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https://www.readbyqxmd.com/read/28742830/regulatory-effects-of-zinc-on-cadmium-induced-cytotoxicity-in-chronic-inflammation
#1
Paola Bonaventura, Aline Lamboux, Francis Albarède, Pierre Miossec
OBJECTIVES: Zinc (Zn) has major effects on immune system activation while Cadmium (Cd) has anti-inflammatory and anti-proliferative effects in several chronic inflammatory contexts. The aim of this work was to investigate by which mechanisms Zn could compete with Cd and eventually counteract its deleterious effects. Rheumatoid arthritis (RA) synoviocytes exposed to cytokines were used as a model of chronic inflammation; osteoarthritis (OA) synoviocytes were used as control. METHODS: Cell/medium fractionation constants were analyzed for different metals by inductively-coupled-plasma mass-spectrometry by comparison to the 70Zn spike...
2017: PloS One
https://www.readbyqxmd.com/read/28741742/dental-and-skeletal-maturation-in-female-adolescents-with-temporomandibular-joint-osteoarthritis
#2
Jeong-Hyun Kang, Ill-Hyung Yang, Hong-Keun Hyun, Jeong-Yun Lee
BACKGROUND: Occurrence of temporomandibular disorders (TMDs) and temporomandibular joint (TMJ) osteoarthritis (OA) during adolescence may have interactions with mandibular and dental development. OBJECTIVE: To investigate relationships between occurrence of TMD and TMJ OA and extents of dental and skeletal development in juvenile female patients. METHOD: In total, 95 female adolescents (age range, 11-15 years) were selected. Among them, 15 subjects (control) had no signs of TMD, 39 TMD patients did not have OA (TMDnoOA), 17 TMD patients were at initial stage of TMJ OA (TMJOA), and 27 patients showed progressive stage of TMJ OA (TMJOA)...
July 25, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28739300/the-critical-shoulder-angle-is-associated-with-osteoarthritis-in-the-shoulder-but-not-rotator-cuff-tears-a-retrospective-case-control-study
#3
Arnar O Bjarnison, Thomas J Sørensen, Thomas Kallemose, Kristoffer W Barfod
BACKGROUND: In 2013 Moor et al introduced the concept of the critical shoulder angle (CSA) and suggested that an abnormal CSA was a leading factor in development of rotator cuff tear (RCT) and osteoarthritis (OA) of the shoulder. This study assessed whether the CSA was associated with RCT and OA and tested the inter- and intrarater reliability of the CSA when measuring RCT and OA. MATERIALS AND METHODS: The study was performed as a retrospective case-control study...
July 21, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28739110/transforming-growth-factor-beta1-being-considered-a-novel-biomarker-in-knee-osteoarthritis
#4
Jianwei He, Weiwei Cao, Inayat Azeem, Qiang Zhao, Zengwu Shao
BACKGROUND: Associations between Transforming Growth Factor beta-1 (TGF-β1), Platelet-derived growth factor BB (PDGF-BB) and C-terminal telopeptide of type I collagen (CTX-1) with pathogenesis of osteoarthritis (OA) have already been established. Therefore, TGF-β1, PDGF-BB and CTX-1 could be used as the potential biomarkers for the diagnosis of this disease. METHODS: 160 knee OA cases and 80 healthy controls were chosen. Serum concentrations of TGF-β1, PDGF-BB and CTX-1 were tested twice on the same samples using Enzyme-Linked Immunosorbent Assay...
July 21, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28738541/research-progress-on-osteoarthritis-treatment-mechanisms
#5
REVIEW
Yun-Yao Gu, Jian Chen, Zhu-Long Meng, Wan-Yu Ge, Yang-Yang Bian, Shao-Wen Cheng, Chen-Kun Xing, Jiang-Ling Yao, Jian Fu, Lei Peng
Osteoarthritis is a common disease and is frequently encountered in the older population; the incidence rises sharply with age. It is estimated that more than 360 million people suffer from OA. However, the pathogenesis of osteoarthritis remains unclear, and we cannot effectively prevent the progression of OA. The aim of this review was to explore the molecular markers and signaling pathways that induce chondrocyte apoptosis in OA. We searched, using the key words osteoarthritis, chondrocyte apoptosis, autophagy, endoplasmic reticulum stress, molecular targets, and biomarkers, in PubMed, Web of Science, and Google Scholar from 1994 to 2017...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738428/association-between-patient-history-and-physical-examination-and-osteoarthritis-after-ankle-sprain
#6
John M van Ochten, Anja D de Vries, Nienke van Putte, Edwin H G Oei, Patrick J E Bindels, Sita M A Bierma-Zeinstra, Marienke van Middelkoop
Structural abnormalities on MRI are frequent after an ankle sprain. To determine the association between patient history, physical examination and early osteoarthritis (OA) in patients after a previous ankle sprain, 98 patients with persistent complaints were selected from a cross-sectional study. Patient history taking and physical examination were applied and MRI was taken. Univariate and multivariable analyses were used to test possible associations. Signs of OA (cartilage loss, osteophytes and bone marrow edema) were seen in the talocrural joint (TCJ) in 40% and the talonavicular joint (TNJ) in 49%...
July 24, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28738079/comparison-between-intra-articular-ozone-and-placebo-in-the-treatment-of-knee-osteoarthritis-a-randomized-double-blinded-placebo-controlled-study
#7
Carlos César Lopes de Jesus, Fânia Cristina Dos Santos, Luciana Maria Oliveira Bueno de Jesus, Iara Monteiro, Maria Sonia Sousa Castro Sant'Ana, Virginia Fernandes Moça Trevisani
OBJECTIVE: The aim of the trial was to determine the effectiveness of oxygen-ozone injections on knee osteoarthritis concerning pain reduction, joint functional improvement, and quality of life. METHODS: In this randomized, double-blinded, placebo controlled clinical trial, 98 patients with symptomatic knee osteoarthritis (OA) were randomized into two groups receiving intra-articular 20 μg/ml of ozone (OZ) or placebo (PBO) for 8 weeks. The efficacy outcomes for knee OA were the Visual Analogue Scale (VAS), Lequesne Index, Timed Up and Go Test (TUG Test), SF-36, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and Geriatric Pain Measure (GPM)...
2017: PloS One
https://www.readbyqxmd.com/read/28737953/metabolic-factors-and-oxidative-stress-in-osteoarthritis-a-case-control-study
#8
Kaspar Tootsi, Aare Märtson, Jaak Kals, Kaido Paapstel, Mihkel Zilmer
Previous studies suggest that metabolic disturbances might be involved in the development of osteoarthritis (OA). Associations have been found between the individual components of metabolic syndrome (MetS) and OA. MetS has been associated with increased oxidative stress (OxS). The study aimed to clarify the role of MetS components in OA and to evaluate the levels of OxS in OA patients and in age-matched controls. Fifty-five patients with end-stage OA (age 63 ± 7 years) prior to hip or knee joint replacement surgery and 55 age-, gender- and body mass index matched controls (61 ± 8 years) were enrolled in the study...
July 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28735840/critical-shoulder-angle-is-associated-with-full-thickness-rotator-cuff-tears-in-patients-with-glenohumeral-osteoarthritis
#9
Matthew T Mantell, Ryan Nelson, Jeremiah T Lowe, Donald P Endrizzi, Andrew Jawa
BACKGROUND: Higher critical shoulder angle (CSA) is correlated with rotator cuff tears (RCTs), whereas lower CSA is associated with glenohumeral osteoarthritis (OA). Our goal was to investigate whether patients with concurrent glenohumeral OA and full-thickness RCTs demonstrate a higher CSA than patients with OA alone. METHODS: Using a 2-surgeon shoulder arthroplasty registry, we identified 31 patients with glenohumeral OA and full-thickness RCTs confirmed by plain radiography and magnetic resonance imaging, respectively...
July 20, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28735021/wisp1-ccn4-aggravates-cartilage-degeneration-in-experimental-osteoarthritis
#10
Martijn H van den Bosch, Arjen B Blom, Vardit Kram, Azusa Maeda, Sheena Sikka, Yankel Gabet, Tina M Kilts, Wim B van den Berg, Peter L van Lent, Peter M van der Kraan, Marian F Young
OBJECTIVE: Increased Wisp1 expression was previously reported in experimental and human osteoarthritis. Moreover, adenoviral overexpression of Wisp1 in naïve mouse knee joints resulted in early OA-like cartilage lesions. Here, we determined how the matricellular protein WISP1 is involved in the pathology that occurs in the complex osteoarthritic environment with aging and experimental osteoarthritis in wild type and Wisp1(-/-) mice. METHODS: Wild type and Wisp1(-/-) mice were aged or experimental osteoarthritis was induced with intraarticular collagenase injection, destabilization of the medial meniscus or anterior cruciate ligament transection...
July 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28734667/characterization-of-cartilage-defects-detected-by-mri-in-kellgren-lawrence-grade-0-or-1-knees
#11
Kenji Taguchi, Ko Chiba, Narihiro Okazaki, Yasuo Kido, Takashi Miyamoto, Akihiko Yonekura, Masato Tomita, Masataka Uetani, Makoto Osaki
INTRODUCTION: Osteoarthritis of the knee is generally evaluated by plain X-rays, which are incapable of detecting small cartilage damage. There are some patients who have small cartilage defects on MRI with no abnormal findings on plain X-rays. In this study, the prevalence and regional characteristics of cartilage defects detected by MRI were studied in cases with normal X-ray findings (Kellgren-Lawrence grade 0 and 1). Relationships between the cartilage defects and OA risk factors such as obesity and leg alignment were also investigated...
July 19, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28732855/effects-of-thermosensitive-chitosan-gelatin-based-hydrogel-containing-glutathione-on-cisd2-deficient-chondrocytes-under-oxidative-stress
#12
Yung-Hsin Cheng, Eddy Chavez, Kun-Ling Tsai, Kai-Chiang Yang, Wei-Ting Kuo, Yi-Ping Yang, Shih-Hwa Chiou, Feng-Huei Lin
Aging is considered as a primary risk factor in the development of osteoarthritis (OA) which associated with mitochondrial dysfunction and oxidative stress. CDGSH iron sulfur domain 2 (Cisd2) deficiency causes mitochondrial dysfunction and drive premature aging. In the present study, thermosensitive chitosan-gelatin based hydrogel containing glutathione was developed as injectable drug delivery system for administration by minimal invasive surgery for the treatment of OA. Cisd2 deficiency (Cisd2(-/-)) mouse induced pluripotent stem cells-derived chondrocytes were established and characterized...
October 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28731147/beclin-1-overexpression-inhibits-chondrocyte-apoptosis-and-downregulates-extracellular-matrix-metabolism-in-osteoarthritis
#13
Bin Song, Hong Song, Weiguo Wang, Hongru Wang, Hanyuan Peng, Jing Cui, Rong Wang, Hua Huang, Wei Wang, Lili Wang
In the present study, the expression of Beclin 1 in osteoarthritis (OA) cartilage tissue was investigated, and also its role in proliferation, apoptosis and expression of matrix metalloproteinases (MMPs) in chondrocytes obtained from patients with OA. Beclin 1 expression in cartilage tissue from OA patients, and in the age- and sex-matched controls, was detected by immunohistochemistry, semi-quantitative polymerase chain reaction and western blotting. Chondrocytes were divided into control and Beclin 1-overexpressed groups...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28731145/piezo1-protein-induces-the-apoptosis-of-human-osteoarthritis-derived-chondrocytes-by-activating-caspase-12-the-signaling-marker-of-er-stress
#14
Xiao-Fei Li, Zhao Zhang, Zhu-Ke Chen, Zhao-Wei Cui, Hai-Ning Zhang
The present study was carried out to determine whether the mechanically activated cation channel Piezo1 protein plays a role as a signaling pathway which causes the apoptosis of human chondrocytes. The chondrocytes were isolated, cultured, and then subjected to mechanical stretch force for 0, 2, 12, 24 and 48 h, respectively. The expression levels of Piezo1 and the apoptosis-related protein caspase-12 were assessed by reverse transcription-quantitative polymerase chain reaction, as well as the apoptosis-related genes, B cell lymphoma/leukemia-2 (Bcl-2), Bcl-associated X protein (Bax) and Bcl-2-associated death promoter (BAD)...
July 19, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28730727/better-arthritis-care-patients-expectations-and-priorities-the-competencies-that-community-based-health-professionals-need-to-improve-their-care-of-people-with-arthritis
#15
J Erwin, K Edwards, A Woolf, S Whitcombe, S Kilty
OBJECTIVE: The aim of the present study was to identify the competencies that patients think non-specialist community-based nurses and allied health professionals (AHPs) need to enable them to assess, care for and manage arthritis appropriately. METHODS: Four face-to-face focus groups were held with a total of 16 women and nine men with arthritis, to discuss the care they received from community-based health professionals, the skills and knowledge they expected from community-based health professionals and what they prioritized...
July 21, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28730231/chondroprotective-effects-of-pulsed-shortwave-therapy-in-rabbits-with-experimental-osteoarthritis
#16
Rodica Ana Ungur, Adrian Florea, Alexandru Flaviu Tăbăran, Iuliu Călin Scurtu, Ioan Onac, Ileana Monica Borda, László Irsay, Viorela Mihaela Ciortea, Eleonora Dronca, Mihnea Tudor Zdrenghea, ŞoimiŢa Mihaela Suciu
INTRODUCTION: Osteoarthritis (OA) represents a public health challenge since the pathogenic treatment, able to induce cartilage regeneration, still remains unknown. Ageing of the population and increasing OA prevalence have led to a lot of research, aiming to identify treatments acting on chondrocytes that play a determinant role in cartilage degeneration÷regeneration balance. Pulsed shortwave therapy (with the classical application form - Diapulse) is a physiotherapy method with anabolic effects demonstrated on nervous, conjunctive and vascular tissues, but its effects on OA cartilage are not known...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729949/modeling-the-effect-of-blunt-impact-on-mitochondrial-function-in-cartilage-implications-for-development-of-osteoarthritis
#17
Georgi I Kapitanov, Bruce P Ayati, James A Martin
OBJECTIVE: Osteoarthritis (OA) is a disease characterized by degeneration of joint cartilage. It is associated with pain and disability and is the result of either age and activity related joint wear or an injury. Non-invasive treatment options are scarce and prevention and early intervention methods are practically non-existent. The modeling effort presented in this article is constructed based on an emerging biological hypothesis-post-impact oxidative stress leads to cartilage cell apoptosis and hence the degeneration observed with the disease...
2017: PeerJ
https://www.readbyqxmd.com/read/28728848/endoplasmic-reticulum-stress-participates-in-the-progress-of-senescence-and-apoptosis-of-osteoarthritis-chondrocytes
#18
Yake Liu, Hai Zhu, Xin Yan, Haoye Gu, Zhifeng Gu, Fan Liu
Endoplasmic reticulum stress (ERS) has been shown to participate in many disease pathologies. Recent reports have reported that ERS exists in human osteoarthritis (OA) chondrocytes. During OA, chondrocytes exhibit increased level of some senescence marker, such as senescence-associated β-galactosidase (SA β-gal) activity. However, the persistence and accumulation of senescent cells in various tissues can also impair function and have been involved in the pathogenesis of many age-related diseases, including OA...
July 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28728606/levels-of-serum-biomarkers-from-a-two-year-multicentre-trial-are-associated-with-treatment-response-on-knee-osteoarthritis-cartilage-loss-as-assessed-by-magnetic-resonance-imaging-an-exploratory-study
#19
Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme, Jean-Pierre Pelletier
BACKGROUND: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with knee OA, the likelihood of some serum biomarkers to be associated with a better response to chondroitin sulfate in reducing cartilage volume loss. METHODS: Eight biomarkers were studied: hyaluronic acid (HA), C reactive protein (CRP), adipsin, leptin, N-terminal propeptide of collagen IIα (PIIANP), C-terminal crosslinked telopeptide of type I collagen (CTX-1), matrix metalloproteinase-1 (MMP-1), and MMP-3...
July 20, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28728444/determinants-of-pain-disability-health-related-quality-of-life-and-physical-performance-in-patients-with-knee-osteoarthritis-awaiting-total-joint-arthroplasty
#20
Véronique Lowry, Philippe Ouellet, Pascal-André Vendittoli, Lisa C Carlesso, Timothy H Wideman, François Desmeules
PURPOSE: In patients suffering from knee osteoarthritis awaiting knee arthroplasty, to measure associations between several selected determinants and pain, disability, health-related quality of life and physical performance. MATERIAL AND METHODS: Validated self-reported measures were collected: (1) Western Ontario and McMaster Universities Osteoarthritis Index, (2) Lower Extremity Functional Scale (LEFS) and (3) Short-Form 36 (SF-36). Physical performance was also assessed with four validated performance tests...
July 20, 2017: Disability and Rehabilitation
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