Edward J Saunders, Tokhir Dadaev, Mark N Brook, Sarah Wakerell, Koveela Govindasami, Reshma Rageevakumar, Nafisa Hussain, Andrea Osborne, Diana Keating, Artitaya Lophatananon, Kenneth R Muir, Burcu F Darst, David V Conti, Christopher A Haiman, Antonis C Antoniou, Rosalind A Eeles, Zsofia Kote-Jarai
BACKGROUND: Prostate cancer (PrCa) is a substantial cause of mortality among men globally. Rare germline mutations in BRCA2 have been validated robustly as increasing risk of aggressive forms with a poorer prognosis; however, evidence remains less definitive for other genes. OBJECTIVE: To detect genes associated with PrCa aggressiveness, through a pooled analysis of rare variant sequencing data from six previously reported studies in the UK Genetic Prostate Cancer Study (UKGPCS)...
March 7, 2024: European Urology Oncology