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https://www.readbyqxmd.com/read/29328412/therapeutic-efficacy-of-cyclosporin-a-against-spinal-cord-injury-in-rats-with-hyperglycemia
#1
Zhi-Rong Chen, Yi Ma, Hao-Hui Guo, Zhi-Dong Lu, Qun-Hua Jin
The present study aimed to explore the therapeutic effects of cyclosporin A (CsA) on spinal cord injury (SCI) in rats with hyperglycemia and to identify a novel potential method to treat SCI in the presence of hyperglycemia. Female Sprague‑Dawley (SD) rats were randomly allocated into four groups: Sham, SCI, SCI+hyperglycemia and SCI+hyperglycemia+CsA groups. Streptozotocin‑induced hyperglycemic SD rats and a weight‑drop contusion SCI model were established. The Basso, Beattie, Bresnahan scale and inclined plane test were used to evaluate the neurological function of the rats...
January 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29318411/cyclophilin-a-increases-cd68-cell-infiltration-in-rat-experimental-periodontitis
#2
Lande Xue, Linwang Su, Li Zhao, Jianxia Li, Yi Du, Xijiao Yu
Cyclophilin A (CyPA) is a potent chemokine, which can directly induce leukocyte chemotaxis and contribute to the pathogenesis of inflammation-mediated diseases. This study is to observe the expression and distribution of CyPA and CD68+ cells in the histopathogenesis of rat ligation-induced experimental periodontitis, and assess the role of CyPA in CD68+ cell infiltration in rat experimental periodontitis. Experimental periodontitis was induced by ligation according to our previous method. CyPA expression in gingival tissues was detected by western blotting...
January 9, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29314720/correlation-of-april-with-production-of-inflammatory-cytokines-during-acute-malaria-in-the-brazilian-amazon
#3
Raquel A Pinna, Adriana C Dos Santos, Daiana S Perce-da-Silva, Luciene A da Silva, Rodrigo N R da Silva, Marcelo R Alves, Fátima Santos, Joseli de Oliveira Ferreira, Josué C Lima-Junior, Déa M Villa-Verde, Paula M De Luca, Carla E Carvalho-Pinto, Dalma M Banic
INTRODUCTION: A proliferation-inducing ligand (APRIL) and B cell activation factor (BAFF) are known to play a significant role in the pathogenesis of several diseases, including BAFF in malaria. The aim of this study was to investigate whether APRIL and BAFF plasma concentrations could be part of inflammatory responses associated with P. vivax and P. falciparum malaria in patients from the Brazilian Amazon. METHODS: Blood samples were obtained from P. vivax and P...
January 3, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29312608/april-promotes-non-small-cell-lung-cancer-growth-and-metastasis-by-targeting-erk1-2-signaling
#4
Hengli Dou, Zhaohua Yan, Meng Zhang, Xiaoxin Xu
Non-small-cell lung cancer (NSCLC) is the major subtype of lung cancer, which is the most common cause of cancer-related mortality in the world. It is a complex disease involving multiple genetic alterations. As a cytokine belonging to the Tumor Necrosis Factor-α (TNF- α) family, the - a proliferation-inducing ligand (APRIL) expression and its signaling have been studied in many human solid tumor types, but the data on APRIL signaling in NSCLC are lacking. The aim of this study was to evaluate the APRIL expression and investigate its signaling in NSCLC...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29302888/overexpression-of-aryl-hydrocarbon-receptor-ahr-signalling-pathway-in-human-meningioma
#5
Noble Kumar Talari, Manas K Panigrahi, Sailaja Madigubba, Prakash Babu Phanithi
Aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor and involved in tumorigenesis of many cancers. However there are no reports on AHR in human meningioma. Therefore we examined the status of the AHR and its signalling molecules in human meningioma by using tumor biopsy samples and autopsy control meninges. We report the up regulation of AHR pathway genes like aryl hydrocarbon receptor nuclear translocator (ARNT), aldehyde dehydrogenase1family memberA3 (ALDH1A3), cytochrome P450, family1, subfamily A polypeptide1 (CYP1A1) and TCCD induced poly ADP ribose polymerase (TIPARP) gene expression in human meningioma...
January 4, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29288949/synthesis-and-evaluation-of-2-3-arylureido-pyridines-and-2-3-arylureido-pyrazines-as-potential-modulators-of-a%C3%AE-induced-mitochondrial-dysfunction-in-alzheimer-s-disease
#6
Ahmed Elkamhawy, Jung-Eun Park, Ahmed H E Hassan, Ae Nim Pae, Jiyoun Lee, Beoung-Geon Park, Eun Joo Roh
A series of 2-(3-arylureido)pyridines and 2-(3-benzylureido)pyridines were synthesized and evaluated as potential modulators for amyloid beta (Aβ)-induced mitochondrial dysfunction in Alzheimer's disease (AD). The blocking activities of forty one small molecules against Aβ-induced mitochondrial permeability transition pore (mPTP) opening were evaluated by JC-1 assay which measures the change of mitochondrial membrane potential (ΔΨm). The inhibitory activity of twenty five compounds against Aβ-induced mPTP opening was superior to that of the standard cyclosporin A (CsA)...
December 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29285285/ginseng-rh2-protects-endometrial-cells-from-oxygen-glucose-deprivation-re-oxygenation
#7
Xiao-Fang Tang, Hai-Yan Liu, Ling Wu, Min-Hui Li, Shu-Ping Li, Hong-Bin Xu
In this study, oxygen glucose deprivation/re-oxygenation (OGDR) was applied to cultured endometrial cells to mimic ischemic-reperfusion injuries. We also tested the potential effect of Ginseng Rh2 (GRh2) against the process. In established T-HESC human endometrial cells and primary murine endometrial cells, GRh2 largely inhibited OGDR-induced viability reduction and cell death. Remarkably, OGDR induced programmed necrosis in the endometrial cells, evidenced by cyclophilin D-p53-adenine nucleotide translocator 1 (ANT-1) mitochondrial association, mitochondrial depolarization, reactive oxygen species production, and lactate dehydrogenase release...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29282865/membrane-localization-of-a-myb3-transcription-factor-regulated-by-a-tvcyp1-cyclophilin-in-the-parasitic-protozoan-trichomonas-vaginalis
#8
Chien-Hsin Chu, Yu-Hsin Huang, Hsing-Wei Liu, Hong-Ming Hsu, Jung-Hsiang Tai
In Trichomonas vaginalis, a TvCyP1 cyclophilin was previously demonstrated to regulate the nuclear translocation of Myb1 and Myb3, which respectively repress and activate transcription of an adhesion protein ap65-1 gene. In the present study, TvCyP1 was found to bind to Myb3 at sites spanning 54 Gly-Pro55 and 72 Gly-Pro73 with differential affinities. When Gly54 and Gly72 in Myb3 were both mutated, the mutant protein was restrained on outer membranes of hydrogenosomes and some cytoplasmic vesicles. In purified Myb3 protein complex, a high-molecular-weight Myb3-interacting protein (Myb3IPhmw ) and a 72-kDa heat shock protein (TvHSP72) were identified and characterized, with direct binding of Myb3 to Myb3IPhmw and TvHSP72 confirmed in vitro...
December 28, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29281037/central-administration-of-cyclosporine-a-decreases-ethanol-drinking
#9
Patrick J Ronan, Sydney A Strait, Geralyn M Palmer, Thomas P Beresford
Aims: Abstinence among alcohol dependent liver graft recipients is remarkably high. The routine use of anti-immune agents in these patients led to rodent studies showing that immunosuppressants acting through inhibition of calcineurin (CLN) are highly effective in decreasing alcohol consumption. It remained unclear, however, whether the decreased alcohol consumption in rodent models is mediated through peripheral suppression of immune response or centrally through direct inhibition of cyclophilin-CLN in the brain...
December 21, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29277559/pan-genotype-hepatitis-e-virus-replication-in-stem-cell-derived-hepatocellular-systems
#10
Xianfang Wu, Viet Loan Dao Thi, Peng Liu, Constantin N Takacs, Kuanhui Xiang, Linda Andrus, Jérôme Gouttenoire, Darius Moradpour, Charles M Rice
BACKGROUND & AIMS: The 4 genotypes of hepatitis E virus (HEV) that infect humans (genotypes 1-4) vary in geographical distribution, transmission, and pathogenesis. Little is known about the properties of HEV or its hosts that contribute to these variations. Primary isolates grow poorly in cell culture; most studies have relied on variants adapted to cancer cell lines, which likely alter virus biology. We investigated the infection and replication of primary isolates of HEV in hepatocyte-like cells (HLCs) derived from human embryonic and induced pluripotent stem cells...
December 22, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29249587/correlations-of-serum-cyclophilin-a-and-melatonin-concentrations-with-hypertension-induced-left-ventricular-hypertrophy
#11
Hongyan Su, Tongshuai Chen, Jingyuan Li, Jie Xiao, Shujian Wang, Xiaobin Guo, Peili Bu
BACKGROUND AND AIMS: Cyclophilin A (CyPA) is an abundantly expressed pro-inflammatory cytokine and a major secreted oxidative stress-induced factor (SOXF). Melatonin is an important chronobiological regulatory molecule that is mainly released from the pineal gland and exerts antioxidant effects by acting as a radical scavenger. Based on accumulating evidence, both CyPA and melatonin play important roles in cardiovascular diseases. However, further investigations are required to determine whether CyPA and melatonin are associated with hypertension-induced left ventricular hypertrophy (LVH)...
December 14, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29249267/coronaviruses-and-arteriviruses-display-striking-differences-in-their-cyclophilin-a-dependence-during-replication-in-cell-culture
#12
Adriaan H de Wilde, Jessika C Zevenhoven-Dobbe, Corrine Beugeling, Udayan Chatterji, Danielle de Jong, Philippe Gallay, Karoly Szuhai, Clara C Posthuma, Eric J Snijder
Cyclophilin A (CypA) is an important host factor in the replication of a variety of RNA viruses. Also the replication of several nidoviruses was reported to depend on CypA, although possibly not to the same extent. These prior studies are difficult to compare, since different nidoviruses, cell lines and experimental set-ups were used. Here, we investigated the CypA dependence of three distantly related nidoviruses that can all replicate in Huh7 cells: the arterivirus equine arteritis virus (EAV), the alphacoronavirus human coronavirus 229E (HCoV-229E), and the betacoronavirus Middle East respiratory syndrome coronavirus (MERS-CoV)...
December 14, 2017: Virology
https://www.readbyqxmd.com/read/29230844/cyclophilin-d-promotes-tubular-cell-damage-and-the-development-of-interstitial-fibrosis-in-the-obstructed-kidney
#13
Weiping Hou, Khai G Leong, Elyce Ozols, Greg H Tesch, David J Nikolic-Paterson, Frank Y Ma
Cyclophilin D (CypD) is an important component in mitochondrial-dependent tubular cell death in acute kidney injury. However, it is not known whether CypD contributes to tubular cell damage in chronic interstitial fibrosis. We investigated this question in the unilateral ureter obstruction (UUO) model of renal interstitial fibrosis. Groups of CypD-/- and wild type (WT) mice were killed 7 or 12 days after UUO surgery. The significant tubular cell apoptosis seen in WT UUO was significantly reduced in CypD-/- UUO based on TUNEL and cleaved caspase 3 staining...
December 12, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29226135/a-novel-cyclophilin-b-gene-in-the-red-tide-dinoflagellate-cochlodinium-polykrikoides-molecular-characterizations-and-transcriptional-responses-to-environmental-stresses
#14
Sofia Abassi, Hui Wang, Bum Soo Park, Jong-Woo Park, Jang-Seu Ki
The marine dinoflagellate Cochlodinium polykrikoides is one of the most common ichthyotoxic species that causes harmful algal blooms (HABs), which leads to ecological damage and huge economic loss in aquaculture industries. Cyclophilins (CYPs) belong to the immunophilin superfamily, and they may play a role in the survival mechanisms of the dinoflagellate in stress environments. In the present study, we identified a novel cyclophilin gene from C. polykrikoides and examined physiological and gene transcriptional responses to biocides copper sulphate (CuSO4) and sodium hypochlorite (NaOCl)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29194430/human-cytomegalovirus-encoded-mir-us25-1-5p-attenuates-cd147-emmprin-mediated-early-antiviral-response
#15
Jun Chen, Sisi Xia, Xiangmin Yang, Huizi Chen, Fanni Li, Fenyong Liu, Zhinan Chen
Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection. However, the involvement of type-I transmembrane glycoprotein CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) in the antiviral response to HCMV infection is still unknown. Here, we demonstrated the specific knockdown of CD147 significantly decreased HCMV-induced activation of NF-κB and Interferon-beta (IFN-β), which contribute to the cellular antiviral responses...
December 1, 2017: Viruses
https://www.readbyqxmd.com/read/29188056/molecular-cloning-expression-purification-and-functional-characterization-of-an-antifungal-cyclophilin-protein-from-panax-ginseng
#16
Hui Zhang, Jiawen Wang, Shuaijun Li, Siming Wang, Meichen Liu, Weinan Wang, Yu Zhao
Cyclophilins (CyPs), a member of peptidyl-prolyl cis-trans isomerases (PPIases), are ubiquitously distributed in organisms such as bacteria, yeast, plants and animals. CyPs have diverse biological functions, with some exhibiting antifungal and antiviral activities. In this study, Panax ginseng cyclophilin (pgCyP), a novel gene encoding an antifungal protein from Panax ginseng, was cloned, and its protein product was expressed in Escherichia coli, and then fractionated by affinity chromatography. The open reading frame of the pgCyP full-length coding sequence was found to encode a single-domain CyP-like protein of 174 amino residues with a calculated molecular weight of 18...
December 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29187540/a-general-model-for-retroviral-capsid-pattern-recognition-by-trim5-proteins
#17
Jonathan M Wagner, Devin E Christensen, Akash Bhattacharya, Daria M Dawidziak, Marcin D Roganowicz, Yueping Wan, Ruth A Pumroy, Borries Demeler, Dmitri N Ivanov, Barbie K Ganser-Pornillos, Wesley I Sundquist, Owen Pornillos
Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, organizes, and protects the viral genome. TRIM5α uses a SPRY domain to bind capsids with low intrinsic affinity (KD >1 mM), and therefore requires higher-order assembly into a hexagonal lattice to generate sufficient avidity for productive capsid recognition. TRIMCyp, on the other hand, binds HIV-1 capsids through a cyclophilin A domain, which has a well-defined binding site and higher (KD ∼10 μM) affinity for isolated capsid subunits...
November 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29182321/macrocycle-conformational-sampling-by-dft-d3-cosmo-rs-methodology
#18
Ondrej Gutten, Daniel Bím, Jan Řezáč, Lubomir Rulisek
To find and calibrate a robust and reliable computational protocol for mapping conformational space of medium-sized molecules, exhaustive conformational sampling has been carried out for the series of seven macrocyclic compounds of varying ring size and one acyclic analogue. While five of them were taken from the MD/LLMOD/force-field study by Shelley and coworkers (J. Chem. Inf. MODEL: 2014, 54, 2680), three represent potential macrocyclic inhibitors of human cyclophilin A. The free energy values (GDFT/COSMO-RS) for all conformers of each compound were obtained by the composite protocol based on the in vacuo quantum mechanics (DFT-D3 method in a large basis set), standard gas-phase thermodynamics and the COSMO-RS solvation model (QM+COSMO-RS)...
November 28, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29163824/targeting-cyclophilin-d-by-compound-19-protects-neuronal-cells-from-oxygen-glucose-deprivation-re-oxygenation
#19
Jinyu Zheng, Enhui Cui, Haikou Yang, Mao Li, Jing Zhou, Ming Yan, Jian Sun, De-Rong Tang
Oxygen and glucose deprivation (OGD) with re-oxygenation (OGDR) is applied to neuronal cells to mimic ischemia-reperfusion injuries. Activation of cyclophilin D (Cyp-D)-dependent programmed necrosis pathway mediates OGDR-induced neuronal cell damages. Here, we tested the potential effect of Compound 19 (C19), a novel Cyp-D inhibitor, in this process. In both established neuronal cell lines (Neuro-2a and NB41A3 cells) and the primary murine CA1 hippocampal neurons, pretreatment with C19 largely attenuated OGDR-induced cell viability reduction and cell death...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146974/human-cyclophilin-b-forms-part-of-a-multi-protein-complex-during-erythrocyte-invasion-by-plasmodium-falciparum
#20
Prem Prakash, Mohammad Zeeshan, Ekta Saini, Azhar Muneer, Sachin Khurana, Bishwanath Kumar Chourasia, Arunaditya Deshmukh, Inderjeet Kaur, Surabhi Dabral, Niharika Singh, Zille Anam, Ayushi Chaurasiya, Shikha Kaushik, Pradeep Dahiya, Md Kalamuddin, Jitendra Kumar Thakur, Asif Mohmmed, Anand Ranganathan, Pawan Malhotra
Invasion of human erythrocytes by Plasmodium falciparum merozoites involves multiple interactions between host receptors and their merozoite ligands. Here we report human Cyclophilin B as a receptor for PfRhopH3 during merozoite invasion. Localization and binding studies show that Cyclophilin B is present on the erythrocytes and binds strongly to merozoites. We demonstrate that PfRhopH3 binds to the RBCs and their treatment with Cyclosporin A prevents merozoite invasion. We also show a multi-protein complex involving Cyclophilin B and Basigin, as well as PfRhopH3 and PfRh5 that aids the invasion...
November 16, 2017: Nature Communications
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