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https://www.readbyqxmd.com/read/28422560/effect-of-physical-activity-intervention-in-prediabetes-a-systematic-review-with-meta-analysis
#1
Radhika Aditya Jadhav, Animesh Hazari, Ashma Monterio, Sampath Kuman, Arun G Maiya
BACKGROUND: Prediabetes is a strong risk factor for the development of Type2 Diabetes Mellitus (T2DM). Modification in lifestyle plays an important role to avoid the prognosis of T2DM and its complications in future. The aim of our study was to focus on the effectiveness of physical activity (PA) intervention program on different outcome measures in individuals with prediabetes. The effort of the present review was to contribute to the existing literature by strengthening the evidence pointing towards the positive impact of physical activity in individuals with prediabetes...
April 19, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28393626/in-silico-modelling-and-molecular-dynamics-simulation-studies-of-thiazolidine-based-ptp1b-inhibitors
#2
Manoj Kumar Mahapatra, Krishnendu Bera, Durg Vijay Singh, Rajnish Kumar, Manoj Kumar
Protein tyrosine phosphatase 1B (PTP1B) has been identified as negative regulator of insulin and leptin signalling pathway, hence it can be considered as a new therapeutic target of intervention for the treatment of type2 diabetes. Inhibition of this molecular target takes care of both diabetes and obesity, i.e., diabestiy. In order to get more information on identification and optimisation of lead, pharmacophore modelling, atom-based 3D QSAR, docking and molecular dynamics studies were carried out on a set of ligands containing thiazolidine scaffold...
April 10, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28392356/serum-chitotriosidase-enzyme-activity-is-closely-related-to-hba1c-levels-and-the-complications-in-patients-with-diabetes-mellitus-type-2
#3
Emre Turan, Bulent Sozmen, Mine Eltutan, Eser Y Sozmen
AIMS: Chitotriosidase, is a macrophage sourced enzyme which shows high activity during the course of various storage disorders such as Gaucher's Disease. The aforementioned macrophage sourced enzyme, which has a role in basic immune response, is also high in patients with diabetes. This study was designed to determine the chitotriosidase activities in patients with diabetes and the relationship between the complication of diabetes and chitotriosidase activity. MATERIALS METHODS: This study included 76 patients with type2 diabetes mellitus and 76 healthy subjects...
March 31, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28348972/antidiabetic-hypolipidemic-and-hepatoprotective-effects-of-arctium-lappa-root-s-hydro-alcoholic-extract-on-nicotinamide-streptozotocin-induced-type-2-model-of-diabetes-in-male-mice
#4
Akram Ahangarpour, Hamid Heidari, Ali Akbar Oroojan, Farhang Mirzavandi, Khalil Nasr Esfehani, Zeinab Dehghan Mohammadi
OBJECTIVE: Arctium lappa (burdock), (A. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties of A. lappa root extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice. MATERIALS AND METHODS: In this investigation, 70 adult male NMRI mice (30-35g) randomly divided into 7 groups (n=10) as follow: 1-control, 2-type 2 diabetic mice, 3-diabetic mice that received glibenclamide (0...
March 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28289653/efficacy-of-low-and-moderate-intensity-statins-for-achieving-low-density-lipoprotein-cholesterol-targets-in-thai-type-2-diabetic-patients
#5
Nuntakorn Thongtang, Chaiyut Sitthananun, Sutin Sriussadaporn, Wannee Nitiyanant
BACKGROUND: Low dose statins are commonly used among Asians, because plasma low-density lipoprotein cholesterol (LDL-C) reductions similar to those observed in Westerners are achieved at lower doses. We aimed to assess the efficacy of low- and moderate-intensity statins for achieving plasma lipid targets in Thai type2 diabetes (T2D) and to evaluate factors associated with greater LDL-C reduction by statins. METHODS: T2D patients who were treated with low- and moderate-intensity statins at the Siriraj Diabetes Clinic during the January 2013 to December 2014 study period were eligible for inclusion(n = 978), 400 patients were randomly recruited...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28126289/synthesis-biological-evaluation-and-in-silico-studies-of-5-3-methoxybenzylidene-thiazolidine-2-4-dione-analogues-as-ptp1b-inhibitors
#6
Manoj Kumar Mahapatra, Rajnish Kumar, Manoj Kumar
PTP1B (protein tyrosine phosphatase 1B) dephosphorylates the insulin receptor substrate and thus acts as a negative regulator of the insulin and leptin signalling pathway. Recently, it has been considered as a new therapeutic target of intervention for the treatment of type2 diabetes. A series of aryl/alkylsulfonyloxy-5-(3-methoxybenzylidene)thiazolidine-2,4-dione derivatives were synthesized, screened in vitro for their PTP1B inhibitory activity and in vivo for anti-hyperglycaemic activity. Docking results further helped in understanding the nature of interactions governing the binding mode of ligands inside the active site of PTP1B...
January 17, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28072841/a-small-insulinomimetic-molecule-also-improves-insulin-sensitivity-in-diabetic-mice
#7
Sandip Mukherjee, Mrittika Chattopadhyay, Sushmita Bhattacharya, Suman Dasgupta, Sahid Hussain, Saitanya K Bharadwaj, Dhrubajyoti Talukdar, Abul Usmani, Bhola S Pradhan, Subeer S Majumdar, Pronobesh Chattopadhyay, Satinath Mukhopadhyay, Tushar K Maity, Mihir K Chaudhuri, Samir Bhattacharya
Dramatic increase of diabetes over the globe is in tandem with the increase in insulin requirement. This is because destruction and dysfunction of pancreatic β-cells are of common occurrence in both Type1 diabetes and Type2 diabetes, and insulin injection becomes a compulsion. Because of several problems associated with insulin injection, orally active insulin mimetic compounds would be ideal substitute. Here we report a small molecule, a peroxyvanadate compound i.e. DmpzH[VO(O2)2(dmpz)], henceforth referred as dmp, which specifically binds to insulin receptor with considerable affinity (KD-1...
2017: PloS One
https://www.readbyqxmd.com/read/27996163/study-of-il4-590c-t-and-il6-174g-c-gene-polymorphisms-in-type-2-diabetic-patients-with-chronic-kidney-disease-in-north-indian-population
#8
Km Neelofar, Jamal Ahmad, Arif Ahmad, Khursheed Alam
To explore the associations between potential functional promoter polymorphisms in pro-inflammatory and anti-inflammatory (IL-4(-590C/T) and IL-6(-174G/C) cytokine genes, and kidney dysfunction in North Indian type 2 diabetic subjects with chronic kidney disease. A total of 150 subjects aged 25-75 year were included in this study. The glomerular filtration rate (GFR) and serum creatinine were estimated. PCR was performed to analyse genotype distribution in IL-4 (-590T/C) and IL-6 (-174G/C) among healthy, type 2 diabetic patients with or without CKD...
December 20, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27973205/review-of-economic-evaluation-of-saxagliptin-in-type2-diabetes-in-china
#9
C Zhang, C Hu, L Xu
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27921359/modulation-of-vegf-signaling-in-a-mouse-model-of-diabetes-by-xanthohumol-and-8-prenylnaringenin-unveiling-the-angiogenic-paradox-and-metabolism-interplay
#10
Raquel Costa, Ilda Rodrigues, Luísa Guardão, Joana Quelhas Lima, Emília Sousa, Raquel Soares, Rita Negrão
SCOPE: Imbalance in kidney and heart neovascularization is common in type2 diabetes (T2DM) patients. Nevertheless, the mechanisms governing this angiogenic paradox have not been elucidated. Xanthohumol (XN) and 8-prenylnaringenin (8PN) beer polyphenols modulate angiogenesis, being thus targets for T2DM-related complications. Our work examined whether polyphenols consumption affects angiogenic paradox and metabolism in a T2DM mouse model. METHODS AND RESULTS: An increase in kidney and a reduction in left ventricle (LV) microvessels of diabetic C57Bl/6 mice were observed...
December 6, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27903028/-cardiovascular-morbidity-and-mortality-in-patients-with-kidney-disease
#11
REVIEW
Ivo Quack, Ralf Westenfeld
Patients with kidney disease have a significantly increased cardiovascular morbidity and mortality. Especially diabetics have an increased risk to develop renal insufficiency and cardiovascular events. Two recent studies show that the SGLT2 inhibitor Empagliflozin and the GLP1 agonist Liraglutid are able to lower the cardiovascular risk of type2 diabetics with renal insufficiency. Recent observations suggest that bradycardia and asystole are main triggers for sudden cardiac death in patients with chronic kidney disease...
November 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27728185/study-of-clinical-and-biochemical-profile-of-lean-type2-diabetes-mellitus-patients-in-comparison-to-obese-and-non-obese-type-2-diabetes-mellitus-patients
#12
Piyush Mishra, Aarati Lalchandani, J S Kushwaha, Rakesh Chandra, Sakshi Jain
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728135/analysis-of-risk-factors-for-triple-vessel-disease-in-type2-diabetics-needing-cabg
#13
Sarvepalli Partha Saradhi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728133/correlation-of-pulmonary-function-tests-and-duration-of-type2-diabetes-mellitus
#14
Gurram Sreeram
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727618/a-study-of-peripheral-arterial-disease-in-type2-diabetes-mellitus
#15
Oberoi M, Chandrasekhar Ap, Lakhshmi A, Chowdhary As, Singh R
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27705748/cornus-mas-l-cornelian-cherry-an-important-european-and-asian-traditional-food-and-medicine-ethnomedicine-phytochemistry-and-pharmacology-for-its-commercial-utilization-in-drug-industry
#16
REVIEW
Biswanath Dinda, Anthony M Kyriakopoulos, Subhajit Dinda, Vassilis Zoumpourlis, Nikolaos S Thomaidis, Aristea Velegraki, Charlambos Markopoulos, Manikarna Dinda
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus mas L. (cornelian cherry) fruits have been used for centuries as traditional cuisine and folk medicine in various countries of Europe and Asia. In folk medicines, the fruits and other parts of the plant have been used for prevention and treatment of a wide range of diseases such as diabetes, diarrhea, gastrointestinal disorders, fevers, rheumatic pain, skin and urinary tract infections, kidney and liver diseases, sunstroke, among others. This review provides a systematic and constructive overview of ethnomedicinal uses, chemical constituents and pharmacological activities of this plant as well as future research need for its commercial utilization as nutraceutical food supplement and medicine...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27667144/-lixisenatide-in-patients-with-type-2-diabetes-and-obesity-beyond-glycaemic-control
#17
M Mar Roca-Rodríguez, María Teresa Muros de Fuentes, Gonzalo Piédrola-Maroto, Miguel Quesada-Charneco, Silvia Maraver-Selfa, Francisco J Tinahones, Isabel Mancha-Doblas
AIM: To evaluate tolerance to lixisenatide and its effects on weight and metabolic control in type2 diabetes and obese patients. DESIGN: Prospective study. SETTING: Endocrinology clinics in Almeria, Granada and Malaga. PARTICIPANTS: Patients with type2 diabetes and obesity. INTERVENTIONS: Response and tolerance to lixisenatide treatment. MAIN MEASUREMENTS: Clinical and analytical data of the subjects were evaluated at baseline and after treatment...
September 22, 2016: Atencion Primaria
https://www.readbyqxmd.com/read/27613695/is-beta-cell-aging-involved-in-the-pathogenesis-of-diabetes
#18
Junping Wen, Ting Xue, Ying Huang, Xiaoyan Chen, Ying Xue, Wei Lin, Lizhen Zhang, Jin Yao, Huibin Huang, Jixing Liang, Liantao Li, Lixiang Lin, Lidan Shi, Liangchun Cai, Zhuangli Zhu, Gang Chen
BACKGROUND: Beta-cells in different stages have different function and capacity of proliferation, regenerative and apoptosis. We conducted this study to investigate whether there are changes in beta-cell phonotype in the development of diabetes to identify potential beta cell targets for preventing the progression of diabetes. METHODS: We conducted a cross-sectional study of pancreatic tissues obtained from 80 patients classified into three groups: 25 type2 diabetes, 25 impaired fasting glucose, and 30 non-diabetes...
September 10, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27567214/-baseline-characteristics-and-clinical-management-of-the-first-3-000-patients-enrolled-in-the-iberican-study-identification-of-the-spanish-population-at-cardiovascular-and-renal-risk
#19
Sergio Cinza Sanjurjo, Miguel Ángel Prieto Díaz, José Luis Llisterri Caro, Vicente Pallarés Carratalá, Alfonso Barquilla García, Luis Rodríguez Padial, Ángel Díaz Rodríguez, José Polo García, Jesús Vergara Martín, Rafael Vidal Pérez, Gustavo Cristóbal Rodríguez Roca
OBJECTIVES: To determine the prevalence and incidence of cardiovascular risk factors in Spain, as well as cardiovascular events, in Spanish adult population attended in primary care. METHODOLOGY: IBERICAN is a longitudinal, observational, multicenter study in which patients aged 18 to 85years attended in primary care health center in Spain are being included. The obtained cohort will be followed annually for at least 5years. The estimated final sample is 7,000 patients...
August 23, 2016: Semergen
https://www.readbyqxmd.com/read/27508600/-op-1d-02-orthostatic-hypertension-in-normotensive-patients-predicts-permanent-arterial-hypertension-in-type-2-diabetes-mellitus
#20
N Nibouche, N Lanasri, A Chibane, F Zeraoulia, A Bachir-Cherif, A Dahak, L Makhlouf, A Medjahed, A Biad
OBJECTIVE: we aim to study clinical characteristics of normotensive, newly diagnosed type 2 diabetics whom present OHT and to determine the evolution of BP after one year of follow-up. DESIGN AND METHOD: it's a prospective, observational, monocentric, cohort study. The prevalence of OHT was investigated in 327 patients, 122 men and 205 women aged from 40 to 70 years with newly diagnosed type2 diabetes. Arterial hypertension was defined and classified according to OMS and JNC7 recommendations...
September 2016: Journal of Hypertension
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