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JOURNAL ARTICLE
Aditya Kulkarni, Jianli Zhou, Neha Biyani, Umesh Kathad, Partha P Banerjee, Shiv Srivastava, Zsombor Prucsi, Kamil Solarczyk, Kishor Bhatia, Reginald B Ewesuedo, Panna Sharma
Homologous recombination (HR) related gene alterations are present in a significant subset of prostate, breast, ovarian, pancreatic, lung and colon cancers rendering these tumors as potential responders to specific DNA damaging agents. A small molecule acylfulvene prodrug, LP-184, metabolizes to an active compound by the oxidoreductase activity of enzyme Prostaglandin Reductase 1 (PTGR1), which is frequently elevated in multiple solid tumor types. Prior work demonstrated that cancer cell lines deficient in a spectrum of (DNA damage repair) DDR pathway genes show increased susceptibility to LP-184...
April 17, 2024: Cancer Res Commun
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JOURNAL ARTICLE
Alexander M Xu, Marcela Haro, Ann E Walts, Ye Hu, Joshi John, Beth Y Karlan, Akil Merchant, Sandra Orsulic
High-grade serous ovarian carcinoma (HGSOC), the deadliest form of ovarian cancer, is typically diagnosed after it has metastasized and often relapses after standard-of-care platinum-based chemotherapy, likely due to advanced tumor stage, heterogeneity, and immune evasion and tumor-promoting signaling from the tumor microenvironment. To understand how spatial heterogeneity contributes to HGSOC progression and early relapse, we profiled an HGSOC tissue microarray of patient-matched longitudinal samples from 42 patients...
April 19, 2024: Science Advances
#3
REVIEW
Ahmet Cetinkaya, S Irem Kaya, Fatma Budak, Sibel A Ozkan
Ovarian cancer, which affects the female reproductive organs, is one of the most common types of cancer. Since this type of cancer has a high mortality rate from gynaecological cancers, the scientific community shows great interest in studies on its treatment. Chemotherapy, radiotherapy, and surgical treatment methods are used in its treatment. In the absence of targeted treatments in these treatment methods, side effects occur in patients, and patients show resistance to the drug. In addition, the underlying causes of ovarian cancer are still not fully known...
April 17, 2024: Critical Reviews in Analytical Chemistry
#4
JOURNAL ARTICLE
Fabiola Giudici, Angela De Paoli, Federica Toffolutti, Stefano Guzzinati, Silvia Francisci, Lauro Bucchi, Gemma Gatta, Elena Demuru, Sandra Mallone, Antonella Dal Cin, Adele Caldarella, Francesco Cuccaro, Enrica Migliore, Maria Letizia Gambino, Alessandra Ravaioli, Antonella Puppo, Margherita Ferrante, Giuliano Carrozzi, Fabrizio Stracci, Antonino Musolino, Cinzia Gasparotti, Rossella Cavallo, Walter Mazzucco, Maria Francesca Vitale, Giuseppe Cascone, Paola Ballotari, Stefano Ferretti, Lucia Mangone, Roberto Vito Rizzello, Giuseppe Sampietro, Michael Mian, Lorenza Boschetti, Rocco Galasso, Francesca Bella, Daniela Piras, Alessandra Sessa, Pietro Seghini, Anna Clara Fanetti, Pasquala Pinna, Roberta De Angelis, Diego Serraino, Luigino Dal Maso, Airtum Working Group
This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynaecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate Net Survival (NS), Cure Fraction, Time To Cure (5-year conditional NS>95%), Cure Prevalence (women who will not die of cancer), and Already Cured (living longer than Time to Cure). In 2018, 0.4% (121,704) of Italian women were alive after corpus uteri cancer, 0...
April 15, 2024: American Journal of Epidemiology
#5
JOURNAL ARTICLE
Jingkaiwen Zhang, Hanlin Yang, Fang Wen, Qing Li, Hao Luo, Dan Zi
BACKGROUND: Eukaryotic Initiation Factor 3C (EIF3C) represents a pivotal translational initiation factor in eukaryotes and has been shown to facilitate the progression of various neoplasms. However, its mechanistic role in ovarian cancer remains elusive. METHODS: In this research, the expression of EIF3C in ovarian cancer tissues was investigated using immunohistochemistry. In addition, the assessments were made on changes in cellular proliferation, invasion, and apoptotic abilities by reducing the expression of EIF3C in ovarian cancer cells...
April 15, 2024: Recent Patents on Anti-cancer Drug Discovery
#6
REVIEW
Anna Markowska, Zbigniew Kojs, Damian Twardawa, Joanna Pietras, Janina Markowska
Despite advances in surgical treatment techniques and chemotherapy-including anti-angiogenic and immune poly (ADP-ribose) polymerase inhibitors, the 5-year survival rate in ovarian cancer (OC) remains low. The reasons for this are the diagnosis of cancer in advanced clinical stages, chemoresistance and cancer recurrence. New therapeutic approaches are being developed, including the search for new biomarkers that are also targets for targeted therapy. The present review describes new molecular markers with relevance to targeted therapy, which to date have been studied only in experimental research...
May 2024: Experimental and Therapeutic Medicine
#7
JOURNAL ARTICLE
Brittany Dang, Madison Clewis, Brittany Miles, Quan Nguyen
BACKGROUND: Fibrocystic breast changes (FCCs) are benign lesions thought to be caused by an increased estrogen-to-progesterone ratio. One of the most common endocrinopathies that increases this ratio is polycystic ovarian syndrome (PCOS). Although nonproliferative FCCs do not increase the risk of breast cancer, they can make mammographic detection of malignancy in postmenopausal women more difficult. The aim of this study was to investigate the effects of PCOS on the development of postmenopausal FCCs...
2024: Proceedings of the Baylor University Medical Center
#8
JOURNAL ARTICLE
Lubna F Abu-Niaaj, Hala I Al-Daghistani, Ibrahim Katampe, Bashaer Abu-Irmaileh, Yasser K Bustanji
This is a comparative study to evaluate the effectiveness of six pomegranate peel extracts (PPEs) as antibacterial and antiproliferative agents. The Six PPEs were prepared using four solvent systems and each filtrate was concentrated to a gummy material to be used in the evaluation. The well-diffusion method was used to evaluate their antimicrobial activity against bacteria typically associated with food spoilage: Escherichia coli , Pseudomonas aeruginosa , Salmonella typhimurium , Listeria monocytogenes , Staphylococcus epidermidis , Staphylococcus aureus , and three Bacillus species ...
April 2024: Food Science & Nutrition
#9
JOURNAL ARTICLE
Priyanka Gautam, Sameer Gupta, Manisha Sachan
Ovarian cancer, among all gynecologic malignancies, exhibits the highest incidence and mortality rate, primarily because it is often presents with non-specific or no symptoms during its early stages. For the advancement of Ovarian Cancer Diagnosis, it is crucial to identify the potential molecular signatures that could significantly differentiate between healthy and ovarian cancerous tissues and can be used further as a diagnostic biomarker for detecting ovarian cancer. In this study, we investigated the genome-wide methylation patterns in ovarian cancer patients using Methylated DNA Immunoprecipitation (MeDIP-Seq) followed by NGS...
April 16, 2024: Journal of Ovarian Research
#10
JOURNAL ARTICLE
Liang Shen, Aihua Li, Jing Cui, Haixia Liu, Shiqian Zhang
BACKGROUND: To establish a prognostic risk profile for ovarian cancer (OC) patients based on cancer-associated fibroblasts (CAFs) and gain a comprehensive understanding of their role in OC progression, prognosis, and therapeutic efficacy. METHODS: Data on OC single-cell RNA sequencing (scRNA-seq) and total RNA-seq were collected from the GEO and TCGA databases. Seurat R program was used to analyze scRNA-seq data and identify CAFs clusters corresponding to CAFs markers...
April 16, 2024: Journal of Ovarian Research
#11
JOURNAL ARTICLE
T Schlaiss, L Bott, S-L Herbert, C Bartmann, M Kiesel, J Salmen, S T Sauer, S A Christner, B Petritsch, J-P Grunz, A Woeckel, S Löb, J Diessner
PURPOSE: Isolated locoregional recurrence of breast cancer (ILRR) and contralateral breast cancer (CBC) affect up to 20% of all breast cancer (BC) patients in the first 20 years after primary diagnosis. Treatment options comprise surgical interventions and further systemic therapies depending on the histological subtype. Patients with hereditary breast or ovarian cancer (HBOC) undergo MRI, mammography, and ultrasound in the aftercare of BC, while non-HBOC (nHBOC) patients do not regularly receive MRI...
April 17, 2024: Journal of Cancer Research and Clinical Oncology
#12
JOURNAL ARTICLE
Siti Nawwal Ahmad Nasfy, Habibah Abdul Hamid, Azalea Md Khairuddin, Maryam Kameelah Mohamad Fauzi
Gliomatosis peritonei (GP) and Growing Teratoma Syndrome (GTS) are rare and clinically significant conditions often associated with ovarian teratomas. GP involves the development of benign glial implants on the peritoneal surface, while GTS is characterised by the growth of benign, yet enlarging peritoneal implants following chemotherapy for malignant germ cell tumours. These implants are typically histologically mature teratomas devoid of malignancy. Our report documents a unique case where both GP and GTS manifested in a patient undergoing treatment for an immature ovarian teratoma...
April 16, 2024: BMJ Case Reports
#13
JOURNAL ARTICLE
Timo Westermann, Edin Karabeg, Florian Heitz, Alexander Traut, Helmut Plett, Malak Moubarak, Julia Welz, Sebastian Heikaus, Sigurd Lax, Andreas du Bois, Philipp Harter
OBJECTIVE: Borderline tumors of the ovary are a rare group of ovarian neoplasms with distinctive histological features. Considering their favorable prognosis and occurrence at a younger age, fertility-sparing surgery may be considered. Several risk factors have been identified as contributing to a higher recurrence rate, while the impact of pathohistological features varies in the literature. This study aimed to analyze risk factors for recurrence in patients with borderline tumors of the ovary...
April 16, 2024: International Journal of Gynecological Cancer
#14
JOURNAL ARTICLE
Ghanim Khatib, Emine Gulen Kucukbingoz, İrem Hatipoglu, Mehmet Ali Vardar
No abstract text is available yet for this article.
April 16, 2024: International Journal of Gynecological Cancer
#15
JOURNAL ARTICLE
Xuezhong Shi, Anqi Bu, Yongli Yang, Yuping Wang, Chenyu Zhao, Jingwen Fan, Chaojun Yang, Xiaocan Jia
High heritability and strong correlation have been observed in breast and ovarian cancers. However, their shared genetic architecture remained unclear. Linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (ρ-HESS) were applied to estimate heritability and genetic correlations. Bivariate causal mixture model (MiXeR) was used to qualify the polygenic overlap. Then, stratified-LDSC (S-LDSC) was used to identify tissue and cell type specificity. Meanwhile, the adaptive association test called MTaSPUsSet was performed to identify potential pleiotropic genes...
2024: Genetics and Molecular Biology
#16
JOURNAL ARTICLE
Sha Ni, Jiaqi He, Ling Ouyang
OBJECTIVES: Limited data are available on patients with advanced-stage epithelial ovarian cancer (OC) who require ostomy during primary cytoreductive surgery. This study aimed to investigate the application of postoperative and long-term oncological results from transitory protective stoma (TPS) formation during primary debulking surgery (PDS) for OC. METHODS: This is a retrospective cohort study with a single center. We identified patients with stage III-IV OC who underwent colon resection and anastomosis...
April 16, 2024: International Journal of Surgery
#17
JOURNAL ARTICLE
Sun Chenchen, Qian Xueqian, Lu Yahui, Yuan Yi, Zhang Hui, Bai Lanning, Cheng Min, Han Yangyang
The treatment of ovarian cancer remains a medical challenge and its malignant progression is connected with obvious changes in both tissue and cell stiffness. However, the accurate mechanical-responsive molecules and mechanism remains unclear in ovarian cancer. Based on our previous results combined with the crucial regulatory role of STAT3 in the malignant progression of various cancer types, we want to investigate the relationship between STAT3 and matrix stiffness in ovarian cancer and further explore the potential mechanisms...
April 16, 2024: Molecular and Cellular Biochemistry
#18
JOURNAL ARTICLE
Summer C Martin, Allison M Scott, Anne M Stone
Inheriting a pathogenic variant in the BRCA1 or BRCA2 gene considerably increases a woman's risk levels for developing breast and ovarian cancer. In addition to serious physical health implications, women with a BRCA pathogenic variant may face psychosocial challenges, including those related to navigating the often demanding process of communicating about topics regarding BRCA with family and other social network members. Based on in-depth interviews with 24 women who tested BRCA-positive, we found that-consistent with the conceptualization of communication work articulated by Donovan-Kicken et al...
April 16, 2024: Journal of Genetic Counseling
#19
JOURNAL ARTICLE
Jin Ju Kim, Dong Ja Kim, Eon Jeong Nam, Kyung Eun Song, Ji Yeon Ham, Yu Kyung Kim, Nan Young Lee
BACKGROUND: Hereditary breast/ovarian cancer is associated with BRCA gene mutations. As large volumes of clinical data on BRCA variants are continuously updated, their clinical interpretation may change, leading to their reclassification. This study analyzed the class and proportion of the changed clinical interpretations of BRCA variants to validate the need for periodic reviews of these variants. METHODS: This retrospective study reinterpreted previously reported BRCA1 and BRCA2 exon variants according to the 2015 American College of Medical Genetics and Genomics guidelines and the clinical significance of the recent public genomic database...
April 1, 2024: Clinical Laboratory
#20
JOURNAL ARTICLE
Lingling Xie, Shaodan Lin, Haibo Zhao, Zhongqiu Lin, Huaiwu Lu
INTRODUCTION: Epithelial Ovarian cancer most commonly presents at advanced stages with extra-abdominal disease metastasis. Notably, enlarged cardiophrenic lymph nodes are found in 10.5-62 % of patients with advanced ovarian cancer. However, the safety and feasibility of cardiophrenic lymph nodes dissection as a component of debulking surgery remains controversial (Acs et al., 2022, Agusti et al., 2024). CASE/METHODS: We present a surgical video demonstrating the technique of bulky pericardial mass and metastatic cardiophrenic lymph nodes resection by transdiaphragmatic approach in advanced ovarian cancer...
June 2024: Gynecologic Oncology Reports
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