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https://www.readbyqxmd.com/read/28098674/diethylstilbestrol-potential-health-risks-for-women-exposed-in-utero-and-their-offspring
#1
J Leocadia Conlon
Diethylstilbestrol (DES) is a synthetic estrogen given to pregnant women to prevent miscarriages and preterm labor; the drug was used between 1941 and 1971 in the United States and into the 1980s in other countries. DES exposure is associated with significant long-term health effects, including increased risk for breast cancer, cervical and vaginal clear cell adenocarcinoma, reproductive tract abnormalities, infertility, poor pregnancy outcomes, and early menopause. This article reviews the potential health risks associated with DES exposure, how to assess which patients are at risk, and management recommendations for patients exposed to DES...
February 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28094234/association-between-preterm-labor-and-genitourinary-tract-infections-caused-by-trichomonas-vaginalis-mycoplasma-hominis-gram-negative-bacilli-and-coryneforms
#2
Alaa El-Dien M S Hosny, Waleed El-Khayat, Mona T Kashef, Mohsen N Fakhry
BACKGROUND: Preterm labor (PTL) is responsible for most cases of neonatal death. In most of these cases, the causes of PTL have not been established although several risk factors have been described. Therefore, the aim of this study was to investigate risk factors for PTL before 37 gestational weeks among Egyptian women. METHODS: In this case-control study, 117 pregnant women without risk factors for PTL were chosen. The control group (n=45) had term labor (gestational weeks≥37 weeks), and the case group (n=72) had PTL (gestational weeks < 37 weeks)...
January 13, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28068594/prevention-of-spontaneous-preterm-birth-guidelines-for-clinical-practice-from-the-french-college-of-gynaecologists-and-obstetricians-cngof
#3
REVIEW
Loïc Sentilhes, Marie-Victoire Sénat, Pierre-Yves Ancel, Elie Azria, Guillaume Benoist, Julie Blanc, Gilles Brabant, Florence Bretelle, Stéphanie Brun, Muriel Doret, Chantal Ducroux-Schouwey, Anne Evrard, Gilles Kayem, Emeline Maisonneuve, Louis Marcellin, Stéphane Marret, Nicolas Mottet, Sabine Paysant, Didier Riethmuller, Patrick Rozenberg, Thomas Schmitz, Héloïse Torchin, Bruno Langer
In France, 60,000 neonates are born preterm every year (7.4%), half of them after the spontaneous onset of labor. Among preventable risk factors of spontaneous prematurity, only cessation of smoking is associated with decreased prematurity (level of evidence [LE]1). It is therefore recommended (Grade A). Routine screening and treatment of vaginal bacteriosis is not recommended in the general population (Grade A). The only population for which vaginal progesterone is recommended is that comprising asymptomatic women with singleton pregnancies, no history of preterm delivery, and a short cervix at 16-24 weeks of gestation (Grade B)...
December 30, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28063263/three-dimensional-ultrasound-first-trimester-fetal-volume-measurement-and-its-relation-to-pregnancy-outcome
#4
Haitham A Torky, Asem A Moussa, Ali M Ahmad, Osama Dief, Manar A Eldesoouky, Ahmed S El-Gayed
AIM OF WORK: To determine whether fetal volume (FV) measured by three-dimensional (3D) ultrasound was able to detect fetuses at risk of low birth weight (primary outcome) and/or preterm labor (secondary outcome). METHODS: One hundred pregnant women carrying a singleton living pregnancy who were sure of dates, and had a dating scan, with gestational age between 11 weeks and 13 weeks+6 days coming for routine first trimester nuchal translucency (NT) were examined by both two-dimensional (2D) and 3D ultrasound (Vocal System) for crown-rump length (CRL) and FV then followed up regularly every 4 weeks until 28 weeks then biweekly until 36 weeks then weekly until delivery both clinically and by ultrasound biometry...
January 7, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28052083/pregnancy-outcomes-after-treatment-for-cervical-cancer-precursor-lesions-an-observational-study
#5
Sheila Weinmann, Allison Naleway, Geeta Swamy, Girishanthy Krishnarajah, Bhakti Arondekar, Jovelle Fernandez, Evan Myers
OBJECTIVE: To examine whether surgical procedures involving the uterine cervix were associated with pregnancy outcomes, including preterm birth, low birth weight, cesarean delivery and pregnancy loss. DESIGN: Population-based observational study nested in retrospective matched cohort. SETTING: Kaiser Permanente Northwest integrated health plan in Oregon/Washington, U.S.A. POPULATION: Female health plan members age 14-53 years with documented pregnancies from 1998-2009...
2017: PloS One
https://www.readbyqxmd.com/read/28034657/failure-of-physiologic-transformation-of-spiral-arteries-endothelial-and-trophoblast-cell-activation-and-acute-atherosis-in-the-basal-plate-of-the-placenta
#6
Carlos A Labarrere, Hector L Dicarlo, Elaine Bammerlin, James W Hardin, Yeon M Kim, Piya Chaemsaithong, David M Haas, Ghassan S Kassab, Roberto Romero
BACKGROUND: Failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous preterm labor with intact or ruptured membranes. Spiral arteries with failure of physiologic transformation are prone to develop atherosclerotic-like lesions of atherosis. There are striking parallels between preeclampsia and atherosclerotic disease, and between lesions of atherosis and atherosclerosis. Endothelial activation, identified by intercellular adhesion molecule-1 (ICAM-1) expression, is present in atherosclerotic-like lesions of heart transplantation, and is considered a manifestation of rejection...
December 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28029462/-prediction-of-preterm-delivery-in-symptomatic-women-preterm-labor
#7
G Benoist
OBJECTIVES: To evaluate the predictors of spontaneous preterm birth in case of preterm labor. MATERIALS AND METHODS: Literature search in Medline and Cochrane databases and recommendations of international societies. Selection of studies in symptomatic women (with preterm labor). RESULTS: Preterm labor is defined as a clinical situation occurring between 22 and 36 weeks + 6 days, in which cervical changes are observed associated with uterine contractions, evolving spontaneously or not to preterm delivery (Professional consensus)...
October 28, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/28009330/failure-to-initiate-breastfeeding-among-high-risk-obstetrical-patients-who-intended-to-breastfeed
#8
L Cordero, R Oza-Frank, M Moore-Clingenpeel, M B Landon, C A Nankervis
BACKGROUND: In the US, at the time of discharge from the hospital, 79% of women had initiated breastfeeding. Intention to breastfeed is a strong predictor of breastfeeding initiation; however, we reported initiation failure in 45% of women with pregestational diabetes who intended to breastfeed. Information regarding intention and initiation among women with other high risk obstetrical conditions (HROB) remains scarce. OBJECTIVE: To ascertain demographic and clinical factors associated with breastfeeding initiation failure among women with HROB conditions who intended to breastfeed...
2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27997053/cervical-length-screening-for-prevention-of-preterm-birth-in-singleton-pregnancies-with-threatened-preterm-labor-a-cochrane-systematic-review-and-meta-analysis-of-randomized-controlled-trials-using-individual-patient-level-data
#9
REVIEW
Vincenzo Berghella, Montse Palacio, Amen Ness, Zarko Alfirevic, Kypros Nicolaides, Gabriele Saccone
OBJECTIVE: Cervical length screening by transvaginal ultrasound has been shown to be a good predictive test for spontaneous preterm birth (PTB) in symptomatic singleton pregnancies with threatened preterm labor (PTL). The aim of this Cochrane review and meta-analysis of individual participant data was to evaluate the effect of using knowledge of transvaginal ultrasound cervical length (TVU CL) in preventing PTB in singleton pregnancies presenting with threatened PTL. METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register and the Cochrane Complementary Medicine Field's Trials Register (May 2016) and reference lists of retrieved studies...
December 20, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27990085/the-association-between-level-of-maternal-serum-leptin-in-the-third-trimester-and-the-occurrence-of-moderate-preterm-labor
#10
Fereshteh Fakor, Seyedeh Hajar Sharami, Forozan Milani, Fariba Mirblouk, Sodabeh Kazemi, Davoud Pourmarzi, Hannan Ebrahimi, Seyedeh Fatemeh Dalil Heirati
OBJECTIVE: We aimed to investigate the relationship between the level of maternal serum leptin and the occurrence of moderate preterm labor. MATERIAL AND METHODS: This was a case control study conducted on pregnant women referred to Al-Zahra Hospital in Rasht, north of Iran in 2013. Cases included 30 moderate preterm delivering women and 30 control pregnant women with the same gestational age. The maternal serum leptin was measured for each mother at the time of entering the study...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27926659/macroprolactinomas-and-nonfunctioning-pituitary-adenomas-and-pregnancy-outcomes
#11
Kimberley Lambert, Kate Rees, Paul T Seed, Mandish K Dhanjal, Marian Knight, David R McCance, Catherine Williamson
OBJECTIVE: To examine the monitoring, management, and outcomes of pituitary tumors in pregnancy. METHODS: A national, prospective, observational, population-based case series study was conducted in all U.K. consultant-led obstetric units over 3 years using the U.K. Obstetric Surveillance System. To evaluate rates of adverse pregnancy outcomes, women with a macroprolactinoma (10 mm or greater) or nonfunctioning pituitary adenoma, diagnosed before or during pregnancy, were compared with two comparison groups: 1) a U...
January 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27925622/relation-between-amniotic-fluid-infection-or-cytokine-levels-and-hearing-screen-failure-in-infants-at-32-wk-gestation-or-less
#12
Eun Young Jung, Byung Yoon Choi, Jihye Rhee, Jaehong Park, Soo-Hyun Cho, Kyo Hoon Park
BACKGROUND: To determine whether the presence of intra-amniotic infection and elevated proinflammatory cytokine levels in amniotic fluid (AF) are associated with failure in the newborn hearing screen (NHS) test in very preterm neonates. METHODS: This is a retrospective cohort study of 112 premature singleton neonates born to women with preterm labor or preterm premature rupture of membranes at ≤32 wk. AF obtained through amniocentesis was cultured, and interleukin-6 (IL-6) and IL-8 levels were determined...
December 7, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27903080/inter-pregnancy-interval-and-adverse-outcomes-evidence-for-an-additional-risk-in-health-disparate-populations
#13
Shyama Appareddy, Jason Pryor, Beth Bailey
OBJECTIVE: Short interpregnancy interval (IPI), <18 months between pregnancies, is a potential cause of adverse delivery and birth outcomes, and may be a particular issue among those with other risks. Our goal was to examine IPI and delivery/infant complications in Tennessee. METHODS: Birth certificate/vital records data included 101,912 women with a previous delivery. IPI groups (<6, 6-12, 12-18, 18-60 months) were compared on outcomes. RESULTS: Thirty-nine percent of the deliveries had IPI <18 months, 9% were <6 months, rates 11% and 27% higher than nationally...
December 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27896247/uterine-rupture-in-pregnancies-following-myomectomy-a-multicenter-case-series
#14
Hee-Sun Kim, Soo-Young Oh, Suk-Joo Choi, Hyun-Soo Park, Geum-Joon Cho, Jin-Hoon Chung, Yong-Soo Seo, Sun-Young Jung, Jung-Eun Kim, Su-Hyun Chae, Han-Sung Hwang
OBJECTIVE: The purpose of this case series was to retrospectively examine records of cases with uterine rupture in pregnancies following myomectomy and to describe the clinical features and pregnancy outcomes. METHODS: This study was conducted as a multicenter case series. The patient databases at 7 tertiary hospitals were queried. Records of patients with a diagnosis of uterine rupture in the pregnancy following myomectomy between January 2012 and December 2014 were retrospectively collected...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27895514/success-rate-in-preterm-uterine-contraction-inhibition-with-tocolytic-agents-in-a-tertiary-care-center
#15
Duangsamorn Kiatsuda, Jadsada Thinkhamrop, Witoon Prasertcharoensuk
OBJECTIVE: This study aims to assess the success rate of inhibiting preterm uterine contraction with tocolytic agents to delay delivery for at least 48 hours and risk factors of failure inhibition. MATERIALS AND METHODS: Between January 2013 and July 2014, medical records of all singleton pregnant women between 24 (0/7) and 33 (6/7) weeks of gestation with the diagnosis of preterm labor (with cervical dilatation) or threatened preterm labor (without cervical dilatation) who received tocolytic agents were reviewed...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27885286/immediate-outcome-of-hypoxic-ischaemic-encephalopathy-in-hypoxiate-newborns-in-nepal-medical-college
#16
S Shrestha, G S Shrestha, A Sharma
BACKGROUND: Birth asphyxia is the fifth major cause of under-five child deaths after pneumonia, diarrhoea, neonatal infections and complications of preterm birth. It is one of the important causes of neonatal mortality and morbidity accounting up to 30% of neonatal death in Nepal. It is also an important cause of long-term neurological disability and impairment. The mortality rate due to birth asphyxia is considered a good guide to the quality of perinatal care. This study was conducted to assess the rate of birth asphyxia, risk factors and outcome of the babies who were asphyxiated at birth...
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27879326/effects-of-levothyroxine-treatment-on-pregnancy-outcomes-in-pregnant-women-with-autoimmune-thyroid-disease
#17
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Maryam Tohidi, Hamid Alavi Majd, Fereidoun Azizi
BACKGROUND: Despite some studies indicating that thyroid antibody positivity during pregnancy has been associated with adverse pregnancy outcomes, evidence regarding the effects of levothyroxine (LT4) treatment of euthyroid/subclinical hypothyroid pregnant women with autoimmune thyroid disease on pregnancy outcome is limited. We aimed to assess whether pregnant women with autoimmune thyroid disease, but without overt thyroid dysfunction are affected by higher rates of adverse pregnancy outcomes...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27872420/role-of-cervical-length-measurement-for-preterm-delivery-prediction-in-women-with-threatened-preterm-labor-and-cervical-dilatation
#18
Liran Hiersch, Nir Melamed, Amir Aviram, Ron Bardin, Yariv Yogev, Eran Ashwal
OBJECTIVES: To compare the accuracy and cutoff points for cervical length for predicting preterm delivery in women with threatened preterm labor between those with a closed cervix and cervical dilatation. METHODS: We conducted a retrospective cohort study of women with singleton pregnancies with threatened preterm labor before 34 weeks. The accuracy of cervical length for predicting preterm delivery was compared between women with cervical dilatation (0.5-3 cm) and those with a closed cervix...
December 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27870810/neonatal-group-b-streptococcus-infections-prevention-strategies-clinical-and-microbiologic-characteristics-in-7-years-of-surveillance
#19
Roberta Creti, Monica Imperi, Alberto Berardi, Marco Pataracchia, Simona Recchia, Giovanna Alfarone, Lucilla Baldassarri
BACKGROUND: The characteristics of group B streptococcus (GBS) neonatal disease in a period of 7 years are reported. METHODS: The estimation of the neonatal GBS disease risk and prevention strategies adopted at delivery in absence of national guidelines were evaluated by the analysis of 3501 questionnaires. Notification of 194 neonatal GBS infections was recorded. In addition, 115 strains from neonatal early and late onset disease (EOD and LOD, respectively) plus 320 strains from pregnant women were analyzed by molecular typing methods and for antibiotic resistance...
November 18, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27865977/racial-ethnic-differences-in-preterm-perinatal-outcomes
#20
Maeve E Wallace, Pauline Mendola, Sung Soo Kim, Nikira Epps, Zhen Chen, Melissa Smarr, Stefanie N Hinkle, Yeyi Zhu, Katherine L Grantz
BACKGROUND: Racial disparities in preterm birth and infant death have been well documented. Less is known about racial disparities in neonatal morbidities among infants who are born at <37 weeks of gestation. OBJECTIVE: The purpose of this study was to determine whether the risk for morbidity and death among infants who are born preterm differs by maternal race. STUDY DESIGN: A retrospective cohort design included medical records from preterm deliveries of 19,325 black, Hispanic, and white women in the Consortium on Safe Labor...
November 16, 2016: American Journal of Obstetrics and Gynecology
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