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preterm labor risk

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https://www.readbyqxmd.com/read/29673669/rupture-of-the-scarred-and-unscarred-gravid-uterus-outcomes-and-risk-factors-analysis
#1
Shu-Han You, Yao-Lung Chang, Chih-Feng Yen
OBJECTIVE: To study the maternal and fetal outcomes and assess the risk factors in patients with rupture at the lower-segment or non-lower-segment scarred, or unscarred gravid uterus. MATERIALS AND METHODS: Gravid patients with uterine rupture were retrospectively collected in Chang-Gung Memorial Hospital from November 2004 to July 2017. The rupture timing and location in association with maternal and fetal outcomes were collected as well as the possible risk factors including surgical history and interval prior to conception were analyzed...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29670470/maternal-plasma-metabolomic-profiles-in-spontaneous-preterm-birth-preliminary-results
#2
Barbara Lizewska, Joanna Teul, Pawel Kuc, Adam Lemancewicz, Karol Charkiewicz, Joanna Goscik, Marian Kacerovsky, Ramkumar Menon, Wojciech Miltyk, Piotr Laudanski
Objective: To profile maternal plasma metabolome in spontaneous preterm birth. Method: In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy ( n = 57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy ( n = 49)), and with term delivery ( n = 25). Plasma samples were analysed using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) in positive and negative polarity modes...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29670041/comparative-evaluation-of-arabin-pessary-and-cervical-cerclage-for-the-prevention-of-preterm-labor-in-asymptomatic-women-with-high-risk-factors
#3
Panagiotis Tsikouras, George Anastasopoulos, Vasileios Maroulis, Anastasia Bothou, Anna Chalkidou, Dorelia Deuteraiou, Xanthoula Anthoulaki, Georgios Tsatsaris, Arzou Halil Bourazan, George Iatrakis, Stefanos Zervoudis, Georgios Galazios, Lola-Katerina Inagamova, Roland Csorba, Alexander-Tobias Teichmann
OBJECTIVE: Preterm labor is one of the most significant obstetric problems associated with high rate of actual and long-term perinatal complications. Despite the creation of scoring systems, uterine activity monitoring, cervical ultrasound and several biochemical markers, the prediction and prevention of preterm labor is still a matter of concern. The aim of this study was to examine cervical findings for the prediction and the comparative use of Arabin pessary or cerclage for the prevention of preterm birth in asymptomatic women with high risk factors for preterm labor...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29668583/a-prisma-systematic-review-and-meta-analysis-on-chlamydia-trachomatis-infections-in-iranian-women-1986-2015
#4
Daem Roshani, Rashid Ramazanzadeh, Fariba Farhadifar, Amjad Ahmadi, Safoura Derakhshan, Samaneh Rouhi, Shamsi Zarea, Farnaz Zandvakili
BACKGROUND: Chlamydia trachomatis (CT) is the cause of genital tract infections in women. Some evidence has shown the role of this infection with CT in spontaneous abortions. The purpose of this study is to study the frequency of CT infection in Iranian women. METHODS: This study was performed based on PRISMA guidelines. A total of 75 articles published in Google Scholar, PubMed, ISI Web of Science, Biological abs, Iranmedex, SID, and Scopus databases were found (1986-2015) using the following keywords: CT in women, CT and Iranian women, CT and infection in Iran, CT and pregnancy in Iran, CT and preterm delivery in Iran, CT and preterm labor in Iran, CT and fertility in Iran, CT and infertility in Iran, and CT and abortion in Iran...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29660361/maternal-and-fetal-outcome-after-cardiac-surgery-during-pregnancy-a-meta-analysis
#5
REVIEW
Nivedita Jha, Ajay Kumar Jha, Ramesh Chand Chauhan, Neelima Singh Chauhan
BACKGROUND: In the past, cardiac surgery during pregnancy has been associated with high risk of adverse maternal and fetal outcomes. Therefore, this meta-analysis was done to assess the fetomaternal risk after cardiac surgery during pregnancy using cardiopulmonary bypass in more recent studies. METHODS: The Medline, Embase and Cochrane library were searched to find studies from January 1 1990 to July 31 2016 without language restriction. We selected studies that included at least four women to report fetomaternal outcomes after cardiac surgery using cardiopulmonary bypass during pregnancy...
April 13, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29658448/-clinical-features-and-prognosis-of-preterm-infants-with-varying-degrees-of-bronchopulmonary-dysplasia
#6
Wen-Li Li, Fa-Lin Xu, Ming Niu, Meng-Di Liu, Hui-Fang Dong
OBJECTIVE: To study the clinical features and prognosis of preterm infants with varying degrees of bronchopulmonary dysplasia (BPD). METHODS: The clinical data of 144 preterm infants with a gestational age of <32 weeks who were admitted to the neonatal intensive care unit from March 2014 to March 2016 and were diagnosed with BPD were collected. According to the severity of BPD, these preterm infants were divided into mild group with 81 infants and moderate/severe group with 63 infants...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29642747/elevated-maternal-serum-free-%C3%AE-human-chorionic-gonadotropin-%C3%AE-hcg-and-reduced-risk-of-spontaneous-preterm-delivery
#7
Shelly Soni, David A Krantz, Matthew J Blitz, Nidhi Vohra, Burton Rochelson
OBJECTIVE: To evaluate the relationship between first and second trimester maternal serum-free β-hCG and the risk of spontaneous preterm delivery (PTD). STUDY DESIGN: This was a case-control study of women evaluated and delivered at our institution from 2011 to 2015. Spontaneous PTD was defined as delivery before 37 weeks due to spontaneous preterm labor or premature rupture of membranes. Patient with multifetal gestation and those with medically indicated term or PTD were excluded...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29626275/antenatal-management-for-women-with-inflammatory-bowel-disease-experience-from-our-ibd-mom-clinic
#8
Ariella Bar-Gil Shitrit, Yael Cohen, Ori Hassin, Ami Ben Ya'acov, Rivkah Farkash, Benjamin Koslowsky, Yael Milgrom, Dan Meir Livovsky, Arnon Samueloff, Eran Goldin, Sorina Grisaru-Granovsky
BACKGROUND: Inflammatory bowel disease affects women during their reproductive years and thus pregnancy outcomes. IBD MOM is a multidisciplinary, single-center clinic established to benefit women with IBD and their neonates. AIM: The aim of this study was to evaluate the perinatal outcomes of the IBD MOM clinic patients compared to patients who attended antenatal and gastrointestinal disease community clinics (IBD CC). METHODS: This single-center, prospective study was conducted from 2011 to 2015...
April 6, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29609190/stillbirth-inflammatory-markers-and-obesity-results-from-the-stillbirth-collaborative-research-network
#9
Margo S Harrison, Vanessa R Thorsten, Donald J Dudley, Corette B Parker, Matthew A Koch, Carol J R Hogue, Barbara J Stoll, Robert M Silver, Michael W Varner, M Halit Pinar, Donald R Coustan, George R Saade, Radek K Bukowski, Deborah L Conway, Marian Willinger, Uma M Reddy, Robert L Goldenberg
BACKGROUND:  Obesity is associated with increased risk of stillbirth, although the mechanisms are unknown. Obesity is also associated with inflammation. Serum ferritin, C-reactive protein, white blood cell count, and histologic chorioamnionitis are all markers of inflammation. OBJECTIVE:  This article determines if inflammatory markers are associated with stillbirth and body mass index (BMI). Additionally, we determined whether inflammatory markers help to explain the known relationship between obesity and stillbirth...
April 2, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29607580/effectiveness-of-antenatal-perineal-massage-in-reducing-perineal-trauma-and-post-partum-morbidities-a-randomized-controlled-trial
#10
Emmanuel Onyebuchi Ugwu, Eric Sunday Iferikigwe, Samuel Nnamdi Obi, George Uchenna Eleje, Benjamin Chukwuma Ozumba
AIM: The study aimed to evaluate the effectiveness of antenatal perineal massage (APM) in reducing perineal trauma and post-partum morbidities. METHODS: A randomized controlled trial of 108 primigravidae at the University of Nigeria Teaching Hospital, Enugu, Nigeria, was conducted from January 2013 to May 2014. The intervention group received APM, while the control group did not receive APM. RESULTS: Women who received APM were significantly more likely to have an intact perineum after childbirth [27/53 (50...
April 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29577271/anatomic-relationship-of-internal-cervical-os-to-maternal-bladder-in-pregnancies-at-low-and-high-risk-of-preterm-delivery
#11
Daniel Faustin, Sabia Akbar, Tatiana Bihun, Erica Gomez, Derek Liang, Petr Itzhak, Ralph Ruggiero, Joylin Devadoss
Preterm delivery correlates with perinatal death and long-term neurologic sequelae in surviving newborns.1,3 Cervical changes demonstrated by transvaginal sonogram can help to predict preterm labor.3,4 Shalev et al.4 have reported on the position of the internal cervical os relative to the maternal bladder in prediction of preterm delivery. We did the present retrospective study to test the hypothesis that women at risk of preterm delivery are more likely to display a low-set internal cervical os than are those at low risk of preterm labor and delivery...
March 25, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29574853/prevalence-and-predictive-factors-of-early-postpartum-diabetes-among-women-with-gestational-diabetes-in-a-single-center-cohort
#12
Ankia Coetzee, Deidre Mason, David R Hall, Magda Conradie
OBJECTIVE: To determine the prevalence of diabetes at 6-12 weeks postpartum among women with gestational diabetes mellitus (GDM), and to identify prenatal postpartum diabetes predictors. METHODS: In the present prospective cohort study, glucose statuses of consecutive women newly diagnosed with hyperglycemia during pregnancy were evaluated at 6-12 weeks postpartum between November 1, 2015, and November 1, 2016, at Tygerberg Hospital, Cape Town, South Africa. Women with known diabetes were excluded...
March 25, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29573249/the-risk-of-spontaneous-preterm-birth-according-to-maternal-pre-pregnancy-body-mass-index-in-twin-gestations
#13
Su Jin Sung, Seung Mi Lee, Sunmin Kim, Byoung Jae Kim, Chan Wook Park, Joong Shin Park, Jong Kwan Jun
BACKGROUND: Maternal obesity is a well-known risk factor for both total preterm birth (PTB) and spontaneous PTB in singleton gestation, whereas this association is not well determined in multiple pregnancy. The objective of this study was to determine the risk of spontaneous PTB according to the pre-pregnancy body mass index (BMI) in twin gestations. METHODS: The association between the risk of PTB and pre-pregnancy BMI was determined in women pregnant with twins between 2004 and 2014...
March 26, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29565684/progestogens-and-pregnancy-loss
#14
H J A Carp
Progestational agents are often prescribed to prevent pregnancy loss. Progestogens affect implantation, cytokine balance, natural killer cell activity, arachidonic acid release and myometrial contractility. Progestogens have therefore been used at all stages of pregnancy including luteal-phase support prior to pregnancy, threatened miscarriage, recurrent miscarriage, and to prevent preterm labor. In luteal support, a Cochrane review reported that progestogens were associated with a higher rate of live births or ongoing pregnancy in the progesterone group (odds ratio 1...
March 22, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29543532/crh-crhr1-mediates-prenatal-synthetic-glucocorticoid-programming-of-depression-like-behavior-across-2-generations
#15
Yong-Jun Xu, Hui Sheng, Tian-Wen Wu, Qing-Yue Bao, You Zheng, Yan-Min Zhang, Yu-Xiang Gong, Jian-Qiang Lu, Zhen-Dong You, Yang Xia, Xin Ni
Pregnant women at risk of preterm labor usually receive synthetic glucocorticoids (sGCs) to promote fetal lung development. Emerging evidence indicates that antenatal sGC increases the risk of affective disorders in offspring. Data from animal studies show that such disorders can be transmitted to the second generation. However, the molecular mechanisms underlying the intergenerational effects of prenatal sGC remain largely unknown. Here we show that prenatal dexamethasone (Dex) administration in late pregnancy induced depression-like behavior in first-generation (F1) offspring, which could be transmitted to second-generation (F2) offspring with maternal dependence...
March 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29534760/temporal-trends-of-preterm-birth-in-shenzhen-china-a-retrospective-study
#16
Changchang Li, Zhijiang Liang, Michael S Bloom, Qiong Wang, Xiaoting Shen, Huanhuan Zhang, Suhan Wang, Weiqing Chen, Yan Lin, Qingguo Zhao, Cunrui Huang
BACKGROUND: Preterm birth is the leading cause of child mortality under 5 years of age. Temporal trends in preterm birth rates are highly heterogeneous among countries and little information exists for China. To address this data gap, we investigated annual changes in preterm birth incidence rate and explored potential determinants of these changes in Shenzhen, China. METHODS: A total of 1.4 million live births, during 2003-2012, were included from the Shenzhen birth registry...
March 13, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29531735/portal-vein-thrombosis-after-cesarean-section-in-a-patient-on-prolonged-bed-rest-due-to-threatened-preterm-labor
#17
Arata Hibi, Kazumasa Mogi
Portal vein thrombosis is a rare but life-threatening complication during pregnancy and postpartum period. Color Doppler ultrasound is useful for prompt diagnosis. Although the risk of complications should be considered, successful pregnancy with comorbid portal vein thrombosis is possible with appropriate anticoagulation therapy and close monitoring.
March 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29527406/a-retrospective-database-analysis-of-neonatal-morbidities-to-evaluate-a-composite-endpoint-for-use-in-preterm-labor-clinical-trials
#18
Jeanne M Pimenta, Myla Ebeling, Timothy H Montague, Kathleen J Beach, Jill Abell, Michael T O'Shea, Marcy Powell, Thomas C Hulsey
Objective  To propose and assess a composite endpoint (CE) of neonatal benefit based on neonatal mortality and morbidities by gestational age (GA) for use in preterm labor clinical trials. Study Design  A descriptive, retrospective analysis of the Medical University of South Carolina Perinatal Information System database was conducted. Neonatal morbidities were assessed for inclusion in the CE based on clinical significance/risk of childhood neurodevelopmental impairment, frequency, and association with GA in a mother-neonate linked cohort, comprising women with uncomplicated singleton pregnancies delivered at ≥24 weeks' GA...
January 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29524791/polybacterial-stimulation-suggests-discrete-il-6-il-6r-signaling-in-human-fetal-membranes-potential-implications-on-il-6-bioactivity
#19
Nathalia Mayumi Noda-Nicolau, Jossimara Polettini, Márcia Guimarães da Silva, Morgan R Peltier, Ramkumar Menon
The polybacterial invasion of the amniotic cavity and risk of preterm birth is often due to cervicovaginal bacteria such as genital mycoplasmas (Mycoplasma hominis and Ureaplasma urealyticum) and Gardnerella vaginalis. The most studied biomarker associated with preterm birth is interleukin-6 (IL-6), a pleiotropic cytokine that performs different functions based on classical or trans-signaling mechanisms. This study evaluated the changes in IL-6 and IL-6 function associated accessory molecules by human fetal membranes to determine the functional availability of IL-6 assessment in an in vitro model of polybacterial infection...
March 2, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29524569/developmental-neurotoxicity-resulting-from-pharmacotherapy-of-preterm-labor-modeled-in-vitro-terbutaline-and-dexamethasone-separately-and-together
#20
Theodore A Slotkin, Samantha Skavicus, Frederic J Seidler
Terbutaline and dexamethasone are used in the management of preterm labor, often for durations of treatment exceeding those recommended, and both have been implicated in increased risk of neurodevelopmental disorders. We used a variety of cell models to establish the critical stages at which neurodifferentiation is vulnerable to these agents and to determine whether combined exposures produce a worsened outcome. Terbutaline selectively promoted the initial emergence of glia from embryonic neural stem cells (NSCs)...
March 7, 2018: Toxicology
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