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Keywords malignant cancer radiotherapy ...

malignant cancer radiotherapy radiation oncology

https://read.qxmd.com/read/38479176/research-progress-in-mcm-family-focus-on-the-tumor-treatment-resistance
#1
REVIEW
Yuxuan Tian, Yanhong Zhou, Fuxin Chen, Siyi Qian, Xingming Hu, Bin Zhang, Qiang Liu
Malignant tumors constitute a significant category of diseases posing a severe threat to human survival and health, thereby representing one of the most challenging and pressing issues in the field of biomedical research. Due to their malignant nature, which is characterized by a high potential for metastasis, rapid dissemination, and frequent recurrence, the prevailing approach in clinical oncology involves a comprehensive treatment strategy that combines surgery with radiotherapy, chemotherapy, targeted drug therapies, and other interventions...
March 12, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38433950/stereotactic-body-radiotherapy-for-oligoprogression-with-or-without-switch-of-systemic-therapy
#2
JOURNAL ARTICLE
Jonas Willmann, Eugenia Vlaskou Badra, Selma Adilovic, Maiwand Ahmadsei, Sebastian M Christ, Stephanie Tanadini-Lang, Michael Mayinger, Matthias Guckenberger, Nicolaus Andratschke
BACKGROUND: Oligoprogression is defined as cancer progression of a limited number of metastases under active systemic therapy. The role of metastasis-directed therapy, using stereotactic body radiotherapy (SBRT), is controversial as is the continuation versus switch of systemic therapy. We report outcomes of oligoprogressive patients after SBRT, and compare those patients that continued or switched their current line of systemic therapy. MATERIAL/METHODS: We included patients who developed up to 5 progressive extracranial metastases under systemic therapy for any solid organ malignancy and were treated with SBRT to all lesions at our institution between 01/2014 and 12/2019...
March 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38423627/current-status-of-prostate-specific-membrane-antigen-targeted-alpha-radioligand-therapy-in-prostate-cancer
#3
REVIEW
Gaku Yamamichi, Taigo Kato, Tadashi Watabe, Koji Hatano, Motohide Uemura, Norio Nonomura
Prostate cancer (PCa) is the most prevalent malignancy and leading cause of mortality in men. Despite the development of various drugs, such as novel androgen receptor signaling inhibitors and poly adenosine diphosphate-ribose polymerase inhibitors targeting homologous recombination repair-related genetic mutations, prognosis of metastatic castration-resistant prostate cancer remains unfavorable. However, recent advances in nuclear medicine have allowed for both imaging diagnostics and therapeutic interventions by targeting molecules specifically expressed in cancer cells with radioisotopes (RI)...
March 2024: Anticancer Research
https://read.qxmd.com/read/38415359/practice-changing-clinical-trials-in-radiation-oncology-for-gastrointestinal-malignancies-in-2021-2023
#4
REVIEW
J Boustani, F Huguet, V Vendrely
Gastrointestinal cancers are one of the most frequent cancers and a leading cause of cancer deaths worldwide. We provide an overview of the most important practice-changing trials that were either published or presented at the international scientific meetings in 2021-2023. Highlights included reports on three phase III trials (CONCORDE/PRODIGE 26, ARTDECO, and a study by Xu et al.) that evaluated dose escalation in the definitive setting for locally advanced oesophageal cancers, as well as two phase III trials that evaluated the role of chemotherapy (neo-AEGIS) and targeted therapy (NRG/RTOG 1010) in the neoadjuvant setting for adenocarcinoma oesophageal cancers or gastroesophageal junction cancer...
December 2023: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://read.qxmd.com/read/38343705/thoracic-spinal-metastasis-with-hip-flexion-failure-and-psoas-muscle-atrophy-successfully-improved-with-radiotherapy-a-case-report
#5
Satoshi Teramura, Yojiro Ishikawa, Kengo Ito, Takayuki Yamada
When a malignant tumor infiltrates the psoas muscle, it is termed malignant psoas syndrome (MPS). We are reporting this case because the malignancy led to atrophy of the psoas muscle, and the clinical course differed from the typical presentation of MPS. A 72-year-old Japanese female with advanced sigmoid colon cancer and multiple metastases had been undergoing systemic chemotherapy for four years. She complained of severe back pain on a numeric rating scale (NRS) of 4-5, left groin pain, and hip flexion weakness...
February 2024: Curēus
https://read.qxmd.com/read/38328840/infrared-thermal-imaging-control-of-radiation-dermatitis-dynamics
#6
JOURNAL ARTICLE
L Miroshnichenko, L Vasiliev, G Shustakova, E Gordiyenko, Yu Fomenko, I Dunaieva
BACKGROUND: Radiation-induced dermatitis impairs the quality of life of cancer patients and may lead to the need of interrupting radiotherapy. The grade of dermatitis is subjectively assessed by the visual examination. There is an urgent need for both objective and quantitative methods for assessing the current grade of dermatitis and predicting its severity at an early stage of radiotherapy. AIM: The aim of the study was to evaluate the advantages and limitations of infrared thermography for monitoring the current level of radiation-induced dermatitis and predicting its severity by quantitative analysis of the thermal field dynamics in the irradiated zone...
February 3, 2024: Experimental Oncology
https://read.qxmd.com/read/38309330/frequency-of-radiotherapy-induced-malignancies-in-li-fraumeni-syndrome-patients-with-early-stage-breast-cancer-and-influence-of-the-radiotherapy-technique
#7
JOURNAL ARTICLE
Vanessa Petry, Renata Colombo Bonadio, Karina Moutinho, Luiz Senna Leite, Laura Testa, Daniela J B Heinemann Cohn, Allyne Carneiro Cagnacci, Veronica Eh Kim, Maria Del Pilar Estevez-Diz, Maria Candida Barrisson Villares Fragoso
INTRODUCTION: Breast cancer (BC) is the most common malignancy in female patients with Li-Fraumeni Syndrome (LFS), a condition associated with an increased risk of various malignancies, including radiotherapy-induced malignancies (RIM) within previously irradiated areas. Our study aimed to assess the incidence of RIM in LFS patients with early-stage breast cancer (eBC) treated with adjuvant radiotherapy (RT), including the impact of RT dose and technique. METHODS: We examined patients with a germline pathogenic/likely pathogenic TP53 variant diagnosed with eBC and monitored by a Hereditary Cancer Team at a single cancer center...
February 1, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38305836/hypofractionated-versus-conventional-fractionation-external-beam-radiotherapy-in-intermediate-and-high-risk-localized-prostate-cancer
#8
JOURNAL ARTICLE
Eileen Samuel, Saliha Zaman, Muhammad Abu Bakar, Muhammad Mohsin Fareed
BACKGROUND: Prostate cancer is the second most common malignancy in men, and its incidence is increasing which is attributed to increased screening programs. The treatment options of intermediate and high risk prostate cancer include radical prostatectomy, radiotherapy and androgen deprivation therapy. Hypofractionated radiotherapy is becoming more popular lately due to better understanding of the radiobiology of prostate cancer and favorable logistics. OBJECTIVE: To compare the toxicity and efficacy of hypofractionated versus conventional fractionation external beam radiotherapy in patients with intermediate and high risk localized prostate cancer treated in Shaukat Khanum Memorial Hospital and Research Center, Lahore (SKMCH & RC)...
February 2, 2024: Discover. Oncology
https://read.qxmd.com/read/38300402/paradigm-shifting-research-key-studies-in-urologic-oncology
#9
JOURNAL ARTICLE
Shawn Dason, Cheryl T Lee
BACKGROUND: Genitourinary malignancies have a substantial impact on men and women in the USA as they include three of the ten most common cancers (prostate, renal, and bladder). Other urinary tract cancers are less common (testis and penile) but still have profound treatment implications related to potential deficits in sexual, urinary, and reproductive function. Evidenced-based practice remains the cornerstone of treatment for urologic malignancies. METHODS: The authors reviewed the literature in consideration of the four top articles influencing clinical practice in the prior calendar year, 2022...
February 1, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38263828/paediatric-radiotherapy-in-the-united-kingdom-an-evolving-subspecialty-and-a-paradigm-for-integrated-teamworking-in-oncology
#10
JOURNAL ARTICLE
Amy Colori, Raymond Ackwerh, Yen-Ch'ing Chang, Kristy Cody, Cathy Dunlea, Jennifer E Gains, Trevor Gaunt, Callum M S Gillies, Claire Hardy, Narinder Lalli, Pei S Lim, Carmen Soto, Mark N Gaze
Many different malignancies occur in children, but overall, cancer in childhood is rare. Survival rates have improved appreciably and are higher compared with most adult tumour types. Treatment schedules evolve as a result of clinical trials and are typically complex and multi-modality, with radiotherapy an integral component of many. Risk stratification in paediatric oncology is increasingly refined, resulting in a more personalized use of radiation. Every available modality of radiation delivery: simple and advanced photon techniques, proton beam therapy, molecular radiotherapy, and brachytherapy, have their place in the treatment of children's cancers...
January 23, 2024: British Journal of Radiology
https://read.qxmd.com/read/38259678/survival-analysis-and-correlates-with-molecular-epidemiology-10-year-retrospective-series-of-high-grade-glioma-in-pakistan
#11
JOURNAL ARTICLE
Mashal Shah, Saad Bin Anis, Irfan Yusuf, Mohammad Hamza Bajwa
INTRODUCTION: High-grade gliomas are malignant, recurring primary central nervous system (CNS) tumors requiring extensive postoperative chemotherapy and radiation treatment. Isocitrate dehydrogenase (IDH), 1p19q, and ATRX mutations significantly influence survival and response to chemotherapy, as seen in many extensive studies from the Global North. This study aims to report data from the local region regarding progression-free survival and overall survival in light of molecular characteristics...
2024: Journal of cancer & allied specialties
https://read.qxmd.com/read/38249809/predicting-long%C3%A2-term-survival-following-involved-site-radiotherapy-for-oligometastases
#12
JOURNAL ARTICLE
Johnny Kao, Patricia Eckardt, Jennifer Mceachron, Christopher Atalla, Ashish Sangal
The majority of cancer-associated mortalities are due to distant metastases, and systemic therapy alone is generally not curative. Patients with oligometastases are amenable to involved site radiotherapy with the possibility of long-term disease-free survival; however, prognostic factors remain poorly defined. The present retrospective, single institution study consisted of consecutive adult patients with oligometastases from solid tumor malignancy referred to a single high volume radiation oncologist between January 2014 and December 2021...
February 2024: Oncology Letters
https://read.qxmd.com/read/38233306/characteristics-and-outcomes-of-cardiac-rehabilitation-patients-with-and-without-cancer-insights-from-western-sydney
#13
JOURNAL ARTICLE
Matthew Hollings, Nicole Gordon, Julie Redfern, Liza Thomas, Anna Singleton, Qiang Tu, Robert Zecchin
AIM: Increased cardiovascular events are common in cancer survivors and contribute to an emerging cardio-oncology patient group requiring secondary prevention strategies including cardiac rehabilitation (CR). This study aimed to compare characteristics and outcomes for patients participating in CR with and without an existing cancer diagnosis. METHOD: Observational cohort study including consecutive patients enrolled in a single-centre outpatient CR program in Western Sydney between 2018-2022...
January 16, 2024: Heart, Lung & Circulation
https://read.qxmd.com/read/38205571/a-prospective-study-of-the-incidence-of-chronic-xerostomia-and-the-quality-of-life-in-patients-undergoing-radiotherapy-for-head-and-neck-malignancies-with-imrt-or-vmat-techniques
#14
JOURNAL ARTICLE
Nishant Gaurav Pathak, Mahadev P, Yash Alok
BACKGROUND: Radiation therapy in Head and neck cancers often leads to xerostomia which often leads to a decline in quality of life. The aim of the study was to compare xerostomia among cancer patients undergoing IMRT and VMAT techniques for head and neck malignancies and follow them up via quality of life assessment. METHODOLOGY: It was a hospital based prospective study with follow up at 0, 3 and 6 months among total 80 patients divided in 2 groups of VMAT and IMRT respectively...
January 2024: Gulf Journal of Oncology
https://read.qxmd.com/read/38191096/neoadjuvant-reirradiation-for-radiotherapy-associated-angiosarcoma-of-the-breast
#15
JOURNAL ARTICLE
Wafa Asha, Zahraa Al-Hilli, Risal Djohan, G Thomas Budd, Elizabeth Obi, Erica Fleming-Hall, Kailin Yang, Stephen Grobmyer, Sheen Cherian, Rahul Tendulkar, Chirag Shah
PURPOSE: Radiation-associated angiosarcoma of the breast (RAASB) is a rare side effect following breast conserving therapy (BCT) and has been associated with poor outcomes. At this time, there is no consensus regarding management of RAASB and the role of reirradiation remains controversial. We present our modern institutional outcomes in managing RAASB with incorporation of neoadjuvant hyperfractionated reirradiation. METHODS: Patients identified were treated between 2016 and 2020 with inclusion of any histologically proven RAASB without metastatic disease at diagnosis, while excluding those with a history of radiotherapy (RT) outside of the breast/chest wall, or other sarcoma histologies...
January 6, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38179406/update-on-current-diagnosis-and-management-of-anaplastic-thyroid-carcinoma
#16
REVIEW
Efstathios T Pavlidis, Ioannis N Galanis, Theodoros E Pavlidis
Well-differentiated thyroid carcinoma has a favorable prognosis with a 5-year survival rate of over 95%. However, the undifferentiated or anaplastic type accounting for < 0.2%, usually in elderly individuals, exhibits a dismal prognosis with rapid growth and disappointing outcomes. It is the most aggressive form of thyroid carcinoma, with a median survival of 5 mo and poor quality of life (airway obstruction, dysphagia, hoarseness, persistent pain). Early diagnosis and staging are crucial. Diagnostic tools include biopsy (fine needle aspiration, core needle, open surgery), high-resolution ultrasound, computed tomography, magnetic resonance imaging, [(18)F]fluoro-D-glucose positron emission tomo-graphy/computed tomography, liquid biopsy and microRNAs...
December 24, 2023: World Journal of Clinical Oncology
https://read.qxmd.com/read/38153521/effect-of-radiation-therapy-on-patients-with-stage-t3-or-t4-malignant-phyllodes-tumors-a-retrospective-observational-study-based-on-seer
#17
JOURNAL ARTICLE
Gongyin Zhang, Ping Yang, Jinsheng Zeng, Changlong Wei
PURPOSE: Among all primary breast tumors, malignant phyllodes tumor of the breast (MPTB) make up less than 1%. In the treatment of phyllode tumors, surgical procedures such as mastectomy and breast-conserving surgery are the mainstay. MPTB has, however, been controversial when it comes to treating it with RT. We aimed to explore the prognostic impact of RT and other clinicopathologic factors on long-term survival for patients with stage T3 or T4 malignant phyllodes tumors. METHODS: We select patients with stage T3 or T4 MPTB who qualified for the criteria between 2000 and 2018 via the Surveillance, Epidemiology, and End Results (SEER) database...
December 28, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38144534/long-term-disease-free-survival-following-comprehensive-involved-site-radiotherapy-for-oligometastases
#18
JOURNAL ARTICLE
Johnny Kao, Michelle Sahagian, Vani Gupta, Symeon Missios, Ashish Sangal
INTRODUCTION: Despite recent advances in drug development, durable complete remissions with systemic therapy alone for metastatic cancers remain infrequent. With the development of advanced radiation technologies capable of selectively sparing normal tissues, patients with oligometastases are often amenable to comprehensive involved site radiotherapy with curative intent. This study reports the long-term outcomes and patterns of failure for patients treated with total metastatic ablation often in combination with systemic therapy...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38132364/an-analysis-of-clinical-and-systemic-factors-associated-with-palliative-radiotherapy-delivery-and-completion-at-the-end-of-life-in-alberta-canada
#19
JOURNAL ARTICLE
Siddhartha Goutam, Sunita Ghosh, Jordan Stosky, Alexander Tam, Sarah Quirk, Alysa Fairchild, Jackson Wu, Marc Kerba
Radiotherapy (RT) is often utilized for symptom control at the end of life. Palliative RT (pRT) may not be taken to completion by patients, thus decreasing clinical benefits and adversely impacting resource allocation. We determined rates of incomplete pRT and examined predictors of non-completion using an electronic questionnaire. Methods: A questionnaire was embedded within the RT electronic prescribing system for all five cancer centers of Alberta, Canada, between 2017 and 2020. Prescribing radiation oncologists (ROs) were tasked with completing the questionnaire...
November 21, 2023: Current Oncology
https://read.qxmd.com/read/38106724/comparison-of-acute-gastrointestinal-toxicity-of-intensity-modulated-radiotherapy-versus-three-dimensional-conformal-radiotherapy-in-patients-of-carcinoma-cervix
#20
JOURNAL ARTICLE
Sanjukta Padhi, Bikash Ranjan Mahapatra, Kartik Chandra Pati, Bijayalaxmi Sahoo, Satyabrata Kanungo, Tanushree Mishra, Anupam Muraleedharan
Introduction Cervical cancer is the most common gynaecological malignancy worldwide, with a higher prevalence in middle- and low-income countries. Chemoradiotherapy, followed by intracavitary brachytherapy, is the treatment of choice in locally advanced cervical cancer. The most common acute side effect of external beam radiotherapy (EBRT) is bowel toxicity in the form of diarrhoea and abdominal cramps. The treatment techniques of EBRT were revolutionised with the advent of intensity modulation. This study aims to prospectively analyse whether the dosimetric advantage of intensity-modulated radiotherapy (IMRT) over three-dimensional conformal radiotherapy (3DCRT) is translated clinically into a decrease in acute toxicity...
November 2023: Curēus
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