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https://www.readbyqxmd.com/read/28215713/tnf-%C3%AE-decreases-lipoprotein-lipase-activity-in-3t3-l1-adipocytes-by-up-regulation-of-angiopoietin-like-protein-4
#1
Elena Makoveichuk, Evelina Vorrsjö, Thomas Olivecrona, Gunilla Olivecrona
Lipoprotein lipase (LPL) hydrolyzes lipids in plasma lipoproteins so that the fatty acids can be taken up and used by cells. The activity of LPL changes rapidly in response to changes in nutrition, physical activity and other conditions. Angiopoietin-like protein 4 (ANGPTL4) is an important controller of LPL activity. Both LPL and ANGPTL4 are produced and secreted by adipocytes. When the transcription blocker Actinomycin D was added to cultures of 3T3-L1 adipocytes, LPL activity in the medium increased several-fold...
February 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28188788/angiopoietin-like-peptide-4-regulates-insulin-secretion-and-islet-morphology
#2
Hyun-Kyong Kim, Obin Kwon, Kyeong-Han Park, Kyung Jin Lee, Byung-Soo Youn, Seung-Whan Kim, Min-Seon Kim
Insulin secretion from pancreatic islet β-cells is primarily regulated by the blood glucose level, and also modulated by a number of biological factors produced inside the islets or released from remote organs. Previous studies have shown that angiopoietin-like protein 4 (Angptl4) controls glucose and lipid metabolism through its actions in the liver, adipose tissue, and skeletal muscles. In this present study, we investigated the possible role of Angptl4 in the regulation of insulin secretion from pancreatic islets...
February 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28182091/potential-role-of-angptl4-in-the-cross-talk-between-metabolism-and-cancer-through-ppar-signaling-pathway
#3
REVIEW
Laura La Paglia, Angela Listì, Stefano Caruso, Valeria Amodeo, Francesco Passiglia, Viviana Bazan, Daniele Fanale
The angiopoietin-like 4 (ANGPTL4) protein belongs to a superfamily of secreted proteins structurally related to factors modulating angiogenesis known as angiopoietins. At first, ANGPTL4 has been identified as an adipokine exclusively involved in lipid metabolism, because of its prevalent expression in liver and adipose tissue. This protein regulates lipid metabolism by inhibiting lipoprotein lipase (LPL) activity and stimulating lipolysis of white adipose tissue (WAT), resulting in increased levels of plasma triglycerides (TG) and fatty acids...
2017: PPAR Research
https://www.readbyqxmd.com/read/28151839/angiopoietin-like-4-correlates-with-response-to-intravitreal-ranibizumab-injections-in-neovascular-age-related-macular-degeneration
#4
Jong Ho Kim, Jae Pil Shin, In Taek Kim, Dong Ho Park
PURPOSE: To investigate whether the aqueous angiopoietin-like 4 (ANGPTL4) level correlates with clinical features in neovascular age-related macular degeneration (AMD). METHODS: The control and study groups consisted of all consecutive patients who received senile cataract surgery or intravitreal ranibizumab injection for treatment-naïve neovascular AMD, respectively. The AMD group received 3 monthly ranibizumab injections followed by monthly pro re nata for at least 12 months...
February 1, 2017: Retina
https://www.readbyqxmd.com/read/28143927/angptl4-does-not-control-hyperglucagonemia-or-%C3%AE-cell-hyperplasia-following-glucagon-receptor-inhibition
#5
Haruka Okamoto, Katie Cavino, Erqian Na, Elizabeth Krumm, Steven Kim, Panayiotis E Stevis, Joyce Harp, Andrew J Murphy, George D Yancopoulos, Jesper Gromada
Genetic disruption or pharmacologic inhibition of glucagon signaling effectively lowers blood glucose but results in compensatory glucagon hypersecretion involving expansion of pancreatic α-cell mass. Ben-Zvi et al. recently reported that angiopoietin-like protein 4 (Angptl4) links glucagon receptor inhibition to hyperglucagonemia and α-cell proliferation [Ben-Zvi et al. (2015) Proc Natl Acad Sci USA 112:15498-15503]. Angptl4 is a secreted protein and inhibitor of lipoprotein lipase-mediated plasma triglyceride clearance...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28110976/serum-level-of-angptl4-as-a-potential-biomarker-in-renal-cell-carcinoma
#6
Dong Dong, Li Jia, Yunli Zhou, Li Ren, Juan Li, Jun Zhang
OBJECTIVES: This study aimed to determine the serum levels of angiopoietin-like 4 (ANGPTL4) in patients with renal cell carcinoma (RCC) and explore its potential as a biomarker. MATERIALS AND METHODS: Blood samples were taken from 110 patients with RCC, 66 healthy controls, and patients with other solid tumors. Serum ANGPTL4 levels were measured using the enzyme-linked immunosorbent assay, and their correlation with clinical characteristics was further analyzed...
January 19, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28107351/high-concentrations-of-angiopoietin-like-protein-4-detected-in-serum-from-patients-with-rheumatoid-arthritis-can-be-explained-by-non-specific-antibody-reactivity
#7
Elena Makoveichuk, Toralph Ruge, Solveig Nilsson, Anna Södergren, Gunilla Olivecrona
Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride metabolism. Our aim was to study whether the previously reported high levels of ANGPTL4 detected in serum from patients with rheumatoid arthritis (RA) by ELISA was due to any specific molecular form of this protein (oligomers, monomers or fragments). ANGPTL4 levels were first determined in serum from 68 RA patients and 43 age and sex matched control subjects and the mean values differed by a factor of 5.0. Then, ANGPTL4 was analyzed after size exclusion chromatography (SEC) of serum samples...
2017: PloS One
https://www.readbyqxmd.com/read/28067284/oleanolic-acid-ameliorates-high-glucose-induced-endothelial-dysfunction-via-ppar%C3%AE-activation
#8
Zihui Zhang, Manli Jiang, Xinya Xie, Haixia Yang, Xinfeng Wang, Lei Xiao, Nanping Wang
Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a pentacyclic triterpenes widely distributed in food, medicinal plants and nutritional supplements. OA exhibits various pharmacological properties, such as hepatoprotective and anti-tumor effects. In this study, we analyzed the effect of OA on endothelial dysfunction induced by high glucose in human vascular endothelial cells (ECs). Western blotting showed that OA attenuated high glucose-reduced nitric production oxide (NO) as well as Akt-Ser(473) and eNOS-Ser(1177) phosphorylation in cultured human umbilical vein ECs (HUVECs)...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056052/the-glucocorticoid-receptor-regulates-the-angptl4-gene-in-a-ctcf-mediated-chromatin-context-in-human-hepatic-cells
#9
Masafumi Nakamoto, Ko Ishihara, Takehisa Watanabe, Akiyuki Hirosue, Shinjiro Hino, Masanori Shinohara, Hideki Nakayama, Mitsuyoshi Nakao
Glucocorticoid signaling through the glucocorticoid receptor (GR) plays essential roles in the response to stress and in energy metabolism. This hormonal action is integrated to the transcriptional control of GR-target genes in a cell type-specific and condition-dependent manner. In the present study, we found that the GR regulates the angiopoietin-like 4 gene (ANGPTL4) in a CCCTC-binding factor (CTCF)-mediated chromatin context in the human hepatic HepG2 cells. There are at least four CTCF-enriched sites and two GR-binding sites within the ANGPTL4 locus...
2017: PloS One
https://www.readbyqxmd.com/read/28045438/d11-mediated-inhibition-of-protein-kinase-ck2-impairs-hif-1%C3%AE-mediated-signaling-in-human-glioblastoma-cells
#10
Susanne Schaefer, Tina H Svenstrup, Mette Fischer, Barbara Guerra
Compelling evidence indicates that protein kinase CK2 plays an important role in many steps of cancer initiation and progression, therefore, the development of effective and cell-permeable inhibitors targeting this kinase has become an important objective for the treatment of a variety of cancer types including glioblastoma. We have recently identified 1,3-dichloro-6-[(E)-((4-methoxyphenyl)imino)methyl]dibenzo(b,d)furan-2,7-diol (D11) as a potent and selective inhibitor of protein kinase CK2. In this study, we have further characterized this compound and demonstrated that it suppresses CK2 kinase activity by mixed type inhibition (KI 7...
January 1, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28025036/decreased-eicosapentaenoic-acid-levels-in-acne-vulgaris-reveals-the-presence-of-a-proinflammatory-state
#11
İbrahim Aslan, Filiz Özcan, Taner Karaarslan, Ebru Kıraç, Mutay Aslan
This study aimed to determine circulating levels of polyunsaturated fatty acids (PUFAs), secretory phospholipase A2 (sPLA2), lipoprotein lipase (LPL) and measure circulating protein levels of angiopoietin-like protein 3 (ANGPTL3), ANGPTL4, cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in patients with acne vulgaris. Serum from 21 control subjects and 31 acne vulgaris patients were evaluated for levels of arachidonic acid (AA, C20:4n- 6), dihomo-gamma-linolenic acid (DGLA, C20:3n-6), eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3)...
December 23, 2016: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28004575/whole-milk-increases-intestinal-angptl4-expression-and-excretion-of-fatty-acids-through-feces-and-urine
#12
Søren Drud Nielsen, Bashar Amer, Karoline Blaabjerg, Trine K Dalsgaard, Randi Jessen, Bjørn Petrat-Melin, Martin Krøyer Rasmussen, Hanne D Poulsen, Jette F Young
The angiopoietin-like 4 (ANGPLT4) protein is involved in lipid metabolism and is known to inhibit lipoprotein lipase in the bloodstream. We investigated the effect of milk on intestinal ANGPTL4 and the metabolic profile of growing pigs and the effect of free fatty acids (FFAs) on ANGPTL4 in ex vivo and in vitro assays. Feeding pigs whole milk increased intestinal ANGPTL4 mRNA and increased fecal excretion of long-chain FFA compared to the control group fed soybean oil (n = 9). Furthermore, FFAs (C4-C8) induced ANGPTL4 gene expression in porcine intestinal tissue mounted in Ussing chambers and ANGPTL4 protein secretion to both the apical and basolateral sides of intestinal Caco-2 cells on permeable membranes...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27989982/meta-analysis-of-microarray-based-expression-profiles-to-identify-differentially-expressed-genes-in-intracranial-aneurysms
#13
Zhe Xu, Hao Li, Jiangman Song, Bing Han, Zheng Wang, Yong Cao, Shuo Wang, Jizong Zhao
OBJECTIVE: To gain comprehensive insight into the molecular mechanism of formation and rupture of intracranial aneurysms (IAs). METHODS: All publicly accessible microarray-based whole-genome gene expression profiles on IAs were retrieved. The significance analysis of microarrays method was applied to identify differentially expressed genes (DEGs). Functional annotation was performed using gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses...
January 2017: World Neurosurgery
https://www.readbyqxmd.com/read/27984852/biochemical-analysis-of-the-lipoprotein-lipase-truncation-variant-lpl-s447x-reveals-increased-lipoprotein-uptake
#14
Cassandra K Hayne, Michael J Lafferty, Brian J Eglinger, John P Kane, Saskia B Neher
Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipoproteins. Whereas most identified mutations in the LPL gene are deleterious, one mutation, LPL(S447X), causes a gain of function. This mutation truncates two amino acids from LPL's C-terminus. Carriers of LPL(S447X) have decreased VLDL levels and increased HDL levels, a cardioprotective phenotype. LPL(S447X) is used in Alipogene tiparvovec, the gene therapy product for individuals with familial LPL deficiency. It is unclear why LPL(S447X) results in a serum lipid profile more favorable than that of LPL...
January 9, 2017: Biochemistry
https://www.readbyqxmd.com/read/27959692/variants-in-angptl4-and-the-risk-of-coronary-artery-disease
#15
LETTER
Allan D Sniderman, George Thanassoulis
No abstract text is available yet for this article.
8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959691/variants-in-angptl4-and-the-risk-of-coronary-artery-disease
#16
LETTER
Alanna C Morrison, Yi-Ping Fu, Christopher J O'Donnell
No abstract text is available yet for this article.
8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959690/variants-in-angptl4-and-the-risk-of-coronary-artery-disease
#17
LETTER
Frederick E Dewey, Jesper Gromada, Alan R Shuldiner
No abstract text is available yet for this article.
8, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27933182/angiopoietin-like-protein-4-and-cardiovascular-function-in-copd
#18
B Waschki, A M Kirsten, O Holz, T Meyer, R Lichtinghagen, K F Rabe, H Magnussen, T Welte, H Watz, S Janciauskiene
INTRODUCTION: The coexistence of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) is frequent and might be inter-related through inflammation-related processes reflected by specific markers. Here, we studied angiopoietin-like protein 4 (ANGPTL4), an upcoming cardiovascular marker, in stable COPD, and its relationship to cardiovascular function with respect to well-known CVD risk factors. METHODS: In a prospective COPD cohort study, we investigated serum ANGPTL4 levels, vascular status (ankle-brachial index (ABI)) and cardiac function (N-terminal pro-B-type natriuretic peptide (NT-proBNP)) as well as airflow limitation, objectively measured physical activity, the metabolic syndrome, high-sensitive C reactive protein (hs-CRP) and other CVD risk factors at 2 time points...
2016: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/27929370/the-angiopoietin-like-protein-angptl4-catalyzes-unfolding-of-the-hydrolase-domain-in-lipoprotein-lipase-and-the-endothelial-membrane-protein-gpihbp1-counteracts-this-unfolding
#19
Simon Mysling, Kristian Kølby Kristensen, Mikael Larsson, Oleg Kovrov, André Bensadouen, Thomas Jd Jørgensen, Gunilla Olivecrona, Stephen G Young, Michael Ploug
Lipoprotein lipase (LPL) undergoes spontaneous inactivation via global unfolding and this unfolding is prevented by GPIHBP1 (Mysling et al., 2016). We now show: (1) that ANGPTL4 inactivates LPL by catalyzing the unfolding of its hydrolase domain; (2) that binding to GPIHBP1 renders LPL largely refractory to this inhibition; and (3) that both the LU domain and the intrinsically disordered acidic domain of GPIHBP1 are required for this protective effect. Genetic studies have found that a common polymorphic variant in ANGPTL4 results in lower plasma triglyceride levels...
December 8, 2016: ELife
https://www.readbyqxmd.com/read/27913276/association-of-genetic-polymorphisms-of-angiopoietin-like-4-with-severity-of-posttransplant-proteinuria-in-kidney-allograft-recipients
#20
Youngil Chang, Tariq Shah, Jaewook Yang, David I Min
BACKGROUND: Proteinuria is a hallmark of glomerular injury, and persistent proteinuria is associated with graft failure in kidney transplant patients. Recently, it is known that the level of circulating angiopoietin-like 4 (ANGPTL4) is elevated in the patients with human nephrotic syndrome, in which ANGPTL4 is responsible for relieving proteinuria. PURPOSE: The purpose of this study is to determine effects of clinical factors and genetic polymorphism of ANGPTL4 on proteinuria after kidney transplantation...
February 2017: Transplant Immunology
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