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https://www.readbyqxmd.com/read/28067284/oleanolic-acid-ameliorates-high-glucose-induced-endothelial-dysfunction-via-ppar%C3%AE-activation
#1
Zihui Zhang, Manli Jiang, Xinya Xie, Haixia Yang, Xinfeng Wang, Lei Xiao, Nanping Wang
Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a pentacyclic triterpenes widely distributed in food, medicinal plants and nutritional supplements. OA exhibits various pharmacological properties, such as hepatoprotective and anti-tumor effects. In this study, we analyzed the effect of OA on endothelial dysfunction induced by high glucose in human vascular endothelial cells (ECs). Western blotting showed that OA attenuated high glucose-reduced nitric production oxide (NO) as well as Akt-Ser(473) and eNOS-Ser(1177) phosphorylation in cultured human umbilical vein ECs (HUVECs)...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056052/the-glucocorticoid-receptor-regulates-the-angptl4-gene-in-a-ctcf-mediated-chromatin-context-in-human-hepatic-cells
#2
Masafumi Nakamoto, Ko Ishihara, Takehisa Watanabe, Akiyuki Hirosue, Shinjiro Hino, Masanori Shinohara, Hideki Nakayama, Mitsuyoshi Nakao
Glucocorticoid signaling through the glucocorticoid receptor (GR) plays essential roles in the response to stress and in energy metabolism. This hormonal action is integrated to the transcriptional control of GR-target genes in a cell type-specific and condition-dependent manner. In the present study, we found that the GR regulates the angiopoietin-like 4 gene (ANGPTL4) in a CCCTC-binding factor (CTCF)-mediated chromatin context in the human hepatic HepG2 cells. There are at least four CTCF-enriched sites and two GR-binding sites within the ANGPTL4 locus...
2017: PloS One
https://www.readbyqxmd.com/read/28045438/d11-mediated-inhibition-of-protein-kinase-ck2-impairs-hif-1%C3%AE-mediated-signaling-in-human-glioblastoma-cells
#3
Susanne Schaefer, Tina H Svenstrup, Mette Fischer, Barbara Guerra
Compelling evidence indicates that protein kinase CK2 plays an important role in many steps of cancer initiation and progression, therefore, the development of effective and cell-permeable inhibitors targeting this kinase has become an important objective for the treatment of a variety of cancer types including glioblastoma. We have recently identified 1,3-dichloro-6-[(E)-((4-methoxyphenyl)imino)methyl]dibenzo(b,d)furan-2,7-diol (D11) as a potent and selective inhibitor of protein kinase CK2. In this study, we have further characterized this compound and demonstrated that it suppresses CK2 kinase activity by mixed type inhibition (KI 7...
January 1, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28025036/decreased-eicosapentaenoic-acid-levels-in-acne-vulgaris-reveals-the-presence-of-a-proinflammatory-state
#4
İbrahim Aslan, Filiz Özcan, Taner Karaarslan, Ebru Kıraç, Mutay Aslan
This study aimed to determine circulating levels of polyunsaturated fatty acids (PUFAs), secretory phospholipase A2 (sPLA2), lipoprotein lipase (LPL) and measure circulating protein levels of angiopoietin-like protein 3 (ANGPTL3), ANGPTL4, cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in patients with acne vulgaris. Serum from 21 control subjects and 31 acne vulgaris patients were evaluated for levels of arachidonic acid (AA, C20:4n- 6), dihomo-gamma-linolenic acid (DGLA, C20:3n-6), eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3)...
December 23, 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28004575/whole-milk-increases-intestinal-angptl4-expression-and-excretion-of-fatty-acids-through-feces-and-urine
#5
Søren Drud Nielsen, Bashar Amer, Karoline Blaabjerg, Trine K Dalsgaard, Randi Jessen, Bjørn Petrat-Melin, Martin Krøyer Rasmussen, Hanne D Poulsen, Jette F Young
The angiopoietin-like 4 (ANGPLT4) protein is involved in lipid metabolism and is known to inhibit lipoprotein lipase in the bloodstream. We investigated the effect of milk on intestinal ANGPTL4 and the metabolic profile of growing pigs and the effect of free fatty acids (FFAs) on ANGPTL4 in ex vivo and in vitro assays. Feeding pigs whole milk increased intestinal ANGPTL4 mRNA and increased fecal excretion of long-chain FFA compared to the control group fed soybean oil (n = 9). Furthermore, FFAs (C4-C8) induced ANGPTL4 gene expression in porcine intestinal tissue mounted in Ussing chambers and ANGPTL4 protein secretion to both the apical and basolateral sides of intestinal Caco-2 cells on permeable membranes...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27989982/meta-analysis-of-microarray-based-expression-profiles-to-identify-differentially-expressed-genes-in-intracranial-aneurysms
#6
Zhe Xu, Hao Li, Jiangman Song, Bing Han, Zheng Wang, Yong Cao, Shuo Wang, Jizong Zhao
OBJECTIVE: To gain comprehensive insight into the molecular mechanism of formation and rupture of intracranial aneurysms (IAs). METHODS: All the publicly accessible microarray-based whole-genome gene expression profiles on IAs were retrieved. The significance analysis of microarrays method was applied to identify differentially expressed genes (DEGs). Functional annotation was performed using gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses...
October 27, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27984852/biochemical-analysis-of-the-lipoprotein-lipase-truncation-variant-lpl-s447x-reveals-increased-lipoprotein-uptake
#7
Cassandra K Hayne, Michael J Lafferty, Brian J Eglinger, John P Kane, Saskia B Neher
Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipoproteins. Whereas most identified mutations in the LPL gene are deleterious, one mutation, LPL(S447X), causes a gain of function. This mutation truncates two amino acids from LPL's C-terminus. Carriers of LPL(S447X) have decreased VLDL levels and increased HDL levels, a cardioprotective phenotype. LPL(S447X) is used in Alipogene tiparvovec, the gene therapy product for individuals with familial LPL deficiency. It is unclear why LPL(S447X) results in a serum lipid profile more favorable than that of LPL...
January 9, 2017: Biochemistry
https://www.readbyqxmd.com/read/27959692/variants-in-angptl4-and-the-risk-of-coronary-artery-disease
#8
LETTER
Allan D Sniderman, George Thanassoulis
No abstract text is available yet for this article.
8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959691/variants-in-angptl4-and-the-risk-of-coronary-artery-disease
#9
LETTER
Alanna C Morrison, Yi-Ping Fu, Christopher J O'Donnell
No abstract text is available yet for this article.
8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959690/variants-in-angptl4-and-the-risk-of-coronary-artery-disease
#10
LETTER
(no author information available yet)
No abstract text is available yet for this article.
8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27933182/angiopoietin-like-protein-4-and-cardiovascular-function-in-copd
#11
B Waschki, A M Kirsten, O Holz, T Meyer, R Lichtinghagen, K F Rabe, H Magnussen, T Welte, H Watz, S Janciauskiene
INTRODUCTION: The coexistence of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) is frequent and might be inter-related through inflammation-related processes reflected by specific markers. Here, we studied angiopoietin-like protein 4 (ANGPTL4), an upcoming cardiovascular marker, in stable COPD, and its relationship to cardiovascular function with respect to well-known CVD risk factors. METHODS: In a prospective COPD cohort study, we investigated serum ANGPTL4 levels, vascular status (ankle-brachial index (ABI)) and cardiac function (N-terminal pro-B-type natriuretic peptide (NT-proBNP)) as well as airflow limitation, objectively measured physical activity, the metabolic syndrome, high-sensitive C reactive protein (hs-CRP) and other CVD risk factors at 2 time points...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27929370/the-angiopoietin-like-protein-angptl4-catalyzes-unfolding-of-the-hydrolase-domain-in-lipoprotein-lipase-and-the-endothelial-membrane-protein-gpihbp1-counteracts-this-unfolding
#12
Simon Mysling, Kristian Kølby Kristensen, Mikael Larsson, Oleg Kovrov, André Bensadouen, Thomas Jd Jørgensen, Gunilla Olivecrona, Stephen G Young, Michael Ploug
Lipoprotein lipase (LPL) undergoes spontaneous inactivation via global unfolding and this unfolding is prevented by GPIHBP1 (Mysling et al., 2016). We now show: (1) that ANGPTL4 inactivates LPL by catalyzing the unfolding of its hydrolase domain; (2) that binding to GPIHBP1 renders LPL largely refractory to this inhibition; and (3) that both the LU domain and the intrinsically disordered acidic domain of GPIHBP1 are required for this protective effect. Genetic studies have found that a common polymorphic variant in ANGPTL4 results in lower plasma triglyceride levels...
December 8, 2016: ELife
https://www.readbyqxmd.com/read/27913276/association-of-genetic-polymorphisms-of-angiopoietin-like-4-with-severity-of-posttransplant-proteinuria-in-kidney-allograft-recipients
#13
Youngil Chang, Tariq Shah, Jaewook Yang, David I Min
BACKGROUND: Proteinuria is a hallmark of glomerular injury, and persistent proteinuria is associated with graft failure in kidney transplant patients. Recently, it is known that the level of circulating angiopoietin-like 4 (ANGPTL4) is elevated in the patients with human nephrotic syndrome, in which ANGPTL4 is responsible for relieving proteinuria. PURPOSE: The purpose of this study is to determine effects of clinical factors and genetic polymorphism of ANGPTL4 on proteinuria after kidney transplantation...
November 29, 2016: Transplant Immunology
https://www.readbyqxmd.com/read/27875983/liver-transcriptome-response-to-hyperthermic-stress-in-three-distinct-chicken-lines
#14
Xi Lan, John C F Hsieh, Carl J Schmidt, Qing Zhu, Susan J Lamont
BACKGROUND: High ambient temperatures cause stress in poultry, especially for broiler lines, which are genetically selected for rapid muscle growth. RNA-seq technology provides powerful insights into environmental response from a highly metabolic tissue, the liver. We investigated the effects of acute (3 h, 35 °C) and chronic (7d of 35 °C for 7 h/d) heat stress on the liver transcriptome of 3-week-old chicks of a heat-susceptible broiler line, a heat-resistant Fayoumi line, and their advanced intercross line (AIL)...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27865799/oleic-acid-induced-angptl4-enhances-head-and-neck-squamous-cell-carcinoma-anoikis-resistance-and-metastasis-via-up-regulation-of-fibronectin
#15
Chih-Jie Shen, Shih-Hung Chan, Chung-Ta Lee, Wan-Chen Huang, Jhih-Peng Tsai, Ben-Kuen Chen
Obese patients have higher levels of free fatty acids (FFAs) in their plasma and a higher risk of cancer than their non-obese counterparts. However, the mechanisms involved in the regulation of cancer metastasis by FFAs remain unclear. In this study, we found that oleic acid (OA) induced angiopoietin-like 4 (ANGPTL4) protein expression and secretion and conferred anoikis resistance to head and neck squamous cell carcinomas (HNSCCs). The autocrine production of OA-induced ANGPTL4 further promoted HNSCC migration and invasion...
February 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/27834691/zebrafish-model-for-functional-screening-of-flow-responsive-genes
#16
Jovana Serbanovic-Canic, Amalia de Luca, Christina Warboys, Pedro F Ferreira, Le A Luong, Sarah Hsiao, Ismael Gauci, Marwa Mahmoud, Shuang Feng, Celine Souilhol, Neil Bowden, John-Paul Ashton, Henning Walczak, David Firmin, Rob Krams, Justin C Mason, Dorian O Haskard, Spencer Sherwin, Victoria Ridger, Timothy J A Chico, Paul C Evans
OBJECTIVE: Atherosclerosis is initiated at branches and bends of arteries exposed to disturbed blood flow that generates low shear stress. This mechanical environment promotes lesions by inducing endothelial cell (EC) apoptosis and dysfunction via mechanisms that are incompletely understood. Although transcriptome-based studies have identified multiple shear-responsive genes, most of them have an unknown function. To address this, we investigated whether zebrafish embryos can be used for functional screening of mechanosensitive genes that regulate EC apoptosis in mammalian arteries...
January 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27797381/epidermal-growth-factor-induced-angptl4-enhances-anoikis-resistance-and-tumour-metastasis-in-head-and-neck-squamous-cell-carcinoma
#17
Y-H Liao, K-H Chiang, J-M Shieh, C-R Huang, C-J Shen, W-C Huang, B-K Chen
Epidermal growth factor (EGF) is important for cancer cell proliferation, angiogenesis and metastasis in many types of cancer. However, the mechanisms involved in EGF-induced head and neck squamous cell carcinoma (HNSCC) metastasis remain largely unknown. In this study, we reveal that angiopoietin-like 4 (ANGPTL4) plays an important role in the regulation of EGF-induced cancer metastasis. We showed that EGF-induced ANGPTL4 expression promoted anoikis resistance and cancer cell migration and invasion in HNSCC...
October 31, 2016: Oncogene
https://www.readbyqxmd.com/read/27733177/increased-angptl3-4-and-angptl8-betatrophin-expression-levels-in-obesity-and-t2d
#18
Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Betty Chandy, Devarajan Sriraman, Asma Alhubail, Faisal Al-Refaei, Abdulmohsen AlTerki, Jehad Abubaker
BACKGROUND: Hypertriglyceridemia is associated with increased risk for cardiovascular diseases and type 2 diabetes (T2D). Angiopoietin like proteins particularly 3, 4 and recently 8 are well established regulators of plasma triglyceride level through regulating the activity of lipoprotein lipase. Plasma level and association between ANGPTL3, 4 and 8 is not well established in human subjects. This study was designed to establish the level of these proteins in plasma and adipose tissues and investigate the association between ANGPTL8 with ANGPTL3 and 4 in T2D and non-diabetics subjects...
October 13, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27697477/lysophosphatidylcholines-activate-ppar%C3%AE-and-protect-human-skeletal-muscle-cells-from-lipotoxicity
#19
Christian Klingler, Xinjie Zhao, Till Adhikary, Jia Li, Guowang Xu, Hans-Ulrich Häring, Erwin Schleicher, Rainer Lehmann, Cora Weigert
Metabolomics studies of human plasma demonstrate a correlation of lower plasma lysophosphatidylcholines (LPC) concentrations with insulin resistance, obesity, and inflammation. This relationship is not unraveled on a molecular level. Here we investigated the effects of the abundant LPC(16:0) and LPC(18:1) on human skeletal muscle cells differentiated to myotubes. Transcriptome analysis of human myotubes treated with 10μM LPC for 24h revealed enrichment of up-regulated peroxisome proliferator-activated receptor (PPAR) target transcripts, including ANGPTL4, PDK4, PLIN2, and CPT1A...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27612459/adipose-derived-mesenchymal-stem-cells-from-patients-with-atherosclerotic-renovascular-disease-have-increased-dna-damage-and-reduced-angiogenesis-that-can-be-modified-by-hypoxia
#20
Ahmed Saad, Xiang-Yang Zhu, Sandra Herrmann, LaTonya Hickson, Hui Tang, Allan B Dietz, Andre J van Wijnen, Lilach Lerman, Stephen Textor
BACKGROUND: Adipose-derived MSC (AMSCs) possess angiogenic and immunomodulatory properties that may modulate kidney regeneration. Whether these properties are retained in older patients with atherosclerotic vascular disease is poorly understood. Hypoxic conditions are known to modify properties and growth characteristics of AMSCs. We tested the hypothesis that AMSCs from older patients with atherosclerotic renovascular disease (RVD) differ from normal kidney donors, and whether hypoxia changes their functional and molecular properties to promote angiogenesis...
September 9, 2016: Stem Cell Research & Therapy
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