Katerina Karagiorgou, Maria Dandoulaki, Renato Mantegazza, Francesca Andreetta, Raffaello Furlan, Jon Lindstrom, Paraskevi Zisimopoulou, Elisabeth Chroni, Panagiotis Kokotis, Evangelos Anagnostou, Dimitrios Tzanetakos, Marianthi Breza, Zoe Katsarou, Georgios Amoiridis, Vasileios Mastorodemos, Marianna Bregianni, Anastasios Bonakis, Georgios Tsivgoulis, Konstantinos Voumvourakis, Socrates Tzartos, John Tzartos
BACKGROUND AND OBJECTIVES: Autoantibodies against α3-subunit-containing nicotinic acetylcholine receptors (α3-nAChRs), usually measured by radioimmunoprecipitation assay (RIPA), are detected in patients with autoimmune autonomic ganglionopathy (AAG). However, low α3-nAChR antibody levels are frequently detected in other neurologic diseases with questionable significance. Our objective was to develop a method for the selective detection of the potentially pathogenic α3-nAChR antibodies, seemingly present only in patients with AAG...
May 2022: Neurology® Neuroimmunology & Neuroinflammation