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retained placenta

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https://www.readbyqxmd.com/read/29042604/placenta-specific1-plac1-is-a-potential-target-for-antibody-drug-conjugate-based-prostate-cancer-immunotherapy
#1
Mohammad-Reza Nejadmoghaddam, Amir-Hassan Zarnani, Ramin Ghahremanzadeh, Roya Ghods, Jafar Mahmoudian, Maryam Yousefi, Mahboobeh Nazari, Mohammad Hossein Ghahremani, Maryam Abolhasani, Ali Anissian, Morteza Mahmoudi, Rassoul Dinarvand
Our recent findings strongly support the idea of PLAC1 being as a potential immunotherapeutic target in prostate cancer (PCa). Here, we have generated and evaluated an anti-placenta-specific1 (PLAC1)-based antibody drug conjugate (ADC) for targeted immunotherapy of PCa. Prostate cancer cells express considerable levels of PLAC1. The Anti-PLAC1 clone, 2H12C12, showed high reactivity with recombinant PLAC1 and selectivity recognized PLAC1 in prostate cancer cells but not in LS180 cells, the negative control. PLAC1 binding induced rapid internalization of the antibody within a few minutes which reached to about 50% after 15 min and almost completed within an hour...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29032783/targeted-metabolomics-new-insights-into-pathobiology-of-retained-placenta-in-dairy-cows-and-potential-risk-biomarkers
#2
E Dervishi, G Zhang, R Mandal, D S Wishart, B N Ametaj
A targeted quantitative metabolomics approach was used to study temporal changes of serum metabolites in cows that normally released their fetal membranes and those that retained the placenta. We identified and measured serum concentrations of 128 metabolites including amino acids, acylcarnitines, biogenic amines, glycerophospholipids, sphingolipids and hexose at -8 and -4 weeks before parturition, during the week of retained placenta (RP) diagnosis, and at +4 and +8 weeks after parturition. In addition, we aimed at identifying metabolite signatures of pre-RP in the serum that might be used as predictive biomarkers for risk of developing RP in dairy cows...
October 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28987571/field-trial-of-2-calcium-supplements-on-early-lactation-health-and-production-in-multiparous-holstein-cows
#3
Antonia R Domino, Helen C Korzec, Jessica A A McArt
Our objectives were to measure serum Ca concentrations in the first 48 h postpartum in cows supplemented with oral Ca or subcutaneous Ca and nonsupplemented cows and evaluate the effect of these treatments on the incidence of metritis, displaced abomasum, mastitis, and early lactation disease (any of the diseases milk fever, retained placenta, metritis, or displaced abomasum), removal from the herd, pregnancy to first insemination, and average daily milk yield for the first 10 wk of lactation. We conducted 2 experiments on 1 commercial herd in New York State...
October 4, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28982025/pregnancy-associated-glycoproteins-in-cows-with-retained-fetal-membranes
#4
Reyhaneh Hooshmandabbasi, Holm Zerbe, Stefan Bauersachs, Noelita M de Sousa, Alois Boos, Karl Klisch
In cows, retained fetal membranes (RFM) are a major problem in reproduction. The timely detachment of fetal membranes after parturition requires well coordinated maturation processes in the placenta. One feature of placental maturation in cows is a prepartal decline in the number of binucleate trophoblast giant cells (BNC) in the fetal chorion. Pregnancy associated glycoproteins (PAGs) are a group of proteins, produced by trophoblast cells in artiodactyls. We studied aspects of PAG expression in cows with and without RFM...
September 25, 2017: Theriogenology
https://www.readbyqxmd.com/read/28980065/conservative-endovascular-management-of-retained-placenta-accreta-with-marked-vascularity-after-abortion-or-delivery
#5
Akihiro Takeda, Wataru Koike
OBJECTIVE: To report our experience on the value of transcatheter arterial embolization (TAE) or transcatheter arterial chemoembolization (TACE) for the uterus-preserving management of retained placenta accreta with marked vascularity after abortion or delivery. STUDY DESIGN: Thirty-eight consecutive women with retained placenta accreta were retrospectively analyzed over a 5-year period. When elevated levels of serum β-hCG (> 25 mIU/mL) were detected, TACE with dactinomycin was chosen for devascularization along with cytotoxic effects on active trophoblasts; in contrast, if the serum β-hCG level was low (≤ 25 mIU/mL), TAE was chosen...
October 4, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28952961/eating-and-rumination-activities-two-weeks-prepartum-to-one-month-postpartum-in-100-healthy-cows-and-cows-with-peripartum-diseases
#6
U Braun, H Buchli, M Hässig
Eating and rumination activities were investigated in 100 cows from 14 days prepartum to 30 days postpartum. All cows were clinically healthy at the start of the study. A pressure sensor incorporated into the noseband of a halter was used to record jaw movements, which allowed the quantification of the daily duration of eating and rumination, number of regurgitated cuds and number of chewing cycles per cud. The cows were retrospectively divided into 2 main groups healthy (n = 24) and ill cows (n = 76), and the latter were further divided into the following subgroups: cows with periparturient paresis (n = 12), retained placenta (n = 13), metritis (n = 17), primary ketosis (n = 19) and lameness (n = 6)...
October 2017: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/28941821/effect-of-group-size-and-health-status-on-behavior-and-feed-intake-of-multiparous-dairy-cows-in-early-lactation
#7
Margit Bak Jensen, Kathryn L Proudfoot
Dairy cows in early lactation are often housed in a large group, where they may have to compete for access to feed and space. However, a cow's ability to compete may be impaired due to production disease, and housing in a small group with minimal competition may be beneficial for cow welfare. The aim of this study was to investigate the effect of group size and health on social and feeding behavior of cows during the first 3 d after introduction to a new group. Data included 54 multiparous Holstein-Friesian cows that were moved from an individual maternity pen and individually joined an existing group pen for 6 (N6) or 24 cows (N24) on d 4 after calving...
September 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28939480/title-hysteroscopic-removal-of-retained-products-of-conception-implanted-over-a-focal-area-of-adenomyosis-a-case-report
#8
Luis Alonso, Laura Nieto, Jose Carugno
STUDY OBJECTIVE: To describe a technique for hysteroscopic removal of retained products of conception (RPOC) implanted over an area of adenomyosis. DESIGN: Case report (Canadian Task Force classification III) SETTING: Retained products of conception is an unfortunate complication that may occur after resolution of a normal pregnancy, being more common after early pregnancy termination or spontaneous miscarriage. (1) Immediate consequences of RPOC include persistent vaginal bleeding, abdominal pain, pelvic infection, fever and dilated cervix...
September 19, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28928192/a-pragmatic-group-sequential-placebo-controlled-randomised-trial-to-determine-the-effectiveness-of-glyceryl-trinitrate-for-retained-placenta-got-it-a-study-protocol
#9
Fiona C Denison, John Norrie, Julia Lawton, Jane E Norman, Graham Scotland, Gladys C McPherson, Alison McDonald, Mark Forrest, Jemma Hudson, Jane Brewin, Mathilde Peace, Cynthia Clarkson, Sheonagh Brook-Smith, Susan Morrow, Nina Hallowell, Laura Hodges, Kathryn F Carruthers
INTRODUCTION: A retained placenta is diagnosed when the placenta is not delivered following delivery of the baby. It is a major cause of postpartum haemorrhage and treated by the operative procedure of manual removal of placenta (MROP). METHODS AND ANALYSIS: The aim of this pragmatic, randomised, placebo-controlled, double-blind UK-wide trial, with an internal pilot and nested qualitative research to adjust strategies to refine delivery of the main trial, is to determine whether sublingual glyceryl trinitrate (GTN) is (or is not) clinically and cost-effective for (medical) management of retained placenta...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28919681/seroprevalence-of-bovine-viral-diarrhea-virus-in-crossbred-dairy-cattle-in-bangladesh
#10
Mohammed Arif Uddin, A S M Lutful Ahasan, Kamrul Islam, Md Zohorul Islam, Altaf Mahmood, Ariful Islam, Kazi Muhammad Fakhrul Islam, Abdul Ahad
AIM: The study was conducted to determine the seroprevalence of bovine viral diarrhea virus (BVDV) and hematological features in crossbred dairy cattle in Chittagong, Bangladesh. MATERIALS AND METHODS: The antibody against BVDV in crossbred dairy cattle serum was detected by indirect enzyme-linked immunosorbent assay. The association of different categorical variables in the prevalence of BVDV has been studied. Blood samples were collected and analyzed to know the hematological variations in the study population...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28903871/prevalence-and-risk-factors-for-transition-period-diseases-in-grazing-dairy-cows-in-brazil
#11
Rolnei R Daros, Maria J Hötzel, Jose A Bran, Stephen J LeBlanc, Marina A G von Keyserlingk
The aim of this cross-sectional study was to describe the incidence risk of dystocia, retained placenta (RP), pathological recumbence (down cow), the prevalence of metritis and subclinical ketosis (SCK), and the risk factors for SCK, metritis, and RP in grazing dairy herds in Southern Brazil. Fifty-three herds were visited 2-6 times from February to October of 2015. Body condition score (BCS), breed, days in milk (DIM), parity and disease status were recorded for each cow that was between 3 and 21 DIM at the time of the visits...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28875743/different-routes-and-forms-of-uterotonics-for-treatment-of-retained-placenta-methodological-issues
#12
Ahmed M Abbas
No abstract text is available yet for this article.
September 6, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28865850/validation-of-genomic-predictions-for-wellness-traits-in-us-holstein-cows
#13
Anthony K McNeel, Brenda C Reiter, Dan Weigel, Jason Osterstock, Fernando A Di Croce
The objective of this study was to evaluate the efficacy of wellness trait genetic predictions in commercial herds of US Holstein cows from herds that do not contribute phenotypic information to the evaluation. Tissue samples for DNA extraction were collected from more than 3,400 randomly selected pregnant Holstein females in 11 herds and 2 age groups (69% nulliparous, 31% primiparous) approximately 30 to 60 d before their expected calving date. Lactation records from cows that calved between September 1, 2015, and December 31, 2015, were included in the analysis...
November 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28859955/human-placentophagy-a-review
#14
REVIEW
Alex Farr, Frank A Chervenak, Laurence B McCullough, Rebecca N Baergen, Amos Grünebaum
Placentophagy or placentophagia, the postpartum ingestion of the placenta, is widespread among mammals; however, no contemporary human culture incorporates eating placenta postpartum as part of its traditions. At present, there is an increasing interest in placentophagy among postpartum women, especially in the United States. The placenta can be eaten raw, cooked, roasted, dehydrated, or encapsulated or through smoothies and tinctures. The most frequently used preparation appears to be placenta encapsulation after steaming and dehydration...
August 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28826360/placental-location-postpartum-hemorrhage-and-retained-placenta-in-women-with-a-previous-cesarean-section-delivery-a-prospective-cohort-study
#15
Johanna Belachew, Karin Eurenius, Ajlana Mulic-Lutvica, Ove Axelsson
OBJECTIVE: Women previously giving birth with cesarean section have an increased risk of postpartum hemorrhage (PPH) and retained placenta. The objective of this study was to determine if anterior placental location increased the risk of PPH and retained placenta in such women. MATERIALS AND METHODS: We performed a prospective cohort study on 400 women with cesarean section delivery in a previous pregnancy. Ultrasound examinations were performed at gestational week 28-30, and placental location, myometrial thickness, and three-dimensional vascularization index (VI) were recorded...
August 22, 2017: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/28800671/-outcomes-of-planned-out-of-hospital-and-low-risk-hospital-births-in-lower-saxony
#16
Antje Petersen, Lea-Marie Köhler, Christiane Schwarz, Bernhard Vaske, Mechthild M Gross
Introduction Internationally, there is debate on the safety of different birth settings inside and outside of hospitals. Low-risk women in Germany can choose where they give birth, and out-of-hospital births are especially necessary in regions lacking infrastructure. To date, national studies are required. Materials and Methods We investigated planned out-of-hospital (OH) and hospital births in Lower Saxony, Germany, in 2005. Women with a singleton fetus in the vertex position were included once they reached 34+0 gestational weeks...
August 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28782399/use-of-bakri-balloon-tamponade-bbt-for-conservative-management-of-postpartum-haemorrhage-a-tertiary-referral-centre-case-series
#17
Manisha Mathur, Qiu Ju Ng, Shephali Tagore
The aim of this study was to investigate the efficacy of the Bakri balloon in the management of PPH. This was a retrospective review of 49 patients, who had Bakri balloon inserted for PPH in KK Hospital between April 2013 and December 2015. The main outcome measure was achievement of haemostasis by Bakri balloon tamponade (BBT). Our success rate was 81.6%. Out of the nine failures (18.0%), five (55.6%) had subtotal hysterectomies and four (44.4%) had total hysterectomies. The causes of PPH in these nine women were unsuspected or foci of placenta accreta (55...
August 6, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28750937/castor-oil-for-induction-of-labor-in-post-date-pregnancies-a-randomized-controlled-trial
#18
Ronit Gilad, Hagit Hochner, Bella Savitsky, Shay Porat, Drorith Hochner-Celnikier
BACKGROUND: Castor oil is a substance used for labor induction in an inpatient setting. However, its efficacy as an agent for the induction of labor, for post-date pregnancies in an outpatient setup is unknown. OBJECTIVE: Efficacy of castor oil as an agent for the induction of labor, for post-date pregnancies in outpatient settings. METHODS: Eighty-one women with a low-risk post-date singleton pregnancy with a Bishop score≤7, without effective uterine contractions were randomized to the intervention, 60ml of castor oil, or the control, 60ml of sun-flower oil...
July 24, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28733576/mait-cells-accumulate-in-placental-intervillous-space-and-display-a-highly-cytotoxic-phenotype-upon-bacterial-stimulation
#19
Martin Solders, Laia Gorchs, Tom Erkers, Anna-Carin Lundell, Silvia Nava, Sebastian Gidlöf, Eleonor Tiblad, Isabelle Magalhaes, Helen Kaipe
During pregnancy, the maternal immune system must tolerate the developing foetus, and yet retain a potent antimicrobial response to prevent infections. Mucosal associated invariant T (MAIT) cells recognize microbial-derived vitamin B metabolites presented on the MR1 molecule, but their presence and function at the foetal-maternal interface is not known. We here isolated mononuclear cells from paired samples of peripheral blood (PB), intervillous blood (IVB), and decidua parietalis (DP) following uncomplicated term pregnancies...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28731581/the-inherited-risk-of-retained-placenta-a-population-based-cohort-study
#20
Margit Endler, Sven Cnattingius, Michaela Granfors, Anna-Karin Wikström
OBJECTIVE: To investigate whether retained placenta in the first generation is associated with an increased risk of retained placenta in the second generation. DESIGN: Population-based cohort study. SETTING: Sweden. POPULATION: Using linked generational data from the Swedish Medical Birth Register 1973-2012, we identified 494,000 second generation births with information on the birth of the mother (first generation index birth)...
July 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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