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therapeutic intervention scoring system

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https://www.readbyqxmd.com/read/29667952/useful-pharmacodynamic-endpoints-in-children-selection-measurement-and-next-steps
#1
REVIEW
Lauren E Kelly, Yashwant Sinha, Charlotte I S Barker, Joseph F Standing, Martin Offringa
Pharmacodynamic (PD) endpoints are essential for establishing the benefit-to-risk ratio for therapeutic interventions in children and neonates. This article discusses the selection of an appropriate measure of response, the PD endpoint, which is a critical methodological step in designing pediatric efficacy and safety studies. We provide an overview of existing guidance on the choice of PD endpoints in pediatric clinical research. We identified several considerations relevant to the selection and measurement of PD endpoints in pediatric clinical trials, including the use of biomarkers, modeling, compliance, scoring systems, and validated measurement tools...
April 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29660755/-beckwith-wiedemann-syndrome-bws-current-status-of-diagnosis-and-clinical-management-summary-of-the-first-international-consensus-statement
#2
Miriam Elbracht, Dirk Prawitt, Rebekka Nemetschek, Christian Kratz, Thomas Eggermann
Beckwith-Wiedemann syndrome (BWS) belongs to the group of imprinting disorders and is characterized by variable clinical features, including overgrowth, macroglossia, abdominal wall defect, neonatal hypoglycemia, body asymmetry and an increased risk for embryonal tumors. In the majority of cases, molecular alterations of the Imprinting Center (IC) regions in the chromosomal region 11p15.5 can be detected, and a correlation of single clinical features with specific genomic and epigenetic changes is obvious. Therefore, the detailed molecular diagnosis is a prerequisite for a precise prediction of the tumor risk and the tumor spectrum...
April 16, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29655596/validation-of-the-nursing-workload-scoring-systems-nursing-activities-score-nas-and-therapeutic-intervention-scoring-system-for-critically-ill-children-tiss-c-in-a-greek-paediatric-intensive-care-unit
#3
Alexandra-Stavroula Nieri, Kalliopi Manousaki, Maria Kalafati, Katia Grilio Padilha, Siv K Stafseth, Theodoros Katsoulas, Vasiliki Matziou, Margarita Giannakopoulou
OBJECTIVES: To assess the reliability and validity of the Greek version of Nursing Activities Score (NAS), and Therapeutic Intervention Scoring System for Critically Ill Children (TISS-C) in a Greek Paediatric Intensive Care Unit (PICU). RESEARCH METHODOLOGY: A methodological study was performed in one PICU of the largest Paediatric Hospital in Athens-Greece. The culturally adapted and validated Greek NAS version, enriched according to the Norwegian paediatric one (P-NAS), was used...
April 11, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29622474/the-burden-of-not-weighted-factors-nursing-workload-in-a-medical-intensive-care-unit
#4
Enrico Giuliani, Giovanni Lionte, Paola Ferri, Alberto Barbieri
OBJECTIVES: Body weight and infection status affect nursing workload and are not accounted for in the Therapeutic Intervention Scoring System 28 (TISS-28) and Nine Equivalents of Nursing Manpower Use Score (NEMS). The objective of this study was to analyse the correlation between weight and infection status with TISS 28 and NEMS in a cohort of medical Intensive Care Unit patients. RESEARCH METHODOLOGY: A retrospective observational trial was conducted on the nursing records of 26 randomly selected patients over a 12-month period...
April 2, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29614706/yoga-and-meditation-based-lifestyle-intervention-increases-neuroplasticity-and-reduces-severity-of-major-depressive-disorder-a-randomized-controlled-trial
#5
Madhuri R Tolahunase, Rajesh Sagar, Muneeb Faiq, Rima Dada
BACKGROUND: Current interventions for major depressive disorder (MDD) are suboptimal, and only one third respond to them on initial treatment. Neuroplasticity theories are the basis for several emerging treatments. Evidence on the impact of yoga, a well-known mind-body intervention, on neuroplasticity in MDD is limited. OBJECTIVES: To determine the effects of 12-week yoga- and meditation- based lifestyle intervention (YMLI) on depression severity and systemic biomarkers of neuroplasticity in adult MDD patients on routine drug treatment...
March 25, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29613924/assessing-the-risk-benefit-ratio-of-scoliosis-surgery-in-cerebral-palsy-surgery-is-worth-it
#6
Firoz Miyanji, Luigi A Nasto, Paul D Sponseller, Suken A Shah, Amer F Samdani, Baron Lonner, Burt Yaszay, David H Clements, Unni Narayanan, Peter O Newton
BACKGROUND: The true benefits of scoliosis surgery in cerebral palsy (CP) remain uncertain. Our aims were to determine the benefits of spinal fusion according to health-related quality of life (HRQoL) improvement at long-term follow-up and to explore the effect of surgery-related complications on clinical outcomes. METHODS: The cases of consecutive patients who had Gross Motor Function Classification System (GMFCS) level-IV or V cerebral palsy with 5-year follow-up from a prospective, longitudinal, multicenter database were analyzed...
April 4, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29613879/the-relationship-between-nursing-workload-quality-of-care-and-nursing-payment-in-intensive-care-units
#7
Li-Yin Chang, Hsiu-Hui Yu, Yann-Fen C Chao
BACKGROUND: Nursing workload is highly associated with patient safety. It has been argued that the imbalance between nursing payment and nursing workload in Taiwan National Health Insurance (NHI)-covered intensive care units (ICUs) has resulted in the inadequate allocation of nursing manpower. However, limited empirical data are currently available to support this argument. PURPOSE: The aim of this study was to investigate the correlation between nursing workload, quality of care, and NHI-covered nursing payments in ICU settings...
April 3, 2018: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29606258/treatment-of-iga-nephropathy-recent-advances-and-prospects
#8
REVIEW
Rosanna Coppo
IgA nephropathy, identified 50 years ago in France, is the most frequent glomerular disease worldwide. The course is variable, but in most of the cases there is a relentless decline in renal function, reaching end-stage renal failure in 10-60% of the cases after 10 years and in 40% after 20 years. These data justify the interest for finding a suitable therapeutic approach particularly in progressive cases. A supportive care, including renin-angiotensin system inhibitors is the priority in cases with slowly declining renal function, particularly when developing proteinuria...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29603815/the-relationship-of-delirium-and-risk-factors-in-cardiology-intensive-care-unit-patients-with-the-nursing-workload
#9
A Öztürk Birge, T Bedük
AIMS AND OBJECTIVES: The aim of the study is to evaluate the relationship of delirium and risk factors in cardiology intensive care unit (ICU) patients with the nursing workload. BACKGROUND: Delirium is a common syndrome in patients with cardiac problems. The risk factors causing delirium and the presence and type of delirium affect the nurse workload and patient care quality adversely. DESIGN: This cross-sectional study was conducted with 133 patients staying at the cardiology ICU of a university hospital between January 5 and March 31, 2017...
March 31, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29600940/the-burden-of-systemic-juvenile-idiopathic-arthritis-for-patients-and-caregivers-an-international-survey-and-retrospective-chart-review
#10
Susan Shenoi, Gerd Horneff, Michal Cidon, Athimalaipet V Ramanan, Yukiko Kimura, Pierre Quartier, Ivan Foeldvari, Andrew Zeft, Kathleen G Lomax, Jill Gregson, Tineke Abma, Sarah Campbell-Hill, Jeffrey Weiss, Dony Patel, Nina Marinsek, Nico Wulffraat
OBJECTIVES: To investigate the burden of systemic juvenile idiopathic arthritis (SJIA) on health-related quality of life (HRQOL) and resource use of patients and caregivers (families) on biologic therapy. METHODS: This international study assessed SJIA burden in patients on biologics, using a caregiver questionnaire and retrospective chart review. Validated measures included: Child Health Questionnaire Parent-Form 50 (CHQ-PF50), 36-Item Short-Form Health Survey (SF-36v2) and Work Productivity and Activity Impairment questionnaire: Specific Health Problem (WPAI:SHP)...
March 21, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29569403/generalizability-of-the-findings-from-a-randomized-controlled-trial-of-a-web-based-substance-use-disorder-intervention
#11
Ryoko Susukida, Rosa M Crum, Elizabeth A Stuart, Ramin Mojtabai
BACKGROUND AND OBJECTIVES: There is growing concern regarding the generalizability of findings from randomized controlled trials (RCTs) of interventions for substance use disorders (SUDs). This study used a selection model approach to assess and improve the generalizability of an evaluation for a web-based SUD intervention by making the trial sample resemble the target population. METHODS: The sample of the web-based SUD intervention (Therapeutic Education System vs...
March 23, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29556676/blood-pressure-and-collateral-circulation-in-acute-ischemic-stroke
#12
A Wufuer, P Mijiti, R Abudusalamu, H Dengfeng, C Jian, M Jianhua, Z Xiaoning
BACKGROUND: This study aimed to evaluate the effect of different blood pressure (BP) parameters on the collateral circulation in a retrospective cohort of patients with acute ischemic stroke and ipsilateral internal carotid artery (ICA) occlusion. METHODS: The degree of intracranial collaterals was graded according to the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) Collateral Flow Grading System...
March 20, 2018: Herz
https://www.readbyqxmd.com/read/29536745/astaxanthin-effectiveness-in-preventing-multiple-sclerosis-in-animal-model
#13
S Bidaran, A R Ahmadi, P Yaghmaei, M H Sanati, A Ebrahim-Habibi
OBJECTIVE: The aim of the present study was to reveal the effect of therapeutic and prophylactic potential of astaxanthin in experimental autoimmune encephalomyelitis (EAE) as an acceptable model for the study of multiple sclerosis (MS). BACKGROUND: Astaxanthin has powerful antioxidant activities as well as several essential biological functions while multiple sclerosis prevention is highly regarded by researchers. METHODS: The astaxanthin potential in prevention of multiple sclerosis was examined in the chronic model of experimental autoimmune encephalomyelitis (EAE) by using female C57BL/6 mice induced with oligodendrocyte glycoprotein (MOG)...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29534906/initial-surgical-experience-following-implementation-of-lung-cancer-screening-at-an-urban-safety-net-hospital
#14
Juan A Muñoz-Largacha, Katrina A Steiling, Hasmeena Kathuria, Marjory Charlot, Carmel Fitzgerald, Kei Suzuki, Virginia R Litle
BACKGROUND: Safety net hospitals provide care mostly to low-income, uninsured, and vulnerable populations, in whom delays in cancer screening are established barriers. Socioeconomic barriers might pose important challenges to the success of a lung cancer screening program at a safety net hospital. We aimed to determine screening follow-up compliance, rates of diagnostic and treatment procedures, and the rate of cancer diagnosis in patients classified as category 4 by the Lung CT Screening Reporting and Data System (Lung-RADS 4)...
February 9, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29529637/early-improvement-in-pain-and-functional-outcome-but-not-quality-of-life-after-surgery-for-metastatic-long-bone-disease
#15
Anas Nooh, Krista Goulding, Marc H Isler, Sophie Mottard, Annie Arteau, Norbert Dion, Robert Turcotte
BACKGROUND: Bone metastases represent the most frequent cause of cancer-related pain, affecting health-related quality of life and creating a substantial burden on the healthcare system. Although most bony metastatic lesions can be managed nonoperatively, surgical management can help patients reduce severe pain, avoid impending fracture, and stabilize pathologic fractures. Studies have demonstrated functional improvement postoperatively as early as 6 weeks, but little data exist on the temporal progress of these improvements or on the changes in quality of life over time as a result of surgical intervention...
March 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29523720/impact-of-emergency-department-surge-and-end-of-shift-on-patient-workup-and-treatment-prior-to-referral-to-internal-medicine-a-health-records-review
#16
Valerie Charbonneau, Edmund Kwok, Loree Boyle, Ian G Stiell
BACKGROUND: The goal of this study was to determine if ED surge and end-of-shift assessment of patients affect the extent of diagnostic tests, therapeutic interventions and accuracy of diagnosis prior to referral to internal medicine. METHODS: This study was a health records review of consecutive patients referred to the internal medicine service with an ED diagnosis of heart failure, chronic obstructive pulmonary disease (COPD) or sepsis starting 1 December 2013 until 100 cases for each condition had been obtained...
March 9, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29483071/evaluating-the-effect-of-a-web-based-e-learning-tool-for-health-professional-education-on-clinical-vancomycin-use-comparative-study
#17
Stuart Evan Bond, Shelley P Crowther, Suman Adhikari, Adriana J Chubaty, Ping Yu, Jay P Borchard, Craig Steven Boutlis, Wilfred Winston Yeo, Spiros Miyakis
BACKGROUND: Internet-based learning for health professional education is increasing. It offers advantages over traditional learning approaches, as it enables learning to be completed at a time convenient to the user and improves access where facilities are geographically disparate. We developed and implemented the Vancomycin Interactive (VI) e-learning tool to improve knowledge on the clinical use of the antibiotic vancomycin, which is commonly used for treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA)...
February 26, 2018: JMIR Medical Education
https://www.readbyqxmd.com/read/29473384/five-year-prospective-study-on-cardiovascular-events-in-patients-with-erectile-dysfunction-and-hypotestosterone
#18
Rosanna Iacona, Vito Bonomo, Mariaconcetta Di Piazza, Angela Sansone, Manuela Usala, Salvatore Novo, Carlo Pavone
OBJECTIVE: Testosterone levels play a role in cardiac and vascular pathology. In the present study we investigated the prognostic significance of this hormone for cardiovascular outcome, in a 5-year follow-up. MATERIALS AND METHODS: Our cohort included 802 adult subjects, from 40 to 80 years. Patients were excluded if they had a past history of peripheral or coronary artery disease, and revascularization. A blood sample was drawn to valuate testosterone level, and we considered normal testosterone levels 300 ng/dl...
December 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/29469547/workload-and-severity-of-illness-of-patients-on-intensive-care-units-with-available-intermediate-care-units-a-multicentre-cohort-study
#19
Uwe Hamsen, Rolf Lefering, Christian Fisahn, Thomas A Schildhauer, Chistian Waydhas
BACKGROUND: Intermediate care units (IMCU) are established in many hospitals to better match the requirements of patient care with respect to their personnel, equipment and other resources. This should relieve intensive care unit (ICU) capacities for more severely ill patients and reduce readmissions to ICU. This study was conducted to investigate the effects of IMCU use on ICU populations. METHODS: This is a retrospective analysis of the German National Registry of Intensive Care from the years 2000 to 2010...
February 15, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29460418/reliability-of-histologic-assessment-in-patients-with-eosinophilic-oesophagitis
#20
M J Warners, C A Ambarus, A J Bredenoord, J Verheij, G Y Lauwers, J C Walsh, D A Katzka, S Nelson, T van Viegen, G T Furuta, S K Gupta, L Stitt, G Zou, C E Parker, L M Shackelton, G R D Haens, W J Sandborn, E S Dellon, B G Feagan, M H Collins, V Jairath, R K Pai
BACKGROUND: The validity of the eosinophilic oesophagitis (EoE) histologic scoring system (EoEHSS) has been demonstrated, but only preliminary reliability data exist. AIM: Formally assess the reliability of the EoEHSS and additional histologic features. METHODS: Four expert gastrointestinal pathologists independently reviewed slides from adult patients with EoE (N = 45) twice, in random order, using standardised training materials and scoring conventions for the EoEHSS and additional histologic features agreed upon during a modified Delphi process...
February 20, 2018: Alimentary Pharmacology & Therapeutics
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