane-medicinal-mushroom-hericium-erinaceus-higher-basidiomycetes
#6
Mingxing Wang, Tetsuya Konishi, Yang Gao, Duoduo Xu, Qipin Gao
Hericium erinaceus is a culinary-medicinal mushroom that is used in traditional medicine, in folk medicine, and as medicinal cuisine in Asian countries such as China, Japan, and Korea. H. erinaceus exhibits various pharmacological properties, such as anti-cancer, immunomodulation, anti-dementia, and anti-gastric ulcer effects. The extracts of the fruiting body of H. erinaceus demonstrate anti-gastritis activity. However, the active principle in the extract, as well as the mechanism to treat gastric ulcers, remains uncertain...
2015: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/26853959/lion-s-mane-hericium-erinaceus-and-tiger-milk-lignosus-rhinocerotis-higher-basidiomycetes-medicinal-mushrooms-stimulate-neurite-outgrowth-in-dissociated-cells-of-brain-spinal-cord-and-retina-an-in-vitro-study
#7
Snehlata Samberkar, Sivasangkary Gandhi, Murali Naidu, Kah-Hui Wong, Jegadeesh Raman, Vikineswary Sabaratnam
Neurodegenerative disease is defined as a deterioration of the nervous system in the intellectual and cognitive capabilities. Statistics show that more than 80-90 million individuals age 65 and above in 2050 may be affected by neurodegenerative conditions like Alzheimer's and Parkinson's disease. Studies have shown that out of 2000 different types of edible and/or medicinal mushrooms, only a few countable mushrooms have been selected until now for neurohealth activity. Hericium erinaceus is one of the well-established medicinal mushrooms for neuronal health...
2015: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/26559695/the-anti-inflammatory-effects-of-lion-s-mane-culinary-medicinal-mushroom-hericium-erinaceus-higher-basidiomycetes-in-a-coculture-system-of-3t3-l1-adipocytes-and-raw264-macrophages
#8
Koichiro Mori, Kenji Ouchi, Noriyasu Hirasawa
Chronic low-grade inflammation in the adipose tissue accompanying obesity is thought to be an underlying driver of metabolic diseases. In this study, we aimed to investigate the efficacy of Hericium erinaceus on adipose tissue inflammation. The anti-inflammatory effects of the ethyl acetate soluble fraction of H. erinaceus (EAHE) were examined using cocultures of 3T3-L1 adipocytes and RAW264 macrophages. EAHE significantly suppressed tumor necrosis factor (TNF)-α and interleukin (IL)-6 production in cultured RAW264 macrophages stimulated by lipopolysaccharide (LPS)...
2015: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/26274992/endoscope-assisted-endonasal-versus-supraorbital-keyhole-resection-of-olfactory-groove-meningiomas-comparison-and-combination-of-2-minimally-invasive-approaches
#9
COMPARATIVE STUDY
Matei A Banu, Alpesh Mehta, Malte Ottenhausen, Justin F Fraser, Kunal S Patel, Oszkar Szentirmai, Vijay K Anand, Apostolos J Tsiouris, Theodore H Schwartz
OBJECTIVE: Although the endonasal endoscopic approach has been applied to remove olfactory groove meningiomas, controversy exists regarding the efficacy and safety of this approach compared with more traditional transcranial approaches. The endonasal endoscopic approach was compared with the supraorbital (eyebrow) keyhole technique, as well as a combined "above-and-below" approach, to evaluate the relative merits of each approach in different situations. METHODS: Nineteen cases were reviewed and divided according to operative technique into 3 different groups: purely endonasal (6 cases); supraorbital eyebrow (microscopic with endoscopic assistance; 7 cases); and combined endonasal endoscopic with either the bicoronal or eyebrow microscopic approach (6 cases)...
March 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/26244378/chemistry-nutrition-and-health-promoting-properties-of-hericium-erinaceus-lion-s-mane-mushroom-fruiting-bodies-and-mycelia-and-their-bioactive-compounds
#10
REVIEW
Mendel Friedman
The culinary and medicinal mushroom Hericium erinaceus is widely consumed in Asian countries, but apparently not in the United States, for its nutritional and health benefits. To stimulate broader interest in the reported beneficial properties, this overview surveys and consolidates the widely scattered literature on the chemistry (isolation and structural characterization) of polysaccharides and secondary metabolites such as erinacines, hericerins, hericenones, resorcinols, steroids, mono- and diterpenes, and volatile aroma compounds, nutritional composition, food and industrial uses, and exceptional nutritional and health-promoting aspects of H...
August 19, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25954906/systemic-screening-of-strains-of-the-lion-s-mane-medicinal-mushroom-hericium-erinaceus-higher-basidiomycetes-and-its-protective-effects-on-a%C3%AE-triggered-neurotoxicity-in-pc12-cells
#11
Zongying Liu, Qinglong Wang, Jian Cui, Lili Wang, Lili Xiong, Wei Wang, Diqiang Li, Na Liu, Yiran Wu, Canquan Mao
Hericium erinaceus possesses multiple medicinal values. To date, however, there have been few studies of the systemic screening of H. erinaceus strains, and the neuroprotective effects of H. erinaceus prepared from homogenized, fresh fruiting bodies are not fully understood. In this study, 4 random primers were selected and used in random amplified polymorphic DNA (RAPD) polymerase chain reaction (PCR) to screen and evaluate the genetic diversity of 19 commercial strains of H. erinaceus from different localities in China...
2015: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/25306354/isolation-and-identification-of-aromatic-compounds-in-lion-s-mane-mushroom-and-their-anticancer-activities
#12
Wei Li, Wei Zhou, Eun-Ji Kim, Sang Hee Shim, Hee Kyoung Kang, Young Ho Kim
Lion's Mane Mushroom (Hericium erinaceum) is a traditional edible mushroom widely used in culinary applications and as an herbal medicine in East Asian countries. In the present study, two new aromatic compounds, hericerin A (1) and isohericenone J (5), along with five known compounds, isoericerin (2), hericerin (3), N-De phenylethyl isohericerin (4), hericenone J (6), and 4-[3',7'-dimethyl-2',6'-octadienyl]-2-formyl-3-hydroxy-5-methyoxybenzylalcohol (7), were isolated from a methanol extract of the fruiting bodies of H...
March 1, 2015: Food Chemistry
https://www.readbyqxmd.com/read/24959591/inhibitory-effect-on-in-vitro-ldl-oxidation-and-hmg-co-a-reductase-activity-of-the-liquid-liquid-partitioned-fractions-of-hericium-erinaceus-bull-persoon-lion-s-mane-mushroom
#13
Mohammad Azizur Rahman, Noorlidah Abdullah, Norhaniza Aminudin
Oxidation of low-density lipoprotein (LDL) has been strongly suggested as the key factor in the pathogenesis of atherosclerosis. Mushrooms have been implicated in having preventive effects against chronic diseases due especially to their antioxidant properties. In this study, in vitro inhibitory effect of Hericium erinaceus on LDL oxidation and the activity of the cholesterol biosynthetic key enzyme, 3-hydroxy-3-methyl glutaryl coenzyme A (HMG Co-A) reductase, was evaluated using five liquid-liquid solvent fractions consisting of methanol : dichloromethane (M : DCM), hexane (HEX), dichloromethane (DCM), ethyl acetate (EA), and aqueous residue (AQ)...
2014: BioMed Research International
https://www.readbyqxmd.com/read/24506286/vitamin-b12-c-lactone-a-biologically-inactive-corrinoid-compound-occurs-in-cultured-and-dried-lion-s-mane-mushroom-hericium-erinaceus-fruiting-bodies
#14
Fei Teng, Tomohiro Bito, Shigeo Takenaka, Yukinori Yabuta, Fumio Watanabe
This study determined the vitamin B12 content of the edible medicinal mushroom Hericium erinaceus, lion's mane mushroom fruiting body, using a microbiological assay based on Lactobacillus delbrueckii ATCC 7830. Trace levels (0.04-0.36 μg/100 g dry weight) of vitamin B12 were found in most of the dried mushroom samples, and two samples contained slightly higher levels (0.56 and 1.04 μg/100 g dry weight, respectively) of vitamin B12. We purified the corrinoid compounds from the extracts of dried lion's mane mushroom fruiting bodies using an immunoaffinity column and identified them as vitamin B12 or vitamin B12[c-lactone] (or both) based on LC/ESI-MS/MS chromatograms...
February 19, 2014: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/24329027/the-lion-s-mane-sign-surgical-results-using-the-bilateral-fronto-orbito-nasal-approach-in-large-and-giant-anterior-skull-base-meningiomas
#15
Maria S Li, Sandra Miller Portman, Akram Rahal, Gérard Mohr, Vijayabalan Balasingam
OBJECT: Concerns about extreme peritumoral edema and its ensuing surgical and perioperative complications led the authors to use the bilateral fronto-orbito-nasal approach to remove midline anterior skull base meningiomas that were larger than 4 cm. The authors hypothesize that extreme vasogenic edema exemplified by finger-like hyperintensities extending into the bifrontal white matter and external capsule and/or the extreme capsule, coined the lion's mane sign (LMS), would help identify patients with a challenging postoperative course...
February 2014: Journal of Neurosurgery
https://www.readbyqxmd.com/read/24302966/gastroprotective-effects-of-lion-s-mane-mushroom-hericium-erinaceus-bull-fr-pers-aphyllophoromycetideae-extract-against-ethanol-induced-ulcer-in-rats
#16
Jing-Yang Wong, Mahmood Ameen Abdulla, Jegadeesh Raman, Chia-Wei Phan, Umah Rani Kuppusamy, Shahram Golbabapour, Vikineswary Sabaratnam
Hericium erinaceus is a famous tonic in oriental medicine. The gastroprotective effects of aqueous extract of H. erinaceus against ethanol-induced ulcers in Sprague Dawley rats were investigated. The possible involvements of lipid peroxidation, superoxide dismutase, and catalase were also investigated. Acute toxicity study was performed. The effects of aqueous extract of H. erinaceus on the ulcer areas, ulcer inhibition, gastric wall mucus, gross and histological gastric lesions, antioxidant levels, and malondialdehyde (MDA) contents were evaluated in ethanol-induced ulcer in vivo...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/24266378/neurotrophic-properties-of-the-lion-s-mane-medicinal-mushroom-hericium-erinaceus-higher-basidiomycetes-from-malaysia
#17
Puei-Lene Lai, Murali Naidu, Vikineswary Sabaratnam, Kah-Hui Wong, Rosie Pamela David, Umah Rani Kuppusamy, Noorlidah Abdullah, Sri Nurestri A Malek
Neurotrophic factors are important in promoting the growth and differentiation of neurons. Nerve growth factor (NGF) is essential for the maintenance of the basal forebrain cholinergic system. Hericenones and erinacines isolated from the medicinal mushroom Hericium erinaceus can induce NGF synthesis in nerve cells. In this study, we evaluated the synergistic interaction between H. erinaceus aqueous extract and exogenous NGF on the neurite outgrowth stimulation of neuroblastoma-glioma cell NG108-15. The neuroprotective effect of the mushroom extract toward oxidative stress was also studied...
2013: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/23872357/sperm-quality-and-the-morphology-of-cryopreserved-testicular-tissues-recovered-post-mortem-from-diverse-wild-species
#18
Paweena Thuwanut, Sayamon Srisuwatanasagul, Grisnarong Wongbandue, Nae Tanpradit, Ampika Thongpakdee, Daraka Tongthainan, Sukanya Manee-In, Kaywalee Chatdarong
This study compared the effects of slow and fast freezing of testicular tissue of wild animals collected at post-mortem on testicular structure and testicular sperm. The testes of seven animals that had died in captivity; three felids (jungle cat, lion and leopard), two cervids (rusa deer and fea's muntjac) and two bovids (Sumatran serows) were cryopreserved using slow- and fast-freezing protocols. There were greater reductions in the integrity of the sperm membrane and DNA in tissues cryopreserved using slow freezing compared to fast freezing (membrane integrity reduced by 21...
October 2013: Cryobiology
https://www.readbyqxmd.com/read/23735479/hericium-erinaceus-an-edible-mushroom-with-medicinal-values
#19
REVIEW
Md Asaduzzaman Khan, Mousumi Tania, Rui Liu, Mohammad Mijanur Rahman
Mushrooms are considered as nutritionally functional foods and source of physiologically beneficial medicines. Hericium erinaceus, also known as Lion's Mane Mushroom or Hedgehog Mushroom, is an edible fungus, which has a long history of usage in traditional Chinese medicine. This mushroom is rich in some physiologically important components, especially β-glucan polysaccharides, which are responsible for anti-cancer, immuno-modulating, hypolipidemic, antioxidant and neuro-protective activities of this mushroom...
May 24, 2013: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/23668749/hericium-erinaceus-lion-s-mane-mushroom-extracts-inhibit-metastasis-of-cancer-cells-to-the-lung-in-ct-26-colon-cancer-tansplanted-mice
#20
Sung Phil Kim, Seok Hyun Nam, Mendel Friedman
This study investigated the antimetastatic activity of four Hericium erinaceus edible mushroom extracts using CT-26 murine colon carcinoma cells as an indicator of inhibition of cell migration to the lung. Hot water (HWE) and microwaved 50% ethanol (MWE) extracts of H. erinaceus strongly elicited cancer cell death through apoptosis and inhibited metastasis of cancer cells to the lungs by 66% and 69%, respectively. HWE and MWE reduced the expression of matrix metalloproteinases MMP-2 and MMP-9 in cells and their activities in culture media...
May 22, 2013: Journal of Agricultural and Food Chemistry
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