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Diet and cancer

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https://www.readbyqxmd.com/read/29148069/long-term-oral-exposure-to-safe-dose-of-bisphenol-a-in-association-with-high-fat-diet-stimulate-the-prostatic-lesions-in-a-rodent-model-for-prostate-cancer
#1
Camila H Facina, Silvana G P Campos, Bianca F Gonçalves, Rejane M Góes, Patricia S L Vilamaior, Sebastião R Taboga
BACKGROUND: Studies have shown that exposure to environmental chemicals known as endocrine disruptors can cause permanent changes in genital organs, such as the prostate. Among these environmental chemicals stands out bisphenol A (BPA). Another factor associated with prostate changes is the consumption of a high-fat diet. Although the relationship between the consumption of a high-fat diet and an increased risk of prostate cancer is well established, the mechanisms that lead to the establishment of this disease are not completely understood, nor the simultaneous action of BPA and high-fat diet...
November 17, 2017: Prostate
https://www.readbyqxmd.com/read/29146179/soft-palate-reconstruction-after-radionecrosis-combined-anterolateral-thigh-adipofascial-and-nasoseptal-flaps
#2
Joseph Zenga, Jeffrey D Sharon, Jennifer Gross, Jay Gantz, Patrik Pipkorn
Although radiation-based treatment for nasopharyngeal cancer may achieve excellent long term oncologic results, late effects of therapy may lead to soft tissue radionecrosis and velopharyngeal insufficiency (VPI). Repair of these oro- and nasopharyngeal defects presents a complex reconstructive challenge. We present a case of a long-term survivor treated with chemoradiotherapy for nasopharyngeal cancer who developed progressive dysphagia, velopharyngeal insufficiency, and radionecrosis of the nasopharynx and soft palate, leading to tracheostomy and gastrostomy tube dependence...
November 13, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29145355/disparities-in-state-specific-adult-fruit-and-vegetable-consumption-united-states-2015
#3
Seung Hee Lee-Kwan, Latetia V Moore, Heidi M Blanck, Diane M Harris, Deb Galuska
The 2015-2020 Dietary Guidelines for Americans recommend that Americans consume more fruits and vegetables as part of an overall dietary pattern to reduce the risk for diet-related chronic diseases such as cardiovascular disease, type 2 diabetes, some cancers, and obesity (1). Adults should consume 1.5-2.0 cup equivalents of fruits and 2.0-3.0 cups of vegetables per day.* Overall, few adults in each state met intake recommendations according to 2013 Behavioral Risk Factor Surveillance System (BRFSS) data; however, sociodemographic characteristics known to be associated with fruit and vegetable consumption were not examined (2)...
November 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29144984/developing-a-scale-to-assess-health-regulatory-focus
#4
Rebecca A Ferrer, Isaac M Lipkus, Jennifer L Cerully, Colleen M McBride, James A Shepperd, William M P Klein
RATIONALE: Regulatory focus (i.e., focus on motivation to achieve gains or avoid losses and non-gains) is used to tailor health behavior change interventions, improving efficacy, but is currently assessed by scales that are not health-specific and may capture a version of the construct that is not ideally matched to the rationale for tailoring. OBJECTIVE: We developed and validated a Health Regulatory Focus Scale (HRFS), which assesses tendencies to avoid negative health consequences (prevention focus) or achieve positive health outcomes (promotion focus)...
November 13, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29143974/%C3%AE-h2ax-formation-in-the-urinary-bladder-of-rats-treated-with-two-norharman-derivatives-obtained-from-o-toluidine-and-aniline
#5
T Toyoda, Y Totsuka, K Matsushita, T Morikawa, N Miyoshi, K Wakabayashi, K Ogawa
Aminomethylphenylnorharman (AMPNH) and aminophenylnorharman (APNH) are mutagenic norharman derivatives obtained from o-toluidine and aniline, respectively. APNH is carcinogenic to the urinary bladder of rats and present in urine samples of healthy volunteers, indicating that norharman derivatives may be associated with cancer development in the urinary bladder of humans. To evaluate the possible role of AMPNH and APNH in bladder carcinogenesis, we examined the formation of γ-H2AX, a DNA damage response marker, in the urinary bladder of rats...
November 16, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29143540/association-between-nutrition-resource-stress-and-dietary-consumption-results-from-a-u-s-nationally-representative-survey
#6
Emily Grenen, Erin E Kent, Erin Hennessy, Jada G Hamilton, Rebecca A Ferrer
BACKGROUND: There is little research on how affective reactions (e.g., stress) to perceptions of nutritious food accessibility contribute to dietary behaviors. AIMS: This study explores whether stress associated with limited access to nutritious foods-termed nutrition resource stress (NRS)-contributes to diet outcomes, and whether these associations are mediated by health-related self-efficacy. METHOD: Using data from the cross-sectional National Cancer Institute's Health Information National Trends Survey, analyses were conducted to examine whether reported NRS was associated with specific dietary behaviors (i...
November 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29142587/factors-associated-with-the-high-prevalence-of-oesophageal-cancer-in-western-kenya-a-review
#7
REVIEW
Gabriel Kigen, Naftali Busakhala, Zipporah Kamuren, Hillary Rono, Wilfred Kimalat, Evangeline Njiru
Oesophageal carcinoma (OC) is highly prevalent in Western Kenya especially among the members of the Kalenjin community who reside in the Northern and Southern areas of the Rift Valley. Previous authors have suggested potential association of environmental and genetic risk factors with this high prevalence. The environmental factors that have been suggested include contamination of food by mycotoxins and/or pesticides, consumption of traditional alcohol (locally referred to "Busaa" and "Chan'gaa"), use of fermented milk ("Mursik"), poor diet, tobacco use and genetic predisposition...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29141575/the-protective-effects-of-extra-virgin-olive-oil-on-immune-mediated-inflammatory-responses
#8
Rosa Casas, Ramon Estruch, Emilio Sacanella
BACKGROUND AND OBJECTIVE: The increasing interest in the Mediterranean diet (MeDiet) hinges on the relevant role it plays in inflammatory diseases. Several clinical, epidemiological and experimental evidences suggest that consumption of the MeDiet reduces the incidence of certain pathologies related to oxidative stress, chronic inflammation and immune system diseases such as cancer, atherosclerosis and cardiovascular disease (CVD). DISCUSSION: These reductions can be partially attributed to extra virgin olive oil (EVOO) consumption which has been described as a key bioactive food because of its high nutritional quality and its particular composition of fatty acids, vitamins and polyphenols...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29141574/anti-inflammatory-activity-of-extra-virgin-olive-oil-polyphenols-which-role-in-the-prevention-and-treatment-of-immune-mediated-inflammatory-diseases
#9
Carmela Santangelo, Rosaria Vari, Beatrice Scazzocchio, Patrizia De Sanctis, Claudio Giovannini, Massimo D'Archivio, Roberta Masella
Altered inflammatory response characterizes chronic immune-mediated inflammatory diseases (IMID) such as rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, and psoriasis. Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source of fat in the Mediterranean diet, is associated with a reduced risk of developing chronic degenerative disorders such cardiovascular diseases, type 2 diabetes and cancer. The beneficial effects on health of EVOO have been attributed, besides to the monounsaturated fats content, to the presence of phenolic compounds that have antioxidant, anti-inflammatory and immunomodulatory properties...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29140985/notch-signaling-and-progenitor-ductular-reaction-in-steatohepatitis
#10
Carola M Morell, Romina Fiorotto, Marica Meroni, Aileen Raizner, Barbara Torsello, Massimiliano Cadamuro, Gaia Spagnuolo, Eleanna Kaffe, Salvatore Sutti, Emanuele Albano, Mario Strazzabosco
BACKGROUND AND OBJECTIVE: Persistent hepatic progenitor cells (HPC) activation resulting in ductular reaction (DR) is responsible for pathologic liver repair in cholangiopathies. Also, HPC/DR expansion correlates with fibrosis in several chronic liver diseases, including steatohepatitis. Increasing evidence indicates Notch signaling as a key regulator of HPC/DR response in biliary and more in general liver injuries. Therefore, we aimed to investigate the role of Notch during HPC/DR activation in a mouse model of steatohepatitis...
2017: PloS One
https://www.readbyqxmd.com/read/29140733/proinflammatory-dietary-intake-is-associated-with-increased-risk-of-colorectal-cancer-results-of-a-case-control-study-in-argentina-using-a-multilevel-modeling-approach
#11
Camila Niclis, Sonia A Pou, Nitin Shivappa, James R Hébert, Susan E Steck, María Del Pilar Díaz
Little evidence regarding the inflammatory potential of diet and its effect on colorectal cancer exists in Latin American countries. The aim of the present study was to evaluate the association between the Dietary Inflammatory Index (DII®) and colorectal cancer (CRC) risk in Córdoba, Argentina. A frequency-matched case-control study (N = 446, including 144 (32.3%) CRC cases and 302 (67.7%) controls was conducted in Córdoba (Argentina) from 2008 through 2015. DII® scores were computed based on dietary intake assessed by a validated food frequency questionnaire (FFQ)...
November 15, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29140419/dietary-glutamine-glutamate-and-mortality-two-large-prospective-studies-in-us-men-and-women
#12
Wenjie Ma, Yoriko Heianza, Tao Huang, Tiange Wang, Dianjianyi Sun, Yan Zheng, Frank B Hu, Kathryn M Rexrode, JoAnn E Manson, Lu Qi
Background: Emerging studies have related circulating glutamine metabolites to various chronic diseases such as cardiovascular disease and cancer; diet is the major source of nutrients involved in glutamine metabolism. However, it remains unknown whether dietary intakes of glutamine, glutamate,and their ratio are related to total and cause-specific mortality. Methods: We followed 74 082 women from the Nurses' Health Study (1984-2012) and 42 303 men from the Health Professionals Follow-up Study (1986-2012), who were free of cardiovascular disease and cancer at baseline...
November 13, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29139074/excessive-use-of-nitrogenous-fertilizers-an-unawareness-causing-serious-threats-to-environment-and-human-health
#13
Moddassir Ahmed, Muhammad Rauf, Zahid Mukhtar, Nasir Ahmad Saeed
Farmers occasionally need to add nitrogen fertilizer to their farms and gardens to make available just the precise nutrients for their plants' growth. The applications of inorganic nitrogen fertilizers to various crops have been continuously increasing since last many decades globally. Although nitrogen fertilizer contributes substantially to yield enhancement, but excessive use of this manure has posed serious threats to environment and human health. Rate of nitrogen fertilizers application has a close relationship with nitrate accumulation in surrounding environment, groundwater, as well as leafy and root vegetables...
November 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29138133/effects-of-weight-loss-interventions-for-adults-who-are-obese-on-mortality-cardiovascular-disease-and-cancer-systematic-review-and-meta-analysis
#14
Chenhan Ma, Alison Avenell, Mark Bolland, Jemma Hudson, Fiona Stewart, Clare Robertson, Pawana Sharma, Cynthia Fraser, Graeme MacLennan
Objective To assess whether weight loss interventions for adults with obesity affect all cause, cardiovascular, and cancer mortality, cardiovascular disease, cancer, and body weight.Design Systematic review and meta-analysis of randomised controlled trials (RCTs) using random effects, estimating risk ratios, and mean differences. Heterogeneity investigated using Cochran's Q and I(2) statistics. Quality of evidence assessed by GRADE criteria.Data sources Medline, Embase, the Cochrane Central Register of Controlled Trials, and full texts in our trials' registry for data not evident in databases...
November 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29138005/distinct-hypoxic-regulation-of-preadipocyte-factor-1-pref-1-in-preadipocytes-and-mature-adipocytes
#15
Yunwon Moon, Seongyeol Lee, Bongju Park, Hyunsung Park
Preadipocyte factor-1 (Pref-1) is a secretory soluble protein, which exerts pleiotropic effects on maintenance of cancer stem cell characteristics and commitment of mesenchymal stem cell lineages by inhibiting adipogenesis. Observations that obesity renders the microenvironment of adipose tissues hypoxic and that hypoxia inhibits adipogenesis lead us to investigate whether hypoxia increases the expression of anti-adipogenic Pref-1 in preadipocytes, mature adipocytes, and adipose tissues from obese mouse. In 3T3-L1 preadipocytes, hypoxia induces Pref-1 by a hypoxia-inducible factor 1 (HIF-1)-dependent mechanism accompanied by increase in the levels of the active histone mark, acetylated H3K9/14 (H3K9/14Ac)...
November 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29137948/analysis-of-tumor-biology-to-advance-cancer-health-disparity-research
#16
REVIEW
Cheryl Jacobs Smith, Tsion Zewdu Minas, Stefan Ambs
Cancer mortality rates in the US continue to decline. Reductions in tobacco use, uptake of preventive measures, adoption of early detection methods, and better treatments have resulted in improved cancer outcomes for men and women. Despite this progress, some population groups continue to experience an excessive cancer burden when compared with other population groups. One of the most prominent cancer health disparities exists in prostate cancer. Prostate cancer mortality rates are highest among men of African ancestry when compared with other men, both in the US and globally...
November 11, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29137335/inhibition-of-cell-cycle-progression-by-the-hydroxytyrosol-cetuximab-combination-yields-enhanced-chemotherapeutic-efficacy-in-colon-cancer-cells
#17
Erika Terzuoli, Ginevra Nannelli, Maria Frosini, Antonio Giachetti, Marina Ziche, Sandra Donnini
Hydroxytyrosol (HT), a polyphenol of olive oil, downregulates epidermal growth factor (EGFR) expression and inhibits cell proliferation in colon cancer (CC) cells, with mechanisms similar to that activated by the EGFR inhibitor, cetuximab. Here, we studied whether HT treatment would enhance the cetuximab inhibitory effects on cell growth in CC cells. HT-cetuximab combination showed greater efficacy in reducing cell growth in HT-29 and WiDr cells at concentrations 10 times lower than when used as single agents...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135979/a-systematic-review-of-grandparents-influence-on-grandchildren-s-cancer-risk-factors
#18
Stephanie A Chambers, Neneh Rowa-Dewar, Andrew Radley, Fiona Dobbie
Many lifestyle patterns are established when children are young. Research has focused on the potential role of parents as a risk factor for non communicable disease in children, but there is limited investigation of the role of other caregivers, such as grandparents. The aim of this review was to identify and synthesise evidence for any influence grandparents' care practices may have on their grandchildren's long term cancer risk factors. A systematic review was carried out with searches across four databases (MEDLINE, Embase, Web of Science, PsycINFO) as well as searches of reference lists and citing articles, and Google Scholar...
2017: PloS One
https://www.readbyqxmd.com/read/29134650/thyroid-associated-genetic-polymorphisms-in-relation-to-breast-cancer-risk-in-the-malm%C3%A3-diet-and-cancer-study
#19
Jasmine Brandt, Signe Borgquist, Peter Almgren, Asta Försti, Linnea Huss, Olle Melander, Jonas Manjer
Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet and Cancer Study (a population-based prospective study consisting of 17,035 women) to examine 17 single nucleotide polymorphisms (SNPs) previously related to levels of free thyroxine (free T4) and thyroid peroxidase antibodies (TPO-Ab) as potential genetic risk factors for breast cancer...
November 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29134640/reduced-il-6-levels-and-tumor-associated-phospho-stat3-are-associated-with-reduced-tumor-development-in-a-mouse-model-of-lung-cancer-chemoprevention-with-myo-inositol
#20
Nese Unver, Oliver Delgado, Kirubel Zeleke, Amber Cumpian, Ximing Tang, Mauricio S Caetano, Hong Wang, Hiroyuki Katayama, Hua Yu, Eva Szabo, Ignacio Wistuba, Seyed Javad Moghaddam, Samir Hanash, Edwin J Ostrin
Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras expressed in the airway epithelium (Ccsp(Cre/+) ; Kras(LSL-G12D/+) ) were raised on diets compounded with myo-inositol. These animals form lung premalignant lesions in a stereotypical fashion over the ten weeks following weaning...
November 14, 2017: International Journal of Cancer. Journal International du Cancer
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