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https://www.readbyqxmd.com/read/28819204/prognostic-factors-and-outcomes-of-unplanned-extubation
#1
Chien-Ming Chao, Mei-I Sung, Kuo-Chen Cheng, Chih-Cheng Lai, Khee-Siang Chan, Ai-Chin Cheng, Shu-Chen Hsing, Chin-Ming Chen
This study investigated the prognostic factors and outcomes of unplanned extubation (UE) in patients in a medical center's 6 intensive care units (ICUs) and calculated their mortality risk. We retrospectively reviewed the medical records of all adult patients in Chi Mei Medical Center who underwent UE between 2009 and 2015. During the study period, there were 305 episodes of UE in 295 ICU patients (men: 199 [67.5%]; mean age: 65.7 years; age range: 18-94 years). The mean Acute Physiology and Chronic Health Evaluation (APACHE) II score was 16...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28815014/the-relationship-between-intolerance-of-uncertainty-in-chiropractic-students-and-their-treatment-intervention-choices
#2
Stanley I Innes, Charlotte Leboeuf-Yde, Bruce F Walker
BACKGROUND: Psychological factors, such as intolerance of uncertainty (IU), have been shown to impact on the quality of medical care. However, this psychological measure has not been studied in the chiropractic profession. Our objective was to investigate if higher levels of IU in chiropractic students were related to poor choices of management in specific clinical scenarios. Also, we sought to investigate if levels of IU were related to students' intentions to adopt a prescriptive chiropractic technique system and evaluate their levels of self-belief...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28769143/zonulin-a-potential-marker-of-intestine-injury-in-newborns
#3
Anna Tarko, Anna Suchojad, Marta Michalec, Małgorzata Majcherczyk, Aniceta Brzozowska, Iwona Maruniak-Chudek
INTRODUCTION: Zonulin (ZO), a new diagnostic biomarker of intestinal permeability, was tested in newborns presenting symptoms of infection and/or inflammation of the gut or being at risk of intestinal pathology. MATERIAL AND METHODS: Serum ZO was assessed in 81 newborns diagnosed with sepsis, necrotizing enterocolitis (NEC), rotavirus infection, and gastroschisis, also in extremely low gestational age babies, and in controls (healthy newborns). ZO concentration was compared to C-reactive protein (CRP) and procalcitonin (PCT) values, leucocyte and platelet count, basic demographic data, and the value of the Neonatal Therapeutic Intervention Scoring System (NTISS)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28760300/first-line-therapeutic-strategies-for-myelodysplastic-syndromes
#4
REVIEW
Valeria Santini
The precise diagnostic tests and subsequent prognostic stratification for patients with myelodysplastic syndrome (MDS) are often cumbersome, yet they are the basis of successful therapy. Diverse treatment options are available for these patients; however, the decisions in real-life are often not grounded on the available evidence. Although the International Prognostic Scoring System and revised International Prognostic Scoring System are still driving the medical approach to MDS patients, additional variables must be considered when therapeutic intervention is needed...
July 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28748406/therapeutic-effects-of-topical-tranexamic-acid-in-comparison-with-hydroquinone-in-treatment-of-women-with-melasma
#5
Najmolsadat Atefi, Behzad Dalvand, Mahammadreza Ghassemi, Golnaz Mehran, Amir Heydarian
INTRODUCTION: Few studies have focused on therapeutic as well as side effects of tranexamic acid (TXA) as a topical drug compared to other topical drugs in treating melasma. The present study aimed to assess and compare the beneficial therapeutic effects and also side effects of local TXA in comparison with hydroquinone in treating women with melasma. METHODS: This randomized double-blinded clinical trial was performed on 60 women who suffered from melasma and were referred to the skin disorders clinic at the Rasoul-e-Akram hospital in Tehran in 2015...
July 26, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28720052/the-effectiveness-of-various-interventions-versus-standard-stripping-in-patients-with-varicose-veins-in-terms-of-quality-of-life
#6
Christos Argyriou, Christos Papasideris, George A Antoniou, Efstratios Georgakarakos, Nikolaos Papanas, Miltos K Lazarides, George S Georgiadis
Purpose Lower limb varicose veins have a significant effect upon the quality of life and a considerable socioeconomic impact despite their relatively benign nature. The aim of this study is to compare the effects of various therapeutic strategies among patients with varicose veins to surgical ligation and vein stripping on the basis of quality of life. Methods PubMed/Medline and Scopus databases were systemically searched from 1 January 2000 until 23 December 2015 for studies reporting outcome on the quality of life of different treatment techniques for varicose veins...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28718038/reappraisal-of-staging-laparoscopy-for-patients-with-pancreatic-adenocarcinoma-a-contemporary-analysis-of-1001-patients
#7
Zhi Ven Fong, Donna Marie L Alvino, Carlos Fernández-Del Castillo, Winta T Mehtsun, Ilaria Pergolini, Andrew L Warshaw, David C Chang, Keith D Lillemoe, Cristina R Ferrone
BACKGROUND: Recent advances in imaging and the increasing use of neoadjuvant therapy puts the contemporary utility of staging laparoscopy for patients with pancreatic adenocarcinoma (PDAC) into question. This study aimed to develop a prognostic score to optimize prevention of an unnecessary laparotomy and minimize the rate for unnecessary laparoscopy. METHODS: Clinicopathologic data were evaluated for all patients undergoing surgical intervention for PDAC between 2001 and 2015, who were stratified into group 1 (2001-2008) and group 2 (2009-2014)...
July 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28707434/utility-of-digital-subtraction-angiography-based-collateral-evaluation-in-medically-treated-acute-symptomatic-basilar-artery-stenosis
#8
W-J Lee, K-H Jung, Y J Ryu, J-M Kim, S-T Lee, K Chu, M Kim, S K Lee, J-K Roh
BACKGROUND AND PURPOSE: Although a stroke from atherosclerosis in the basilar artery (BA) often presents with mild initial stroke severity, it has heterogeneous clinical courses. We investigated the efficacy of digital subtraction angiography (DSA)-based collateral perfusion evaluation in association with long-term outcomes of medically treated symptomatic basilar artery stenosis. METHODS: From a registry database of all consecutive patients with stroke, we included 98 medically treated patients (due to mild initial stroke severity) [National Institute of Health Stroke Scale (NIHSS) scores ≤ 4; symptomatic basilar artery stenosis, 70-99%] with available initial diagnostic DSA...
July 14, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28691435/clinical-and-public-health-implications-of-acute-and-early-hiv-detection-and-treatment-a-scoping-review
#9
Sarah E Rutstein, Jintanat Ananworanich, Sarah Fidler, Cheryl Johnson, Eduard J Sanders, Omar Sued, Asier Saez-Cirion, Christopher D Pilcher, Christophe Fraser, Myron S Cohen, Marco Vitoria, Meg Doherty, Joseph D Tucker
INTRODUCTION: The unchanged global HIV incidence may be related to ignoring acute HIV infection (AHI). This scoping review examines diagnostic, clinical, and public health implications of identifying and treating persons with AHI. METHODS: We searched PubMed, in addition to hand-review of key journals identifying research pertaining to AHI detection and treatment. We focused on the relative contribution of AHI to transmission and the diagnostic, clinical, and public health implications...
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28673612/central-and-systemic-c-type-natriuretic-peptide-are-both-reduced-in-parkinson-s-disease
#10
Zoe Woodward, Timothy C R Prickett, Eric A Espiner, Timothy J Anderson
INTRODUCTION: C-type Natriuretic Peptide is a neuropeptide widely expressed in the central nervous system including dopaminergic neurons projecting to basal ganglia. Previous work shows that concentrations of the peptide in cerebrospinal fluid are depressed in drug naïve PD subjects, decline over time and can be restored by doses of monoamine oxidase inhibitors that delay the need for levodopa. Whether plasma levels are similarly depressed in drug naïve subjects, or affected by dopaminergic drugs, is unknown...
June 27, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28662216/increased-dermal-collagen-bundle-alignment-in-systemic-sclerosis-is-associated-with-a-cell-migration-signature-and-role-of-arhgdib-in-directed-fibroblast-migration-on-aligned-ecms
#11
Lizhi Cao, Robert Lafyatis, Linda C Burkly
Systemic sclerosis (SSc) is a devastating disease affecting the skin and internal organs. Dermal fibrosis manifests early and Modified Rodnan Skin Scores (MRSS) correlate with disease progression. Transcriptomics of SSc skin biopsies suggest the role of the in vivo microenvironment in maintaining the pathological myofibroblasts. Therefore, defining the structural changes in dermal collagen in SSc patients could inform our understanding of fibrosis pathogenesis. Here, we report a method for quantitative whole-slide image analysis of dermal collagen from SSc patients, and our findings of more aligned dermal collagen bundles in diffuse cutaneous SSc (dcSSc) patients...
2017: PloS One
https://www.readbyqxmd.com/read/28657379/a-new-imaging-technique-for-assessment-of-the-effectiveness-of-long-pulse-nd-yag-532-nm-laser-in-treatment-of-facial-port-wine-stain
#12
Murtadha Hashim Al-Janabi, Noor Taha Ismaeel Ali, Karrar Dheiaa Mohammed, Muhsin A Al-Dhalimi, Sahib Neamh Abdul Wahid
BACKGROUND: PWS is a vascular malformation presented at birth and associated with a psychological problem to the patients. Many types the laser systems were used to solve this problem. AIM OF THE STUDY: to assess the efficacy of long-pulsed Nd:YAG 532 nm for the treatment of port wine stain both clinically and by imaging technique. PATIENTS AND METHODS: This is an Interventional therapeutic clinical study for the treatment of facial port-twine stain with long-pulsed, 532nm, Nd:YAG laser...
June 28, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28651935/derivation-and-validation-of-a-novel-risk-score-for-safe-discharge-after-acute-lower-gastrointestinal-bleeding-a-modelling-study
#13
Kathryn Oakland, Vipul Jairath, Raman Uberoi, Richard Guy, Lakshmana Ayaru, Neil Mortensen, Mike F Murphy, Gary S Collins
BACKGROUND: Acute lower gastrointestinal bleeding is a common reason for emergency hospital admission, and identification of patients at low risk of harm, who are therefore suitable for outpatient investigation, is a clinical and research priority. We aimed to develop and externally validate a simple risk score to identify patients with lower gastrointestinal bleeding who could safely avoid hospital admission. METHODS: We undertook model development with data from the National Comparative Audit of Lower Gastrointestinal Bleeding from 143 hospitals in the UK in 2015...
June 23, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28616424/evaluation-of-1-year-old-children-development-in-isfahan-city-and-its-effective-factors-using-ages-and-stages-questionnaire-in-2014
#14
Mehri Rejali, Soheila Pahlavni, Akbar Hassanzadeh
BACKGROUND AND AIMS: Attention to the development of children as the future generation that leads to the upbringing of productive human resources is an important subject. Development has dimensions that a child should acquire the skills related to them in proper age. Otherwise, he may be affected by developmental delays. There are different factors influencing children's developmental delays and this study is carried out to evaluate the developmental conditions of 1-year-old children in the Isfahan and its effective factors...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28606661/effects-of-virtual-reality-training-using-xbox-kinect-on-motor-function-in-stroke-survivors-a-preliminary-study
#15
Dae-Sung Park, Do-Gyun Lee, Kyeongbong Lee, GyuChang Lee
BACKGROUND: Although the Kinect gaming system (Microsoft Corp, Redmond, WA) has been shown to be of therapeutic benefit in rehabilitation, the applicability of Kinect-based virtual reality (VR) training to improve motor function following a stroke has not been investigated. This study aimed to investigate the effects of VR training, using the Xbox Kinect-based game system, on the motor recovery of patients with chronic hemiplegic stroke. METHODS: This was a randomized controlled trial...
June 9, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28590841/rapid-prediction-of-hematologic-acute-radiation-syndrome-in-radiation-injury-patients-using-peripheral-blood-cell-counts
#16
M Port, B Pieper, T Knie, H Dörr, A Ganser, D Graessle, V Meineke, M Abend
Rapid clinical triage of radiation injury patients is essential for determining appropriate diagnostic and therapeutic interventions. We examined the utility of blood cell counts (BCCs) in the first three days postirradiation to predict clinical outcome, specifically for hematologic acute radiation syndrome (HARS). We analyzed BCC test samples from radiation accident victims (n = 135) along with their clinical outcome HARS severity scores (H1-4) using the System for Evaluation and Archiving of Radiation Accidents based on Case Histories (SEARCH) database...
August 2017: Radiation Research
https://www.readbyqxmd.com/read/28572469/magnetic-resonance-imaging-mri-of-the-knee-as-an-outcome-measure-in-juvenile-idiopathic-arthritis-an-omeract-reliability-study-on-mri-scales
#17
Robert Hemke, Nikolay Tzaribachev, Charlotte M Nusman, Marion A J van Rossum, Mario Maas, Andrea S Doria
OBJECTIVE: There is increasing evidence that early therapeutic intervention improves longterm joint outcome in juvenile idiopathic arthritis (JIA). Given the existence of highly effective treatments, there is an urgent need for reliable and accurate measures of disease activity and joint damage in JIA. Our objective was to assess the reliability of 2 magnetic resonance imaging (MRI) scoring methods: the Juvenile Arthritis MRI Scoring (JAMRIS) system and the International Prophylaxis Study Group (IPSG) consensus score, for evaluating disease status of the knee in patients with JIA...
June 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28547319/systemic-inflammatory-response-syndrome-sirs-score-independently-predicts-poor-outcome-in-isolated-traumatic-brain-injury
#18
Tomas Jacome, Danielle Tatum
INTRODUCTION: Systemic inflammatory response syndrome (SIRS) is frequently observed after various types of acute cerebral injury and has been linked to clinical deterioration in non-traumatic brain injury (TBI). SIRS scores have also been shown to be predictive of length of stay and mortality in trauma patients. We aimed to determine the prognostic utility of SIRS present at admission in trauma patients with isolated TBI. METHODS: This was a 5-year retrospective cohort study of adults (≥18 years) with isolated TBI admitted to a Level II trauma center...
May 25, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28519244/neonatal-abstinence-syndrome-update-on-diagnostic-and-therapeutic-strategies
#19
Genny Raffaeli, Giacomo Cavallaro, Karel Allegaert, Enno Diederik Wildschut, Monica Fumagalli, Massimo Agosti, Dick Tibboel, Fabio Mosca
Substance use among pregnant women is a major public health issue. Both prescription opioid use and illicit opioid abuse have increased dramatically in recent years. Prolonged in utero drug exposure may result in neonatal abstinence syndrome (NAS), an acute multisystemic clinical entity that occurs in the first days of life. This syndrome is caused by abrupt discontinuation of fetal exposure to licit or illicit drugs chronically consumed by the mother during pregnancy and transmitted to the fetus through the placenta...
May 18, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28507011/influence-of-diet-in-multiple-sclerosis-a-systematic-review
#20
REVIEW
M José Bagur, M Antonia Murcia, Antonia M Jiménez-Monreal, Josep A Tur, M Mar Bibiloni, Gonzalo L Alonso, Magdalena Martínez-Tomé
Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Forty-seven articles met the inclusion criteria...
May 2017: Advances in Nutrition
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