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wearing off Parkinsonism

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https://www.readbyqxmd.com/read/29776864/putaminal-dopamine-depletion-in-de-novo-parkinson-s-disease-predicts-future-development-of-wearing-off
#1
Su Jin Chung, Yoonju Lee, Jungsu S Oh, Jae Seung Kim, Phil Hyu Lee, Young H Sohn
INTRODUCTION: The present study aimed to investigate whether the level of presynaptic dopamine neuronal loss predicts future development of wearing-off in de novo Parkinson's disease. METHODS: This retrospective cohort study included a total of 342 non-demented patients with de novo Parkinson's disease who underwent dopamine transporter positron emission tomography scans at their initial evaluation and received dopaminergic medications for 24 months or longer. Onset of wearing-off was determined based on patients' medical records at their outpatient clinic visits every 3-6 months...
May 10, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29748109/efficacy-and-safety-of-adjunctive-rasagiline-in-japanese-parkinson-s-disease-patients-with-wearing-off-phenomena-a-phase-2-3-randomized-double-blind-placebo-controlled-multicenter-study
#2
Nobutaka Hattori, Atsushi Takeda, Shinichi Takeda, Akira Nishimura, Masafumi Kato, Hideki Mochizuki, Masahiro Nagai, Ryosuke Takahashi
INTRODUCTION: Rasagiline, a selective, irreversible monoamine oxidase-B inhibitor, is in development in Japan as adjunctive therapy to levodopa. This Phase 2/3 trial evaluated the efficacy and safety of adjunctive rasagiline in Japanese patients with Parkinson's disease (PD) and wearing-off phenomena. METHODS: Patients aged 30-79 years with diagnosed PD and stable levodopa use were randomized 1:1:1 to rasagiline (0.5/1 mg/day) or placebo for 26 weeks. The primary endpoint was change from baseline in mean daily OFF-time during the treatment period...
April 27, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29700848/non-pharmacological-therapies-for-sleep-disturbances-in-people-with-parkinson-s-disease-a-systematic-review
#3
REVIEW
JuHee Lee, Yonji Kim, YieLin Kim
AIM: To determine the effectiveness of non-pharmacological therapies for sleep disturbances in people with Parkinson's disease. BACKGROUND: Sleep disturbances, which are common in people with Parkinson's disease, may diminish their quality of life. Non-pharmacological therapies are preferred over pharmacological therapies for improving sleep quality, owing to fewer adverse effects. DESIGN: Systematic literature review. DATA SOURCES: A systematic search of eight databases and hand searching was conducted for papers published between 1 January 1 2000 - 1 January 2016...
April 27, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29695377/a-kinematic-sensor-and-algorithm-to-detect-motor-fluctuations-in-parkinson-disease-validation-study-under-real-conditions-of-use
#4
Alejandro Rodríguez-Molinero, Carlos Pérez-López, Albert Samà, Eva de Mingo, Daniel Rodríguez-Martín, Jorge Hernández-Vara, Àngels Bayés, Alfons Moral, Ramiro Álvarez, David A Pérez-Martínez, Andreu Català
BACKGROUND: A new algorithm has been developed, which combines information on gait bradykinesia and dyskinesia provided by a single kinematic sensor located on the waist of Parkinson disease (PD) patients to detect motor fluctuations (On- and Off-periods). OBJECTIVE: The goal of this study was to analyze the accuracy of this algorithm under real conditions of use. METHODS: This validation study of a motor-fluctuation detection algorithm was conducted on a sample of 23 patients with advanced PD...
April 25, 2018: JMIR Rehabilitation and Assistive Technologies
https://www.readbyqxmd.com/read/29672326/long-term-outcome-of-adenosine-a2a-receptor-antagonist-on-lower-urinary-tract-symptoms-in-male-parkinson-disease-patients
#5
Takeya Kitta, Ichiro Yabe, Yukiko Kanno, Madoka Higuchi, Mifuka Ouchi, Mio Togo, Kimihiko Moriya, Ikuko Takahashi, Masaaki Matsushima, Hidenao Sasaki, Nobuo Shinohara
OBJECTIVES: In addition to motor symptoms, bladder dysfunction is a major clinical issue in patients with Parkinson disease (PD). Istradefylline is adenosine A2A receptor antagonist approved for PD patients with wearing-off symptoms. The aim of this study was to determine the long-term effects of istradefylline on lower urinary tract symptoms (LUTSs) in PD patients. METHODS: We enrolled 14 male PD patients. The mean age of patients was 73 years (61-77 years), the Hoehn-Yahr stage was 2 (2-3), and disease duration was 9 years (3-28 years)...
April 18, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29662465/the-length-of-snca-rep1-microsatellite-may-influence-cognitive-evolution-in-parkinson-s-disease
#6
Lucia Corrado, Fabiola De Marchi, Sara Tunesi, Gaia Donata Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D'Alfonso, Corrado Magnani, Giacomo P Comi, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano Goldwurm, Cristoforo Comi
Background: Alpha-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial Parkinson's disease (PD). A previous study showed that a variant of the alpha-synuclein gene ( SNCA ), namely the 263 bp allele of Rep1 was associated with faster motor progression in PD. On the contrary, a recent report failed to detect a detrimental effect of Rep1 263 on both motor and cognitive outcomes in PD. Aim of this study was to evaluate the influence of the Rep1 variants on disease progression in PD patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29652438/individualization-of-levodopa-treatment-using-a-microtablet-dispenser-and-ambulatory-accelerometry
#7
Dongni Johansson, Anders Ericsson, Anders Johansson, Alexander Medvedev, Dag Nyholm, Fredrik Ohlsson, Marina Senek, Jack Spira, Ilias Thomas, Jerker Westin, Filip Bergquist
AIM: This 4-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring in individuals with Parkinson's disease (PD). METHODS: Twenty-eight outpatients with PD on stable levodopa treatment with dose intervals of ≤4 hour had their daytime doses of levodopa replaced with levodopa/carbidopa microtablets, 5/1.25 mg (LC-5) delivered from a dose dispenser device with programmable reminders...
May 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29572255/cardiac-sympathetic-denervation-can-predict-the-wearing-off-phenomenon-in-patients-with-parkinson-s-disease
#8
Jee-Eun Lee, Joong-Seok Kim, Dong-Woo Ryu, Yoon-Sang Oh, Ie Ryung Yoo, Kwang-Soo Lee
Recent studies have suggested that preserved cardiac sympathetic denervation may be associated with a small motor burden in Parkinson's disease (PD), and serve as a "good" marker which is not associated with other non-motor symptoms. We sought to investigate whether cardiac sympathetic denervation increases the risk of the early wearing-off phenomenon in PD. Methods: This hospital-based prospective study enrolled 266 de novo patients with PD who underwent123 I-metaiodobenzylguanidine (MIBG) scintigraphy on initial evaluation...
March 23, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29569037/monoamine-oxidase-b-inhibitors-in-the-treatment-of-parkinson-s-disease-clinical-pharmacological-aspects
#9
REVIEW
Peter Riederer, Thomas Müller
This invited narrative review emphasizes the role of MAO-B inhibition in the drug portfolio for dopamine substitution in patients with Parkinson's disease. Neuronal and glial MAO-B inhibition contributes to more stable levels of dopamine and other biogenic amines in the synaptic cleft. Accordingly, symptomatic effects of MAO-B inhibition for a limited amelioration of impaired motor behaviour and wearing-off phenomena in patients with Parkinson's disease are well proven, even when MAO-B inhibitors are only applied together with dopamine agonists...
March 22, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29526790/selegiline-increases-on-time-without-exacerbation-of-dyskinesia-in-6-hydroxydopamine-lesioned-rats-displaying-l-dopa-induced-wearing-off-and-abnormal-involuntary-movements
#10
Hiroko Tsunekawa, Kazue Takahata, Motoki Okano, Toshiko Ishikawa, Hiroshi Satoyoshi, Tetsuya Nishimura, Naoya Hoshino, Shizuko Muraoka
3,4-Dihydroxy-l-phenylalanine (l-Dopa) remains the most effective drug for treating the motor symptoms of Parkinson's disease (PD). However, its long-term use is limited due to motor complications such as wearing-off and dyskinesia. A clinical study in PD patients with motor complications has demonstrated that selegiline, a monoamine oxidase type B inhibitor, is effective in reducing off time without worsening dyskinesia, although another study has shown worsening dyskinesia. Here, using unilateral 6-hydroxydopamine-lesioned rats showing degeneration of nigrostriatal dopaminergic neurons and l-Dopa-induced motor complications, we determined the efficacy of selegiline in controlling l-Dopa-induced motor fluctuations and exacerbated dyskinesia...
March 8, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29521236/in-silico-studies-targeting-g-protein-coupled-receptors-for-drug-research-against-parkinson-s-disease
#11
Agostinho Lemos, Rita Meloc, Antonio J Preto, Jose G Almeida, Irina S Moreira, M Natalia D S Cordeiro
Parkinson's Disease (PD) is a long-term neurodegenative brain disorder that mainly affects the motor system. The causes are still unknown, and even though currently there is no cure, several therapeutic options are available to manage its symptoms. The development of novel anti-parkinsonian agents and an understanding of their proper and optimal use are, indeed, highly demanding. For the last decades, L-3,4-DihydrOxyPhenylAlanine or levodopa (L-DOPA) has been the gold-standard therapy for the symptomatic treatment of motor dysfunctions associated to PD...
March 8, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29511383/safety-and-efficacy-of-levodopa-carbidopa-intestinal-gel-results-from-an-open-label-extension-study-in-japanese-korean-and-taiwanese-patients-with-advanced-parkinson-s-disease
#12
Miho Murata, Masahito Mihara, Kazuko Hasegawa, Beomseok Jeon, Chon-Haw Tsai, Noriko Nishikawa, Tomoko Oeda, Masayuki Yokoyama, Weining Z Robieson, Krai Chatamra, Maurizio F Facheris, Janet Benesh
Objectives: Levodopa-carbidopa intestinal gel (LCIG) was developed to reduce motor complications in Parkinson's disease (PD) caused by pulsatile levodopa plasma concentrations following oral levodopa administration. Dyskinesia and 'wearing off' symptoms can vary between Asian and Caucasian patients with PD, thus highlighting the importance of assessing the effectiveness of LCIG in an Asian population. Efficacy and safety of LCIG were previously assessed in a 12-week open-label study; we report the efficacy and safety of at least 52 weeks of LCIG treatment in Japanese, Taiwanese, and Korean patients with advanced PD in the ongoing extension study...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29488257/animal-models-of-l-dopa-induced-dyskinesia-in-parkinson-s-disease
#13
REVIEW
M Angela Cenci, Alan R Crossman
Understanding the biological mechanisms of l-dopa-induced motor complications is dependent on our ability to investigate these phenomena in animal models of Parkinson's disease. The most common motor complications consist in wearing-off fluctuations and abnormal involuntary movements appearing when plasma levels of l-dopa are high, commonly referred to as peak-dose l-dopa-induced dyskinesia. Parkinsonian models exhibiting these features have been well-characterized in both rodent and nonhuman primate species...
February 28, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29434569/cranio-caudal-kinematic-turn-signature-assessed-with-inertial-systems-as-a-marker-of-mobility-deficits-in-parkinson-s-disease
#14
Karina Lebel, Christian Duval, Hung Phuc Nguyen, Réjean Plamondon, Patrick Boissy
Background: Turning is a challenging mobility task requiring proper planning, coordination, and postural stability to be executed efficiently. Turn deficits can impair mobility and lead to falls in patients with neurodegenerative disease, such as Parkinson's disease (PD). It was previously shown that the cranio-caudal sequence involved during a turn (i.e., motion is initiated by the head, followed by the trunk) exhibits a signature that can be captured using an inertial system and analyzed through the Kinematics Theory...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29167034/body-awareness-training-in-the-treatment-of-wearing-off-related-anxiety-in-patients-with-parkinson-s-disease-results-from-a-pilot-randomized-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Ires Ghielen, Erwin E H van Wegen, Sonja Rutten, Cees J T de Goede, Marieke Houniet-de Gier, Emma H Collette, Ingrid A L Burgers-Bots, Jos W R Twisk, Gert Kwakkel, Kees Vermunt, Bep van Vliet, Henk W Berendse, Odile A van den Heuvel
BACKGROUND: In Parkinson's disease (PD) patients, fluctuations in symptoms commonly occur after many years of dopamine replacement therapy. The so-called wearing-off phenomenon exists of both motor and non-motor symptoms, such as rigidity and anxiety. Current treatment options are limited and an integrated approach is needed to address the complex interactions between motor and non-motor symptoms. Since wearing-off is eventually inevitable, treatment needs to focus on coping, acceptance and self-efficacy...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29133700/wearing-off-a-complex-phenomenon-often-poorly-recognized-in-parkinson-s-disease-a-study-with-the-woq-19-questionnaire
#16
Michele Pistacchi, Manuela Gioulis, Flavio Sanson, Sandro Z Marsala
BACKGROUND: 'Wearing off' refers to the phenomenology of movement disorders in Parkinson's disease (PD) that appears early and is much commoner than generally believed. It may be present in the form of either motor symptoms or non-motor symptoms. AIM: To investigate the utility of wearing-off questionnaire (WOQ-19, Italian version) in the outpatient clinical practice to assess the suitability of different combinations of treatment, in various stages of PD. METHODS: 73 consecutive patients (58% male and 42% female) suffering from PD were recruited through the Santorso Hospital and San Martino Hospital from September 2012 to March 2014...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29100803/the-effects-of-cysteamine-in-a-mouse-model-of-levodopa-induced-dyskinesias
#17
Linda S David, Martine Saint-Pierre, Jérôme Lamontagne-Proulx, Francesca Cicchetti
Levo-dopa (L-DOPA) has shown significant and long-lasting efficacy in the treatment of motor features characteristic of Parkinson's disease (PD). However, the effects tend to wear off at a time typically when side-effects, such as L-DOPA induced dyskinesias (LIDs), start to emerge and for which the treatment options are very limited. In recent years, we have reported on the neuroprotective and neurorestorative properties of the compounds cystamine/cysteamine in ameliorating several aspects of PD. Building on these observations, we set out to further evaluate the benefits of cysteamine on LIDs...
October 31, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29079421/a-prospective-study-of-falls-in-relation-to-freezing-of-gait-and-response-fluctuations-in-parkinson-s-disease
#18
Yasuyuki Okuma, Ana Lígia Silva de Lima, Jiro Fukae, Bastiaan R Bloem, Anke H Snijders
INTRODUCTION: Falls are a disabling feature of Parkinson's disease (PD). In this prospective study we investigated: (1) in which motor state patients with PD fallmost often; and (2) whether freezing of gait (FOG) and dyskinesias contribute to falls. METHODS: Patients with PD who had fallen at least once in the previous year and had wearing-off were recruited. During six months, patients complete a standardized fall report. We analyzed data regarding fall circumstances and motor state at the time of each first 10 falls...
January 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29031781/the-effectiveness-of-istradefylline-for-the-treatment-of-gait-deficits-and-sleepiness-in-patients-with-parkinson-s-disease
#19
Keita Matsuura, Hiroyuki Kajikawa, Ken-Ichi Tabei, Masayuki Satoh, Hirotaka Kida, Naoko Nakamura, Hidekazu Tomimoto
PURPOSE: Istradefylline is useful in treating the wearing-off state in Parkinson's disease (PD). We investigated the effectiveness of istradefylline (ISD) in improving arousal, sleep, and gait deficits in patients with PD. METHODS: We examined 14 patients with PD treated with ISD. We assessed the patients using the Unified Parkinson's Disease Rating Scale, Parkinson's Disease Questionnaire, Timed Up-and-Go test (TUG), Freezing of Gait Questionnaire (FOG-Q), Epworth Sleepiness Scale (ESS), and Parkinson's Disease Sleep Scale (PDSS) before and 1 month after ISD use...
October 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29027941/verification-of-a-method-for-measuring-parkinson-s-disease-related-temporal-irregularity-in-spiral-drawings
#20
Somayeh Aghanavesi, Mevludin Memedi, Mark Dougherty, Dag Nyholm, Jerker Westin
Parkinson's disease (PD) is a progressive movement disorder caused by the death of dopamine-producing cells in the midbrain. There is a need for frequent symptom assessment, since the treatment needs to be individualized as the disease progresses. The aim of this paper was to verify and further investigate the clinimetric properties of an entropy-based method for measuring PD-related upper limb temporal irregularities during spiral drawing tasks. More specifically, properties of a temporal irregularity score (TIS) for patients at different stages of PD, and medication time points were investigated...
October 13, 2017: Sensors
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