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therapeutic intervention scoring system

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https://www.readbyqxmd.com/read/29901756/introduction-of-a-novel-magnetic-resonance-imaging-based-scoring-system-for-assessing-disease-activity-in-children-with-juvenile-dermatomyositis
#1
Mandela Thyoka, Oba Adekunle, Clarissa Pilkington, Stephen Walters, Owen J Arthurs, Paul Humphries, Karl Johnson, Jeannette Kraft, Caren Landes, Thara Persaud, Raj Sinha, Amaka C Offiah
Objectives: We aimed to develop and assess the reliability of a novel MRI-based scoring system for reporting the severity of MRI findings in children with suspected JDM. Methods: Nine consultant paediatric radiologists independently assessed and scored 40 axial and 30 coronal thigh MR images of children with suspected JDM on two occasions using the juvenile dermatomyositis magnetic resonance Imaging Score (JIS). JIS was calculated for both reads for each plane and each limb, with possible scores ranging from 0 (normal) to 100 (severe)...
June 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29867226/brca1-2-testing-therapeutic-implications-for-breast-cancer-management
#2
REVIEW
Nadine M Tung, Judy E Garber
Testing for germline BRCA1/2 mutations has an established predictive role in breast cancer risk assessment. More recently, studies have also identified BRCA1/2 status as clinically relevant in the selection of therapy for patients already diagnosed with breast cancer. Emerging breast and ovarian cancer research indicate that BRCA status predicts responsiveness to platinum-based chemotherapy, as well as to inhibitors of poly(ADP-ribose) polymerase (PARP), owing to the ability of these interventions to inhibit DNA repair pathways...
June 5, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29861295/stroke-prevention-1-year-clinical-outcomes-and-healthcare-resource-utilization-in-patients-with-atrial-fibrillation-in-france-data-from-the-garfield-af-registry
#3
Jean-Yves Le Heuzey, Jean-Pierre Bassand, Jean-Baptiste Berneau, Paolo Cozzolino, Lucia D'Angiolella, Bernard Doucet, Lorenzo G Mantovani, Michel Martelet, Joseph Mouallem, Jean-Joseph Muller, Karen Pieper
BACKGROUND: GARFIELD-AF is a non-interventional worldwide study of adults with atrial fibrillation. AIMS: To analyse the characteristics of the 1399 patients recruited in France from August 2010 to July 2015, their 1-year outcomes and healthcare resource utilization. METHOD: Patients aged ≥18 years with newly diagnosed atrial fibrillation (≤6 weeks' duration) and ≥1 stroke risk factor were eligible. Patient demographics, medical history and antithrombotic treatment were recorded at baseline...
May 31, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29806412/-applications-of-one-stage-total-spondylectomy-by-anterior-and-posterior-approaches-for-solitary-plasmacytoma-of-cervical-spine
#4
Minhao Wu, Lin Cai, Feifei Yan, Keke Xu, Wenchao Sun, Zhouming Deng, Yuanlong Xie
Objective: To investigate the feasibility of one-stage total spondylectomy by anterior and posterior approaches for treating solitary plasmacytoma (SP) of cervical spine. Methods: Between June 2000 and March 2015, the clinical data, diagnosis, and treatment of 12 patients with SP of cervical spine were retrospectively analyzed. There were 8 males and 4 females, with a mean age of 46 years (range, 28-74 years). The mean disease duration was 8.4 months (range, 3-15 months)...
February 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29794269/wireless-peripheral-nerve-stimulation-for-complex-regional-pain-syndrome-type-i-of-the-upper-extremity-a-case-illustration-introducing-a-novel-technology
#5
Daniel Herschkowitz, Jana Kubias
BACKGROUND: Complex regional pain syndrome (CRPS) is a debilitating painful disorder, cryptic in its pathophysiology and refractory condition with limited therapeutic options. Type I CRPS with its variable relationship to trauma has often no discernible fractures or nerve injuries and remains enigmatic in its response to conservative treatment as well as the other limited interventional therapies. Neuromodulation in the form of spinal cord and dorsal root ganglion stimulation (SCS, DRGS) has shown encouraging results, especially of causalgia or CRPS I of lower extremities...
April 13, 2018: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29755994/therapeutic-effects-of-low-dose-bismuth-subcitrate-on-symptoms-and-health-related-quality-of-life-in-adult-patients-with-irritable-bowel-syndrome-a-clinical-trial
#6
Hamed Daghaghzadeh, Ardalan Memar, Yasaman Mohamadi, Nooshin Rezakhani, Parastoo Safazadeh, Sarina Aghaha, Payman Adibi
Objective: Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract that causes abdominal pain or discomfort and alters bowel with no organic abnormalities. Treatment options for IBS have increased in number in the past decade, and clinicians should not be limited to use only conventional treatments to cure it. This article is a placebo-controlled clinical trial to assess the therapeutic effects of low-dose bismuth subcitrate on symptoms and the health-related quality of life in adult patients with IBS...
January 2018: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29747919/temporal-trends-in-coronary-angiography-and-percutaneous-coronary-intervention-insights-from-the-va-clinical-assessment-reporting-and-tracking-program
#7
Stephen W Waldo, Madhura Gokhale, Colin I O'Donnell, Mary E Plomondon, Javier A Valle, Ehrin J Armstrong, Richard Schofield, Stephan D Fihn, Thomas M Maddox
OBJECTIVES: The aim of this study was to evaluate temporal trends in characteristics and outcomes among patients referred for invasive coronary procedures within a national health care system for veterans. BACKGROUND: Coronary angiography and percutaneous coronary intervention remain instrumental diagnostic and therapeutic interventions for coronary artery disease. METHODS: All coronary angiographic studies and interventions performed in U...
May 14, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29744966/the-effects-of-self-book%C3%A2-art-therapy-on-cancer-related-distress-in-female-cancer-patients-during-active-treatment-a-randomized-controlled-trial
#8
Donna Radl, Maureen Vita, Nancy Gerber, Edward J Gracely, Joke Bradt
OBJECTIVE: National attention on patients' cancer-related emotional distress produced a need for evidence-based, psychosocial interventions in oncology care. The purpose of this study was to evaluate the efficacy of Self-Book© art therapy for emotional distress and psychological well-being of female oncology patients during active oncology treatment. METHODS: Sixty consenting women with cancer were randomly assigned to either a six-session Self-Book© art therapy program or standard care...
May 10, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29725646/prediction-model-and-risk-stratification-tool-for-survival-in-patients-with-ckd
#9
Alexander S Goldfarb-Rumyantzev, Shiva Gautam, Ning Dong, Robert S Brown
Introduction: Because chronic kidney disease (CKD) adversely affects survival, prediction of mortality risk should help to identify individuals requiring therapeutic intervention. The goal of this project was to construct and to validate a risk scoring system and prediction model of the probability of 2-year mortality in a CKD population. Methods: We applied the Woodpecker approach to develop prediction equations using linear, exponential, and combined models. A risk indicator R on a scale of 0 to 10 was calculated as follows: starting with 0, add 0...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29715596/complex-network-theory-for-the-identification-and-assessment-of-candidate-protein-targets
#10
Ken McGarry, Sharon McDonald
In this work we use complex network theory to provide a statistical model of the connectivity patterns of human proteins and their interaction partners. Our intention is to identify important proteins that may be predisposed to be potential candidates as drug targets for therapeutic interventions. Target proteins usually have more interaction partners than non-target proteins, but there are no hard-and-fast rules for defining the actual number of interactions. We devise a statistical measure for identifying hub proteins, we score our target proteins with gene ontology annotations...
April 26, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29705454/effects-of-a-hippotherapy-intervention-on-muscle-spasticity-in-children-with-cerebral-palsy-a-randomized-controlled-trial
#11
David Lucena-Antón, Ignacio Rosety-Rodríguez, Jose A Moral-Munoz
OBJECTIVE: The aim of the present study is to evaluate the effect of a 12 weeks hippotherapy intervention protocol on hip adductors spasticity in children with spastic cerebral palsy. DESIGN: Randomized controlled trial. SETTINGS/LOCATION: The intervention was conducted in an Equestrian and Therapeutic Association. Patients were recruited from a Rehabilitation Unit of Cerebral Palsy. SUBJECTS: A total of 44 children with spastic cerebral palsy (Gross Motor Function Classification System [GMFCS] levels IV-V; 28 boys and 16 girls; aged 8 years 10 months, SD 3 months) were assigned to a treatment (n = 22; mean age 9 years 6 months, SD 3 months) or a control group (n = 22; mean age 8 years 3 months, SD 3 months)...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29671035/-prognostic-relevance-of-tissue-oxygen-saturation-in-patients-in-the-early-stage-of-multiple-organ-dysfunction-syndrome
#12
D Huster, F Härtel, S Nuding, J Schroeder, Y Zhang, K Werdan, H Ebelt
BACKGROUND: Patients in circulatory shock exhibit insufficient peripheral perfusion to ensure adequate oxygenation of vital organs such as the heart and brain. Early detection of reduced tissue oxygen saturation (St O2 ) could be used for rapid therapeutic intervention and thus improve the prognosis of patients in the early stage of multiple organ dysfunction syndrome (MODS). MATERIALS AND METHODS: A total of 60 patients in the early stage of MODS (APACHE [Acute Physiology and Chronic Health Evaluation] II score ≥20) were investigated in a monocentric, prospective, randomized phase II study...
April 18, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29670988/reducing-complications-and-overall-healthcare-costs-of-hip-fracture-management-a-retrospective-study-on-the-application-of-a-diagnostic-therapeutic-pathway-in-the-cosenza-general-hospital
#13
M Loizzo, F Gallo, D Caruso
BACKGROUND: Diagnostic Therapeutic Pathways (DTPs) are multidisciplinary plans designed by each healthcare organization for a specific category of patients to reduce the variability of professional behaviors and to ensure greater safety and better overall healthcare outcomes. Hip fractures are a frequent traumatic injury, particularly in the elderly, and DTPs recommend early surgical intervention, often not done due to organizational challenges and bureaucracy. Medical conditions suggesting a delay are not frequent, however long waiting times not only increase the risk of complications and mortality, but also increase the number of diagnostic test and physician consultations...
May 2018: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29668841/the-impact-of-social-isolation-on-pain-interference-a-longitudinal-study
#14
Nicholas V Karayannis, Isabel Baumann, John A Sturgeon, Markus Melloh, Sean C Mackey
Background: Evidence suggests social interactions play an important role in pain perception. Purpose: The aim of this study was to determine whether social isolation (SI) in people with persistent pain determines pain interference (PI) and physical function over time. Methods: Patients seeking care at a tertiary pain management referral center were administered the Patient Reported Outcome Measurement Information System (PROMIS®) SI, PI, physical function, depression, and average pain intensity item banks at their initial consultation and subsequent visits as part of their routine clinical care...
April 12, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29667952/useful-pharmacodynamic-endpoints-in-children-selection-measurement-and-next-steps
#15
REVIEW
Lauren E Kelly, Yashwant Sinha, Charlotte I S Barker, Joseph F Standing, Martin Offringa
Pharmacodynamic (PD) endpoints are essential for establishing the benefit-to-risk ratio for therapeutic interventions in children and neonates. This article discusses the selection of an appropriate measure of response, the PD endpoint, which is a critical methodological step in designing pediatric efficacy and safety studies. We provide an overview of existing guidance on the choice of PD endpoints in pediatric clinical research. We identified several considerations relevant to the selection and measurement of PD endpoints in pediatric clinical trials, including the use of biomarkers, modeling, compliance, scoring systems, and validated measurement tools...
April 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29660755/-beckwith-wiedemann-syndrome-bws-current-status-of-diagnosis-and-clinical-management-summary-of-the-first-international-consensus-statement
#16
Miriam Elbracht, Dirk Prawitt, Rebekka Nemetschek, Christian Kratz, Thomas Eggermann
Beckwith-Wiedemann syndrome (BWS) belongs to the group of imprinting disorders and is characterized by variable clinical features, including overgrowth, macroglossia, abdominal wall defect, neonatal hypoglycemia, body asymmetry and an increased risk for embryonal tumors. In the majority of cases, molecular alterations of the Imprinting Center (IC) regions in the chromosomal region 11p15.5 can be detected, and a correlation of single clinical features with specific genomic and epigenetic changes is obvious. Therefore, the detailed molecular diagnosis is a prerequisite for a precise prediction of the tumor risk and the tumor spectrum...
April 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29655596/validation-of-the-nursing-workload-scoring-systems-nursing-activities-score-nas-and-therapeutic-intervention-scoring-system-for-critically-ill-children-tiss-c-in-a-greek-paediatric-intensive-care-unit
#17
Alexandra-Stavroula Nieri, Kalliopi Manousaki, Maria Kalafati, Katia Grilio Padilha, Siv K Stafseth, Theodoros Katsoulas, Vasiliki Matziou, Margarita Giannakopoulou
OBJECTIVES: To assess the reliability and validity of the Greek version of Nursing Activities Score (NAS), and Therapeutic Intervention Scoring System for Critically Ill Children (TISS-C) in a Greek Paediatric Intensive Care Unit (PICU). RESEARCH METHODOLOGY: A methodological study was performed in one PICU of the largest Paediatric Hospital in Athens-Greece. The culturally adapted and validated Greek NAS version, enriched according to the Norwegian paediatric one (P-NAS), was used...
April 11, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29622474/the-burden-of-not-weighted-factors-nursing-workload-in-a-medical-intensive-care-unit
#18
Enrico Giuliani, Giovanni Lionte, Paola Ferri, Alberto Barbieri
OBJECTIVES: Body weight and infection status affect nursing workload and are not accounted for in the Therapeutic Intervention Scoring System 28 (TISS-28) and Nine Equivalents of Nursing Manpower Use Score (NEMS). The objective of this study was to analyse the correlation between weight and infection status with TISS 28 and NEMS in a cohort of medical Intensive Care Unit patients. RESEARCH METHODOLOGY: A retrospective observational trial was conducted on the nursing records of 26 randomly selected patients over a 12-month period...
April 2, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29614706/yoga-and-meditation-based-lifestyle-intervention-increases-neuroplasticity-and-reduces-severity-of-major-depressive-disorder-a-randomized-controlled-trial
#19
Madhuri R Tolahunase, Rajesh Sagar, Muneeb Faiq, Rima Dada
BACKGROUND: Current interventions for major depressive disorder (MDD) are suboptimal, and only one third respond to them on initial treatment. Neuroplasticity theories are the basis for several emerging treatments. Evidence on the impact of yoga, a well-known mind-body intervention, on neuroplasticity in MDD is limited. OBJECTIVES: To determine the effects of 12-week yoga- and meditation-based lifestyle intervention (YMLI) on depression severity and systemic biomarkers of neuroplasticity in adult MDD patients on routine drug treatment...
2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29613924/assessing-the-risk-benefit-ratio-of-scoliosis-surgery-in-cerebral-palsy-surgery-is-worth-it
#20
Firoz Miyanji, Luigi A Nasto, Paul D Sponseller, Suken A Shah, Amer F Samdani, Baron Lonner, Burt Yaszay, David H Clements, Unni Narayanan, Peter O Newton
BACKGROUND: The true benefits of scoliosis surgery in cerebral palsy (CP) remain uncertain. Our aims were to determine the benefits of spinal fusion according to health-related quality of life (HRQoL) improvement at long-term follow-up and to explore the effect of surgery-related complications on clinical outcomes. METHODS: The cases of consecutive patients who had Gross Motor Function Classification System (GMFCS) level-IV or V cerebral palsy with 5-year follow-up from a prospective, longitudinal, multicenter database were analyzed...
April 4, 2018: Journal of Bone and Joint Surgery. American Volume
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