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https://www.readbyqxmd.com/read/28530031/celecoxib-for-osteoarthritis
#1
REVIEW
Livia Puljak, Ana Marin, Davorka Vrdoljak, Filipa Markotic, Ana Utrobicic, Peter Tugwell
BACKGROUND: Osteoarthritis (OA) is the most common form of arthritis and is caused by degeneration of the joint cartilage and growth of new bone, cartilage and connective tissue. It is often associated with major disability and impaired quality of life. There is currently no consensus on the best treatment to improve OA symptoms. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID). OBJECTIVES: To assess the clinical benefits (pain, function, quality of life) and safety (withdrawals due to adverse effects, serious adverse effects, overall discontinuation rates) of celecoxib in osteoarthritis (OA)...
May 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28529106/engineered-cartilage-regeneration-from-adipose-tissue-derived-mesenchymal-stem-cells-a-morphomolecular-study-on-osteoblast-chondrocyte-and-apoptosis-evaluation
#2
Marta Anna Szychlinska, Paola Castrogiovanni, Houda Nsir, Michelino Di Rosa, Claudia Guglielmino, Rosalba Parenti, Giovanna Calabrese, Elisabetta Pricoco, Lucia Salvatorelli, Gaetano Magro, Rosa Imbesi, Ali Mobasheri, Giuseppe Musumeci
The poor self-repair capacity of cartilage tissue in degenerative conditions, such as osteoarthritis (OA), has prompted the development of a variety of therapeutic approaches, such as cellular therapies and tissue engineering based on the use of mesenchymal stem cells (MSCs). The aim of this study is to demonstrate, for the first time, that the chondrocytes differentiated from rat adipose tissue derived-MSCs (AMSCs), are able to constitute a morphologically and biochemically healthy hyaline cartilage after 6 weeks of culture on a Collagen Cell Carrier (CCC) scaffold...
May 18, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28528759/replicate-effects-and-test-retest-reliability-of-quantitative-sensory-threshold-testing-in-dogs-with-and-without-chronic-pain
#3
David Knazovicky, Erika S Helgeson, Beth Case, Andrea Thomson, Margaret E Gruen, William Maixner, B Duncan X Lascelles
OBJECTIVE: To evaluate replicate effects and test-retest reliability of mechanical and thermal quantitative sensory testing (QST) in normal dogs and dogs with osteoarthritis (OA)-associated pain. STUDY DESIGN: A prospective clinical study. ANIMALS: A total of 54 client owned dogs (OA, n=31; controls, n=23). METHODS: Mechanical [electronic von Frey (EVF) and blunt pressure] and thermal (hot and cold) sensory thresholds were obtained in dogs with OA-associated pain and control dogs at two visits, 7 days apart, to assess test-retest reliability...
January 10, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28528004/potential-contributions-of-skeletal-muscle-contractile-dysfunction-to-altered-biomechanics-in-obesity
#4
REVIEW
Lance M Bollinger
Obesity alters whole body kinematics and joint kinetics during activities of daily living which are thought to contribute to increased risk of musculoskeletal injury, development of lower extremity joint osteoarthritis (OA), and physical disability. To date, it has widely been accepted that excess adipose tissue mass is the major driver of biomechanical alterations in obesity. However, it is well established that obesity is a systemic disease affecting numerous, if not all, organ systems of the body. Indeed, obesity elicits numerous adaptations within skeletal muscle, including alterations in muscle structure (ex...
May 13, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28526995/two-cycles-of-plasma-rich-in-growth-factors-prgf-endoret-intra-articular-injections-improve-stiffness-and-activities-of-daily-living-but-not-pain-compared-to-one-cycle-on-patients-with-symptomatic-knee-osteoarthritis
#5
Víctor Vaquerizo, Sabino Padilla, José Javier Aguirre, Leire Begoña, Gorka Orive, Eduardo Anitua
PURPOSE: To assess the clinical efficacy and safety of a treatment based on one cycle versus two cycles of intra-articular injections of plasma rich in growth factors (PRGF-Endoret) on patients with knee osteoarthritis (OA). METHODS: Ninety patients with knee OA were included and evaluated. A total of 48 patients received one cycle (OC group) (3 injections on a weekly basis), while 42 patients received two cycles of PRGF-Endoret (TC group) spaced 6 months between them...
May 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28526923/focal-articular-prosthetic-resurfacing-for-the-treatment-of-full-thickness-articular-cartilage-defects-in-the-knee-12-year-follow-up-of-two-cases-and-review-of-the-literature
#6
C Becher, E B Cantiller
INTRODUCTION: The rationale of focal articular prosthetic resurfacing used as a primary arthroplasty procedure in the treatment of articular cartilage defects is still under debate. Conflicting reports raise concern about high rates of re-operations and continued development of osteoarthritis, while others have reported good outcomes. The goal of this paper is to present the long-term results of two patients with a 12-year follow-up and to report the results of a literature review. MATERIALS AND METHODS: Two patients (male, 70 years; female 63 years) with a follow-up of 12 years were reviewed...
May 19, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28526072/differences-in-serum-and-synovial-cd4-t-cells-and-cytokine-profiles-to-stratify-patients-with-inflammatory-osteoarthritis-and-rheumatoid-arthritis
#7
Alessandra Penatti, Federica Facciotti, Roberta De Matteis, Paola Larghi, Moira Paroni, Antonella Murgo, Orazio De Lucia, Massimiliano Pagani, Luca Pierannunzii, Marcello Truzzi, Andreea Ioan-Facsinay, Sergio Abrignani, Jens Geginat, Pier Luigi Meroni
BACKGROUND: The aim was to investigate CD4(+)T-cell subsets, immune cells and their cytokine profiles in blood and synovial compartments in rheumatoid arthritis (RA) and inflammatory osteoarthritis (OA) to define specific immune signatures. METHODS: Peripheral blood, synovial fluid (SF) and synovial membranes (SM) of RA and OA patients were analyzed. CD4(+)T-cell subset frequencies were determined by flow cytometry, and cytokine concentrations in serum and SF were measured by ELISA...
May 19, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28525958/necessity-of-immobilizing-the-metacarpophalangeal-joint-in-carpometacarpal-osteoarthritis-short-term-effect
#8
Raquel Cantero-Téllez, Kristin Valdes, Deborah A Schwartz, Ivan Medina-Porqueres, Jean Christophe Arias, Jorge H Villafañe
BACKGROUND: Conservative treatment for carpometacarpal (CMC) joint osteoarthritis (OA) may include orthotic fabrication to decrease pain. Different types of orthoses have been used as conservative interventions to improve symptoms, but there are no guidelines specifying if inclusion of the thumb metacarpophalangeal (MCP) in an orthosis is required in the treatment of thumb CMC joint OA. The main objective of this study is to determine the effectiveness of 2 different thumb CMC joint orthotic designs on pain reduction and improved hand function: one design immobilizes both the MCP joint and the CMC joint and the other design immobilizes only the CMC joint...
May 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28525629/the-association-of-perceived-memory-loss-with-osteoarthritis-and-related-joint-pain-in-a-large-appalachian-population
#9
Kim E Innes, Usha Sambamoorthi
Objective. : Previous studies have documented memory impairment in several chronic pain syndromes. However, the potential link between memory loss and osteoarthritis (OA), the second most common cause of chronic pain, remains little explored. In this cross-sectional study, we examine the association of perceived memory loss to OA and assess the potential mediating influence of sleep and mood disturbance in a large Appalachian population. Design.:  Cross-sectional...
May 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28525322/a-systemic-review-of-existing-serological-possibilities-to-diagnose-canine-osteoarthritis-with-a-particular-focus-on-extracellular-matrix-proteoglycans-and-protein
#10
M Shahid, G Manchi, P Slunsky, O Naseer, A Fatima, B Leo, J Raila
Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter α-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases...
March 28, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28524271/histological-characteristics-of-knee-menisci-in-patients-with-osteoarthritis
#11
D McDaniel, E Tilton, K Dominick, K Flory, T Ernest, J C Johnson, D C Main, P Kondrashov
INTRODUCTION: Existing data indicate knee menisci in patients with osteoarthritis (OA) show tearing, maceration, and fragmentation, but little is known about the change in histological structure. The aim of this study was to evaluate change in the menisci histological structure in patients with clinically diagnosed knee OA. MATERIALS AND METHODS: Fourteen patients undergoing surgical treatment of knee OA (OA group) and 14 cadaveric knees (control group) were assessed...
May 19, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28521989/synthesis-of-strontium-chondroitin-sulfate-and-the-evaluation-of-its-capability-to-attenuate-osteoarthritis
#12
F B Ma, N Liu, N Hu, C Y Wen, B Tang
Osteoarthritis (OA) is the most prevalent musculoskeletal disorder and the leading cause of joint disability in elderly patients. In this study, we fabricated strontium chondroitin sulfate (SrCS), a new polysaccharide-metal ion complex that is the combination of chondroitin sulfate and strontium, which are two widely adopted chemicals in OA clinical management. The structural, chemical compositions and morphology of as-fabricated SrCS were systematically investigated. Cell proliferation test, RT-PCR and preliminary animal studies were conducted to evaluate the clinical potential of SrCS on OA treatment...
August 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28520497/lncrna-pvt1-regulates-chondrocyte-apoptosis-in-osteoarthritis-by-acting-as-a-sponge-for-mir-488-3p
#13
Yufei Li, Shuhua Li, Yatong Luo, Yong Liu, Nanhui Yu
Long noncoding RNAs (lncRNAs) have been known to be involved in multiple diverse diseases, including osteoarthritis (OA). The present study aims at exploring the biological role of lncRNA plasmacytoma variant translocation 1 (PVT1) in OA and the underlying mechanism. Results showed that the expression of PVT1 was upregulated in OA chondrocytes compared with normal chondrocytes, silencing PVT1 inhibited the apoptosis of OA chondrocytes, and overexpression of PVT1 promoted the apoptosis of normal chondrocytes...
May 18, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28520463/a-preclinical-assessment-of-early-continuous-passive-motion-and-treadmill-therapeutic-exercises-for-generating-chondroprotective-effects-after-anterior-cruciate-ligament-rupture
#14
Nai-Jen Chang, Kuan-Wei Lee, Chih-Jou Chu, Ming-You Shie, Pei-Hsi Chou, Chih-Chan Lin, Peir-In Liang
BACKGROUND: Anterior cruciate ligament (ACL) injury is a well-known risk factor for the development of posttraumatic osteoarthritis (PTOA). However, whether using continuous passive motion (CPM) with or without additional treadmill exercise (TRE) in early ACL injury might provide chondroprotective effects and further decrease the risk of PTOA has yet to be determined. HYPOTHESIS: CPM may offer an enhanced chondroprotective effect, but TRE may attenuate that effect due to the mechanical stress on the joint and inflammatory cytokines in the joint...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28520086/activated-fgfr3-prevents-subchondral-bone-sclerosis-during-the-development-of-osteoarthritis-in-transgenic-mice-with-achondroplasia
#15
Toshiaki Okura, Masaki Matsushita, Kenichi Mishima, Ryusaku Esaki, Taisuke Seki, Naoki Ishiguro, Hiroshi Kitoh
The purpose of this study is to investigate the morphometric changes of the subchondral bone during the development of osteoarthritis (OA) in transgenic mice with achondroplasia (Fgfr3(ach) ) carrying a heterozygous gain-of-function mutation in Fgfr3. Two OA models (spontaneously developed with age: the aging model, and surgically induced by destabilization of the medial meniscus: the DMM model) were established. Articular cartilage, epiphysis and metaphysis of the knee joint were histologically and morphometrically compared between wild-type mice and Fgfr3(ach) mice in both OA models...
May 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28518064/an-experimental-and-finite-element-protocol-to-investigate-the-transport-of-neutral-and-charged-solutes-across-articular-cartilage
#16
Vahid Arbabi, Behdad Pouran, Amir A Zadpoor, Harrie Weinans
Osteoarthritis (OA) is a debilitating disease that is associated with degeneration of articular cartilage and subchondral bone. Degeneration of articular cartilage impairs its load-bearing function substantially as it experiences tremendous chemical degradation, i.e. proteoglycan loss and collagen fibril disruption. One promising way to investigate chemical damage mechanisms during OA is to expose the cartilage specimens to an external solute and monitor the diffusion of the molecules. The degree of cartilage damage (i...
April 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28516738/intrinsic-fluorescence-and-mechanical-testing-of-articular-cartilage-in-human-patients-with-osteoarthritis
#17
Juan Pablo Padilla-Martinez, William Lewis, Antonio Ortega-Martinez, Walfre Franco
The degeneration of articular cartilage is the main cause of osteoarthritis (OA), a common cause of disability among elderly patients. The aim of this study is to understand the correlation between intrinsic fluorescence of articular cartilage and its biomechanical properties in patients with osteoarthritis. Cylindrical samples of articular cartilage 6 mm in diameter were extracted via biopsy punch from the femoral condyles of 6 patients with advanced OA undergoing knee replacement surgery. The mechanical stiffness and fluorescence of each cartilage plug were measured by indentation test and spectrofluorometry...
May 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28516048/image-interpolation-improves-the-zonal-analysis-of-cartilage-t2-relaxation-in-mri
#18
Farid Badar, Yang Xia
BACKGROUND: This project aimed to investigate the improvement in the detection of osteoarthritis (OA) in cartilage by the interpolation of T2 images, in the situation when the native MRI resolution is insufficient to resolve the depth-dependent T2 characteristics in articular cartilage (AC). METHODS: Eighteen intact canine knee joints that were healthy or had mild (contralateral) or severe OA were T2-imaged in a 7T/20 cm MRI system at 200 µm/pixel resolution (macro-MRI)...
April 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28515465/gender-specific-differential-expression-of-exosomal-mirna-in-synovial-fluid-of-patients-with-osteoarthritis
#19
Ravindra Kolhe, Monte Hunter, Siyang Liu, Ravirajsinh N Jadeja, Chetan Pundkar, Ashis K Mondal, Bharati Mendhe, Michelle Drewry, Mumtaz V Rojiani, Yutao Liu, Carlos M Isales, Robert E Guldberg, Mark W Hamrick, Sadanand Fulzele
The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeutic approaches are limited to preventing progression of the disease. Recent studies have shown that exosomes play a vital role in cell-to-cell communication, and pathogenesis of many age-related diseases. Molecular profiling of synovial fluid derived exosomal miRNAs may increase our understanding of OA progression and may lead to the discovery of novel biomarkers and therapeutic targets. In this article we report the first characterization of exosomes miRNAs from human synovial fluid...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514935/mesenchymal-stem-cell-based-cartilage-regeneration-approach-and-cell-senescence-can-we-manipulate-cell-aging-and-function
#20
Marta Anna Szychlinska, Martin James Stoddart, Ugo D'Amora, Luigi Ambrosio, Mauro Alini, Giuseppe Musumeci
Aging is the most prominent risk factor triggering several degenerative diseases, such as Osteoarthritis (OA). Due to its poor self-healing capacity, once injured cartilage needs to be re-established. This process mighmight be approached bythrough resorting to cell-based therapies and/or tissue engineering. Human mesenchymal stem cells (hMSC) represent a promising approach due to their chondrogenic differentiation potential. Presently, in vitro chondrogenic differentiation of MSCs is limited by two main reasons: Aging aging of MSCs, which determines the loss of cell proliferative and differentiationed capacity and MSC-derived chondrocyte hypertrophic differentiation, which limits the use of these cells in cartilage tissue regeneration approach...
May 17, 2017: Tissue Engineering. Part B, Reviews
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