keyword
https://read.qxmd.com/read/38546443/sex-differences-in-low-density-lipoprotein-cholesterol-treatment-among-young-israeli-patients-following-premature-acute-coronary-syndrome
#1
JOURNAL ARTICLE
Feras Haskiah, Karam Abdelhai, Ranin Hilu, Abid Khaskia
Introduction: Effective management of dyslipidemias is crucial for reducing morbidity and mortality among patients after acute coronary syndrome (ACS). Sex differences in dyslipidemia management after premature ACS in Israeli patients have not been extensively studied. This study aimed to investigate potential disparities between men and women in managing dyslipidemia, considering current guidelines. Methods: This retrospective cohort study examined patients who were 55 years old or younger and admitted to Meir Medical Center for ACS from January 2018 to February 2019...
March 28, 2024: Metabolic Syndrome and related Disorders
https://read.qxmd.com/read/38545798/prerisk-a-personalized-artificial-intelligence-based-and-statistically-based-stroke-recurrence-predictor-for-recurrent-stroke
#2
JOURNAL ARTICLE
Giorgio Colangelo, Marc Ribo, Estefanía Montiel, Didier Dominguez, Marta Olivé-Gadea, Marian Muchada, Álvaro Garcia-Tornel, Manuel Requena, Jorge Pagola, Jesús Juega, David Rodriguez-Luna, Noelia Rodriguez-Villatoro, Federica Rizzo, Belén Taborda, Carlos A Molina, Marta Rubiera
BACKGROUND: Predicting stroke recurrence for individual patients is difficult, but individualized prediction may improve stroke survivors' engagement in self-care. We developed PRERISK: a statistical and machine learning classifier to predict individual risk of stroke recurrence. METHODS: We analyzed clinical and socioeconomic data from a prospectively collected public health care-based data set of 41 975 patients admitted with stroke diagnosis in 88 public health centers over 6 years (2014-2020) in Catalonia-Spain...
March 28, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38544664/ascending-colon-schwannoma-a-rare-submucosal-tumour
#3
Kugendran Ponniah, Larissa Yong, Abdul Rana, Christopher McDonald
We present a rare case of schwannoma in the ascending colon of a 60-year-old female with dyslipidemia. A series of diagnostic procedures, including colonoscopy and CT colonography, led to the successful robotic-assisted right hemicolectomy. Histological and immunohistochemical analyses confirmed the diagnosis of schwannoma, and the patient achieved a complete recovery post-surgery.
February 2024: Curēus
https://read.qxmd.com/read/38544493/association-of-cardiometabolic-multimorbidity-with-all-cause-and-cardiovascular-disease-mortality-among-chinese-hypertensive-patients
#4
JOURNAL ARTICLE
Luo-Xi Xiao, Zi-Yu Wang, Jiang-Tao Li, Hai-Mei Wang, Yi-Ming Hao, Pan Zhou, Yu-Lin Huang, Qiu-Ju Deng, Yong-Chen Hao, Na Yang, Li-Zhen Han, Zhao Yang, Ping-Ping Jia, Yue Qi, Jing Liu
BACKGROUND: Hypertension usually clusters with multiple comorbidities. However, the association between cardiometabolic multimorbidity (CMM) and mortality in hypertensive patients is unclear. This study aimed to investigate the association between CMM and all-cause and cardiovascular disease (CVD) mortality in Chinese patients with hypertension. METHODS: The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors (CONSIDER), which comprised 5006 participants aged 19-91 years...
February 28, 2024: Journal of Geriatric Cardiology: JGC
https://read.qxmd.com/read/38544492/cardiovascular-risk-factors-in-china
#5
JOURNAL ARTICLE
Sheng-Shou Hu
The Annual Report on Cardiovascular Health and Diseases in China (2022) intricate landscape of cardiovascular health in China. This section dissects cardiovascular risk factors in China which including hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease, metabolic syndrome and air pollution. Hypertension prevalence has steadily increased in China, with efforts to control it facing challenges in achieving optimal rates, especially in rural areas. Interventions like salt substitutes and intensive blood pressure control show promise but need improvement...
February 28, 2024: Journal of Geriatric Cardiology: JGC
https://read.qxmd.com/read/38544373/exploring-the-role-of-oral-microbiome-dysbiosis-in-cardiometabolic-syndrome-and-smoking
#6
REVIEW
Layla I Mohammed, Zain Zaki Zakaria, Fatiha M Benslimane, Maha Al-Asmakh
Oral microbiome research has gained significant interest in recent years due to its potential impact on overall health. Smoking has been identified as a significant modulator of the oral microbiome composition, leading to dysbiosis and possible health consequences. Research has primarily focused on the association between smoking and oral microbiome, as well as smoking's association with cardiometabolic syndrome (CMS). This narrative review presents an overview of the recent findings and current knowledge on the oral microbiome and its role in CMS, including the effects of smoking and ethnicity...
2024: Experimental Lung Research
https://read.qxmd.com/read/38543737/effects-of-hcv-clearance-with-direct-acting-antivirals-daas-on-liver-stiffness-liver-fibrosis-stage-and-metabolic-cellular-parameters
#7
JOURNAL ARTICLE
Joana Ferreira, Manuel Bicho, Fátima Serejo
INTRODUCTION: Chronic hepatitis C (CHC) is a clinical and pathological syndrome with various causes and is characterized by varying degrees of hepatocellular necrosis and inflammation. It is a significant cause of liver transplantation and liver-related death worldwide. The hepatic manifestations of CHC are typically characterized by slowly progressing liver fibrosis, which is a non-specific and often disproportionate response to tissue damage. A large majority of HCV patients have extrahepatic manifestations with varying degrees of severity...
February 27, 2024: Viruses
https://read.qxmd.com/read/38543075/dyslipidemia-a-narrative-review-on-pharmacotherapy
#8
REVIEW
Lucas Lentini Herling de Oliveira, Arthur Cicupira Rodrigues de Assis, Viviane Zorzanelli Rocha Giraldez, Thiago Luis Scudeler, Paulo Rogério Soares
Dyslipidemia plays a fundamental role in the development and progression of atherosclerosis. Current guidelines for treating dyslipidemia focus on low-density lipoprotein-cholesterol (LDL-C). Despite advances in the pharmacotherapy of atherosclerosis, the most successful agents used to treat this disease-statins-remain insufficient in the primary or secondary prevention of acute myocardial infarction. Advancing therapy for hypercholesterolemia with emerging new drugs, either as monotherapy or in combination, is expected to improve cardiovascular outcomes...
February 23, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543024/comprehensive-utilization-technology-of-aronia-melanocarpa
#9
REVIEW
Dongfang Shi, Jing Xu, Li Sheng, Kai Song
Aronia melanocarpa fruit contains a variety of active ingredients, such as phenolic acids, anthocyanins, proanthocyanidins, etc. Relevant in vivo and in vitro studies have concluded that it has beneficial effects in terms of treating dyslipidemia, hypertension, glucose metabolism disorders, etc. This article discusses the nutritional value and food processing of Aronia melanocarpa and reviews the chemical components of Aronia melanocarpa and the pharmacological activities of related substances in order to summarize the chemical characteristics of the fruit and its development prospects...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542495/formulating-treatment-to-cure-alzheimer-s-dementia-approach-2
#10
REVIEW
Jeffrey Fessel
There are two generic approaches to curing any medical condition. The first one treats every patient for all the known possible causes that contribute to pathogenesis; the second one individualizes potentially curative therapy by only identifying in each separate patient the components of pathogenesis that are actually operative and treating those. This article adopts the second approach for formulating a cure for Alzheimer's dementia (AD). The components of AD's pathogenesis are, in alphabetical order, as follows: circadian rhythm disturbances, depression, diabetes and insulin resistance, dyslipidemia, hypertension, inflammation, metabolic syndrome, mitochondrial dysfunction, nutritional deficiencies, TGF-β deficiency, underweight, vascular abnormalities, and Wnt/β-catenin deficiency...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542042/aromatase-inhibitors-and-plasma-lipid-changes-in-postmenopausal-women-with-breast-cancer-a-systematic-review-and-meta-analysis
#11
REVIEW
Bálint Bérczi, Nelli Farkas, Péter Hegyi, Barbara Tóth, Dezső Csupor, Balázs Németh, Anita Lukács, László Márk Czumbel, Beáta Kerémi, István Kiss, Andrea Szabó, Gábor Varga, Gábor Gerber, Zoltán Gyöngyi
Background: Women are typically diagnosed with estrogen receptor-positive breast cancer around the postmenopausal period when declining estrogen levels initiate changes in lipid profiles. Aromatase inhibitors (AI) are used to prevent the progression of cancer; however, a further reduction in estrogen levels may have detrimental effects on lipid levels, which was our working hypothesis. Methods: Our meta-analysis was conducted on the lipid profiles of postmenopausal breast cancer patients at baseline and at different treatment time points...
March 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541026/a-cross-sectional-study-on-the-role-of-a-lab-test-screening-program-in-defining-cardiovascular-disease-risk-prevalence
#12
JOURNAL ARTICLE
Antoanela Curici, Mihaela Roxana Popescu, Viviana Adriana Pîrvuleț, Gabriela-Irina Marinescu, Ana Corina Ionescu
Recent epidemiologic studies carried out in Romania confirmed an ascending trend for cardiovascular disease (CVD) risk factor prevalence such as diabetes mellitus (DM), obesity and dyslipidemia. The aim of this study is to describe the CVD risk factor profile and preventative behavior in a representative sample of the general adult population of an Eastern Romanian urban area. More than 70% of the studied population had a body mass index (BMI) above the normal range for their age, with 36.7% of the subjects residing in obesity and severe obesity clusters...
March 4, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540979/the-interplay-between-dyslipidemia-and-neighboring-developments-in-coronary-artery-disease-progression-a-personalized-approach
#13
JOURNAL ARTICLE
Tomasz Urbanowicz, Krzysztof Skotak, Anna Olasińska-Wiśniewska, Krzysztof J Filipiak, Jakub Bratkowski, Beata Krasińska, Zbigniew Krasiński, Andrzej Tykarski, Marek Jemielity
(1) Background: Estimates suggest that up to 10% of global annual cardiovascular deaths could be related to environmental factors. Not only air pollution components, but also noise exposure and climate changes, are highlighted as nontraditional causes of cardiovascular morbidity. The aim of this study was to identify possible urbanization risk factors for the progression of coronary artery disease in a group of patients with chronic coronary syndrome. (2) Method: There were 77 patients (50 (65%) males and 27 (35%) females) with a median age of 70 (60-74) years who underwent repetitive angiography due to chronic coronary syndrome between 2018 and 2022...
February 23, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540623/prevalence-and-risk-factors-for-renal-insufficiency-among-adults-living-with-hiv-in-tanzania-results-from-a-cross-sectional-study-in-2020-2021
#14
JOURNAL ARTICLE
Theresia A Ottaru, Gideon P Kwesigabo, Zeeshan Butt, Matthew Caputo, Pilly Chillo, Hellen Siril, Lisa R Hirschhorn, Claudia Hawkins
With improved survival, adults living with HIV (ALHIV) are increasingly likely to experience age-related and HIV-related comorbidities, including renal insufficiency. Other risk factors for renal insufficiency (high blood pressure (BP), obesity, diabetes, and dyslipidemia) are also growing more common among ALHIV. To determine the prevalence of renal insufficiency (defined as an eGFR < 60 mL/min/1.73 m2 ) and factors associated with reduced eGFR, we conducted a cross-sectional study at six HIV clinics in Dar-es-Salaam, Tanzania...
March 14, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38540442/the-health-history-of-first-degree-relatives-dyslipidemia-can-affect-preferences-and-intentions-following-the-return-of-genomic-results-for-monogenic-familial-hypercholesterolemia
#15
JOURNAL ARTICLE
Tomoharu Tokutomi, Akiko Yoshida, Akimune Fukushima, Kayono Yamamoto, Yasushi Ishigaki, Hiroshi Kawame, Nobuo Fuse, Fuji Nagami, Yoichi Suzuki, Mika Sakurai-Yageta, Akira Uruno, Kichiya Suzuki, Kozo Tanno, Hideki Ohmomo, Atsushi Shimizu, Masayuki Yamamoto, Makoto Sasaki
Genetic testing is key in modern healthcare, particularly for monogenic disorders such as familial hypercholesterolemia. This Tohoku Medical Megabank Project study explored the impact of first-degree relatives' dyslipidemia history on individual responses to familial hypercholesterolemia genomic results. Involving 214 participants and using Japan's 3.5KJPN genome reference panel, the study assessed preferences and intentions regarding familial hypercholesterolemia genetic testing results. The data revealed a significant inclination among participants with a family history of dyslipidemia to share their genetic test results, with more than 80% of participants intending to share positive results with their partners and children and 98...
March 21, 2024: Genes
https://read.qxmd.com/read/38540284/connections-between-cognitive-impairment-and-atrial-fibrillation-in-patients-with-diabetes-mellitus-type-2
#16
JOURNAL ARTICLE
Marius Militaru, Daniel Florin Lighezan, Cristina Tudoran, Anda Gabriela Militaru
(1) Background: Cognitive decline (CD), considered a precursory state of dementia, is frequently encountered in patients with diabetes mellitus type 2 (DM-2) and might even have a higher prevalence in those with associated atrial fibrillation (AF). In this study, we aimed to research if the association of DM-2 and AF favors a precocious onset of CD. (2) Methods: This study was conducted on 160 patients, featuring 50 with DM-2, 54 with DM-2 and AF, and 56 subjects without DM-2 and AF, all evaluated clinically and with five neuropsychiatric scales...
March 17, 2024: Biomedicines
https://read.qxmd.com/read/38540230/associations-of-the-cyp7a1-gene-polymorphisms-located-in-the-promoter-and-enhancer-regions-with-the-risk-of-acute-coronary-syndrome-plasma-cholesterol-and-the-incidence-of-diabetes
#17
JOURNAL ARTICLE
Gilberto Vargas-Alarcón, Óscar Pérez-Méndez, Rosalinda Posadas-Sánchez, Héctor González-Pacheco, María Luna-Luna, Galileo Escobedo, José Manuel Fragoso
Cholesterol-7-alpha hydroxylase (CYP7A1) is a key enzyme in the synthesis of bile salts, and its activity can contribute to determining cholesterol levels and, consequently, the risk of developing coronary atherosclerotic disease. We evaluated whether seven (rs3808607 G/T , rs9297994 G/A , rs10504255 A/G , rs8192870 G/T , rs2081687 C/T , rs1457043 C/T, and rs10107182 C/T) polymorphisms located in the promoter and enhancer regions of the CYP7A1 gene, which have not been sufficiently explored, are candidates of risk markers of acute coronary syndrome (ACS) in the Mexican population...
March 9, 2024: Biomedicines
https://read.qxmd.com/read/38539854/the-efficacy-and-safety-of-gf101-and-its-antioxidant-effect-on-in-vitro-fertilization-outcomes-a-double-blind-non-inferiority-randomized-controlled-trial-with-coenzyme-q10
#18
JOURNAL ARTICLE
So Yeon Shin, Hye Kyung Yoon, Jee Hyun Kim, Ji Hyang Kim, Chan Park, Dong Hee Choi, Young Dong Yu, Ji Eun Shin, Hwang Kwon
(1) Background: Oxidative stress adversely affects fertility by impairing oocyte fertilization potential, primarily due to meiotic segregation errors and cohesion loss. Superoxide dismutase (SOD) and Coenzyme Q10 (CoQ10) are prominent antioxidants known to mitigate oxidative damage. (2) Methods: This study recruited 86 patients undergoing in vitro fertilization (IVF) at a single center for a 12-week, randomized, double-blind, active-comparator-controlled trial. Participants were allocated into two groups: one receiving CoQ10 as an antioxidant (the CoQ10 group) and the other receiving GF Bacillus antioxidative enzyme SOD (the GF101 group)...
March 6, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38538342/the-significance-of-lipoproteins-in-the-development-of-obesity
#19
REVIEW
Alexander Blagov, Konstantin Rufanov, Khokhlova Irina, Vasily Sukhorukov, Andrey Goncharov, Elizaveta Pleshko, Alexander Orekhov
Disruption of lipoprotein metabolism plays an important role in the development of several cardiovascular, inflammatory, and metabolic diseases. This review examines the importance of different types of lipoproteins and the role they play in the development of dyslipidemia in obesity. The causes and consequences associated with the disruption of lipid metabolism and its significance in the pathogenesis of obesity are considered. The relationship between such pathological processes, which occur alongside obesity as dyslipidemia and inflammation, is determined...
March 18, 2024: Frontiers in Bioscience (Scholar Edition)
https://read.qxmd.com/read/38538336/transitional-medicine-of-intractable-primary-dyslipidemias-in-japan
#20
JOURNAL ARTICLE
Masatsune Ogura, Sachiko Okazaki, Hiroaki Okazaki, Hayato Tada, Kazushige Dobashi, Kimitoshi Nakamura, Keiji Matsunaga, Takashi Miida, Tetsuo Minamino, Shinji Yokoyama, Mariko Harada-Shiba
Transitional medicine refers to the seamless continuity of medical care for patients with childhood-onset diseases as they grow into adulthood. The transition of care must be seamless in medical treatment as the patients grow and in other medical aids such as subsidies for medical expenses in the health care system. Inappropriate transitional care, either medical or social, directly causes poorer prognosis for many early-onset diseases, including primary dyslipidemia caused by genetic abnormalities. Many primary dyslipidemias are designated as intractable diseases in the Japanese health care system for specific medical aids, as having no curative treatment and requiring enormous treatment costs for lipid management and prevention of complications...
March 26, 2024: Journal of Atherosclerosis and Thrombosis
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