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Very Low Calorie Diet (VLCD )

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https://www.readbyqxmd.com/read/27898428/beneficial-effects-of-a-dietary-weight-loss-intervention-on-human-gut-microbiome-diversity-and-metabolism-are-not-sustained-during-weight-maintenance
#1
Femke-Anouska Heinsen, Daniela Fangmann, Nike Müller, Dominik M Schulte, Malte C Rühlemann, Kathrin Türk, Ute Settgast, Wolfgang Lieb, John F Baines, Stefan Schreiber, Andre Franke, Matthias Laudes
OBJECTIVE: In the present study, we examined the effect of a very low-calorie diet(VLCD)-based obesity program on human gut microbiome diversity and metabolism during weight loss and weight maintenance. METHODS: Obese subjects underwent 3 months of VLCD followed by 3 months of weight maintenance. A lean and an obese control group were included. The microbiome was characterized by performing high-throughput dual-indexed 16S rDNA amplicon sequencing. RESULTS: At baseline, a significant difference in the Firmicutes/Bacteroidetes ratio between the lean and obese individuals was observed (p = 0...
November 30, 2016: Obesity Facts
https://www.readbyqxmd.com/read/27812384/sweet-taste-preferences-before-and-after-an-intensive-medical-weight-loss-intervention
#2
K Asao, A E Rothberg, L Arcori, M Kaur, C E Fowler, W H Herman
OBJECTIVE: Medical weight loss could change sweet taste threshold and preferences. The decrease in sweet taste preferences may, in turn, help in the maintenance of weight loss. This study examined the association between sweet taste preferences at baseline and weight change during a medical weight management programme and the impact of diet-induced weight loss on sweet taste preferences. METHODS: Adult patients with body mass index ≥32 kg m(-2) were recruited from a medical weight management clinic...
June 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27773549/effects-of-acute-dietary-weight-loss-on-postprandial-plasma-bile-acid-responses-in-obese-insulin-resistant-subjects
#3
F Samuel van Nierop, W Kulik, Erik Endert, Frank G Schaap, Steven W Olde Damink, Johannes A Romijn, Maarten R Soeters
BACKGROUND & AIMS: Bile acids (BA) are pleiotropic hormones affecting glucose and lipid metabolism. The physiochemical properties of different BA species affect their enterohepatic dynamics and their affinity for bile acid receptors. The BA pool composition is altered in patients with type 2 diabetes and obesity. In this study we used a 2-week very-low-calorie diet (VLCD) to investigate the effects of weight loss on BA pool composition and postprandial dynamics. METHODS: We performed mixed meal tests in obese, insulin resistant subjects before and after the VLCD...
October 13, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27733249/weight-loss-induced-by-very-low-calorie-diet-is-associated-with-a-more-beneficial-systemic-inflammatory-profile-than-by-roux-en-y-gastric-bypass
#4
Mirjam A Lips, Jan Bert van Klinken, Hanno Pijl, Ignace Janssen, Ko Willems van Dijk, Frits Koning, Vanessa van Harmelen
INTRODUCTION: Weight loss interventions such as Roux-en-Y gastric bypass (RYGB) and very low calorie diets (VLCD) lead to improvement of glucose metabolism in obese individuals with type-2 diabetes. Weight loss can also positively influence the unfavorable inflammatory profile associated with obesity. However, a direct comparison of the effect of VLCD and RYGB on systemic inflammation is lacking. METHODS: Systemic inflammation was investigated in age- and BMI-matched morbidly obese T2DM women by determining the number and activation- or memory status of peripheral blood leukocytes by flow cytometry, in addition to measuring circulating levels of cytokines and CRP...
November 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27715401/comparison-of-early-2-days-and-later-28-days-response-of-adipose-tissue-to-very-low-calorie-diet-in-obese-women
#5
Veronika Šrámková, Lenka Rossmeislová, Eva Krauzová, Jana Kračmerová, Michal Koc, Dominique Langin, Vladimír Štich, Michaela Šiklová
CONTEXT: Beneficial metabolic effects of calorie restriction found in the early stage of hypocalorie diets may be caused by the modulation of metabolic and endocrine function of adipose tissue. OBJECTIVE: To compare metabolic and inflammation-related characteristics of subcutaneous adipose tissue (SAAT) in the early (2 days) and later (28 days) phase of VLCD. Design, Setting, Intervention and Patients: 17 moderately obese premenopausal women followed 800 kcal/d VLCD for 28 days...
October 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27708846/alternate-day-versus-daily-energy-restriction-diets-which-is-more-effective-for-weight-loss-a-systematic-review-and-meta-analysis
#6
REVIEW
B A Alhamdan, A Garcia-Alvarez, A H Alzahrnai, J Karanxha, D R Stretchberry, K J Contrera, A F Utria, L J Cheskin
BACKGROUND: Alternate-day-fasting (ADF) has been proposed as an effective dieting method. Studies have found that it also can increase life span in rodents, and reduce inflammation in humans. The aim of this paper was to systematically review the efficacy of ADF compared to very-low-calorie dieting (VLCD) in terms of weight loss, and reduction of fat mass and fat-free mass. METHODS: Systematic review: PubMed literature searches were performed. Fixed review procedures were applied...
September 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/27698345/weight-losses-with-low-energy-formula-diets-in-obese-patients-with-and-without-type-2-diabetes-systematic-review-and-meta-analysis
#7
REVIEW
W S Leslie, R Taylor, L Harris, M E J Lean
AIM: To provide a systematic review, of published data, to compare weight losses following Very Low Calorie (<800 kcal/day VLCD) or Low Energy Liquid-formula (>800 kcal/day LELD) diets, in people with and without T2DM (T2DM). METHODS: Medline Systematic electronic searches of Medline (1946-2015) and Embase (1947-2015) to identify published studies using formula Total Diet Replacement diets (VLCD/LELD). Random effects meta-analysis using Weighted Mean Difference (WMD) in body weight between groups (with and without diabetes) as the summary estimate...
October 4, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27530911/acute-changes-in-non-esterified-fatty-acids-in-patients-with-type-2-diabetes-receiving-bariatric-surgery
#8
Reza Nemati, Jun Lu, Andrea Tura, Greg Smith, Rinki Murphy
BACKGROUND: The purpose of this study was to compare acute changes of non-esterified fatty acids (NEFA) in relation to beta cell function (BCF) and insulin resistance in obese patients with type 2 diabetes (T2D) who underwent laparoscopic gastric bypass (GBP), laparoscopic sleeve gastrectomy (SG) or very low calorie diet (VLCD). METHODS: In a non-randomised study, fasting plasma samples were collected from 38 obese patients with T2D, matched for age, body mass index (BMI) and glycaemic control, who underwent GBP (11) or SG (14) or VLCD (13)...
August 16, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27387696/improved-glucose-metabolism-after-gastric-bypass-evolution-of-the-paradigm
#9
Dimitri J Pournaras, Jonas Nygren, Eva Hagström-Toft, Peter Arner, Carel W le Roux, Anders Thorell
BACKGROUND: Glucose metabolism is improved in patients with type 2 diabetes after Roux-en-Y gastric bypass (RYGB). OBJECTIVES: To quantify the relative contribution of calorie restriction, rerouting of nutrients, and adipose tissue reduction. SETTING: University Hospital. METHODS: Fifteen diabetic patients, (47±9 yr, body mass index 41.3±4.2 kg/m(2)) were randomized to a 2-week very low-calorie diet (VLCD) regimen or normal diet before RYGB...
March 23, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27383313/very-low-calorie-ketogenic-diet-with-aminoacid-supplement-versus-very-low-restricted-calorie-diet-for-preserving-muscle-mass-during-weight-loss-a-pilot-double-blind-study
#10
G Merra, R Miranda, S Barrucco, P Gualtieri, M Mazza, E Moriconi, M Marchetti, T F M Chang, A De Lorenzo, L Di Renzo
OBJECTIVE: Obesity plays a relevant pathophysiological role in the development of health problems, arising as result of complex interaction of genetic, nutritional and metabolic factors. We conducted a dietary intervention case-control randomized trial, to compare the effectiveness on body composition of two nutritional protocols: a very-low-carbohydrate ketogenic diet (VLCKD), integrated by an aminoacid supplement with whey protein, and very low restricted-calorie diet (VLCD). PATIENTS AND METHODS: The clinical study was conducted with a randomized case-control in which twenty-five healthy subjects gave informed consent to participate in the interventional study and were evaluated for their health and nutritional status, by anthropometric, and body composition evaluation...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27312699/energy-restriction-and-roux-en-y-gastric-bypass-reduce-postprandial-%C3%AE-dicarbonyl-stress-in-obese-women-with-type-2-diabetes
#11
Dionne E Maessen, Nordin M Hanssen, Mirjam A Lips, Jean L Scheijen, Ko Willems van Dijk, Hanno Pijl, Coen D Stehouwer, Casper G Schalkwijk
AIMS/HYPOTHESIS: Dicarbonyl compounds are formed as byproducts of glycolysis and are key mediators of diabetic complications. However, evidence of postprandial α-dicarbonyl formation in humans is lacking, and interventions to reduce α-dicarbonyls have not yet been investigated. Therefore, we investigated postprandial α-dicarbonyl levels in obese women without and with type 2 diabetes. Furthermore, we evaluated whether a diet very low in energy (very low calorie diet [VLCD]) or Roux-en-Y gastric bypass (RYGB) reduces α-dicarbonyl stress in obese women with type 2 diabetes...
September 2016: Diabetologia
https://www.readbyqxmd.com/read/27282870/microdialysis-and-proteomics-of-subcutaneous-interstitial-fluid-reveals-increased-galectin-1-in-type-2-diabetes-patients
#12
Emanuel Fryk, Jeanna Perman Sundelin, Lena Strindberg, Maria J Pereira, Massimo Federici, Nikolaus Marx, Fredrik H Nyström, Martin Schmelz, Per-Arne Svensson, Jan W Eriksson, Jan Borén, Per-Anders Jansson
OBJECTIVE: To identify a potential therapeutic target for type 2 diabetes by comparing the subcutaneous interstitial fluid from type 2 diabetes patients and healthy men. METHODS: Proteomics was performed on the interstitial fluid of subcutaneous adipose tissue obtained by microdialysis from 7 type 2 diabetes patients and 8 healthy participants. 851 proteins were detected, of which 36 (including galectin-1) showed significantly altered expression in type 2 diabetes...
July 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27258913/preoperative-very-low-calorie-diet-reduces-technical-difficulty-during-laparoscopic-cholecystectomy-in-obese-patients
#13
Alexander D Jones, Peter W Waterland, Sarah Powell-Brett, Paul Super, Martin Richardson, Douglas Bowley
This study investigates the effectiveness of preoperative very low-calorie diet (VLCD) in laparoscopic cholecystectomy. A prospective observational study of consecutive patients undergoing laparoscopic cholecystectomy was undertaken. At the preoperative visit, all patients were advised to adhere to VLCD for 2 weeks before surgery (<800 kcal/d). Patients were judged to have complied with the VLCD if weight loss >2 kg. Technical difficulty was assessed using questionnaires. A total of 38 patients met the inclusion criteria...
June 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27154810/a-randomised-single-blinded-trial-assessing-the-effect-of-a-two-week-preoperative-very-low-calorie-diet-on-laparoscopic-cholecystectomy-in-obese-patients
#14
Katherine M Burnand, Rajiv P Lahiri, Nicholas Burr, Lize Jansen van Rensburg, Michael P N Lewis
BACKGROUND: Laparoscopic cholecystectomy (LC) can be technically challenging in the obese. The primary aim of the trial was to establish whether following a Very Low Calorie Diet (VLCD) for two weeks pre-operatively reduces operation time. Secondary outcomes included perceived operative difficulty and length of hospital stay. METHODS: A single-blinded, randomized controlled trial of consecutive patients with symptomatic gallstones and BMI >30 kg/m(2) 46 patients were randomized to a VLCD or normal diet for two weeks prior to LC...
May 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27135654/angiopoietin-like-protein-6-in-patients-with-obesity-type-2-diabetes-mellitus-and-anorexia-nervosa-the-influence-of-very-low-calorie-diet-bariatric-surgery-and-partial-realimentation
#15
Anna Cinkajzlova, Zdenka Lacinova, Jana Klouckova, Petra Kavalkova, Pavel Trachta, Mikulas Kosak, Denisa Haluzikova, Hana Papezova, Milos Mraz, Martin Haluzík
AIM OF THE STUDY: Angiopoietin-like protein 6 (ANGPTL6) is a circulating protein with a potential role in energy homeostasis. The aim of the study was to explore the changes in ANGPTL6 levels in patients with obesity (Body mass index, BMI > 40 kg/m(2)) with and without type 2 diabetes mellitus (T2DM) undergoing dietary intervention (very low calorie diet - VLCD) and in a subgroup of T2DM patients after bariatric surgery. Additionally, we examined changes in ANGPTL6 in anorexia nervosa (AN) patients at baseline and after partial realimentation...
May 2, 2016: Endocrine Research
https://www.readbyqxmd.com/read/27070750/plasma-concentrations-and-subcutaneous-adipose-tissue-mrna-expression-of-clusterin-in-obesity-and-type-2-diabetes-mellitus-the-effect-of-short-term-hyperinsulinemia-very-low-calorie-diet-and-bariatric-surgery
#16
J Kloučková, Z Lacinová, P Kaválková, P Trachta, M Kasalický, D Haluzíková, M Mráz, M Haluzík
Clusterin is a heterodimeric glycoprotein with wide range of functions. To further explore its possible regulatory role in energy homeostasis and in adipose tissue, we measured plasma clusterin and its mRNA expression in subcutaneous adipose tissue (SCAT) of 15 healthy lean women, 15 obese women (OB) and 15 obese women with type 2 diabetes mellitus (T2DM) who underwent a 2-week very low-calorie diet (VLCD), 10 obese women without T2DM who underwent laparoscopic sleeve gastrectomy (LSG) and 8 patients with T2DM, 8 patients with impaired glucose tolerance (IGT) and 8 normoglycemic patients who underwent hyperinsulinemic euglycemic clamp (HEC)...
July 18, 2016: Physiological Research
https://www.readbyqxmd.com/read/27002059/very-low-calorie-diet-and-6-months-of-weight-stability-in-type-2-diabetes-pathophysiological-changes-in-responders-and-nonresponders
#17
Sarah Steven, Kieren G Hollingsworth, Ahmad Al-Mrabeh, Leah Avery, Benjamin Aribisala, Muriel Caslake, Roy Taylor
OBJECTIVE: Type 2 diabetes mellitus (T2DM) is generally regarded as an irreversible chronic condition. Because a very low-calorie diet (VLCD) can bring about acute return to normal glucose control in some people with T2DM, this study tested the potential durability of this normalization. The underlying mechanisms were defined. RESEARCH DESIGN AND METHODS: People with a T2DM duration of 0.5-23 years (n = 30) followed a VLCD for 8 weeks. All oral agents or insulins were stopped at baseline...
May 2016: Diabetes Care
https://www.readbyqxmd.com/read/26813524/the-effect-of-rate-of-weight-loss-on-long-term-weight-regain-in-adults-with-overweight-and-obesity
#18
RANDOMIZED CONTROLLED TRIAL
Roel G Vink, Nadia J T Roumans, Laura A J Arkenbosch, Edwin C M Mariman, Marleen A van Baak
OBJECTIVE: To investigate the effect of rate of weight loss, with similar total weight loss, on weight regain in individuals with overweight and obesity. METHODS: Fifty-seven participants (BMI: 28-35 kg/m(2) ) underwent a dietary intervention (DI). They were randomized to a low-calorie diet (LCD; 1250 kcal/day) for 12 weeks (slow weight loss) or a very-low-calorie diet (VLCD; 500 kcal/day) for 5 weeks (rapid weight loss) (weight loss (WL) period) followed by a 4-week weight-stable (WS) period and 9 months follow-up...
February 2016: Obesity
https://www.readbyqxmd.com/read/26670679/comparison-of-preoperative-diets-before-bariatric-surgery-a-randomized-single-blinded-non-inferiority-trial
#19
Ruben Schouten, Inge van der Kaaden, Gerhard van 't Hof, Pierre G B M Feskens
OBJECTIVE: In order to increase weight loss and minimize complications, a preoperative diet before bariatric has been advocated. However, some diets are poorly tolerated by patients and this can lead to low compliance and too little weight loss. In this study, we aim to compare two preoperative diets in order to find the most suitable for this patient population. METHODS: Comparison of preoperative diets before bariatric surgery with a randomized non-inferiority trial in order to compare the standard very low calorie diet (VLCD) by protein shakes (Prodimed) with a standard diet using ordinary products...
August 2016: Obesity Surgery
https://www.readbyqxmd.com/read/26586092/systematic-review-and-meta-analysis-reveals-acutely-elevated-plasma-cortisol-following-fasting-but-not-less-severe-calorie-restriction
#20
Yuko Nakamura, Brian R Walker, Toshikazu Ikuta
Elevated plasma cortisol has been reported following caloric restriction, and may contribute to adverse effects including stress-induced overeating, but results from published studies are inconsistent. To clarify the effects of caloric restriction on plasma cortisol, and to assess cortisol as an indicator of stress during caloric restriction, we conducted a systematic review and meta-analysis of published studies in which cortisol was measured following caloric restriction without other manipulations in humans...
2016: Stress: the International Journal on the Biology of Stress
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