keyword
https://read.qxmd.com/read/37924771/dose-response-association-of-benzodiazepine-use-and-development-of-deep-vein-thrombosis
#1
JOURNAL ARTICLE
Nai-Chen Shih, Liang-Tsai Yeh, Bo-Yuan Wang, Yu-Hsun Wang, Shun-Fa Yang, Chao-Bin Yeh
Benzodiazepines have sedative effects that cause reduced activity in users and may increase the risk of deep vein thrombosis. However, few studies have examined this potential risk of benzodiazepine use. This study examined the association between benzodiazepine use and the risk of deep vein thrombosis (DVT) in adults in Taiwan using a longitudinal health insurance database. The study population included 12,546 individuals with DVT and 50,184 matched controls. Results showed that benzodiazepine use was associated with an increased risk of DVT occurrence (adjusted odds ratio [aOR]: 1...
October 24, 2023: Psychiatry Research
https://read.qxmd.com/read/37882457/reducing-the-use-of-psychotropics-in-a-convalescent-rehabilitation-ward
#2
JOURNAL ARTICLE
Takuya Uematsu, Takashi Tomita, Ryo Obara, Takuya Gonai, Koshi Hattori, Takanori Aonuma, Kensuke Usui, Hiroaki Tanifuji, Fumiaki Ishizawa, Hiroshi Ishii, Eiji Suzuki
AIMS: Many patients who are transferred to the convalescent rehabilitation ward of Kawasaki Kokoro Hospital (hereinafter, our hospital) are on psychotropics prescribed for delirium by their physicians at acute care hospitals. In this study, psychiatrists and pharmacists collaborated with rehabilitation physicians to reduce the use of psychotropics. METHODS: The basic information and psychotropics prescription statuses of 88 patients discharged from the convalescent rehabilitation ward of our hospital between April 1, 2021 and March 31, 2022 were derived from their medical records...
October 26, 2023: Neuropsychopharmacology Reports
https://read.qxmd.com/read/37695395/secular-trends-in-central-nervous-system-active-polypharmacy-among-serial-cross-sections-of-us-adults-2009-2020
#3
JOURNAL ARTICLE
Samuel W Terman, Joshua D Niznik, Matthew E Growdon, Lauren B Gerlach, James F Burke
BACKGROUND: Data comprehensively examining trends in central nervous system (CNS)-active polypharmacy are limited. The objective of this cross-sectional study was to characterize the composition of and trends in CNS-active medication use in US adults. METHODS: We included all participants ≥ 18 years old in the National Health and Nutrition Examination Study (NHANES), 2009-2020. The primary outcome was the percent of adults with CNS-active polypharmacy. This was defined as ≥ 3 medications among antidepressants [tricyclic, selective and serotonin-norepinephrine reuptake inhibitors (SSRIs and SNRIs), opioids, antiepileptics, antipsychotics, benzodiazepines, and nonbenzodiazepine receptor agonists ("Z-drugs")]...
October 2023: Drugs & Aging
https://read.qxmd.com/read/37633452/co-prescribing-of-opioids-and-psychotropic-medications-among-medicare-enrolled-older-adults-on-long-term-opioid-therapy
#4
JOURNAL ARTICLE
Shishir Maharjan, Stefan G Kertesz, Kaustuv Bhattacharya, Alayne Markland, Gerald McGwin, Yi Yang, John P Bentley, Sujith Ramachandran
BACKGROUND: Pressures to reduce opioid prescribing have potential to incentivize co-prescribing of opioids (at lower dose) with psychotropic medications. Evidence concerning the extent of the problem is lacking. This study assessed trends in co-prescribing and characterized co-prescribing patterns among Medicare-enrolled older adults with chronic non-cancer pain (CNCP) receiving long-term opioid therapy (LTOT). METHODS: A cohort study was conducted using 2012-2018 5% National Medicare claims data...
August 24, 2023: Journal of the American Pharmacists Association: JAPhA
https://read.qxmd.com/read/37459422/opioid-sparing-strategies-in-arthroscopic-surgery-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
JOURNAL ARTICLE
Seper Ekhtiari, Nicholas Nucci, Fares Uddin, Adeeba Albadran, Aaron Michael Gazendam, Mohit Bhandari, Moin Khan
BACKGROUND: Opioid overprescription is a problem in orthopaedic surgery. Arthroscopic surgery, given its minimally invasive nature, represents an opportunity to minimize opioid prescription and consumption by using effective pain management adjuncts. Thus, the primary question posed in this study was which noninvasive pain management modalities can effectively manage pain and reduce opioid intake after arthroscopic surgery. METHODS: The databases PubMed, MEDLINE, EMBASE, Scopus, and Web of Science were searched on August 10, 2022...
July 1, 2023: JBJS Reviews
https://read.qxmd.com/read/37457785/navigating-the-complex-landscape-of-benzodiazepine-and-z-drug-diversity-insights-from-comprehensive-fda-adverse-event-reporting-system-analysis-and-beyond
#6
JOURNAL ARTICLE
Filip Koniuszewski, Florian D Vogel, Irena Dajić, Thomas Seidel, Markus Kunze, Matthäus Willeit, Margot Ernst
INTRODUCTION: Medications which target benzodiazepine (BZD) binding sites of GABAA receptors (GABAARs) have been in widespread use since the nineteen-sixties. They carry labels as anxiolytics, hypnotics or antiepileptics. All benzodiazepines and several nonbenzodiazepine Z-drugs share high affinity binding sites on certain subtypes of GABAA receptors, from which they can be displaced by the clinically used antagonist flumazenil. Additional binding sites exist and overlap in part with sites used by some general anaesthetics and barbiturates...
2023: Frontiers in Psychiatry
https://read.qxmd.com/read/37381588/treatment-of-insomnia-in-older-adults-recommendations-of-the-polish-sleep-research-society-polish-society-of-family-medicine-and-the-polish-psychiatric-association
#7
Adam Wichniak, Przemysław Bieńkowski, Rafał Dąbrowski, Agnieszka Mastalerz-Migas, Joanna Rymaszewska
Insomnia is one of the most common health problems in developed countries. Its prevalence increases with age, with up to one in two people over the age of 65 experiencing symptoms of insomnia. The older people are also the patients who mostly commonly are among chronic sleep medication users. The aim of this article is to present the current recommendations for the management of insomnia in people over 65 years of age. The recommendations were prepared as a position of an expert panel, which included people from a number of clinical disciplines: family medicine, cardiology, psychiatry, sleep medicine and clinical psychopharmacology...
April 19, 2023: Psychiatria Polska
https://read.qxmd.com/read/37328334/factors-associated-with-guideline-concordant-pharmacological-treatment-for-neuropathic-pain-among-breast-cancer-survivors
#8
JOURNAL ARTICLE
Mrinmayee Lakkad, Bradley Martin, Chenghui Li, Sarah Harrington, Lindsey Dayer, Jacob T Painter
PURPOSE: To identify factors associated with receiving guideline-concordant treatment among breast cancer survivors with neuropathic pain. MATERIALS AND METHODS: A retrospective case-control study was conducted using the SEER-Medicare linked database. We included female breast cancer survivors diagnosed with non-metastatic breast cancer (stages 0-III) between 2007 and 2015 who developed treatment-related neuropathic pain during their survivorship period. Guideline-concordant treatment was defined based on NCCN guidelines...
May 18, 2023: Clinical Breast Cancer
https://read.qxmd.com/read/37285910/high-prescribing-and-state-level-variation-in-z-drug-use-among-medicare-patients
#9
JOURNAL ARTICLE
Kaitlin E Anderson, Rachel I Gifeisman, James L Basting, Donovan J Harris, Antonica R Rajan, Kenneth L McCall, Brian J Piper
BACKGROUND: Z-drugs are nonbenzodiazepine hypnotics used for sleep initiation and maintenance; these drugs increase the risk of fall-related injuries in older adults. The American Geriatrics Society's Beers criteria classifies Z-drugs as high-risk and strongly recommends avoiding prescribing Z-drugs to older adults due to adverse effects. The study objectives were to determine the prevalence of Z-drug prescribing among Medicare Part D patients and identify state or specialty-dependent prescribing differences...
June 7, 2023: Pharmacopsychiatry
https://read.qxmd.com/read/37121956/association-between-the-use-of-suvorexant-and-hip-fracture-in-older-adults-in-japan-using-a-nationwide-administrative-claims-database-a-matched-case-control-study
#10
JOURNAL ARTICLE
Tomoyuki Saito, Shuko Nojiri, Takatoshi Kasai, Yoshimune Hiratsuka, Muneaki Ishijima, Hiroyuki Daida
BACKGROUND AND OBJECTIVE: The use of benzodiazepines and nonbenzodiazepines increases the risk for hip fracture, but the effect of suvorexant, an orexin receptor antagonist, is not clear. The objective of this study was to investigate the association between suvorexant use and hip fractures in older adults. METHODS: A case-control study was conducted using real-world data (RWD) from Medical Data Vision Co., Ltd. with patients hospitalized between January 2019 and December 2020...
April 30, 2023: Drugs & Aging
https://read.qxmd.com/read/36865408/comparative-risk-of-harm-associated-with-zopiclone-or-trazodone-use-in-nursing-home-residents-a-retrospective-cohort-study-in-alberta-canada
#11
JOURNAL ARTICLE
Jennifer A Watt, Susan E Bronskill, Meng Lin, Erik Youngson, Joanne Ho, Brenda Hemmelgarn, Sharon E Straus, Andrea Gruneir
BACKGROUND: There is growing evidence of harm associated with trazodone and nonbenzodiazepine sedative hypnotics (e.g., zopiclone); however, their comparative risk of harm is unknown. METHODS: We conducted a retrospective cohort study with linked health administrative data, which enrolled older (≥66 years old) nursing home residents living in Alberta, Canada, between December 1, 2009, and December 31, 2018; the last follow-up date was June 30, 2019. We compared the rate of injurious falls and major osteoporotic fractures (primary outcome) and all-cause mortality (secondary outcome) within 180 days of first prescription of zopiclone or trazodone with cause-specific hazard models and inverse probability of treatment weights to control for confounding; primary analysis was intention-to-treat and secondary analysis was per-protocol (i...
March 2023: Canadian Geriatrics Journal: CGJ
https://read.qxmd.com/read/36749354/the-abuse-potential-of-lemborexant-a-dual-orexin-receptor-antagonist-according-to-the-8-factors-of-the-controlled-substances-act
#12
REVIEW
Margaret Moline, Shoji Asakura, Carsten Beuckman, Ishani Landry, Beatrice Setnik, Judy Ashworth, Jack E Henningfield
RATIONALE: Lemborexant (LEM) is a dual orexin receptor antagonist (DORA) approved in multiple countries including the USA, Japan, Canada, Australia, and several Asian countries for the treatment of insomnia in adults. As a compound with central nervous system activity, it is important to understand the abuse potential of LEM with respect to public health. OBJECTIVES: This review discusses data for LEM relevant to each of the 8 factors of the United States Controlled Substances Act...
February 7, 2023: Psychopharmacology
https://read.qxmd.com/read/36669239/cerebellar-network-changes-in-depressed-patients-with-and-without-autism-spectrum-disorder-a-case-control-study
#13
JOURNAL ARTICLE
Toshinori Nakamura, Tomoki Kaneko, Daimei Sasayama, Tomonari Yoshizawa, Yoshihiro Kito, Yasunari Fujinaga, Shinsuke Washizuka
Pathophysiological difference of depression in patients with and without autistic spectrum disorder (ASD) has not been investigated previously. Therefore, we sought to determine whether there were differences between non-ASD and ASD groups on resting-state functional magnetic resonance imaging (rs-fMRI) in patients with depression. We performed 3T MRI under resting state in 8 patients with depression and ASD and 12 patients with depression but without ASD. The ASD group showed increased functional connectivity in the cerebellar network of the left posterior inferior temporal gyrus and anterior cerebellar lobes compared to the non-ASD group in an analysis of covariance...
January 16, 2023: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/36467553/the-efficacy-and-safety-of-zaoren-anshen-capsule-in-combination-with-zolpidem-for-insomnia-a-multicentre-randomized-double-blinded-placebo-controlled-trial
#14
JOURNAL ARTICLE
Xiangzhen Zhu, Ming Tao, Haoyu Hu, Jingfang Gao, Jiong Chen, Tiaotiao Lu, Xiaole Wang, Wei Kong, Lijun Lv, Minjun Wei
PURPOSE: Insomnia is the most common sleep disorder with high rate of prevalence, persistence, and leads to negative consequences. The mainstays of insomnia treatment have limitations due to either the side effects of hypnotics or limited accessibility to cognitive behavioral therapy. This study aims to compare the efficacy and safety of the traditional Chinese medicine (TCM) Zaoren Anshen capsule alone or as an adjunct treatment with different doses of the nonbenzodiazepine medication zolpidem tartrate in treating insomnia...
2022: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/36100426/pridinol-for-cancer-related-myofascial-pain
#15
JOURNAL ARTICLE
Séamus Coyle
Myofascial pain is an important yet under recognised component of cancer pain. It has a prevalence of between 11.9 and 44.8% in cancer patients. Treatments for myofascial pain reduce the prevalence of myofascial trigger points therefore decreasing pain and improving range of motion. Pridinol is a nonbenzodiazepine antispasmodic licenced for the treatment of central and peripheral muscle spasms in adults. This paper describes two case histories where patients with myofascial pain were successfully treated with pridinol...
September 13, 2022: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/36041931/real-world-characteristics-and-treatment-patterns-of-patients-with-insomnia-prescribed-trazodone-in-the-united-states
#16
JOURNAL ARTICLE
Ilena Pochiero, Manuela Gorini, Alessandro Comandini, Fabrizio Calisti, Giorgio Di Loreto, Agnese Cattaneo, Tyler Knight, Kathryn P Anastassopoulos, Reema Patel, Rebecca Baik, Oliviero Bruni
PURPOSE: This study sought to describe patient characteristics and treatment patterns among patients with insomnia prescribed trazodone in the United States. METHODS: This real-world, retrospective, descriptive cohort study used US commercial insurance claims from July 1, 2009, through June 30, 2019. The index date was the first prescription for trazodone between January 1, 2010, and December 31, 2018, with 6 months for the preindex period and ≥6 months for the postindex period...
August 2022: Clinical Therapeutics
https://read.qxmd.com/read/35985088/zolpidem-use-and-risk-of-suicide-a-systematic-review-and-meta-analysis
#17
JOURNAL ARTICLE
Hiba Khan, Aakriti Garg, Yasmeen, Nidhi B Agarwal, Deepak Kumar Yadav, Mohd Ashif Khan, Salman Hussain
INTRODUCTION: Zolpidem is one of the most commonly prescribed nonbenzodiazepine hypnotic drugs for insomnia. Published epidemiological studies linked zolpidem with the risk of suicide. However, to date, no meta-analysis investigated this association. Hence, we systematically reviewed and meta-analysed the current evidence from real-world studies reporting the risk of suicide with the use of zolpidem. METHODS: Medline (Ovid), Embase (Ovid), and PsycINFO databases were searched from inception till June 2021 for real-world evidence studies reporting the risk of suicide with the use of zolpidem...
August 11, 2022: Psychiatry Research
https://read.qxmd.com/read/35807172/medications-as-a-trigger-of-sleep-related-eating-disorder-a-disproportionality-analysis
#18
JOURNAL ARTICLE
Diane Merino, Alexandre O Gérard, Elise K Van Obberghen, Nouha Ben Othman, Eric Ettore, Bruno Giordana, Delphine Viard, Fanny Rocher, Alexandre Destere, Michel Benoit, Milou-Daniel Drici
Sleep-related eating disorder (SRED) is a parasomnia with recurrent, involuntary, amnestic eating episodes during sleep. There is growing evidence of the association between SRED and medications. Therefore, we aimed to rank drugs showing the strongest association. VigiBase® (WHO pharmacovigilance database) was queried for all reports of "Sleep-related eating disorder". Disproportionality analysis relied on the Reporting Odds Ratio, with its 95% Confidence Interval (CI), and the Information Component. Our VigiBase® query yielded 676 cases of drug-associated SRED...
July 4, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/35713182/hypnotics-and-infections-disproportionality-analysis-of-the-u-s-food-drug-administration-adverse-event-reporting-system-database
#19
JOURNAL ARTICLE
Long Meng, Jing Huang, Qin He, Yibei Zhao, Wenlong Zhao, Juntao Tan, Shusen Sun, Junqing Yang
STUDY OBJECTIVES: There is no consensus information on infections associated with nonbenzodiazepines. Knowledge about infections related to newly marketed hypnotics (orexin receptor antagonists and melatonin receptor agonists) is scarce. The study aimed to detect infection signals for nonbenzodiazepines, orexin receptor antagonists, and melatonin receptor agonists by analyzing data from the U.S. Food & Drug Administration adverse event reporting system. METHODS: A disproportionality analysis was performed to quantitatively detect infection signals for hypnotics by calculating the reporting odds ratio and the 95% confidence interval...
September 1, 2022: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://read.qxmd.com/read/35575167/efficacy-and-tolerability-of-the-antispasmodic-pridinol-in-patients-with-muscle-pain-results-of-primepain-a-retrospective-analysis-of-open-label-real-world-data-provided-by-the-german-pain-e-registry
#20
JOURNAL ARTICLE
Michael A Überall, Gerhard H H Müller-Schwefe, Johannes Horlemann
OBJECTIVE: To evaluate efficacy and tolerability of the nonbenzodiazepine antispasmodic pridinol (PRI), as an add-on treatment in patients with muscle-related pain (MRP). METHODS: Exploratory retrospective analysis of depersonalized routine data provided by the German Pain e-Registry (GPeR) focusing on pain intensity, pain-related disabilities in daily life, wellbeing, and drug-related adverse events (DRAEs).Primary endpoint based on a global response composite of a) a clinically relevant analgesic response (relative improvement ≥50% and/or absolute improvement ≥ the minimal clinical important difference) for pain intensity and disability in combination with b) an improvement in wellbeing (all at end of treatment vs...
May 14, 2022: Current Medical Research and Opinion
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