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malignant cancer radiotherapy radiation oncology

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https://www.readbyqxmd.com/read/28469334/clinical-profile-of-pediatric-oncology-patients-treated-by-external-beam-radiotherapy-an-institutional-experience
#1
Virender Suhag, B S Sunita, Pankaj Vats, Arti Sarin, A K Singh, Mayuri Jain
INTRODUCTION: Pediatric tumors are a heterogeneous group of malignant conditions requiring multimodal treatment, and management of such cases is at time challenging. We present the clinical profile of pediatric cancer patients who received radiation, either alone or as adjuvant to surgery and chemotherapy; in prophylactic, radical or palliative clinical setting. AIM: This study was envisaged to review our experience of pediatric oncology cases, their clinical and morphological profile, dosage schedule of radiotherapy, and the therapy induced complications...
January 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28387011/radiotherapy-in-anaplastic-thyroid-carcinoma-an-australian-experience
#2
Kevin So, Robin E Smith, Sidney R Davis
INTRODUCTION: Anaplastic thyroid cancer is a rare and fatal malignancy, associated with significant local tumour and often treatment related morbidity. We report our experience in treating this cancer over a 20-year period. METHODS: A retrospective review of prospectively collected data from a single Australian Institution (Alfred Health Radiation Oncology) was carried out on patients referred with anaplastic thyroid carcinoma between 1992 and 2013. RESULTS: Thirty patients (17 females and 13 males) were identified with a median age at presentation of 72 years...
April 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28355688/-a-randomized-study-of-intensity-modulated-radiation-therapy-versus-three-dimensional-conformal-radiation-therapy-for-pelvic-radiation-in-patients-of-post-operative-treatment-with-gynecologic-malignant-tumor
#3
J Ni, Z M Yin, S H Yuan, N F Liu, L Li, X X Xu, H M Lou
Objective: To study the difference between intensity-modulated radiation therapy (IMRT) and three dimensional conformal radiation therapy (3D-CRT) for pelvic radiation of post-operative treatment with gynecologic malignant tumor. Methods: A prospective investigation study was conducted on 183 patients of post-operative patients with whole pelvic radiation therapy of cervical cancer or endometrial cancer in Zhejiang Cancer Hospital [IMRT group (n=85) and 3D-CRT group (n=98)] from Oct. 2015 to Oct. 2016. The two groups received same dose (45 Gy in 25 fractions)...
March 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28355119/high-intensity-focused-ultrasound-for-the-treatment-of-prostate-cancer-a-review
#4
Christian G Chaussy, Stefan Thüroff
Over the past 25 years, the average life expectancy for men has increased almost 4 years, and the age of prostate cancer detection has decreased an average of 10 years with diagnosis increasingly made at early-stage disease where curative therapy is possible. These changing trends in the age and extent of malignancy at diagnosis have revealed limitations in conventional curative therapies for prostate cancer, including a significant risk of aggressive cancer recurrence, and the risk of long-term genitourinary morbidity and its detrimental impact on patient's quality of life (QOL)...
April 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28263446/reirradiation-of-head-and-neck-cancer-long-term-disease-control-and-toxicity
#5
Wouter T C Bots, Sven van den Bosch, Ellen M Zwijnenburg, Tim Dijkema, Guido B van den Broek, Willem L J Weijs, Lia C G Verhoef, Johannes H A M Kaanders
BACKGROUND: The purpose of this study was to report long-term disease control and late radiation toxicity for patients reirradiated for head and neck cancer. METHODS: We conducted a retrospective analysis of 137 patients reirradiated with a prescribed dose ≥45 Gy between 1986 and 2013 for a recurrent or second primary malignancy. Endpoints were locoregional control, overall survival (OS), and grade ≥4 late complications according to European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) criteria...
March 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28181815/onsite-versus-offsite-radiation-treatment-of-malignant-spinal-cord-compression-lessons-from-a-safety-net-health-system
#6
COMPARATIVE STUDY
Albert C Chen, Mark D Bonnen, Henry Mok
OBJECTIVE: Metastatic spinal cord compression (MSCC) is an oncologic emergency that often warrants emergent treatment; but, it is unclear whether radiation treatment (RT) can be optimally managed from an offsite radiotherapy facility. METHODS: Patient charts from consecutive patients with MSCC who were treated with radiotherapy alone at either an onsite hospital radiation department (from 2008 to 2012) or an offsite radiotherapy centre (2012-2015) were reviewed...
April 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28008773/radiotherapy-response-evaluation-using-fdg-pet-ct-established-and-emerging-applications
#7
REVIEW
Helen Cliffe, Chirag Patel, Robin Prestwich, Andrew Scarsbrook
Radiation therapy is a common component of curative cancer treatment. However, there is a significant incidence of treatment failure. In these cases, salvage surgical options are sometimes appropriate. Accurate assessment of response and early recognition of treatment success or failure is therefore critical to guide treatment decisions and impacts on survival and the morbidity of treatment. Traditionally, treatment response has depended upon the anatomical measurement of disease. However, this may not correlate well with the presence of disease, especially after radiotherapy...
March 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/27648280/long-term-outcomes-following-post-operative-radiotherapy-for-stage-i-ii-testicular-seminoma-an-australasian-single-institution-experience
#8
Wee Loon Ong, Lester Nazareth, Benjamin Hindson, Bronwyn Matheson, Jeremy L Millar
INTRODUCTION: The aim of the study is to review the long-term oncological outcomes and adverse effects of post-operative radiotherapy (PORT) for Stage I/II seminoma patients in an Australian radiation treatment centre. METHODS: This is a retrospective study of 125 patients with Stage I/II seminoma treated with PORT at the Alfred Health Radiation Oncology Service between 1992 and 2013. Patients were linked to the Victorian Cancer Registry to enable confirmation of survival and diagnosis of secondary malignancies (SM)...
September 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27599685/-sarcoma-developed-in-irradiated-area-preliminary-results-of-the-sari-trial
#9
P Maingon, C Mirjolet, I Diallo, C Veres, F Collin, A Italiano, F Chibon, J L Merlin, J M Coindre
Radiotherapy and surgery are the two main pillars of the locoregional treatment of cancer. The risk of second malignancy is better evaluated and constitutes a major issue regarding radioprotection of the patients. Among malignant disease observed in the surviving irradiated patients, the occurrence of sarcoma is a rare event but associated with a poor outcome since the 5 year overall survival is estimated at 10 to 35 %. The SARI protocol, written in 2011, included 120 patients and 240 controlled patients, irradiated in the same conditions but without sarcoma observed during the follow up...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27563457/clinical-outcomes-and-toxicities-of-proton-radiotherapy-for-gastrointestinal-neoplasms-a-systematic-review
#10
Vivek Verma, Steven H Lin, Charles B Simone, Minesh P Mehta
BACKGROUND: Proton beam radiotherapy (PBT) is frequently shown to be dosimetrically superior to photon radiotherapy (RT), though supporting data for clinical benefit are severely limited. Because of the potential for toxicity reduction in gastrointestinal (GI) malignancies, we systematically reviewed the literature on clinical outcomes (survival/toxicity) of PBT. METHODS: A systematic search of PubMed, EMBASE, abstracts from meetings of the American Society for Radiation Oncology, Particle Therapy Co-Operative Group, and American Society of Clinical Oncology was conducted for publications from 2000-2015...
August 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/27514316/combined-modality-therapy-for-thoracic-and-head-and-neck-cancers-a-review-of-updated-literature-based-on-a-consensus-meeting
#11
REVIEW
Pierfrancesco Franco, Alba Fiorentino, Francesco Dionisi, Michele Fiore, Silvia Chiesa, Stefano Vagge, Francesco Cellini, Luciana Caravatta, Mario Tombolini, Fiorenza De Rose, Icro Meattini, Gianluca Mortellaro, Giuseppina Apicella, Lorenza Marino, Daniela Greto
PURPOSE: Combined modality therapy is a mainstay option for thoracic malignancies and head and neck cancers. The integration of different strategies is based on the multidisciplinary approach of modern clinical oncology. Radiation oncologists have to be educated, trained, and updated to provide state-of-the-art care to cancer patients and thus educational meetings are crucial. METHODS: The Italian Association of Radiation Oncology Young Members Working Group (AIRO Giovani) organized its 8th national meeting, focused on combination therapy in lung, esophageal, and head and neck cancer (with a specific focus on larynx-preservation strategies for larynx/hypopharynx tumors), involving young professionals working in Italy...
October 13, 2016: Tumori
https://www.readbyqxmd.com/read/27500710/proton-radiotherapy-for-gynecologic-neoplasms
#12
REVIEW
Vivek Verma, Charles B Simone, Andrew O Wahl, Sushil Beriwal, Minesh P Mehta
BACKGROUND: Proton beam therapy (PBT) is increasingly being used globally to treat a variety of malignancies. This is the first review assessing PBT for gynecologic neoplasms. Dose distribution to organs-at-risk (OARs), particularly bone marrow (BM), is addressed. Clinical outcomes and toxicity data are detailed. MATERIAL AND METHODS: Systematic searches of PubMed, EMBASE, abstracts from meetings of the American Society for Radiation Oncology, Particle Therapy Co-Operative Group, and American Society of Clinical Oncology were conducted for publications...
November 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27486283/prognostic-factors-in-primary-vaginal-cancer-a-single-institute-experience-and-review-of-literature
#13
Chelakkot G Prameela, Rahul Ravind, Bharath C Gurram, V S Sheejamol, Makuny Dinesh
BACKGROUND: Primary vaginal carcinoma is rare, accounting for 1-2 % of all gynecological malignancies. Being rare, most observations are based on retrospective and comparative analyses. This study was aimed to retrospectively analyze the prognostic factors and its relevance in the outcomes of primary vaginal cancers. MATERIALS: Medical records of all cases of primary vaginal cancers, presented to Department of Oncology, from 2004 to 2012, at a tertiary care center in southern India, were retrieved from electronic medical records, and were analyzed...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27389786/the-evolving-and-future-role-of-taxanes-in-squamous-cell-carcinomas-of-the-head-and-neck-a-review
#14
Mayur D Mody, Harpaul S Gill, Nabil F Saba
IMPORTANCE: Since their discovery in the 1970s, taxanes have maintained widespread clinical use in solid tumors, including squamous cell carcinoma of the head and neck (SCCHN), but SCCHN remains a difficult malignancy to treat, often requiring a multidisciplinary approach involving surgery, radiotherapy, and chemotherapy. Taxanes have been heavily studied in the treatment of SCCHN, and their use is currently in the setting of induction chemotherapy with the TPF (docetaxel, FU, cisplatin) regimen for locally advanced SCCHN, as well as in the concurrent therapy setting...
September 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27318682/molecular-targeting-of-integrins-and-integrin-associated-signaling-networks-in-radiation-oncology
#15
Anne Vehlow, Katja Storch, Daniela Matzke, Nils Cordes
Radiation and chemotherapy are the main pillars of the current multimodal treatment concept for cancer patients. However, tumor recurrences and resistances still hamper treatment success regardless of advances in radiation beam application, particle radiotherapy, and optimized chemotherapeutics. To specifically intervene at key recurrence- and resistance-promoting molecular processes, the development of potent and specific molecular-targeted agents is demanded for an efficient, safe, and simultaneous integration into current standard of care regimens...
2016: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27317102/urological-reconstruction-after-pelvic-oncological-surgery-a-single-institution-experience
#16
Yu Guang Tan, Grace Tan, David Tan, Claramae S Chia, Dun Yong Ang, Melissa C C Teo
BACKGROUND: In locally advanced pelvic malignancies, there is often involvement of urological organs, necessitating resection and reconstruction, which can be associated with significant complications. METHODS: We retrospectively reviewed 20 patients undergoing urological reconstructions during pelvic oncological surgeries from January 2004 to December 2013. All patients had imaging-proven involvement of at least one urological organ preoperatively. Primary outcome was urological complication rate...
June 14, 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27257417/survey-on-gynecological-cancer-treatment-by-piedmont-liguria-and-valle-d-aosta-group-of-airo-italian-association-of-radiation-oncology
#17
Gabriella Cattari, Elena Delmastro, Sara Bresciani, Sergio Gribaudo, Antonella Melano, Flavio Giannelli, Maria Tessa, Renato Chiarlone, Tindaro Scolaro, Marco Krengli, Alessandro Urgesi, Pietro Gabriele
PURPOSE: We focused the attention on radiation therapy practices about the gynecological malignancies in Piedmont, Liguria, and Valle d'Aosta to know the current treatment practice and to improve the quality of care. MATERIAL AND METHODS: We proposed a cognitive survey to evaluate the standard practice patterns for gynecological cancer management, adopted from 2012 to 2014 by radiotherapy (RT) centers with a large amount of gynecological cancer cases. There were three topics: 1...
April 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27158579/lung-metastasis-in-a-case-of-recurrent-poorly-differentiated-leiomyosarcoma-of-the-bartholin-gland-a-case-report-and-review-of-the-literature
#18
Fatimah Alnafisah, Joanne Alfieri
Vulvar neoplasms represent four percent of all gynecological cancers. While most cases of vulvar neoplasms are benign, two percent of patients present with malignant disease. We present the case of a 37-year-old premenopausal female who presented to an outside institution with a lump in her left vulva, which had progressively enlarged to the size of an egg. A wide local excision of the left vulva was performed, and the pathology revealed a high-grade sarcoma, not otherwise specified (NOS), with negative margins...
2016: Curēus
https://www.readbyqxmd.com/read/27133229/three-radiation-induced-metachronous-pelvic-tumors-in-a-patient-who-underwent-radiotherapy-for-cervical-cancer-a-case-report
#19
Marijo Boban, Snjezana Tomic, Marija Sulic, Eduard Vrdoljak
INTRODUCTION: Patients treated with radiotherapy are under increased long-term risk of developing radiation-induced tumors. In this report we present an exceptionally rare case of a patient who, following radiotherapy for cervical cancer, developed 3 radiation-induced metachronous pelvic tumors. CASE PRESENTATION: In 1997, a 37-year-old patient with cervical adenocarcinoma (FIGO stage IB2) was subjected to adjuvant conventionally fractionated external-beam radiation therapy and brachytherapy following surgical treatment...
November 11, 2016: Tumori
https://www.readbyqxmd.com/read/27093891/radiation-induced-tumor-lysis-syndrome-in-chronic-lymphocytic-leukemia
#20
Ali Alkan, Tuğçe Kütük, Ebru Karcı, Arzu Yaşar, Ayşe Hiçsönmez, Güngör Utkan
Tumor lysis syndrome (TLS) is an important oncological emergency that is usually observed with hematological malignancies and rarely with solid tumors. It can be induced either by therapy or spontaneously. Radiotherapy-induced TLS has been rarely reported in the literature. Here we present a patient with a diagnosis of metastatic prostate cancer and chronic lymphocytic leukemia complicated with TLS during palliative radiotherapy.
September 5, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
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