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therapeutic intervention scoring system

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https://www.readbyqxmd.com/read/28062203/semi-mechanistic-computer-simulation-of-psychotic-symptoms-in-schizophrenia-with-a-model-of-a-humanized-cortico-striatal-thalamocortical-loop
#1
Athan Spiros, Patrick Roberts, Hugo Geerts
Despite new insights into the pathophysiology of schizophrenia and clinical trials with highly selective drugs, no new therapeutic breakthroughs have been identified. We present a semi-mechanistic Quantitative Systems Pharmacology (QSP) computer model of a biophysically realistic cortical-striatal-thalamo-cortical loop. The model incorporates the direct, indirect and hyperdirect pathway of the basal ganglia and CNS drug targets that modulate neuronal firing, based on preclinical data about their localization and coupling to voltage-gated ion channels...
January 3, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28033582/diosgenin-ameliorates-development-of-neuropathic-pain-in-diabetic-rats-involvement-of-oxidative-stress-and-inflammation
#2
Zahra Kiasalari, Tayebeh Rahmani, Narges Mahmoudi, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Neuropathic pain is one of the prevalent complications of diabetes mellitus (DM). Oxidative stress and inflammation are the principal determinants for its development. Pharmacological interventions targeted at alleviating or suppressing these pathways are clinically promising. Diosgenin is a natural steroidal saponin with anti-diabetic and multiple protective properties. This study was designed to study the efficacy of chronic diosgenin administration on alleviation of hyperalgesia in streptozotocin (STZ)-diabetic rats...
December 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27977849/conservative-interventions-for-treating-middle-third-clavicle-fractures-in-adolescents-and-adults
#3
REVIEW
Mário Lenza, Flávio Faloppa
BACKGROUND: Clavicle (collarbone) fractures account for around 4% of all fractures. Most (76%) clavicle fractures involve the middle-third section of the clavicle. Treatment of these fractures is usually non-surgical (conservative). Commonly used treatments are arm slings, strapping and figure-of-eight bandages.This is an update of a Cochrane review first published in 2009 and updated in 2014. OBJECTIVES: To evaluate the effects (benefits and harms) of different methods for conservative (non-operative) treatment for acute (treated soon after injury) middle third clavicle fractures in adolescents and adults...
15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27967297/active-surveillance-as-a-therapeutic-option-for-patients-with-low-risk-prostate-cancer-according-to-the-2014-international-society-of-urological-pathology-grading-system-a-review
#4
Burkhard Helpap, Heidrun Gevensleben
Extended prostate-specific antigen screening and the tightly focused execution of biopsies have resulted in an increased rate of detection, and thereby increased interventional treatment, of prostate cancer (PCa). The potential overdiagnosis and overtreatment of PCa patients have repeatedly been criticized in national and international literature. Controlled monitoring of patients in the setting of active surveillance (AS) can prevent overtreatment and the needless impairment of quality of life. The prerequisite for this treatment strategy is the diagnosis of low-grade/risk PCa...
December 14, 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27873233/four-score-predicts-early-outcome-in-patients-after-traumatic-brain-injury
#5
Tee-Tau Eric Nyam, Kam-Hou Ao, Shu-Yu Hung, Mei-Li Shen, Tzu-Chieh Yu, Jinn-Rung Kuo
BACKGROUND: The aim of the study was to determine whether the Full Outline of UnResponsiveness (FOUR) score, which includes eyes opening (E), motor function (M), brainstem reflex (B), and respiratory pattern (R), can be used as an alternate method to the Glasgow Coma Scale (GCS) in predicting intensive care unit (ICU) mortality in traumatic brain injury (TBI) patients. METHODS: From January 2015 to June 2015, patients with isolated TBI admitted to the ICU were enrolled...
November 21, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27859866/modelling-idiopathic-parkinson-disease-as-a-complex-illness-can-inform-incidence-rate-in-healthy-adults-the%C3%A2-pr-edigt-score
#6
Michael G Schlossmacher, Julianna J Tomlinson, Goncalo Santos, Bojan Shutinoski, Earl G Brown, Douglas Manuel, Tiago Mestre
Fifty-five years after the concept of dopamine replacement therapy was introduced, Parkinson disease (PD) remains an incurable neurological disorder. To date, no disease-modifying therapeutic has been approved. The inability to predict PD incidence risk in healthy adults is seen as a limitation in drug development, because by the time of clinical diagnosis ≥ 60% of dopamine neurons have been lost. We have designed an incidence prediction model founded on the concept that the pathogenesis of PD is similar to that of many disorders observed in ageing humans, i...
January 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27856124/enhanced-molecular-aging-in-late-life-depression-the-senescent-associated-secretory-phenotype
#7
Breno Satler Diniz, Charles F Reynolds, Etienne Sibille, Chien-Wei Lin, George Tseng, Francis Lotrich, Howard J Aizenstein, Meryl A Butters
OBJECTIVE: This study aims to investigate whether a systemic molecular pattern associated with aging (senescent-associated secretory phenotype [SASP]) is elevated in adults with late-life depression (LLD), compared with never-depressed elderly comparison participants. DESIGN: Cross-sectional study. PARTICIPANTS: We included 111 older adults (80 with LLD and 31 comparison participants) in this study. MEASUREMENT: A panel of 22 SASP-related proteins was extracted from a previous multiplex protein panel performed in these participants...
January 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27776269/coping-strategies-as-a-mediator-of-internet-delivered-psychosocial-treatment-secondary-analysis-from-a-nida-ctn-multisite-effectiveness-trial
#8
Annie Lévesque, Aimee N C Campbell, Martina Pavlicova, Mei-Chen Hu, Robrina Walker, Erin A McClure, Udi E Ghitza, Genie Bailey, Maxine Stitzer, Edward V Nunes
OBJECTIVE: Coping strategies are a predictor of abstinence among patients with substance use disorders. However, little is known regarding the role of coping strategies in the effectiveness of the Community Reinforcement Approach (CRA). Using data from a 12week randomized control trial assessing the effectiveness of the Therapeutic Education System (TES), an internet-delivered version of the CRA combined with contingency management, we tested the role of coping strategies as a mediator of treatment effectiveness...
February 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/27769953/evaluating-the-effect-of-web-based-iranian-diabetic-personal-health-record-app-on-self-care-status-and-clinical-indicators-randomized-controlled-trial
#9
Amirabbas Azizi, Robab Aboutorabi, Zahra Mazloum-Khorasani, Monavar Afzal-Aghaea, Hamed Tabesh, Mahmood Tara
BACKGROUND: There are 4 main types of chronic or noncommunicable diseases. Of these, diabetes is one of the major therapeutic concerns globally. Moreover, Iran is among the countries with the highest incidence of diabetic patients. Furthermore, library-based studies by researchers have shown that thus far no study has been carried out to evaluate the relationship between Web-based diabetic personal health records (DPHR) and self-care indicators in Iran. OBJECTIVE: The objective of this study is to examine the effect of Web-based DPHR on self-care status of diabetic patients in an intervention group as compared with a control group...
October 21, 2016: JMIR Medical Informatics
https://www.readbyqxmd.com/read/27767944/feasibility-of-using-an-arm-weight-supported-training-system-to-improve-hand-function-skills-in-children-with-hemiplegia
#10
Swetha Krishnaswamy, Daniel J Coletti, Hilary Berlin, Kathleen Friel
OBJECTIVE: This investigation was a pilot feasibility trial evaluating the use of an arm-weight-supported training device to improve upper-extremity function in children with hemiplegia. METHOD: A single-group within-subject design was used. Participants were 6 children ages 7-17 yr with upper-extremity weakness secondary to hemiplegia. The intervention consisted of 15-18 treatment sessions using an arm-weight-supported training device with the affected upper extremity...
November 2016: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/27756379/a-longitudinal-study-of-empathy-in-pre-clinical-and-clinical-medical-students-and-clinical-supervisors
#11
Sarah Mahoney, Ruth M Sladek, Tim Neild
BACKGROUND: Although appropriate empathy in health professionals is essential, a loss of empathy can occur during medical education. The structure of clinical learning may be one factor that is implicated in a loss of empathy. This study examines student and doctor empathy, and possible associations between empathy and the structure of clinical learning. METHODS: There were three groups of participants: medical students (n = 281), who completed a longitudinal survey consisting of the Jefferson Scale of Empathy and an open question about empathy at the beginning and end of the 2013 academic year; private doctors (medical practitioners) in South Australia (n = 78) who completed a survey consisting of the Jefferson Scale of Empathy and an open question about empathy at the end of the students' academic year; and doctors (medical practitioners) from public teaching hospitals (n = 72) in southern Adelaide, South Australia who completed a survey consisting of the Jefferson Scale of Empathy at the end of the students' academic year ...
October 18, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27742400/thyroid-storm-in-a-patient-with-trauma-a-challenging-diagnosis-for-the-emergency-physician-case-report-and-literature-review
#12
Hsiang-I Wang, Giou-Teng Yiang, Chin-Wang Hsu, Jen-Chun Wang, Chien-Hsing Lee, Yu-Long Chen
BACKGROUND: Thyroid storm, an endocrine emergency, remains a diagnostic and therapeutic challenge. It is recognized to develop as a result of several factors, including infection, surgery, acute illness, and rarely, trauma. Recognition of thyroid storm in a trauma patient is difficult because the emergency physician usually focuses on managing more obvious injuries. OBJECTIVE OF THE REVIEW: We present a case of trauma-related thyroid storm and review the previous literature on posttraumatic thyroid storm to delineate risk factors of the disease...
October 11, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27730775/towards-developing-a-scoring-system-for-febrile-thrombocytopenia
#13
Prasita Kshirsagar, Shaylika Chauhan, Dinesh Samel
BACKGROUND: The authors wished to develop a scoring system for evaluating patients presenting with febrile thrombocytopenia for risk stratification, predicting patient outcome and optimization of care especially in resource poor countries. OBJECTIVE: 1. To decide a protocol in the management of patients with fever and thrombocytopenia. 2. To develop screening or therapeutic guidelines (early warning score-EWS) in febrile thrombocytopenic patients and decide about therapeutic interventions...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27681697/the-fibrolytic-potentials-of-vitamin-d-and-thymoquinone-remedial-therapies-insights-from-liver-fibrosis-established-by-ccl4-in-rats
#14
Abdelghany Hassan Abdelghany, Mohammad A BaSalamah, Shakir Idris, Jawwad Ahmad, Bassem Refaat
BACKGROUND: Vitamin D (VitD) and thymoquinone (TQ) are nutraceutical agents with well-known immunomodulatory and hepatoprotective properties. This study measured whether VitD and TQ, individually or combined, could have direct fibrolytic activities and/or enhanced performance during remedial treatment of liver fibrosis established by CCl4 in rats. METHODS: Eighty five male Wistar rats were used as 10 negative controls (NC) and the remainders were distributed equally into 5 groups: short (S-PC) and long (L-PC) positive controls, TQ, VitD and VitD/TQ groups...
September 29, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27680056/nursing-workload-and-occurrence-of-adverse-events-in-intensive-care-a-systematic-review
#15
Andrea Carvalho de Oliveira, Paulo Carlos Garcia, Lilia de Souza Nogueira
OBJECTIVE: To identifyevidences of the influence of nursing workload on the occurrence of adverse events (AE) in adult patients admitted to the intensive care unit (ICU). METHOD: A systematic literature review was conducted in the databases MEDLINE, CINAHL, LILACS, SciELO, BDENF, and Cochrane from studies in English, Portuguese, or Spanish, published by 2015. The analyzed AE were infection, pressure ulcer (PU), patient falls, and medication errors. RESULTS: Of 594 potential studies, eight comprised the final sample of the review...
July 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27664837/insights-into-the-epigenetic-mechanisms-involving-histone-lysine-methylation-and-demethylation-in-ischemia-induced-damage-and-repair-has-therapeutic-implication
#16
Sumana Chakravarty, Priya Jhelum, Unis Ahmad Bhat, Wenson D Rajan, Swati Maitra, Salil S Pathak, Anant B Patel, Arvind Kumar
Cerebral ischemic stroke is one of the leading causes of death and disability worldwide. Therapeutic interventions to minimize ischemia-induced neural damage are limited due to poor understanding of molecular mechanisms mediating complex pathophysiology in stroke. Recently, epigenetic mechanisms mostly histone lysine (K) acetylation and deacetylation have been implicated in ischemic brain damage and have expanded the dimensions of potential therapeutic intervention to the systemic/local administration of histone deacetylase inhibitors...
January 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27658523/increased-need-for-interventions-predicts-mortality-in-the-critically-ill
#17
I Efendijev, R Raj, M B Skrifvars, S Hoppu, M Reinikainen
INTRODUCTION: The aim of this study was to determine the association of early treatment intensity with hospital mortality of intensive care unit (ICU) patients. METHODS: We performed an observational study based on a national ICU registry. We included adult patients treated in Finnish ICUs between 2003 and 2013 with the length of ICU stay of more than 3 days. We measured treatment intensity with the Therapeutic Intervention Scoring System (TISS-76). We assessed mean and daily TISS scores...
November 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27651219/challenges-faced-by-cross-sectional-imaging-and-histological-endpoints-in-clinical-trials
#18
Vincenzo Villanacci, Filip Baert, Freddy Cornillie, Gert De Hertogh, Julián Panés
In patients with inflammatory bowel disease, a dissociation can occur between symptoms and presence of inflammatory lesions. This dissociation has led to the recognition that objective measures of disease activity together with clinical assessment should be co-primary endpoints in clinical trials. Objective assessment of inflammatory lesions has classically relied on ileocolonoscopy. However, examination with endoscopy cannot always be complete and does not evaluate transmural changes. Furthermore, histological alterations may persist in the presence of mild or even absent endoscopy lesions...
September 20, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27650337/anesthesia-management-during-aortic-surgery-preoperative-patient-assessment
#19
REVIEW
Adrian Mahlmann, Norbert Weiss
Patients with aortic diseases have a high rate of cardiac, cerebrovascular, or pulmonary comorbidities. Open surgery or endovascular interventions of the aorta are associated with high perioperative cardiac risk. Simple scoring systems for preoperative risk stratification can be used to identify high-risk patients. In these patients, further diagnostic and therapeutic interventions are required to reduce perioperative morbidity and mortality. In contrast, low-risk patients can be identified, who may proceed to intervention without additional cardiopulmonary diagnostic testing...
September 2016: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/27631152/repetitive-transcranial-magnetic-stimulation-rtms-combined-with-cognitive-training-is-a-safe-and-effective-modality-for-the-treatment-of-alzheimer-s-disease-clinical-experience
#20
Jose Martin Rabey, Evgenia Dobronevsky
Alzheimer's disease (AD) is the most common type of dementia among the elderly. Common treatments available and non-pharmacological interventions have their limitations, and new therapeutic approaches are critically needed. Transcranial magnetic stimulation (TMS) is a non-invasive technique that generates an electric current-inducing modulation in cortical excitability. The previous clinical trials showed that combinations of rTMS and cognitive training (rTMS-COG), as provided by the NeuroAD medical device system, offer a novel, safe, and effective method improving mild-to-moderate AD patients...
December 2016: Journal of Neural Transmission
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