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https://www.readbyqxmd.com/read/29676570/caznos-nd-3-emits-tissue-penetrating-near-infrared-light-upon-force-loading
#1
Lejing Li, Lothar Wondraczek, Lihua Li, Yu Zhang, Ye Zhu, Mingying Peng, Chuanbin Mao
Mechanoluminescent (ML) materials are mechano-optical converters that can emit light under an external mechanical stimulus. All the existing ML materials can only emit light from near ultraviolet to red, which is outside the near-infrared (NIR) windows desired for biomechanical imaging. No studies have been done on doping rare earth (RE) ions with photoluminescence (PL) in the NIR region into a compound to form a ML material that emits NIR light in response to an external force. Here, we show that doping RE ions with a NIR PL into an inorganic compound does not usually result in the formation of a NIR ML material, which can only be achieved in the combination of Nd3+ ions and a CaZnOS compound among the combinations we studied...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29675886/photoregulating-of-stretchability-and-toughness-of-a-self-healable-polymer-hydrogel
#2
Chenxiao Xiong, Lidong Zhang, Meiran Xie, Ruyi Sun
Supramolecular hydrogels that are assembled through dynamic host-guest interactions have presented apparent potential in the construction of materials with promising performance. Herein, a photoregulated hydrogel cross-linked by host-guest interactions with multifunctions of high stretchability, strong toughness, and rapid self-healing property is reported. The hydrogel exhibits unique light-responsive property due to the introduction of two photoisomerized groups. For example, the stress-strain curve of the original hydrogel indicates 1020% rupture strain with the maximum tensile strain value of 214 kPa...
April 20, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29674564/observing-the-cell-in-its-native-state-imaging-subcellular-dynamics-in-multicellular-organisms
#3
Tsung-Li Liu, Srigokul Upadhyayula, Daniel E Milkie, Ved Singh, Kai Wang, Ian A Swinburne, Kishore R Mosaliganti, Zach M Collins, Tom W Hiscock, Jamien Shea, Abraham Q Kohrman, Taylor N Medwig, Daphne Dambournet, Ryan Forster, Brian Cunniff, Yuan Ruan, Hanako Yashiro, Steffen Scholpp, Elliot M Meyerowitz, Dirk Hockemeyer, David G Drubin, Benjamin L Martin, David Q Matus, Minoru Koyama, Sean G Megason, Tom Kirchhausen, Eric Betzig
True physiological imaging of subcellular dynamics requires studying cells within their parent organisms, where all the environmental cues that drive gene expression, and hence the phenotypes that we actually observe, are present. A complete understanding also requires volumetric imaging of the cell and its surroundings at high spatiotemporal resolution, without inducing undue stress on either. We combined lattice light-sheet microscopy with adaptive optics to achieve, across large multicellular volumes, noninvasive aberration-free imaging of subcellular processes, including endocytosis, organelle remodeling during mitosis, and the migration of axons, immune cells, and metastatic cancer cells in vivo...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29673226/evaluation-of-over-the-row-harvester-damage-in-a-super-high-density-olive-orchard-using-on-board-sensing-techniques
#4
Manuel Pérez-Ruiz, Pilar Rallo, M Rocío Jiménez, Miguel Garrido-Izard, M Paz Suárez, Laura Casanova, Constantino Valero, Jorge Martínez-Guanter, Ana Morales-Sillero
New super-high-density (SHD) olive orchards designed for mechanical harvesting using over-the-row harvesters are becoming increasingly common around the world. Some studies regarding olive SHD harvesting have focused on the effective removal of the olive fruits; however, the energy applied to the canopy by the harvesting machine that can result in fruit damage, structural damage or extra stress on the trees has been little studied. Using conventional analyses, this study investigates the effects of different nominal speeds and beating frequencies on the removal efficiency and the potential for fruit damage, and it uses remote sensing to determine changes in the plant structures of two varieties of olive trees (‘Manzanilla Cacereña’ and ‘Manzanilla de Sevilla’) planted in SHD orchards harvested by an over-the-row harvester...
April 17, 2018: Sensors
https://www.readbyqxmd.com/read/29665206/defect-free-highly-uniform-washable-transparent-electrodes-induced-by-selective-light-irradiation
#5
Zhaoyang Zhong, Kyoohee Woo, Inhyuk Kim, Hyuntae Kim, Pyeongsam Ko, Dongwoo Kang, Sin Kwon, Hyunchang Kim, Hongseok Youn, Jooho Moon
A simple route to fabricate defect-free Ag-nanoparticle-carbon-nanotube composite-based high-resolution mesh flexible transparent conducting electrodes (FTCEs) is explored. In the selective photonic sintering-based patterning process, a highly soft rubber or thin plastic substrate is utilized to achieve close and uniform contact between the composite layer and photomask, with which uniform light irradiation can be obtained with diminished light diffraction. This well-controlled process results in developing a fine and uniform mesh pattern (≈12 μm)...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29661352/effects-of-alpinetin-on-intestinal-barrier-function-inflammation-and-oxidative-stress-in-dextran-sulfate-sodium-induced-ulcerative-colitis-mice
#6
Yue Tan, Changqing Zheng
BACKGROUND: Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata that has demonstrated anti-inflammatory, antibacterial and anti-tumor activities. However, alpinetin has not been widely studied in amelioration of inflammatory bowel disease. The study aimed to investigate the role of alpinetin on intestinal epithelial tight junctions, oxidative stress and Nrf2/HO-1 signaling pathway in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. METHODS: A total of 40 mice were divided into 5 groups (n = 8/group): control group, DSS group (received 3% DSS), and low, medium and high-dose treatment groups (3% DSS + alpinetin 25, 50 and 100mg/kg)...
April 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29655867/short-term-sleep-deprivation-with-exposure-to-nocturnal-light-alters-mitochondrial-bioenergetics-in-drosophila
#7
Nathane Rosa Rodrigues, Giulianna Echeverria Macedo, Illana Kemmerich Martins, Karen Kich Gomes, Nélson Rodrigues de Carvalho, Thaís Posser, Jeferson Luis Franco
Many studies have shown the effects of sleep deprivation in several aspects of health and disease. However, little is known about how mitochondrial bioenergetics function is affected under this condition. To clarify this, we developed a simple model of short-term sleep deprivation, in which fruit-flies were submitted to a nocturnal light condition and then mitochondrial parameters were assessed by high resolution respirometry (HRR). Exposure of flies to constant light was able to alter sleep patterns, causing locomotor deficits, increasing ROS production and lipid peroxidation, affecting mitochondrial activity, antioxidant defense enzymes and caspase activity...
April 12, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29652515/structure-and-function-of-the-26s-proteasome
#8
Jared A M Bard, Ellen A Goodall, Eric R Greene, Erik Jonsson, Ken C Dong, Andreas Martin
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The proteasome's cellular functions range from general protein homeostasis and stress response to the control of vital processes such as cell division and signal transduction. To reliably process all the proteins presented to it in the complex cellular environment, the proteasome must combine high promiscuity with exceptional substrate selectivity...
April 13, 2018: Annual Review of Biochemistry
https://www.readbyqxmd.com/read/29652479/a-thermal-water-and-near-infrared-light-induced-shape-memory-composite-based-on-polyvinyl-alcohol-and-polyaniline-fibers
#9
Yongkang Bai, Jiwen Zhang, Xin Chen
A multiresponsive shape memory composite was prepared by incorporating polyaniline (PAn) fibers into polyvinyl alcohol (PVA), where in situ polymerization assisted by surfactant was used to homogeneously disperse PAn fibers in a PVA matrix. The PAn fibers not only increased physical cross-linking points in the system but also served as photothermal conversion reagents, resulting in excellent water-, thermal-, and near-infrared (NIR) light-induced shape memory properties of the composites, where their light-induced shape recovery ratio and speed could be enhanced via the increase of PAn loading percentage and light power density...
April 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29650295/acquired-von-willebrand-syndrome-and-impaired-platelet-function-during-venovenous-extracorporeal-membrane-oxygenation-rapid-onset-and-fast-recovery
#10
Johannes Kalbhenn, Axel Schlagenhauf, Simone Rosenfelder, Axel Schmutz, Barbara Zieger
BACKGROUND: Bleeding contributes to the high mortality of venovenous extracorporeal membrane oxygenation (vvECMO). The development of acquired von Willebrand syndrome (AVWS) has been identified as relevant pathology during ECMO. This study was performed to determine the onset of AVWS after implantation and the recovery of von Willebrand factor (VWF) parameters after explantation of ECMO in a large cohort of patients. METHODS: VWF parameters of 59 patients treated with vvECMO at a university ECMO center were obtained before ECMO implantation, during therapy, and after explantation...
March 17, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29648443/shedding-light-on-the-molecular-pathology-of-amyloid-plaques-in-transgenic-alzheimer-s-disease-mice-using-multimodal-maldi-imaging-mass-spectrometry
#11
Ibrahim Kaya, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder
Senile plaques formed by aggregated amyloid β peptides are one of the major pathological hallmarks of Alzheimer's disease (AD) which have been suggested to be the primary influence triggering the AD pathogenesis and the rest of the disease process. However, neurotoxic Aβ aggregation and progression are associated with a wide range of enigmatic biochemical, biophysical and genetic processes. MALDI imaging mass spectrometry (IMS) is a label-free method to elucidate the spatial distribution patterns of intact molecules in biological tissue sections...
April 12, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29629297/influences-of-pinpoint-plantar-long-wavelength-infrared-light-irradiation-stress-free-therapy-on-chorioretinal-hemodynamics-atherosclerosis-factors-and-vascular-endothelial-growth-factor
#12
Keisou Ishimaru, Takuma Nakajima, Yoshihisa Namiki, Kenji Ryotokuji
Background: We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) is useful for alleviating insulin resistance and improving intracranial blood flow in patients with type 2 diabetes mellitus. This study was undertaken to evaluate the influences of SFT on chorioretinal hemodynamics (retinal artery and vein blood flows) as well as atherosclerosis-related factors (TG, LDL-C) and VEGF in patients with dyslipidemia. Methods: Four patients with dyslipidemia received 15-minute irradiation with a stress-free apparatus (far-infrared wavelength, 30 mW)...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29627732/responses-of-grapevine-rootstocks-to-drought-through-altered-root-system-architecture-and-root-transcriptomic-regulations
#13
Kubilay Yıldırım, Adem Yağcı, Seda Sucu, Sümeyye Tunç
Roots are the major interface between the plant and various stress factors in the soil environment. Alteration of root system architecture (RSA) (root length, spread, number and length of lateral roots) in response to environmental changes is known to be an important strategy for plant adaptation and productivity. In light of ongoing climate changes and global warming predictions, the breeding of drought-tolerant grapevine cultivars is becoming a crucial factor for developing a sustainable viticulture. Root-trait modeling of grapevine rootstock for drought stress scenarios, together with high-throughput phenotyping and genotyping techniques, may provide a valuable background for breeding studies in viticulture...
March 31, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29625931/development-and-validation-of-a-stability-indicating-rp-hplc-fld-method-for-determination-of-5-4-chlorophenoxy-methyl-1-3-4-oxadiazole-2-thiol-a-novel-drug-candidate
#14
Naureen Shehzadi, Khalid Hussain, Muhammad Islam, Nadeem Irfan Bukhari, Noman Asif, Muhammad Tanveer Khan, Muhammad Salman, Shaista Qamar, Sajida Parveen, Fakhra Zahid, Arshad Ali Shah, Abida Bilal, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Azizur Rehman
The present study describes the development and validation of a simple high performance liquid chromatographic method for the determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1, 3, 4-oxadiazole-2-thiol. The stability-indicating capacity of the method was evaluated by subjecting the compound's solution to hydrolytic, oxidative, photolytic, transition metal- and thermal- stress. The chromatographic separation was achieved over a C18 column (Promosil, 5 µm, 4.60 × 250 mm), maintained at 25°C, using an isocratic mobile phase comprising a mixture of acetonitrile and acidified water of pH 2...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29623085/non-native-minnows-threaten-quillwort-populations-in-high-mountain-shallow-lakes
#15
Esperança Gacia, Teresa Buchaca, Nayeli Bernal-Mendoza, Ibor Sabás, Enric Ballesteros, Marc Ventura
Submersed aquatic plants are a key component of shallow, clear water lakes contributing to primary production and water quality. High mountain lakes are naturally fishless although invasive trout and most recently minnows have been introduced causing a major impact on fauna richness. The Pyrenean high mountain range has preserved soft-water oligotrophic boreal isoetids in their southern limit of distribution but the recent fish introduction is a potential factor of stress that needs to be addressed. We here work under the hypothesis that due to contrasting ecological features, trout will not be heavily affecting quillwort populations while minnows will have a stronger effect on zooplankton and zoobenthos that will promote algal growth and reduce light availability for the underwater meadows...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29622671/metabolic-regulation-of-photosynthetic-membrane-structure-tunes-electron-transfer-function
#16
REVIEW
Matthew P Johnson
The photosynthetic chloroplast thylakoid membrane of higher plants is a complex three-dimensional structure that is morphologically dynamic on a timescale of just a few minutes. The membrane dynamics are driven by the phosphorylation of light-harvesting complex II (LHCII) by the STN7 kinase, which controls the size of the stacked grana region relative to the unstacked stromal lamellae region. Here, I hypothesise that the functional significance of these membrane dynamics is in controlling the partition of electrons between photosynthetic linear and cyclic electron transfer (LET and CET), which determines the ratio of NADPH/ATP produced...
April 5, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29609042/the-primate-fovea-structure-function-and-development
#17
REVIEW
Andreas Bringmann, Steffen Syrbe, Katja Görner, Johannes Kacza, Mike Francke, Peter Wiedemann, Andreas Reichenbach
A fovea is a pitted invagination in the inner retinal tissue (fovea interna) that overlies an area of photoreceptors specialized for high acuity vision (fovea externa). Although the shape of the vertebrate fovea varies considerably among the species, there are two basic types. The retina of many predatory fish, reptilians, and birds possess one (or two) convexiclivate fovea(s), while the retina of higher primates contains a concaviclivate fovea. By refraction of the incoming light, the convexiclivate fovea may function as image enlarger, focus indicator, and movement detector...
March 30, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29604522/comparative-adventitious-root-development-in-pre-etiolated-and-flooded-arabidopsis-hypocotyls-exposed-to-different-auxins
#18
Cibele Tesser da Costa, Marcos Letaif Gaeta, Jorge Ernesto de Araujo Mariath, Remko Offringa, Arthur Germano Fett-Neto
Adventitious roots (ARs) emerge from stems, leaves or hypocotyls, being strategic for clonal propagation. ARs may develop spontaneously, upon environmental stress or hormonal treatment. Auxins strongly influence AR development (ARD), depending on concentration and kind. However, the role of different types of auxin is rarely compared at the molecular level. Rooting triggered by light exposure and flooding was examined in intact etiolated Arabidopsis thaliana hypocotyls treated with distinct auxin types. Morphological aspects, rooting-related gene expression profiles, and IAA immunolocalization were recorded...
March 21, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29604305/oral-exposure-to-silver-nanoparticles-increases-oxidative-stress-markers-in-the-liver-of-male-rats-and-deregulates-the-insulin-signalling-pathway-and-p53-and-cleaved-caspase-3-protein-expression
#19
Jordi Blanco, Sarah Tomás-Hernández, Tania García, Miquel Mulero, Mercedes Gómez, Jose L Domingo, Domènec J Sánchez
The present study was aimed at assessing the impact of AgNPs on the liver of male rats orally exposed to 0, 50, 100 and 200 mg/kg/day of polyvinyl pyrrolidone coated AgNPs (PVP-AgNPs) for 90 days. The induction of apoptotic cell death -by measuring the protein levels of the active form of caspase 3- and the levels of the microtubule-associated protein 1A/1B-light chain (LC3) protein were measured as a marker of the induction of autophagy. PVP-AgNPs caused an increase of the activity of superoxide dismutase (SOD) and catalase (CAT) in the liver of male rats...
March 28, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29603665/uv-radiation-oxidative-stress-affects-eye-health
#20
REVIEW
Iliya V Ivanov, Timo Mappes, Patrick Schaupp, Christian Lappe, Siegfried Wahl
In the eye ultraviolet radiation (UVR) is not known to contribute to visual perception but to mainly damage multiple structures. UVR carries higher energy than visible light and high dose exposure to UVR causes direct cellular damage, which has an important role in the development of cancer. This review provides an overview on the most recent knowledge on the role of UVR in oxidative stress (OS) in relation to non-cancer ocular pathologies: various corneal pathologies, cataract, glaucoma, and age-related macular degeneration...
March 30, 2018: Journal of Biophotonics
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