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therapeutic intervention scoring system

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https://www.readbyqxmd.com/read/29214694/myelodysplastic-syndromes-2018-update-on-diagnosis-risk-stratification-and-management
#1
Guillermo Montalban-Bravo, Guillermo Garcia-Manero
DISEASE OVERVIEW: The myelodysplastic syndromes (MDS) are a very heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). MDS occurs more frequently in older males and in individuals with prior exposure to cytotoxic therapy. DIAGNOSIS: Diagnosis of MDS is based on morphological evidence of dysplasia upon visual examination of a bone marrow aspirate and biopsy. Information obtained from additional studies such as karyotype, flow cytometry or molecular genetics is usually complementary and may help refine diagnosis...
January 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29201115/effect-of-vitamin-d-supplementation-on-procalcitonin-as-prognostic-biomarker-in-patients-with-ventilator-associated-pneumonia-complicated-with-vitamin-d-deficiency
#2
Amir Ebrahim Miroliaee, Jamshid Salamzadeh, Shervin Shokouhi, Alireza Fatemi, Seyed Hossein Ardehali, Mohammad Reza Hajiesmaeili, Zahra Sahraei
Ventilator-associated pneumonia (VAP) is a common and serious problem that develops after more than 48 h of mechanical ventilation. Improving the activity of immune system with vitamin D, and its consequent impact on prognostic biomarkers of VAP was studied in the current study. A randomized double blind placebo controlled clinical trial was designed. A total of 46 patients with VAP, who were suffering from vitamin D deficiency, were randomly allocated into the study groups of placebo (n=22) and treatment (n=24) The treatment group received 300,000 units of intramuscular vitamin D...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29197180/acupuncture-for-neuropathic-pain-in-adults
#3
REVIEW
Zi Yong Ju, Ke Wang, Hua Shun Cui, Yibo Yao, Shi Min Liu, Jia Zhou, Tong Yu Chen, Jun Xia
BACKGROUND: Neuropathic pain may be caused by nerve damage, and is often followed by changes to the central nervous system. Uncertainty remains regarding the effectiveness and safety of acupuncture treatments for neuropathic pain, despite a number of clinical trials being undertaken. OBJECTIVES: To assess the analgesic efficacy and adverse events of acupuncture treatments for chronic neuropathic pain in adults. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, four Chinese databases, ClinicalTrials...
December 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29185965/ultrasound-changes-in-synovial-abnormalities-induced-by-treatment-in-juvenile-idiopathic-arthritis
#4
Stefano Lanni, E H Pieter van Dijkhuizen, Federica Vanoni, Stefania Viola, Francesca Magnaguagno, Gian Michele Magnano, Carlo Gandolfo, Angelo Ravelli, Clara Malattia
OBJECTIVES: To investigate the capacity of ultrasound (US) to detect improvement of synovial abnormalities induced by treatment in juvenile idiopathic arthritis (JIA). METHODS: Eighty-three joints (33 knees, 22 tibiotalar, 10 wrists, 9 elbows, 9 subtalar joints) of 33 patients with new-onset JIA were assessed by US at study entry and 6 months after a therapeutic intervention. Each joint was scored for grey-scale (GS) and power Doppler (PD) abnormalities according to a 4-point semiquantitative scale...
November 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29174793/footwear-interventions-for-foot-pain-function-impairment-and-disability-for-people-with-foot-and-ankle-arthritis-a-literature-review
#5
REVIEW
Mike Frecklington, Nicola Dalbeth, Peter McNair, Peter Gow, Anita Williams, Matthew Carroll, Keith Rome
OBJECTIVE: To conduct a literature review on the effectiveness of footwear on foot pain, function, impairment and disability for people with foot and ankle arthritis. METHODS: A search of the electronic databases Scopus, Medline, CINAHL, SportDiscus and the Cochrane Library was undertaken in September 2017. The key inclusion criteria were studies reporting on findings of footwear interventions for people with arthritis with foot pain, function, impairment and/or disability...
November 3, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29158960/a-combined-treatment-approach-emphasizing-impairment-based-manual-therapy-and-exercise-for-hip-related-compensatory-injury-in-elite-athletes-a-case-series
#6
Steve Short, Gretchen Short, Donald Strack, Philip Anloague, Brian Brewster
Background/Purpose: Athletes experiencing hip, groin, and low back pain often exhibit similar clinical characteristics. Individuals with hip, groin and low back pain may have the presence of multiple concurrent pathoanatomical diagnoses. Regardless, similar regional characteristics and dysfunction may contribute to the patient's chief complaint, potentially creating a sub-group of individuals that may be defined by lumbopelvic and hip mobility limitations, motor control impairments, and other shared clinical findings...
November 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29158024/evaluation-of-the-simplified-therapeutic-intervention-scoring-system-chinese-version
#7
Zi-Wen Wang, Jing Zheng, Li-Ming You, Yue-Xiu Wang, Ming-Rong Gao, Xiang-Dong Guan
OBJECTIVE: To prepare the Simplified Therapeutic Intervention Scoring System (TISS-28) to measure nursing workload in Intensive Care Units in Guangdong Province of China. METHODS: A non-experimental descriptive study was conducted in the intensive care units in the Province. TISS-28, TISS-76, Acute Physiology and Chronic Health Evaluation (APACHE II) were all measured. RESULTS: There were significant positive correlations between TISS-28 and APACHE II (n=91, r=0...
November 17, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29155867/spectrum-of-pathogen-and-model-specific-histopathologies-in-mouse-models-of-acute-pneumonia
#8
Kristina Dietert, Birgitt Gutbier, Sandra M Wienhold, Katrin Reppe, Xiaohui Jiang, Ling Yao, Catherine Chaput, Jan Naujoks, Markus Brack, Alexandra Kupke, Christin Peteranderl, Stephan Becker, Carolin von Lachner, Nelli Baal, Hortense Slevogt, Andreas C Hocke, Martin Witzenrath, Bastian Opitz, Susanne Herold, Holger Hackstein, Leif E Sander, Norbert Suttorp, Achim D Gruber
Pneumonia may be caused by a wide range of pathogens and is considered the most common infectious cause of death in humans. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. Despite progress in other fields of tissue imaging, histopathology remains the most conclusive and practical read out tool for the descriptive and semiquantitative evaluation of mouse pneumonia and therapeutic interventions...
2017: PloS One
https://www.readbyqxmd.com/read/29154148/the-relationship-between-executive-functions-and-emotion-regulation-in-females-attending-therapeutic-community-treatment-for-substance-use-disorder
#9
Ely M Marceau, Peter J Kelly, Nadia Solowij
BACKGROUND: Difficulties in emotion regulation influence the development of substance use disorder (SUD), its severity, course, treatment outcomes, and relapse. Impaired executive functions (EFs) are common in SUD populations and may relate to emotion dysregulation. The current study tested whether performance on three basic EF tasks ('working memory', 'inhibition', and 'task-switching') and/or inventory-based assessment of EF were related to difficulties in emotion regulation in females attending residential SUD therapeutic community treatment...
November 12, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29121645/novel-lung-imaging-biomarkers-and-skin-gene-expression-subsetting-in-dasatinib-treatment-of-systemic-sclerosis-associated-interstitial-lung-disease
#10
Viktor Martyanov, Grace-Hyun J Kim, Wendy Hayes, Shuyan Du, Bishu J Ganguly, Oumar Sy, Sun Ku Lee, Galina S Bogatkevich, Gary L Schieven, Elena Schiopu, Roberta Gonçalves Marangoni, Jonathan Goldin, Michael L Whitfield, John Varga
BACKGROUND: There are no effective treatments or validated clinical response markers in systemic sclerosis (SSc). We assessed imaging biomarkers and performed gene expression profiling in a single-arm open-label clinical trial of tyrosine kinase inhibitor dasatinib in patients with SSc-associated interstitial lung disease (SSc-ILD). METHODS: Primary objectives were safety and pharmacokinetics. Secondary outcomes included clinical assessments, quantitative high-resolution computed tomography (HRCT) of the chest, serum biomarker assays and skin biopsy-based gene expression subset assignments...
2017: PloS One
https://www.readbyqxmd.com/read/29121480/palliative-care-planner-pcplanner-a-pilot-study-to-evaluate-acceptability-and-usability-of-an-electronic-health-records-system-integrated-needs-targeted-app-platform
#11
Christopher E Cox, Derek M Jones, Wen Reagan, Mary D Key, Vinca Chow, Jessica McFarlin, David Casarett, Claire J Creutzfeldt, Sharron L Docherty
RATIONALE: The quality and patient-centeredness of intensive care unit (ICU)-based palliative care delivery is highly variable. OBJECTIVE: To develop and pilot an app platform for clinicians, ICU patients, and their family members that enhances the delivery of needs-targeted palliative care. METHODS: In the Development Phase of the study, we developed an electronic health record (EHR) system-integrated mobile web app system prototype, PCplanner (Palliative Care Planner)...
November 9, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29100154/oxytocin-plasma-levels-predict-the-outcome-of-psychotherapy-a-pilot-study-in-chronic-depression
#12
A Jobst, L Sabaß, D Hall, B Brücklmeier, A Buchheim, J Hall, N Sarubin, P Zill, P Falkai, E-L Brakemeier, F Padberg
BACKGROUND: Oxytocin is associated with bonding and social deficits in psychiatric disorders and has also been discussed as a potential therapeutic intervention to augment psychotherapy. The Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a specific form of psychotherapy for chronic depression, an illness in which interpersonal deficits play a major role. In this pilot study, we investigated whether Oxytocin plasma levels predict the clinical outcome of chronic depressive patients after CBASP...
October 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29095245/prospective-multicenter-randomized-crossover-clinical-trial-comparing-the-safety-and-effectiveness-of-cooled-radiofrequency-ablation-with-corticosteroid-injection-in-the-management-of-knee-pain-from-osteoarthritis
#13
Tim Davis, Eric Loudermilk, Michael DePalma, Corey Hunter, David Lindley, Nilesh Patel, Daniel Choi, Marc Soloman, Anita Gupta, Mehul Desai, Asokumar Buvanendran, Leonardo Kapural
BACKGROUND AND OBJECTIVES: Osteoarthritis (OA) of the knee affects the aging population and has an associated influence on the health care system. Rigorous studies evaluating radiofrequency ablation for OA-related knee pain are lacking. This study compared long-term clinical safety and effectiveness of cooled radiofrequency ablation (CRFA) with intra-articular steroid (IAS) injection in managing OA-related knee pain. METHODS: This is a prospective, multicenter, randomized trial with 151 subjects with chronic (≥6 months) knee pain that was unresponsive to conservative modalities...
November 1, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29071048/changes-in-antimicrobial-prescribing-behavior-after-the-introduction-of-the-antimicrobial-stewardship-program-a-pre-and-post-intervention-survey
#14
Ruchir Chavada, Harry N Walker, Deborah Tong, Amy Murray
The introduction of an antimicrobial stewardship (AMS) program is associated with a change in antimicrobial prescribing behavior. A proposed mechanism for this change is by impacting the prescribing etiquette described in qualitative studies. This study sought to detect a change in prescribing attitudes 12 months after the introduction of AMS and gauge utility of various AMS interventions. Surveys were distributed to doctors in two regional Australian hospitals on a convenience basis 6 months before, and 12 months after, the introduction of AMS...
October 2, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/29069871/leptomeningeal-disease-current-diagnostic-and-therapeutic-strategies
#15
REVIEW
Gautam Nayar, Tiffany Ejikeme, Pakawat Chongsathidkiet, Aladine A Elsamadicy, Kimberly L Blackwell, Jeffrey M Clarke, Shivanand P Lad, Peter E Fecci
Leptomeningeal disease has become increasingly prevalent as novel therapeutic interventions extend the survival of cancer patients. Although a majority of leptomeningeal spread occurs secondary to breast cancer, lung cancer, and melanoma, a wide variety of malignancies have been reported as primary sources. Symptoms on presentation are equally diverse, often involving a combination of neurological deficits with the possibility of obstructive hydrocephalus. Diagnosis is definitively made via cerebrospinal fluid cytology for malignant cells, but neuro-imaging with high quality T1-weighted magnetic resonance imaging can aid diagnosis and localization...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29033850/designing-dietary-recommendations-using-system-level-interactomics-analysis-and-network-based-inference
#16
Tingting Zheng, Yueqiong Ni, Jun Li, Billy K C Chow, Gianni Panagiotou
Background: A range of computational methods that rely on the analysis of genome-wide expression datasets have been developed and successfully used for drug repositioning. The success of these methods is based on the hypothesis that introducing a factor (in this case, a drug molecule) that could reverse the disease gene expression signature will lead to a therapeutic effect. However, it has also been shown that globally reversing the disease expression signature is not a prerequisite for drug activity. On the other hand, the basic idea of significant anti-correlation in expression profiles could have great value for establishing diet-disease associations and could provide new insights into the role of dietary interventions in disease...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28967543/high-short-term-failure-rate-associated-with-decellularized-osteochondral-allograft-for-treatment-of-knee-cartilage-lesions
#17
Christine C Johnson, Daniel J Johnson, Grant H Garcia, Dean Wang, Mollyann Pais, Ryan M Degen, Alissa J Burge, Riley J Williams
PURPOSE: To report the short-term clinical and radiographic outcomes following the use of decellularized osteochondral (OC) allograft plugs in the treatment of distal femoral OC lesions. METHODS: An Institutional Review Board-approved database with prospectively collected data was used to identify patients treated with the decellularized OC allograft plugs implant. Demographic information, patient-reported outcomes, magnetic resonance imaging (MRI), and the number and type of reoperations were assessed...
September 26, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28960550/incidence-and-risk-factors-associated-with-the-development-of-pressure-ulcers-in-an-intensive-care-unit
#18
María Isabel González-Méndez, Marta Lima-Serrano, Catalina Martín-Castaño, Inmaculada Alonso-Araujo, Joaquín Salvador Lima-Rodríguez
AIMS AND OBJECTIVES: To determinate the incidence, incidence rate and risk factors of pressure ulcers (PUs) in critical care patients. BACKGROUND: PUs represent one of the most frequent health problems in clinical practice. Specifically, critical patients who are hospitalized in intensive care units (ICU) have a higher risk of developing a PU, with an incidence that fluctuates between 3.3% and 52.9% according to previous studies. DESIGN: Prospective cohort study...
September 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28943457/clinical-staging-of-fibrodysplasia-ossificans-progressiva-fop
#19
Robert J Pignolo, Frederick S Kaplan
Fibrodyplasia ossificans progressiva (FOP) is an ultra-rare genetic condition of heterotopic ossification (HO) that results in progressive loss of joint function, ultimately rendering movement impossible. Death is most commonly the result of thoracic insufficiency syndrome, or complications related to recurrent respiratory infections. There are no current treatments for FOP, but early and emerging clinical trials offer hope for this devastating disease. With the recent reporting of a comprehensive global natural history study, scales to assess joint dysfunction, and a more accurate prediction of joint survival, it is now possible to construct a conceptual framework for the clinical staging of FOP...
September 21, 2017: Bone
https://www.readbyqxmd.com/read/28942909/a-systematic-review-of-exercise-systematic-reviews-in-the-cancer-literature-2005-2017
#20
REVIEW
Nicole L Stout, Jennifer Baima, Anne K Swisher, Kerri M Winters-Stone, Judith Welsh
BACKGROUND: Evidence supports the benefits of exercise for patients with cancer; however, specific guidance for clinical decision making regarding exercise timing, frequency, duration, and intensity is lacking. Efforts are needed to optimize clinical recommendations for exercise in the cancer population. OBJECTIVES: To aggregate information regarding the benefit of exercise through a systematic review of existing systematic reviews in the cancer exercise literature...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
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