Michie Imamura, Akihiro Mukaino, Koutaro Takamatsu, Hiroto Tsuboi, Osamu Higuchi, Hideki Nakamura, Saori Abe, Yukio Ando, Hidenori Matsuo, Tadashi Nakamura, Takayuki Sumida, Atsushi Kawakami, Shunya Nakane
Autonomic neuropathy has been reported in autoimmune rheumatic diseases (ARD) including Sjögren's syndrome, systemic sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. However, the pathophysiological mechanism underlying autonomic dysfunction remains unknown to researchers. On the other hand, autoimmune autonomic ganglionopathy (AAG) is an acquired immune-mediated disorder, which causes dysautonomia that is mediated by autoantibodies against ganglionic acetylcholine receptors (gAChRs). The purpose of this review was to describe the characteristics of autonomic disturbance through previous case reports and the functional tests used in these studies and address the importance of anti-gAChR antibodies...
February 16, 2020: International Journal of Molecular Sciences