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https://www.readbyqxmd.com/read/28719613/visual-detection-of-brucella-in-bovine-biological-samples-using-dna-activated-gold-nanoparticles
#1
Dheeraj Pal, Nongthombam Boby, Satish Kumar, Gurpreet Kaur, Syed Atif Ali, Julien Reboud, Sameer Shrivastava, Praveen K Gupta, Jonathan M Cooper, Pallab Chaudhuri
Brucellosis is a bacterial disease, which, although affecting cattle primarily, has been associated with human infections, making its detection an important challenge. The existing gold standard diagnosis relies on the culture of bacteria which is a lengthy and costly process, taking up to 45 days. New technologies based on molecular diagnosis have been proposed, either through dip-stick, immunological assays, which have limited specificity, or using nucleic acid tests, which enable to identify the pathogen, but are impractical for use in the field, where most of the reservoir cases are located...
2017: PloS One
https://www.readbyqxmd.com/read/28718050/dissolving-microneedle-patches-for-dermal-vaccination
#2
REVIEW
M Leone, J Mönkäre, J A Bouwstra, G Kersten
The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin. The development of microneedles is crucial to take advantage of the skin immunization and simultaneously to overcome problems related to vaccination by conventional needles (e.g. pain, needle-stick injuries or needle re-use). This review focuses on dissolving microneedles that after penetration into the skin dissolve releasing the encapsulated antigen. The microneedle patch fabrication techniques and their challenges are discussed as well as the microneedle characterization methods and antigen stability aspects...
July 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28716771/an-intervention-using-gamification-to-increase-human-immunodeficiency-virus-and-sexually-transmitted-infection-screening-among-young-men-who-have-sex-with-men-in-california-rationale-and-design-of-stick-to-it
#3
Christopher M Mejia, Daniel Acland, Raluca Buzdugan, Reva Grimball, Lauren Natoli, Mark R McGrath, Jeffrey D Klausner, Sandra I McCoy
BACKGROUND: In the United States, young men who have sex with men (YMSM) remain disproportionately affected by human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). Although routine HIV/STI screening is pivotal to the timely diagnosis of HIV and STIs, initiation of appropriate treatment, and reduced onward disease transmission, repeat screening is underused. Novel interventions that incorporate elements of games, an approach known as gamification, have the potential to increase routinization of HIV/STI screening among YMSM...
July 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28713447/knowledge-about-blood-borne-pathogens-and-the-prevalence-of-needle-stick-injuries-among-medical-students-in-serbia
#4
Vuk Marusic, Ljiljana Markovic-Denic, Olivera Djuric, Dragana Protic, Emilija Dubljanin-Raspopovic
INTRODUCTION: Medical students are mainly exposed to needle stick and sharp object injuries in the course of their clinical activities during studying. They are at high risk due to their undeveloped skills, restricted clinical experience, lack of knowledge and risk perception. The objectives of this study were to determine the prevalence of needle stick injuries of the fourth and final year medical students, and to estimate their knowledge about blood-borne pathogens disease transmission and standard precautions...
September 2017: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/28712173/surgical-site-infection-in-orthopaedic-implants-and-its-common-bacteria-with-their-sensitivities-to-antibiotics-in-open-reduction-internal-fixation
#5
Muhammad Qaisar Shah, Muhammad Shoib Zardad, Alamzeb Khan, Sajjad Ahmed, Abdus Saboor Awan, Taj Mohammad
BACKGROUND: Surgical site infection in orthopaedic implants is a major problem, causing long hospital stay, cost to the patient and is a burden on health care facilities. It increases rate of nonunion, osteomyelitis, implant failure, sepsis, multiorgan dysfunction and even death. Surgical site infection is defined as pain, erythema, swelling and discharge from wound site. Surgical site infection in orthopaedic implants is more challenging to the treating orthopaedic surgeon as the causative organism is protected by a biofilm over the implant's surface...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28711064/methane-dissociation-on-ni-111-a-seven-dimensional-to-nine-dimensional-quantum-dynamics-study
#6
Xiangjian Shen, Zhaojun Zhang, Dong H Zhang
As one benchmark system of CH4 dissociation on the Ni(111) surface, it is of great significance to explore the role of each degree of freedom (DOF) of reactant CH4 in its first C-H bond dissociation from quantum dynamics simulations. Here, the influence of the CH stretching DOF of methyl limited in C3v symmetry is quantitatively investigated as well as the important role of azimuth. We calculated the sticking probabilities, S0, of ground state (GS) CH4 dissociation on a rigid Ni(111) surface by performing some seven-dimensional to nine-dimensional (9D) quantum dynamics simulations based on one highly accurate and fifteen-dimensional (15D) ab initio potential energy surface which we recently developed...
July 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28709275/nonequilibrium-dynamics-of-a-pure-dry-friction-model-subjected-to-colored-noise
#7
Paul M Geffert, Wolfram Just
We investigate the impact of noise on a two-dimensional simple paradigmatic piecewise-smooth dynamical system. For that purpose, we consider the motion of a particle subjected to dry friction and colored noise. The finite correlation time of the noise provides an additional dimension in phase space, causes a nontrivial probability current, and establishes a proper nonequilibrium regime. Furthermore, the setup allows for the study of stick-slip phenomena, which show up as a singular component in the stationary probability density...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708417/association-of-antibiotics-airway-microbiome-and-inflammation-in-infants-with-cystic-fibrosis
#8
Jessica E Pittman, Kristine M Wylie, Kathryn Akers, Gregory A Storch, Joseph Hatch, Jane Quante, Katherine B Frayman, Nadeene Clarke, Miriam Davis, Stephen M Stick, Graham L Hall, Gregory Montgomery, Sarath Ranganathan, Stephanie D Davis, Thomas W Ferkol
RATIONALE: The underlying defect in the cystic fibrosis (CF) airway leads to defective mucociliary clearance and impaired bacterial killing, resulting in endobronchial infection and inflammation that contributes to progressive lung disease. Little is known about the respiratory microbiota in the early CF airway and its relationship to inflammation. OBJECTIVES: To examine the bacterial microbiota and inflammatory profiles in bronchoalveolar lavage fluid and oropharyngeal secretions in infants with CF...
July 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28704560/performance-characteristics-of-finger-stick-dried-blood-spots-dbs-on-the-determination-of-human-immunodeficiency-virus-hiv-treatment-failure-in-a-pediatric-population-in-mozambique
#9
Joy Chang, Amina de Sousa, Jennifer Sabatier, Mariamo Assane, Guoqing Zhang, Dulce Bila, Paula Vaz, Charity Alfredo, Loide Cossa, Nilesh Bhatt, Emilia H Koumans, Chunfu Yang, Emilia Rivadeneira, Ilesh Jani, James C Houston
Quantitative plasma viral load (VL) at 1000 copies /mL was recommended as the threshold to confirm antiretroviral therapy (ART) failure by the World Health Organization (WHO). Because of ongoing challenges of using plasma for VL testing in resource-limited settings (RLS), especially for children, this study collected 717 DBS and paired plasma samples from children receiving ART ≥1 year in Mozambique and compared the performance of DBS using Abbott's VL test with a paired plasma sample using Roche's VL test...
2017: PloS One
https://www.readbyqxmd.com/read/28703174/super-stick-super-quick
#10
(no author information available yet)
New Clearfil Universal Bond Quick (UBQ) from Kuraray Noritake works almost instantly, delivering optimum results without the need to wait. Clearfil UBQ comprises new rapid bond technology, allowing the dental care professional to apply and proceed to the drying stage immediately - no more waiting!
June 9, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28699628/the-effects-of-partial-sleep-restriction-and-altered-sleep-timing-on-olfactory-performance
#11
J McNeil, G Forest, L J Hintze, J-F Brunet, É Doucet
Olfaction can increase the drive to eat and may partially explain the consistent increases in energy intake (EI) following sleep restriction. We investigated the effects of 50% sleep restriction with altered sleep timing on olfactory performance. We also evaluated whether changes (Δ) in olfactory performance were associated with Δ24 h EI. Twelve men and six women (age: 23±4 years; BMI: 23±3 kg/m(2)) completed three randomized cross-over conditions: habitual sleep duration, 50% sleep restriction with advanced wake-time, and 50% sleep restriction with delayed bedtime...
July 12, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28697597/core-assisted-formation-of-porphyrin-j-aggregates-in-ph-sensitive-polyelectrolyte-microcapsules-followed-by-fluorescence-lifetime-imaging-microscopy
#12
Vanda Vaz Serra, Nuno G B Neto, Suzana M Andrade, Silvia M B Costa
A strategy assisted by an inorganic template was developed to promote the organized self-assembly of meso-(tetrakis)-(p-sulfonatophenyl)porphyrin (TSPP) on pH sensitive core-shell polyelectrolyte microcapsules (PECs) of poly(styrene sulfonate) (PSS) and poly(allylamine hydrochloride) (PAH). A key feature of this strategy is the use of template CaCO3 microparticles as a nucleation site endorsing inside-outside directional growth of porphyrin aggregates. Using this approach, TSPP self-assembly in positively charged PECs with CaCO3 (PAH/PSS)2PAH as a sequence of layers was successfully achieved using pH mild conditions (pH 3)...
July 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28692504/the-effect-of-external-approach-septoplasty-on-olfactory-function
#13
Bilge Türk, Meltem Akpinar, Aytuğ Altundağ, Mehtap Özkahraman Kirik, Özlem Ünsal, Berna Uslu Coşkun
OBJECTIVE: Septal deviation-induced nasal obstruction is frequently accompanied by hyposmia. The aim of this study was to evaluate the effect of external approach septoplasty on olfactory function. METHODS: Thirty patients (23 males, 7 females) who had external approach septoplasty were included in the study. The age interval was 18 to 60 years (mean 33±12 years). All subjects had olfactory function and acoustic rhinometry tests in both the pre- and postoperative periods (mean interval 6 weeks ± 3 weeks)...
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28690424/generating-subtour-elimination-constraints-for-the-tsp-from-pure-integer-solutions
#14
Ulrich Pferschy, Rostislav Staněk
The traveling salesman problem (TSP) is one of the most prominent combinatorial optimization problems. Given a complete graph [Formula: see text] and non-negative distances d for every edge, the TSP asks for a shortest tour through all vertices with respect to the distances d. The method of choice for solving the TSP to optimality is a branch and cut approach. Usually the integrality constraints are relaxed first and all separation processes to identify violated inequalities are done on fractional solutions...
2017: Cent Eur J Oper Res
https://www.readbyqxmd.com/read/28684764/heterogeneity-of-odorant-identification-impairment-in-patients-with-alzheimer-s-disease
#15
Yumi Umeda-Kameyama, Shinya Ishii, Masashi Kameyama, Kenji Kondo, Atsushi Ochi, Tatsuya Yamasoba, Sumito Ogawa, Masahiro Akishita
Alzheimer's disease (AD) patients exhibit olfactory dysfunction. However, the olfactory declineti precise nature is not fully understood. One hundred patients (60 AD, 28 amnestic mild cognitive impairment (aMCI), 12 Normal) were enrolled. All participants underwent olfactory function testing using an odour stick identification test for Japanese (OSIT-J). OSIT-J scores were significantly correlated with recall. We classified OSIT-J odorants into three groups: Category I, odorants that were difficult for normal aged subjects to identify; Category II, odorants that became harder to accurately identify with cognitive decline; and Category III, odorants that even AD patients could identify...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28682187/making-vaccine-messaging-stick-perceived-causal-instability-as-a-barrier-to-effective-vaccine-messaging
#16
Graham N Dixon
Health officials often face challenges in communicating the risks associated with not vaccinating, where persuasive messages can fail to elicit desired responses. However, the mechanisms behind these failures have not been fully ascertained. To address this gap, an experiment (N = 163) tested the differences between loss-framed messages-one emphasizing the consequence of not receiving a flu vaccine; the other emphasizing the consequence of receiving the flu vaccine. Despite an identical consequence (i.e., Guillain-Barre syndrome), the message highlighting the consequence of not receiving the flu vaccine produced lower negative affect scores as compared to the message highlighting the consequence of receiving the flu vaccine...
July 6, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28682006/air-trapping-in-early-cystic-fibrosis-lung-disease-does-ct-tell-the-full-story
#17
Tim Rosenow, Kathryn Ramsey, Lidija Turkovic, Conor P Murray, L Clara Mok, Graham L Hall, Stephen M Stick
INTRODUCTION: Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as "air trapping". It is presumed to be localized hyperinflation due to small airway obstruction. In order to test this assumption, we compared air trapping extent to lung volumes measured on CT in young children with CF. MATERIALS AND METHODS: Children aged below 7 years undergoing inspiratory/expiratory CT were recruited from the Australian Respiratory Early Surveillance Team for Cystic Fibrosis cohort...
July 6, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28680663/sticking-to-rough-surfaces-using-functionally-graded-bio-inspired-microfibres
#18
Serdar Gorumlu, Burak Aksak
Synthetic fibrillar adhesives inspired by nature, most commonly by the gecko lizard, have been shown to strongly and repeatedly attach to smooth surfaces. These adhesives, mostly of monolithic construction, perform on par with their natural analogues on smooth surfaces but exhibit far inferior adhesive performance on rough surfaces. In this paper, we report on the adhesive performance of functionally graded microfibrillar adhesives based on a microfibre with a divergent end and a thin soft distal layer on rough surfaces...
June 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28679231/a-bayesian-nonparametric-approach-to-reconstruction-and-prediction-of-random-dynamical-systems
#19
Christos Merkatas, Konstantinos Kaloudis, Spyridon J Hatjispyros
We propose a Bayesian nonparametric mixture model for the reconstruction and prediction from observed time series data, of discretized stochastic dynamical systems, based on Markov Chain Monte Carlo methods. Our results can be used by researchers in physical modeling interested in a fast and accurate estimation of low dimensional stochastic models when the size of the observed time series is small and the noise process (perhaps) is non-Gaussian. The inference procedure is demonstrated specifically in the case of polynomial maps of an arbitrary degree and when a Geometric Stick Breaking mixture process prior over the space of densities, is applied to the additive errors...
June 2017: Chaos
https://www.readbyqxmd.com/read/28670190/newborn-screening-for-thyroid-stimulating-hormone-as-an-indicator-for-assessment-of-iodine-status-in-the-republic-of-macedonia
#20
Violeta Anastasovska, Mirjana Kocova
BACKGROUND: Iodine deficiency is associated with goiter and impaired brain function leading to cretinism. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mlU/L on newborn screening points toward an impaired iodine status of the population. METHODS: A 13-year retrospective analysis was performed in 228,266 newborns participating in the national thyroid newborn screening program. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 48 hours after birth, using fluoroimmunometric DELFIA method...
October 2016: Journal of Medical Biochemistry
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